-- dump date 20140619_131523 -- class Genbank::misc_feature -- table misc_feature_note -- id note 395495000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 395495000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495000004 Walker A motif; other site 395495000005 ATP binding site [chemical binding]; other site 395495000006 Walker B motif; other site 395495000007 arginine finger; other site 395495000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 395495000009 DnaA box-binding interface [nucleotide binding]; other site 395495000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 395495000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 395495000012 putative DNA binding surface [nucleotide binding]; other site 395495000013 dimer interface [polypeptide binding]; other site 395495000014 beta-clamp/clamp loader binding surface; other site 395495000015 beta-clamp/translesion DNA polymerase binding surface; other site 395495000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 395495000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000018 ATP binding site [chemical binding]; other site 395495000019 Mg2+ binding site [ion binding]; other site 395495000020 G-X-G motif; other site 395495000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 395495000022 anchoring element; other site 395495000023 dimer interface [polypeptide binding]; other site 395495000024 ATP binding site [chemical binding]; other site 395495000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 395495000026 active site 395495000027 putative metal-binding site [ion binding]; other site 395495000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 395495000029 tellurium resistance terB-like protein; Region: terB_like; cd07177 395495000030 metal binding site [ion binding]; metal-binding site 395495000031 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 395495000032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495000033 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 395495000034 putative dimerization interface [polypeptide binding]; other site 395495000035 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 395495000036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495000037 PAS domain; Region: PAS_9; pfam13426 395495000038 putative active site [active] 395495000039 heme pocket [chemical binding]; other site 395495000040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495000041 PAS fold; Region: PAS_3; pfam08447 395495000042 putative active site [active] 395495000043 heme pocket [chemical binding]; other site 395495000044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 395495000045 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395495000046 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395495000047 Peptidase M15; Region: Peptidase_M15_3; cl01194 395495000048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 395495000049 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 395495000050 mce related protein; Region: MCE; pfam02470 395495000051 Permease; Region: Permease; cl00510 395495000052 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 395495000053 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 395495000054 homodimer interface [polypeptide binding]; other site 395495000055 chemical substrate binding site [chemical binding]; other site 395495000056 oligomer interface [polypeptide binding]; other site 395495000057 metal binding site [ion binding]; metal-binding site 395495000058 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 395495000059 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 395495000060 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 395495000061 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 395495000062 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 395495000063 putative active site [active] 395495000064 Tetratricopeptide repeat; Region: TPR_15; pfam13429 395495000065 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 395495000066 GAF domain; Region: GAF_3; pfam13492 395495000067 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 395495000068 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495000069 Predicted membrane protein [Function unknown]; Region: COG4267 395495000070 Rossmann-like domain; Region: Rossmann-like; pfam10727 395495000071 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 395495000072 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 395495000073 active site 395495000074 catalytic site [active] 395495000075 substrate binding site [chemical binding]; other site 395495000076 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 395495000077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495000078 DNA-binding site [nucleotide binding]; DNA binding site 395495000079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495000080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495000081 homodimer interface [polypeptide binding]; other site 395495000082 catalytic residue [active] 395495000083 OsmC-like protein; Region: OsmC; cl00767 395495000084 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 395495000085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495000086 Coenzyme A binding pocket [chemical binding]; other site 395495000087 Domain of unknown function (DUF427); Region: DUF427; pfam04248 395495000088 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 395495000089 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 395495000090 Cytochrome c; Region: Cytochrom_C; cl11414 395495000091 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 395495000092 septum formation inhibitor; Reviewed; Region: PRK01973 395495000093 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 395495000094 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 395495000095 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 395495000096 Switch I; other site 395495000097 Switch II; other site 395495000098 cell division topological specificity factor MinE; Provisional; Region: PRK13989 395495000099 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 395495000100 active site 395495000101 catalytic residues [active] 395495000102 metal binding site [ion binding]; metal-binding site 395495000103 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495000104 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495000105 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495000106 putative acyltransferase; Provisional; Region: PRK05790 395495000107 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495000108 dimer interface [polypeptide binding]; other site 395495000109 active site 395495000110 6-phosphofructokinase; Provisional; Region: PRK14072 395495000111 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 395495000112 active site 395495000113 ADP/pyrophosphate binding site [chemical binding]; other site 395495000114 allosteric effector site; other site 395495000115 dimerization interface [polypeptide binding]; other site 395495000116 fructose-1,6-bisphosphate binding site; other site 395495000117 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 395495000118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495000119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495000120 DNA binding site [nucleotide binding] 395495000121 Predicted integral membrane protein [Function unknown]; Region: COG5616 395495000122 Response regulator receiver domain; Region: Response_reg; pfam00072 395495000123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000124 active site 395495000125 phosphorylation site [posttranslational modification] 395495000126 intermolecular recognition site; other site 395495000127 dimerization interface [polypeptide binding]; other site 395495000128 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395495000129 cyclase homology domain; Region: CHD; cd07302 395495000130 nucleotidyl binding site; other site 395495000131 metal binding site [ion binding]; metal-binding site 395495000132 dimer interface [polypeptide binding]; other site 395495000133 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000135 active site 395495000136 phosphorylation site [posttranslational modification] 395495000137 intermolecular recognition site; other site 395495000138 dimerization interface [polypeptide binding]; other site 395495000139 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 395495000140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495000141 dimerization interface [polypeptide binding]; other site 395495000142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495000143 dimer interface [polypeptide binding]; other site 395495000144 phosphorylation site [posttranslational modification] 395495000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000146 ATP binding site [chemical binding]; other site 395495000147 Mg2+ binding site [ion binding]; other site 395495000148 G-X-G motif; other site 395495000149 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495000150 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495000151 Cu(I) binding site [ion binding]; other site 395495000152 NMT1-like family; Region: NMT1_2; pfam13379 395495000153 NMT1/THI5 like; Region: NMT1; pfam09084 395495000154 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 395495000155 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 395495000156 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 395495000157 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395495000158 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 395495000159 heme-binding site [chemical binding]; other site 395495000160 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 395495000161 dimer interface [polypeptide binding]; other site 395495000162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000163 ATP binding site [chemical binding]; other site 395495000164 Mg2+ binding site [ion binding]; other site 395495000165 G-X-G motif; other site 395495000166 Cache domain; Region: Cache_1; pfam02743 395495000167 HAMP domain; Region: HAMP; pfam00672 395495000168 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 395495000169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395495000170 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495000171 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 395495000172 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395495000173 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395495000174 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 395495000175 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 395495000176 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 395495000177 catalytic residues [active] 395495000178 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395495000179 SlyX; Region: SlyX; pfam04102 395495000180 Cytochrome c [Energy production and conversion]; Region: COG3258 395495000181 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 395495000182 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 395495000183 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 395495000184 Cytochrome c; Region: Cytochrom_C; cl11414 395495000185 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 395495000186 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495000187 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 395495000188 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495000189 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 395495000190 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495000191 catalytic loop [active] 395495000192 iron binding site [ion binding]; other site 395495000193 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395495000194 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395495000195 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 395495000196 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395495000197 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495000198 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495000199 Cu(I) binding site [ion binding]; other site 395495000200 Chromate transporter; Region: Chromate_transp; pfam02417 395495000201 Chromate transporter; Region: Chromate_transp; pfam02417 395495000202 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395495000203 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 395495000204 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 395495000205 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 395495000206 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 395495000207 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 395495000208 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 395495000209 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 395495000210 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 395495000211 Coenzyme A transferase; Region: CoA_trans; cl17247 395495000212 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495000213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495000214 DNA-binding site [nucleotide binding]; DNA binding site 395495000215 Transcriptional regulators [Transcription]; Region: GntR; COG1802 395495000216 FCD domain; Region: FCD; pfam07729 395495000217 aminotransferase; Validated; Region: PRK08175 395495000218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495000219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495000220 homodimer interface [polypeptide binding]; other site 395495000221 catalytic residue [active] 395495000222 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 395495000223 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 395495000224 putative catalytic residue [active] 395495000225 Restriction endonuclease; Region: Mrr_cat; pfam04471 395495000226 Leucine rich repeat; Region: LRR_8; pfam13855 395495000227 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 395495000228 Leucine rich repeat; Region: LRR_8; pfam13855 395495000229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495000230 