-- dump date   	20140619_131338
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
573825000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
573825000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
573825000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825000004	Walker A motif; other site
573825000005	ATP binding site [chemical binding]; other site
573825000006	Walker B motif; other site
573825000007	arginine finger; other site
573825000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
573825000009	DnaA box-binding interface [nucleotide binding]; other site
573825000010	DNA polymerase III subunit beta; Provisional; Region: PRK14942
573825000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
573825000012	putative DNA binding surface [nucleotide binding]; other site
573825000013	dimer interface [polypeptide binding]; other site
573825000014	beta-clamp/clamp loader binding surface; other site
573825000015	beta-clamp/translesion DNA polymerase binding surface; other site
573825000016	recombination protein F; Reviewed; Region: recF; PRK00064
573825000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825000018	Walker A/P-loop; other site
573825000019	ATP binding site [chemical binding]; other site
573825000020	Q-loop/lid; other site
573825000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825000022	ABC transporter signature motif; other site
573825000023	Walker B; other site
573825000024	D-loop; other site
573825000025	H-loop/switch region; other site
573825000026	Protein of unknown function (DUF721); Region: DUF721; pfam05258
573825000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
573825000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825000029	Mg2+ binding site [ion binding]; other site
573825000030	G-X-G motif; other site
573825000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
573825000032	anchoring element; other site
573825000033	dimer interface [polypeptide binding]; other site
573825000034	ATP binding site [chemical binding]; other site
573825000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
573825000036	active site
573825000037	putative metal-binding site [ion binding]; other site
573825000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
573825000039	DNA gyrase subunit A; Validated; Region: PRK05560
573825000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
573825000041	CAP-like domain; other site
573825000042	active site
573825000043	primary dimer interface [polypeptide binding]; other site
573825000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
573825000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
573825000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
573825000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
573825000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
573825000049	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
573825000050	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
573825000051	FMN binding site [chemical binding]; other site
573825000052	active site
573825000053	catalytic residues [active]
573825000054	substrate binding site [chemical binding]; other site
573825000055	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
573825000056	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
573825000057	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
573825000058	active site
573825000059	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
573825000060	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
573825000061	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
573825000062	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
573825000063	Maf-like protein; Reviewed; Region: PRK00078
573825000064	active site
573825000065	dimer interface [polypeptide binding]; other site
573825000066	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
573825000067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825000068	NAD(P) binding site [chemical binding]; other site
573825000069	active site
573825000070	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
573825000071	Family description; Region: VCBS; pfam13517
573825000072	FG-GAP repeat; Region: FG-GAP; pfam01839
573825000073	Family description; Region: VCBS; pfam13517
573825000074	Family description; Region: VCBS; pfam13517
573825000075	Family description; Region: VCBS; pfam13517
573825000076	Family description; Region: VCBS; pfam13517
573825000077	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
573825000078	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
573825000079	putative ArsC-like catalytic residues; other site
573825000080	putative TRX-like catalytic residues [active]
573825000081	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
573825000082	FliG C-terminal domain; Region: FliG_C; pfam01706
573825000083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825000084	cyclase homology domain; Region: CHD; cd07302
573825000085	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825000086	nucleotidyl binding site; other site
573825000087	metal binding site [ion binding]; metal-binding site
573825000088	dimer interface [polypeptide binding]; other site
573825000089	hypothetical protein; Provisional; Region: PRK08444
573825000090	Protein of unknown function (DUF989); Region: DUF989; pfam06181
573825000091	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
573825000092	Cytochrome c; Region: Cytochrom_C; pfam00034
573825000093	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
573825000094	active site
573825000095	dimerization interface [polypeptide binding]; other site
573825000096	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
573825000097	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
573825000098	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
573825000099	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
573825000100	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
573825000101	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
573825000102	dimerization interface [polypeptide binding]; other site
573825000103	domain crossover interface; other site
573825000104	redox-dependent activation switch; other site
573825000105	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
573825000106	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
573825000107	Glycoprotease family; Region: Peptidase_M22; pfam00814
573825000108	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
573825000109	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825000110	RNB domain; Region: RNB; pfam00773
573825000111	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825000112	RNA binding site [nucleotide binding]; other site
573825000113	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
573825000114	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
573825000115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000116	binding surface
573825000117	TPR repeat; Region: TPR_11; pfam13414
573825000118	TPR motif; other site
573825000119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000120	binding surface
573825000121	TPR motif; other site
573825000122	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825000123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000124	binding surface
573825000125	TPR motif; other site
573825000126	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
573825000127	active site
573825000128	catalytic residue [active]
573825000129	dimer interface [polypeptide binding]; other site
573825000130	KpsF/GutQ family protein; Region: kpsF; TIGR00393
573825000131	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
573825000132	putative active site [active]
573825000133	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
573825000134	transcriptional activator RfaH; Region: RfaH; TIGR01955
573825000135	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
573825000136	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825000137	PAS domain; Region: PAS_9; pfam13426
573825000138	putative active site [active]
573825000139	heme pocket [chemical binding]; other site
573825000140	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825000141	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825000142	dimer interface [polypeptide binding]; other site
573825000143	putative CheW interface [polypeptide binding]; other site
573825000144	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
573825000145	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
573825000146	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
573825000147	NAD binding site [chemical binding]; other site
573825000148	putative substrate binding site 2 [chemical binding]; other site
573825000149	putative substrate binding site 1 [chemical binding]; other site
573825000150	active site
573825000151	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
573825000152	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
573825000153	ligand binding site [chemical binding]; other site
573825000154	homodimer interface [polypeptide binding]; other site
573825000155	NAD(P) binding site [chemical binding]; other site
573825000156	trimer interface B [polypeptide binding]; other site
573825000157	trimer interface A [polypeptide binding]; other site
573825000158	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
573825000159	active site
573825000160	histidyl-tRNA synthetase; Region: hisS; TIGR00442
573825000161	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
573825000162	dimer interface [polypeptide binding]; other site
573825000163	motif 1; other site
573825000164	active site
573825000165	motif 2; other site
573825000166	motif 3; other site
573825000167	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
573825000168	anticodon binding site; other site
573825000169	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
573825000170	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825000171	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825000172	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825000173	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825000174	ligand binding site [chemical binding]; other site
573825000175	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
573825000176	dihydropteroate synthase; Region: DHPS; TIGR01496
573825000177	substrate binding pocket [chemical binding]; other site
573825000178	dimer interface [polypeptide binding]; other site
573825000179	inhibitor binding site; inhibition site
573825000180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000181	binding surface
573825000182	TPR motif; other site
573825000183	TPR repeat; Region: TPR_11; pfam13414
573825000184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000185	binding surface
573825000186	TPR motif; other site
573825000187	TPR repeat; Region: TPR_11; pfam13414
573825000188	TPR repeat; Region: TPR_11; pfam13414
573825000189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000190	TPR motif; other site
573825000191	binding surface
573825000192	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
573825000193	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
573825000194	Sporulation related domain; Region: SPOR; pfam05036
573825000195	serine O-acetyltransferase; Region: cysE; TIGR01172
573825000196	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
573825000197	trimer interface [polypeptide binding]; other site
573825000198	active site
573825000199	substrate binding site [chemical binding]; other site
573825000200	CoA binding site [chemical binding]; other site
573825000201	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
573825000202	Peptidase family M50; Region: Peptidase_M50; pfam02163
573825000203	active site
573825000204	putative substrate binding region [chemical binding]; other site
573825000205	Uncharacterized conserved protein [Function unknown]; Region: COG3391
573825000206	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
573825000207	putative efflux protein, MATE family; Region: matE; TIGR00797
573825000208	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
573825000209	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
573825000210	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
573825000211	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825000212	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825000213	dimerization interface [polypeptide binding]; other site
573825000214	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825000215	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825000216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000217	binding surface
573825000218	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825000219	TPR motif; other site
573825000220	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
573825000221	Zn binding site [ion binding]; other site
573825000222	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
573825000223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825000224	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825000225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825000226	dimerization interface [polypeptide binding]; other site
573825000227	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825000228	TPR repeat; Region: TPR_11; pfam13414
573825000229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000230	binding surface
573825000231	TPR motif; other site
573825000232	TPR repeat; Region: TPR_11; pfam13414
573825000233	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
573825000234	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
573825000235	trimer interface [polypeptide binding]; other site
573825000236	active site
573825000237	enoyl-CoA hydratase; Provisional; Region: PRK07657
573825000238	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825000239	substrate binding site [chemical binding]; other site
573825000240	oxyanion hole (OAH) forming residues; other site
573825000241	trimer interface [polypeptide binding]; other site
573825000242	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
573825000243	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825000244	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
573825000245	active site
573825000246	metal binding site [ion binding]; metal-binding site
573825000247	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825000248	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
573825000249	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
573825000250	Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410
573825000251	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825000252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825000253	S-adenosylmethionine binding site [chemical binding]; other site
573825000254	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
573825000255	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
573825000256	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
573825000257	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
573825000258	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
573825000259	putative acyl-acceptor binding pocket; other site
573825000260	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825000261	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825000262	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825000263	Uncharacterized conserved protein [Function unknown]; Region: COG5439
573825000264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
573825000265	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
573825000266	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
573825000267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825000268	S-adenosylmethionine binding site [chemical binding]; other site
573825000269	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
573825000270	catalytic triad [active]
573825000271	HEAT repeats; Region: HEAT_2; pfam13646
573825000272	HEAT repeats; Region: HEAT_2; pfam13646
573825000273	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
573825000274	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
573825000275	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
573825000276	acyl-activating enzyme (AAE) consensus motif; other site
573825000277	CoA binding site [chemical binding]; other site
573825000278	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
573825000279	AMP binding site [chemical binding]; other site
573825000280	active site
573825000281	CoA binding site [chemical binding]; other site
573825000282	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
573825000283	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
573825000284	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
573825000285	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
573825000286	aminodeoxychorismate synthase; Provisional; Region: PRK07508
573825000287	chorismate binding enzyme; Region: Chorismate_bind; cl10555
573825000288	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
573825000289	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
573825000290	substrate-cofactor binding pocket; other site
573825000291	homodimer interface [polypeptide binding]; other site
573825000292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825000293	catalytic residue [active]
573825000294	MASE1; Region: MASE1; pfam05231
573825000295	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825000296	Histidine kinase; Region: HisKA_2; pfam07568
573825000297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825000298	ATP binding site [chemical binding]; other site
573825000299	Mg2+ binding site [ion binding]; other site
573825000300	G-X-G motif; other site
573825000301	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
573825000302	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
573825000303	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825000304	catalytic residue [active]
573825000305	peptide chain release factor 1; Validated; Region: prfA; PRK00591
573825000306	PCRF domain; Region: PCRF; pfam03462
573825000307	RF-1 domain; Region: RF-1; pfam00472
573825000308	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
573825000309	active site
573825000310	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
573825000311	nudix motif; other site
573825000312	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
573825000313	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
573825000314	putative active site pocket [active]
573825000315	4-fold oligomerization interface [polypeptide binding]; other site
573825000316	metal binding residues [ion binding]; metal-binding site
573825000317	3-fold/trimer interface [polypeptide binding]; other site
573825000318	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK14004
573825000319	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
573825000320	putative active site [active]
573825000321	oxyanion strand; other site
573825000322	catalytic triad [active]
573825000323	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
573825000324	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
573825000325	catalytic residues [active]
573825000326	Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920
573825000327	putative active site [active]
573825000328	redox center [active]
573825000329	Thioredoxin; Region: Thioredoxin_4; pfam13462
573825000330	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
573825000331	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
573825000332	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
573825000333	dimer interface [polypeptide binding]; other site
573825000334	substrate binding site [chemical binding]; other site
573825000335	ATP binding site [chemical binding]; other site
573825000336	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
573825000337	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
573825000338	DNA binding site [nucleotide binding]
573825000339	active site
573825000340	GAF domain; Region: GAF_3; pfam13492
573825000341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
573825000342	dimer interface [polypeptide binding]; other site
573825000343	phosphorylation site [posttranslational modification]
573825000344	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825000345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825000346	ATP binding site [chemical binding]; other site
573825000347	Mg2+ binding site [ion binding]; other site
573825000348	G-X-G motif; other site
573825000349	GTPase RsgA; Reviewed; Region: PRK00098
573825000350	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825000351	RNA binding site [nucleotide binding]; other site
573825000352	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
573825000353	GTPase/Zn-binding domain interface [polypeptide binding]; other site
573825000354	GTP/Mg2+ binding site [chemical binding]; other site
573825000355	G4 box; other site
573825000356	G5 box; other site
573825000357	G1 box; other site
573825000358	Switch I region; other site
573825000359	G2 box; other site
573825000360	G3 box; other site
573825000361	Switch II region; other site
573825000362	FecR protein; Region: FecR; pfam04773
573825000363	PEGA domain; Region: PEGA; pfam08308
573825000364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000365	binding surface
573825000366	TPR motif; other site
573825000367	TPR repeat; Region: TPR_11; pfam13414
573825000368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000369	binding surface
573825000370	TPR motif; other site
573825000371	TPR repeat; Region: TPR_11; pfam13414
573825000372	TPR repeat; Region: TPR_11; pfam13414
573825000373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000374	TPR motif; other site
573825000375	binding surface
573825000376	TPR repeat; Region: TPR_11; pfam13414
573825000377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000378	binding surface
573825000379	TPR motif; other site
573825000380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000381	binding surface
573825000382	TPR motif; other site
573825000383	TPR repeat; Region: TPR_11; pfam13414
573825000384	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
573825000385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000386	TPR motif; other site
573825000387	binding surface
573825000388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000389	binding surface
573825000390	TPR motif; other site
573825000391	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
573825000392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825000393	S-adenosylmethionine binding site [chemical binding]; other site
573825000394	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
573825000395	PilZ domain; Region: PilZ; pfam07238
573825000396	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
573825000397	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
573825000398	G1 box; other site
573825000399	GTP/Mg2+ binding site [chemical binding]; other site
573825000400	Switch I region; other site
573825000401	G2 box; other site
573825000402	G3 box; other site
573825000403	Switch II region; other site
573825000404	G4 box; other site
573825000405	G5 box; other site
573825000406	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
573825000407	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
573825000408	Ligand Binding Site [chemical binding]; other site
573825000409	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825000410	GAF domain; Region: GAF; pfam01590
573825000411	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
573825000412	GAF domain; Region: GAF; pfam01590
573825000413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825000414	Walker A motif; other site
573825000415	ATP binding site [chemical binding]; other site
573825000416	Walker B motif; other site
573825000417	arginine finger; other site
573825000418	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
573825000419	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
573825000420	SET domain; Region: SET; pfam00856
573825000421	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
573825000422	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
573825000423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825000424	Walker A/P-loop; other site
573825000425	ATP binding site [chemical binding]; other site
573825000426	Q-loop/lid; other site
573825000427	ABC transporter signature motif; other site
573825000428	Walker B; other site
573825000429	D-loop; other site
573825000430	H-loop/switch region; other site
573825000431	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
573825000432	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
573825000433	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
573825000434	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
573825000435	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
573825000436	Tetramer interface [polypeptide binding]; other site
573825000437	active site
573825000438	FMN-binding site [chemical binding]; other site
573825000439	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
573825000440	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
573825000441	catalytic loop [active]
573825000442	iron binding site [ion binding]; other site
573825000443	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
573825000444	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
573825000445	Molybdopterin oxidoreductase; Region: Molybdopterin; pfam00384
573825000446	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
573825000447	4Fe-4S binding domain; Region: Fer4; pfam00037
573825000448	Protein of unknown function (DUF433); Region: DUF433; pfam04255
573825000449	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
573825000450	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825000451	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825000452	DNA binding residues [nucleotide binding]
573825000453	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
573825000454	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
573825000455	catalytic residues [active]
573825000456	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
573825000457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825000458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825000459	homodimer interface [polypeptide binding]; other site
573825000460	catalytic residue [active]
573825000461	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
573825000462	hypothetical protein; Provisional; Region: PRK14391
573825000463	membrane protein insertase; Provisional; Region: PRK01318
573825000464	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
573825000465	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
573825000466	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
573825000467	G-X-X-G motif; other site
573825000468	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
573825000469	RxxxH motif; other site
573825000470	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
573825000471	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
573825000472	trmE is a tRNA modification GTPase; Region: trmE; cd04164
573825000473	G1 box; other site
573825000474	GTP/Mg2+ binding site [chemical binding]; other site
573825000475	Switch I region; other site
573825000476	G2 box; other site
573825000477	Switch II region; other site
573825000478	G3 box; other site
573825000479	G4 box; other site
573825000480	G5 box; other site
573825000481	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
573825000482	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
573825000483	Malic enzyme, N-terminal domain; Region: malic; pfam00390
573825000484	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
573825000485	putative NAD(P) binding site [chemical binding]; other site
573825000486	fumarate hydratase; Reviewed; Region: fumC; PRK00485
573825000487	Class II fumarases; Region: Fumarase_classII; cd01362
573825000488	active site
573825000489	tetramer interface [polypeptide binding]; other site
573825000490	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
573825000491	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352
573825000492	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825000493	non-specific DNA binding site [nucleotide binding]; other site
573825000494	salt bridge; other site
573825000495	sequence-specific DNA binding site [nucleotide binding]; other site
573825000496	Helix-turn-helix domain; Region: HTH_17; pfam12728
573825000497	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
573825000498	Phage Tail Protein X; Region: Phage_tail_X; cl02088
573825000499	Omptin family; Region: Omptin; cl01886
573825000500	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825000501	ligand binding site [chemical binding]; other site
573825000502	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825000503	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
573825000504	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
573825000505	RNA binding surface [nucleotide binding]; other site
573825000506	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
573825000507	active site
573825000508	Predicted amidohydrolase [General function prediction only]; Region: COG0388
573825000509	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
573825000510	putative active site [active]
573825000511	catalytic triad [active]
573825000512	putative dimer interface [polypeptide binding]; other site
573825000513	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
573825000514	classical (c) SDRs; Region: SDR_c; cd05233
573825000515	NAD(P) binding site [chemical binding]; other site
573825000516	active site
573825000517	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
573825000518	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
573825000519	Uncharacterized conserved protein [Function unknown]; Region: COG3339
573825000520	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
573825000521	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
573825000522	active site
573825000523	dimerization interface [polypeptide binding]; other site
573825000524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825000525	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
573825000526	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825000527	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
573825000528	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825000529	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
573825000530	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
573825000531	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
573825000532	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
573825000533	NADP-binding site; other site
573825000534	homotetramer interface [polypeptide binding]; other site
573825000535	substrate binding site [chemical binding]; other site
573825000536	homodimer interface [polypeptide binding]; other site
573825000537	active site
573825000538	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
573825000539	UbiA prenyltransferase family; Region: UbiA; pfam01040
573825000540	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
573825000541	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
573825000542	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
573825000543	Cu(I) binding site [ion binding]; other site
573825000544	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
573825000545	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
573825000546	Cytochrome c; Region: Cytochrom_C; pfam00034
573825000547	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
573825000548	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
573825000549	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
573825000550	Subunit I/III interface [polypeptide binding]; other site
573825000551	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
573825000552	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
573825000553	putative active site [active]
573825000554	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
573825000555	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
573825000556	active site
573825000557	substrate-binding site [chemical binding]; other site
573825000558	metal-binding site [ion binding]
573825000559	ATP binding site [chemical binding]; other site
573825000560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
573825000561	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
573825000562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825000563	P-loop; other site
573825000564	Magnesium ion binding site [ion binding]; other site
573825000565	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825000566	Magnesium ion binding site [ion binding]; other site
573825000567	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
573825000568	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
573825000569	GatB domain; Region: GatB_Yqey; smart00845
573825000570	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
573825000571	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
573825000572	active site
573825000573	PHP Thumb interface [polypeptide binding]; other site
573825000574	metal binding site [ion binding]; metal-binding site
573825000575	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
573825000576	generic binding surface I; other site
573825000577	generic binding surface II; other site
573825000578	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825000579	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825000580	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825000581	CHAT domain; Region: CHAT; cl17868
573825000582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825000583	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825000584	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825000585	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
573825000586	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
573825000587	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
573825000588	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
573825000589	Walker A/P-loop; other site
573825000590	ATP binding site [chemical binding]; other site
573825000591	Q-loop/lid; other site
573825000592	ABC transporter signature motif; other site
573825000593	Walker B; other site
573825000594	D-loop; other site
573825000595	H-loop/switch region; other site
573825000596	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
573825000597	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825000598	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825000599	ligand binding site [chemical binding]; other site
573825000600	flexible hinge region; other site
573825000601	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825000602	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
573825000603	ligand binding site [chemical binding]; other site
573825000604	flexible hinge region; other site
573825000605	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
573825000606	endonuclease III; Region: ENDO3c; smart00478
573825000607	minor groove reading motif; other site
573825000608	helix-hairpin-helix signature motif; other site
573825000609	substrate binding pocket [chemical binding]; other site
573825000610	active site
573825000611	Beta-propeller repeat; Region: SBBP; pfam06739
573825000612	Beta-propeller repeat; Region: SBBP; pfam06739
573825000613	Beta-propeller repeat; Region: SBBP; pfam06739
573825000614	Beta-propeller repeat; Region: SBBP; pfam06739
573825000615	Beta-propeller repeat; Region: SBBP; pfam06739
573825000616	Beta-propeller repeat; Region: SBBP; pfam06739
573825000617	Beta-propeller repeat; Region: SBBP; pfam06739
573825000618	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
573825000619	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825000620	cyclase homology domain; Region: CHD; cd07302
573825000621	nucleotidyl binding site; other site
573825000622	metal binding site [ion binding]; metal-binding site
573825000623	dimer interface [polypeptide binding]; other site
573825000624	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825000625	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825000626	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825000627	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
573825000628	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
573825000629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825000630	S-adenosylmethionine binding site [chemical binding]; other site
573825000631	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
573825000632	AAA domain; Region: AAA_23; pfam13476
573825000633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825000634	ABC transporter signature motif; other site
573825000635	Walker B; other site
573825000636	D-loop; other site
573825000637	H-loop/switch region; other site
573825000638	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
573825000639	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
573825000640	active site
573825000641	metal binding site [ion binding]; metal-binding site
573825000642	DNA binding site [nucleotide binding]
573825000643	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
573825000644	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
573825000645	putative NAD(P) binding site [chemical binding]; other site
573825000646	FOG: CBS domain [General function prediction only]; Region: COG0517
573825000647	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803
573825000648	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
573825000649	HSP70 interaction site [polypeptide binding]; other site
573825000650	Carbon starvation protein CstA; Region: CstA; pfam02554
573825000651	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
573825000652	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
573825000653	Carbon starvation protein CstA; Region: CstA; pfam02554
573825000654	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
573825000655	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
573825000656	nudix motif; other site
573825000657	FlgD Ig-like domain; Region: FlgD_ig; pfam13860
573825000658	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825000659	ligand binding site [chemical binding]; other site
573825000660	NRDE protein; Region: NRDE; cl01315
573825000661	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
573825000662	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825000663	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825000664	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825000665	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
573825000666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825000667	S-adenosylmethionine binding site [chemical binding]; other site
573825000668	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825000669	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
573825000670	ligand binding site [chemical binding]; other site
573825000671	flexible hinge region; other site
573825000672	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825000673	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825000674	ligand binding site [chemical binding]; other site
573825000675	flexible hinge region; other site
573825000676	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825000677	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
573825000678	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
573825000679	active site
573825000680	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825000681	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825000682	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
573825000683	elongation factor G; Reviewed; Region: PRK12740
573825000684	G1 box; other site
573825000685	putative GEF interaction site [polypeptide binding]; other site
573825000686	GTP/Mg2+ binding site [chemical binding]; other site
573825000687	Switch I region; other site
573825000688	G2 box; other site
573825000689	G3 box; other site
573825000690	Switch II region; other site
573825000691	G4 box; other site
573825000692	G5 box; other site
573825000693	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
573825000694	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
573825000695	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
573825000696	Cation transport protein; Region: TrkH; cl17365
573825000697	Cation transport protein; Region: TrkH; cl17365
573825000698	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
573825000699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825000700	non-specific DNA binding site [nucleotide binding]; other site
573825000701	salt bridge; other site
573825000702	sequence-specific DNA binding site [nucleotide binding]; other site
573825000703	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825000704	non-specific DNA binding site [nucleotide binding]; other site
573825000705	salt bridge; other site
573825000706	sequence-specific DNA binding site [nucleotide binding]; other site
573825000707	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
573825000708	UbiA prenyltransferase family; Region: UbiA; pfam01040
573825000709	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
573825000710	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825000711	catalytic residues [active]
573825000712	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
573825000713	putative hydrophobic ligand binding site [chemical binding]; other site
573825000714	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275
573825000715	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
573825000716	putative NAD(P) binding site [chemical binding]; other site
573825000717	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
573825000718	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
573825000719	substrate binding pocket [chemical binding]; other site
573825000720	chain length determination region; other site
573825000721	substrate-Mg2+ binding site; other site
573825000722	catalytic residues [active]
573825000723	aspartate-rich region 1; other site
573825000724	active site lid residues [active]
573825000725	aspartate-rich region 2; other site
573825000726	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
573825000727	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
573825000728	RNA binding surface [nucleotide binding]; other site
573825000729	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
573825000730	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
573825000731	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
573825000732	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
573825000733	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
573825000734	active site
573825000735	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
573825000736	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
573825000737	active site
573825000738	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
573825000739	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
573825000740	Ligand Binding Site [chemical binding]; other site
573825000741	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
573825000742	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
573825000743	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
573825000744	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
573825000745	active site
573825000746	catalytic site [active]
573825000747	metal binding site [ion binding]; metal-binding site
573825000748	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
573825000749	Uncharacterized conserved protein [Function unknown]; Region: COG3791
573825000750	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12729
573825000751	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
573825000752	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
573825000753	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
573825000754	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624
573825000755	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825000756	anti sigma factor interaction site; other site
573825000757	regulatory phosphorylation site [posttranslational modification]; other site
573825000758	TPR repeat; Region: TPR_11; pfam13414
573825000759	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000760	binding surface
573825000761	TPR motif; other site
573825000762	TPR repeat; Region: TPR_11; pfam13414
573825000763	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
573825000764	Protein of unknown function (DUF454); Region: DUF454; pfam04304
573825000765	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
573825000766	glycine dehydrogenase; Provisional; Region: PRK05367
573825000767	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
573825000768	tetramer interface [polypeptide binding]; other site
573825000769	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825000770	catalytic residue [active]
573825000771	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
573825000772	tetramer interface [polypeptide binding]; other site
573825000773	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825000774	catalytic residue [active]
573825000775	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
573825000776	lipoyl attachment site [posttranslational modification]; other site
573825000777	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
573825000778	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
573825000779	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
573825000780	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
573825000781	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
573825000782	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825000783	catalytic residue [active]
573825000784	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
573825000785	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
573825000786	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000787	binding surface
573825000788	TPR motif; other site
573825000789	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825000790	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
573825000791	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
573825000792	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000793	binding surface
573825000794	TPR motif; other site
573825000795	TPR repeat; Region: TPR_11; pfam13414
573825000796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000797	binding surface
573825000798	TPR motif; other site
573825000799	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825000800	Methyltransferase domain; Region: Methyltransf_18; pfam12847
573825000801	KWG Leptospira; Region: KWG; pfam07656
573825000802	KWG Leptospira; Region: KWG; pfam07656
573825000803	KWG Leptospira; Region: KWG; pfam07656
573825000804	Bacterial sugar transferase; Region: Bac_transf; pfam02397
573825000805	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
573825000806	dinuclear metal binding motif [ion binding]; other site
573825000807	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825000808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825000809	active site
573825000810	phosphorylation site [posttranslational modification]
573825000811	intermolecular recognition site; other site
573825000812	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
573825000813	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
573825000814	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
573825000815	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825000816	FeS/SAM binding site; other site
573825000817	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825000818	binding surface
573825000819	TPR motif; other site
573825000820	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
573825000821	Clp amino terminal domain; Region: Clp_N; pfam02861
573825000822	Clp amino terminal domain; Region: Clp_N; pfam02861
573825000823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825000824	Walker A motif; other site
573825000825	ATP binding site [chemical binding]; other site
573825000826	Walker B motif; other site
573825000827	arginine finger; other site
573825000828	UvrB/uvrC motif; Region: UVR; pfam02151
573825000829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825000830	Walker A motif; other site
573825000831	ATP binding site [chemical binding]; other site
573825000832	Walker B motif; other site
573825000833	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
573825000834	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
573825000835	phosphagen binding site; other site
573825000836	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
573825000837	catalytic residues [active]
573825000838	Int/Topo IB signature motif; other site
573825000839	DNA binding site [nucleotide binding]
573825000840	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825000841	anti sigma factor interaction site; other site
573825000842	regulatory phosphorylation site [posttranslational modification]; other site
573825000843	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
573825000844	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
573825000845	active site
573825000846	catalytic triad [active]
573825000847	oxyanion hole [active]
573825000848	Arylesterase; Region: Arylesterase; pfam01731
573825000849	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
573825000850	catalytic core [active]
573825000851	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825000852	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
573825000853	Walker A/P-loop; other site
573825000854	ATP binding site [chemical binding]; other site
573825000855	Q-loop/lid; other site
573825000856	ABC transporter signature motif; other site
573825000857	Walker B; other site
573825000858	D-loop; other site
573825000859	H-loop/switch region; other site
573825000860	HDOD domain; Region: HDOD; pfam08668
573825000861	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825000862	Zn2+ binding site [ion binding]; other site
573825000863	Mg2+ binding site [ion binding]; other site
573825000864	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
573825000865	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
573825000866	Competence protein; Region: Competence; pfam03772
573825000867	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
573825000868	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
573825000869	active site
573825000870	HIGH motif; other site
573825000871	dimer interface [polypeptide binding]; other site
573825000872	KMSKS motif; other site
573825000873	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
573825000874	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
573825000875	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
573825000876	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
573825000877	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
573825000878	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
573825000879	Ligand binding site [chemical binding]; other site
573825000880	Electron transfer flavoprotein domain; Region: ETF; pfam01012
573825000881	isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461
573825000882	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825000883	active site
573825000884	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
573825000885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825000886	S-adenosylmethionine binding site [chemical binding]; other site
573825000887	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825000888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825000889	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825000890	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825000891	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825000892	Putative Ig domain; Region: He_PIG; pfam05345
573825000893	Putative Ig domain; Region: He_PIG; pfam05345
573825000894	Beta-propeller repeat; Region: SBBP; pfam06739
573825000895	Beta-propeller repeat; Region: SBBP; pfam06739
573825000896	Beta-propeller repeat; Region: SBBP; pfam06739
573825000897	Beta-propeller repeat; Region: SBBP; pfam06739
573825000898	Beta-propeller repeat; Region: SBBP; pfam06739
573825000899	Beta-propeller repeat; Region: SBBP; pfam06739
573825000900	Beta-propeller repeat; Region: SBBP; pfam06739
573825000901	Beta-propeller repeat; Region: SBBP; pfam06739
573825000902	Beta-propeller repeat; Region: SBBP; pfam06739
573825000903	Beta-propeller repeat; Region: SBBP; pfam06739
573825000904	Beta-propeller repeat; Region: SBBP; pfam06739
573825000905	Beta-propeller repeat; Region: SBBP; pfam06739
573825000906	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
573825000907	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825000908	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825000909	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825000910	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
573825000911	Predicted transcriptional regulators [Transcription]; Region: COG1695
573825000912	Transcriptional regulator PadR-like family; Region: PadR; cl17335
573825000913	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
573825000914	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825000915	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825000916	active site
573825000917	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
573825000918	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
573825000919	Sm and related proteins; Region: Sm_like; cl00259
573825000920	Sm1 motif; other site
573825000921	hexamer interface [polypeptide binding]; other site
573825000922	heptamer interface [polypeptide binding]; other site
573825000923	RNA binding site [nucleotide binding]; other site
573825000924	Sm2 motif; other site
573825000925	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825000926	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825000927	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825000928	DNA binding residues [nucleotide binding]
573825000929	FecR protein; Region: FecR; pfam04773
573825000930	DoxX; Region: DoxX; pfam07681
573825000931	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
573825000932	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825000933	Walker A/P-loop; other site
573825000934	ATP binding site [chemical binding]; other site
573825000935	Q-loop/lid; other site
573825000936	ABC transporter signature motif; other site
573825000937	Walker B; other site
573825000938	D-loop; other site
573825000939	H-loop/switch region; other site
573825000940	ABC transporter; Region: ABC_tran_2; pfam12848
573825000941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825000942	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
573825000943	active site residue [active]
573825000944	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
573825000945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
573825000946	putative active site [active]
573825000947	putative metal binding site [ion binding]; other site
573825000948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825000949	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825000950	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825000951	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825000952	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825000953	WHG domain; Region: WHG; pfam13305
573825000954	putative acyltransferase; Provisional; Region: PRK05790
573825000955	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
573825000956	dimer interface [polypeptide binding]; other site
573825000957	active site
573825000958	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
573825000959	amidase catalytic site [active]
573825000960	Zn binding residues [ion binding]; other site
573825000961	substrate binding site [chemical binding]; other site
573825000962	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
573825000963	amidase catalytic site [active]
573825000964	Zn binding residues [ion binding]; other site
573825000965	substrate binding site [chemical binding]; other site
573825000966	chromosome segregation protein; Provisional; Region: PRK03918
573825000967	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
573825000968	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
573825000969	homopentamer interface [polypeptide binding]; other site
573825000970	active site
573825000971	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
573825000972	putative RNA binding site [nucleotide binding]; other site
573825000973	TPR repeat; Region: TPR_11; pfam13414
573825000974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000975	TPR motif; other site
573825000976	binding surface
573825000977	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
573825000978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000979	binding surface
573825000980	TPR motif; other site
573825000981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000982	binding surface
573825000983	TPR motif; other site
573825000984	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
573825000985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825000986	binding surface
573825000987	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
573825000988	HEAT repeats; Region: HEAT_2; pfam13646
573825000989	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
573825000990	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
573825000991	active site
573825000992	catalytic residues [active]
573825000993	metal binding site [ion binding]; metal-binding site
573825000994	HEAT repeats; Region: HEAT_2; pfam13646
573825000995	Predicted permeases [General function prediction only]; Region: COG0795
573825000996	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
573825000997	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
573825000998	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
573825000999	NAD(P) binding site [chemical binding]; other site
573825001000	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
573825001001	WYL domain; Region: WYL; pfam13280
573825001002	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
573825001003	Part of AAA domain; Region: AAA_19; pfam13245
573825001004	Family description; Region: UvrD_C_2; pfam13538
573825001005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001006	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001007	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001008	hypothetical protein; Provisional; Region: PRK10318
573825001009	Predicted membrane protein [Function unknown]; Region: COG4270
573825001010	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
573825001011	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825001012	ligand binding site [chemical binding]; other site
573825001013	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
573825001014	Fatty acid desaturase; Region: FA_desaturase; pfam00487
573825001015	putative di-iron ligands [ion binding]; other site
573825001016	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
573825001017	active site
573825001018	DNA polymerase IV; Validated; Region: PRK02406
573825001019	DNA binding site [nucleotide binding]
573825001020	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
573825001021	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825001022	active site
573825001023	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
573825001024	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
573825001025	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
573825001026	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825001027	non-specific DNA binding site [nucleotide binding]; other site
573825001028	salt bridge; other site
573825001029	sequence-specific DNA binding site [nucleotide binding]; other site
573825001030	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
573825001031	trimer interface [polypeptide binding]; other site
573825001032	active site
573825001033	UDP-GlcNAc binding site [chemical binding]; other site
573825001034	lipid binding site [chemical binding]; lipid-binding site
573825001035	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
573825001036	EamA-like transporter family; Region: EamA; pfam00892
573825001037	flavoprotein, HI0933 family; Region: TIGR00275
573825001038	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825001039	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
573825001040	active site
573825001041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825001042	Coenzyme A binding pocket [chemical binding]; other site
573825001043	Predicted membrane protein [Function unknown]; Region: COG2259
573825001044	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
573825001045	MarR family; Region: MarR; pfam01047
573825001046	MarR family; Region: MarR_2; cl17246
573825001047	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
573825001048	Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577
573825001049	active site
573825001050	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
573825001051	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
573825001052	active site
573825001053	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825001054	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
573825001055	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825001056	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
573825001057	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
573825001058	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
573825001059	DJ-1 family protein; Region: not_thiJ; TIGR01383
573825001060	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
573825001061	conserved cys residue [active]
573825001062	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825001063	Coenzyme A binding pocket [chemical binding]; other site
573825001064	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
573825001065	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
573825001066	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
573825001067	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825001068	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
573825001069	YceG-like family; Region: YceG; pfam02618
573825001070	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
573825001071	dimerization interface [polypeptide binding]; other site
573825001072	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
573825001073	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
573825001074	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825001075	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825001076	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825001077	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
573825001078	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825001079	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
573825001080	active site
573825001081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001082	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001083	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001084	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825001085	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825001086	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825001087	cyclase homology domain; Region: CHD; cd07302
573825001088	nucleotidyl binding site; other site
573825001089	metal binding site [ion binding]; metal-binding site
573825001090	dimer interface [polypeptide binding]; other site
573825001091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825001092	NAD(P) binding site [chemical binding]; other site
573825001093	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825001094	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
573825001095	active site
573825001096	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
573825001097	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
573825001098	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
573825001099	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
573825001100	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
573825001101	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
573825001102	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825001103	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
573825001104	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
573825001105	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
573825001106	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
573825001107	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
573825001108	Sulfate transporter family; Region: Sulfate_transp; pfam00916
573825001109	Protein of unknown function (DUF806); Region: DUF806; pfam05657
573825001110	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
573825001111	active site clefts [active]
573825001112	zinc binding site [ion binding]; other site
573825001113	dimer interface [polypeptide binding]; other site
573825001114	Outer membrane efflux protein; Region: OEP; pfam02321
573825001115	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
573825001116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001117	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001118	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001119	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
573825001120	PGAP1-like protein; Region: PGAP1; pfam07819
573825001121	Protein of unknown function (DUF1563); Region: DUF1563; pfam07599
573825001122	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001123	Protein of unknown function (DUF1563); Region: DUF1563; pfam07599
573825001124	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001125	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
573825001126	putative homodimer interface [polypeptide binding]; other site
573825001127	putative homotetramer interface [polypeptide binding]; other site
573825001128	allosteric switch controlling residues; other site
573825001129	putative metal binding site [ion binding]; other site
573825001130	putative homodimer-homodimer interface [polypeptide binding]; other site
573825001131	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
573825001132	metal-binding site [ion binding]
573825001133	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
573825001134	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
573825001135	metal-binding site [ion binding]
573825001136	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
573825001137	Soluble P-type ATPase [General function prediction only]; Region: COG4087
573825001138	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
573825001139	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
573825001140	putative C-terminal domain interface [polypeptide binding]; other site
573825001141	putative GSH binding site (G-site) [chemical binding]; other site
573825001142	putative dimer interface [polypeptide binding]; other site
573825001143	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
573825001144	putative N-terminal domain interface [polypeptide binding]; other site
573825001145	putative dimer interface [polypeptide binding]; other site
573825001146	putative substrate binding pocket (H-site) [chemical binding]; other site
573825001147	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
573825001148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825001149	PAS domain; Region: PAS_9; pfam13426
573825001150	putative active site [active]
573825001151	heme pocket [chemical binding]; other site
573825001152	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
573825001153	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
573825001154	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
573825001155	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825001156	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825001157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825001158	S-adenosylmethionine binding site [chemical binding]; other site
573825001159	SET domain; Region: SET; pfam00856
573825001160	hypothetical protein; Provisional; Region: PRK04164
573825001161	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
573825001162	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
573825001163	mce related protein; Region: MCE; pfam02470
573825001164	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
573825001165	cell division protein FtsA; Region: ftsA; TIGR01174
573825001166	Cell division protein FtsA; Region: FtsA; smart00842
573825001167	Cell division protein FtsA; Region: FtsA; pfam14450
573825001168	cell division protein FtsZ; Validated; Region: PRK09330
573825001169	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
573825001170	nucleotide binding site [chemical binding]; other site