active site 395495000231 ATP binding site [chemical binding]; other site 395495000232 substrate binding site [chemical binding]; other site 395495000233 activation loop (A-loop); other site 395495000234 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 395495000235 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 395495000236 dimer interface [polypeptide binding]; other site 395495000237 active site 395495000238 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395495000239 substrate binding site [chemical binding]; other site 395495000240 catalytic residue [active] 395495000241 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 395495000242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495000243 Walker A motif; other site 395495000244 ATP binding site [chemical binding]; other site 395495000245 Walker B motif; other site 395495000246 arginine finger; other site 395495000247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495000248 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395495000249 active site residue [active] 395495000250 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395495000251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495000252 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 395495000253 DTW domain; Region: DTW; cl01221 395495000254 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395495000255 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495000256 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495000257 active site 395495000258 catalytic tetrad [active] 395495000259 Predicted membrane protein [Function unknown]; Region: COG2119 395495000260 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395495000261 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 395495000262 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 395495000263 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 395495000264 glutaminase active site [active] 395495000265 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 395495000266 dimer interface [polypeptide binding]; other site 395495000267 active site 395495000268 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 395495000269 dimer interface [polypeptide binding]; other site 395495000270 active site 395495000271 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495000272 putative DNA binding site [nucleotide binding]; other site 395495000273 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 395495000274 putative Zn2+ binding site [ion binding]; other site 395495000275 AsnC family; Region: AsnC_trans_reg; pfam01037 395495000276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 395495000277 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 395495000278 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 395495000279 Substrate binding site; other site 395495000280 Mg++ binding site; other site 395495000281 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 395495000282 active site 395495000283 substrate binding site [chemical binding]; other site 395495000284 CoA binding site [chemical binding]; other site 395495000285 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 395495000286 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 395495000287 Ligand Binding Site [chemical binding]; other site 395495000288 Dihydroneopterin aldolase; Region: FolB; smart00905 395495000289 active site 395495000290 short chain dehydrogenase; Provisional; Region: PRK09134 395495000291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495000292 NAD(P) binding site [chemical binding]; other site 395495000293 active site 395495000294 Uncharacterized conserved protein [Function unknown]; Region: COG1565 395495000295 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 395495000296 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 395495000297 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 395495000298 active site 395495000299 NTP binding site [chemical binding]; other site 395495000300 metal binding triad [ion binding]; metal-binding site 395495000301 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 395495000302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495000303 Zn2+ binding site [ion binding]; other site 395495000304 Mg2+ binding site [ion binding]; other site 395495000305 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 395495000306 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395495000307 putative C-terminal domain interface [polypeptide binding]; other site 395495000308 putative GSH binding site (G-site) [chemical binding]; other site 395495000309 putative dimer interface [polypeptide binding]; other site 395495000310 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 395495000311 putative substrate binding pocket (H-site) [chemical binding]; other site 395495000312 putative N-terminal domain interface [polypeptide binding]; other site 395495000313 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495000314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000315 active site 395495000316 phosphorylation site [posttranslational modification] 395495000317 intermolecular recognition site; other site 395495000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495000319 Walker A motif; other site 395495000320 ATP binding site [chemical binding]; other site 395495000321 Walker B motif; other site 395495000322 arginine finger; other site 395495000323 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495000324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495000325 dimer interface [polypeptide binding]; other site 395495000326 phosphorylation site [posttranslational modification] 395495000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000328 ATP binding site [chemical binding]; other site 395495000329 G-X-G motif; other site 395495000330 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 395495000331 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 395495000332 putative NAD(P) binding site [chemical binding]; other site 395495000333 active site 395495000334 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 395495000335 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495000336 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495000337 catalytic residue [active] 395495000338 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 395495000339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495000340 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 395495000341 dimerization interface [polypeptide binding]; other site 395495000342 substrate binding pocket [chemical binding]; other site 395495000343 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 395495000344 TfoX N-terminal domain; Region: TfoX_N; pfam04993 395495000345 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 395495000346 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 395495000347 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 395495000348 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 395495000349 FAD binding site [chemical binding]; other site 395495000350 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 395495000351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495000352 RNA binding surface [nucleotide binding]; other site 395495000353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495000354 S-adenosylmethionine binding site [chemical binding]; other site 395495000355 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 395495000356 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 395495000357 homotetramer interface [polypeptide binding]; other site 395495000358 ligand binding site [chemical binding]; other site 395495000359 catalytic site [active] 395495000360 NAD binding site [chemical binding]; other site 395495000361 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 395495000362 active site 395495000363 ProQ/FINO family; Region: ProQ; pfam04352 395495000364 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 395495000365 ATP-grasp domain; Region: ATP-grasp; pfam02222 395495000366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 395495000367 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 395495000368 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 395495000369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 395495000370 S-adenosylmethionine synthetase; Validated; Region: PRK05250 395495000371 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 395495000372 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 395495000373 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 395495000374 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 395495000375 putative acyl-acceptor binding pocket; other site 395495000376 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 395495000377 putative acyl-acceptor binding pocket; other site 395495000378 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 395495000379 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 395495000380 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 395495000381 Protein of unknown function, DUF484; Region: DUF484; cl17449 395495000382 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 395495000383 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495000384 active site 395495000385 DNA binding site [nucleotide binding] 395495000386 Int/Topo IB signature motif; other site 395495000387 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 395495000388 N- and C-terminal domain interface [polypeptide binding]; other site 395495000389 D-xylulose kinase; Region: XylB; TIGR01312 395495000390 active site 395495000391 MgATP binding site [chemical binding]; other site 395495000392 catalytic site [active] 395495000393 metal binding site [ion binding]; metal-binding site 395495000394 xylulose binding site [chemical binding]; other site 395495000395 homodimer interface [polypeptide binding]; other site 395495000396 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 395495000397 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 395495000398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495000399 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 395495000400 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 395495000401 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 395495000402 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 395495000403 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495000404 Walker A/P-loop; other site 395495000405 ATP binding site [chemical binding]; other site 395495000406 Q-loop/lid; other site 395495000407 ABC transporter signature motif; other site 395495000408 Walker B; other site 395495000409 D-loop; other site 395495000410 H-loop/switch region; other site 395495000411 TOBE domain; Region: TOBE_2; pfam08402 395495000412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495000414 dimer interface [polypeptide binding]; other site 395495000415 conserved gate region; other site 395495000416 ABC-ATPase subunit interface; other site 395495000417 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395495000418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495000419 dimer interface [polypeptide binding]; other site 395495000420 conserved gate region; other site 395495000421 putative PBP binding loops; other site 395495000422 ABC-ATPase subunit interface; other site 395495000423 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395495000424 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495000425 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 395495000426 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 395495000427 putative RNA binding site [nucleotide binding]; other site 395495000428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495000429 S-adenosylmethionine binding site [chemical binding]; other site 395495000430 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495000431 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495000432 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 395495000433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395495000434 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395495000435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495000436 motif II; other site 395495000437 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 395495000438 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 395495000439 Domain of unknown function (DUF336); Region: DUF336; cl01249 395495000440 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 395495000441 transcriptional activator FlhC; Provisional; Region: PRK12722 395495000442 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 395495000443 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 395495000444 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 395495000445 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 395495000446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495000447 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 395495000448 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 395495000449 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 395495000450 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395495000451 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 395495000452 Nitrogen regulatory protein P-II; Region: P-II; smart00938 395495000453 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 395495000454 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395495000455 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 395495000456 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 395495000457 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 395495000458 N-formylglutamate amidohydrolase; Region: FGase; cl01522 395495000459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495000460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495000461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395495000462 dimerization interface [polypeptide binding]; other site 395495000463 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 395495000464 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395495000465 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 395495000466 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495000467 Ligand binding site [chemical binding]; other site 395495000468 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495000469 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495000470 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495000471 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495000472 HutD; Region: HutD; pfam05962 395495000473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395495000474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395495000475 non-specific DNA binding site [nucleotide binding]; other site 395495000476 salt bridge; other site 395495000477 sequence-specific DNA binding site [nucleotide binding]; other site 395495000478 Cupin domain; Region: Cupin_2; pfam07883 395495000479 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 395495000480 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395495000481 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395495000482 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 395495000483 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 395495000484 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 395495000485 active site 395495000486 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 395495000487 domain_subunit interface; other site 395495000488 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 395495000489 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 395495000490 active site 395495000491 FMN binding site [chemical binding]; other site 395495000492 substrate binding site [chemical binding]; other site 395495000493 3Fe-4S cluster binding site [ion binding]; other site 395495000494 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395495000495 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 395495000496 FMN-binding pocket [chemical binding]; other site 395495000497 flavin binding motif; other site 395495000498 phosphate binding motif [ion binding]; other site 395495000499 beta-alpha-beta structure motif; other site 395495000500 NAD binding pocket [chemical binding]; other site 395495000501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495000502 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495000503 catalytic loop [active] 395495000504 iron binding site [ion binding]; other site 395495000505 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 395495000506 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 395495000507 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395495000508 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 395495000509 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 395495000510 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 395495000511 putative active site [active] 395495000512 putative substrate binding site [chemical binding]; other site 395495000513 putative cosubstrate binding site; other site 395495000514 catalytic site [active] 395495000515 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 395495000516 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 395495000517 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 395495000518 homodimer interface [polypeptide binding]; other site 395495000519 NADP binding site [chemical binding]; other site 395495000520 substrate binding site [chemical binding]; other site 395495000521 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 395495000522 Transglycosylase; Region: Transgly; pfam00912 395495000523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395495000524 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 395495000525 nitrite reductase subunit NirD; Provisional; Region: PRK14989 395495000526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495000527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495000528 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495000529 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495000530 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395495000531 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495000532 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495000533 ligand binding site [chemical binding]; other site 395495000534 flexible hinge region; other site 395495000535 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 395495000536 aromatic arch; other site 395495000537 DCoH dimer interaction site [polypeptide binding]; other site 395495000538 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395495000539 DCoH tetramer interaction site [polypeptide binding]; other site 395495000540 substrate binding site [chemical binding]; other site 395495000541 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 395495000542 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395495000543 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 395495000544 TrkA-N domain; Region: TrkA_N; pfam02254 395495000545 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 395495000546 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 395495000547 putative active site [active] 395495000548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 395495000549 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395495000550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 395495000551 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 395495000552 short chain dehydrogenase; Provisional; Region: PRK07024 395495000553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495000554 NAD(P) binding site [chemical binding]; other site 395495000555 active site 395495000556 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 395495000557 MarC family integral membrane protein; Region: MarC; cl00919 395495000558 choline dehydrogenase; Validated; Region: PRK02106 395495000559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395495000560 hypothetical protein; Provisional; Region: PRK10621 395495000561 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495000562 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 395495000563 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395495000564 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395495000565 phosphopeptide binding site; other site 395495000566 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395495000567 active site 395495000568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495000569 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495000570 active site 395495000571 ATP binding site [chemical binding]; other site 395495000572 substrate binding site [chemical binding]; other site 395495000573 activation loop (A-loop); other site 395495000574 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 395495000575 SWIB/MDM2 domain; Region: SWIB; pfam02201 395495000576 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 395495000577 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 395495000578 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 395495000579 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 395495000580 ParB-like nuclease domain; Region: ParB; smart00470 395495000581 PrkA family serine protein kinase; Provisional; Region: PRK15455 395495000582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495000583 Walker A motif; other site 395495000584 ATP binding site [chemical binding]; other site 395495000585 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 395495000586 hypothetical protein; Provisional; Region: PRK05325 395495000587 SpoVR family protein; Provisional; Region: PRK11767 395495000588 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 395495000589 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395495000590 FAD binding domain; Region: FAD_binding_4; pfam01565 395495000591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495000592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495000593 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495000594 non-specific DNA interactions [nucleotide binding]; other site 395495000595 DNA binding site [nucleotide binding] 395495000596 sequence specific DNA binding site [nucleotide binding]; other site 395495000597 putative cAMP binding site [chemical binding]; other site 395495000598 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 395495000599 Transcriptional regulators [Transcription]; Region: GntR; COG1802 395495000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495000601 DNA-binding site [nucleotide binding]; DNA binding site 395495000602 FCD domain; Region: FCD; pfam07729 395495000603 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395495000604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495000605 dimer interface [polypeptide binding]; other site 395495000606 conserved gate region; other site 395495000607 putative PBP binding loops; other site 395495000608 ABC-ATPase subunit interface; other site 395495000609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495000610 dimer interface [polypeptide binding]; other site 395495000611 conserved gate region; other site 395495000612 putative PBP binding loops; other site 395495000613 ABC-ATPase subunit interface; other site 395495000614 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395495000615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395495000616 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 395495000617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495000618 Walker A/P-loop; other site 395495000619 ATP binding site [chemical binding]; other site 395495000620 Q-loop/lid; other site 395495000621 ABC transporter signature motif; other site 395495000622 Walker B; other site 395495000623 D-loop; other site 395495000624 H-loop/switch region; other site 395495000625 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 395495000626 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 395495000627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495000628 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 395495000629 putative active site [active] 395495000630 heme pocket [chemical binding]; other site 395495000631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495000632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495000633 putative active site [active] 395495000634 heme pocket [chemical binding]; other site 395495000635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495000636 dimer interface [polypeptide binding]; other site 395495000637 phosphorylation site [posttranslational modification] 395495000638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000639 ATP binding site [chemical binding]; other site 395495000640 Mg2+ binding site [ion binding]; other site 395495000641 G-X-G motif; other site 395495000642 Protein of unknown function DUF45; Region: DUF45; pfam01863 395495000643 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395495000644 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395495000645 putative acyl-acceptor binding pocket; other site 395495000646 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 395495000647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495000648 active site 395495000649 motif I; other site 395495000650 motif II; other site 395495000651 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 395495000652 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 395495000653 dimer interface [polypeptide binding]; other site 395495000654 motif 1; other site 395495000655 active site 395495000656 motif 2; other site 395495000657 motif 3; other site 395495000658 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 395495000659 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 395495000660 Substrate binding site; other site 395495000661 metal-binding site 395495000662 Hemerythrin-like domain; Region: Hr-like; cd12108 395495000663 Fe binding site [ion binding]; other site 395495000664 transketolase; Reviewed; Region: PRK12753 395495000665 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395495000666 TPP-binding site [chemical binding]; other site 395495000667 dimer interface [polypeptide binding]; other site 395495000668 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395495000669 PYR/PP interface [polypeptide binding]; other site 395495000670 dimer interface [polypeptide binding]; other site 395495000671 TPP binding site [chemical binding]; other site 395495000672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395495000673 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 395495000674 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 395495000675 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 395495000676 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 395495000677 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 395495000678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 395495000679 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 395495000680 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 395495000681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 395495000682 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 395495000683 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 395495000684 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 395495000685 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 395495000686 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 395495000687 Proteins containing SET domain [General function prediction only]; Region: COG2940 395495000688 SET domain; Region: SET; pfam00856 395495000689 DNA topoisomerase III; Validated; Region: PRK08173 395495000690 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 395495000691 active site 395495000692 putative interdomain interaction site [polypeptide binding]; other site 395495000693 putative metal-binding site [ion binding]; other site 395495000694 putative