573825001171	SulA interaction site; other site
573825001172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825001173	quinolinate synthetase; Provisional; Region: PRK09375
573825001174	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001175	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
573825001176	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825001177	ATP binding site [chemical binding]; other site
573825001178	putative Mg++ binding site [ion binding]; other site
573825001179	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825001180	nucleotide binding region [chemical binding]; other site
573825001181	ATP-binding site [chemical binding]; other site
573825001182	RQC domain; Region: RQC; pfam09382
573825001183	HRDC domain; Region: HRDC; pfam00570
573825001184	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
573825001185	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
573825001186	DXD motif; other site
573825001187	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
573825001188	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
573825001189	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
573825001190	active site
573825001191	phosphorylation site [posttranslational modification]
573825001192	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
573825001193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
573825001194	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
573825001195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
573825001196	dimer interface [polypeptide binding]; other site
573825001197	conserved gate region; other site
573825001198	putative PBP binding loops; other site
573825001199	ABC-ATPase subunit interface; other site
573825001200	PEGA domain; Region: PEGA; pfam08308
573825001201	PEGA domain; Region: PEGA; pfam08308
573825001202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001203	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001204	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001205	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
573825001206	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
573825001207	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
573825001208	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
573825001209	shikimate binding site; other site
573825001210	NAD(P) binding site [chemical binding]; other site
573825001211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
573825001212	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
573825001213	putative metal binding site; other site
573825001214	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
573825001215	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
573825001216	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825001217	RNA binding site [nucleotide binding]; other site
573825001218	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
573825001219	RNA binding site [nucleotide binding]; other site
573825001220	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
573825001221	RNA binding site [nucleotide binding]; other site
573825001222	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
573825001223	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825001224	excinuclease ABC subunit B; Provisional; Region: PRK05298
573825001225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825001226	ATP binding site [chemical binding]; other site
573825001227	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825001228	nucleotide binding region [chemical binding]; other site
573825001229	ATP-binding site [chemical binding]; other site
573825001230	Ultra-violet resistance protein B; Region: UvrB; pfam12344
573825001231	UvrB/uvrC motif; Region: UVR; pfam02151
573825001232	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
573825001233	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825001234	anti sigma factor interaction site; other site
573825001235	regulatory phosphorylation site [posttranslational modification]; other site
573825001236	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
573825001237	HSP70 interaction site [polypeptide binding]; other site
573825001238	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
573825001239	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
573825001240	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
573825001241	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
573825001242	active site
573825001243	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
573825001244	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
573825001245	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001246	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001247	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
573825001248	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
573825001249	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
573825001250	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
573825001251	Citrate synthase; Region: Citrate_synt; pfam00285
573825001252	oxalacetate binding site [chemical binding]; other site
573825001253	citrylCoA binding site [chemical binding]; other site
573825001254	coenzyme A binding site [chemical binding]; other site
573825001255	catalytic triad [active]
573825001256	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
573825001257	ligand binding site; other site
573825001258	spiro-SPASM protein; Region: spiroSPASM; TIGR04321
573825001259	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825001260	FeS/SAM binding site; other site
573825001261	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
573825001262	SurA N-terminal domain; Region: SurA_N_3; cl07813
573825001263	putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142
573825001264	Cache domain; Region: Cache_1; pfam02743
573825001265	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825001266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825001267	dimerization interface [polypeptide binding]; other site
573825001268	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825001269	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825001270	HAMP domain; Region: HAMP; pfam00672
573825001271	dimerization interface [polypeptide binding]; other site
573825001272	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825001273	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
573825001274	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
573825001275	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
573825001276	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642
573825001277	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
573825001278	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
573825001279	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
573825001280	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
573825001281	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
573825001282	aspartate kinase; Reviewed; Region: PRK06635
573825001283	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
573825001284	putative nucleotide binding site [chemical binding]; other site
573825001285	putative catalytic residues [active]
573825001286	putative Mg ion binding site [ion binding]; other site
573825001287	putative aspartate binding site [chemical binding]; other site
573825001288	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
573825001289	putative allosteric regulatory site; other site
573825001290	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
573825001291	putative allosteric regulatory residue; other site
573825001292	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
573825001293	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
573825001294	Na binding site [ion binding]; other site
573825001295	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825001296	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
573825001297	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
573825001298	metal ion-dependent adhesion site (MIDAS); other site
573825001299	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
573825001300	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
573825001301	Walker A motif; other site
573825001302	ATP binding site [chemical binding]; other site
573825001303	Walker B motif; other site
573825001304	arginine finger; other site
573825001305	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
573825001306	Leucine rich repeat; Region: LRR_8; pfam13855
573825001307	Leucine rich repeat; Region: LRR_8; pfam13855
573825001308	Leucine rich repeat; Region: LRR_8; pfam13855
573825001309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001310	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001311	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001312	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825001313	Leucine rich repeat; Region: LRR_8; pfam13855
573825001314	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825001315	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
573825001316	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825001317	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
573825001318	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
573825001319	protein-splicing catalytic site; other site
573825001320	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
573825001321	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825001322	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
573825001323	Putative Ig domain; Region: He_PIG; pfam05345
573825001324	Integrase core domain; Region: rve_3; pfam13683
573825001325	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
573825001326	hypothetical protein; Validated; Region: PRK00110
573825001327	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
573825001328	active site
573825001329	putative DNA-binding cleft [nucleotide binding]; other site
573825001330	dimer interface [polypeptide binding]; other site
573825001331	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
573825001332	Sulfatase; Region: Sulfatase; pfam00884
573825001333	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
573825001334	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
573825001335	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
573825001336	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
573825001337	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
573825001338	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825001339	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
573825001340	IMP binding site; other site
573825001341	dimer interface [polypeptide binding]; other site
573825001342	interdomain contacts; other site
573825001343	partial ornithine binding site; other site
573825001344	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825001345	pantothenate kinase; Provisional; Region: PTZ00297
573825001346	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
573825001347	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825001348	putative catalytic residue [active]
573825001349	elongation factor G; Reviewed; Region: PRK13351
573825001350	GTP translation factor family primarily contains translation initiation, elongation and release factors; Region: GTP_translation_factor; cd00881
573825001351	G1 box; other site
573825001352	GEF interaction site [polypeptide binding]; other site
573825001353	GTP/Mg2+ binding site [chemical binding]; other site
573825001354	Switch I region; other site
573825001355	G2 box; other site
573825001356	G3 box; other site
573825001357	Switch II region; other site
573825001358	G4 box; other site
573825001359	G5 box; other site
573825001360	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785
573825001361	elongation factor Tu; Reviewed; Region: PRK00049
573825001362	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
573825001363	G1 box; other site
573825001364	GEF interaction site [polypeptide binding]; other site
573825001365	GTP/Mg2+ binding site [chemical binding]; other site
573825001366	Switch I region; other site
573825001367	G2 box; other site
573825001368	G3 box; other site
573825001369	Switch II region; other site
573825001370	G4 box; other site
573825001371	G5 box; other site
573825001372	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
573825001373	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
573825001374	Antibiotic Binding Site [chemical binding]; other site
573825001375	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
573825001376	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
573825001377	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
573825001378	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
573825001379	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
573825001380	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
573825001381	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
573825001382	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
573825001383	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
573825001384	putative translocon binding site; other site
573825001385	protein-rRNA interface [nucleotide binding]; other site
573825001386	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
573825001387	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
573825001388	G-X-X-G motif; other site
573825001389	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
573825001390	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
573825001391	23S rRNA interface [nucleotide binding]; other site
573825001392	5S rRNA interface [nucleotide binding]; other site
573825001393	putative antibiotic binding site [chemical binding]; other site
573825001394	L25 interface [polypeptide binding]; other site
573825001395	L27 interface [polypeptide binding]; other site
573825001396	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
573825001397	putative translocon interaction site; other site
573825001398	23S rRNA interface [nucleotide binding]; other site
573825001399	signal recognition particle (SRP54) interaction site; other site
573825001400	L23 interface [polypeptide binding]; other site
573825001401	trigger factor interaction site; other site
573825001402	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
573825001403	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
573825001404	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
573825001405	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
573825001406	RNA binding site [nucleotide binding]; other site
573825001407	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
573825001408	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
573825001409	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
573825001410	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
573825001411	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
573825001412	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
573825001413	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
573825001414	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
573825001415	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
573825001416	5S rRNA interface [nucleotide binding]; other site
573825001417	L27 interface [polypeptide binding]; other site
573825001418	23S rRNA interface [nucleotide binding]; other site
573825001419	L5 interface [polypeptide binding]; other site
573825001420	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
573825001421	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
573825001422	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
573825001423	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
573825001424	23S rRNA binding site [nucleotide binding]; other site
573825001425	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
573825001426	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
573825001427	SecY translocase; Region: SecY; pfam00344
573825001428	adenylate kinase; Provisional; Region: PRK14528
573825001429	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
573825001430	AMP-binding site [chemical binding]; other site
573825001431	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
573825001432	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
573825001433	rRNA binding site [nucleotide binding]; other site
573825001434	predicted 30S ribosome binding site; other site
573825001435	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
573825001436	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
573825001437	30S ribosomal protein S13; Region: bact_S13; TIGR03631
573825001438	30S ribosomal protein S11; Validated; Region: PRK05309
573825001439	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
573825001440	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
573825001441	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
573825001442	RNA binding surface [nucleotide binding]; other site
573825001443	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
573825001444	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
573825001445	alphaNTD - beta interaction site [polypeptide binding]; other site
573825001446	alphaNTD homodimer interface [polypeptide binding]; other site
573825001447	alphaNTD - beta' interaction site [polypeptide binding]; other site
573825001448	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
573825001449	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
573825001450	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001451	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
573825001452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001453	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001454	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001455	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
573825001456	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825001457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825001458	homodimer interface [polypeptide binding]; other site
573825001459	catalytic residue [active]
573825001460	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
573825001461	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
573825001462	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
573825001463	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
573825001464	Fatty acid desaturase; Region: FA_desaturase; pfam00487
573825001465	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
573825001466	putative di-iron ligands [ion binding]; other site
573825001467	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
573825001468	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
573825001469	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
573825001470	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
573825001471	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
573825001472	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
573825001473	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
573825001474	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
573825001475	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
573825001476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825001477	S-adenosylmethionine binding site [chemical binding]; other site
573825001478	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
573825001479	putative RNA binding site [nucleotide binding]; other site
573825001480	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
573825001481	dimer interface [polypeptide binding]; other site
573825001482	Citrate synthase; Region: Citrate_synt; pfam00285
573825001483	active site
573825001484	citrylCoA binding site [chemical binding]; other site
573825001485	NADH binding [chemical binding]; other site
573825001486	cationic pore residues; other site
573825001487	oxalacetate/citrate binding site [chemical binding]; other site
573825001488	coenzyme A binding site [chemical binding]; other site
573825001489	catalytic triad [active]
573825001490	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
573825001491	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
573825001492	N-acetyl-D-glucosamine binding site [chemical binding]; other site
573825001493	catalytic residue [active]
573825001494	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825001495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
573825001496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825001497	Coenzyme A binding pocket [chemical binding]; other site
573825001498	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
573825001499	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
573825001500	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
573825001501	TPR repeat; Region: TPR_11; pfam13414
573825001502	TPR repeat; Region: TPR_11; pfam13414
573825001503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001504	binding surface
573825001505	TPR motif; other site
573825001506	TPR repeat; Region: TPR_11; pfam13414
573825001507	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
573825001508	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
573825001509	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
573825001510	TMP-binding site; other site
573825001511	ATP-binding site [chemical binding]; other site
573825001512	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
573825001513	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
573825001514	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825001515	protein binding site [polypeptide binding]; other site
573825001516	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
573825001517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825001518	Walker A motif; other site
573825001519	ATP binding site [chemical binding]; other site
573825001520	Walker B motif; other site
573825001521	arginine finger; other site
573825001522	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
573825001523	Gram-negative bacterial tonB protein; Region: TonB; cl10048
573825001524	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
573825001525	PIN domain; Region: PIN; pfam01850
573825001526	putative active site [active]
573825001527	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825001528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
573825001529	Histidine kinase; Region: HisKA_3; pfam07730
573825001530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
573825001531	ATP binding site [chemical binding]; other site
573825001532	Mg2+ binding site [ion binding]; other site
573825001533	G-X-G motif; other site
573825001534	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
573825001535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825001536	active site
573825001537	phosphorylation site [posttranslational modification]
573825001538	intermolecular recognition site; other site
573825001539	dimerization interface [polypeptide binding]; other site
573825001540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
573825001541	DNA binding residues [nucleotide binding]
573825001542	dimerization interface [polypeptide binding]; other site
573825001543	NAD-dependent deacetylase; Provisional; Region: PRK00481
573825001544	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
573825001545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825001546	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825001547	methionine sulfoxide reductase B; Provisional; Region: PRK00222
573825001548	SelR domain; Region: SelR; pfam01641
573825001549	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825001550	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825001551	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825001552	active site
573825001553	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
573825001554	active site 2 [active]
573825001555	active site 1 [active]
573825001556	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
573825001557	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
573825001558	dimer interface [polypeptide binding]; other site
573825001559	active site
573825001560	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
573825001561	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
573825001562	pantothenate kinase; Reviewed; Region: PRK13318
573825001563	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001564	Protein of unknown function (DUF1563); Region: DUF1563; pfam07599
573825001565	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
573825001566	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825001567	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825001568	anti sigma factor interaction site; other site
573825001569	regulatory phosphorylation site [posttranslational modification]; other site
573825001570	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
573825001571	active site
573825001572	ribulose/triose binding site [chemical binding]; other site
573825001573	phosphate binding site [ion binding]; other site
573825001574	substrate (anthranilate) binding pocket [chemical binding]; other site
573825001575	product (indole) binding pocket [chemical binding]; other site
573825001576	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14465
573825001577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825001578	FeS/SAM binding site; other site
573825001579	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
573825001580	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
573825001581	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
573825001582	active site
573825001583	catalytic residues [active]
573825001584	metal binding site [ion binding]; metal-binding site
573825001585	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
573825001586	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825001587	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
573825001588	dimer interface [polypeptide binding]; other site
573825001589	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
573825001590	dimer interface [polypeptide binding]; other site
573825001591	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
573825001592	hypothetical protein; Provisional; Region: PRK14553
573825001593	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
573825001594	GTPase CgtA; Reviewed; Region: obgE; PRK12299
573825001595	GTP1/OBG; Region: GTP1_OBG; pfam01018
573825001596	Obg GTPase; Region: Obg; cd01898
573825001597	G1 box; other site
573825001598	GTP/Mg2+ binding site [chemical binding]; other site
573825001599	Switch I region; other site
573825001600	G2 box; other site
573825001601	G3 box; other site
573825001602	Switch II region; other site
573825001603	G4 box; other site
573825001604	G5 box; other site
573825001605	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
573825001606	nucleotide binding site [chemical binding]; other site
573825001607	homotetrameric interface [polypeptide binding]; other site
573825001608	putative phosphate binding site [ion binding]; other site
573825001609	putative allosteric binding site; other site
573825001610	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
573825001611	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
573825001612	putative catalytic cysteine [active]
573825001613	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
573825001614	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
573825001615	active site
573825001616	(T/H)XGH motif; other site
573825001617	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001618	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001619	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825001620	anti sigma factor interaction site; other site
573825001621	regulatory phosphorylation site [posttranslational modification]; other site
573825001622	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
573825001623	dimer interface [polypeptide binding]; other site
573825001624	catalytic triad [active]
573825001625	peroxidatic and resolving cysteines [active]
573825001626	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
573825001627	PYR/PP interface [polypeptide binding]; other site
573825001628	dimer interface [polypeptide binding]; other site
573825001629	TPP binding site [chemical binding]; other site
573825001630	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
573825001631	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
573825001632	dimer interface [polypeptide binding]; other site
573825001633	TPP-binding site [chemical binding]; other site
573825001634	HDOD domain; Region: HDOD; pfam08668
573825001635	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
573825001636	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
573825001637	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
573825001638	NAD(P) binding site [chemical binding]; other site
573825001639	catalytic residues [active]
573825001640	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
573825001641	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
573825001642	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825001643	Leucine-rich repeats; other site
573825001644	Leucine rich repeat; Region: LRR_8; pfam13855
573825001645	Substrate binding site [chemical binding]; other site
573825001646	Leucine rich repeat; Region: LRR_8; pfam13855
573825001647	Leucine rich repeat; Region: LRR_8; pfam13855
573825001648	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825001649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825001650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825001651	DNA binding residues [nucleotide binding]
573825001652	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
573825001653	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
573825001654	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
573825001655	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
573825001656	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
573825001657	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
573825001658	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
573825001659	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
573825001660	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
573825001661	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
573825001662	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
573825001663	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
573825001664	SLBB domain; Region: SLBB; pfam10531
573825001665	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
573825001666	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
573825001667	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
573825001668	putative dimer interface [polypeptide binding]; other site
573825001669	[2Fe-2S] cluster binding site [ion binding]; other site
573825001670	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
573825001671	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
573825001672	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
573825001673	NADH dehydrogenase subunit B; Provisional; Region: PRK14814
573825001674	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
573825001675	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
573825001676	putative active site [active]
573825001677	putative catalytic site [active]
573825001678	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
573825001679	MarR family; Region: MarR_2; pfam12802
573825001680	MarR family; Region: MarR_2; cl17246
573825001681	Methyltransferase domain; Region: Methyltransf_26; pfam13659
573825001682	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
573825001683	heme-binding site [chemical binding]; other site
573825001684	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
573825001685	active site
573825001686	dimer interfaces [polypeptide binding]; other site
573825001687	catalytic residues [active]
573825001688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001689	binding surface
573825001690	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825001691	TPR motif; other site
573825001692	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001693	TPR motif; other site
573825001694	binding surface
573825001695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001696	binding surface
573825001697	Uncharacterized conserved protein [Function unknown]; Region: COG3391
573825001698	NHL repeat; Region: NHL; pfam01436
573825001699	NHL repeat; Region: NHL; pfam01436
573825001700	von Willebrand factor type A domain; Region: VWA_2; pfam13519
573825001701	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825001702	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
573825001703	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
573825001704	active site
573825001705	Zn binding site [ion binding]; other site
573825001706	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
573825001707	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
573825001708	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825001709	substrate binding site [chemical binding]; other site
573825001710	oxyanion hole (OAH) forming residues; other site
573825001711	trimer interface [polypeptide binding]; other site
573825001712	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
573825001713	PilZ domain; Region: PilZ; pfam07238
573825001714	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001715	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001716	TPR repeat; Region: TPR_11; pfam13414
573825001717	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
573825001718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825001719	Major Facilitator Superfamily; Region: MFS_1; pfam07690
573825001720	putative substrate translocation pore; other site
573825001721	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
573825001722	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825001723	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
573825001724	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825001725	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
573825001726	putative active site [active]
573825001727	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
573825001728	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
573825001729	putative substrate binding site [chemical binding]; other site
573825001730	putative ATP binding site [chemical binding]; other site
573825001731	hypothetical protein; Provisional; Region: PRK14635
573825001732	NusA N-terminal domain; Region: NusA_N; pfam08529
573825001733	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
573825001734	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
573825001735	RNA binding site [nucleotide binding]; other site
573825001736	homodimer interface [polypeptide binding]; other site
573825001737	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
573825001738	G-X-X-G motif; other site
573825001739	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
573825001740	G-X-X-G motif; other site
573825001741	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
573825001742	translation initiation factor IF-2; Region: IF-2; TIGR00487
573825001743	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
573825001744	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
573825001745	G1 box; other site
573825001746	putative GEF interaction site [polypeptide binding]; other site
573825001747	GTP/Mg2+ binding site [chemical binding]; other site
573825001748	Switch I region; other site
573825001749	G2 box; other site
573825001750	G3 box; other site
573825001751	Switch II region; other site
573825001752	G4 box; other site
573825001753	G5 box; other site
573825001754	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
573825001755	Translation-initiation factor 2; Region: IF-2; pfam11987
573825001756	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
573825001757	Ribosome-binding factor A; Region: RBFA; pfam02033
573825001758	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
573825001759	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
573825001760	active site
573825001761	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
573825001762	16S/18S rRNA binding site [nucleotide binding]; other site
573825001763	S13e-L30e interaction site [polypeptide binding]; other site
573825001764	25S rRNA binding site [nucleotide binding]; other site
573825001765	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
573825001766	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
573825001767	RNase E interface [polypeptide binding]; other site
573825001768	trimer interface [polypeptide binding]; other site
573825001769	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
573825001770	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
573825001771	RNase E interface [polypeptide binding]; other site
573825001772	trimer interface [polypeptide binding]; other site
573825001773	active site
573825001774	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
573825001775	putative nucleic acid binding region [nucleotide binding]; other site
573825001776	G-X-X-G motif; other site
573825001777	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
573825001778	RNA binding site [nucleotide binding]; other site
573825001779	domain interface; other site
573825001780	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
573825001781	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
573825001782	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
573825001783	Rhomboid family; Region: Rhomboid; pfam01694
573825001784	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
573825001785	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
573825001786	active site
573825001787	dimer interface [polypeptide binding]; other site
573825001788	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
573825001789	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
573825001790	active site
573825001791	FMN binding site [chemical binding]; other site
573825001792	substrate binding site [chemical binding]; other site
573825001793	3Fe-4S cluster binding site [ion binding]; other site
573825001794	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
573825001795	domain interface; other site
573825001796	Outer membrane efflux protein; Region: OEP; pfam02321
573825001797	Outer membrane efflux protein; Region: OEP; pfam02321
573825001798	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
573825001799	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
573825001800	catalytic residues [active]
573825001801	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
573825001802	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
573825001803	putative hydrophobic ligand binding site [chemical binding]; other site
573825001804	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825001805	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
573825001806	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825001807	ATP binding site [chemical binding]; other site
573825001808	putative Mg++ binding site [ion binding]; other site
573825001809	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825001810	nucleotide binding region [chemical binding]; other site
573825001811	ATP-binding site [chemical binding]; other site
573825001812	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
573825001813	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
573825001814	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
573825001815	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
573825001816	Part of AAA domain; Region: AAA_19; pfam13245
573825001817	Family description; Region: UvrD_C_2; pfam13538
573825001818	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
573825001819	AAA domain; Region: AAA_30; pfam13604
573825001820	AAA domain; Region: AAA_11; pfam13086
573825001821	Family description; Region: UvrD_C_2; pfam13538
573825001822	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825001823	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
573825001824	Walker A/P-loop; other site
573825001825	ATP binding site [chemical binding]; other site
573825001826	Q-loop/lid; other site
573825001827	ABC transporter signature motif; other site
573825001828	Walker B; other site
573825001829	D-loop; other site
573825001830	H-loop/switch region; other site
573825001831	ABC-2 type transporter; Region: ABC2_membrane; cl17235
573825001832	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
573825001833	short chain dehydrogenase; Provisional; Region: PRK05872
573825001834	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
573825001835	putative NAD(P) binding site [chemical binding]; other site
573825001836	homotetramer interface [polypeptide binding]; other site
573825001837	active site
573825001838	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
573825001839	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001840	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825001841	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
573825001842	ThiC family; Region: ThiC; pfam01964
573825001843	KWG Leptospira; Region: KWG; pfam07656
573825001844	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825001845	WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998
573825001846	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846
573825001847	active site
573825001848	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
573825001849	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825001850	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
573825001851	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
573825001852	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
573825001853	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
573825001854	Mechanosensitive ion channel; Region: MS_channel; pfam00924
573825001855	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825001856	dimerization interface [polypeptide binding]; other site
573825001857	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
573825001858	cyclase homology domain; Region: CHD; cd07302
573825001859	nucleotidyl binding site; other site
573825001860	metal binding site [ion binding]; metal-binding site
573825001861	dimer interface [polypeptide binding]; other site
573825001862	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
573825001863	Interdomain contacts; other site
573825001864	Cytokine receptor motif; other site
573825001865	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825001866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825001867	Coenzyme A binding pocket [chemical binding]; other site
573825001868	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
573825001869	oligomeric interface; other site
573825001870	putative active site [active]
573825001871	homodimer interface [polypeptide binding]; other site
573825001872	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
573825001873	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
573825001874	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825001875	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825001876	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825001877	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
573825001878	catalytic residues [active]
573825001879	dimer interface [polypeptide binding]; other site
573825001880	Protein of unknown function, DUF399; Region: DUF399; pfam04187
573825001881	Transglycosylase; Region: Transgly; pfam00912
573825001882	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
573825001883	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
573825001884	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
573825001885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001886	binding surface
573825001887	TPR motif; other site
573825001888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001889	binding surface
573825001890	TPR motif; other site
573825001891	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825001892	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
573825001893	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
573825001894	trimerization site [polypeptide binding]; other site
573825001895	active site
573825001896	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
573825001897	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
573825001898	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
573825001899	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
573825001900	transcription termination factor Rho; Provisional; Region: rho; PRK09376
573825001901	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
573825001902	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
573825001903	RNA binding site [nucleotide binding]; other site
573825001904	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
573825001905	multimer interface [polypeptide binding]; other site
573825001906	Walker A motif; other site
573825001907	ATP binding site [chemical binding]; other site
573825001908	Walker B motif; other site
573825001909	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
573825001910	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
573825001911	Uncharacterized conserved protein [Function unknown]; Region: COG5276
573825001912	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
573825001913	putative catalytic site [active]
573825001914	metal binding site A [ion binding]; metal-binding site
573825001915	phosphate binding site [ion binding]; other site
573825001916	metal binding site C [ion binding]; metal-binding site
573825001917	metal binding site B [ion binding]; metal-binding site
573825001918	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
573825001919	putative catalytic site [active]
573825001920	metal binding site A [ion binding]; metal-binding site
573825001921	phosphate binding site [ion binding]; other site
573825001922	metal binding site C [ion binding]; metal-binding site
573825001923	metal binding site B [ion binding]; metal-binding site
573825001924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825001925	binding surface
573825001926	TPR motif; other site
573825001927	TPR repeat; Region: TPR_11; pfam13414
573825001928	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825001929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825001930	binding surface
573825001931	TPR motif; other site
573825001932	enoyl-CoA hydratase; Provisional; Region: PRK06142
573825001933	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825001934	substrate binding site [chemical binding]; other site
573825001935	oxyanion hole (OAH) forming residues; other site
573825001936	trimer interface [polypeptide binding]; other site
573825001937	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825001938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825001939	active site
573825001940	phosphorylation site [posttranslational modification]
573825001941	intermolecular recognition site; other site
573825001942	dimerization interface [polypeptide binding]; other site
573825001943	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825001944	PAS domain; Region: PAS_9; pfam13426
573825001945	putative active site [active]
573825001946	heme pocket [chemical binding]; other site
573825001947	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825001948	Histidine kinase; Region: HisKA_2; pfam07568
573825001949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825001950	ATP binding site [chemical binding]; other site
573825001951	Mg2+ binding site [ion binding]; other site
573825001952	G-X-G motif; other site
573825001953	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
573825001954	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825001955	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825001956	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825001957	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825001958	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
573825001959	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
573825001960	Transglycosylase; Region: Transgly; pfam00912
573825001961	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
573825001962	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
573825001963	diaminopimelate decarboxylase; Provisional; Region: PRK11165
573825001964	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
573825001965	active site
573825001966	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
573825001967	substrate binding site [chemical binding]; other site
573825001968	catalytic residues [active]
573825001969	dimer interface [polypeptide binding]; other site
573825001970	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
573825001971	substrate binding site; other site
573825001972	dimer interface; other site
573825001973	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
573825001974	tail protein; Region: PHA00965
573825001975	Baseplate J-like protein; Region: Baseplate_J; cl01294
573825001976	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
573825001977	Putative pectinesterase/pectinesterase inhibitor; Region: PLN02745
573825001978	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
573825001979	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825001980	Heme NO binding associated; Region: HNOBA; pfam07701
573825001981	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
573825001982	cyclase homology domain; Region: CHD; cd07302
573825001983	nucleotidyl binding site; other site
573825001984	metal binding site [ion binding]; metal-binding site
573825001985	dimer interface [polypeptide binding]; other site
573825001986	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825001987	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
573825001988	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
573825001989	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
573825001990	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
573825001991	Zn binding site [ion binding]; other site
573825001992	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825001993	H+ Antiporter protein; Region: 2A0121; TIGR00900
573825001994	putative substrate translocation pore; other site
573825001995	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
573825001996	dimer interface [polypeptide binding]; other site
573825001997	ADP-ribose binding site [chemical binding]; other site
573825001998	active site
573825001999	nudix motif; other site
573825002000	metal binding site [ion binding]; metal-binding site
573825002001	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
573825002002	Part of AAA domain; Region: AAA_19; pfam13245
573825002003	Family description; Region: UvrD_C_2; pfam13538
573825002004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825002005	binding surface
573825002006	TPR motif; other site
573825002007	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
573825002008	dimerization interface [polypeptide binding]; other site
573825002009	putative DNA binding site [nucleotide binding]; other site
573825002010	putative Zn2+ binding site [ion binding]; other site
573825002011	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
573825002012	putative hydrophobic ligand binding site [chemical binding]; other site
573825002013	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825002014	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
573825002015	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
573825002016	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
573825002017	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
573825002018	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
573825002019	Bacterial SH3 domain; Region: SH3_3; pfam08239
573825002020	Outer membrane efflux protein; Region: OEP; pfam02321
573825002021	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
573825002022	CoA binding domain; Region: CoA_binding; smart00881
573825002023	CoA-ligase; Region: Ligase_CoA; pfam00549
573825002024	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
573825002025	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
573825002026	CoA-ligase; Region: Ligase_CoA; pfam00549
573825002027	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
573825002028	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14332
573825002029	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
573825002030	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825002031	FeS/SAM binding site; other site
573825002032	TRAM domain; Region: TRAM; cl01282
573825002033	Predicted permeases [General function prediction only]; Region: COG0795
573825002034	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
573825002035	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
573825002036	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
573825002037	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
573825002038	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
573825002039	GDP-binding site [chemical binding]; other site
573825002040	ACT binding site; other site
573825002041	IMP binding site; other site
573825002042	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
573825002043	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
573825002044	motif 1; other site
573825002045	dimer interface [polypeptide binding]; other site
573825002046	active site
573825002047	motif 2; other site
573825002048	motif 3; other site
573825002049	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
573825002050	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
573825002051	putative acyl-acceptor binding pocket; other site
573825002052	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
573825002053	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
573825002054	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
573825002055	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
573825002056	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
573825002057	[2Fe-2S] cluster binding site [ion binding]; other site
573825002058	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
573825002059	putative alpha subunit interface [polypeptide binding]; other site
573825002060	putative active site [active]
573825002061	putative substrate binding site [chemical binding]; other site
573825002062	Fe binding site [ion binding]; other site
573825002063	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
573825002064	trimer interface [polypeptide binding]; other site
573825002065	active site
573825002066	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825002067	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
573825002068	RNase_H superfamily; Region: RNase_H_2; pfam13482
573825002069	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
573825002070	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
573825002071	putative active site [active]
573825002072	catalytic triad [active]
573825002073	putative dimer interface [polypeptide binding]; other site
573825002074	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
573825002075	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
573825002076	ligand binding site [chemical binding]; other site
573825002077	NAD binding site [chemical binding]; other site
573825002078	catalytic site [active]
573825002079	homodimer interface [polypeptide binding]; other site
573825002080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825002081	Radical SAM superfamily; Region: Radical_SAM; pfam04055
573825002082	FeS/SAM binding site; other site
573825002083	A new structural DNA glycosylase; Region: AlkD_like; cl11434
573825002084	active site
573825002085	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825002086	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
573825002087	active site
573825002088	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
573825002089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825002090	S-adenosylmethionine binding site [chemical binding]; other site
573825002091	AAA domain; Region: AAA_33; pfam13671
573825002092	AAA domain; Region: AAA_17; pfam13207
573825002093	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
573825002094	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
573825002095	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
573825002096	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
573825002097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825002098	non-specific DNA binding site [nucleotide binding]; other site
573825002099	salt bridge; other site
573825002100	sequence-specific DNA binding site [nucleotide binding]; other site
573825002101	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
573825002102	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
573825002103	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
573825002104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825002105	FeS/SAM binding site; other site
573825002106	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
573825002107	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
573825002108	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
573825002109	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
573825002110	Preprotein translocase subunit; Region: YajC; pfam02699
573825002111	protein-export membrane protein SecD; Region: secD; TIGR01129
573825002112	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
573825002113	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
573825002114	Protein export membrane protein; Region: SecD_SecF; pfam02355
573825002115	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
573825002116	catalytic motif [active]
573825002117	Zn binding site [ion binding]; other site
573825002118	RibD C-terminal domain; Region: RibD_C; cl17279
573825002119	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
573825002120	Lumazine binding domain; Region: Lum_binding; pfam00677
573825002121	Lumazine binding domain; Region: Lum_binding; pfam00677
573825002122	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
573825002123	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
573825002124	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
573825002125	dimerization interface [polypeptide binding]; other site
573825002126	active site
573825002127	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
573825002128	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
573825002129	substrate binding pocket [chemical binding]; other site
573825002130	membrane-bound complex binding site; other site
573825002131	hinge residues; other site
573825002132	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
573825002133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
573825002134	dimer interface [polypeptide binding]; other site
573825002135	conserved gate region; other site
573825002136	putative PBP binding loops; other site
573825002137	ABC-ATPase subunit interface; other site
573825002138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
573825002139	dimer interface [polypeptide binding]; other site
573825002140	conserved gate region; other site
573825002141	putative PBP binding loops; other site
573825002142	ABC-ATPase subunit interface; other site
573825002143	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
573825002144	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
573825002145	Walker A/P-loop; other site
573825002146	ATP binding site [chemical binding]; other site
573825002147	Q-loop/lid; other site
573825002148	ABC transporter signature motif; other site
573825002149	Walker B; other site
573825002150	D-loop; other site
573825002151	H-loop/switch region; other site
573825002152	TOBE-like domain; Region: TOBE_3; pfam12857
573825002153	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825002154	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825002155	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
573825002156	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
573825002157	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
573825002158	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
573825002159	active site
573825002160	ATP binding site [chemical binding]; other site
573825002161	substrate binding site [chemical binding]; other site
573825002162	activation loop (A-loop); other site
573825002163	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
573825002164	AAA ATPase domain; Region: AAA_16; pfam13191
573825002165	Predicted ATPase [General function prediction only]; Region: COG3899
573825002166	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825002167	GAF domain; Region: GAF; pfam01590
573825002168	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825002169	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825002170	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
573825002171	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
573825002172	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
573825002173	Peptidase family M48; Region: Peptidase_M48; cl12018
573825002174	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
573825002175	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
573825002176	acyl-activating enzyme (AAE) consensus motif; other site
573825002177	putative AMP binding site [chemical binding]; other site
573825002178	putative active site [active]
573825002179	putative CoA binding site [chemical binding]; other site
573825002180	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
573825002181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
573825002182	substrate binding pocket [chemical binding]; other site
573825002183	membrane-bound complex binding site; other site
573825002184	hinge residues; other site
573825002185	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
573825002186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825002187	ATP binding site [chemical binding]; other site
573825002188	Mg2+ binding site [ion binding]; other site
573825002189	G-X-G motif; other site
573825002190	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
573825002191	ATP binding site [chemical binding]; other site
573825002192	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
573825002193	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
573825002194	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
573825002195	recombination factor protein RarA; Reviewed; Region: PRK13342
573825002196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825002197	Walker A motif; other site
573825002198	ATP binding site [chemical binding]; other site
573825002199	Walker B motif; other site
573825002200	arginine finger; other site
573825002201	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
573825002202	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
573825002203	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825002204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825002205	homodimer interface [polypeptide binding]; other site
573825002206	catalytic residue [active]
573825002207	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
573825002208	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
573825002209	catalytic loop [active]
573825002210	iron binding site [ion binding]; other site
573825002211	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825002212	cyclase homology domain; Region: CHD; cd07302
573825002213	nucleotidyl binding site; other site
573825002214	metal binding site [ion binding]; metal-binding site
573825002215	dimer interface [polypeptide binding]; other site
573825002216	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cd00314
573825002217	heme binding site [chemical binding]; other site
573825002218	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002220	active site
573825002221	phosphorylation site [posttranslational modification]
573825002222	intermolecular recognition site; other site
573825002223	dimerization interface [polypeptide binding]; other site
573825002224	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825002225	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825002226	metal binding site [ion binding]; metal-binding site
573825002227	active site
573825002228	I-site; other site
573825002229	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825002230	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002232	active site
573825002233	phosphorylation site [posttranslational modification]
573825002234	intermolecular recognition site; other site
573825002235	dimerization interface [polypeptide binding]; other site
573825002236	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825002237	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
573825002238	30S subunit binding site; other site
573825002239	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825002240	binding surface
573825002241	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825002242	TPR motif; other site
573825002243	Cache domain; Region: Cache_1; pfam02743
573825002244	HAMP domain; Region: HAMP; pfam00672
573825002245	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825002246	dimer interface [polypeptide binding]; other site
573825002247	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
573825002248	putative CheW interface [polypeptide binding]; other site
573825002249	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825002250	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
573825002251	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825002252	substrate binding site [chemical binding]; other site
573825002253	oxyanion hole (OAH) forming residues; other site
573825002254	trimer interface [polypeptide binding]; other site
573825002255	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
573825002256	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
573825002257	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825002258	PilZ domain; Region: PilZ; pfam07238
573825002259	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
573825002260	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825002261	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825002262	DNA binding residues [nucleotide binding]
573825002263	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825002264	active site
573825002265	Peptidase family C69; Region: Peptidase_C69; cl17793
573825002266	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
573825002267	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
573825002268	putative catalytic residues [active]
573825002269	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
573825002270	Ligand Binding Site [chemical binding]; other site
573825002271	HAMP domain; Region: HAMP; pfam00672
573825002272	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
573825002273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825002274	dimer interface [polypeptide binding]; other site
573825002275	putative CheW interface [polypeptide binding]; other site
573825002276	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
573825002277	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825002278	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
573825002279	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
573825002280	Transglycosylase; Region: Transgly; pfam00912
573825002281	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
573825002282	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
573825002283	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
573825002284	E3 interaction surface; other site
573825002285	lipoyl attachment site [posttranslational modification]; other site
573825002286	e3 binding domain; Region: E3_binding; pfam02817
573825002287	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
573825002288	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
573825002289	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
573825002290	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825002291	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
573825002292	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
573825002293	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
573825002294	TPP-binding site [chemical binding]; other site
573825002295	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
573825002296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
573825002297	HSP90 family protein; Provisional; Region: PRK14083
573825002298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825002299	ATP binding site [chemical binding]; other site
573825002300	Mg2+ binding site [ion binding]; other site
573825002301	G-X-G motif; other site
573825002302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825002303	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825002304	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002305	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825002306	binding surface
573825002307	TPR motif; other site
573825002308	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