nucleotide binding site [chemical binding]; other site 395495000695 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 395495000696 domain I; other site 395495000697 DNA binding groove [nucleotide binding] 395495000698 phosphate binding site [ion binding]; other site 395495000699 domain II; other site 395495000700 domain III; other site 395495000701 nucleotide binding site [chemical binding]; other site 395495000702 catalytic site [active] 395495000703 domain IV; other site 395495000704 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 395495000705 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 395495000706 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 395495000707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495000708 Zn2+ binding site [ion binding]; other site 395495000709 Mg2+ binding site [ion binding]; other site 395495000710 Membrane transport protein; Region: Mem_trans; cl09117 395495000711 PIN domain; Region: PIN_3; pfam13470 395495000712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495000713 putative substrate translocation pore; other site 395495000714 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 395495000715 Na binding site [ion binding]; other site 395495000716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495000717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495000718 dimer interface [polypeptide binding]; other site 395495000719 phosphorylation site [posttranslational modification] 395495000720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000721 ATP binding site [chemical binding]; other site 395495000722 Mg2+ binding site [ion binding]; other site 395495000723 G-X-G motif; other site 395495000724 Response regulator receiver domain; Region: Response_reg; pfam00072 395495000725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000726 active site 395495000727 phosphorylation site [posttranslational modification] 395495000728 intermolecular recognition site; other site 395495000729 dimerization interface [polypeptide binding]; other site 395495000730 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 395495000731 active site 395495000732 catalytic site [active] 395495000733 substrate binding site [chemical binding]; other site 395495000734 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 395495000735 putative deacylase active site [active] 395495000736 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 395495000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495000738 putative substrate translocation pore; other site 395495000739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495000740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000741 active site 395495000742 phosphorylation site [posttranslational modification] 395495000743 intermolecular recognition site; other site 395495000744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495000745 DNA binding residues [nucleotide binding] 395495000746 dimerization interface [polypeptide binding]; other site 395495000747 HAMP domain; Region: HAMP; pfam00672 395495000748 Histidine kinase; Region: HisKA_3; pfam07730 395495000749 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 395495000750 Mg2+ binding site [ion binding]; other site 395495000751 G-X-G motif; other site 395495000752 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 395495000753 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 395495000754 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 395495000755 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 395495000756 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 395495000757 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 395495000758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495000759 FeS/SAM binding site; other site 395495000760 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 395495000761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495000762 Ligand Binding Site [chemical binding]; other site 395495000763 Predicted small integral membrane protein [Function unknown]; Region: COG5605 395495000764 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 395495000765 Subunit I/III interface [polypeptide binding]; other site 395495000766 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 395495000767 Subunit I/III interface [polypeptide binding]; other site 395495000768 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 395495000769 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 395495000770 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 395495000771 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 395495000772 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 395495000773 putative deacylase active site [active] 395495000774 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 395495000775 peroxiredoxin; Region: AhpC; TIGR03137 395495000776 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 395495000777 dimer interface [polypeptide binding]; other site 395495000778 decamer (pentamer of dimers) interface [polypeptide binding]; other site 395495000779 catalytic triad [active] 395495000780 peroxidatic and resolving cysteines [active] 395495000781 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 395495000782 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 395495000783 catalytic residue [active] 395495000784 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 395495000785 catalytic residues [active] 395495000786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495000787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495000788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495000789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495000790 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495000791 putative effector binding pocket; other site 395495000792 dimerization interface [polypeptide binding]; other site 395495000793 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 395495000794 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 395495000795 catalytic residues [active] 395495000796 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395495000797 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 395495000798 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 395495000799 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 395495000800 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 395495000801 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 395495000802 enoyl-CoA hydratase; Provisional; Region: PRK05862 395495000803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495000804 substrate binding site [chemical binding]; other site 395495000805 oxyanion hole (OAH) forming residues; other site 395495000806 trimer interface [polypeptide binding]; other site 395495000807 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 395495000808 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 395495000809 dimerization domain [polypeptide binding]; other site 395495000810 dimer interface [polypeptide binding]; other site 395495000811 catalytic residues [active] 395495000812 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495000813 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 395495000814 Phage Tail Collar Domain; Region: Collar; pfam07484 395495000815 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 395495000816 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 395495000817 MOSC domain; Region: MOSC; pfam03473 395495000818 GTP-binding protein YchF; Reviewed; Region: PRK09601 395495000819 YchF GTPase; Region: YchF; cd01900 395495000820 G1 box; other site 395495000821 GTP/Mg2+ binding site [chemical binding]; other site 395495000822 Switch I region; other site 395495000823 G2 box; other site 395495000824 Switch II region; other site 395495000825 G3 box; other site 395495000826 G4 box; other site 395495000827 G5 box; other site 395495000828 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 395495000829 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395495000830 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395495000831 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395495000832 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 395495000833 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495000834 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495000835 protein binding site [polypeptide binding]; other site 395495000836 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495000837 protein binding site [polypeptide binding]; other site 395495000838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495000839 dimer interface [polypeptide binding]; other site 395495000840 phosphorylation site [posttranslational modification] 395495000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495000842 ATP binding site [chemical binding]; other site 395495000843 Mg2+ binding site [ion binding]; other site 395495000844 G-X-G motif; other site 395495000845 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495000846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495000847 active site 395495000848 phosphorylation site [posttranslational modification] 395495000849 intermolecular recognition site; other site 395495000850 dimerization interface [polypeptide binding]; other site 395495000851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495000852 DNA binding site [nucleotide binding] 395495000853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495000854 putative DNA binding site [nucleotide binding]; other site 395495000855 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 395495000856 putative Zn2+ binding site [ion binding]; other site 395495000857 AsnC family; Region: AsnC_trans_reg; pfam01037 395495000858 ornithine cyclodeaminase; Validated; Region: PRK07589 395495000859 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 395495000860 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 395495000861 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 395495000862 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 395495000863 dimer interface [polypeptide binding]; other site 395495000864 active site 395495000865 heme binding site [chemical binding]; other site 395495000866 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 395495000867 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 395495000868 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 395495000869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495000870 Zn2+ binding site [ion binding]; other site 395495000871 Mg2+ binding site [ion binding]; other site 395495000872 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 395495000873 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 395495000874 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 395495000875 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 395495000876 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495000877 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 395495000878 homotrimer interaction site [polypeptide binding]; other site 395495000879 putative active site [active] 395495000880 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 395495000881 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 395495000882 dimer interface [polypeptide binding]; other site 395495000883 putative anticodon binding site; other site 395495000884 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 395495000885 motif 1; other site 395495000886 active site 395495000887 motif 2; other site 395495000888 motif 3; other site 395495000889 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495000890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495000891 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495000892 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 395495000893 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 395495000894 putative trimer interface [polypeptide binding]; other site 395495000895 putative active site [active] 395495000896 putative substrate binding site [chemical binding]; other site 395495000897 putative CoA binding site [chemical binding]; other site 395495000898 AAA domain; Region: AAA_21; pfam13304 395495000899 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395495000900 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495000901 inhibitor-cofactor binding pocket; inhibition site 395495000902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495000903 catalytic residue [active] 395495000904 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 395495000905 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 395495000906 trimer interface [polypeptide binding]; other site 395495000907 active site 395495000908 substrate binding site [chemical binding]; other site 395495000909 CoA binding site [chemical binding]; other site 395495000910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495000911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495000912 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 395495000913 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 395495000914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495000915 S-adenosylmethionine binding site [chemical binding]; other site 395495000916 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395495000917 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495000918 inhibitor-cofactor binding pocket; inhibition site 395495000919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495000920 catalytic residue [active] 395495000921 Bacterial sugar transferase; Region: Bac_transf; pfam02397 395495000922 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 395495000923 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 395495000924 NAD(P) binding site [chemical binding]; other site 395495000925 homodimer interface [polypeptide binding]; other site 395495000926 substrate binding site [chemical binding]; other site 395495000927 active site 395495000928 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395495000929 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 395495000930 active site 395495000931 nucleophile elbow; other site 395495000932 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 395495000933 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 395495000934 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 395495000935 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 395495000936 Pirin-related protein [General function prediction only]; Region: COG1741 395495000937 Pirin; Region: Pirin; pfam02678 395495000938 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 395495000939 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 395495000940 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 395495000941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495000942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495000943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495000944 putative effector binding pocket; other site 395495000945 dimerization interface [polypeptide binding]; other site 395495000946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495000947 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 395495000948 C-terminal domain interface [polypeptide binding]; other site 395495000949 GSH binding site (G-site) [chemical binding]; other site 395495000950 dimer interface [polypeptide binding]; other site 395495000951 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 395495000952 N-terminal domain interface [polypeptide binding]; other site 395495000953 dimer interface [polypeptide binding]; other site 395495000954 substrate binding pocket (H-site) [chemical binding]; other site 395495000955 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395495000956 HDOD domain; Region: HDOD; pfam08668 395495000957 hypothetical protein; Validated; Region: PRK07198 395495000958 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 395495000959 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395495000960 dimerization interface [polypeptide binding]; other site 395495000961 active site 395495000962 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 395495000963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495000964 active site 395495000965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395495000966 phosphate binding site [ion binding]; other site 395495000967 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495000968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495000969 metal binding site [ion binding]; metal-binding site 395495000970 active site 395495000971 I-site; other site 395495000972 cytosine deaminase; Validated; Region: PRK07572 395495000973 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 395495000974 active site 395495000975 putative glutathione S-transferase; Provisional; Region: PRK10357 395495000976 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395495000977 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 395495000978 dimer interface [polypeptide binding]; other site 395495000979 N-terminal domain interface [polypeptide binding]; other site 395495000980 putative substrate binding pocket (H-site) [chemical binding]; other site 395495000981 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 395495000982 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 395495000983 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 395495000984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495000985 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 395495000986 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 395495000987 hypothetical protein; Provisional; Region: PRK08201 395495000988 metal binding site [ion binding]; metal-binding site 395495000989 putative dimer interface [polypeptide binding]; other site 395495000990 Predicted permeases [General function prediction only]; Region: COG0679 395495000991 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495000992 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495000993 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 395495000994 ATP-binding site [chemical binding]; other site 395495000995 Gluconate-6-phosphate binding site [chemical binding]; other site 395495000996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495000997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495000998 DNA binding site [nucleotide binding] 395495000999 domain linker motif; other site 395495001000 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 395495001001 putative ligand binding site [chemical binding]; other site 395495001002 putative dimerization interface [polypeptide binding]; other site 395495001003 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 395495001004 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 395495001005 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 395495001006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495001007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495001008 metal binding site [ion binding]; metal-binding site 395495001009 active site 395495001010 I-site; other site 395495001011 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495001012 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395495001013 anti sigma factor interaction site; other site 395495001014 regulatory phosphorylation site [posttranslational modification]; other site 395495001015 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395495001016 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495001017 putative binding surface; other site 395495001018 active site 395495001019 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395495001020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495001021 ATP binding site [chemical binding]; other site 395495001022 Mg2+ binding site [ion binding]; other site 395495001023 G-X-G motif; other site 395495001024 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395495001025 PAS domain; Region: PAS_9; pfam13426 395495001026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495001027 putative active site [active] 395495001028 heme pocket [chemical binding]; other site 395495001029 PAS domain; Region: PAS_9; pfam13426 395495001030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495001031 putative active site [active] 395495001032 heme pocket [chemical binding]; other site 395495001033 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495001034 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 395495001035 dimer interface [polypeptide binding]; other site 395495001036 putative CheW interface [polypeptide binding]; other site 395495001037 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 395495001038 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 395495001039 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 395495001040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495001041 CheD chemotactic sensory transduction; Region: CheD; cl00810 395495001042 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 395495001043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495001044 active site 395495001045 phosphorylation site [posttranslational modification] 395495001046 intermolecular recognition site; other site 395495001047 CheB methylesterase; Region: CheB_methylest; pfam01339 395495001048 NnrU protein; Region: NnrU; pfam07298 395495001049 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 395495001050 Part of AAA domain; Region: AAA_19; pfam13245 395495001051 Family description; Region: UvrD_C_2; pfam13538 395495001052 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 395495001053 active site 395495001054 catalytic triad [active] 395495001055 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 395495001056 active site 395495001057 catalytic triad [active] 395495001058 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 395495001059 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495001060 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 395495001061 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 395495001062 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 395495001063 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 395495001064 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 395495001065 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 395495001066 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 395495001067 Protein export membrane protein; Region: SecD_SecF; pfam02355 395495001068 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 395495001069 Protein of unknown function (DUF494); Region: DUF494; pfam04361 395495001070 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 395495001071 DNA protecting protein DprA; Region: dprA; TIGR00732 395495001072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395495001073 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 395495001074 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 395495001075 active site 395495001076 catalytic residues [active] 395495001077 metal binding site [ion binding]; metal-binding site 395495001078 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 395495001079 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 395495001080 putative active site [active] 395495001081 substrate binding site [chemical binding]; other site 395495001082 putative cosubstrate binding site; other site 395495001083 catalytic site [active] 395495001084 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 395495001085 substrate binding site [chemical binding]; other site 395495001086 AzlC protein; Region: AzlC; pfam03591 395495001087 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 395495001088 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 395495001089 Phosphoglycerate kinase; Region: PGK; pfam00162 395495001090 substrate binding site [chemical binding]; other site 395495001091 hinge regions; other site 395495001092 ADP binding site [chemical binding]; other site 395495001093 catalytic site [active] 395495001094 LabA_like proteins; Region: LabA_like/DUF88; cl10034 395495001095 putative metal binding site [ion binding]; other site 395495001096 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 395495001097 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395495001098 active site 395495001099 NTP binding site [chemical binding]; other site 395495001100 metal binding triad [ion binding]; metal-binding site 395495001101 antibiotic binding site [chemical binding]; other site 395495001102 Protein of unknown function DUF86; Region: DUF86; cl01031 395495001103 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 395495001104 Malic enzyme, N-terminal domain; Region: malic; pfam00390 395495001105 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 395495001106 putative NAD(P) binding site [chemical binding]; other site 395495001107 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 395495001108 pyruvate kinase; Provisional; Region: PRK05826 395495001109 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 395495001110 domain interfaces; other site 395495001111 active site 395495001112 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 395495001113 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 395495001114 intersubunit interface [polypeptide binding]; other site 395495001115 active site 395495001116 zinc binding site [ion binding]; other site 395495001117 Na+ binding site [ion binding]; other site 395495001118 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 395495001119 active site 395495001120 ATP binding site [chemical binding]; other site 395495001121 substrate binding site [chemical binding]; other site 395495001122 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 395495001123 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 395495001124 AIR carboxylase; Region: AIRC; pfam00731 395495001125 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 395495001126 ATP-grasp domain; Region: ATP-grasp; pfam02222 395495001127 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 395495001128 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 395495001129 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 395495001130 active site 395495001131 catalytic triad [active] 395495001132 oxyanion hole [active] 395495001133 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 395495001134 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 395495001135 Glycoprotease family; Region: Peptidase_M22; pfam00814 395495001136 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 395495001137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495001138 Coenzyme A binding pocket [chemical binding]; other site 395495001139 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 395495001140 Fe-S cluster binding site [ion binding]; other site 395495001141 active site 395495001142 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 395495001143 oligomer interface [polypeptide binding]; other site 395495001144 metal binding site [ion binding]; metal-binding site 395495001145 metal binding site [ion binding]; metal-binding site 395495001146 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 395495001147 putative Cl binding site [ion binding]; other site 395495001148 aspartate ring; other site 395495001149 basic sphincter; other site 395495001150 hydrophobic gate; other site 395495001151 periplasmic entrance; other site 395495001152 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 395495001153 dimer interface [polypeptide binding]; other site 395495001154 allosteric magnesium binding site [ion binding]; other site 395495001155 active site 395495001156 aspartate-rich active site metal binding site; other site 395495001157 Schiff base residues; other site 395495001158 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 395495001159 signal recognition particle protein; Provisional; Region: PRK10867 395495001160 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 395495001161 