573825002309	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
573825002310	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
573825002311	catalytic site [active]
573825002312	subunit interface [polypeptide binding]; other site
573825002313	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
573825002314	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
573825002315	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
573825002316	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
573825002317	active site
573825002318	dimer interface [polypeptide binding]; other site
573825002319	motif 1; other site
573825002320	motif 2; other site
573825002321	motif 3; other site
573825002322	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
573825002323	anticodon binding site; other site
573825002324	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
573825002325	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
573825002326	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
573825002327	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
573825002328	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
573825002329	23S rRNA binding site [nucleotide binding]; other site
573825002330	L21 binding site [polypeptide binding]; other site
573825002331	L13 binding site [polypeptide binding]; other site
573825002332	Protein of unknown function (DUF904); Region: DUF904; cl11531
573825002333	Cell division protein ZapA; Region: ZapA; pfam05164
573825002334	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
573825002335	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
573825002336	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
573825002337	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
573825002338	putative binding surface; other site
573825002339	active site
573825002340	P2 response regulator binding domain; Region: P2; pfam07194
573825002341	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
573825002342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825002343	ATP binding site [chemical binding]; other site
573825002344	Mg2+ binding site [ion binding]; other site
573825002345	G-X-G motif; other site
573825002346	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
573825002347	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
573825002348	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
573825002349	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
573825002350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002351	active site
573825002352	phosphorylation site [posttranslational modification]
573825002353	intermolecular recognition site; other site
573825002354	dimerization interface [polypeptide binding]; other site
573825002355	CheB methylesterase; Region: CheB_methylest; pfam01339
573825002356	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002358	active site
573825002359	phosphorylation site [posttranslational modification]
573825002360	intermolecular recognition site; other site
573825002361	dimerization interface [polypeptide binding]; other site
573825002362	ScpA/B protein; Region: ScpA_ScpB; cl00598
573825002363	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
573825002364	Chorismate mutase type II; Region: CM_2; pfam01817
573825002365	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
573825002366	Prephenate dehydratase; Region: PDT; pfam00800
573825002367	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
573825002368	putative L-Phe binding site [chemical binding]; other site
573825002369	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
573825002370	prephenate dehydrogenase; Validated; Region: PRK08507
573825002371	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
573825002372	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
573825002373	hinge; other site
573825002374	active site
573825002375	cytidylate kinase; Provisional; Region: cmk; PRK00023
573825002376	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
573825002377	CMP-binding site; other site
573825002378	The sites determining sugar specificity; other site
573825002379	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
573825002380	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
573825002381	RNA binding site [nucleotide binding]; other site
573825002382	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
573825002383	RNA binding site [nucleotide binding]; other site
573825002384	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825002385	RNA binding site [nucleotide binding]; other site
573825002386	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825002387	RNA binding site [nucleotide binding]; other site
573825002388	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825002389	RNA binding site [nucleotide binding]; other site
573825002390	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
573825002391	RNA binding site [nucleotide binding]; other site
573825002392	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825002393	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
573825002394	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
573825002395	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
573825002396	putative phosphate acyltransferase; Provisional; Region: PRK05331
573825002397	Sulfatase; Region: Sulfatase; pfam00884
573825002398	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
573825002399	Sulfatase; Region: Sulfatase; pfam00884
573825002400	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825002401	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825002402	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
573825002403	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
573825002404	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
573825002405	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
573825002406	FtsX-like permease family; Region: FtsX; pfam02687
573825002407	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
573825002408	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
573825002409	Walker A/P-loop; other site
573825002410	ATP binding site [chemical binding]; other site
573825002411	Q-loop/lid; other site
573825002412	ABC transporter signature motif; other site
573825002413	Walker B; other site
573825002414	D-loop; other site
573825002415	H-loop/switch region; other site
573825002416	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
573825002417	Uncharacterized conserved protein [Function unknown]; Region: COG4715
573825002418	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
573825002419	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
573825002420	aspartate aminotransferase; Provisional; Region: PRK05764
573825002421	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825002422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825002423	homodimer interface [polypeptide binding]; other site
573825002424	catalytic residue [active]
573825002425	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
573825002426	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
573825002427	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825002428	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825002429	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002430	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825002431	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002432	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002433	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
573825002434	SmpB-tmRNA interface; other site
573825002435	GTP-binding protein Der; Reviewed; Region: PRK00093
573825002436	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
573825002437	G1 box; other site
573825002438	GTP/Mg2+ binding site [chemical binding]; other site
573825002439	Switch I region; other site
573825002440	G2 box; other site
573825002441	Switch II region; other site
573825002442	G3 box; other site
573825002443	G4 box; other site
573825002444	G5 box; other site
573825002445	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
573825002446	G1 box; other site
573825002447	GTP/Mg2+ binding site [chemical binding]; other site
573825002448	Switch I region; other site
573825002449	G2 box; other site
573825002450	G3 box; other site
573825002451	Switch II region; other site
573825002452	G4 box; other site
573825002453	G5 box; other site
573825002454	membrane protein; Provisional; Region: PRK14409
573825002455	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
573825002456	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
573825002457	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
573825002458	Walker A/P-loop; other site
573825002459	ATP binding site [chemical binding]; other site
573825002460	Q-loop/lid; other site
573825002461	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
573825002462	ABC transporter signature motif; other site
573825002463	Walker B; other site
573825002464	D-loop; other site
573825002465	H-loop/switch region; other site
573825002466	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825002467	glutamine synthetase, type I; Region: GlnA; TIGR00653
573825002468	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
573825002469	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
573825002470	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
573825002471	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
573825002472	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
573825002473	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
573825002474	dimerization interface [polypeptide binding]; other site
573825002475	ATP binding site [chemical binding]; other site
573825002476	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
573825002477	dimerization interface [polypeptide binding]; other site
573825002478	ATP binding site [chemical binding]; other site
573825002479	Leucine rich repeat; Region: LRR_8; pfam13855
573825002480	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
573825002481	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
573825002482	active site
573825002483	HIGH motif; other site
573825002484	nucleotide binding site [chemical binding]; other site
573825002485	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
573825002486	active site
573825002487	KMSKS motif; other site
573825002488	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
573825002489	tRNA binding surface [nucleotide binding]; other site
573825002490	anticodon binding site; other site
573825002491	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
573825002492	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825002493	anti sigma factor interaction site; other site
573825002494	regulatory phosphorylation site [posttranslational modification]; other site
573825002495	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
573825002496	Predicted amidohydrolase [General function prediction only]; Region: COG0388
573825002497	active site
573825002498	catalytic triad [active]
573825002499	dimer interface [polypeptide binding]; other site
573825002500	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825002501	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002502	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825002503	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002504	amidase; Provisional; Region: PRK06529
573825002505	Amidase; Region: Amidase; pfam01425
573825002506	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
573825002507	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
573825002508	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
573825002509	ABC1 family; Region: ABC1; cl17513
573825002510	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
573825002511	lipoprotein signal peptidase; Provisional; Region: PRK14783
573825002512	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825002513	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825002514	ligand binding site [chemical binding]; other site
573825002515	flexible hinge region; other site
573825002516	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
573825002517	Domain of unknown function DUF20; Region: UPF0118; pfam01594
573825002518	EamA-like transporter family; Region: EamA; pfam00892
573825002519	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
573825002520	EamA-like transporter family; Region: EamA; pfam00892
573825002521	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
573825002522	Sodium Bile acid symporter family; Region: SBF; pfam01758
573825002523	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
573825002524	putative acyl-acceptor binding pocket; other site
573825002525	PGAP1-like protein; Region: PGAP1; pfam07819
573825002526	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825002527	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002528	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002529	active site
573825002530	phosphorylation site [posttranslational modification]
573825002531	intermolecular recognition site; other site
573825002532	dimerization interface [polypeptide binding]; other site
573825002533	CHASE3 domain; Region: CHASE3; pfam05227
573825002534	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825002535	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825002536	dimer interface [polypeptide binding]; other site
573825002537	phosphorylation site [posttranslational modification]
573825002538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825002539	ATP binding site [chemical binding]; other site
573825002540	Mg2+ binding site [ion binding]; other site
573825002541	G-X-G motif; other site
573825002542	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825002543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825002544	S-adenosylmethionine binding site [chemical binding]; other site
573825002545	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
573825002546	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
573825002547	putative active site [active]
573825002548	putative metal binding site [ion binding]; other site
573825002549	Leucine rich repeat; Region: LRR_8; pfam13855
573825002550	leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113
573825002551	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
573825002552	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
573825002553	N-terminal plug; other site
573825002554	ligand-binding site [chemical binding]; other site
573825002555	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
573825002556	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
573825002557	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825002558	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825002559	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
573825002560	hydrophobic ligand binding site; other site
573825002561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825002562	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825002563	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002564	MepB protein; Region: MepB; pfam08877
573825002565	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
573825002566	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
573825002567	Oligomerisation domain; Region: Oligomerisation; pfam02410
573825002568	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825002569	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
573825002570	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825002571	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
573825002572	endonuclease III; Region: ENDO3c; smart00478
573825002573	minor groove reading motif; other site
573825002574	helix-hairpin-helix signature motif; other site
573825002575	substrate binding pocket [chemical binding]; other site
573825002576	active site
573825002577	Major Facilitator Superfamily; Region: MFS_1; pfam07690
573825002578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825002579	Pirin-related protein [General function prediction only]; Region: COG1741
573825002580	Pirin; Region: Pirin; pfam02678
573825002581	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
573825002582	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
573825002583	putative active site [active]
573825002584	catalytic site [active]
573825002585	putative metal binding site [ion binding]; other site
573825002586	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
573825002587	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
573825002588	G1 box; other site
573825002589	putative GEF interaction site [polypeptide binding]; other site
573825002590	GTP/Mg2+ binding site [chemical binding]; other site
573825002591	Switch I region; other site
573825002592	G2 box; other site
573825002593	G3 box; other site
573825002594	Switch II region; other site
573825002595	G4 box; other site
573825002596	G5 box; other site
573825002597	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
573825002598	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
573825002599	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
573825002600	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
573825002601	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
573825002602	conserved cys residue [active]
573825002603	glycyl-tRNA synthetase; Provisional; Region: PRK04173
573825002604	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
573825002605	motif 1; other site
573825002606	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
573825002607	active site
573825002608	motif 2; other site
573825002609	motif 3; other site
573825002610	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
573825002611	anticodon binding site; other site
573825002612	Gram-negative bacterial tonB protein; Region: TonB; cl10048
573825002613	Protease prsW family; Region: PrsW-protease; pfam13367
573825002614	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
573825002615	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
573825002616	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
573825002617	substrate binding site [chemical binding]; other site
573825002618	ATP binding site [chemical binding]; other site
573825002619	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
573825002620	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
573825002621	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
573825002622	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
573825002623	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825002624	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825002625	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
573825002626	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
573825002627	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
573825002628	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
573825002629	dimer interface [polypeptide binding]; other site
573825002630	active site
573825002631	glycine-pyridoxal phosphate binding site [chemical binding]; other site
573825002632	folate binding site [chemical binding]; other site
573825002633	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
573825002634	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
573825002635	putative catalytic site [active]
573825002636	putative metal binding site [ion binding]; other site
573825002637	putative phosphate binding site [ion binding]; other site
573825002638	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
573825002639	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
573825002640	tetramer interface [polypeptide binding]; other site
573825002641	active site
573825002642	Mg2+/Mn2+ binding site [ion binding]; other site
573825002643	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825002644	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
573825002645	dimer interface [polypeptide binding]; other site
573825002646	substrate binding site [chemical binding]; other site
573825002647	metal binding site [ion binding]; metal-binding site
573825002648	GAF domain; Region: GAF_3; pfam13492
573825002649	GAF domain; Region: GAF_2; pfam13185
573825002650	Heme NO binding associated; Region: HNOBA; pfam07701
573825002651	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
573825002652	cyclase homology domain; Region: CHD; cd07302
573825002653	nucleotidyl binding site; other site
573825002654	metal binding site [ion binding]; metal-binding site
573825002655	dimer interface [polypeptide binding]; other site
573825002656	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
573825002657	potential frameshift: common BLAST hit: gi|45658172|ref|YP_002258.1| serine/threonine kinase protein
573825002658	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825002659	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825002660	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825002661	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
573825002662	Catalytic domain of Protein Kinases; Region: PKc; cd00180
573825002663	active site
573825002664	ATP binding site [chemical binding]; other site
573825002665	substrate binding site [chemical binding]; other site
573825002666	activation loop (A-loop); other site
573825002667	AAA ATPase domain; Region: AAA_16; pfam13191
573825002668	Predicted ATPase [General function prediction only]; Region: COG3899
573825002669	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
573825002670	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
573825002671	dimer interface [polypeptide binding]; other site
573825002672	active site
573825002673	CoA binding pocket [chemical binding]; other site
573825002674	Coenzyme A transferase; Region: CoA_trans; pfam01144
573825002675	Coenzyme A transferase; Region: CoA_trans; cl17247
573825002676	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825002677	active site
573825002678	short chain dehydrogenase; Provisional; Region: PRK06172
573825002679	classical (c) SDRs; Region: SDR_c; cd05233
573825002680	NAD(P) binding site [chemical binding]; other site
573825002681	active site
573825002682	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
573825002683	Protein phosphatase 2C; Region: PP2C; pfam00481
573825002684	active site
573825002685	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
573825002686	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
573825002687	active site
573825002688	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002690	active site
573825002691	phosphorylation site [posttranslational modification]
573825002692	intermolecular recognition site; other site
573825002693	dimerization interface [polypeptide binding]; other site
573825002694	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825002695	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825002696	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
573825002697	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
573825002698	nucleotide binding site/active site [active]
573825002699	HIT family signature motif; other site
573825002700	catalytic residue [active]
573825002701	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
573825002702	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
573825002703	nucleotide binding site [chemical binding]; other site
573825002704	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
573825002705	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
573825002706	Walker A/P-loop; other site
573825002707	ATP binding site [chemical binding]; other site
573825002708	Q-loop/lid; other site
573825002709	ABC transporter signature motif; other site
573825002710	Walker B; other site
573825002711	D-loop; other site
573825002712	H-loop/switch region; other site
573825002713	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825002714	binding surface
573825002715	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825002716	TPR motif; other site
573825002717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825002718	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825002719	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002720	Outer membrane efflux protein; Region: OEP; pfam02321
573825002721	Outer membrane efflux protein; Region: OEP; pfam02321
573825002722	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
573825002723	HlyD family secretion protein; Region: HlyD_3; pfam13437
573825002724	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
573825002725	LexA repressor; Validated; Region: PRK00215
573825002726	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
573825002727	Catalytic site [active]
573825002728	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
573825002729	C-terminal peptidase (prc); Region: prc; TIGR00225
573825002730	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
573825002731	protein binding site [polypeptide binding]; other site
573825002732	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
573825002733	Catalytic dyad [active]
573825002734	UGMP family protein; Validated; Region: PRK09604
573825002735	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
573825002736	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
573825002737	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
573825002738	hypothetical protein; Reviewed; Region: PRK00024
573825002739	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
573825002740	MPN+ (JAMM) motif; other site
573825002741	Zinc-binding site [ion binding]; other site
573825002742	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
573825002743	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
573825002744	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
573825002745	Walker A/P-loop; other site
573825002746	ATP binding site [chemical binding]; other site
573825002747	Q-loop/lid; other site
573825002748	ABC transporter signature motif; other site
573825002749	Walker B; other site
573825002750	D-loop; other site
573825002751	H-loop/switch region; other site
573825002752	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
573825002753	putative carbohydrate binding site [chemical binding]; other site
573825002754	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
573825002755	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
573825002756	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
573825002757	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
573825002758	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825002759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825002760	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825002761	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002762	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
573825002763	ATP-grasp domain; Region: ATP-grasp; pfam02222
573825002764	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
573825002765	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
573825002766	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
573825002767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825002768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
573825002769	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
573825002770	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
573825002771	Ca binding site [ion binding]; other site
573825002772	active site
573825002773	catalytic site [active]
573825002774	TRL-like protein family; Region: TRL; pfam13146
573825002775	TRL-like protein family; Region: TRL; pfam13146
573825002776	TRL-like protein family; Region: TRL; pfam13146
573825002777	TPR repeat; Region: TPR_11; pfam13414
573825002778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825002779	binding surface
573825002780	TPR motif; other site
573825002781	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
573825002782	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
573825002783	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825002784	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
573825002785	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
573825002786	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
573825002787	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
573825002788	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
573825002789	motif II; other site
573825002790	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
573825002791	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
573825002792	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
573825002793	catalytic residue [active]
573825002794	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
573825002795	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
573825002796	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
573825002797	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825002798	GAF domain; Region: GAF_3; pfam13492
573825002799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825002800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825002801	metal binding site [ion binding]; metal-binding site
573825002802	active site
573825002803	I-site; other site
573825002804	Aspartyl protease; Region: Asp_protease_2; pfam13650
573825002805	inhibitor binding site; inhibition site
573825002806	catalytic motif [active]
573825002807	Catalytic residue [active]
573825002808	Active site flap [active]
573825002809	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
573825002810	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
573825002811	Ligand Binding Site [chemical binding]; other site
573825002812	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
573825002813	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
573825002814	active site
573825002815	substrate binding site [chemical binding]; other site
573825002816	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
573825002817	FMN binding site [chemical binding]; other site
573825002818	putative catalytic residues [active]
573825002819	PilZ domain; Region: PilZ; pfam07238
573825002820	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
573825002821	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
573825002822	RNA binding surface [nucleotide binding]; other site
573825002823	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
573825002824	active site
573825002825	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
573825002826	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
573825002827	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825002828	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825002829	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
573825002830	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002831	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002832	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002833	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002834	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002835	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825002836	Family description; Region: VCBS; pfam13517
573825002837	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
573825002838	Family description; Region: VCBS; pfam13517
573825002839	FG-GAP repeat; Region: FG-GAP; pfam01839
573825002840	Family description; Region: VCBS; pfam13517
573825002841	FG-GAP repeat; Region: FG-GAP; pfam01839
573825002842	Surface antigen; Region: Bac_surface_Ag; pfam01103
573825002843	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825002844	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825002845	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825002846	Surface antigen; Region: Bac_surface_Ag; pfam01103
573825002847	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825002848	Surface antigen; Region: Bac_surface_Ag; pfam01103
573825002849	L-aspartate oxidase; Provisional; Region: PRK09077
573825002850	L-aspartate oxidase; Provisional; Region: PRK06175
573825002851	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
573825002852	C-terminal peptidase (prc); Region: prc; TIGR00225
573825002853	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
573825002854	protein binding site [polypeptide binding]; other site
573825002855	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
573825002856	Catalytic dyad [active]
573825002857	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
573825002858	active site
573825002859	hydrophilic channel; other site
573825002860	dimerization interface [polypeptide binding]; other site
573825002861	catalytic residues [active]
573825002862	active site lid [active]
573825002863	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
573825002864	TIGR02300 family protein; Region: FYDLN_acid
573825002865	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
573825002866	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
573825002867	bacterial Hfq-like; Region: Hfq; cd01716
573825002868	hexamer interface [polypeptide binding]; other site
573825002869	Sm1 motif; other site
573825002870	RNA binding site [nucleotide binding]; other site
573825002871	Sm2 motif; other site
573825002872	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
573825002873	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
573825002874	Substrate binding site; other site
573825002875	Cupin domain; Region: Cupin_2; cl17218
573825002876	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
573825002877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825002878	binding surface
573825002879	TPR motif; other site
573825002880	FOG: CBS domain [General function prediction only]; Region: COG0517
573825002881	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
573825002882	Response regulator receiver domain; Region: Response_reg; pfam00072
573825002883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825002884	active site
573825002885	phosphorylation site [posttranslational modification]
573825002886	intermolecular recognition site; other site
573825002887	dimerization interface [polypeptide binding]; other site
573825002888	PAS fold; Region: PAS; pfam00989
573825002889	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825002890	putative active site [active]
573825002891	heme pocket [chemical binding]; other site
573825002892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825002893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825002894	dimer interface [polypeptide binding]; other site
573825002895	phosphorylation site [posttranslational modification]
573825002896	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002897	Leucine rich repeat; Region: LRR_8; pfam13855
573825002898	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
573825002899	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
573825002900	putative active site; other site
573825002901	catalytic residue [active]
573825002902	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
573825002903	Thymidylate synthase complementing protein; Region: Thy1; cl03630
573825002904	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
573825002905	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
573825002906	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
573825002907	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
573825002908	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
573825002909	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
573825002910	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
573825002911	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
573825002912	DNA methylase; Region: N6_N4_Mtase; pfam01555
573825002913	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
573825002914	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
573825002915	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
573825002916	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
573825002917	Histidine kinase; Region: HisKA_2; pfam07568
573825002918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825002919	ATP binding site [chemical binding]; other site
573825002920	Mg2+ binding site [ion binding]; other site
573825002921	G-X-G motif; other site
573825002922	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
573825002923	Right handed beta helix region; Region: Beta_helix; pfam13229
573825002924	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
573825002925	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
573825002926	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
573825002927	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
573825002928	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
573825002929	Cu(I) binding site [ion binding]; other site
573825002930	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
573825002931	Protein of unknown function, DUF486; Region: DUF486; cl01236
573825002932	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
573825002933	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
573825002934	putative dimer interface [polypeptide binding]; other site
573825002935	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
573825002936	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
573825002937	putative dimer interface [polypeptide binding]; other site
573825002938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825002939	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825002940	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825002941	potential frameshift: common BLAST hit: gi|45658058|ref|YP_002144.1| lipoprotein
573825002942	Beta-propeller repeat; Region: SBBP; pfam06739
573825002943	Beta-propeller repeat; Region: SBBP; pfam06739
573825002944	Beta-propeller repeat; Region: SBBP; pfam06739
573825002945	Beta-propeller repeat; Region: SBBP; pfam06739
573825002946	Beta-propeller repeat; Region: SBBP; pfam06739
573825002947	Beta-propeller repeat; Region: SBBP; pfam06739
573825002948	Beta-propeller repeat; Region: SBBP; pfam06739
573825002949	Beta-propeller repeat; Region: SBBP; pfam06739
573825002950	Beta-propeller repeat; Region: SBBP; pfam06739
573825002951	Beta-propeller repeat; Region: SBBP; pfam06739
573825002952	Beta-propeller repeat; Region: SBBP; pfam06739
573825002953	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
573825002954	putative DNA binding site [nucleotide binding]; other site
573825002955	putative Zn2+ binding site [ion binding]; other site
573825002956	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
573825002957	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
573825002958	NADP binding site [chemical binding]; other site
573825002959	active site
573825002960	putative substrate binding site [chemical binding]; other site
573825002961	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
573825002962	hydroxyglutarate oxidase; Provisional; Region: PRK11728
573825002963	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
573825002964	dimer interface [polypeptide binding]; other site
573825002965	active site
573825002966	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
573825002967	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
573825002968	NAD binding site [chemical binding]; other site
573825002969	substrate binding site [chemical binding]; other site
573825002970	homodimer interface [polypeptide binding]; other site
573825002971	active site
573825002972	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
573825002973	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
573825002974	active site
573825002975	Substrate binding site; other site
573825002976	Mg++ binding site; other site
573825002977	cytidylyltransferase; Region: cytidylyltransferase; cd02170
573825002978	active site
573825002979	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
573825002980	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
573825002981	putative ribose interaction site [chemical binding]; other site
573825002982	putative ADP binding site [chemical binding]; other site
573825002983	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
573825002984	extended (e) SDRs; Region: SDR_e; cd08946
573825002985	NAD(P) binding site [chemical binding]; other site
573825002986	active site
573825002987	substrate binding site [chemical binding]; other site
573825002988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825002989	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
573825002990	Phosphotransferase enzyme family; Region: APH; pfam01636
573825002991	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
573825002992	transketolase; Reviewed; Region: PRK05899
573825002993	TPP-binding site [chemical binding]; other site
573825002994	dimer interface [polypeptide binding]; other site
573825002995	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
573825002996	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
573825002997	PYR/PP interface [polypeptide binding]; other site
573825002998	dimer interface [polypeptide binding]; other site
573825002999	TPP binding site [chemical binding]; other site
573825003000	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
573825003001	sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324
573825003002	sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323
573825003003	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
573825003004	nudix motif; other site
573825003005	Methyltransferase domain; Region: Methyltransf_31; pfam13847
573825003006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003007	S-adenosylmethionine binding site [chemical binding]; other site
573825003008	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
573825003009	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825003010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003011	S-adenosylmethionine binding site [chemical binding]; other site
573825003012	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
573825003013	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
573825003014	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825003015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003016	S-adenosylmethionine binding site [chemical binding]; other site
573825003017	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
573825003018	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825003019	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825003020	inhibitor-cofactor binding pocket; inhibition site
573825003021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003022	catalytic residue [active]
573825003023	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
573825003024	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
573825003025	active site
573825003026	substrate binding site [chemical binding]; other site
573825003027	cosubstrate binding site; other site
573825003028	catalytic site [active]
573825003029	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
573825003030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825003031	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
573825003032	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
573825003033	putative trimer interface [polypeptide binding]; other site
573825003034	putative CoA binding site [chemical binding]; other site
573825003035	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
573825003036	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825003037	Walker A/P-loop; other site
573825003038	ATP binding site [chemical binding]; other site
573825003039	Q-loop/lid; other site
573825003040	ABC transporter signature motif; other site
573825003041	Walker B; other site
573825003042	D-loop; other site
573825003043	H-loop/switch region; other site
573825003044	WxcM-like, C-terminal; Region: FdtA; pfam05523
573825003045	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825003046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003047	S-adenosylmethionine binding site [chemical binding]; other site
573825003048	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
573825003049	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
573825003050	Ligand binding site; other site
573825003051	Putative Catalytic site; other site
573825003052	DXD motif; other site
573825003053	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
573825003054	ligand binding site; other site
573825003055	tetramer interface; other site
573825003056	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
573825003057	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
573825003058	NAD binding site [chemical binding]; other site
573825003059	substrate binding site [chemical binding]; other site
573825003060	active site
573825003061	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
573825003062	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825003063	inhibitor-cofactor binding pocket; inhibition site
573825003064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003065	catalytic residue [active]
573825003066	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
573825003067	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
573825003068	putative trimer interface [polypeptide binding]; other site
573825003069	putative CoA binding site [chemical binding]; other site
573825003070	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
573825003071	NeuB family; Region: NeuB; pfam03102
573825003072	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
573825003073	NeuB binding interface [polypeptide binding]; other site
573825003074	putative substrate binding site [chemical binding]; other site
573825003075	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
573825003076	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
573825003077	active site
573825003078	homodimer interface [polypeptide binding]; other site
573825003079	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
573825003080	FOG: CBS domain [General function prediction only]; Region: COG0517
573825003081	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
573825003082	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
573825003083	Substrate binding site; other site
573825003084	metal-binding site
573825003085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
573825003086	FOG: CBS domain [General function prediction only]; Region: COG0517
573825003087	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
573825003088	NeuB family; Region: NeuB; pfam03102
573825003089	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
573825003090	NeuB binding interface [polypeptide binding]; other site
573825003091	putative substrate binding site [chemical binding]; other site
573825003092	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
573825003093	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
573825003094	Metal-binding active site; metal-binding site
573825003095	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825003096	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825003097	inhibitor-cofactor binding pocket; inhibition site
573825003098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003099	catalytic residue [active]
573825003100	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
573825003101	ligand binding site; other site
573825003102	tetramer interface; other site
573825003103	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
573825003104	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184
573825003105	putative active site [active]
573825003106	metal binding site [ion binding]; metal-binding site
573825003107	Radical SAM superfamily; Region: Radical_SAM; pfam04055
573825003108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825003109	FeS/SAM binding site; other site
573825003110	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
573825003111	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825003112	Methyltransferase domain; Region: Methyltransf_12; pfam08242
573825003113	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
573825003114	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
573825003115	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
573825003116	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
573825003117	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
573825003118	putative active site [active]
573825003119	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
573825003120	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
573825003121	trimer interface [polypeptide binding]; other site
573825003122	active site
573825003123	substrate binding site [chemical binding]; other site
573825003124	CoA binding site [chemical binding]; other site
573825003125	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
573825003126	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
573825003127	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
573825003128	Ligand binding site; other site
573825003129	oligomer interface; other site
573825003130	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
573825003131	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
573825003132	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
573825003133	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
573825003134	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
573825003135	active site
573825003136	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
573825003137	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
573825003138	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825003139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003140	S-adenosylmethionine binding site [chemical binding]; other site
573825003141	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
573825003142	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
573825003143	putative ligand binding site [chemical binding]; other site
573825003144	putative NAD binding site [chemical binding]; other site
573825003145	catalytic site [active]
573825003146	surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326
573825003147	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
573825003148	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
573825003149	substrate binding site; other site
573825003150	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
573825003151	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
573825003152	NAD binding site [chemical binding]; other site
573825003153	homotetramer interface [polypeptide binding]; other site
573825003154	homodimer interface [polypeptide binding]; other site
573825003155	substrate binding site [chemical binding]; other site
573825003156	active site
573825003157	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
573825003158	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
573825003159	extended (e) SDRs; Region: SDR_e; cd08946
573825003160	NAD(P) binding site [chemical binding]; other site
573825003161	active site
573825003162	substrate binding site [chemical binding]; other site
573825003163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825003164	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
573825003165	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003166	active site
573825003167	Methyltransferase domain; Region: Methyltransf_11; pfam08241
573825003168	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
573825003169	putative active site [active]
573825003170	putative metal binding site [ion binding]; other site
573825003171	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825003172	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
573825003173	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825003174	catalytic residue [active]
573825003175	FemAB family; Region: FemAB; pfam02388
573825003176	Protein of unknown function (DUF1420); Region: DUF1420; pfam07220
573825003177	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825003178	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
573825003179	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
573825003180	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
573825003181	NAD(P) binding site [chemical binding]; other site
573825003182	homodimer interface [polypeptide binding]; other site
573825003183	substrate binding site [chemical binding]; other site
573825003184	active site
573825003185	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
573825003186	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
573825003187	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
573825003188	putative NAD(P) binding site [chemical binding]; other site
573825003189	active site
573825003190	putative substrate binding site [chemical binding]; other site
573825003191	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
573825003192	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
573825003193	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
573825003194	active site
573825003195	homodimer interface [polypeptide binding]; other site
573825003196	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825003197	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
573825003198	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
573825003199	Bacterial sugar transferase; Region: Bac_transf; pfam02397
573825003200	Protein of unknown function (DUF1229); Region: DUF1229; pfam06797
573825003201	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
573825003202	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
573825003203	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003204	active site
573825003205	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
573825003206	WxcM-like, C-terminal; Region: FdtA; pfam05523
573825003207	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
573825003208	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825003209	inhibitor-cofactor binding pocket; inhibition site
573825003210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003211	catalytic residue [active]
573825003212	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
573825003213	metal-binding site
573825003214	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003215	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
573825003216	active site
573825003217	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
573825003218	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
573825003219	Probable Catalytic site; other site
573825003220	metal-binding site
573825003221	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003222	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
573825003223	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
573825003224	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
573825003225	NADP binding site [chemical binding]; other site
573825003226	active site
573825003227	putative substrate binding site [chemical binding]; other site
573825003228	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
573825003229	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
573825003230	NAD binding site [chemical binding]; other site
573825003231	substrate binding site [chemical binding]; other site
573825003232	homodimer interface [polypeptide binding]; other site
573825003233	active site
573825003234	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
573825003235	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
573825003236	substrate binding site; other site
573825003237	tetramer interface; other site
573825003238	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
573825003239	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
573825003240	Probable Catalytic site; other site
573825003241	metal-binding site
573825003242	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
573825003243	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
573825003244	Ligand binding site; other site
573825003245	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
573825003246	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003247	active site
573825003248	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
573825003249	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
573825003250	transmembrane helices; other site
573825003251	HicB family; Region: HicB; pfam05534
573825003252	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
573825003253	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825003254	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825003255	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825003256	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825003257	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
573825003258	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
573825003259	putative active site [active]
573825003260	putative metal binding site [ion binding]; other site
573825003261	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
573825003262	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
573825003263	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
573825003264	dimer interface [polypeptide binding]; other site
573825003265	ssDNA binding site [nucleotide binding]; other site
573825003266	tetramer (dimer of dimers) interface [polypeptide binding]; other site
573825003267	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
573825003268	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
573825003269	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
573825003270	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
573825003271	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
573825003272	replicative DNA helicase; Region: DnaB; TIGR00665
573825003273	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
573825003274	Walker A motif; other site
573825003275	ATP binding site [chemical binding]; other site
573825003276	Walker B motif; other site
573825003277	DNA binding loops [nucleotide binding]
573825003278	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
573825003279	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
573825003280	dimer interface [polypeptide binding]; other site
573825003281	anticodon binding site; other site
573825003282	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
573825003283	homodimer interface [polypeptide binding]; other site
573825003284	motif 1; other site
573825003285	active site
573825003286	motif 2; other site
573825003287	GAD domain; Region: GAD; pfam02938
573825003288	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
573825003289	motif 3; other site
573825003290	PhoH-like protein; Region: PhoH; pfam02562
573825003291	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
573825003292	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
573825003293	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825003294	Zn2+ binding site [ion binding]; other site
573825003295	Mg2+ binding site [ion binding]; other site
573825003296	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
573825003297	Recombination protein O N terminal; Region: RecO_N; pfam11967
573825003298	DNA repair protein RecO; Region: reco; TIGR00613
573825003299	Recombination protein O C terminal; Region: RecO_C; pfam02565
573825003300	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
573825003301	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
573825003302	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
573825003303	active site
573825003304	HIGH motif; other site
573825003305	KMSK motif region; other site
573825003306	DALR anticodon binding domain; Region: DALR_1; smart00836
573825003307	anticodon binding site; other site
573825003308	tRNA binding surface [nucleotide binding]; other site
573825003309	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
573825003310	competence damage-inducible protein A; Provisional; Region: PRK00549
573825003311	putative MPT binding site; other site
573825003312	Competence-damaged protein; Region: CinA; pfam02464
573825003313	Beta-propeller repeat; Region: SBBP; pfam06739
573825003314	Beta-propeller repeat; Region: SBBP; pfam06739
573825003315	Beta-propeller repeat; Region: SBBP; pfam06739
573825003316	Beta-propeller repeat; Region: SBBP; pfam06739
573825003317	Beta-propeller repeat; Region: SBBP; pfam06739
573825003318	Beta-propeller repeat; Region: SBBP; pfam06739
573825003319	Response regulator receiver domain; Region: Response_reg; pfam00072
573825003320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003321	active site
573825003322	phosphorylation site [posttranslational modification]
573825003323	intermolecular recognition site; other site
573825003324	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
573825003325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825003326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825003327	dimer interface [polypeptide binding]; other site
573825003328	phosphorylation site [posttranslational modification]
573825003329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003330	ATP binding site [chemical binding]; other site
573825003331	Mg2+ binding site [ion binding]; other site
573825003332	G-X-G motif; other site
573825003333	triosephosphate isomerase; Provisional; Region: PRK14567
573825003334	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
573825003335	substrate binding site [chemical binding]; other site
573825003336	dimer interface [polypeptide binding]; other site
573825003337	catalytic triad [active]
573825003338	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825003339	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
573825003340	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
573825003341	Phosphoglycerate kinase; Region: PGK; pfam00162
573825003342	substrate binding site [chemical binding]; other site
573825003343	hinge regions; other site
573825003344	ADP binding site [chemical binding]; other site
573825003345	catalytic site [active]
573825003346	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
573825003347	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
573825003348	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
573825003349	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825003350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003351	active site
573825003352	phosphorylation site [posttranslational modification]
573825003353	intermolecular recognition site; other site
573825003354	dimerization interface [polypeptide binding]; other site
573825003355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825003356	dimer interface [polypeptide binding]; other site
573825003357	phosphorylation site [posttranslational modification]
573825003358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003359	ATP binding site [chemical binding]; other site
573825003360	Mg2+ binding site [ion binding]; other site
573825003361	G-X-G motif; other site
573825003362	PAS domain S-box; Region: sensory_box; TIGR00229
573825003363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003364	putative active site [active]
573825003365	heme pocket [chemical binding]; other site
573825003366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003367	putative active site [active]
573825003368	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
573825003369	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
573825003370	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
573825003371	trimer interface [polypeptide binding]; other site
573825003372	putative metal binding site [ion binding]; other site
573825003373	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
573825003374	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
573825003375	dimer interface [polypeptide binding]; other site
573825003376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003377	catalytic residue [active]
573825003378	DNA topoisomerase I; Validated; Region: PRK05582
573825003379	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
573825003380	active site
573825003381	interdomain interaction site; other site
573825003382	putative metal-binding site [ion binding]; other site
573825003383	nucleotide binding site [chemical binding]; other site
573825003384	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
573825003385	domain I; other site
573825003386	DNA binding groove [nucleotide binding]
573825003387	phosphate binding site [ion binding]; other site
573825003388	domain II; other site
573825003389	domain III; other site
573825003390	nucleotide binding site [chemical binding]; other site
573825003391	catalytic site [active]
573825003392	domain IV; other site
573825003393	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
573825003394	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
573825003395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825003396	Walker A/P-loop; other site
573825003397	ATP binding site [chemical binding]; other site
573825003398	Q-loop/lid; other site
573825003399	ABC transporter signature motif; other site
573825003400	Walker B; other site
573825003401	D-loop; other site
573825003402	H-loop/switch region; other site
573825003403	HDOD domain; Region: HDOD; pfam08668
573825003404	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825003405	Zn2+ binding site [ion binding]; other site
573825003406	Mg2+ binding site [ion binding]; other site
573825003407	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
573825003408	tetramerization interface [polypeptide binding]; other site
573825003409	active site
573825003410	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
573825003411	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
573825003412	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825003413	anti sigma factor interaction site; other site
573825003414	regulatory phosphorylation site [posttranslational modification]; other site
573825003415	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
573825003416	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
573825003417	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
573825003418	Transcriptional regulators [Transcription]; Region: MarR; COG1846
573825003419	MarR family; Region: MarR_2; pfam12802
573825003420	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
573825003421	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
573825003422	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
573825003423	putative acyl-acceptor binding pocket; other site
573825003424	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
573825003425	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
573825003426	CheB methylesterase; Region: CheB_methylest; pfam01339
573825003427	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
573825003428	GAF domain; Region: GAF_3; pfam13492
573825003429	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825003430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825003431	dimer interface [polypeptide binding]; other site
573825003432	phosphorylation site [posttranslational modification]
573825003433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003434	ATP binding site [chemical binding]; other site
573825003435	Mg2+ binding site [ion binding]; other site
573825003436	G-X-G motif; other site
573825003437	Response regulator receiver domain; Region: Response_reg; pfam00072
573825003438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003439	active site
573825003440	phosphorylation site [posttranslational modification]
573825003441	intermolecular recognition site; other site
573825003442	dimerization interface [polypeptide binding]; other site
573825003443	Response regulator receiver domain; Region: Response_reg; pfam00072
573825003444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003445	active site
573825003446	phosphorylation site [posttranslational modification]
573825003447	intermolecular recognition site; other site
573825003448	Response regulator receiver domain; Region: Response_reg; pfam00072
573825003449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003450	active site
573825003451	phosphorylation site [posttranslational modification]
573825003452	intermolecular recognition site; other site
573825003453	dimerization interface [polypeptide binding]; other site
573825003454	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825003455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003456	active site
573825003457	phosphorylation site [posttranslational modification]
573825003458	intermolecular recognition site; other site
573825003459	dimerization interface [polypeptide binding]; other site
573825003460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825003461	dimer interface [polypeptide binding]; other site
573825003462	phosphorylation site [posttranslational modification]
573825003463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003464	ATP binding site [chemical binding]; other site
573825003465	Mg2+ binding site [ion binding]; other site
573825003466	G-X-G motif; other site
573825003467	putative transposase OrfB; Reviewed; Region: PHA02517
573825003468	Integrase core domain; Region: rve; pfam00665
573825003469	Integrase core domain; Region: rve_3; cl15866
573825003470	putative transposase OrfB; Reviewed; Region: PHA02517