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 395495001162 GTP binding site [chemical binding]; other site 395495001163 Signal peptide binding domain; Region: SRP_SPB; pfam02978 395495001164 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 395495001165 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395495001166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495001167 dimer interface [polypeptide binding]; other site 395495001168 phosphorylation site [posttranslational modification] 395495001169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495001170 ATP binding site [chemical binding]; other site 395495001171 Mg2+ binding site [ion binding]; other site 395495001172 G-X-G motif; other site 395495001173 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495001175 active site 395495001176 phosphorylation site [posttranslational modification] 395495001177 intermolecular recognition site; other site 395495001178 dimerization interface [polypeptide binding]; other site 395495001179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495001180 Walker A motif; other site 395495001181 ATP binding site [chemical binding]; other site 395495001182 Walker B motif; other site 395495001183 arginine finger; other site 395495001184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495001185 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 395495001186 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 395495001187 amidase catalytic site [active] 395495001188 Zn binding residues [ion binding]; other site 395495001189 substrate binding site [chemical binding]; other site 395495001190 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 395495001191 ATP cone domain; Region: ATP-cone; pfam03477 395495001192 Class I ribonucleotide reductase; Region: RNR_I; cd01679 395495001193 active site 395495001194 dimer interface [polypeptide binding]; other site 395495001195 catalytic residues [active] 395495001196 effector binding site; other site 395495001197 R2 peptide binding site; other site 395495001198 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 395495001199 dimer interface [polypeptide binding]; other site 395495001200 putative radical transfer pathway; other site 395495001201 diiron center [ion binding]; other site 395495001202 tyrosyl radical; other site 395495001203 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 395495001204 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395495001205 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 395495001206 substrate binding site [chemical binding]; other site 395495001207 ATP binding site [chemical binding]; other site 395495001208 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495001209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495001210 metal binding site [ion binding]; metal-binding site 395495001211 active site 395495001212 I-site; other site 395495001213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495001214 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 395495001215 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 395495001216 putative active site [active] 395495001217 putative dimer interface [polypeptide binding]; other site 395495001218 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 395495001219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495001220 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395495001221 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 395495001222 active site 395495001223 nucleophile elbow; other site 395495001224 Surface antigen; Region: Bac_surface_Ag; pfam01103 395495001225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495001226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495001227 DNA binding site [nucleotide binding] 395495001228 domain linker motif; other site 395495001229 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 395495001230 putative dimerization interface [polypeptide binding]; other site 395495001231 putative ligand binding site [chemical binding]; other site 395495001232 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 395495001233 G1 box; other site 395495001234 GTP/Mg2+ binding site [chemical binding]; other site 395495001235 Switch I region; other site 395495001236 G2 box; other site 395495001237 G3 box; other site 395495001238 Switch II region; other site 395495001239 G4 box; other site 395495001240 G5 box; other site 395495001241 Cytochrome c553 [Energy production and conversion]; Region: COG2863 395495001242 Cytochrome c; Region: Cytochrom_C; cl11414 395495001243 TMAO/DMSO reductase; Reviewed; Region: PRK05363 395495001244 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 395495001245 Moco binding site; other site 395495001246 metal coordination site [ion binding]; other site 395495001247 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 395495001248 Uncharacterized conserved protein [Function unknown]; Region: COG1284 395495001249 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 395495001250 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 395495001251 Sel1-like repeats; Region: SEL1; smart00671 395495001252 Sel1-like repeats; Region: SEL1; smart00671 395495001253 lipoate-protein ligase B; Provisional; Region: PRK14346 395495001254 lipoyl synthase; Provisional; Region: PRK05481 395495001255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495001256 FeS/SAM binding site; other site 395495001257 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 395495001258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495001259 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 395495001260 dimerization interface [polypeptide binding]; other site 395495001261 substrate binding pocket [chemical binding]; other site 395495001262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495001263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495001264 NAD(P) binding site [chemical binding]; other site 395495001265 active site 395495001266 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495001267 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495001268 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 395495001269 DctM-like transporters; Region: DctM; pfam06808 395495001270 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495001271 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 395495001272 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 395495001273 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495001274 DNA binding residues [nucleotide binding] 395495001275 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 395495001276 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 395495001277 dihydroxyacetone kinase; Provisional; Region: PRK14479 395495001278 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 395495001279 DAK2 domain; Region: Dak2; pfam02734 395495001280 transketolase; Reviewed; Region: PRK12753 395495001281 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395495001282 TPP-binding site [chemical binding]; other site 395495001283 dimer interface [polypeptide binding]; other site 395495001284 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395495001285 PYR/PP interface [polypeptide binding]; other site 395495001286 dimer interface [polypeptide binding]; other site 395495001287 TPP binding site [chemical binding]; other site 395495001288 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395495001289 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 395495001290 putative active site [active] 395495001291 transaldolase; Provisional; Region: PRK03903 395495001292 catalytic residue [active] 395495001293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495001294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495001295 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 395495001296 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 395495001297 DctM-like transporters; Region: DctM; pfam06808 395495001298 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495001299 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495001300 Dehydroquinase class II; Region: DHquinase_II; pfam01220 395495001301 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 395495001302 trimer interface [polypeptide binding]; other site 395495001303 active site 395495001304 dimer interface [polypeptide binding]; other site 395495001305 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395495001306 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 395495001307 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 395495001308 dimer interface [polypeptide binding]; other site 395495001309 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 395495001310 active site 395495001311 Fe binding site [ion binding]; other site 395495001312 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 395495001313 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395495001314 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395495001315 shikimate binding site; other site 395495001316 NAD(P) binding site [chemical binding]; other site 395495001317 FOG: CBS domain [General function prediction only]; Region: COG0517 395495001318 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 395495001319 Pirin-related protein [General function prediction only]; Region: COG1741 395495001320 Pirin; Region: Pirin; pfam02678 395495001321 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 395495001322 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 395495001323 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 395495001324 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 395495001325 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 395495001326 acyl-activating enzyme (AAE) consensus motif; other site 395495001327 putative AMP binding site [chemical binding]; other site 395495001328 putative active site [active] 395495001329 putative CoA binding site [chemical binding]; other site 395495001330 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 395495001331 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 395495001332 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 395495001333 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 395495001334 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 395495001335 ligand binding site [chemical binding]; other site 395495001336 homodimer interface [polypeptide binding]; other site 395495001337 NAD(P) binding site [chemical binding]; other site 395495001338 trimer interface B [polypeptide binding]; other site 395495001339 trimer interface A [polypeptide binding]; other site 395495001340 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 395495001341 nudix motif; other site 395495001342 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 395495001343 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495001344 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 395495001345 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 395495001346 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 395495001347 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 395495001348 Ligand Binding Site [chemical binding]; other site 395495001349 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 395495001350 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 395495001351 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495001352 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 395495001353 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495001354 Zn binding site [ion binding]; other site 395495001355 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 395495001356 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 395495001357 dimer interface [polypeptide binding]; other site 395495001358 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 395495001359 active site 395495001360 Fe binding site [ion binding]; other site 395495001361 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 395495001362 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 395495001363 trimer interface [polypeptide binding]; other site 395495001364 putative metal binding site [ion binding]; other site 395495001365 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495001366 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495001367 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495001368 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 395495001369 active site 395495001370 catalytic residues [active] 395495001371 metal binding site [ion binding]; metal-binding site 395495001372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495001373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495001374 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 395495001375 putative dimerization interface [polypeptide binding]; other site 395495001376 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 395495001377 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 395495001378 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495001379 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 395495001380 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395495001381 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 395495001382 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 395495001383 Sulfate transporter family; Region: Sulfate_transp; pfam00916 395495001384 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 395495001385 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395495001386 Serine hydrolase (FSH1); Region: FSH1; pfam03959 395495001387 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395495001388 active site 395495001389 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 395495001390 active site 395495001391 catalytic residues [active] 395495001392 metal binding site [ion binding]; metal-binding site 395495001393 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 395495001394 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 395495001395 