573825003471	Integrase core domain; Region: rve; pfam00665
573825003472	Integrase core domain; Region: rve_3; pfam13683
573825003473	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
573825003474	kelch-like protein; Provisional; Region: PHA03098
573825003475	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
573825003476	Family description; Region: VCBS; pfam13517
573825003477	Family description; Region: VCBS; pfam13517
573825003478	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
573825003479	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
573825003480	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
573825003481	RHS Repeat; Region: RHS_repeat; pfam05593
573825003482	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
573825003483	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
573825003484	Integrase core domain; Region: rve; pfam00665
573825003485	Integrase core domain; Region: rve_3; pfam13683
573825003486	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825003487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825003488	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
573825003489	PemK-like protein; Region: PemK; cl00995
573825003490	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
573825003491	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825003492	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
573825003493	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
573825003494	PIN domain; Region: PIN; pfam01850
573825003495	putative active site [active]
573825003496	Protein of unknown function DUF86; Region: DUF86; cl01031
573825003497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825003498	Coenzyme A binding pocket [chemical binding]; other site
573825003499	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
573825003500	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825003501	putative transposase OrfB; Reviewed; Region: PHA02517
573825003502	Integrase core domain; Region: rve; pfam00665
573825003503	Integrase core domain; Region: rve_3; pfam13683
573825003504	L-ascorbate oxidase; Region: PLN02191
573825003505	ribbon-helix-helix domain containing protein; Region: PHA00617
573825003506	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
573825003507	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825003508	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825003509	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
573825003510	trimer interface [polypeptide binding]; other site
573825003511	active site
573825003512	substrate binding site [chemical binding]; other site
573825003513	CoA binding site [chemical binding]; other site
573825003514	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
573825003515	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
573825003516	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825003517	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825003518	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
573825003519	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
573825003520	Helix-turn-helix domain; Region: HTH_36; pfam13730
573825003521	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
573825003522	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
573825003523	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825003524	Magnesium ion binding site [ion binding]; other site
573825003525	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
573825003526	ParB-like nuclease domain; Region: ParB; smart00470
573825003527	Helix-turn-helix domain; Region: HTH_36; pfam13730
573825003528	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
573825003529	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
573825003530	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
573825003531	dimer interface [polypeptide binding]; other site
573825003532	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825003533	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
573825003534	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
573825003535	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
573825003536	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
573825003537	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
573825003538	metal binding site 2 [ion binding]; metal-binding site
573825003539	putative DNA binding helix; other site
573825003540	metal binding site 1 [ion binding]; metal-binding site
573825003541	structural Zn2+ binding site [ion binding]; other site
573825003542	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825003543	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825003544	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
573825003545	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
573825003546	tetramer interface [polypeptide binding]; other site
573825003547	heme binding pocket [chemical binding]; other site
573825003548	NADPH binding site [chemical binding]; other site
573825003549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003550	PAS fold; Region: PAS_3; pfam08447
573825003551	putative active site [active]
573825003552	heme pocket [chemical binding]; other site
573825003553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003554	PAS fold; Region: PAS_3; pfam08447
573825003555	putative active site [active]
573825003556	heme pocket [chemical binding]; other site
573825003557	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003558	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
573825003559	putative active site [active]
573825003560	heme pocket [chemical binding]; other site
573825003561	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825003562	putative active site [active]
573825003563	heme pocket [chemical binding]; other site
573825003564	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825003565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003566	ATP binding site [chemical binding]; other site
573825003567	Mg2+ binding site [ion binding]; other site
573825003568	G-X-G motif; other site
573825003569	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825003570	PGAP1-like protein; Region: PGAP1; pfam07819
573825003571	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
573825003572	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
573825003573	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
573825003574	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
573825003575	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
573825003576	active site
573825003577	HIGH motif; other site
573825003578	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
573825003579	KMSKS motif; other site
573825003580	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
573825003581	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
573825003582	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
573825003583	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14177
573825003584	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
573825003585	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
573825003586	homodimer interface [polypeptide binding]; other site
573825003587	NADP binding site [chemical binding]; other site
573825003588	substrate binding site [chemical binding]; other site
573825003589	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
573825003590	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
573825003591	putative dimer interface [polypeptide binding]; other site
573825003592	putative anticodon binding site; other site
573825003593	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
573825003594	homodimer interface [polypeptide binding]; other site
573825003595	motif 1; other site
573825003596	motif 2; other site
573825003597	active site
573825003598	motif 3; other site
573825003599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825003600	TPR motif; other site
573825003601	binding surface
573825003602	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
573825003603	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825003604	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
573825003605	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
573825003606	DEAD_2; Region: DEAD_2; pfam06733
573825003607	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
573825003608	Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333
573825003609	Na2 binding site [ion binding]; other site
573825003610	substrate binding site 1 [chemical binding]; other site
573825003611	Na binding site 1 [ion binding]; other site
573825003612	substrate binding site 2 [chemical binding]; other site
573825003613	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
573825003614	Clp amino terminal domain; Region: Clp_N; pfam02861
573825003615	Clp amino terminal domain; Region: Clp_N; pfam02861
573825003616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825003617	Walker A motif; other site
573825003618	ATP binding site [chemical binding]; other site
573825003619	Walker B motif; other site
573825003620	arginine finger; other site
573825003621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825003622	Walker A motif; other site
573825003623	ATP binding site [chemical binding]; other site
573825003624	Walker B motif; other site
573825003625	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
573825003626	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
573825003627	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825003628	salt bridge; other site
573825003629	non-specific DNA binding site [nucleotide binding]; other site
573825003630	sequence-specific DNA binding site [nucleotide binding]; other site
573825003631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825003632	non-specific DNA binding site [nucleotide binding]; other site
573825003633	salt bridge; other site
573825003634	sequence-specific DNA binding site [nucleotide binding]; other site
573825003635	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825003636	anti sigma factor interaction site; other site
573825003637	regulatory phosphorylation site [posttranslational modification]; other site
573825003638	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
573825003639	GTP-binding protein LepA; Provisional; Region: PRK05433
573825003640	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
573825003641	G1 box; other site
573825003642	putative GEF interaction site [polypeptide binding]; other site
573825003643	GTP/Mg2+ binding site [chemical binding]; other site
573825003644	Switch I region; other site
573825003645	G2 box; other site
573825003646	G3 box; other site
573825003647	Switch II region; other site
573825003648	G4 box; other site
573825003649	G5 box; other site
573825003650	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
573825003651	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
573825003652	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
573825003653	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
573825003654	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
573825003655	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
573825003656	putative trimer interface [polypeptide binding]; other site
573825003657	putative CoA binding site [chemical binding]; other site
573825003658	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
573825003659	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
573825003660	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
573825003661	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
573825003662	L-aspartate oxidase; Provisional; Region: PRK06175
573825003663	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
573825003664	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
573825003665	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
573825003666	putative Iron-sulfur protein interface [polypeptide binding]; other site
573825003667	proximal heme binding site [chemical binding]; other site
573825003668	distal heme binding site [chemical binding]; other site
573825003669	putative dimer interface [polypeptide binding]; other site
573825003670	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
573825003671	active site
573825003672	catalytic tetrad [active]
573825003673	Domain of unknown function (DUF309); Region: DUF309; pfam03745
573825003674	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
573825003675	CoenzymeA binding site [chemical binding]; other site
573825003676	subunit interaction site [polypeptide binding]; other site
573825003677	PHB binding site; other site
573825003678	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
573825003679	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
573825003680	ligand binding site [chemical binding]; other site
573825003681	NAD binding site [chemical binding]; other site
573825003682	tetramer interface [polypeptide binding]; other site
573825003683	catalytic site [active]
573825003684	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
573825003685	L-serine binding site [chemical binding]; other site
573825003686	ACT domain interface; other site
573825003687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825003688	binding surface
573825003689	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825003690	TPR motif; other site
573825003691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825003692	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825003693	binding surface
573825003694	TPR motif; other site
573825003695	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
573825003696	glycogen binding site [chemical binding]; other site
573825003697	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
573825003698	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
573825003699	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
573825003700	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
573825003701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
573825003702	MORN repeat; Region: MORN; cl14787
573825003703	MORN repeat; Region: MORN; cl14787
573825003704	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825003705	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
573825003706	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
573825003707	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
573825003708	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825003709	catalytic residues [active]
573825003710	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
573825003711	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825003712	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825003713	ligand binding site [chemical binding]; other site
573825003714	flexible hinge region; other site
573825003715	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825003716	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825003717	ligand binding site [chemical binding]; other site
573825003718	flexible hinge region; other site
573825003719	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825003720	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825003721	active site
573825003722	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
573825003723	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
573825003724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825003725	Major Facilitator Superfamily; Region: MFS_1; pfam07690
573825003726	putative substrate translocation pore; other site
573825003727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825003728	major vault protein; Provisional; Region: PTZ00491
573825003729	Bifunctional nuclease; Region: DNase-RNase; pfam02577
573825003730	UvrB/uvrC motif; Region: UVR; pfam02151
573825003731	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
573825003732	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825003733	putative transposase OrfB; Reviewed; Region: PHA02517
573825003734	Integrase core domain; Region: rve; pfam00665
573825003735	Integrase core domain; Region: rve_3; pfam13683
573825003736	Transposase; Region: HTH_Tnp_1; cl17663
573825003737	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
573825003738	HEAT repeats; Region: HEAT_2; pfam13646
573825003739	HEAT repeats; Region: HEAT_2; pfam13646
573825003740	HEAT repeats; Region: HEAT_2; pfam13646
573825003741	Response regulator receiver domain; Region: Response_reg; pfam00072
573825003742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003743	active site
573825003744	phosphorylation site [posttranslational modification]
573825003745	intermolecular recognition site; other site
573825003746	dimerization interface [polypeptide binding]; other site
573825003747	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
573825003748	enolase; Provisional; Region: eno; PRK00077
573825003749	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
573825003750	dimer interface [polypeptide binding]; other site
573825003751	metal binding site [ion binding]; metal-binding site
573825003752	substrate binding pocket [chemical binding]; other site
573825003753	Septum formation initiator; Region: DivIC; pfam04977
573825003754	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
573825003755	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
573825003756	oligomer interface [polypeptide binding]; other site
573825003757	active site residues [active]
573825003758	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
573825003759	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
573825003760	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
573825003761	catalytic residues [active]
573825003762	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
573825003763	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
573825003764	catalytic triad [active]
573825003765	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
573825003766	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
573825003767	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
573825003768	nucleotide binding region [chemical binding]; other site
573825003769	Outer membrane efflux protein; Region: OEP; pfam02321
573825003770	Outer membrane efflux protein; Region: OEP; pfam02321
573825003771	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
573825003772	HlyD family secretion protein; Region: HlyD_3; pfam13437
573825003773	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
573825003774	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
573825003775	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
573825003776	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
573825003777	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
573825003778	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
573825003779	active site
573825003780	NTP binding site [chemical binding]; other site
573825003781	metal binding triad [ion binding]; metal-binding site
573825003782	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
573825003783	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
573825003784	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
573825003785	RNA/DNA hybrid binding site [nucleotide binding]; other site
573825003786	active site
573825003787	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
573825003788	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
573825003789	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
573825003790	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
573825003791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825003792	NAD(P) binding site [chemical binding]; other site
573825003793	active site
573825003794	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
573825003795	FAD binding domain; Region: FAD_binding_4; pfam01565
573825003796	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
573825003797	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
573825003798	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
573825003799	Ligand binding site; other site
573825003800	Putative Catalytic site; other site
573825003801	DXD motif; other site
573825003802	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825003803	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
573825003804	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
573825003805	inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314
573825003806	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
573825003807	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
573825003808	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
573825003809	active site
573825003810	RNA methyltransferase, RsmE family; Region: TIGR00046
573825003811	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
573825003812	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
573825003813	thiamine phosphate binding site [chemical binding]; other site
573825003814	active site
573825003815	pyrophosphate binding site [ion binding]; other site
573825003816	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
573825003817	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
573825003818	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
573825003819	dimer interface [polypeptide binding]; other site
573825003820	putative anticodon binding site; other site
573825003821	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
573825003822	motif 1; other site
573825003823	active site
573825003824	motif 2; other site
573825003825	motif 3; other site
573825003826	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825003827	active site
573825003828	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
573825003829	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
573825003830	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
573825003831	putative active site [active]
573825003832	putative metal binding site [ion binding]; other site
573825003833	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
573825003834	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
573825003835	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825003836	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
573825003837	FliG C-terminal domain; Region: FliG_C; pfam01706
573825003838	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
573825003839	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
573825003840	E3 interaction surface; other site
573825003841	lipoyl attachment site [posttranslational modification]; other site
573825003842	e3 binding domain; Region: E3_binding; pfam02817
573825003843	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
573825003844	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
573825003845	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
573825003846	alpha subunit interface [polypeptide binding]; other site
573825003847	TPP binding site [chemical binding]; other site
573825003848	heterodimer interface [polypeptide binding]; other site
573825003849	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
573825003850	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
573825003851	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
573825003852	tetramer interface [polypeptide binding]; other site
573825003853	TPP-binding site [chemical binding]; other site
573825003854	heterodimer interface [polypeptide binding]; other site
573825003855	phosphorylation loop region [posttranslational modification]
573825003856	DNA-binding response regulator CreB; Provisional; Region: PRK11083
573825003857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825003858	active site
573825003859	phosphorylation site [posttranslational modification]
573825003860	intermolecular recognition site; other site
573825003861	dimerization interface [polypeptide binding]; other site
573825003862	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
573825003863	DNA binding site [nucleotide binding]
573825003864	sensory histidine kinase CreC; Provisional; Region: PRK11100
573825003865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825003866	ATP binding site [chemical binding]; other site
573825003867	Mg2+ binding site [ion binding]; other site
573825003868	G-X-G motif; other site
573825003869	inner membrane protein; Provisional; Region: PRK11715
573825003870	flagellin; Provisional; Region: PRK12804
573825003871	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
573825003872	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
573825003873	flagellin; Provisional; Region: PRK12804
573825003874	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
573825003875	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
573825003876	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
573825003877	Cytochrome c; Region: Cytochrom_C; cl11414
573825003878	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
573825003879	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
573825003880	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
573825003881	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
573825003882	Peptidase family M48; Region: Peptidase_M48; cl12018
573825003883	TIGR02453 family protein; Region: TIGR02453
573825003884	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825003885	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
573825003886	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
573825003887	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
573825003888	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
573825003889	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
573825003890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003891	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
573825003892	nucleotide binding site/active site [active]
573825003893	HIT family signature motif; other site
573825003894	catalytic residue [active]
573825003895	MraW methylase family; Region: Methyltransf_5; cl17771
573825003896	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
573825003897	Cell division protein FtsL; Region: FtsL; cl11433
573825003898	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
573825003899	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825003900	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
573825003901	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
573825003902	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
573825003903	Mg++ binding site [ion binding]; other site
573825003904	putative catalytic motif [active]
573825003905	putative substrate binding site [chemical binding]; other site
573825003906	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
573825003907	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
573825003908	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
573825003909	active site
573825003910	homodimer interface [polypeptide binding]; other site
573825003911	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
573825003912	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
573825003913	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825003914	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
573825003915	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
573825003916	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
573825003917	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
573825003918	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
573825003919	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
573825003920	mce related protein; Region: MCE; pfam02470
573825003921	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
573825003922	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
573825003923	Walker A/P-loop; other site
573825003924	ATP binding site [chemical binding]; other site
573825003925	Q-loop/lid; other site
573825003926	ABC transporter signature motif; other site
573825003927	Walker B; other site
573825003928	D-loop; other site
573825003929	H-loop/switch region; other site
573825003930	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
573825003931	Permease; Region: Permease; pfam02405
573825003932	D-alanyl-alanine synthetase A; Provisional; Region: PRK14572
573825003933	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
573825003934	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825003935	Methyltransferase domain; Region: Methyltransf_31; pfam13847
573825003936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825003937	S-adenosylmethionine binding site [chemical binding]; other site
573825003938	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
573825003939	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
573825003940	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
573825003941	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
573825003942	homodimer interface [polypeptide binding]; other site
573825003943	substrate-cofactor binding pocket; other site
573825003944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825003945	catalytic residue [active]
573825003946	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
573825003947	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
573825003948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825003949	Walker A motif; other site
573825003950	ATP binding site [chemical binding]; other site
573825003951	Walker B motif; other site
573825003952	arginine finger; other site
573825003953	flagellar motor switch protein FliN; Region: fliN; TIGR02480
573825003954	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
573825003955	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
573825003956	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
573825003957	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
573825003958	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
573825003959	Haem-binding domain; Region: Haem_bd; pfam14376
573825003960	argininosuccinate lyase; Provisional; Region: PRK00855
573825003961	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
573825003962	active sites [active]
573825003963	tetramer interface [polypeptide binding]; other site
573825003964	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
573825003965	active site
573825003966	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
573825003967	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
573825003968	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
573825003969	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
573825003970	FecR protein; Region: FecR; pfam04773
573825003971	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
573825003972	Uncharacterized conserved protein [Function unknown]; Region: COG4095
573825003973	7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139
573825003974	GMP synthase; Reviewed; Region: guaA; PRK00074
573825003975	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
573825003976	AMP/PPi binding site [chemical binding]; other site
573825003977	candidate oxyanion hole; other site
573825003978	catalytic triad [active]
573825003979	potential glutamine specificity residues [chemical binding]; other site
573825003980	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
573825003981	ATP Binding subdomain [chemical binding]; other site
573825003982	Ligand Binding sites [chemical binding]; other site
573825003983	Dimerization subdomain; other site
573825003984	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
573825003985	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
573825003986	O-Antigen ligase; Region: Wzy_C; pfam04932
573825003987	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
573825003988	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
573825003989	putative metal binding site; other site
573825003990	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
573825003991	dimer interface [polypeptide binding]; other site
573825003992	active site
573825003993	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
573825003994	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
573825003995	Walker A/P-loop; other site
573825003996	ATP binding site [chemical binding]; other site
573825003997	Q-loop/lid; other site
573825003998	ABC transporter signature motif; other site
573825003999	Walker B; other site
573825004000	D-loop; other site
573825004001	H-loop/switch region; other site
573825004002	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
573825004003	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
573825004004	phosphopeptide binding site; other site
573825004005	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
573825004006	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
573825004007	substrate binding site [chemical binding]; other site
573825004008	ligand binding site [chemical binding]; other site
573825004009	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
573825004010	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
573825004011	substrate binding site [chemical binding]; other site
573825004012	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
573825004013	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
573825004014	dimer interface [polypeptide binding]; other site
573825004015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825004016	catalytic residue [active]
573825004017	AAA domain; Region: AAA_11; pfam13086
573825004018	Part of AAA domain; Region: AAA_19; pfam13245
573825004019	AAA domain; Region: AAA_12; pfam13087
573825004020	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825004021	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825004022	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825004023	DNA binding residues [nucleotide binding]
573825004024	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
573825004025	Protein of unknown function, DUF482; Region: DUF482; pfam04339
573825004026	Uncharacterized conserved protein [Function unknown]; Region: COG2127
573825004027	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
573825004028	Clp amino terminal domain; Region: Clp_N; pfam02861
573825004029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004030	Walker A motif; other site
573825004031	ATP binding site [chemical binding]; other site
573825004032	Walker B motif; other site
573825004033	arginine finger; other site
573825004034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004035	Walker A motif; other site
573825004036	ATP binding site [chemical binding]; other site
573825004037	Walker B motif; other site
573825004038	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
573825004039	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
573825004040	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
573825004041	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
573825004042	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
573825004043	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825004044	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825004045	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
573825004046	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
573825004047	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
573825004048	putative GSH binding site [chemical binding]; other site
573825004049	catalytic residues [active]
573825004050	BolA-like protein; Region: BolA; pfam01722
573825004051	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
573825004052	inner membrane transport permease; Provisional; Region: PRK15066
573825004053	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825004054	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
573825004055	Walker A/P-loop; other site
573825004056	ATP binding site [chemical binding]; other site
573825004057	Q-loop/lid; other site
573825004058	ABC transporter signature motif; other site
573825004059	Walker B; other site
573825004060	D-loop; other site
573825004061	H-loop/switch region; other site
573825004062	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
573825004063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
573825004064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825004065	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
573825004066	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
573825004067	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825004068	anti sigma factor interaction site; other site
573825004069	regulatory phosphorylation site [posttranslational modification]; other site
573825004070	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
573825004071	glycerol kinase; Provisional; Region: glpK; PRK00047
573825004072	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
573825004073	N- and C-terminal domain interface [polypeptide binding]; other site
573825004074	active site
573825004075	MgATP binding site [chemical binding]; other site
573825004076	catalytic site [active]
573825004077	metal binding site [ion binding]; metal-binding site
573825004078	glycerol binding site [chemical binding]; other site
573825004079	homotetramer interface [polypeptide binding]; other site
573825004080	homodimer interface [polypeptide binding]; other site
573825004081	FBP binding site [chemical binding]; other site
573825004082	protein IIAGlc interface [polypeptide binding]; other site
573825004083	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
573825004084	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825004085	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825004086	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
573825004087	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
573825004088	tandem repeat interface [polypeptide binding]; other site
573825004089	oligomer interface [polypeptide binding]; other site
573825004090	active site residues [active]
573825004091	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
573825004092	active site
573825004093	catalytic residues [active]
573825004094	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
573825004095	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
573825004096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
573825004097	ATP binding site [chemical binding]; other site
573825004098	putative Mg++ binding site [ion binding]; other site
573825004099	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825004100	nucleotide binding region [chemical binding]; other site
573825004101	ATP-binding site [chemical binding]; other site
573825004102	aspartate aminotransferase; Provisional; Region: PRK05764
573825004103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825004104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825004105	homodimer interface [polypeptide binding]; other site
573825004106	catalytic residue [active]
573825004107	PGAP1-like protein; Region: PGAP1; pfam07819
573825004108	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825004109	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
573825004110	Na binding site [ion binding]; other site
573825004111	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
573825004112	Thioredoxin; Region: Thioredoxin_4; pfam13462
573825004113	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
573825004114	malate dehydrogenase; Provisional; Region: PRK05442
573825004115	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
573825004116	NAD(P) binding site [chemical binding]; other site
573825004117	dimer interface [polypeptide binding]; other site
573825004118	malate binding site [chemical binding]; other site
573825004119	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
573825004120	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
573825004121	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825004122	catalytic residue [active]
573825004123	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
573825004124	AAA domain; Region: AAA_26; pfam13500
573825004125	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
573825004126	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
573825004127	inhibitor-cofactor binding pocket; inhibition site
573825004128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825004129	catalytic residue [active]
573825004130	biotin synthase; Region: bioB; TIGR00433
573825004131	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825004132	FeS/SAM binding site; other site
573825004133	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
573825004134	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
573825004135	active site
573825004136	catalytic triad [active]
573825004137	oxyanion hole [active]
573825004138	phosphoserine phosphatase SerB; Region: serB; TIGR00338
573825004139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
573825004140	motif II; other site
573825004141	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
573825004142	MutS domain I; Region: MutS_I; pfam01624
573825004143	MutS domain II; Region: MutS_II; pfam05188
573825004144	MutS domain III; Region: MutS_III; pfam05192
573825004145	MutS domain V; Region: MutS_V; pfam00488
573825004146	Walker A/P-loop; other site
573825004147	ATP binding site [chemical binding]; other site
573825004148	Q-loop/lid; other site
573825004149	ABC transporter signature motif; other site
573825004150	Walker B; other site
573825004151	D-loop; other site
573825004152	H-loop/switch region; other site
573825004153	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
573825004154	active site
573825004155	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
573825004156	Response regulator receiver domain; Region: Response_reg; pfam00072
573825004157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004158	active site
573825004159	phosphorylation site [posttranslational modification]
573825004160	intermolecular recognition site; other site
573825004161	dimerization interface [polypeptide binding]; other site
573825004162	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
573825004163	tartrate dehydrogenase; Region: TTC; TIGR02089
573825004164	acetylornithine aminotransferase; Provisional; Region: PRK02627
573825004165	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
573825004166	inhibitor-cofactor binding pocket; inhibition site
573825004167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825004168	catalytic residue [active]
573825004169	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
573825004170	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
573825004171	active site
573825004172	substrate binding site [chemical binding]; other site
573825004173	metal binding site [ion binding]; metal-binding site
573825004174	transaminase; Validated; Region: PRK07324
573825004175	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825004176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825004177	homodimer interface [polypeptide binding]; other site
573825004178	catalytic residue [active]
573825004179	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
573825004180	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
573825004181	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
573825004182	minor groove reading motif; other site
573825004183	helix-hairpin-helix signature motif; other site
573825004184	substrate binding pocket [chemical binding]; other site
573825004185	active site
573825004186	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
573825004187	RF-1 domain; Region: RF-1; pfam00472
573825004188	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
573825004189	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
573825004190	GIY-YIG motif/motif A; other site
573825004191	active site
573825004192	catalytic site [active]
573825004193	putative DNA binding site [nucleotide binding]; other site
573825004194	metal binding site [ion binding]; metal-binding site
573825004195	UvrB/uvrC motif; Region: UVR; pfam02151
573825004196	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
573825004197	Helix-hairpin-helix motif; Region: HHH; pfam00633
573825004198	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
573825004199	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
573825004200	putative active site [active]
573825004201	catalytic site [active]
573825004202	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
573825004203	putative active site [active]
573825004204	catalytic site [active]
573825004205	O-Antigen ligase; Region: Wzy_C; pfam04932
573825004206	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825004207	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
573825004208	putative ADP-binding pocket [chemical binding]; other site
573825004209	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
573825004210	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
573825004211	putative active site [active]
573825004212	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
573825004213	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825004214	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825004215	ligand binding site [chemical binding]; other site
573825004216	flexible hinge region; other site
573825004217	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
573825004218	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
573825004219	nucleophile elbow; other site
573825004220	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
573825004221	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
573825004222	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
573825004223	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
573825004224	acyl-activating enzyme (AAE) consensus motif; other site
573825004225	putative AMP binding site [chemical binding]; other site
573825004226	putative active site [active]
573825004227	putative CoA binding site [chemical binding]; other site
573825004228	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
573825004229	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
573825004230	recombinase A; Provisional; Region: recA; PRK09354
573825004231	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
573825004232	hexamer interface [polypeptide binding]; other site
573825004233	Walker A motif; other site
573825004234	ATP binding site [chemical binding]; other site
573825004235	Walker B motif; other site
573825004236	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
573825004237	nucleotide binding site/active site [active]
573825004238	HIT family signature motif; other site
573825004239	catalytic residue [active]
573825004240	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
573825004241	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
573825004242	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
573825004243	MG2 domain; Region: A2M_N; pfam01835
573825004244	Alpha-2-macroglobulin family; Region: A2M; pfam00207
573825004245	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
573825004246	Transglycosylase; Region: Transgly; pfam00912
573825004247	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
573825004248	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
573825004249	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004250	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
573825004251	Walker A motif; other site
573825004252	ATP binding site [chemical binding]; other site
573825004253	Walker B motif; other site
573825004254	arginine finger; other site
573825004255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
573825004256	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
573825004257	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
573825004258	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
573825004259	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
573825004260	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
573825004261	Part of AAA domain; Region: AAA_19; pfam13245
573825004262	Family description; Region: UvrD_C_2; pfam13538
573825004263	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
573825004264	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
573825004265	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825004266	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825004267	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
573825004268	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
573825004269	active site
573825004270	FMN binding site [chemical binding]; other site
573825004271	2,4-decadienoyl-CoA binding site; other site
573825004272	catalytic residue [active]
573825004273	4Fe-4S cluster binding site [ion binding]; other site
573825004274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825004275	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
573825004276	amidase catalytic site [active]
573825004277	Zn binding residues [ion binding]; other site
573825004278	substrate binding site [chemical binding]; other site
573825004279	2-isopropylmalate synthase; Validated; Region: PRK00915
573825004280	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
573825004281	active site
573825004282	catalytic residues [active]
573825004283	metal binding site [ion binding]; metal-binding site
573825004284	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
573825004285	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
573825004286	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
573825004287	active site
573825004288	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
573825004289	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
573825004290	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
573825004291	active site
573825004292	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
573825004293	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
573825004294	tandem repeat interface [polypeptide binding]; other site
573825004295	oligomer interface [polypeptide binding]; other site
573825004296	active site residues [active]
573825004297	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
573825004298	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
573825004299	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
573825004300	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
573825004301	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825004302	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
573825004303	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
573825004304	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825004305	ligand binding site [chemical binding]; other site
573825004306	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
573825004307	MgtE intracellular N domain; Region: MgtE_N; pfam03448
573825004308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
573825004309	Divalent cation transporter; Region: MgtE; pfam01769
573825004310	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
573825004311	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
573825004312	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
573825004313	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
573825004314	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
573825004315	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
573825004316	Soluble P-type ATPase [General function prediction only]; Region: COG4087
573825004317	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
573825004318	PAS domain; Region: PAS; smart00091
573825004319	PAS fold; Region: PAS_4; pfam08448
573825004320	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825004321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825004322	dimer interface [polypeptide binding]; other site
573825004323	phosphorylation site [posttranslational modification]
573825004324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004325	ATP binding site [chemical binding]; other site
573825004326	Mg2+ binding site [ion binding]; other site
573825004327	G-X-G motif; other site
573825004328	Response regulator receiver domain; Region: Response_reg; pfam00072
573825004329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004330	active site
573825004331	phosphorylation site [posttranslational modification]
573825004332	intermolecular recognition site; other site
573825004333	dimerization interface [polypeptide binding]; other site
573825004334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825004335	dimer interface [polypeptide binding]; other site
573825004336	phosphorylation site [posttranslational modification]
573825004337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004338	ATP binding site [chemical binding]; other site
573825004339	Mg2+ binding site [ion binding]; other site
573825004340	G-X-G motif; other site
573825004341	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825004342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004343	active site
573825004344	phosphorylation site [posttranslational modification]
573825004345	intermolecular recognition site; other site
573825004346	dimerization interface [polypeptide binding]; other site
573825004347	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825004348	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825004349	dimer interface [polypeptide binding]; other site
573825004350	phosphorylation site [posttranslational modification]
573825004351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004352	ATP binding site [chemical binding]; other site
573825004353	G-X-G motif; other site
573825004354	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
573825004355	AMP binding site [chemical binding]; other site
573825004356	metal binding site [ion binding]; metal-binding site
573825004357	active site
573825004358	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
573825004359	Yqey-like protein; Region: YqeY; pfam09424
573825004360	CHC2 zinc finger; Region: zf-CHC2; pfam01807
573825004361	DNA primase; Validated; Region: dnaG; PRK05667
573825004362	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
573825004363	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
573825004364	active site
573825004365	metal binding site [ion binding]; metal-binding site
573825004366	interdomain interaction site; other site
573825004367	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
573825004368	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
573825004369	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
573825004370	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825004371	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
573825004372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825004373	DNA binding residues [nucleotide binding]
573825004374	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
573825004375	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
573825004376	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
573825004377	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
573825004378	active site
573825004379	HIGH motif; other site
573825004380	dimer interface [polypeptide binding]; other site
573825004381	KMSKS motif; other site
573825004382	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
573825004383	RNA binding surface [nucleotide binding]; other site
573825004384	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
573825004385	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
573825004386	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
573825004387	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825004388	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
573825004389	hydrophobic ligand binding site; other site
573825004390	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825004391	dimer interface [polypeptide binding]; other site
573825004392	putative CheW interface [polypeptide binding]; other site
573825004393	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
573825004394	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
573825004395	active site
573825004396	Zn binding site [ion binding]; other site
573825004397	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
573825004398	active site
573825004399	DJ-1 family protein; Region: not_thiJ; TIGR01383
573825004400	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
573825004401	conserved cys residue [active]
573825004402	NAD-dependent deacetylase; Provisional; Region: PRK00481
573825004403	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
573825004404	NAD+ binding site [chemical binding]; other site
573825004405	substrate binding site [chemical binding]; other site
573825004406	Zn binding site [ion binding]; other site
573825004407	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825004408	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
573825004409	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825004410	YacP-like NYN domain; Region: NYN_YacP; pfam05991
573825004411	Protein of unknown function (DUF962); Region: DUF962; cl01879
573825004412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825004413	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825004414	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
573825004415	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
573825004416	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
573825004417	FAD binding domain; Region: FAD_binding_4; pfam01565
573825004418	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825004419	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825004420	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825004421	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825004422	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825004423	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
573825004424	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
573825004425	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825004426	substrate binding site [chemical binding]; other site
573825004427	oxyanion hole (OAH) forming residues; other site
573825004428	trimer interface [polypeptide binding]; other site
573825004429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825004430	binding surface
573825004431	TPR motif; other site
573825004432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825004433	TPR motif; other site
573825004434	binding surface
573825004435	TPR repeat; Region: TPR_11; pfam13414
573825004436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825004437	binding surface
573825004438	TPR motif; other site
573825004439	TPR repeat; Region: TPR_11; pfam13414
573825004440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825004441	binding surface
573825004442	TPR motif; other site
573825004443	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825004444	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
573825004445	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
573825004446	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825004447	catalytic residue [active]
573825004448	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
573825004449	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825004450	Zn2+ binding site [ion binding]; other site
573825004451	Mg2+ binding site [ion binding]; other site
573825004452	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
573825004453	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
573825004454	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
573825004455	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
573825004456	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
573825004457	active site
573825004458	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
573825004459	HSP70 interaction site [polypeptide binding]; other site
573825004460	Flagellar protein FliS; Region: FliS; cl00654
573825004461	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
573825004462	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
573825004463	active site
573825004464	substrate binding site [chemical binding]; other site
573825004465	cosubstrate binding site; other site
573825004466	catalytic site [active]
573825004467	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
573825004468	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
573825004469	purine monophosphate binding site [chemical binding]; other site
573825004470	dimer interface [polypeptide binding]; other site
573825004471	putative catalytic residues [active]
573825004472	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
573825004473	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
573825004474	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
573825004475	active site
573825004476	intersubunit interactions; other site
573825004477	catalytic residue [active]
573825004478	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
573825004479	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825004480	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
573825004481	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
573825004482	RNA binding surface [nucleotide binding]; other site
573825004483	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
573825004484	active site
573825004485	lipoyl synthase; Provisional; Region: PRK05481
573825004486	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825004487	FeS/SAM binding site; other site
573825004488	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825004489	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825004490	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825004491	FecR protein; Region: FecR; pfam04773
573825004492	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
573825004493	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
573825004494	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
573825004495	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
573825004496	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
573825004497	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
573825004498	C factor cell-cell signaling protein; Provisional; Region: PRK09009
573825004499	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
573825004500	NADP binding site [chemical binding]; other site
573825004501	homodimer interface [polypeptide binding]; other site
573825004502	active site
573825004503	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
573825004504	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
573825004505	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
573825004506	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
573825004507	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
573825004508	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
573825004509	long-chain acyl-CoA synthetase; Region: PLN02736
573825004510	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
573825004511	acyl-activating enzyme (AAE) consensus motif; other site
573825004512	CoA binding site [chemical binding]; other site
573825004513	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
573825004514	putative AMP binding site [chemical binding]; other site
573825004515	putative active site [active]
573825004516	putative CoA binding site [chemical binding]; other site
573825004517	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
573825004518	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825004519	catalytic residues [active]
573825004520	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825004521	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
573825004522	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
573825004523	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
573825004524	active site
573825004525	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
573825004526	Part of AAA domain; Region: AAA_19; pfam13245
573825004527	Family description; Region: UvrD_C_2; pfam13538
573825004528	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
573825004529	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
573825004530	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
573825004531	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
573825004532	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
573825004533	Surface antigen; Region: Bac_surface_Ag; pfam01103
573825004534	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
573825004535	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
573825004536	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
573825004537	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
573825004538	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
573825004539	Walker A/P-loop; other site
573825004540	ATP binding site [chemical binding]; other site
573825004541	Q-loop/lid; other site
573825004542	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
573825004543	ABC transporter signature motif; other site
573825004544	Walker B; other site
573825004545	D-loop; other site
573825004546	H-loop/switch region; other site
573825004547	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
573825004548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825004549	NAD(P) binding site [chemical binding]; other site
573825004550	active site
573825004551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
573825004552	dimerization interface [polypeptide binding]; other site
573825004553	putative DNA binding site [nucleotide binding]; other site
573825004554	putative Zn2+ binding site [ion binding]; other site
573825004555	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
573825004556	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
573825004557	NADP binding site [chemical binding]; other site
573825004558	homopentamer interface [polypeptide binding]; other site
573825004559	substrate binding site [chemical binding]; other site
573825004560	active site
573825004561	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
573825004562	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
573825004563	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
573825004564	minor groove reading motif; other site
573825004565	helix-hairpin-helix signature motif; other site
573825004566	substrate binding pocket [chemical binding]; other site
573825004567	active site
573825004568	GTP-binding protein YchF; Reviewed; Region: PRK09601
573825004569	YchF GTPase; Region: YchF; cd01900
573825004570	G1 box; other site
573825004571	GTP/Mg2+ binding site [chemical binding]; other site
573825004572	Switch I region; other site
573825004573	G2 box; other site
573825004574	Switch II region; other site
573825004575	G3 box; other site
573825004576	G4 box; other site
573825004577	G5 box; other site
573825004578	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
573825004579	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
573825004580	dinuclear metal binding motif [ion binding]; other site
573825004581	prenyltransferase; Reviewed; Region: ubiA; PRK12886
573825004582	UbiA prenyltransferase family; Region: UbiA; pfam01040
573825004583	aromatic acid decarboxylase; Validated; Region: PRK05920
573825004584	Flavoprotein; Region: Flavoprotein; pfam02441
573825004585	Domain of unknown function DUF59; Region: DUF59; pfam01883
573825004586	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
573825004587	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
573825004588	Walker A motif; other site
573825004589	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
573825004590	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
573825004591	putative active site [active]
573825004592	putative metal binding site [ion binding]; other site
573825004593	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
573825004594	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
573825004595	E3 interaction surface; other site
573825004596	lipoyl attachment site [posttranslational modification]; other site
573825004597	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
573825004598	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
573825004599	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
573825004600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004601	Walker A motif; other site
573825004602	ATP binding site [chemical binding]; other site
573825004603	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
573825004604	Walker B motif; other site
573825004605	arginine finger; other site
573825004606	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
573825004607	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
573825004608	active site
573825004609	HslU subunit interaction site [polypeptide binding]; other site
573825004610	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
573825004611	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
573825004612	active site
573825004613	Int/Topo IB signature motif; other site
573825004614	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
573825004615	putative active site [active]
573825004616	catalytic residue [active]
573825004617	(R)-citramalate synthase; Provisional; Region: PRK09389
573825004618	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
573825004619	active site
573825004620	catalytic residues [active]
573825004621	metal binding site [ion binding]; metal-binding site
573825004622	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
573825004623	Smr domain; Region: Smr; pfam01713
573825004624	Uncharacterized conserved protein [Function unknown]; Region: COG4850
573825004625	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
573825004626	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
573825004627	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
573825004628	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
573825004629	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
573825004630	generic binding surface II; other site
573825004631	generic binding surface I; other site
573825004632	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14069
573825004633	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
573825004634	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
573825004635	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
573825004636	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
573825004637	active site
573825004638	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
573825004639	TSCPD domain; Region: TSCPD; pfam12637
573825004640	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
573825004641	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
573825004642	NAD(P) binding site [chemical binding]; other site
573825004643	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
573825004644	Cell division protein FtsA; Region: FtsA; pfam14450
573825004645	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
573825004646	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
573825004647	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
573825004648	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
573825004649	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
573825004650	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
573825004651	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
573825004652	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
573825004653	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
573825004654	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
573825004655	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
573825004656	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
573825004657	type II secretion system protein E; Region: type_II_gspE; TIGR02533
573825004658	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
573825004659	Walker A motif; other site
573825004660	ATP binding site [chemical binding]; other site
573825004661	Walker B motif; other site
573825004662	type II secretion system protein D; Region: type_II_gspD; TIGR02517
573825004663	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
573825004664	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
573825004665	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
573825004666	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
573825004667	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
573825004668	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825004669	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825004670	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825004671	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
573825004672	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
573825004673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004674	Walker A motif; other site
573825004675	ATP binding site [chemical binding]; other site
573825004676	Walker B motif; other site
573825004677	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
573825004678	hypothetical protein; Reviewed; Region: PRK12497
573825004679	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
573825004680	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
573825004681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825004682	Zn2+ binding site [ion binding]; other site
573825004683	Mg2+ binding site [ion binding]; other site
573825004684	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
573825004685	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
573825004686	RNA/DNA hybrid binding site [nucleotide binding]; other site
573825004687	active site
573825004688	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
573825004689	tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Provisional; Region: trmD; PRK14599
573825004690	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590
573825004691	RimM N-terminal domain; Region: RimM; pfam01782
573825004692	PRC-barrel domain; Region: PRC; pfam05239
573825004693	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
573825004694	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
573825004695	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
573825004696	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
573825004697	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
573825004698	substrate binding site [chemical binding]; other site
573825004699	hexamer interface [polypeptide binding]; other site
573825004700	metal binding site [ion binding]; metal-binding site
573825004701	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
573825004702	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
573825004703	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
573825004704	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
573825004705	putative active site [active]
573825004706	substrate binding site [chemical binding]; other site
573825004707	putative cosubstrate binding site; other site
573825004708	catalytic site [active]
573825004709	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
573825004710	substrate binding site [chemical binding]; other site
573825004711	primosome assembly protein PriA; Validated; Region: PRK05580
573825004712	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825004713	ATP binding site [chemical binding]; other site
573825004714	putative Mg++ binding site [ion binding]; other site
573825004715	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
573825004716	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
573825004717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004718	active site
573825004719	phosphorylation site [posttranslational modification]
573825004720	intermolecular recognition site; other site
573825004721	dimerization interface [polypeptide binding]; other site
573825004722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825004723	Walker A motif; other site
573825004724	ATP binding site [chemical binding]; other site
573825004725	Walker B motif; other site
573825004726	arginine finger; other site
573825004727	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
573825004728	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825004729	dimerization interface [polypeptide binding]; other site
573825004730	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825004731	dimer interface [polypeptide binding]; other site
573825004732	phosphorylation site [posttranslational modification]
573825004733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004734	ATP binding site [chemical binding]; other site
573825004735	Mg2+ binding site [ion binding]; other site
573825004736	G-X-G motif; other site
573825004737	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
573825004738	dimerization domain swap beta strand [polypeptide binding]; other site
573825004739	regulatory protein interface [polypeptide binding]; other site
573825004740	active site
573825004741	regulatory phosphorylation site [posttranslational modification]; other site
573825004742	HPr kinase/phosphorylase; Provisional; Region: PRK05428
573825004743	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
573825004744	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
573825004745	Hpr binding site; other site
573825004746	active site
573825004747	homohexamer subunit interaction site [polypeptide binding]; other site
573825004748	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
573825004749	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
573825004750	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
573825004751	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
573825004752	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
573825004753	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
573825004754	Walker A/P-loop; other site
573825004755	ATP binding site [chemical binding]; other site
573825004756	Q-loop/lid; other site
573825004757	ABC transporter signature motif; other site
573825004758	Walker B; other site
573825004759	D-loop; other site
573825004760	H-loop/switch region; other site
573825004761	OstA-like protein; Region: OstA; cl00844
573825004762	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
573825004763	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
573825004764	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
573825004765	CTP synthetase; Validated; Region: pyrG; PRK05380
573825004766	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
573825004767	Catalytic site [active]
573825004768	active site
573825004769	UTP binding site [chemical binding]; other site
573825004770	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
573825004771	active site
573825004772	putative oxyanion hole; other site
573825004773	catalytic triad [active]
573825004774	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
573825004775	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
573825004776	active site
573825004777	nucleotide binding site [chemical binding]; other site
573825004778	HIGH motif; other site
573825004779	KMSKS motif; other site
573825004780	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
573825004781	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
573825004782	putative ribose interaction site [chemical binding]; other site
573825004783	putative ADP binding site [chemical binding]; other site
573825004784	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
573825004785	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
573825004786	NlpC/P60 family; Region: NLPC_P60; pfam00877
573825004787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825004788	putative substrate translocation pore; other site
573825004789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825004790	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
573825004791	flagellin; Provisional; Region: PRK12804
573825004792	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
573825004793	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
573825004794	flagellin; Provisional; Region: PRK12804
573825004795	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
573825004796	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
573825004797	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825004798	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
573825004799	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
573825004800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825004801	PAS domain; Region: PAS_9; pfam13426
573825004802	putative active site [active]
573825004803	heme pocket [chemical binding]; other site
573825004804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825004805	dimer interface [polypeptide binding]; other site
573825004806	phosphorylation site [posttranslational modification]
573825004807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004808	ATP binding site [chemical binding]; other site
573825004809	Mg2+ binding site [ion binding]; other site
573825004810	G-X-G motif; other site
573825004811	Response regulator receiver domain; Region: Response_reg; pfam00072
573825004812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004813	active site
573825004814	phosphorylation site [posttranslational modification]
573825004815	intermolecular recognition site; other site
573825004816	dimerization interface [polypeptide binding]; other site
573825004817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004818	ATP binding site [chemical binding]; other site
573825004819	Mg2+ binding site [ion binding]; other site
573825004820	G-X-G motif; other site
573825004821	Response regulator receiver domain; Region: Response_reg; pfam00072
573825004822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004823	active site
573825004824	phosphorylation site [posttranslational modification]
573825004825	intermolecular recognition site; other site
573825004826	dimerization interface [polypeptide binding]; other site
573825004827	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825004828	anti sigma factor interaction site; other site
573825004829	regulatory phosphorylation site [posttranslational modification]; other site
573825004830	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
573825004831	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
573825004832	putative binding surface; other site
573825004833	active site
573825004834	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
573825004835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004836	ATP binding site [chemical binding]; other site
573825004837	Mg2+ binding site [ion binding]; other site
573825004838	G-X-G motif; other site
573825004839	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
573825004840	PAS domain; Region: PAS_10; pfam13596
573825004841	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
573825004842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
573825004843	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825004844	dimer interface [polypeptide binding]; other site
573825004845	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
573825004846	putative CheW interface [polypeptide binding]; other site
573825004847	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
573825004848	CheD chemotactic sensory transduction; Region: CheD; cl00810
573825004849	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
573825004850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825004851	active site
573825004852	phosphorylation site [posttranslational modification]
573825004853	intermolecular recognition site; other site
573825004854	dimerization interface [polypeptide binding]; other site
573825004855	CheB methylesterase; Region: CheB_methylest; pfam01339
573825004856	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
573825004857	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
573825004858	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825004859	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
573825004860	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
573825004861	carboxyltransferase (CT) interaction site; other site
573825004862	biotinylation site [posttranslational modification]; other site
573825004863	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
573825004864	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
573825004865	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
573825004866	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825004867	anti sigma factor interaction site; other site
573825004868	regulatory phosphorylation site [posttranslational modification]; other site
573825004869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825004870	GAF domain; Region: GAF; pfam01590
573825004871	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825004872	GAF domain; Region: GAF_3; pfam13492
573825004873	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825004874	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825004875	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825004876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
573825004877	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
573825004878	active site
573825004879	catalytic residues [active]
573825004880	metal binding site [ion binding]; metal-binding site
573825004881	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825004882	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
573825004883	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
573825004884	Leucine rich repeat; Region: LRR_8; pfam13855
573825004885	outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327
573825004886	Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310
573825004887	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825004888	Leucine-rich repeats; other site
573825004889	Substrate binding site [chemical binding]; other site
573825004890	Leucine rich repeat; Region: LRR_8; pfam13855
573825004891	Leucine rich repeat; Region: LRR_8; pfam13855
573825004892	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825004893	Leucine-rich repeats; other site
573825004894	Substrate binding site [chemical binding]; other site
573825004895	Leucine rich repeat; Region: LRR_8; pfam13855
573825004896	Leucine rich repeat; Region: LRR_8; pfam13855
573825004897	Leucine rich repeat; Region: LRR_8; pfam13855
573825004898	Leucine rich repeat; Region: LRR_8; pfam13855
573825004899	Leucine rich repeat; Region: LRR_8; pfam13855
573825004900	Leucine rich repeat; Region: LRR_8; pfam13855
573825004901	Leucine rich repeat; Region: LRR_8; pfam13855
573825004902	Leucine rich repeat; Region: LRR_8; pfam13855
573825004903	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
573825004904	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
573825004905	Predicted membrane protein [Function unknown]; Region: COG3766
573825004906	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
573825004907	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
573825004908	active site
573825004909	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
573825004910	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
573825004911	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
573825004912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825004913	S-adenosylmethionine binding site [chemical binding]; other site
573825004914	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825004915	anti sigma factor interaction site; other site
573825004916	regulatory phosphorylation site [posttranslational modification]; other site
573825004917	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825004918	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
573825004919	Walker A/P-loop; other site
573825004920	ATP binding site [chemical binding]; other site
573825004921	Q-loop/lid; other site
573825004922	ABC transporter signature motif; other site
573825004923	Walker B; other site
573825004924	D-loop; other site
573825004925	H-loop/switch region; other site
573825004926	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
573825004927	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
573825004928	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
573825004929	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
573825004930	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
573825004931	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
573825004932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825004933	binding surface
573825004934	TPR motif; other site
573825004935	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825004936	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825004937	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825004938	ligand binding site [chemical binding]; other site
573825004939	flexible hinge region; other site
573825004940	putative switch regulator; other site
573825004941	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
573825004942	non-specific DNA interactions [nucleotide binding]; other site
573825004943	DNA binding site [nucleotide binding]
573825004944	sequence specific DNA binding site [nucleotide binding]; other site
573825004945	putative cAMP binding site [chemical binding]; other site
573825004946	Protein of unknown function (DUF342); Region: DUF342; pfam03961
573825004947	TfoX N-terminal domain; Region: TfoX_N; pfam04993
573825004948	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825004949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825004950	ATP binding site [chemical binding]; other site
573825004951	Mg2+ binding site [ion binding]; other site
573825004952	G-X-G motif; other site
573825004953	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
573825004954	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
573825004955	active site
573825004956	Int/Topo IB signature motif; other site
573825004957	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825004958	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
573825004959	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
573825004960	catalytic triad [active]
573825004961	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825004962	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825004963	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
573825004964	active site
573825004965	oxyanion hole [active]
573825004966	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825004967	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825004968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825004969	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825004970	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
573825004971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
573825004972	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825004973	Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461
573825004974	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
573825004975	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
573825004976	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
573825004977	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
573825004978	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
573825004979	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
573825004980	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
573825004981	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
573825004982	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825004983	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825004984	PGAP1-like protein; Region: PGAP1; pfam07819
573825004985	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
573825004986	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
573825004987	substrate binding site [chemical binding]; other site
573825004988	glutamase interaction surface [polypeptide binding]; other site
573825004989	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
573825004990	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
573825004991	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
573825004992	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
573825004993	Bacterial sugar transferase; Region: Bac_transf; pfam02397
573825004994	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
573825004995	Bacitracin resistance protein BacA; Region: BacA; pfam02673
573825004996	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
573825004997	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
573825004998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825004999	ATP binding site [chemical binding]; other site
573825005000	putative Mg++ binding site [ion binding]; other site
573825005001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825005002	nucleotide binding region [chemical binding]; other site
573825005003	ATP-binding site [chemical binding]; other site
573825005004	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
573825005005	pantoate--beta-alanine ligase; Region: panC; TIGR00018
573825005006	Pantoate-beta-alanine ligase; Region: PanC; cd00560
573825005007	active site
573825005008	ATP-binding site [chemical binding]; other site
573825005009	pantoate-binding site; other site
573825005010	HXXH motif; other site
573825005011	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
573825005012	histidinol dehydrogenase; Region: hisD; TIGR00069
573825005013	NAD binding site [chemical binding]; other site
573825005014	dimerization interface [polypeptide binding]; other site
573825005015	product binding site; other site
573825005016	substrate binding site [chemical binding]; other site
573825005017	zinc binding site [ion binding]; other site
573825005018	catalytic residues [active]
573825005019	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
573825005020	putative active site [active]
573825005021	putative catalytic site [active]
573825005022	putative DNA binding site [nucleotide binding]; other site
573825005023	putative phosphate binding site [ion binding]; other site
573825005024	metal binding site A [ion binding]; metal-binding site
573825005025	putative AP binding site [nucleotide binding]; other site
573825005026	putative metal binding site B [ion binding]; other site
573825005027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825005028	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825005029	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825005031	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825005032	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005033	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825005034	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
573825005035	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
573825005036	MOFRL family; Region: MOFRL; pfam05161
573825005037	Response regulator receiver domain; Region: Response_reg; pfam00072
573825005038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005039	active site
573825005040	phosphorylation site [posttranslational modification]
573825005041	intermolecular recognition site; other site
573825005042	dimerization interface [polypeptide binding]; other site
573825005043	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005044	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005045	metal binding site [ion binding]; metal-binding site
573825005046	active site
573825005047	I-site; other site
573825005048	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
573825005049	dimerization interface [polypeptide binding]; other site
573825005050	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
573825005051	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825005052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005053	active site
573825005054	phosphorylation site [posttranslational modification]
573825005055	intermolecular recognition site; other site
573825005056	PAS domain S-box; Region: sensory_box; TIGR00229
573825005057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005058	putative active site [active]
573825005059	heme pocket [chemical binding]; other site
573825005060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825005061	Histidine kinase; Region: HisKA_2; pfam07568
573825005062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005063	ATP binding site [chemical binding]; other site
573825005064	Mg2+ binding site [ion binding]; other site
573825005065	G-X-G motif; other site
573825005066	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
573825005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005068	ATP binding site [chemical binding]; other site
573825005069	Mg2+ binding site [ion binding]; other site
573825005070	G-X-G motif; other site
573825005071	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
573825005072	active site
573825005073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825005074	dimerization interface [polypeptide binding]; other site
573825005075	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825005076	cyclase homology domain; Region: CHD; cd07302
573825005077	nucleotidyl binding site; other site
573825005078	metal binding site [ion binding]; metal-binding site
573825005079	dimer interface [polypeptide binding]; other site
573825005080	FecR protein; Region: FecR; pfam04773
573825005081	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
573825005082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825005083	Walker A/P-loop; other site
573825005084	ATP binding site [chemical binding]; other site
573825005085	Q-loop/lid; other site
573825005086	ABC transporter signature motif; other site
573825005087	Walker B; other site
573825005088	D-loop; other site
573825005089	H-loop/switch region; other site
573825005090	ABC transporter; Region: ABC_tran_2; pfam12848
573825005091	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825005092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005093	PAS domain; Region: PAS_9; pfam13426
573825005094	putative active site [active]
573825005095	heme pocket [chemical binding]; other site
573825005096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
573825005097	PAS fold; Region: PAS_4; pfam08448
573825005098	putative active site [active]
573825005099	heme pocket [chemical binding]; other site
573825005100	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825005101	Histidine kinase; Region: HisKA_2; pfam07568
573825005102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005103	ATP binding site [chemical binding]; other site
573825005104	Mg2+ binding site [ion binding]; other site
573825005105	G-X-G motif; other site
573825005106	PAS domain; Region: PAS_9; pfam13426
573825005107	PAS domain S-box; Region: sensory_box; TIGR00229
573825005108	PAS domain S-box; Region: sensory_box; TIGR00229
573825005109	PAS domain; Region: PAS_8; pfam13188
573825005110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825005111	dimer interface [polypeptide binding]; other site
573825005112	phosphorylation site [posttranslational modification]
573825005113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005114	ATP binding site [chemical binding]; other site
573825005115	Mg2+ binding site [ion binding]; other site
573825005116	G-X-G motif; other site
573825005117	Response regulator receiver domain; Region: Response_reg; pfam00072
573825005118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005119	active site
573825005120	phosphorylation site [posttranslational modification]
573825005121	intermolecular recognition site; other site
573825005122	dimerization interface [polypeptide binding]; other site
573825005123	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825005124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825005125	ligand binding site [chemical binding]; other site
573825005126	flexible hinge region; other site
573825005127	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
573825005128	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825005129	poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332
573825005130	poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011
573825005131	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
573825005132	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825005133	PAS domain S-box; Region: sensory_box; TIGR00229
573825005134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005135	putative active site [active]
573825005136	heme pocket [chemical binding]; other site
573825005137	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825005138	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825005139	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825005140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825005141	dimer interface [polypeptide binding]; other site
573825005142	phosphorylation site [posttranslational modification]
573825005143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005144	ATP binding site [chemical binding]; other site
573825005145	Mg2+ binding site [ion binding]; other site
573825005146	G-X-G motif; other site
573825005147	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
573825005148	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
573825005149	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
573825005150	RNA recognition motif; Region: RRM; smart00360
573825005151	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
573825005152	serine/threonine protein kinase; Provisional; Region: PRK11768
573825005153	Phosphate transporter family; Region: PHO4; cl00396
573825005154	Phosphate transporter family; Region: PHO4; cl00396
573825005155	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825005156	Coenzyme A binding pocket [chemical binding]; other site
573825005157	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
573825005158	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
573825005159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825005160	Walker A motif; other site
573825005161	ATP binding site [chemical binding]; other site
573825005162	Walker B motif; other site
573825005163	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
573825005164	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
573825005165	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
573825005166	oligomer interface [polypeptide binding]; other site
573825005167	active site residues [active]
573825005168	trigger factor; Region: tig; TIGR00115
573825005169	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
573825005170	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
573825005171	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
573825005172	active site
573825005173	catalytic triad [active]
573825005174	oxyanion hole [active]
573825005175	switch loop; other site
573825005176	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
573825005177	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
573825005178	putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539
573825005179	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825005180	FeS/SAM binding site; other site
573825005181	HemN C-terminal domain; Region: HemN_C; pfam06969
573825005182	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825005183	active site
573825005184	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
573825005185	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
573825005186	putative valine binding site [chemical binding]; other site
573825005187	dimer interface [polypeptide binding]; other site
573825005188	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
573825005189	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
573825005190	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
573825005191	PYR/PP interface [polypeptide binding]; other site
573825005192	dimer interface [polypeptide binding]; other site
573825005193	TPP binding site [chemical binding]; other site
573825005194	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
573825005195	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
573825005196	TPP-binding site [chemical binding]; other site
573825005197	dimer interface [polypeptide binding]; other site
573825005198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005199	TPR repeat; Region: TPR_11; pfam13414
573825005200	binding surface
573825005201	TPR motif; other site
573825005202	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825005203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005204	binding surface
573825005205	TPR motif; other site
573825005206	TPR repeat; Region: TPR_11; pfam13414
573825005207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005208	binding surface
573825005209	TPR motif; other site
573825005210	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825005211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005212	TPR motif; other site
573825005213	binding surface
573825005214	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
573825005215	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825005216	dimer interface [polypeptide binding]; other site
573825005217	putative CheW interface [polypeptide binding]; other site
573825005218	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
573825005219	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
573825005220	ABC1 family; Region: ABC1; cl17513
573825005221	FeoA domain; Region: FeoA; pfam04023
573825005222	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
573825005223	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
573825005224	G1 box; other site
573825005225	GTP/Mg2+ binding site [chemical binding]; other site
573825005226	Switch I region; other site
573825005227	G2 box; other site
573825005228	G3 box; other site
573825005229	Switch II region; other site
573825005230	G4 box; other site
573825005231	G5 box; other site
573825005232	Nucleoside recognition; Region: Gate; pfam07670
573825005233	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
573825005234	Nucleoside recognition; Region: Gate; pfam07670
573825005235	Sulfatase; Region: Sulfatase; pfam00884
573825005236	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
573825005237	NeuB family; Region: NeuB; pfam03102
573825005238	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
573825005239	sugar binding site [chemical binding]; other site
573825005240	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825005241	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825005242	Uncharacterized conserved protein [Function unknown]; Region: COG3268
573825005243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825005244	NAD(P) binding site [chemical binding]; other site
573825005245	flagellar assembly protein H; Validated; Region: fliH; PRK06669
573825005246	Flagellar assembly protein FliH; Region: FliH; pfam02108
573825005247	FliG C-terminal domain; Region: FliG_C; pfam01706
573825005248	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
573825005249	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
573825005250	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
573825005251	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
573825005252	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
573825005253	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
573825005254	Walker A motif; other site
573825005255	ATP binding site [chemical binding]; other site
573825005256	Walker B motif; other site
573825005257	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
573825005258	TOBE domain; Region: TOBE_2; pfam08402
573825005259	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
573825005260	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
573825005261	hypothetical protein; Provisional; Region: PRK04323
573825005262	Protein of unknown function (DUF342); Region: DUF342; pfam03961
573825005263	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
573825005264	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825005265	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825005266	DNA binding residues [nucleotide binding]
573825005267	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
573825005268	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
573825005269	P-loop; other site
573825005270	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724
573825005271	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
573825005272	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
573825005273	FHIPEP family; Region: FHIPEP; pfam00771
573825005274	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12773
573825005275	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
573825005276	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
573825005277	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
573825005278	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
573825005279	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
573825005280	flagellar motor switch protein; Validated; Region: PRK08119
573825005281	flagellar motor switch protein FliN; Region: fliN; TIGR02480
573825005282	Protein of unknown function (DUF971); Region: DUF971; pfam06155
573825005283	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
573825005284	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
573825005285	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
573825005286	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
573825005287	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
573825005288	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
573825005289	classical (c) SDRs; Region: SDR_c; cd05233
573825005290	NAD(P) binding site [chemical binding]; other site
573825005291	active site
573825005292	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
573825005293	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
573825005294	C-terminal domain interface [polypeptide binding]; other site
573825005295	GSH binding site (G-site) [chemical binding]; other site
573825005296	dimer interface [polypeptide binding]; other site
573825005297	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
573825005298	putative N-terminal domain interface [polypeptide binding]; other site
573825005299	putative dimer interface [polypeptide binding]; other site
573825005300	putative substrate binding pocket (H-site) [chemical binding]; other site
573825005301	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
573825005302	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
573825005303	active site
573825005304	Zn binding site [ion binding]; other site
573825005305	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
573825005306	putative active site [active]
573825005307	putative catalytic site [active]
573825005308	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
573825005309	active site 2 [active]
573825005310	active site 1 [active]
573825005311	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825005312	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
573825005313	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
573825005314	NAD(P) binding site [chemical binding]; other site
573825005315	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
573825005316	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
573825005317	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
573825005318	PYR/PP interface [polypeptide binding]; other site
573825005319	dimer interface [polypeptide binding]; other site
573825005320	TPP binding site [chemical binding]; other site
573825005321	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
573825005322	S-adenosylmethionine synthetase; Validated; Region: PRK05250
573825005323	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
573825005324	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
573825005325	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
573825005326	ParB-like nuclease domain; Region: ParBc; pfam02195
573825005327	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
573825005328	Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103
573825005329	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825005330	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825005331	active site
573825005332	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
573825005333	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
573825005334	N-terminal plug; other site
573825005335	ligand-binding site [chemical binding]; other site
573825005336	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
573825005337	NADH(P)-binding; Region: NAD_binding_10; pfam13460
573825005338	NAD binding site [chemical binding]; other site
573825005339	active site
573825005340	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
573825005341	cyclase homology domain; Region: CHD; cd07302
573825005342	nucleotidyl binding site; other site
573825005343	metal binding site [ion binding]; metal-binding site
573825005344	dimer interface [polypeptide binding]; other site
573825005345	Protein of unknown function (DUF962); Region: DUF962; pfam06127
573825005346	photolyase PhrII; Region: phr2; TIGR00591
573825005347	putative transposase OrfB; Reviewed; Region: PHA02517
573825005348	Integrase core domain; Region: rve; pfam00665
573825005349	Integrase core domain; Region: rve_3; pfam13683
573825005350	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
573825005351	oligomerisation interface [polypeptide binding]; other site
573825005352	mobile loop; other site
573825005353	roof hairpin; other site
573825005354	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
573825005355	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
573825005356	ring oligomerisation interface [polypeptide binding]; other site
573825005357	ATP/Mg binding site [chemical binding]; other site
573825005358	stacking interactions; other site
573825005359	hinge regions; other site
573825005360	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
573825005361	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
573825005362	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825005363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825005364	S-adenosylmethionine binding site [chemical binding]; other site
573825005365	Glycoprotein hormone; Region: Hormone_6; cl02448
573825005366	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825005367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825005368	S-adenosylmethionine binding site [chemical binding]; other site
573825005369	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
573825005370	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
573825005371	Rod binding protein; Region: Rod-binding; pfam10135
573825005372	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
573825005373	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
573825005374	Flagellar L-ring protein; Region: FlgH; cl17277
573825005375	SAF-like; Region: SAF_2; pfam13144
573825005376	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
573825005377	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
573825005378	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
573825005379	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
573825005380	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
573825005381	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
573825005382	metal binding site [ion binding]; metal-binding site
573825005383	dimer interface [polypeptide binding]; other site
573825005384	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825005385	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825005386	putative transposase OrfB; Reviewed; Region: PHA02517
573825005387	Integrase core domain; Region: rve; pfam00665
573825005388	Integrase core domain; Region: rve_3; pfam13683
573825005389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825005390	binding surface
573825005391	TPR motif; other site
573825005392	Restriction endonuclease; Region: Mrr_cat; pfam04471
573825005393	potential frameshift: common BLAST hit: gi|294495970|ref|YP_003542463.1| KAP P-loop domain protein
573825005394	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
573825005395	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825005396	proline aminopeptidase P II; Provisional; Region: PRK10879
573825005397	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
573825005398	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
573825005399	active site
573825005400	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
573825005401	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
573825005402	putative active site [active]
573825005403	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
573825005404	active site
573825005405	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
573825005406	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
573825005407	heme binding site [chemical binding]; other site
573825005408	ferroxidase pore; other site
573825005409	ferroxidase diiron center [ion binding]; other site
573825005410	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
573825005411	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
573825005412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825005413	acetylglutamate kinase; Provisional; Region: PRK04531
573825005414	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
573825005415	DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish; Region: DUF619-NAGS-U; cd04265
573825005416	Protein of unknown function, DUF393; Region: DUF393; pfam04134
573825005417	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
573825005418	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825005419	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
573825005420	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
573825005421	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
573825005422	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
573825005423	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
573825005424	motif II; other site
573825005425	Sporulation and spore germination; Region: Germane; pfam10646
573825005426	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005428	metal binding site [ion binding]; metal-binding site
573825005429	active site
573825005430	I-site; other site
573825005431	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
573825005432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825005433	FeS/SAM binding site; other site
573825005434	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
573825005435	Ligand binding site; other site
573825005436	Putative Catalytic site; other site
573825005437	DXD motif; other site
573825005438	GtrA-like protein; Region: GtrA; pfam04138
573825005439	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
573825005440	Cysteine-rich domain; Region: CCG; pfam02754
573825005441	Cysteine-rich domain; Region: CCG; pfam02754
573825005442	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825005443	Histidine kinase; Region: HisKA_2; pfam07568
573825005444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
573825005445	Mg2+ binding site [ion binding]; other site
573825005446	G-X-G motif; other site
573825005447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825005448	Histidine kinase; Region: HisKA_2; pfam07568
573825005449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
573825005450	Mg2+ binding site [ion binding]; other site
573825005451	G-X-G motif; other site
573825005452	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
573825005453	Protein of unknown function (DUF445); Region: DUF445; pfam04286
573825005454	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
573825005455	active site
573825005456	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
573825005457	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
573825005458	FMN binding site [chemical binding]; other site
573825005459	substrate binding site [chemical binding]; other site
573825005460	putative catalytic residue [active]
573825005461	Uncharacterized conserved protein [Function unknown]; Region: COG1359
573825005462	Predicted transcriptional regulator [Transcription]; Region: COG1959
573825005463	Transcriptional regulator; Region: Rrf2; pfam02082
573825005464	Transcriptional regulator; Region: Rrf2; cl17282
573825005465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825005466	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825005467	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005468	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
573825005469	Domain of unknown function (DU1801); Region: DUF1801; cl17490
573825005470	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
573825005471	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
573825005472	G1 box; other site
573825005473	putative GEF interaction site [polypeptide binding]; other site
573825005474	GTP/Mg2+ binding site [chemical binding]; other site
573825005475	Switch I region; other site
573825005476	G2 box; other site
573825005477	G3 box; other site
573825005478	Switch II region; other site
573825005479	G4 box; other site
573825005480	G5 box; other site
573825005481	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
573825005482	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
573825005483	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
573825005484	carboxyltransferase (CT) interaction site; other site
573825005485	biotinylation site [posttranslational modification]; other site
573825005486	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
573825005487	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
573825005488	ATP-grasp domain; Region: ATP-grasp_4; cl17255
573825005489	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
573825005490	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
573825005491	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
573825005492	putative acyl-acceptor binding pocket; other site
573825005493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
573825005494	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
573825005495	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
573825005496	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
573825005497	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
573825005498	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
573825005499	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
573825005500	substrate binding pocket [chemical binding]; other site
573825005501	membrane-bound complex binding site; other site
573825005502	hinge residues; other site
573825005503	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
573825005504	active site
573825005505	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
573825005506	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
573825005507	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
573825005508	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
573825005509	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
573825005510	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
573825005511	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
573825005512	rod shape-determining protein MreC; Provisional; Region: PRK13922
573825005513	rod shape-determining protein MreC; Region: MreC; pfam04085
573825005514	rod shape-determining protein MreB; Provisional; Region: PRK13927
573825005515	MreB and similar proteins; Region: MreB_like; cd10225
573825005516	nucleotide binding site [chemical binding]; other site
573825005517	Mg binding site [ion binding]; other site
573825005518	putative protofilament interaction site [polypeptide binding]; other site
573825005519	RodZ interaction site [polypeptide binding]; other site
573825005520	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
573825005521	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
573825005522	A new structural DNA glycosylase; Region: AlkD_like; cl11434
573825005523	active site
573825005524	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825005525	GAF domain; Region: GAF_3; pfam13492
573825005526	GAF domain; Region: GAF; pfam01590
573825005527	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
573825005528	SLBB domain; Region: SLBB; pfam10531
573825005529	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444
573825005530	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
573825005531	gamma subunit interface [polypeptide binding]; other site
573825005532	epsilon subunit interface [polypeptide binding]; other site
573825005533	LBP interface [polypeptide binding]; other site
573825005534	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
573825005535	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
573825005536	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
573825005537	alpha subunit interaction interface [polypeptide binding]; other site
573825005538	Walker A motif; other site
573825005539	ATP binding site [chemical binding]; other site
573825005540	Walker B motif; other site
573825005541	inhibitor binding site; inhibition site
573825005542	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
573825005543	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
573825005544	core domain interface [polypeptide binding]; other site
573825005545	delta subunit interface [polypeptide binding]; other site
573825005546	epsilon subunit interface [polypeptide binding]; other site
573825005547	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
573825005548	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
573825005549	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
573825005550	beta subunit interaction interface [polypeptide binding]; other site
573825005551	Walker A motif; other site
573825005552	ATP binding site [chemical binding]; other site
573825005553	Walker B motif; other site
573825005554	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
573825005555	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13434
573825005556	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
573825005557	F0F1 ATP synthase subunit B; Provisional; Region: PRK13460
573825005558	F0F1 ATP synthase subunit A; Provisional; Region: PRK13417
573825005559	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
573825005560	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
573825005561	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
573825005562	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
573825005563	Catalytic site [active]
573825005564	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
573825005565	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
573825005566	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825005567	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825005568	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
573825005569	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
573825005570	oligomer interface [polypeptide binding]; other site
573825005571	metal binding site [ion binding]; metal-binding site
573825005572	metal binding site [ion binding]; metal-binding site
573825005573	putative Cl binding site [ion binding]; other site
573825005574	aspartate ring; other site
573825005575	basic sphincter; other site
573825005576	hydrophobic gate; other site
573825005577	periplasmic entrance; other site
573825005578	FecR protein; Region: FecR; pfam04773
573825005579	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
573825005580	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
573825005581	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
573825005582	TPR repeat; Region: TPR_11; pfam13414
573825005583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005584	binding surface
573825005585	TPR motif; other site
573825005586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825005587	binding surface
573825005588	TPR repeat; Region: TPR_11; pfam13414
573825005589	TPR motif; other site
573825005590	TPR repeat; Region: TPR_11; pfam13414
573825005591	PAS domain S-box; Region: sensory_box; TIGR00229
573825005592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005593	putative active site [active]
573825005594	heme pocket [chemical binding]; other site
573825005595	PAS domain S-box; Region: sensory_box; TIGR00229
573825005596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005597	putative active site [active]
573825005598	heme pocket [chemical binding]; other site
573825005599	PAS domain S-box; Region: sensory_box; TIGR00229
573825005600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005601	putative active site [active]
573825005602	heme pocket [chemical binding]; other site
573825005603	PAS domain S-box; Region: sensory_box; TIGR00229
573825005604	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005605	putative active site [active]
573825005606	heme pocket [chemical binding]; other site
573825005607	PAS domain S-box; Region: sensory_box; TIGR00229
573825005608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005609	putative active site [active]
573825005610	heme pocket [chemical binding]; other site
573825005611	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825005612	GAF domain; Region: GAF; pfam01590
573825005613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825005614	dimer interface [polypeptide binding]; other site
573825005615	phosphorylation site [posttranslational modification]
573825005616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825005617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005618	ATP binding site [chemical binding]; other site
573825005619	Mg2+ binding site [ion binding]; other site
573825005620	G-X-G motif; other site
573825005621	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
573825005622	FeS assembly protein SufB; Region: sufB; TIGR01980
573825005623	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
573825005624	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
573825005625	dimer interface [polypeptide binding]; other site
573825005626	decamer (pentamer of dimers) interface [polypeptide binding]; other site
573825005627	catalytic triad [active]
573825005628	peroxidatic and resolving cysteines [active]
573825005629	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
573825005630	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825005631	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825005632	dimer interface [polypeptide binding]; other site
573825005633	putative CheW interface [polypeptide binding]; other site
573825005634	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
573825005635	YceI-like domain; Region: YceI; pfam04264
573825005636	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
573825005637	CoenzymeA binding site [chemical binding]; other site
573825005638	subunit interaction site [polypeptide binding]; other site
573825005639	PHB binding site; other site
573825005640	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825005641	Response regulator receiver domain; Region: Response_reg; pfam00072
573825005642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005643	active site
573825005644	phosphorylation site [posttranslational modification]
573825005645	intermolecular recognition site; other site
573825005646	dimerization interface [polypeptide binding]; other site
573825005647	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825005648	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825005649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
573825005650	active site
573825005651	phosphorylation site [posttranslational modification]
573825005652	intermolecular recognition site; other site
573825005653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825005654	dimer interface [polypeptide binding]; other site
573825005655	phosphorylation site [posttranslational modification]
573825005656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005657	ATP binding site [chemical binding]; other site
573825005658	Mg2+ binding site [ion binding]; other site
573825005659	G-X-G motif; other site
573825005660	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825005661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005662	active site
573825005663	phosphorylation site [posttranslational modification]
573825005664	intermolecular recognition site; other site
573825005665	dimerization interface [polypeptide binding]; other site
573825005666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005667	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
573825005668	putative active site [active]
573825005669	heme pocket [chemical binding]; other site
573825005670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825005671	dimer interface [polypeptide binding]; other site
573825005672	phosphorylation site [posttranslational modification]
573825005673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825005674	ATP binding site [chemical binding]; other site
573825005675	Mg2+ binding site [ion binding]; other site
573825005676	G-X-G motif; other site
573825005677	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
573825005678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005679	putative active site [active]
573825005680	heme pocket [chemical binding]; other site
573825005681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005682	putative active site [active]
573825005683	heme pocket [chemical binding]; other site
573825005684	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825005685	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825005686	ligand binding site [chemical binding]; other site
573825005687	flexible hinge region; other site
573825005688	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
573825005689	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
573825005690	active site
573825005691	nucleophile elbow; other site
573825005692	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825005693	GAF domain; Region: GAF; pfam01590
573825005694	cyclase homology domain; Region: CHD; cd07302
573825005695	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825005696	nucleotidyl binding site; other site
573825005697	metal binding site [ion binding]; metal-binding site
573825005698	dimer interface [polypeptide binding]; other site
573825005699	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
573825005700	ornithine carbamoyltransferase; Provisional; Region: PRK14804
573825005701	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
573825005702	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
573825005703	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
573825005704	PemK-like protein; Region: PemK; pfam02452
573825005705	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
573825005706	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
573825005707	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
573825005708	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825005709	non-specific DNA binding site [nucleotide binding]; other site
573825005710	salt bridge; other site
573825005711	sequence-specific DNA binding site [nucleotide binding]; other site
573825005712	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825005713	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825005714	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825005715	Zn2+ binding site [ion binding]; other site
573825005716	Mg2+ binding site [ion binding]; other site
573825005717	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825005718	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
573825005719	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
573825005720	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
573825005721	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
573825005722	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
573825005723	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
573825005724	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
573825005725	Putative Ig domain; Region: He_PIG; pfam05345
573825005726	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825005727	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
573825005728	catalytic site [active]
573825005729	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825005730	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825005731	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005732	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
573825005733	Predicted amidohydrolase [General function prediction only]; Region: COG0388
573825005734	active site
573825005735	catalytic triad [active]
573825005736	dimer interface [polypeptide binding]; other site
573825005737	Leucine rich repeat; Region: LRR_8; pfam13855
573825005738	Leucine rich repeat; Region: LRR_8; pfam13855
573825005739	Leucine rich repeat; Region: LRR_8; pfam13855
573825005740	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
573825005741	active site residue [active]
573825005742	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
573825005743	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
573825005744	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
573825005745	Protein of unknown function (DUF342); Region: DUF342; pfam03961
573825005746	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
573825005747	Predicted esterase [General function prediction only]; Region: COG0400
573825005748	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
573825005749	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
573825005750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825005751	S-adenosylmethionine binding site [chemical binding]; other site
573825005752	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
573825005753	active site
573825005754	NTP binding site [chemical binding]; other site
573825005755	metal binding triad [ion binding]; metal-binding site
573825005756	antibiotic binding site [chemical binding]; other site
573825005757	HEPN domain; Region: HEPN; pfam05168
573825005758	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
573825005759	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
573825005760	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
573825005761	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
573825005762	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825005763	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
573825005764	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
573825005765	metal binding site 2 [ion binding]; metal-binding site
573825005766	putative DNA binding helix; other site
573825005767	structural Zn2+ binding site [ion binding]; other site
573825005768	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
573825005769	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
573825005770	transmembrane helices; other site
573825005771	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
573825005772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
573825005773	non-specific DNA binding site [nucleotide binding]; other site
573825005774	salt bridge; other site
573825005775	sequence-specific DNA binding site [nucleotide binding]; other site
573825005776	Cupin domain; Region: Cupin_2; pfam07883
573825005777	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
573825005778	active site
573825005779	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
573825005780	active site
573825005781	homodimer interface [polypeptide binding]; other site
573825005782	SAM binding site [chemical binding]; other site
573825005783	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
573825005784	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
573825005785	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825005786	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825005787	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
573825005788	RuvA N terminal domain; Region: RuvA_N; pfam01330
573825005789	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
573825005790	Predicted transcriptional regulator [Transcription]; Region: COG2378
573825005791	HTH domain; Region: HTH_11; pfam08279
573825005792	WYL domain; Region: WYL; pfam13280
573825005793	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825005794	NAD(P) binding site [chemical binding]; other site
573825005795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825005796	active site
573825005797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825005798	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825005799	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005800	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825005801	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825005802	Zn2+ binding site [ion binding]; other site
573825005803	Mg2+ binding site [ion binding]; other site
573825005804	DNA repair protein RadA; Provisional; Region: PRK11823
573825005805	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
573825005806	Walker A motif; other site
573825005807	ATP binding site [chemical binding]; other site
573825005808	Walker B motif; other site
573825005809	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
573825005810	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
573825005811	catalytic site [active]
573825005812	putative active site [active]
573825005813	putative substrate binding site [chemical binding]; other site
573825005814	Melibiase; Region: Melibiase; pfam02065
573825005815	Response regulator receiver domain; Region: Response_reg; pfam00072
573825005816	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005817	active site
573825005818	phosphorylation site [posttranslational modification]
573825005819	intermolecular recognition site; other site
573825005820	dimerization interface [polypeptide binding]; other site
573825005821	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825005822	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
573825005823	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
573825005824	putative active site [active]
573825005825	Zn binding site [ion binding]; other site
573825005826	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
573825005827	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
573825005828	domain interfaces; other site
573825005829	active site
573825005830	PAS domain S-box; Region: sensory_box; TIGR00229
573825005831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005832	putative active site [active]
573825005833	heme pocket [chemical binding]; other site
573825005834	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005836	metal binding site [ion binding]; metal-binding site
573825005837	active site
573825005838	I-site; other site
573825005839	PAS domain S-box; Region: sensory_box; TIGR00229
573825005840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005841	putative active site [active]
573825005842	heme pocket [chemical binding]; other site
573825005843	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005844	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005845	metal binding site [ion binding]; metal-binding site
573825005846	active site
573825005847	I-site; other site
573825005848	PAS domain S-box; Region: sensory_box; TIGR00229
573825005849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005850	putative active site [active]
573825005851	heme pocket [chemical binding]; other site
573825005852	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005853	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005854	metal binding site [ion binding]; metal-binding site
573825005855	active site
573825005856	I-site; other site
573825005857	PAS domain S-box; Region: sensory_box; TIGR00229
573825005858	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005859	putative active site [active]
573825005860	heme pocket [chemical binding]; other site
573825005861	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005862	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005863	metal binding site [ion binding]; metal-binding site
573825005864	active site
573825005865	I-site; other site
573825005866	PAS domain S-box; Region: sensory_box; TIGR00229
573825005867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005868	putative active site [active]
573825005869	heme pocket [chemical binding]; other site
573825005870	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005871	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005872	metal binding site [ion binding]; metal-binding site
573825005873	active site
573825005874	I-site; other site
573825005875	PAS domain S-box; Region: sensory_box; TIGR00229
573825005876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005877	putative active site [active]
573825005878	heme pocket [chemical binding]; other site
573825005879	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005880	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005881	metal binding site [ion binding]; metal-binding site
573825005882	active site
573825005883	I-site; other site
573825005884	PAS domain S-box; Region: sensory_box; TIGR00229
573825005885	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825005886	putative active site [active]
573825005887	heme pocket [chemical binding]; other site
573825005888	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825005889	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825005890	metal binding site [ion binding]; metal-binding site
573825005891	active site
573825005892	I-site; other site
573825005893	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
573825005894	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
573825005895	Cl- selectivity filter; other site
573825005896	Cl- binding residues [ion binding]; other site
573825005897	pore gating glutamate residue; other site
573825005898	dimer interface [polypeptide binding]; other site
573825005899	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
573825005900	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
573825005901	dimerization interface [polypeptide binding]; other site
573825005902	putative ATP binding site [chemical binding]; other site
573825005903	FecR protein; Region: FecR; pfam04773
573825005904	Bor protein; Region: Lambda_Bor; pfam06291
573825005905	Galactose oxidase, central domain; Region: Kelch_3; cl02701
573825005906	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
573825005907	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
573825005908	Galactose oxidase, central domain; Region: Kelch_3; cl02701
573825005909	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
573825005910	alpha-glucosidase; Provisional; Region: PRK10426
573825005911	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
573825005912	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
573825005913	putative active site [active]
573825005914	putative catalytic site [active]
573825005915	Rhodanese Homology Domain; Region: RHOD; smart00450
573825005916	active site residue [active]
573825005917	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
573825005918	active site residue [active]
573825005919	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
573825005920	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
573825005921	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825005922	protein binding site [polypeptide binding]; other site
573825005923	Response regulator receiver domain; Region: Response_reg; pfam00072
573825005924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825005925	active site
573825005926	phosphorylation site [posttranslational modification]
573825005927	intermolecular recognition site; other site
573825005928	dimerization interface [polypeptide binding]; other site
573825005929	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825005930	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
573825005931	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
573825005932	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
573825005933	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
573825005934	active site
573825005935	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
573825005936	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
573825005937	putative acyl-acceptor binding pocket; other site
573825005938	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
573825005939	B12 binding site [chemical binding]; other site
573825005940	cobalt ligand [ion binding]; other site
573825005941	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
573825005942	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
573825005943	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678
573825005944	putative active site [active]
573825005945	putative substrate binding site [chemical binding]; other site
573825005946	putative coenzyme B12 binding site [chemical binding]; other site
573825005947	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
573825005948	active site
573825005949	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825005950	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825005951	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
573825005952	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
573825005953	Leucine rich repeat; Region: LRR_8; pfam13855
573825005954	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825005955	Leucine-rich repeats; other site
573825005956	Substrate binding site [chemical binding]; other site
573825005957	Leucine rich repeat; Region: LRR_8; pfam13855
573825005958	Leucine rich repeat; Region: LRR_8; pfam13855
573825005959	Leucine rich repeat; Region: LRR_8; pfam13855
573825005960	Leucine rich repeat; Region: LRR_8; pfam13855
573825005961	Leucine rich repeat; Region: LRR_8; pfam13855
573825005962	Leucine rich repeat; Region: LRR_8; pfam13855
573825005963	Leucine rich repeat; Region: LRR_8; pfam13855
573825005964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
573825005965	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825005966	cyclase homology domain; Region: CHD; cd07302
573825005967	nucleotidyl binding site; other site
573825005968	metal binding site [ion binding]; metal-binding site
573825005969	dimer interface [polypeptide binding]; other site
573825005970	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
573825005971	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825005972	active site
573825005973	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
573825005974	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
573825005975	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
573825005976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825005977	Stage II sporulation protein; Region: SpoIID; pfam08486
573825005978	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
573825005979	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
573825005980	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
573825005981	Walker A/P-loop; other site
573825005982	ATP binding site [chemical binding]; other site
573825005983	Q-loop/lid; other site
573825005984	ABC transporter signature motif; other site
573825005985	Walker B; other site
573825005986	D-loop; other site
573825005987	H-loop/switch region; other site
573825005988	FtsX-like permease family; Region: FtsX; pfam02687
573825005989	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
573825005990	FtsX-like permease family; Region: FtsX; pfam02687
573825005991	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825005992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825005993	active site
573825005994	NAD+ synthase (glutamine-hydrolysing); Region: PLN02339
573825005995	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
573825005996	multimer interface [polypeptide binding]; other site
573825005997	active site
573825005998	catalytic triad [active]
573825005999	protein interface 1 [polypeptide binding]; other site
573825006000	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
573825006001	homodimer interface [polypeptide binding]; other site
573825006002	NAD binding pocket [chemical binding]; other site
573825006003	ATP binding pocket [chemical binding]; other site
573825006004	Mg binding site [ion binding]; other site
573825006005	active-site loop [active]
573825006006	Predicted methyltransferases [General function prediction only]; Region: COG0313
573825006007	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
573825006008	putative SAM binding site [chemical binding]; other site
573825006009	putative homodimer interface [polypeptide binding]; other site
573825006010	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
573825006011	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
573825006012	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
573825006013	active site
573825006014	NAD binding site [chemical binding]; other site
573825006015	metal binding site [ion binding]; metal-binding site
573825006016	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
573825006017	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
573825006018	active site
573825006019	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
573825006020	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
573825006021	DHH family; Region: DHH; pfam01368
573825006022	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
573825006023	DHHA1 domain; Region: DHHA1; pfam02272
573825006024	poly(A) polymerase; Region: pcnB; TIGR01942
573825006025	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
573825006026	active site
573825006027	NTP binding site [chemical binding]; other site
573825006028	metal binding triad [ion binding]; metal-binding site
573825006029	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
573825006030	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825006031	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825006032	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
573825006033	Methyltransferase domain; Region: Methyltransf_18; pfam12847
573825006034	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
573825006035	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
573825006036	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
573825006037	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
573825006038	Domain of unknown function (DUF389); Region: DUF389; pfam04087
573825006039	putative single-stranded DNA-binding protein; Region: PHA01740
573825006040	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
573825006041	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
573825006042	Repair protein; Region: Repair_PSII; pfam04536
573825006043	Repair protein; Region: Repair_PSII; pfam04536
573825006044	Protein of unknown function (DUF419); Region: DUF419; pfam04237
573825006045	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
573825006046	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006047	CARDB; Region: CARDB; pfam07705
573825006048	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825006049	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825006050	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
573825006051	Leucine-rich repeats; other site
573825006052	Substrate binding site [chemical binding]; other site
573825006053	Leucine rich repeat; Region: LRR_8; pfam13855
573825006054	Leucine rich repeat; Region: LRR_8; pfam13855
573825006055	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825006056	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825006057	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
573825006058	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825006059	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
573825006060	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825006061	Bacterial SH3 domain; Region: SH3_3; pfam08239
573825006062	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
573825006063	cyclase homology domain; Region: CHD; cd07302
573825006064	nucleotidyl binding site; other site
573825006065	metal binding site [ion binding]; metal-binding site
573825006066	dimer interface [polypeptide binding]; other site
573825006067	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825006068	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825006069	glutamate racemase; Provisional; Region: PRK00865
573825006070	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
573825006071	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825006072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825006073	homodimer interface [polypeptide binding]; other site
573825006074	catalytic residue [active]
573825006075	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
573825006076	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825006077	protein binding site [polypeptide binding]; other site
573825006078	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
573825006079	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
573825006080	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
573825006081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006082	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006085	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006086	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825006087	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825006088	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825006089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006090	TPR repeat; Region: TPR_11; pfam13414
573825006091	TPR motif; other site
573825006092	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825006093	anti sigma factor interaction site; other site
573825006094	regulatory phosphorylation site [posttranslational modification]; other site
573825006095	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
573825006096	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
573825006097	Ligand binding site; other site
573825006098	Putative Catalytic site; other site
573825006099	DXD motif; other site
573825006100	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
573825006101	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006102	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006103	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006104	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006105	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006106	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825006107	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
573825006108	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
573825006109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825006110	NAD(P) binding site [chemical binding]; other site
573825006111	active site
573825006112	adenylosuccinate lyase; Provisional; Region: PRK07492
573825006113	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
573825006114	tetramer interface [polypeptide binding]; other site
573825006115	active site
573825006116	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
573825006117	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
573825006118	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
573825006119	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
573825006120	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825006121	Zn2+ binding site [ion binding]; other site
573825006122	Mg2+ binding site [ion binding]; other site
573825006123	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
573825006124	synthetase active site [active]
573825006125	NTP binding site [chemical binding]; other site
573825006126	metal binding site [ion binding]; metal-binding site
573825006127	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
573825006128	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
573825006129	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
573825006130	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
573825006131	dimerization interface [polypeptide binding]; other site
573825006132	active site
573825006133	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825006134	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825006135	ferric uptake regulator; Provisional; Region: fur; PRK09462
573825006136	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
573825006137	metal binding site 2 [ion binding]; metal-binding site
573825006138	putative DNA binding helix; other site
573825006139	metal binding site 1 [ion binding]; metal-binding site
573825006140	dimer interface [polypeptide binding]; other site
573825006141	structural Zn2+ binding site [ion binding]; other site
573825006142	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
573825006143	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
573825006144	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825006145	anti sigma factor interaction site; other site
573825006146	regulatory phosphorylation site [posttranslational modification]; other site
573825006147	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
573825006148	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825006149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006150	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006151	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006153	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825006154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825006155	S-adenosylmethionine binding site [chemical binding]; other site
573825006156	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
573825006157	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
573825006158	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825006159	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825006160	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
573825006161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825006162	active site
573825006163	phosphorylation site [posttranslational modification]
573825006164	intermolecular recognition site; other site
573825006165	dimerization interface [polypeptide binding]; other site
573825006166	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
573825006167	DNA binding site [nucleotide binding]
573825006168	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
573825006169	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
573825006170	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
573825006171	Ligand Binding Site [chemical binding]; other site
573825006172	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
573825006173	GAF domain; Region: GAF_3; pfam13492
573825006174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825006175	dimer interface [polypeptide binding]; other site
573825006176	phosphorylation site [posttranslational modification]
573825006177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825006178	ATP binding site [chemical binding]; other site
573825006179	Mg2+ binding site [ion binding]; other site
573825006180	G-X-G motif; other site
573825006181	K+-transporting ATPase, c chain; Region: KdpC; cl00944
573825006182	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
573825006183	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
573825006184	Soluble P-type ATPase [General function prediction only]; Region: COG4087
573825006185	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
573825006186	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
573825006187	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
573825006188	activation loop (A-loop); other site
573825006189	AAA ATPase domain; Region: AAA_16; pfam13191
573825006190	Predicted ATPase [General function prediction only]; Region: COG3899
573825006191	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825006192	GAF domain; Region: GAF; pfam01590
573825006193	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825006194	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825006195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825006196	Uncharacterized conserved protein [Function unknown]; Region: COG3349
573825006197	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
573825006198	Uncharacterized conserved protein [Function unknown]; Region: COG1262
573825006199	Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246
573825006200	active site
573825006201	Zn binding site [ion binding]; other site
573825006202	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
573825006203	EamA-like transporter family; Region: EamA; pfam00892
573825006204	EamA-like transporter family; Region: EamA; pfam00892
573825006205	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
573825006206	bile acid transporter; Region: bass; TIGR00841
573825006207	Sodium Bile acid symporter family; Region: SBF; cl17470
573825006208	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
573825006209	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
573825006210	active site residue [active]
573825006211	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825006212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825006213	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
573825006214	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
573825006215	dimer interface [polypeptide binding]; other site
573825006216	active site
573825006217	Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389
573825006218	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
573825006219	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825006220	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825006221	active site
573825006222	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
573825006223	CoA-transferase family III; Region: CoA_transf_3; pfam02515
573825006224	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
573825006225	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
573825006226	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825006227	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
573825006228	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
573825006229	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
573825006230	N-terminal plug; other site
573825006231	ligand-binding site [chemical binding]; other site
573825006232	putative DNA polymerase catalytic subunit; Provisional; Region: PHA03334
573825006233	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825006234	DDE superfamily endonuclease; Region: DDE_4; pfam13359
573825006235	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
573825006236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
573825006237	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
573825006238	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
573825006239	putative NAD(P) binding site [chemical binding]; other site
573825006240	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
573825006241	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
573825006242	MORN repeat; Region: MORN; cl14787
573825006243	phosphodiesterase YaeI; Provisional; Region: PRK11340
573825006244	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
573825006245	putative active site [active]
573825006246	putative metal binding site [ion binding]; other site
573825006247	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006248	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006249	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006250	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825006251	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825006252	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825006253	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825006254	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825006255	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825006256	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
573825006257	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
573825006258	active site
573825006259	catalytic tetrad [active]
573825006260	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
573825006261	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825006262	ABC transporter; Region: ABC_tran_2; pfam12848
573825006263	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825006264	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
573825006265	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
573825006266	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
573825006267	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703
573825006268	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
573825006269	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
573825006270	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
573825006271	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09713
573825006272	CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cd09714
573825006273	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
573825006274	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687
573825006275	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688
573825006276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006277	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006278	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006279	Uncharacterized conserved protein [Function unknown]; Region: COG4933
573825006280	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
573825006281	HsdM N-terminal domain; Region: HsdM_N; pfam12161
573825006282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825006283	S-adenosylmethionine binding site [chemical binding]; other site
573825006284	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
573825006285	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
573825006286	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
573825006287	AAA domain; Region: AAA_13; pfam13166
573825006288	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
573825006289	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
573825006290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825006291	ATP binding site [chemical binding]; other site
573825006292	putative Mg++ binding site [ion binding]; other site
573825006293	Pectinacetylesterase; Region: PAE; pfam03283
573825006294	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006295	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006296	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006297	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006298	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
573825006299	Response regulator receiver domain; Region: Response_reg; pfam00072
573825006300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825006301	active site
573825006302	phosphorylation site [posttranslational modification]
573825006303	intermolecular recognition site; other site
573825006304	dimerization interface [polypeptide binding]; other site
573825006305	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825006306	dimerization interface [polypeptide binding]; other site
573825006307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825006308	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
573825006309	putative active site [active]
573825006310	heme pocket [chemical binding]; other site
573825006311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825006312	putative active site [active]
573825006313	heme pocket [chemical binding]; other site
573825006314	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825006315	dimer interface [polypeptide binding]; other site
573825006316	phosphorylation site [posttranslational modification]
573825006317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825006318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825006319	ATP binding site [chemical binding]; other site
573825006320	Mg2+ binding site [ion binding]; other site
573825006321	G-X-G motif; other site
573825006322	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
573825006323	putative hydrophobic ligand binding site [chemical binding]; other site
573825006324	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
573825006325	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
573825006326	substrate binding pocket [chemical binding]; other site
573825006327	chain length determination region; other site
573825006328	substrate-Mg2+ binding site; other site
573825006329	catalytic residues [active]
573825006330	aspartate-rich region 1; other site
573825006331	active site lid residues [active]
573825006332	aspartate-rich region 2; other site
573825006333	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
573825006334	transketolase; Reviewed; Region: PRK05899
573825006335	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
573825006336	TPP-binding site [chemical binding]; other site
573825006337	dimer interface [polypeptide binding]; other site
573825006338	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
573825006339	FecR protein; Region: FecR; pfam04773
573825006340	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825006341	dimerization interface [polypeptide binding]; other site
573825006342	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825006343	cyclase homology domain; Region: CHD; cd07302
573825006344	nucleotidyl binding site; other site
573825006345	metal binding site [ion binding]; metal-binding site
573825006346	dimer interface [polypeptide binding]; other site
573825006347	Cna protein B-type domain; Region: Cna_B_2; pfam13715
573825006348	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
573825006349	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825006350	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
573825006351	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825006352	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
573825006353	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
573825006354	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
573825006355	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
573825006356	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
573825006357	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
573825006358	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
573825006359	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825006360	Cytochrome c; Region: Cytochrom_C; pfam00034
573825006361	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
573825006362	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
573825006363	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
573825006364	The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764
573825006365	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
573825006366	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
573825006367	4Fe-4S binding domain; Region: Fer4_2; pfam12797
573825006368	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
573825006369	heme-binding residues [chemical binding]; other site
573825006370	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
573825006371	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825006372	Beta-propeller repeat; Region: SBBP; pfam06739
573825006373	Beta-propeller repeat; Region: SBBP; pfam06739
573825006374	Beta-propeller repeat; Region: SBBP; pfam06739
573825006375	Beta-propeller repeat; Region: SBBP; pfam06739
573825006376	Beta-propeller repeat; Region: SBBP; pfam06739
573825006377	Beta-propeller repeat; Region: SBBP; pfam06739
573825006378	Beta-propeller repeat; Region: SBBP; pfam06739
573825006379	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
573825006380	putative active site [active]
573825006381	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
573825006382	Uncharacterized conserved protein [Function unknown]; Region: COG1262
573825006383	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006385	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006386	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006388	binding surface
573825006389	TPR motif; other site
573825006390	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
573825006391	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
573825006392	TPP-binding site; other site
573825006393	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
573825006394	PYR/PP interface [polypeptide binding]; other site
573825006395	dimer interface [polypeptide binding]; other site
573825006396	TPP binding site [chemical binding]; other site
573825006397	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
573825006398	CHASE2 domain; Region: CHASE2; pfam05226
573825006399	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825006400	cyclase homology domain; Region: CHD; cd07302
573825006401	nucleotidyl binding site; other site
573825006402	metal binding site [ion binding]; metal-binding site
573825006403	dimer interface [polypeptide binding]; other site
573825006404	potential protein location (hypothetical protein) that overlaps protein (adenylate cyclase-related protein)
573825006405	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825006406	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
573825006407	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
573825006408	substrate binding site [chemical binding]; other site
573825006409	active site
573825006410	catalytic residues [active]
573825006411	heterodimer interface [polypeptide binding]; other site
573825006412	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
573825006413	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
573825006414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825006415	catalytic residue [active]
573825006416	prolyl-tRNA synthetase; Provisional; Region: PRK09194
573825006417	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
573825006418	dimer interface [polypeptide binding]; other site
573825006419	motif 1; other site
573825006420	active site
573825006421	motif 2; other site
573825006422	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
573825006423	putative deacylase active site [active]
573825006424	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
573825006425	active site
573825006426	motif 3; other site
573825006427	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
573825006428	anticodon binding site; other site
573825006429	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
573825006430	active site
573825006431	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
573825006432	RIP metalloprotease RseP; Region: TIGR00054
573825006433	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825006434	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
573825006435	putative substrate binding region [chemical binding]; other site
573825006436	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
573825006437	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
573825006438	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
573825006439	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
573825006440	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
573825006441	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
573825006442	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14842
573825006443	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
573825006444	catalytic residue [active]
573825006445	putative FPP diphosphate  binding site; other site
573825006446	putative FPP binding hydrophobic cleft; other site
573825006447	dimer interface [polypeptide binding]; other site
573825006448	putative IPP diphosphate binding site; other site
573825006449	ribosome recycling factor; Reviewed; Region: frr; PRK00083
573825006450	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
573825006451	hinge region; other site
573825006452	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
573825006453	putative nucleotide binding site [chemical binding]; other site
573825006454	uridine monophosphate binding site [chemical binding]; other site
573825006455	homohexameric interface [polypeptide binding]; other site
573825006456	elongation factor Ts; Reviewed; Region: tsf; PRK12332
573825006457	UBA/TS-N domain; Region: UBA; pfam00627
573825006458	Elongation factor TS; Region: EF_TS; pfam00889
573825006459	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
573825006460	rRNA interaction site [nucleotide binding]; other site
573825006461	S8 interaction site; other site
573825006462	putative laminin-1 binding site; other site
573825006463	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
573825006464	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
573825006465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006466	TPR repeat; Region: TPR_11; pfam13414
573825006467	binding surface
573825006468	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
573825006469	TIGR00159 family protein; Region: TIGR00159
573825006470	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
573825006471	dihydrodipicolinate reductase; Provisional; Region: PRK00048
573825006472	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
573825006473	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
573825006474	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
573825006475	dihydrodipicolinate synthase; Region: dapA; TIGR00674
573825006476	dimer interface [polypeptide binding]; other site
573825006477	active site
573825006478	catalytic residue [active]
573825006479	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
573825006480	Mg++ binding site [ion binding]; other site
573825006481	putative catalytic motif [active]
573825006482	putative substrate binding site [chemical binding]; other site
573825006483	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825006484	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
573825006485	active site
573825006486	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
573825006487	TIGR01777 family protein; Region: yfcH
573825006488	putative NAD(P) binding site [chemical binding]; other site
573825006489	putative active site [active]
573825006490	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
573825006491	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825006492	RibD C-terminal domain; Region: RibD_C; cl17279
573825006493	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
573825006494	dimer interface [polypeptide binding]; other site
573825006495	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825006496	Leucine-rich repeats; other site
573825006497	Leucine rich repeat; Region: LRR_8; pfam13855
573825006498	Substrate binding site [chemical binding]; other site
573825006499	Leucine rich repeat; Region: LRR_8; pfam13855
573825006500	Leucine rich repeat; Region: LRR_8; pfam13855
573825006501	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
573825006502	Leucine rich repeat; Region: LRR_8; pfam13855
573825006503	Leucine rich repeat; Region: LRR_8; pfam13855
573825006504	Leucine rich repeat; Region: LRR_8; pfam13855
573825006505	Leucine rich repeat; Region: LRR_8; pfam13855
573825006506	Leucine rich repeat; Region: LRR_8; pfam13855
573825006507	Leucine rich repeat; Region: LRR_8; pfam13855
573825006508	Leucine rich repeat; Region: LRR_8; pfam13855
573825006509	Leucine rich repeat; Region: LRR_8; pfam13855
573825006510	Leucine rich repeat; Region: LRR_8; pfam13855
573825006511	Leucine rich repeat; Region: LRR_8; pfam13855
573825006512	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
573825006513	Leucine-rich repeats; other site
573825006514	Substrate binding site [chemical binding]; other site
573825006515	Leucine rich repeat; Region: LRR_8; pfam13855
573825006516	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
573825006517	putative transposase OrfB; Reviewed; Region: PHA02517
573825006518	Integrase core domain; Region: rve; pfam00665
573825006519	Integrase core domain; Region: rve_3; pfam13683
573825006520	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
573825006521	Kelch domain; Region: Kelch; smart00612
573825006522	DNA packaging tegument protein UL25; Provisional; Region: PHA03248
573825006523	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
573825006524	Family description; Region: VCBS; pfam13517
573825006525	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
573825006526	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
573825006527	RHS Repeat; Region: RHS_repeat; cl11982
573825006528	RHS Repeat; Region: RHS_repeat; pfam05593
573825006529	RHS Repeat; Region: RHS_repeat; pfam05593
573825006530	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
573825006531	Kelch motif; Region: Kelch_1; pfam01344
573825006532	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825006533	potential frameshift: common BLAST hit: gi|45656712|ref|YP_000798.1| lipoprotein
573825006534	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825006535	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825006536	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
573825006537	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
573825006538	catalytic residues [active]
573825006539	Uncharacterized conserved protein [Function unknown]; Region: COG1434
573825006540	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
573825006541	putative active site [active]
573825006542	CcmE; Region: CcmE; cl00994
573825006543	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
573825006544	Cytochrome C biogenesis protein; Region: CcmH; cl01179
573825006545	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
573825006546	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
573825006547	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
573825006548	putative NAD(P) binding site [chemical binding]; other site
573825006549	catalytic Zn binding site [ion binding]; other site
573825006550	structural Zn binding site [ion binding]; other site
573825006551	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
573825006552	CoenzymeA binding site [chemical binding]; other site
573825006553	subunit interaction site [polypeptide binding]; other site
573825006554	PHB binding site; other site
573825006555	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
573825006556	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
573825006557	C-terminal domain interface [polypeptide binding]; other site
573825006558	GSH binding site (G-site) [chemical binding]; other site
573825006559	dimer interface [polypeptide binding]; other site
573825006560	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
573825006561	N-terminal domain interface [polypeptide binding]; other site
573825006562	putative dimer interface [polypeptide binding]; other site
573825006563	active site
573825006564	potential protein location (hypothetical protein) that overlaps protein (glutathione transferase)
573825006565	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
573825006566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825006567	dimer interface [polypeptide binding]; other site
573825006568	phosphorylation site [posttranslational modification]
573825006569	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825006570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825006571	ATP binding site [chemical binding]; other site
573825006572	Mg2+ binding site [ion binding]; other site
573825006573	G-X-G motif; other site
573825006574	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825006575	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
573825006576	catalytic core [active]
573825006577	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
573825006578	putative active site [active]
573825006579	putative substrate binding site [chemical binding]; other site
573825006580	ATP binding site [chemical binding]; other site
573825006581	Phosphotransferase enzyme family; Region: APH; pfam01636
573825006582	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825006583	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825006584	active site
573825006585	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
573825006586	substrate binding site [chemical binding]; other site
573825006587	multimerization interface [polypeptide binding]; other site
573825006588	ATP binding site [chemical binding]; other site
573825006589	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
573825006590	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825006591	substrate binding site [chemical binding]; other site
573825006592	oxyanion hole (OAH) forming residues; other site
573825006593	trimer interface [polypeptide binding]; other site
573825006594	Cupin; Region: Cupin_6; pfam12852
573825006595	Uncharacterized conserved protein [Function unknown]; Region: COG3391
573825006596	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
573825006597	structural tetrad; other site
573825006598	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
573825006599	Acyltransferase family; Region: Acyl_transf_3; pfam01757
573825006600	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825006601	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825006602	ligand binding site [chemical binding]; other site
573825006603	flexible hinge region; other site
573825006604	transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720
573825006605	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
573825006606	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
573825006607	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
573825006608	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
573825006609	Protein of unknown function (DUF1563); Region: DUF1563; pfam07599
573825006610	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825006611	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
573825006612	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
573825006613	active site
573825006614	metal binding site [ion binding]; metal-binding site
573825006615	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
573825006616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
573825006617	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
573825006618	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
573825006619	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
573825006620	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
573825006621	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
573825006622	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
573825006623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
573825006624	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
573825006625	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
573825006626	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
573825006627	motif 1; other site
573825006628	active site
573825006629	motif 2; other site
573825006630	motif 3; other site
573825006631	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
573825006632	DHHA1 domain; Region: DHHA1; pfam02272
573825006633	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
573825006634	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
573825006635	23S rRNA interface [nucleotide binding]; other site
573825006636	L3 interface [polypeptide binding]; other site
573825006637	YceI-like domain; Region: YceI; pfam04264
573825006638	thiamine monophosphate kinase; Provisional; Region: PRK05731
573825006639	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
573825006640	ATP binding site [chemical binding]; other site
573825006641	dimerization interface [polypeptide binding]; other site
573825006642	30S ribosomal protein S7; Validated; Region: PRK05302
573825006643	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
573825006644	S17 interaction site [polypeptide binding]; other site
573825006645	S8 interaction site; other site
573825006646	16S rRNA interaction site [nucleotide binding]; other site
573825006647	streptomycin interaction site [chemical binding]; other site
573825006648	23S rRNA interaction site [nucleotide binding]; other site
573825006649	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
573825006650	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
573825006651	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
573825006652	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
573825006653	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
573825006654	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
573825006655	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
573825006656	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
573825006657	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
573825006658	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
573825006659	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
573825006660	DNA binding site [nucleotide binding]
573825006661	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
573825006662	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
573825006663	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
573825006664	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
573825006665	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
573825006666	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
573825006667	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
573825006668	RPB10 interaction site [polypeptide binding]; other site
573825006669	RPB1 interaction site [polypeptide binding]; other site
573825006670	RPB11 interaction site [polypeptide binding]; other site
573825006671	RPB3 interaction site [polypeptide binding]; other site
573825006672	RPB12 interaction site [polypeptide binding]; other site
573825006673	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
573825006674	core dimer interface [polypeptide binding]; other site
573825006675	peripheral dimer interface [polypeptide binding]; other site
573825006676	L10 interface [polypeptide binding]; other site
573825006677	L11 interface [polypeptide binding]; other site
573825006678	putative EF-Tu interaction site [polypeptide binding]; other site
573825006679	putative EF-G interaction site [polypeptide binding]; other site
573825006680	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
573825006681	23S rRNA interface [nucleotide binding]; other site
573825006682	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
573825006683	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
573825006684	mRNA/rRNA interface [nucleotide binding]; other site
573825006685	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
573825006686	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
573825006687	23S rRNA interface [nucleotide binding]; other site
573825006688	L7/L12 interface [polypeptide binding]; other site
573825006689	putative thiostrepton binding site; other site
573825006690	L25 interface [polypeptide binding]; other site
573825006691	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
573825006692	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
573825006693	putative homodimer interface [polypeptide binding]; other site
573825006694	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
573825006695	heterodimer interface [polypeptide binding]; other site
573825006696	homodimer interface [polypeptide binding]; other site
573825006697	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
573825006698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006699	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006700	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006702	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
573825006703	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
573825006704	active site
573825006705	metal binding site [ion binding]; metal-binding site
573825006706	helicase 45; Provisional; Region: PTZ00424
573825006707	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
573825006708	ATP binding site [chemical binding]; other site
573825006709	Mg++ binding site [ion binding]; other site
573825006710	motif III; other site
573825006711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825006712	nucleotide binding region [chemical binding]; other site
573825006713	ATP-binding site [chemical binding]; other site
573825006714	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825006715	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825006716	S-adenosylmethionine binding site [chemical binding]; other site
573825006717	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
573825006718	homotrimer interaction site [polypeptide binding]; other site
573825006719	putative active site [active]
573825006720	multifunctional aminopeptidase A; Provisional; Region: PRK00913
573825006721	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
573825006722	interface (dimer of trimers) [polypeptide binding]; other site
573825006723	Substrate-binding/catalytic site; other site
573825006724	Zn-binding sites [ion binding]; other site
573825006725	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
573825006726	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
573825006727	catalytic triad [active]
573825006728	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
573825006729	Beta-lactamase; Region: Beta-lactamase; pfam00144
573825006730	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
573825006731	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
573825006732	active site
573825006733	Riboflavin kinase; Region: Flavokinase; pfam01687
573825006734	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825006735	PAS domain S-box; Region: sensory_box; TIGR00229
573825006736	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825006737	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
573825006738	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
573825006739	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
573825006740	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
573825006741	amphipathic channel; other site
573825006742	Asn-Pro-Ala signature motifs; other site
573825006743	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825006744	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825006745	polyphosphate kinase; Provisional; Region: PRK05443
573825006746	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
573825006747	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
573825006748	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
573825006749	putative domain interface [polypeptide binding]; other site
573825006750	putative active site [active]
573825006751	catalytic site [active]
573825006752	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
573825006753	putative domain interface [polypeptide binding]; other site
573825006754	putative active site [active]
573825006755	catalytic site [active]
573825006756	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
573825006757	FAD binding domain; Region: FAD_binding_4; pfam01565
573825006758	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
573825006759	Predicted amidohydrolase [General function prediction only]; Region: COG0388
573825006760	putative active site [active]
573825006761	catalytic triad [active]
573825006762	putative dimer interface [polypeptide binding]; other site
573825006763	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
573825006764	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
573825006765	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
573825006766	active site
573825006767	Zn binding site [ion binding]; other site
573825006768	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
573825006769	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
573825006770	N-terminal plug; other site
573825006771	ligand-binding site [chemical binding]; other site
573825006772	Imelysin; Region: Peptidase_M75; pfam09375
573825006773	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
573825006774	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
573825006775	Imelysin; Region: Peptidase_M75; pfam09375
573825006776	DUF35 OB-fold domain; Region: DUF35; pfam01796
573825006777	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
573825006778	active site
573825006779	oxyanion hole [active]
573825006780	Transposase; Region: HTH_Tnp_1; pfam01527
573825006781	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825006782	putative transposase OrfB; Reviewed; Region: PHA02517
573825006783	Integrase core domain; Region: rve; pfam00665
573825006784	Integrase core domain; Region: rve_3; pfam13683
573825006785	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
573825006786	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
573825006787	NAD(P) binding site [chemical binding]; other site
573825006788	homotetramer interface [polypeptide binding]; other site
573825006789	homodimer interface [polypeptide binding]; other site
573825006790	active site
573825006791	Predicted esterase [General function prediction only]; Region: COG0400
573825006792	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
573825006793	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825006794	SPFH domain / Band 7 family; Region: Band_7; pfam01145
573825006795	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
573825006796	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
573825006797	PhoU domain; Region: PhoU; pfam01895
573825006798	PhoU domain; Region: PhoU; pfam01895
573825006799	MAPEG family; Region: MAPEG; pfam01124
573825006800	Ycf48-like protein; Provisional; Region: PRK13684
573825006801	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006802	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006803	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006804	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825006805	HAMP domain; Region: HAMP; pfam00672
573825006806	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825006807	dimer interface [polypeptide binding]; other site
573825006808	putative CheW interface [polypeptide binding]; other site
573825006809	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
573825006810	Cytochrome c; Region: Cytochrom_C; pfam00034
573825006811	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
573825006812	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
573825006813	Cytochrome c; Region: Cytochrom_C; pfam00034
573825006814	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
573825006815	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
573825006816	putative active site [active]
573825006817	catalytic triad [active]
573825006818	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
573825006819	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
573825006820	ATP binding site [chemical binding]; other site
573825006821	active site
573825006822	substrate binding site [chemical binding]; other site
573825006823	Response regulator receiver domain; Region: Response_reg; pfam00072
573825006824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825006825	active site
573825006826	phosphorylation site [posttranslational modification]
573825006827	intermolecular recognition site; other site
573825006828	dimerization interface [polypeptide binding]; other site
573825006829	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825006830	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
573825006831	CcmB protein; Region: CcmB; cl17444
573825006832	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
573825006833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825006834	Walker A/P-loop; other site
573825006835	ATP binding site [chemical binding]; other site
573825006836	Q-loop/lid; other site
573825006837	ABC transporter signature motif; other site
573825006838	Walker B; other site
573825006839	D-loop; other site
573825006840	H-loop/switch region; other site
573825006841	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006842	Protein of unknown function (DUF3286); Region: DUF3286; pfam11689
573825006843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006844	binding surface
573825006845	TPR motif; other site
573825006846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006847	binding surface
573825006848	TPR motif; other site
573825006849	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
573825006850	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
573825006851	Walker A/P-loop; other site
573825006852	ATP binding site [chemical binding]; other site
573825006853	Q-loop/lid; other site
573825006854	ABC transporter signature motif; other site
573825006855	Walker B; other site
573825006856	D-loop; other site
573825006857	H-loop/switch region; other site
573825006858	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
573825006859	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
573825006860	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
573825006861	Mrr N-terminal domain; Region: Mrr_N; pfam14338
573825006862	Restriction endonuclease; Region: Mrr_cat; pfam04471
573825006863	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825006864	active site
573825006865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
573825006866	dimerization interface [polypeptide binding]; other site
573825006867	putative DNA binding site [nucleotide binding]; other site
573825006868	putative Zn2+ binding site [ion binding]; other site
573825006869	DoxX-like family; Region: DoxX_2; pfam13564
573825006870	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
573825006871	hydrophobic ligand binding site; other site
573825006872	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
573825006873	putative hydrophobic ligand binding site [chemical binding]; other site
573825006874	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
573825006875	putative hydrophobic ligand binding site [chemical binding]; other site
573825006876	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
573825006877	putative hydrophobic ligand binding site [chemical binding]; other site
573825006878	RibD C-terminal domain; Region: RibD_C; cl17279
573825006879	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
573825006880	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
573825006881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825006882	putative substrate translocation pore; other site
573825006883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825006884	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
573825006885	putative catalytic site [active]
573825006886	metal binding site A [ion binding]; metal-binding site
573825006887	phosphate binding site [ion binding]; other site
573825006888	metal binding site C [ion binding]; metal-binding site
573825006889	metal binding site B [ion binding]; metal-binding site
573825006890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006891	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006892	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006893	Membrane protein of unknown function; Region: DUF360; pfam04020
573825006894	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
573825006895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825006896	S-adenosylmethionine binding site [chemical binding]; other site
573825006897	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
573825006898	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
573825006899	Uncharacterized conserved protein [Function unknown]; Region: COG4121
573825006900	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825006901	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
573825006902	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
573825006903	FMN binding site [chemical binding]; other site
573825006904	active site
573825006905	catalytic residues [active]
573825006906	substrate binding site [chemical binding]; other site
573825006907	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825006908	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825006909	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825006910	DNA binding residues [nucleotide binding]
573825006911	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825006912	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
573825006913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825006914	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825006915	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825006916	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
573825006917	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
573825006918	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
573825006919	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825006920	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
573825006921	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
573825006922	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
573825006923	trimerization site [polypeptide binding]; other site
573825006924	active site
573825006925	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
573825006926	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
573825006927	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825006928	catalytic residue [active]
573825006929	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
573825006930	[2Fe-2S] cluster binding site [ion binding]; other site
573825006931	FeS assembly protein SufD; Region: sufD; TIGR01981
573825006932	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
573825006933	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
573825006934	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
573825006935	Walker A/P-loop; other site
573825006936	ATP binding site [chemical binding]; other site
573825006937	Q-loop/lid; other site
573825006938	ABC transporter signature motif; other site
573825006939	Walker B; other site
573825006940	D-loop; other site
573825006941	H-loop/switch region; other site
573825006942	Protein required for attachment to host cells; Region: Host_attach; pfam10116
573825006943	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
573825006944	metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK5_metazoa; cd07793
573825006945	putative N- and C-terminal domain interface [polypeptide binding]; other site
573825006946	putative active site [active]
573825006947	putative MgATP binding site [chemical binding]; other site
573825006948	catalytic site [active]
573825006949	metal binding site [ion binding]; metal-binding site
573825006950	putative homotetramer interface [polypeptide binding]; other site
573825006951	putative homodimer interface [polypeptide binding]; other site
573825006952	putative glycerol binding site [chemical binding]; other site
573825006953	Cytochrome c; Region: Cytochrom_C; pfam00034
573825006954	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825006955	anti sigma factor interaction site; other site
573825006956	regulatory phosphorylation site [posttranslational modification]; other site
573825006957	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
573825006958	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
573825006959	Ligand binding site; other site
573825006960	oligomer interface; other site
573825006961	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
573825006962	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
573825006963	flagellar motor protein MotB; Validated; Region: motB; PRK06667
573825006964	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
573825006965	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825006966	ligand binding site [chemical binding]; other site
573825006967	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
573825006968	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
573825006969	Flagellar protein (FlbD); Region: FlbD; pfam06289
573825006970	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825006971	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
573825006972	putative ADP-binding pocket [chemical binding]; other site
573825006973	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
573825006974	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
573825006975	putative active site [active]
573825006976	metal binding site [ion binding]; metal-binding site
573825006977	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
573825006978	DNA protecting protein DprA; Region: dprA; TIGR00732
573825006979	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
573825006980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
573825006981	binding surface
573825006982	TPR motif; other site
573825006983	Predicted membrane protein [Function unknown]; Region: COG4270
573825006984	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
573825006985	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
573825006986	Coenzyme A binding pocket [chemical binding]; other site
573825006987	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
573825006988	homotrimer interaction site [polypeptide binding]; other site
573825006989	zinc binding site [ion binding]; other site
573825006990	CDP-binding sites; other site
573825006991	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825006992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825006993	TPR motif; other site
573825006994	binding surface
573825006995	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
573825006996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825006997	Walker A motif; other site
573825006998	ATP binding site [chemical binding]; other site
573825006999	Walker B motif; other site
573825007000	arginine finger; other site
573825007001	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
573825007002	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825007003	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825007004	inhibitor-cofactor binding pocket; inhibition site
573825007005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825007006	catalytic residue [active]
573825007007	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
573825007008	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
573825007009	dimerization interface [polypeptide binding]; other site
573825007010	DPS ferroxidase diiron center [ion binding]; other site
573825007011	ion pore; other site
573825007012	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
573825007013	hydrophobic ligand binding site; other site
573825007014	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
573825007015	Sulfatase; Region: Sulfatase; pfam00884
573825007016	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
573825007017	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825007018	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
573825007019	active site
573825007020	catalytic site [active]
573825007021	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
573825007022	active site
573825007023	catalytic site [active]
573825007024	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
573825007025	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
573825007026	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825007027	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825007028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007029	TPR motif; other site
573825007030	binding surface
573825007031	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825007032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007033	binding surface
573825007034	TPR motif; other site
573825007035	Protein of unknown function (DUF1562); Region: DUF1562; pfam07601
573825007036	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
573825007037	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
573825007038	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
573825007039	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825007040	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825007041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007042	binding surface
573825007043	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825007044	TPR motif; other site
573825007045	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825007046	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825007047	ligand binding site [chemical binding]; other site
573825007048	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
573825007049	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
573825007050	active site
573825007051	nucleophile elbow; other site
573825007052	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007054	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007055	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007056	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
573825007057	ammonium transporter; Region: amt; TIGR00836
573825007058	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
573825007059	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825007060	dimer interface [polypeptide binding]; other site
573825007061	putative CheW interface [polypeptide binding]; other site
573825007062	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
573825007063	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
573825007064	putative active site [active]
573825007065	putative dimer interface [polypeptide binding]; other site
573825007066	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
573825007067	putative ADP-binding pocket [chemical binding]; other site
573825007068	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825007069	DNA polymerase I; Provisional; Region: PRK05755
573825007070	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
573825007071	active site
573825007072	metal binding site 1 [ion binding]; metal-binding site
573825007073	putative 5' ssDNA interaction site; other site
573825007074	metal binding site 3; metal-binding site
573825007075	metal binding site 2 [ion binding]; metal-binding site
573825007076	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
573825007077	putative DNA binding site [nucleotide binding]; other site
573825007078	putative metal binding site [ion binding]; other site
573825007079	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
573825007080	active site
573825007081	catalytic site [active]
573825007082	substrate binding site [chemical binding]; other site
573825007083	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
573825007084	active site
573825007085	DNA binding site [nucleotide binding]
573825007086	catalytic site [active]
573825007087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825007088	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825007089	active site
573825007090	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
573825007091	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
573825007092	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
573825007093	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
573825007094	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
573825007095	glutamine binding [chemical binding]; other site
573825007096	catalytic triad [active]
573825007097	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
573825007098	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
573825007099	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
573825007100	Walker A/P-loop; other site
573825007101	ATP binding site [chemical binding]; other site
573825007102	Q-loop/lid; other site
573825007103	ABC transporter signature motif; other site
573825007104	Walker B; other site
573825007105	D-loop; other site
573825007106	H-loop/switch region; other site
573825007107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007108	active site
573825007109	phosphorylation site [posttranslational modification]
573825007110	intermolecular recognition site; other site
573825007111	HEAT repeats; Region: HEAT_2; pfam13646
573825007112	HEAT repeats; Region: HEAT_2; pfam13646
573825007113	HEAT repeats; Region: HEAT_2; pfam13646
573825007114	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
573825007115	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
573825007116	HflX GTPase family; Region: HflX; cd01878
573825007117	G1 box; other site
573825007118	GTP/Mg2+ binding site [chemical binding]; other site
573825007119	Switch I region; other site
573825007120	G2 box; other site
573825007121	G3 box; other site
573825007122	Switch II region; other site
573825007123	G4 box; other site
573825007124	G5 box; other site
573825007125	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
573825007126	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
573825007127	active site
573825007128	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
573825007129	homoserine dehydrogenase; Provisional; Region: PRK06349
573825007130	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
573825007131	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
573825007132	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
573825007133	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825007134	anti sigma factor interaction site; other site
573825007135	regulatory phosphorylation site [posttranslational modification]; other site
573825007136	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825007137	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
573825007138	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
573825007139	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
573825007140	substrate binding site [chemical binding]; other site
573825007141	oxyanion hole (OAH) forming residues; other site
573825007142	trimer interface [polypeptide binding]; other site
573825007143	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
573825007144	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
573825007145	dimer interface [polypeptide binding]; other site
573825007146	ssDNA binding site [nucleotide binding]; other site
573825007147	tetramer (dimer of dimers) interface [polypeptide binding]; other site
573825007148	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
573825007149	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
573825007150	Cu(I) binding site [ion binding]; other site
573825007151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
573825007152	YHYH protein; Region: YHYH; pfam14240
573825007153	RNA polymerase sigma factor; Provisional; Region: PRK11924
573825007154	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825007155	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
573825007156	DNA binding residues [nucleotide binding]
573825007157	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
573825007158	dimer interface [polypeptide binding]; other site
573825007159	Response regulator receiver domain; Region: Response_reg; pfam00072
573825007160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007161	active site
573825007162	phosphorylation site [posttranslational modification]
573825007163	intermolecular recognition site; other site
573825007164	dimerization interface [polypeptide binding]; other site
573825007165	SnoaL-like domain; Region: SnoaL_2; pfam12680
573825007166	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825007167	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
573825007168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825007169	dimer interface [polypeptide binding]; other site
573825007170	phosphorylation site [posttranslational modification]
573825007171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007172	ATP binding site [chemical binding]; other site
573825007173	Mg2+ binding site [ion binding]; other site
573825007174	G-X-G motif; other site
573825007175	Response regulator receiver domain; Region: Response_reg; pfam00072
573825007176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007177	active site
573825007178	phosphorylation site [posttranslational modification]
573825007179	intermolecular recognition site; other site
573825007180	dimerization interface [polypeptide binding]; other site
573825007181	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
573825007182	putative heme binding pocket [chemical binding]; other site
573825007183	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825007184	anti sigma factor interaction site; other site
573825007185	regulatory phosphorylation site [posttranslational modification]; other site
573825007186	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
573825007187	active site
573825007188	dimerization interface [polypeptide binding]; other site
573825007189	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
573825007190	Fe-S cluster binding site [ion binding]; other site
573825007191	active site
573825007192	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
573825007193	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
573825007194	methionine sulfoxide reductase A; Provisional; Region: PRK14054
573825007195	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
573825007196	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
573825007197	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825007198	FAD binding site [chemical binding]; other site
573825007199	substrate binding site [chemical binding]; other site
573825007200	catalytic residues [active]
573825007201	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
573825007202	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
573825007203	trimer interface [polypeptide binding]; other site
573825007204	active site
573825007205	substrate binding site [chemical binding]; other site
573825007206	CoA binding site [chemical binding]; other site
573825007207	Pathogenicity locus; Region: Cdd1; pfam11731
573825007208	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
573825007209	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825007210	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825007211	ABC transporter; Region: ABC_tran_2; pfam12848
573825007212	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
573825007213	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825007214	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
573825007215	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825007216	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825007217	ligand binding site [chemical binding]; other site
573825007218	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
573825007219	Protein of unknown function; Region: DUF3658; pfam12395
573825007220	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
573825007221	Protein of unknown function; Region: DUF3658; pfam12395
573825007222	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
573825007223	Transglycosylase; Region: Transgly; pfam00912
573825007224	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
573825007225	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
573825007226	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
573825007227	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
573825007228	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
573825007229	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
573825007230	Walker A/P-loop; other site
573825007231	ATP binding site [chemical binding]; other site
573825007232	Q-loop/lid; other site
573825007233	ABC transporter signature motif; other site
573825007234	Walker B; other site
573825007235	D-loop; other site
573825007236	H-loop/switch region; other site
573825007237	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
573825007238	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
573825007239	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
573825007240	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
573825007241	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
573825007242	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
573825007243	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
573825007244	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
573825007245	Low molecular weight phosphatase family; Region: LMWPc; cl00105
573825007246	active site
573825007247	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
573825007248	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
573825007249	GrpE; Region: GrpE; pfam01025
573825007250	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
573825007251	dimer interface [polypeptide binding]; other site
573825007252	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
573825007253	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
573825007254	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
573825007255	nucleotide binding site [chemical binding]; other site
573825007256	NEF interaction site [polypeptide binding]; other site
573825007257	SBD interface [polypeptide binding]; other site
573825007258	chaperone protein DnaJ; Provisional; Region: PRK14286
573825007259	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
573825007260	HSP70 interaction site [polypeptide binding]; other site
573825007261	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
573825007262	substrate binding site [polypeptide binding]; other site
573825007263	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
573825007264	Zn binding sites [ion binding]; other site
573825007265	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
573825007266	dimer interface [polypeptide binding]; other site
573825007267	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
573825007268	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
573825007269	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
573825007270	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
573825007271	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
573825007272	FtsX-like permease family; Region: FtsX; pfam02687
573825007273	FtsX-like permease family; Region: FtsX; pfam02687
573825007274	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
573825007275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
573825007276	Walker A/P-loop; other site
573825007277	ATP binding site [chemical binding]; other site
573825007278	Q-loop/lid; other site
573825007279	ABC transporter signature motif; other site
573825007280	Walker B; other site
573825007281	D-loop; other site
573825007282	H-loop/switch region; other site
573825007283	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
573825007284	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
573825007285	HIGH motif; other site
573825007286	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
573825007287	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
573825007288	active site
573825007289	KMSKS motif; other site
573825007290	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
573825007291	tRNA binding surface [nucleotide binding]; other site
573825007292	Integrase core domain; Region: rve; pfam00665
573825007293	Integrase core domain; Region: rve_3; pfam13683
573825007294	Geminivirus BL1 movement protein; Region: Gemini_BL1; pfam00845
573825007295	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
573825007296	thioester formation/cholesterol transfer; other site
573825007297	protein-splicing catalytic site; other site
573825007298	Catalytic site; other site
573825007299	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
573825007300	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
573825007301	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
573825007302	thioester formation/cholesterol transfer; other site
573825007303	protein-splicing catalytic site; other site
573825007304	Putative Ig domain; Region: He_PIG; pfam05345
573825007305	Putative Ig domain; Region: He_PIG; pfam05345
573825007306	Putative Ig domain; Region: He_PIG; pfam05345
573825007307	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825007308	Fn3 associated; Region: Fn3_assoc; pfam13287
573825007309	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007310	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825007311	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
573825007312	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825007313	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825007314	Outer membrane efflux protein; Region: OEP; pfam02321
573825007315	Outer membrane efflux protein; Region: OEP; pfam02321
573825007316	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007317	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007318	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825007319	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
573825007320	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
573825007321	HlyD family secretion protein; Region: HlyD_3; pfam13437
573825007322	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825007323	Protein export membrane protein; Region: SecD_SecF; cl14618
573825007324	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825007325	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825007326	MORN repeat; Region: MORN; pfam02493
573825007327	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
573825007328	threonine synthase; Validated; Region: PRK06260
573825007329	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
573825007330	homodimer interface [polypeptide binding]; other site
573825007331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825007332	catalytic residue [active]
573825007333	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
573825007334	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
573825007335	Short C-terminal domain; Region: SHOCT; pfam09851
573825007336	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
573825007337	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
573825007338	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
573825007339	Catalytic site [active]
573825007340	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
573825007341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
573825007342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
573825007343	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
573825007344	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
573825007345	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
573825007346	active site
573825007347	HIGH motif; other site
573825007348	nucleotide binding site [chemical binding]; other site
573825007349	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
573825007350	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
573825007351	active site
573825007352	KMSKS motif; other site
573825007353	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
573825007354	tRNA binding surface [nucleotide binding]; other site
573825007355	anticodon binding site; other site
573825007356	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
573825007357	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13789
573825007358	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
573825007359	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
573825007360	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
573825007361	peptide chain release factor 2; Validated; Region: prfB; PRK00578
573825007362	PCRF domain; Region: PCRF; pfam03462
573825007363	RF-1 domain; Region: RF-1; pfam00472
573825007364	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
573825007365	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
573825007366	Transposase; Region: HTH_Tnp_1; pfam01527
573825007367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825007368	putative transposase OrfB; Reviewed; Region: PHA02517
573825007369	Integrase core domain; Region: rve; pfam00665
573825007370	Integrase core domain; Region: rve_3; pfam13683
573825007371	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
573825007372	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
573825007373	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007374	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007375	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007376	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007377	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007378	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
573825007379	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
573825007380	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
573825007381	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
573825007382	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
573825007383	active site
573825007384	purine riboside binding site [chemical binding]; other site
573825007385	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
573825007386	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
573825007387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
573825007388	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
573825007389	Ligand binding site; other site
573825007390	Putative Catalytic site; other site
573825007391	DXD motif; other site
573825007392	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
573825007393	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
573825007394	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
573825007395	active site
573825007396	substrate binding site [chemical binding]; other site
573825007397	metal binding site [ion binding]; metal-binding site
573825007398	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
573825007399	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
573825007400	glutaminase active site [active]
573825007401	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
573825007402	dimer interface [polypeptide binding]; other site
573825007403	active site
573825007404	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
573825007405	dimer interface [polypeptide binding]; other site
573825007406	active site
573825007407	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
573825007408	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
573825007409	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
573825007410	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
573825007411	Protein of unknown function (DUF1567); Region: DUF1567; pfam07604
573825007412	Protein of unknown function (DUF1567); Region: DUF1567; pfam07604
573825007413	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
573825007414	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
573825007415	Nitrogen regulatory protein P-II; Region: P-II; smart00938
573825007416	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
573825007417	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
573825007418	spermidine synthase; Provisional; Region: PRK03612
573825007419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825007420	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
573825007421	EVE domain; Region: EVE; cl00728
573825007422	FtsH Extracellular; Region: FtsH_ext; pfam06480
573825007423	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
573825007424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825007425	Walker A motif; other site
573825007426	ATP binding site [chemical binding]; other site
573825007427	Walker B motif; other site
573825007428	arginine finger; other site
573825007429	Peptidase family M41; Region: Peptidase_M41; pfam01434
573825007430	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
573825007431	putative active site [active]
573825007432	catalytic residue [active]
573825007433	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
573825007434	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
573825007435	5S rRNA interface [nucleotide binding]; other site
573825007436	CTC domain interface [polypeptide binding]; other site
573825007437	L16 interface [polypeptide binding]; other site
573825007438	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
573825007439	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
573825007440	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825007441	active site
573825007442	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
573825007443	Substrate binding site; other site
573825007444	Mg++ binding site; other site
573825007445	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14613
573825007446	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
573825007447	Predicted transcriptional regulator [Transcription]; Region: COG2378
573825007448	WYL domain; Region: WYL; pfam13280
573825007449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007450	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007451	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007452	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
573825007453	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
573825007454	Beta-propeller repeat; Region: SBBP; pfam06739
573825007455	Beta-propeller repeat; Region: SBBP; pfam06739
573825007456	Beta-propeller repeat; Region: SBBP; pfam06739
573825007457	Beta-propeller repeat; Region: SBBP; pfam06739
573825007458	Beta-propeller repeat; Region: SBBP; pfam06739
573825007459	PQQ-like domain; Region: PQQ_2; pfam13360
573825007460	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
573825007461	substrate binding site [chemical binding]; other site
573825007462	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
573825007463	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825007464	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825007465	cyclase homology domain; Region: CHD; cd07302
573825007466	nucleotidyl binding site; other site
573825007467	metal binding site [ion binding]; metal-binding site
573825007468	dimer interface [polypeptide binding]; other site
573825007469	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825007470	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825007471	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
573825007472	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825007473	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
573825007474	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
573825007475	catalytic site [active]
573825007476	Predicted membrane protein [Function unknown]; Region: COG2259
573825007477	Pirin-related protein [General function prediction only]; Region: COG1741
573825007478	Pirin; Region: Pirin; pfam02678
573825007479	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
573825007480	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
573825007481	hydrophobic ligand binding site; other site
573825007482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825007483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825007484	dimer interface [polypeptide binding]; other site
573825007485	phosphorylation site [posttranslational modification]
573825007486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007487	ATP binding site [chemical binding]; other site
573825007488	Mg2+ binding site [ion binding]; other site
573825007489	G-X-G motif; other site
573825007490	Response regulator receiver domain; Region: Response_reg; pfam00072
573825007491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007492	active site
573825007493	phosphorylation site [posttranslational modification]
573825007494	intermolecular recognition site; other site
573825007495	dimerization interface [polypeptide binding]; other site
573825007496	Sporulation related domain; Region: SPOR; pfam05036
573825007497	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
573825007498	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
573825007499	CoA-binding site [chemical binding]; other site
573825007500	ATP-binding [chemical binding]; other site
573825007501	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
573825007502	Histidine kinase; Region: HisKA_3; pfam07730
573825007503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007504	ATP binding site [chemical binding]; other site
573825007505	Mg2+ binding site [ion binding]; other site
573825007506	G-X-G motif; other site
573825007507	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
573825007508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007509	active site
573825007510	phosphorylation site [posttranslational modification]
573825007511	intermolecular recognition site; other site
573825007512	dimerization interface [polypeptide binding]; other site
573825007513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
573825007514	DNA binding residues [nucleotide binding]
573825007515	dimerization interface [polypeptide binding]; other site
573825007516	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825007517	Protein export membrane protein; Region: SecD_SecF; cl14618
573825007518	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
573825007519	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
573825007520	tandem repeat interface [polypeptide binding]; other site
573825007521	oligomer interface [polypeptide binding]; other site
573825007522	active site residues [active]
573825007523	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
573825007524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007525	binding surface
573825007526	TPR motif; other site
573825007527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007528	binding surface
573825007529	TPR motif; other site
573825007530	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
573825007531	TIGR01777 family protein; Region: yfcH
573825007532	putative NAD(P) binding site [chemical binding]; other site
573825007533	putative active site [active]
573825007534	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007535	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007536	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007537	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007538	Bacterial Ig-like domain; Region: Big_5; pfam13205
573825007539	Family description; Region: VCBS; pfam13517
573825007540	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
573825007541	FG-GAP repeat; Region: FG-GAP; pfam01839
573825007542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007543	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007544	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007545	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
573825007546	ligand binding site [chemical binding]; other site
573825007547	active site
573825007548	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825007549	anti sigma factor interaction site; other site
573825007550	regulatory phosphorylation site [posttranslational modification]; other site
573825007551	galactokinase; Provisional; Region: PRK05322
573825007552	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
573825007553	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
573825007554	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
573825007555	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
573825007556	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
573825007557	active site
573825007558	dimer interface [polypeptide binding]; other site
573825007559	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
573825007560	dimer interface [polypeptide binding]; other site
573825007561	active site
573825007562	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
573825007563	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
573825007564	Substrate binding site; other site
573825007565	metal-binding site
573825007566	Phosphotransferase enzyme family; Region: APH; pfam01636
573825007567	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
573825007568	substrate binding site [chemical binding]; other site
573825007569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007570	active site
573825007571	phosphorylation site [posttranslational modification]
573825007572	intermolecular recognition site; other site
573825007573	dimerization interface [polypeptide binding]; other site
573825007574	PAS domain; Region: PAS; smart00091
573825007575	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
573825007576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
573825007577	dimer interface [polypeptide binding]; other site
573825007578	phosphorylation site [posttranslational modification]
573825007579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007580	ATP binding site [chemical binding]; other site
573825007581	G-X-G motif; other site
573825007582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825007583	PAS domain; Region: PAS_9; pfam13426
573825007584	putative active site [active]
573825007585	heme pocket [chemical binding]; other site
573825007586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825007587	PAS domain; Region: PAS_9; pfam13426
573825007588	putative active site [active]
573825007589	heme pocket [chemical binding]; other site
573825007590	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
573825007591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825007592	dimer interface [polypeptide binding]; other site
573825007593	phosphorylation site [posttranslational modification]
573825007594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007595	ATP binding site [chemical binding]; other site
573825007596	Mg2+ binding site [ion binding]; other site
573825007597	G-X-G motif; other site
573825007598	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825007599	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007600	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007601	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007603	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007604	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
573825007605	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
573825007606	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
573825007607	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
573825007608	inhibitor-cofactor binding pocket; inhibition site
573825007609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825007610	catalytic residue [active]
573825007611	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825007612	metal binding site [ion binding]; metal-binding site
573825007613	active site
573825007614	I-site; other site
573825007615	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825007616	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
573825007617	HEAT repeats; Region: HEAT_2; pfam13646
573825007618	HEAT repeats; Region: HEAT_2; pfam13646
573825007619	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
573825007620	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825007621	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825007622	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
573825007623	tellurium resistance terB-like protein; Region: terB_like; cl11965
573825007624	metal binding site [ion binding]; metal-binding site
573825007625	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
573825007626	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
573825007627	active site
573825007628	HIGH motif; other site
573825007629	KMSKS motif; other site
573825007630	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
573825007631	tRNA binding surface [nucleotide binding]; other site
573825007632	anticodon binding site; other site
573825007633	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
573825007634	dimer interface [polypeptide binding]; other site
573825007635	putative tRNA-binding site [nucleotide binding]; other site
573825007636	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
573825007637	UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844
573825007638	metal binding triad; other site
573825007639	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
573825007640	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
573825007641	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825007642	Zn2+ binding site [ion binding]; other site
573825007643	Mg2+ binding site [ion binding]; other site
573825007644	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
573825007645	YceI-like domain; Region: YceI; pfam04264
573825007646	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
573825007647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825007648	NAD(P) binding site [chemical binding]; other site
573825007649	active site
573825007650	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
573825007651	Outer membrane efflux protein; Region: OEP; pfam02321
573825007652	Outer membrane efflux protein; Region: OEP; pfam02321
573825007653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825007654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825007655	active site
573825007656	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825007657	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825007658	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825007659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825007660	metal binding site [ion binding]; metal-binding site
573825007661	active site
573825007662	I-site; other site
573825007663	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
573825007664	FAD binding domain; Region: FAD_binding_4; pfam01565
573825007665	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
573825007666	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
573825007667	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
573825007668	Flavoprotein; Region: Flavoprotein; pfam02441
573825007669	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
573825007670	Domain of unknown function DUF21; Region: DUF21; pfam01595
573825007671	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
573825007672	Transporter associated domain; Region: CorC_HlyC; smart01091
573825007673	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
573825007674	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
573825007675	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
573825007676	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
573825007677	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
573825007678	active site
573825007679	metal binding site [ion binding]; metal-binding site
573825007680	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
573825007681	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
573825007682	generic binding surface II; other site
573825007683	ssDNA binding site; other site
573825007684	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825007685	ATP binding site [chemical binding]; other site
573825007686	putative Mg++ binding site [ion binding]; other site
573825007687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825007688	nucleotide binding region [chemical binding]; other site
573825007689	ATP-binding site [chemical binding]; other site
573825007690	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
573825007691	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
573825007692	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
573825007693	NAD binding site [chemical binding]; other site
573825007694	homodimer interface [polypeptide binding]; other site
573825007695	active site
573825007696	substrate binding site [chemical binding]; other site
573825007697	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
573825007698	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
573825007699	active site
573825007700	Hpt domain; Region: Hpt; pfam01627
573825007701	putative binding surface; other site
573825007702	active site
573825007703	Fic family protein [Function unknown]; Region: COG3177
573825007704	Fic/DOC family; Region: Fic; pfam02661
573825007705	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007706	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007707	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007709	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007710	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007711	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007712	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
573825007713	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
573825007714	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
573825007715	active site
573825007716	oligomerization interface [polypeptide binding]; other site
573825007717	metal binding site [ion binding]; metal-binding site
573825007718	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
573825007719	catalytic center binding site [active]
573825007720	ATP binding site [chemical binding]; other site
573825007721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825007722	Walker A motif; other site
573825007723	ATP binding site [chemical binding]; other site
573825007724	Walker B motif; other site
573825007725	arginine finger; other site
573825007726	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
573825007727	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
573825007728	NADP-binding site; other site
573825007729	homotetramer interface [polypeptide binding]; other site
573825007730	substrate binding site [chemical binding]; other site
573825007731	homodimer interface [polypeptide binding]; other site
573825007732	active site
573825007733	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
573825007734	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
573825007735	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825007736	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
573825007737	active site
573825007738	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
573825007739	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
573825007740	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
573825007741	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
573825007742	TrkA-N domain; Region: TrkA_N; pfam02254
573825007743	TrkA-C domain; Region: TrkA_C; pfam02080
573825007744	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
573825007745	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
573825007746	active site
573825007747	catalytic tetrad [active]
573825007748	Acylphosphatase; Region: Acylphosphatase; pfam00708
573825007749	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
573825007750	apolar tunnel; other site
573825007751	heme binding site [chemical binding]; other site
573825007752	dimerization interface [polypeptide binding]; other site
573825007753	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
573825007754	putative active site [active]
573825007755	Ap4A binding site [chemical binding]; other site
573825007756	nudix motif; other site
573825007757	putative metal binding site [ion binding]; other site
573825007758	SET domain; Region: SET; pfam00856
573825007759	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
573825007760	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
573825007761	active site
573825007762	catalytic site [active]
573825007763	metal binding site [ion binding]; metal-binding site
573825007764	dimer interface [polypeptide binding]; other site
573825007765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007766	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007767	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007768	MltA specific insert domain; Region: MltA; pfam03562
573825007769	3D domain; Region: 3D; pfam06725
573825007770	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
573825007771	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825007772	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825007773	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557
573825007774	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
573825007775	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
573825007776	TrkA-C domain; Region: TrkA_C; pfam02080
573825007777	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
573825007778	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
573825007779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
573825007780	Coenzyme A binding pocket [chemical binding]; other site
573825007781	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
573825007782	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
573825007783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825007784	FeS/SAM binding site; other site
573825007785	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
573825007786	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825007787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825007788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825007789	dimer interface [polypeptide binding]; other site
573825007790	phosphorylation site [posttranslational modification]
573825007791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825007792	ATP binding site [chemical binding]; other site
573825007793	Mg2+ binding site [ion binding]; other site
573825007794	G-X-G motif; other site
573825007795	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825007796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007797	active site
573825007798	phosphorylation site [posttranslational modification]
573825007799	intermolecular recognition site; other site
573825007800	dimerization interface [polypeptide binding]; other site
573825007801	GTPase RsgA; Reviewed; Region: PRK01889
573825007802	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
573825007803	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
573825007804	GTPase/Zn-binding domain interface [polypeptide binding]; other site
573825007805	GTP/Mg2+ binding site [chemical binding]; other site
573825007806	G4 box; other site
573825007807	G5 box; other site
573825007808	G1 box; other site
573825007809	Switch I region; other site
573825007810	G2 box; other site
573825007811	G3 box; other site
573825007812	Switch II region; other site
573825007813	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
573825007814	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
573825007815	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
573825007816	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
573825007817	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
573825007818	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
573825007819	Methyltransferase domain; Region: Methyltransf_12; pfam08242
573825007820	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
573825007821	putative catalytic site [active]
573825007822	metal binding site A [ion binding]; metal-binding site
573825007823	phosphate binding site [ion binding]; other site
573825007824	metal binding site C [ion binding]; metal-binding site
573825007825	metal binding site B [ion binding]; metal-binding site
573825007826	DoxX-like family; Region: DoxX_2; pfam13564
573825007827	cyclase homology domain; Region: CHD; cd07302
573825007828	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825007829	nucleotidyl binding site; other site
573825007830	metal binding site [ion binding]; metal-binding site
573825007831	dimer interface [polypeptide binding]; other site
573825007832	cyclase homology domain; Region: CHD; cd07302
573825007833	dimer interface [polypeptide binding]; other site
573825007834	nucleotidyl binding site; other site
573825007835	metal binding site [ion binding]; metal-binding site
573825007836	AAA ATPase domain; Region: AAA_16; pfam13191
573825007837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825007838	binding surface
573825007839	TPR motif; other site
573825007840	Tetratricopeptide repeat; Region: TPR_12; pfam13424
573825007841	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
573825007842	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
573825007843	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
573825007844	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
573825007845	CoenzymeA binding site [chemical binding]; other site
573825007846	subunit interaction site [polypeptide binding]; other site
573825007847	PHB binding site; other site
573825007848	Transglycosylase; Region: Transgly; pfam00912
573825007849	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
573825007850	RibD C-terminal domain; Region: RibD_C; cl17279
573825007851	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
573825007852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825007853	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
573825007854	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
573825007855	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
573825007856	trimer interface [polypeptide binding]; other site
573825007857	putative metal binding site [ion binding]; other site
573825007858	phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472
573825007859	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
573825007860	putative tRNA-binding site [nucleotide binding]; other site
573825007861	B3/4 domain; Region: B3_4; pfam03483
573825007862	tRNA synthetase B5 domain; Region: B5; smart00874
573825007863	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
573825007864	dimer interface [polypeptide binding]; other site
573825007865	motif 1; other site
573825007866	motif 3; other site
573825007867	motif 2; other site
573825007868	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
573825007869	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
573825007870	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
573825007871	ATP binding site [chemical binding]; other site
573825007872	putative Mg++ binding site [ion binding]; other site
573825007873	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825007874	nucleotide binding region [chemical binding]; other site
573825007875	ATP-binding site [chemical binding]; other site
573825007876	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
573825007877	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
573825007878	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
573825007879	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
573825007880	putative acyl-acceptor binding pocket; other site
573825007881	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
573825007882	dimer interface [polypeptide binding]; other site
573825007883	substrate binding site [chemical binding]; other site
573825007884	metal binding sites [ion binding]; metal-binding site
573825007885	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
573825007886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825007887	putative substrate translocation pore; other site
573825007888	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
573825007889	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
573825007890	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
573825007891	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
573825007892	ATP binding site [chemical binding]; other site
573825007893	Mg++ binding site [ion binding]; other site
573825007894	motif III; other site
573825007895	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
573825007896	nucleotide binding region [chemical binding]; other site
573825007897	ATP-binding site [chemical binding]; other site
573825007898	Uncharacterized conserved protein [Function unknown]; Region: COG1262
573825007899	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
573825007900	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
573825007901	short chain dehydrogenase; Provisional; Region: PRK06181
573825007902	NADP binding site [chemical binding]; other site
573825007903	homodimer interface [polypeptide binding]; other site
573825007904	substrate binding site [chemical binding]; other site
573825007905	active site
573825007906	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
573825007907	Membrane transport protein; Region: Mem_trans; pfam03547
573825007908	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825007909	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825007910	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825007911	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825007912	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825007913	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825007914	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
573825007915	outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327
573825007916	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
573825007917	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
573825007918	homodimer interface [polypeptide binding]; other site
573825007919	metal binding site [ion binding]; metal-binding site
573825007920	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
573825007921	homodimer interface [polypeptide binding]; other site
573825007922	active site
573825007923	putative chemical substrate binding site [chemical binding]; other site
573825007924	metal binding site [ion binding]; metal-binding site
573825007925	Response regulator receiver domain; Region: Response_reg; pfam00072
573825007926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007927	active site
573825007928	phosphorylation site [posttranslational modification]
573825007929	intermolecular recognition site; other site
573825007930	dimerization interface [polypeptide binding]; other site
573825007931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
573825007932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007933	active site
573825007934	phosphorylation site [posttranslational modification]
573825007935	intermolecular recognition site; other site
573825007936	dimerization interface [polypeptide binding]; other site
573825007937	isocitrate dehydrogenase; Validated; Region: PRK08299
573825007938	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825007939	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825007940	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825007941	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825007942	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825007943	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
573825007944	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
573825007945	putative active site [active]
573825007946	catalytic triad [active]
573825007947	putative dimer interface [polypeptide binding]; other site
573825007948	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
573825007949	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
573825007950	hinge; other site
573825007951	active site
573825007952	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
573825007953	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
573825007954	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
573825007955	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
573825007956	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
573825007957	NADP binding site [chemical binding]; other site
573825007958	dimer interface [polypeptide binding]; other site
573825007959	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
573825007960	dimer interface [polypeptide binding]; other site
573825007961	[2Fe-2S] cluster binding site [ion binding]; other site
573825007962	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
573825007963	Vacuolar protein 14 C-terminal Fig4p binding; Region: Vac14_Fig4_bd; pfam11916
573825007964	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
573825007965	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
573825007966	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
573825007967	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
573825007968	active site
573825007969	tetramer interface [polypeptide binding]; other site
573825007970	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825007971	active site
573825007972	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
573825007973	catalytic site [active]
573825007974	putative active site [active]
573825007975	putative substrate binding site [chemical binding]; other site
573825007976	HRDC domain; Region: HRDC; pfam00570
573825007977	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
573825007978	putative active site [active]
573825007979	putative CoA binding site [chemical binding]; other site
573825007980	nudix motif; other site
573825007981	metal binding site [ion binding]; metal-binding site
573825007982	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
573825007983	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825007984	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825007985	DNA binding residues [nucleotide binding]
573825007986	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
573825007987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825007988	active site
573825007989	phosphorylation site [posttranslational modification]
573825007990	intermolecular recognition site; other site
573825007991	dimerization interface [polypeptide binding]; other site
573825007992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
573825007993	DNA binding site [nucleotide binding]
573825007994	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825007995	dimerization interface [polypeptide binding]; other site
573825007996	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
573825007997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825007998	dimer interface [polypeptide binding]; other site
573825007999	phosphorylation site [posttranslational modification]
573825008000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008001	ATP binding site [chemical binding]; other site
573825008002	Mg2+ binding site [ion binding]; other site
573825008003	G-X-G motif; other site
573825008004	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
573825008005	heterotetramer interface [polypeptide binding]; other site
573825008006	active site pocket [active]
573825008007	cleavage site
573825008008	Plasma-membrane choline transporter; Region: Choline_transpo; pfam04515
573825008009	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825008010	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825008011	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
573825008012	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
573825008013	active site
573825008014	DUF35 OB-fold domain; Region: DUF35; pfam01796
573825008015	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
573825008016	dimer interaction site [polypeptide binding]; other site
573825008017	substrate-binding tunnel; other site
573825008018	active site
573825008019	catalytic site [active]
573825008020	substrate binding site [chemical binding]; other site
573825008021	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
573825008022	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
573825008023	active site
573825008024	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
573825008025	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
573825008026	nucleotide binding pocket [chemical binding]; other site
573825008027	K-X-D-G motif; other site
573825008028	catalytic site [active]
573825008029	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
573825008030	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
573825008031	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
573825008032	Dimer interface [polypeptide binding]; other site
573825008033	BRCT sequence motif; other site
573825008034	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825008035	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825008036	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825008037	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825008038	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
573825008039	DNA binding residues [nucleotide binding]
573825008040	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
573825008041	dimer interface [polypeptide binding]; other site
573825008042	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
573825008043	putative active site [active]
573825008044	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
573825008045	Histidine kinase; Region: HisKA_2; pfam07568
573825008046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008047	Mg2+ binding site [ion binding]; other site
573825008048	G-X-G motif; other site
573825008049	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
573825008050	Histidine kinase; Region: HisKA_2; pfam07568
573825008051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008052	ATP binding site [chemical binding]; other site
573825008053	Mg2+ binding site [ion binding]; other site
573825008054	G-X-G motif; other site
573825008055	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
573825008056	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
573825008057	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
573825008058	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
573825008059	DNA binding residues [nucleotide binding]
573825008060	dimerization interface [polypeptide binding]; other site
573825008061	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
573825008062	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
573825008063	putative ADP-ribose binding site [chemical binding]; other site
573825008064	putative active site [active]
573825008065	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825008066	Predicted flavoprotein [General function prediction only]; Region: COG0431
573825008067	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
573825008068	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
573825008069	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
573825008070	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
573825008071	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
573825008072	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
573825008073	active site
573825008074	KWG Leptospira; Region: KWG; pfam07656
573825008075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
573825008076	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825008077	active site
573825008078	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
573825008079	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
573825008080	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
573825008081	dimer interface [polypeptide binding]; other site
573825008082	motif 1; other site
573825008083	active site
573825008084	motif 2; other site
573825008085	motif 3; other site
573825008086	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
573825008087	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
573825008088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
573825008089	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
573825008090	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
573825008091	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
573825008092	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
573825008093	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825008094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825008095	Walker A/P-loop; other site
573825008096	ATP binding site [chemical binding]; other site
573825008097	Q-loop/lid; other site
573825008098	ABC transporter signature motif; other site
573825008099	Walker B; other site
573825008100	D-loop; other site
573825008101	H-loop/switch region; other site
573825008102	DKNYY family; Region: DKNYY; pfam13644
573825008103	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
573825008104	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
573825008105	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
573825008106	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
573825008107	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
573825008108	active site
573825008109	Zn binding site [ion binding]; other site
573825008110	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
573825008111	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
573825008112	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
573825008113	active site
573825008114	Zn binding site [ion binding]; other site
573825008115	argininosuccinate synthase; Provisional; Region: PRK13820
573825008116	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
573825008117	ANP binding site [chemical binding]; other site
573825008118	Substrate Binding Site II [chemical binding]; other site
573825008119	Substrate Binding Site I [chemical binding]; other site
573825008120	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
573825008121	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
573825008122	active site
573825008123	(T/H)XGH motif; other site
573825008124	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
573825008125	active site
573825008126	multimer interface [polypeptide binding]; other site
573825008127	isocitrate dehydrogenase; Validated; Region: PRK09222
573825008128	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
573825008129	XAP5, circadian clock regulator; Region: XAP5; pfam04921
573825008130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825008131	Response regulator receiver domain; Region: Response_reg; pfam00072
573825008132	active site
573825008133	phosphorylation site [posttranslational modification]
573825008134	intermolecular recognition site; other site
573825008135	dimerization interface [polypeptide binding]; other site
573825008136	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825008137	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
573825008138	putative active site [active]
573825008139	heme pocket [chemical binding]; other site
573825008140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825008141	putative active site [active]
573825008142	heme pocket [chemical binding]; other site
573825008143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825008144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008145	ATP binding site [chemical binding]; other site
573825008146	Mg2+ binding site [ion binding]; other site
573825008147	G-X-G motif; other site
573825008148	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
573825008149	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
573825008150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825008151	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
573825008152	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
573825008153	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825008154	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
573825008155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825008156	homodimer interface [polypeptide binding]; other site
573825008157	catalytic residue [active]
573825008158	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
573825008159	active site
573825008160	Zn binding site [ion binding]; other site
573825008161	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
573825008162	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
573825008163	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
573825008164	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825008165	Protein of unknown function (DUF455); Region: DUF455; pfam04305
573825008166	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825008167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
573825008168	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
573825008169	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
573825008170	HIGH motif; other site
573825008171	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
573825008172	active site
573825008173	KMSKS motif; other site
573825008174	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
573825008175	CAP-like domain; other site
573825008176	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
573825008177	active site
573825008178	primary dimer interface [polypeptide binding]; other site
573825008179	TopoisomeraseII; Region: TOP2c; smart00433
573825008180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008181	ATP binding site [chemical binding]; other site
573825008182	Mg2+ binding site [ion binding]; other site
573825008183	G-X-G motif; other site
573825008184	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
573825008185	ATP binding site [chemical binding]; other site
573825008186	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
573825008187	active site
573825008188	putative metal-binding site [ion binding]; other site
573825008189	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817
573825008190	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
573825008191	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825008192	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
573825008193	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
573825008194	putative dimer interface [polypeptide binding]; other site
573825008195	active site pocket [active]
573825008196	putative cataytic base [active]
573825008197	cobalamin synthase; Reviewed; Region: cobS; PRK00235
573825008198	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
573825008199	catalytic core [active]
573825008200	von Willebrand factor type A domain; Region: VWA_2; pfam13519
573825008201	metal ion-dependent adhesion site (MIDAS); other site
573825008202	conserved hypothetical protein; Region: TIGR02231
573825008203	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
573825008204	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
573825008205	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
573825008206	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
573825008207	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
573825008208	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
573825008209	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
573825008210	Cl- selectivity filter; other site
573825008211	Cl- binding residues [ion binding]; other site
573825008212	pore gating glutamate residue; other site
573825008213	dimer interface [polypeptide binding]; other site
573825008214	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
573825008215	CAAX protease self-immunity; Region: Abi; pfam02517
573825008216	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825008217	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
573825008218	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825008219	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
573825008220	Strictosidine synthase; Region: Str_synth; pfam03088
573825008221	sulfite reductase subunit beta; Provisional; Region: PRK13504
573825008222	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
573825008223	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
573825008224	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
573825008225	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
573825008226	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
573825008227	active site
573825008228	SAM binding site [chemical binding]; other site
573825008229	homodimer interface [polypeptide binding]; other site
573825008230	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
573825008231	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
573825008232	CysD dimerization site [polypeptide binding]; other site
573825008233	G1 box; other site
573825008234	putative GEF interaction site [polypeptide binding]; other site
573825008235	GTP/Mg2+ binding site [chemical binding]; other site
573825008236	Switch I region; other site
573825008237	G2 box; other site
573825008238	G3 box; other site
573825008239	Switch II region; other site
573825008240	G4 box; other site
573825008241	G5 box; other site
573825008242	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
573825008243	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
573825008244	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
573825008245	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
573825008246	Active Sites [active]
573825008247	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
573825008248	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
573825008249	Active Sites [active]
573825008250	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
573825008251	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
573825008252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
573825008253	dimer interface [polypeptide binding]; other site
573825008254	conserved gate region; other site
573825008255	putative PBP binding loops; other site
573825008256	ABC-ATPase subunit interface; other site
573825008257	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
573825008258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
573825008259	dimer interface [polypeptide binding]; other site
573825008260	conserved gate region; other site
573825008261	putative PBP binding loops; other site
573825008262	ABC-ATPase subunit interface; other site
573825008263	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
573825008264	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
573825008265	Walker A/P-loop; other site
573825008266	ATP binding site [chemical binding]; other site
573825008267	Q-loop/lid; other site
573825008268	ABC transporter signature motif; other site
573825008269	Walker B; other site
573825008270	D-loop; other site
573825008271	H-loop/switch region; other site
573825008272	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
573825008273	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
573825008274	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
573825008275	Walker A/P-loop; other site
573825008276	ATP binding site [chemical binding]; other site
573825008277	Q-loop/lid; other site
573825008278	ABC transporter signature motif; other site
573825008279	Walker B; other site
573825008280	D-loop; other site
573825008281	H-loop/switch region; other site
573825008282	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
573825008283	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
573825008284	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
573825008285	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825008286	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
573825008287	Walker A/P-loop; other site
573825008288	ATP binding site [chemical binding]; other site
573825008289	Q-loop/lid; other site
573825008290	ABC transporter signature motif; other site
573825008291	Walker B; other site
573825008292	D-loop; other site
573825008293	H-loop/switch region; other site
573825008294	Caspase domain; Region: Peptidase_C14; pfam00656
573825008295	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
573825008296	ketol-acid reductoisomerase; Provisional; Region: PRK05479
573825008297	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
573825008298	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
573825008299	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
573825008300	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825008301	dimer interface [polypeptide binding]; other site
573825008302	putative CheW interface [polypeptide binding]; other site
573825008303	OsmC-like protein; Region: OsmC; cl00767
573825008304	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
573825008305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
573825008306	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
573825008307	putative active site [active]
573825008308	putative metal binding site [ion binding]; other site
573825008309	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
573825008310	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
573825008311	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
573825008312	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
573825008313	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
573825008314	dimer interface [polypeptide binding]; other site
573825008315	putative CheW interface [polypeptide binding]; other site
573825008316	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825008317	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825008318	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
573825008319	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
573825008320	DNA binding site [nucleotide binding]
573825008321	active site
573825008322	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
573825008323	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
573825008324	cobalamin binding residues [chemical binding]; other site
573825008325	putative BtuC binding residues; other site
573825008326	dimer interface [polypeptide binding]; other site
573825008327	acetyl-CoA synthetase; Provisional; Region: PRK00174
573825008328	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
573825008329	active site
573825008330	CoA binding site [chemical binding]; other site
573825008331	acyl-activating enzyme (AAE) consensus motif; other site
573825008332	AMP binding site [chemical binding]; other site
573825008333	acetate binding site [chemical binding]; other site
573825008334	GTP cyclohydrolase I; Provisional; Region: PLN03044
573825008335	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
573825008336	homodecamer interface [polypeptide binding]; other site
573825008337	active site
573825008338	putative catalytic site residues [active]
573825008339	zinc binding site [ion binding]; other site
573825008340	GTP-CH-I/GFRP interaction surface; other site
573825008341	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825008342	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
573825008343	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
573825008344	putative hydrophobic ligand binding site [chemical binding]; other site
573825008345	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
573825008346	extended (e) SDRs; Region: SDR_e; cd08946
573825008347	NAD(P) binding site [chemical binding]; other site
573825008348	active site
573825008349	substrate binding site [chemical binding]; other site
573825008350	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
573825008351	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
573825008352	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
573825008353	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
573825008354	putative acyl-acceptor binding pocket; other site
573825008355	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
573825008356	ATP-grasp domain; Region: ATP-grasp; pfam02222
573825008357	FecR protein; Region: FecR; pfam04773
573825008358	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
573825008359	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825008360	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825008361	Domain of unknown function (DUF897); Region: DUF897; pfam05982
573825008362	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
573825008363	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
573825008364	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
573825008365	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
573825008366	hydrogenase 4 subunit F; Validated; Region: PRK06458
573825008367	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
573825008368	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
573825008369	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
573825008370	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
573825008371	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
573825008372	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
573825008373	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
573825008374	active site
573825008375	Fructosamine kinase; Region: Fructosamin_kin; cl17579
573825008376	Phosphotransferase enzyme family; Region: APH; pfam01636
573825008377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825008378	Walker A/P-loop; other site
573825008379	ATP binding site [chemical binding]; other site
573825008380	Q-loop/lid; other site
573825008381	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
573825008382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
573825008383	ABC transporter signature motif; other site
573825008384	Walker B; other site
573825008385	D-loop; other site
573825008386	H-loop/switch region; other site
573825008387	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
573825008388	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
573825008389	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
573825008390	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
573825008391	quinone interaction residues [chemical binding]; other site
573825008392	active site
573825008393	catalytic residues [active]
573825008394	FMN binding site [chemical binding]; other site
573825008395	substrate binding site [chemical binding]; other site
573825008396	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
573825008397	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
573825008398	catalytic core [active]
573825008399	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825008400	active site
573825008401	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
573825008402	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
573825008403	TrkA-N domain; Region: TrkA_N; pfam02254
573825008404	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
573825008405	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
573825008406	MarR family; Region: MarR; pfam01047
573825008407	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
573825008408	catalytic residues [active]
573825008409	dimer interface [polypeptide binding]; other site
573825008410	intracellular protease, PfpI family; Region: PfpI; TIGR01382
573825008411	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
573825008412	conserved cys residue [active]
573825008413	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
573825008414	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
573825008415	TrkA-N domain; Region: TrkA_N; pfam02254
573825008416	Short C-terminal domain; Region: SHOCT; pfam09851
573825008417	carbon storage regulator; Provisional; Region: PRK01712
573825008418	flagellar assembly protein FliW; Provisional; Region: PRK13285
573825008419	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
573825008420	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
573825008421	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
573825008422	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
573825008423	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
573825008424	FlgN protein; Region: FlgN; pfam05130
573825008425	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825008426	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825008427	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
573825008428	Intermediate filament protein; Region: Filament; pfam00038
573825008429	TRL-like protein family; Region: TRL; pfam13146
573825008430	Protein of unknown function (DUF423); Region: DUF423; pfam04241
573825008431	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
573825008432	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
573825008433	active site
573825008434	Zn binding site [ion binding]; other site
573825008435	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825008436	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
573825008437	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
573825008438	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
573825008439	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
573825008440	trimer interface [polypeptide binding]; other site
573825008441	active site
573825008442	UDP-GlcNAc binding site [chemical binding]; other site
573825008443	lipid binding site [chemical binding]; lipid-binding site
573825008444	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
573825008445	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
573825008446	FAD binding pocket [chemical binding]; other site
573825008447	conserved FAD binding motif [chemical binding]; other site
573825008448	phosphate binding motif [ion binding]; other site
573825008449	beta-alpha-beta structure motif; other site
573825008450	NAD binding pocket [chemical binding]; other site
573825008451	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
573825008452	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
573825008453	nucleoside/Zn binding site; other site
573825008454	dimer interface [polypeptide binding]; other site
573825008455	catalytic motif [active]
573825008456	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14956
573825008457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
573825008458	Walker A motif; other site
573825008459	ATP binding site [chemical binding]; other site
573825008460	Walker B motif; other site
573825008461	arginine finger; other site
573825008462	hypothetical protein; Provisional; Region: PRK14624
573825008463	recombination protein RecR; Reviewed; Region: recR; PRK00076
573825008464	RecR protein; Region: RecR; pfam02132
573825008465	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
573825008466	putative active site [active]
573825008467	putative metal-binding site [ion binding]; other site
573825008468	tetramer interface [polypeptide binding]; other site
573825008469	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
573825008470	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
573825008471	substrate binding pocket [chemical binding]; other site
573825008472	membrane-bound complex binding site; other site
573825008473	hinge residues; other site
573825008474	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
573825008475	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825008476	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825008477	ligand binding site [chemical binding]; other site
573825008478	seryl-tRNA synthetase; Provisional; Region: PRK05431
573825008479	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
573825008480	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
573825008481	dimer interface [polypeptide binding]; other site
573825008482	active site
573825008483	motif 1; other site
573825008484	motif 2; other site
573825008485	motif 3; other site
573825008486	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
573825008487	active site
573825008488	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
573825008489	Peptidase family M23; Region: Peptidase_M23; pfam01551
573825008490	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
573825008491	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
573825008492	Protein of unknown function (DUF327); Region: DUF327; pfam03885
573825008493	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
573825008494	ParB-like nuclease domain; Region: ParB; smart00470
573825008495	KorB domain; Region: KorB; pfam08535
573825008496	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
573825008497	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825008498	P-loop; other site
573825008499	Magnesium ion binding site [ion binding]; other site
573825008500	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825008501	Magnesium ion binding site [ion binding]; other site
573825008502	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
573825008503	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
573825008504	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
573825008505	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
573825008506	putative metal binding site [ion binding]; other site
573825008507	pyruvate dehydrogenase E1 component, homodimeric type; Region: aceE; TIGR00759
573825008508	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
573825008509	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
573825008510	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
573825008511	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
573825008512	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
573825008513	homodimer interface [polypeptide binding]; other site
573825008514	substrate-cofactor binding pocket; other site
573825008515	catalytic residue [active]
573825008516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
573825008517	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
573825008518	DNA polymerase III subunit delta'; Validated; Region: PRK08485
573825008519	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
573825008520	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
573825008521	FAD binding site [chemical binding]; other site
573825008522	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
573825008523	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
573825008524	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
573825008525	active site
573825008526	motif I; other site
573825008527	motif II; other site
573825008528	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
573825008529	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
573825008530	NAD(P) binding pocket [chemical binding]; other site
573825008531	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
573825008532	porphobilinogen deaminase; Region: hemC; TIGR00212
573825008533	domain interfaces; other site
573825008534	active site
573825008535	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
573825008536	dimer interface [polypeptide binding]; other site
573825008537	active site
573825008538	Schiff base residues; other site
573825008539	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
573825008540	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
573825008541	inhibitor-cofactor binding pocket; inhibition site
573825008542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825008543	catalytic residue [active]
573825008544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825008545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825008546	dimer interface [polypeptide binding]; other site
573825008547	phosphorylation site [posttranslational modification]
573825008548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008549	ATP binding site [chemical binding]; other site
573825008550	Mg2+ binding site [ion binding]; other site
573825008551	G-X-G motif; other site
573825008552	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
573825008553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825008554	active site
573825008555	phosphorylation site [posttranslational modification]
573825008556	intermolecular recognition site; other site
573825008557	dimerization interface [polypeptide binding]; other site
573825008558	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
573825008559	DNA binding site [nucleotide binding]
573825008560	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
573825008561	substrate binding site [chemical binding]; other site
573825008562	active site
573825008563	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
573825008564	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
573825008565	FeS/SAM binding site; other site
573825008566	HemN C-terminal domain; Region: HemN_C; pfam06969
573825008567	protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562
573825008568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
573825008569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825008570	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825008571	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825008572	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
573825008573	active site
573825008574	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
573825008575	active site
573825008576	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
573825008577	active site
573825008578	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
573825008579	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825008580	P-loop; other site
573825008581	Magnesium ion binding site [ion binding]; other site
573825008582	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825008583	Magnesium ion binding site [ion binding]; other site
573825008584	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
573825008585	ParB-like nuclease domain; Region: ParB; smart00470
573825008586	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
573825008587	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
573825008588	Acyltransferase family; Region: Acyl_transf_3; pfam01757
573825008589	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
573825008590	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
573825008591	ligand binding site [chemical binding]; other site
573825008592	flexible hinge region; other site
573825008593	short chain dehydrogenase; Provisional; Region: PRK08251
573825008594	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
573825008595	putative NAD(P) binding site [chemical binding]; other site
573825008596	active site
573825008597	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
573825008598	Low molecular weight phosphatase family; Region: LMWPc; cd00115
573825008599	active site
573825008600	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
573825008601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
573825008602	short chain dehydrogenase; Provisional; Region: PRK06181
573825008603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
573825008604	NAD(P) binding site [chemical binding]; other site
573825008605	active site
573825008606	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
573825008607	putative hydrophobic ligand binding site [chemical binding]; other site
573825008608	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
573825008609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
573825008610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
573825008611	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825008612	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825008613	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825008614	MoxR-like ATPases [General function prediction only]; Region: COG0714
573825008615	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
573825008616	Walker A motif; other site
573825008617	ATP binding site [chemical binding]; other site
573825008618	Walker B motif; other site
573825008619	arginine finger; other site
573825008620	Protein of unknown function DUF58; Region: DUF58; pfam01882
573825008621	von Willebrand factor type A domain; Region: VWA_2; pfam13519
573825008622	Aerotolerance regulator N-terminal; Region: BatA; cl06567
573825008623	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
573825008624	metal ion-dependent adhesion site (MIDAS); other site
573825008625	von Willebrand factor type A domain; Region: VWA_2; pfam13519
573825008626	metal ion-dependent adhesion site (MIDAS); other site
573825008627	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825008628	binding surface
573825008629	TPR motif; other site
573825008630	TPR repeat; Region: TPR_11; pfam13414
573825008631	Oxygen tolerance; Region: BatD; pfam13584
573825008632	RecX family; Region: RecX; cl00936
573825008633	heat shock protein 90; Provisional; Region: PRK05218
573825008634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008635	ATP binding site [chemical binding]; other site
573825008636	Mg2+ binding site [ion binding]; other site
573825008637	G-X-G motif; other site
573825008638	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
573825008639	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825008640	anti sigma factor interaction site; other site
573825008641	regulatory phosphorylation site [posttranslational modification]; other site
573825008642	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
573825008643	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
573825008644	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
573825008645	Fatty acid desaturase; Region: FA_desaturase; pfam00487
573825008646	Di-iron ligands [ion binding]; other site
573825008647	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
573825008648	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
573825008649	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
573825008650	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825008651	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
573825008652	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681
573825008653	putative active site [active]
573825008654	putative substrate binding site [chemical binding]; other site
573825008655	putative coenzyme B12 binding site [chemical binding]; other site
573825008656	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
573825008657	B12 binding site [chemical binding]; other site
573825008658	cobalt ligand [ion binding]; other site
573825008659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825008660	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825008661	S-adenosylmethionine binding site [chemical binding]; other site
573825008662	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
573825008663	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
573825008664	catalytic residues [active]
573825008665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
573825008666	binding surface
573825008667	Tetratricopeptide repeat; Region: TPR_16; pfam13432
573825008668	TPR motif; other site
573825008669	TPR repeat; Region: TPR_11; pfam13414
573825008670	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
573825008671	metal binding site [ion binding]; metal-binding site
573825008672	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
573825008673	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
573825008674	NAD(P) binding site [chemical binding]; other site
573825008675	homotetramer interface [polypeptide binding]; other site
573825008676	homodimer interface [polypeptide binding]; other site
573825008677	active site
573825008678	acyl carrier protein; Provisional; Region: acpP; PRK00982
573825008679	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
573825008680	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
573825008681	dimerization interface [polypeptide binding]; other site
573825008682	active site
573825008683	metal binding site [ion binding]; metal-binding site
573825008684	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
573825008685	dsRNA binding site [nucleotide binding]; other site
573825008686	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
573825008687	nudix motif; other site
573825008688	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
573825008689	active site
573825008690	dimer interface [polypeptide binding]; other site
573825008691	metal binding site [ion binding]; metal-binding site
573825008692	Mechanosensitive ion channel; Region: MS_channel; pfam00924
573825008693	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
573825008694	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
573825008695	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
573825008696	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
573825008697	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
573825008698	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
573825008699	acyl-activating enzyme (AAE) consensus motif; other site
573825008700	putative AMP binding site [chemical binding]; other site
573825008701	putative active site [active]
573825008702	putative CoA binding site [chemical binding]; other site
573825008703	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
573825008704	dimerization interface [polypeptide binding]; other site
573825008705	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825008706	cyclase homology domain; Region: CHD; cd07302
573825008707	nucleotidyl binding site; other site
573825008708	metal binding site [ion binding]; metal-binding site
573825008709	dimer interface [polypeptide binding]; other site
573825008710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825008711	S-adenosylmethionine binding site [chemical binding]; other site
573825008712	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
573825008713	putative active site [active]
573825008714	putative metal binding site [ion binding]; other site
573825008715	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
573825008716	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
573825008717	active site
573825008718	motif I; other site
573825008719	motif II; other site
573825008720	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
573825008721	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825008722	active site
573825008723	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825008724	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825008725	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
573825008726	dimerization interface [polypeptide binding]; other site
573825008727	putative DNA binding site [nucleotide binding]; other site
573825008728	putative Zn2+ binding site [ion binding]; other site
573825008729	Methyltransferase domain; Region: Methyltransf_23; pfam13489
573825008730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825008731	S-adenosylmethionine binding site [chemical binding]; other site
573825008732	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
573825008733	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
573825008734	homotetramer interface [polypeptide binding]; other site
573825008735	ligand binding site [chemical binding]; other site
573825008736	catalytic site [active]
573825008737	NAD binding site [chemical binding]; other site
573825008738	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
573825008739	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
573825008740	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
573825008741	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
573825008742	substrate binding pocket [chemical binding]; other site
573825008743	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
573825008744	B12 binding site [chemical binding]; other site
573825008745	cobalt ligand [ion binding]; other site
573825008746	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
573825008747	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
573825008748	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
573825008749	active site
573825008750	ADP/pyrophosphate binding site [chemical binding]; other site
573825008751	dimerization interface [polypeptide binding]; other site
573825008752	allosteric effector site; other site
573825008753	fructose-1,6-bisphosphate binding site; other site
573825008754	GAF domain; Region: GAF_2; pfam13185
573825008755	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825008756	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
573825008757	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
573825008758	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825008759	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825008760	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
573825008761	homohexameric interface [polypeptide binding]; other site
573825008762	feedback inhibition sensing region; other site
573825008763	nucleotide binding site [chemical binding]; other site
573825008764	N-acetyl-L-glutamate binding site [chemical binding]; other site
573825008765	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
573825008766	classical (c) SDRs; Region: SDR_c; cd05233
573825008767	NAD(P) binding site [chemical binding]; other site
573825008768	active site
573825008769	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
573825008770	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
573825008771	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
573825008772	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
573825008773	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
573825008774	catalytic triad [active]
573825008775	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825008776	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
573825008777	cyclase homology domain; Region: CHD; cd07302
573825008778	nucleotidyl binding site; other site
573825008779	metal binding site [ion binding]; metal-binding site
573825008780	dimer interface [polypeptide binding]; other site
573825008781	Tetratricopeptide repeat; Region: TPR_2; pfam07719
573825008782	classical (c) SDRs; Region: SDR_c; cd05233
573825008783	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
573825008784	NAD(P) binding site [chemical binding]; other site
573825008785	active site
573825008786	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
573825008787	active site
573825008788	DNA binding site [nucleotide binding]
573825008789	Int/Topo IB signature motif; other site
573825008790	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
573825008791	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
573825008792	ADP binding site [chemical binding]; other site
573825008793	magnesium binding site [ion binding]; other site
573825008794	putative shikimate binding site; other site
573825008795	HDOD domain; Region: HDOD; pfam08668
573825008796	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
573825008797	Zn2+ binding site [ion binding]; other site
573825008798	Mg2+ binding site [ion binding]; other site
573825008799	CheD chemotactic sensory transduction; Region: CheD; cl00810
573825008800	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
573825008801	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
573825008802	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825008803	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825008804	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825008805	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825008806	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825008807	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
573825008808	anti sigma factor interaction site; other site
573825008809	regulatory phosphorylation site [posttranslational modification]; other site
573825008810	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615
573825008811	HAMP domain; Region: HAMP; pfam00672
573825008812	dimerization interface [polypeptide binding]; other site
573825008813	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
573825008814	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
573825008815	FecR protein; Region: FecR; pfam04773
573825008816	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
573825008817	FecR protein; Region: FecR; pfam04773
573825008818	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
573825008819	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
573825008820	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
573825008821	DNA binding residues [nucleotide binding]
573825008822	hypothetical protein; Provisional; Region: PRK10030
573825008823	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825008824	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
573825008825	catalytic core [active]
573825008826	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
573825008827	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
573825008828	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
573825008829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
573825008830	homodimer interface [polypeptide binding]; other site
573825008831	catalytic residue [active]
573825008832	cobyric acid synthase; Provisional; Region: PRK00784
573825008833	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
573825008834	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
573825008835	catalytic triad [active]
573825008836	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
573825008837	homotrimer interface [polypeptide binding]; other site
573825008838	Walker A motif; other site
573825008839	GTP binding site [chemical binding]; other site
573825008840	Walker B motif; other site
573825008841	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
573825008842	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
573825008843	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
573825008844	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
573825008845	catalytic triad [active]
573825008846	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
573825008847	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
573825008848	homodimer interface [polypeptide binding]; other site
573825008849	Walker A motif; other site
573825008850	ATP binding site [chemical binding]; other site
573825008851	hydroxycobalamin binding site [chemical binding]; other site
573825008852	Walker B motif; other site
573825008853	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
573825008854	active site
573825008855	SAM binding site [chemical binding]; other site
573825008856	homodimer interface [polypeptide binding]; other site
573825008857	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
573825008858	active site
573825008859	SAM binding site [chemical binding]; other site
573825008860	homodimer interface [polypeptide binding]; other site
573825008861	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
573825008862	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
573825008863	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
573825008864	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
573825008865	active site
573825008866	SAM binding site [chemical binding]; other site
573825008867	homodimer interface [polypeptide binding]; other site
573825008868	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
573825008869	active site
573825008870	putative homodimer interface [polypeptide binding]; other site
573825008871	SAM binding site [chemical binding]; other site
573825008872	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
573825008873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825008874	Precorrin-8X methylmutase; Region: CbiC; pfam02570
573825008875	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
573825008876	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
573825008877	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
573825008878	FAD binding pocket [chemical binding]; other site
573825008879	conserved FAD binding motif [chemical binding]; other site
573825008880	phosphate binding motif [ion binding]; other site
573825008881	beta-alpha-beta structure motif; other site
573825008882	NAD binding pocket [chemical binding]; other site
573825008883	Protein of unknown function (DUF3209); Region: DUF3209; pfam11483
573825008884	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
573825008885	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
573825008886	putative active site [active]
573825008887	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
573825008888	putative active site [active]
573825008889	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
573825008890	dimer interface [polypeptide binding]; other site
573825008891	[2Fe-2S] cluster binding site [ion binding]; other site
573825008892	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
573825008893	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
573825008894	NAD(P) binding site [chemical binding]; other site
573825008895	homodimer interface [polypeptide binding]; other site
573825008896	substrate binding site [chemical binding]; other site
573825008897	active site
573825008898	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
573825008899	heat shock protein HtpX; Provisional; Region: PRK05457
573825008900	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
573825008901	active site
573825008902	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
573825008903	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
573825008904	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825008905	protein binding site [polypeptide binding]; other site
573825008906	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
573825008907	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
573825008908	protein binding site [polypeptide binding]; other site
573825008909	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
573825008910	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
573825008911	metal binding site 2 [ion binding]; metal-binding site
573825008912	putative DNA binding helix; other site
573825008913	metal binding site 1 [ion binding]; metal-binding site
573825008914	dimer interface [polypeptide binding]; other site
573825008915	structural Zn2+ binding site [ion binding]; other site
573825008916	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
573825008917	heme binding pocket [chemical binding]; other site
573825008918	heme ligand [chemical binding]; other site
573825008919	Major Facilitator Superfamily; Region: MFS_1; pfam07690
573825008920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825008921	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
573825008922	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
573825008923	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
573825008924	N-terminal plug; other site
573825008925	ligand-binding site [chemical binding]; other site
573825008926	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
573825008927	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
573825008928	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
573825008929	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
573825008930	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
573825008931	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
573825008932	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
573825008933	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
573825008934	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
573825008935	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
573825008936	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825008937	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
573825008938	catalytic triad [active]
573825008939	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825008940	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
573825008941	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
573825008942	homodimer interface [polypeptide binding]; other site
573825008943	metal binding site [ion binding]; metal-binding site
573825008944	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
573825008945	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
573825008946	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
573825008947	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
573825008948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825008949	S-adenosylmethionine binding site [chemical binding]; other site
573825008950	Protease prsW family; Region: PrsW-protease; pfam13367
573825008951	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
573825008952	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
573825008953	putative transposase OrfB; Reviewed; Region: PHA02517
573825008954	Integrase core domain; Region: rve; pfam00665
573825008955	Integrase core domain; Region: rve_3; pfam13683
573825008956	Transposase; Region: HTH_Tnp_1; pfam01527
573825008957	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825008958	Putative Ig domain; Region: He_PIG; pfam05345
573825008959	Putative Ig domain; Region: He_PIG; pfam05345
573825008960	Putative Ig domain; Region: He_PIG; pfam05345
573825008961	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825008962	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825008963	Helix-turn-helix domain; Region: HTH_18; pfam12833
573825008964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
573825008965	Transposase; Region: HTH_Tnp_1; pfam01527
573825008966	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825008967	putative transposase OrfB; Reviewed; Region: PHA02517
573825008968	Integrase core domain; Region: rve; pfam00665
573825008969	Integrase core domain; Region: rve_3; pfam13683
573825008970	Response regulator receiver domain; Region: Response_reg; pfam00072
573825008971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825008972	active site
573825008973	phosphorylation site [posttranslational modification]
573825008974	intermolecular recognition site; other site
573825008975	dimerization interface [polypeptide binding]; other site
573825008976	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
573825008977	nucleotidyl binding site; other site
573825008978	metal binding site [ion binding]; metal-binding site
573825008979	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
573825008980	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825008981	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825008982	metal binding site [ion binding]; metal-binding site
573825008983	active site
573825008984	I-site; other site
573825008985	Cache domain; Region: Cache_1; pfam02743
573825008986	Cache domain; Region: Cache_1; pfam02743
573825008987	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
573825008988	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
573825008989	metal binding site [ion binding]; metal-binding site
573825008990	active site
573825008991	I-site; other site
573825008992	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
573825008993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825008994	dimer interface [polypeptide binding]; other site
573825008995	phosphorylation site [posttranslational modification]
573825008996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825008997	ATP binding site [chemical binding]; other site
573825008998	Mg2+ binding site [ion binding]; other site
573825008999	G-X-G motif; other site
573825009000	Response regulator receiver domain; Region: Response_reg; pfam00072
573825009001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825009002	active site
573825009003	phosphorylation site [posttranslational modification]
573825009004	intermolecular recognition site; other site
573825009005	dimerization interface [polypeptide binding]; other site
573825009006	FecR protein; Region: FecR; pfam04773
573825009007	Patatin-like phospholipase; Region: Patatin; pfam01734
573825009008	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
573825009009	Na binding site [ion binding]; other site
573825009010	putative glycosylation site [posttranslational modification]; other site
573825009011	putative glycosylation site [posttranslational modification]; other site
573825009012	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
573825009013	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
573825009014	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
573825009015	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
573825009016	active site
573825009017	nucleophile elbow; other site
573825009018	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
573825009019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
573825009020	putative substrate translocation pore; other site
573825009021	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
573825009022	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
573825009023	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
573825009024	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
573825009025	active site
573825009026	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
573825009027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
573825009028	active site
573825009029	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
573825009030	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
573825009031	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
573825009032	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
573825009033	Sodium Bile acid symporter family; Region: SBF; pfam01758
573825009034	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
573825009035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
573825009036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
573825009037	catalytic residue [active]
573825009038	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
573825009039	diiron binding motif [ion binding]; other site
573825009040	YhhN-like protein; Region: YhhN; pfam07947
573825009041	Integral membrane protein TerC family; Region: TerC; cl10468
573825009042	Integral membrane protein TerC family; Region: TerC; cl10468
573825009043	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
573825009044	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
573825009045	heterodimer interface [polypeptide binding]; other site
573825009046	substrate interaction site [chemical binding]; other site
573825009047	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
573825009048	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
573825009049	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
573825009050	active site
573825009051	substrate binding site [chemical binding]; other site
573825009052	coenzyme B12 binding site [chemical binding]; other site
573825009053	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
573825009054	B12 binding site [chemical binding]; other site
573825009055	cobalt ligand [ion binding]; other site
573825009056	membrane ATPase/protein kinase; Provisional; Region: PRK09435
573825009057	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
573825009058	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
573825009059	Walker A; other site
573825009060	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
573825009061	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
573825009062	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
573825009063	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
573825009064	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
573825009065	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
573825009066	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
573825009067	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
573825009068	putative active site [active]
573825009069	putative metal binding site [ion binding]; other site
573825009070	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
573825009071	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
573825009072	active site
573825009073	FMN binding site [chemical binding]; other site
573825009074	substrate binding site [chemical binding]; other site
573825009075	3Fe-4S cluster binding site [ion binding]; other site
573825009076	Yip1 domain; Region: Yip1; pfam04893
573825009077	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
573825009078	active site
573825009079	PAS domain S-box; Region: sensory_box; TIGR00229
573825009080	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
573825009081	putative active site [active]
573825009082	heme pocket [chemical binding]; other site
573825009083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825009084	dimer interface [polypeptide binding]; other site
573825009085	phosphorylation site [posttranslational modification]
573825009086	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
573825009087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825009088	ATP binding site [chemical binding]; other site
573825009089	Mg2+ binding site [ion binding]; other site
573825009090	G-X-G motif; other site
573825009091	short chain dehydrogenase; Provisional; Region: PRK07454
573825009092	classical (c) SDRs; Region: SDR_c; cd05233
573825009093	NAD(P) binding site [chemical binding]; other site
573825009094	active site
573825009095	methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328
573825009096	intersubunit interface [polypeptide binding]; other site
573825009097	active site
573825009098	Zn2+ binding site [ion binding]; other site
573825009099	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
573825009100	Cupin domain; Region: Cupin_2; pfam07883
573825009101	elongation factor P; Validated; Region: PRK00529
573825009102	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
573825009103	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
573825009104	RNA binding site [nucleotide binding]; other site
573825009105	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
573825009106	RNA binding site [nucleotide binding]; other site
573825009107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825009108	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825009109	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825009110	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
573825009111	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
573825009112	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
573825009113	putative transposase OrfB; Reviewed; Region: PHA02517
573825009114	Integrase core domain; Region: rve; pfam00665
573825009115	Integrase core domain; Region: rve_3; pfam13683
573825009116	Transposase; Region: HTH_Tnp_1; pfam01527
573825009117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825009118	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
573825009119	Predicted membrane protein [Function unknown]; Region: COG1238
573825009120	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825009121	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
573825009122	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
573825009123	active site
573825009124	dimer interface [polypeptide binding]; other site
573825009125	spermidine synthase; Provisional; Region: PRK00811
573825009126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
573825009127	S-adenosylmethionine binding site [chemical binding]; other site
573825009128	SET domain; Region: SET; cl02566
573825009129	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
573825009130	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
573825009131	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
573825009132	alanine racemase; Reviewed; Region: alr; PRK00053
573825009133	active site
573825009134	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
573825009135	dimer interface [polypeptide binding]; other site
573825009136	substrate binding site [chemical binding]; other site
573825009137	catalytic residues [active]
573825009138	Phosphate acyltransferases; Region: PlsC; smart00563
573825009139	putative acyl-acceptor binding pocket; other site
573825009140	Sec24-related protein; Provisional; Region: PTZ00395
573825009141	NMT1/THI5 like; Region: NMT1; pfam09084
573825009142	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
573825009143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
573825009144	dimer interface [polypeptide binding]; other site
573825009145	phosphorylation site [posttranslational modification]
573825009146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
573825009147	ATP binding site [chemical binding]; other site
573825009148	Mg2+ binding site [ion binding]; other site
573825009149	G-X-G motif; other site
573825009150	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
573825009151	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
573825009152	N-acetyl-D-glucosamine binding site [chemical binding]; other site
573825009153	catalytic residue [active]
573825009154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
573825009155	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
573825009156	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
573825009157	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
573825009158	substrate binding site [chemical binding]; other site
573825009159	ligand binding site [chemical binding]; other site
573825009160	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
573825009161	substrate binding site [chemical binding]; other site
573825009162	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
573825009163	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
573825009164	ligand binding site [chemical binding]; other site
573825009165	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
573825009166	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
573825009167	motif 1; other site
573825009168	dimer interface [polypeptide binding]; other site
573825009169	active site
573825009170	motif 2; other site
573825009171	motif 3; other site
573825009172	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
573825009173	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
573825009174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
573825009175	active site
573825009176	phosphorylation site [posttranslational modification]
573825009177	intermolecular recognition site; other site
573825009178	dimerization interface [polypeptide binding]; other site
573825009179	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
573825009180	DNA binding site [nucleotide binding]
573825009181	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
573825009182	aromatic arch; other site
573825009183	DCoH dimer interaction site [polypeptide binding]; other site
573825009184	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
573825009185	DCoH tetramer interaction site [polypeptide binding]; other site
573825009186	substrate binding site [chemical binding]; other site
573825009187	phosphodiesterase; Provisional; Region: PRK12704
573825009188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
573825009189	Transposase; Region: DEDD_Tnp_IS110; pfam01548
573825009190	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
573825009191	Transposase; Region: HTH_Tnp_1; pfam01527
573825009192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
573825009193	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
573825009194	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
573825009195	pyruvate kinase; Provisional; Region: PRK05826
573825009196	domain interfaces; other site
573825009197	active site
573825009198	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
573825009199	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
573825009200	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
573825009201	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
573825009202	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
573825009203	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825009204	P-loop; other site
573825009205	Magnesium ion binding site [ion binding]; other site
573825009206	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
573825009207	Magnesium ion binding site [ion binding]; other site
573825009208	ParB-like nuclease domain; Region: ParB; smart00470
573825009209	Helix-turn-helix domain; Region: HTH_36; pfam13730