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 395495001396 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 395495001397 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 395495001398 Sel1-like repeats; Region: SEL1; smart00671 395495001399 Sel1-like repeats; Region: SEL1; smart00671 395495001400 Sel1-like repeats; Region: SEL1; smart00671 395495001401 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 395495001402 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 395495001403 Chromate transporter; Region: Chromate_transp; pfam02417 395495001404 EamA-like transporter family; Region: EamA; pfam00892 395495001405 hypothetical protein; Provisional; Region: PRK02487 395495001406 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 395495001407 dimerization interface [polypeptide binding]; other site 395495001408 putative active cleft [active] 395495001409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495001410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495001411 DNA binding site [nucleotide binding] 395495001412 domain linker motif; other site 395495001413 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 395495001414 ligand binding site [chemical binding]; other site 395495001415 dimerization interface [polypeptide binding]; other site 395495001416 Uncharacterized conserved protein [Function unknown]; Region: COG2353 395495001417 YceI-like domain; Region: YceI; smart00867 395495001418 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 395495001419 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395495001420 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 395495001421 DNA binding residues [nucleotide binding] 395495001422 B12 binding domain; Region: B12-binding_2; pfam02607 395495001423 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395495001424 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 395495001425 catalytic residues [active] 395495001426 dimer interface [polypeptide binding]; other site 395495001427 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 395495001428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495001429 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 395495001430 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 395495001431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495001432 S-adenosylmethionine binding site [chemical binding]; other site 395495001433 MFS/sugar transport protein; Region: MFS_2; pfam13347 395495001434 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 395495001435 short chain dehydrogenase; Provisional; Region: PRK07024 395495001436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495001437 NAD(P) binding site [chemical binding]; other site 395495001438 active site 395495001439 SnoaL-like domain; Region: SnoaL_2; pfam12680 395495001440 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 395495001441 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 395495001442 Cl binding site [ion binding]; other site 395495001443 oligomer interface [polypeptide binding]; other site 395495001444 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 395495001445 30S subunit binding site; other site 395495001446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 395495001447 active site 395495001448 phosphorylation site [posttranslational modification] 395495001449 HPr kinase/phosphorylase; Provisional; Region: PRK05428 395495001450 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 395495001451 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 395495001452 Hpr binding site; other site 395495001453 active site 395495001454 homohexamer subunit interaction site [polypeptide binding]; other site 395495001455 ferric uptake regulator; Provisional; Region: fur; PRK09462 395495001456 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395495001457 metal binding site 2 [ion binding]; metal-binding site 395495001458 putative DNA binding helix; other site 395495001459 metal binding site 1 [ion binding]; metal-binding site 395495001460 dimer interface [polypeptide binding]; other site 395495001461 structural Zn2+ binding site [ion binding]; other site 395495001462 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 395495001463 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 395495001464 dihydrodipicolinate reductase; Provisional; Region: PRK00048 395495001465 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 395495001466 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 395495001467 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 395495001468 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495001469 TolR protein; Region: tolR; TIGR02801 395495001470 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 395495001471 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 395495001472 HIGH motif; other site 395495001473 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395495001474 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495001475 active site 395495001476 KMSKS motif; other site 395495001477 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 395495001478 tRNA binding surface [nucleotide binding]; other site 395495001479 Lipopolysaccharide-assembly; Region: LptE; cl01125 395495001480 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 395495001481 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 395495001482 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 395495001483 oligomerisation interface [polypeptide binding]; other site 395495001484 mobile loop; other site 395495001485 roof hairpin; other site 395495001486 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 395495001487 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 395495001488 ring oligomerisation interface [polypeptide binding]; other site 395495001489 ATP/Mg binding site [chemical binding]; other site 395495001490 stacking interactions; other site 395495001491 hinge regions; other site 395495001492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395495001493 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 395495001494 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 395495001495 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 395495001496 Pilin (bacterial filament); Region: Pilin; pfam00114 395495001497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495001498 Tetratricopeptide repeat; Region: TPR_12; pfam13424 395495001499 binding surface 395495001500 TPR motif; other site 395495001501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495001502 binding surface 395495001503 TPR motif; other site 395495001504 TPR repeat; Region: TPR_11; pfam13414 395495001505 TPR repeat; Region: TPR_11; pfam13414 395495001506 TPR repeat; Region: TPR_11; pfam13414 395495001507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495001508 TPR motif; other site 395495001509 binding surface 395495001510 TPR repeat; Region: TPR_11; pfam13414 395495001511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495001512 TPR motif; other site 395495001513 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495001514 O-Antigen ligase; Region: Wzy_C; pfam04932 395495001515 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 395495001516 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 395495001517 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 395495001518 Divergent AAA domain; Region: AAA_4; pfam04326 395495001519 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 395495001520 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 395495001521 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 395495001522 trimer interface [polypeptide binding]; other site 395495001523 dimer interface [polypeptide binding]; other site 395495001524 putative active site [active] 395495001525 Peptidase family M48; Region: Peptidase_M48; pfam01435 395495001526 Membrane protein of unknown function; Region: DUF360; pfam04020 395495001527 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 395495001528 CoA binding domain; Region: CoA_binding; smart00881 395495001529 CoA-ligase; Region: Ligase_CoA; pfam00549 395495001530 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 395495001531 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 395495001532 CoA-ligase; Region: Ligase_CoA; pfam00549 395495001533 recombination regulator RecX; Reviewed; Region: recX; PRK00117 395495001534 recombinase A; Provisional; Region: recA; PRK09354 395495001535 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 395495001536 hexamer interface [polypeptide binding]; other site 395495001537 Walker A motif; other site 395495001538 ATP binding site [chemical binding]; other site 395495001539 Walker B motif; other site 395495001540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495001541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495001542 active site 395495001543 phosphorylation site [posttranslational modification] 395495001544 intermolecular recognition site; other site 395495001545 dimerization interface [polypeptide binding]; other site 395495001546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495001547 DNA binding site [nucleotide binding] 395495001548 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 395495001549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495001550 HAMP domain; Region: HAMP; pfam00672 395495001551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495001552 dimer interface [polypeptide binding]; other site 395495001553 phosphorylation site [posttranslational modification] 395495001554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495001555 ATP binding site [chemical binding]; other site 395495001556 Mg2+ binding site [ion binding]; other site 395495001557 G-X-G motif; other site 395495001558 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 395495001559 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 395495001560 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 395495001561 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395495001562 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 395495001563 rod shape-determining protein MreC; Provisional; Region: PRK13922 395495001564 rod shape-determining protein MreC; Region: MreC; pfam04085 395495001565 rod shape-determining protein MreB; Provisional; Region: PRK13927 395495001566 MreB and similar proteins; Region: MreB_like; cd10225 395495001567 nucleotide binding site [chemical binding]; other site 395495001568 Mg binding site [ion binding]; other site 395495001569 putative protofilament interaction site [polypeptide binding]; other site 395495001570 RodZ interaction site [polypeptide binding]; other site 395495001571 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 395495001572 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 395495001573 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 395495001574 putative chaperone; Provisional; Region: PRK11678 395495001575 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 395495001576 nucleotide binding site [chemical binding]; other site 395495001577 putative NEF/HSP70 interaction site [polypeptide binding]; other site 395495001578 SBD interface [polypeptide binding]; other site 395495001579 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495001580 EamA-like transporter family; Region: EamA; pfam00892 395495001581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495001582 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 395495001583 putative substrate translocation pore; other site 395495001584 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 395495001585 active site 395495001586 zinc binding site [ion binding]; other site 395495001587 cell division protein MraZ; Reviewed; Region: PRK00326 395495001588 MraZ protein; Region: MraZ; pfam02381 395495001589 MraZ protein; Region: MraZ; pfam02381 395495001590 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 395495001591 MraW methylase family; Region: Methyltransf_5; cl17771 395495001592 Cell division protein FtsL; Region: FtsL; pfam04999 395495001593 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 395495001594 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 395495001595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395495001596 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 395495001597 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495001598 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495001599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395495001600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495001601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495001602 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 395495001603 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 395495001604 Mg++ binding site [ion binding]; other site 395495001605 putative catalytic motif [active] 395495001606 putative substrate binding site [chemical binding]; other site 395495001607 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 395495001608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495001609 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495001610 cell division protein FtsW; Region: ftsW; TIGR02614 395495001611 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 395495001612 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 395495001613 active site 395495001614 homodimer interface [polypeptide binding]; other site 395495001615 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 395495001616 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395495001617 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495001618 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495001619 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 395495001620 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 395495001621 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495001622 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 395495001623 Cell division protein FtsQ; Region: FtsQ; pfam03799 395495001624 cell division protein FtsA; Region: ftsA; TIGR01174 395495001625 Cell division protein FtsA; Region: FtsA; smart00842 395495001626 Cell division protein FtsA; Region: FtsA; pfam14450 395495001627 cell division protein FtsZ; Validated; Region: PRK09330 395495001628 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 395495001629 nucleotide binding site [chemical binding]; other site 395495001630 SulA interaction site; other site 395495001631 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 395495001632 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 395495001633 PAS domain; Region: PAS_9; pfam13426 395495001634 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395495001635 GAF domain; Region: GAF; pfam01590 395495001636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495001637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495001638 metal binding site [ion binding]; metal-binding site 395495001639 active site 395495001640 I-site; other site 395495001641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495001642 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 395495001643 active site 395495001644 putative DNA-binding cleft [nucleotide binding]; other site 395495001645 dimer interface [polypeptide binding]; other site 395495001646 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 395495001647 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 395495001648 purine monophosphate binding site [chemical binding]; other site 395495001649 dimer interface [polypeptide binding]; other site 395495001650 putative catalytic residues [active] 395495001651 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 395495001652 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 395495001653 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 395495001654 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 395495001655 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395495001656 FMN binding site [chemical binding]; other site 395495001657 active site 395495001658 catalytic residues [active] 395495001659 substrate binding site [chemical binding]; other site 395495001660 Predicted membrane protein [Function unknown]; Region: COG1238 395495001661 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 395495001662 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 395495001663 active site 395495001664 Zn binding site [ion binding]; other site 395495001665 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 395495001666 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 395495001667 feedback inhibition sensing region; other site 395495001668 homohexameric interface [polypeptide binding]; other site 395495001669 nucleotide binding site [chemical binding]; other site 395495001670 N-acetyl-L-glutamate binding site [chemical binding]; other site 395495001671 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395495001672 putative active site [active] 395495001673 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 395495001674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495001675 motif II; other site 395495001676 division inhibitor protein; Provisional; Region: slmA; PRK09480 395495001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495001678 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 395495001679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495001680 AAA domain; Region: AAA_14; pfam13173 395495001681 Walker A motif; other site 395495001682 ATP binding site [chemical binding]; other site 395495001683 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 395495001684 active site 395495001685 8-oxo-dGMP binding site [chemical binding]; other site 395495001686 nudix motif; other site 395495001687 metal binding site [ion binding]; metal-binding site 395495001688 Domain of unknown function (DUF329); Region: DUF329; pfam03884 395495001689 hypothetical protein; Provisional; Region: PRK05287 395495001690 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 395495001691 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 395495001692 CoA-binding site [chemical binding]; other site 395495001693 ATP-binding [chemical binding]; other site 395495001694 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 395495001695 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 395495001696 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 395495001697 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 395495001698 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495001699 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495001700 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 395495001701 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495001702 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395495001703 Walker A motif; other site 395495001704 ATP binding site [chemical binding]; other site 395495001705 Walker B motif; other site 395495001706 heat shock protein 90; Provisional; Region: PRK05218 395495001707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495001708 ATP binding site [chemical binding]; other site 395495001709 Mg2+ binding site [ion binding]; other site 395495001710 G-X-G motif; other site 395495001711 serine/threonine protein kinase; Provisional; Region: PRK11768 395495001712 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 395495001713 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 395495001714 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395495001715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495001716 Coenzyme A binding pocket [chemical binding]; other site 395495001717 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 395495001718 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395495001719 dimer interface [polypeptide binding]; other site 395495001720 ssDNA binding site [nucleotide binding]; other site 395495001721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395495001722 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 395495001723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495001724 ATP binding site [chemical binding]; other site 395495001725 putative Mg++ binding site [ion binding]; other site 395495001726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495001727 nucleotide binding region [chemical binding]; other site 395495001728 ATP-binding site [chemical binding]; other site 395495001729 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 395495001730 HRDC domain; Region: HRDC; pfam00570 395495001731 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395495001732 Patatin-like phospholipase; Region: Patatin; pfam01734 395495001733 active site 395495001734 nucleophile elbow; other site 395495001735 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 395495001736 Protein of unknown function, DUF481; Region: DUF481; cl01213 395495001737 propionate/acetate kinase; Provisional; Region: PRK12379 395495001738 Acetokinase family; Region: Acetate_kinase; cl17229 395495001739 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 395495001740 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 395495001741 ligand binding site [chemical binding]; other site 395495001742 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 395495001743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495001744 Walker A/P-loop; other site 395495001745 ATP binding site [chemical binding]; other site 395495001746 Q-loop/lid; other site 395495001747 ABC transporter signature motif; other site 395495001748 Walker B; other site 395495001749 D-loop; other site 395495001750 H-loop/switch region; other site 395495001751 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495001752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495001753 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495001754 TM-ABC transporter signature motif; other site 395495001755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495001756 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495001757 TM-ABC transporter signature motif; other site 395495001758 aldehyde dehydrogenase family 7 member; Region: PLN02315 395495001759 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 395495001760 tetrameric interface [polypeptide binding]; other site 395495001761 NAD binding site [chemical binding]; other site 395495001762 catalytic residues [active] 395495001763 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 395495001764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495001765 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395495001766 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 395495001767 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 395495001768 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 395495001769 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495001770 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 395495001771 EamA-like transporter family; Region: EamA; pfam00892 395495001772 EamA-like transporter family; Region: EamA; pfam00892 395495001773 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 395495001774 putative active site [active] 395495001775 Ap4A binding site [chemical binding]; other site 395495001776 nudix motif; other site 395495001777 putative metal binding site [ion binding]; other site 395495001778 prolyl-tRNA synthetase; Provisional; Region: PRK09194 395495001779 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 395495001780 dimer interface [polypeptide binding]; other site 395495001781 motif 1; other site 395495001782 active site 395495001783 motif 2; other site 395495001784 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 395495001785 putative deacylase active site [active] 395495001786 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 395495001787 active site 395495001788 motif 3; other site 395495001789 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 395495001790 anticodon binding site; other site 395495001791 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 395495001792 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 395495001793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495001794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495001795 catalytic residue [active] 395495001796 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 395495001797 Flavoprotein; Region: Flavoprotein; pfam02441 395495001798 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 395495001799 putative GSH binding site [chemical binding]; other site 395495001800 catalytic residues [active] 395495001801 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 395495001802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495001803 S-adenosylmethionine binding site [chemical binding]; other site 395495001804 peptide chain release factor 1; Validated; Region: prfA; PRK00591 395495001805 PCRF domain; Region: PCRF; pfam03462 395495001806 RF-1 domain; Region: RF-1; pfam00472 395495001807 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 395495001808 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 395495001809 tRNA; other site 395495001810 putative tRNA binding site [nucleotide binding]; other site 395495001811 putative NADP binding site [chemical binding]; other site 395495001812 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 395495001813 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495001814 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 395495001815 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 395495001816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495001817 FeS/SAM binding site; other site 395495001818 TRAM domain; Region: TRAM; pfam01938 395495001819 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495001820 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495001821 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 395495001822 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 395495001823 heme binding site [chemical binding]; other site 395495001824 ferroxidase pore; other site 395495001825 ferroxidase diiron center [ion binding]; other site 395495001826 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 395495001827 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 395495001828 tandem repeat interface [polypeptide binding]; other site 395495001829 oligomer interface [polypeptide binding]; other site 395495001830 active site residues [active] 395495001831 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 395495001832 iron-sulfur cluster [ion binding]; other site 395495001833 [2Fe-2S] cluster binding site [ion binding]; other site 395495001834 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 395495001835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495001836 motif II; other site 395495001837 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 395495001838 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 395495001839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495001840 RNA binding surface [nucleotide binding]; other site 395495001841 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 395495001842 active site 395495001843 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 395495001844 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 395495001845 homodimer interface [polypeptide binding]; other site 395495001846 oligonucleotide binding site [chemical binding]; other site 395495001847 beta-hexosaminidase; Provisional; Region: PRK05337 395495001848 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 395495001849 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 395495001850 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 395495001851 active site 395495001852 hydrophilic channel; other site 395495001853 dimerization interface [polypeptide binding]; other site 395495001854 catalytic residues [active] 395495001855 active site lid [active] 395495001856 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 395495001857 Recombination protein O N terminal; Region: RecO_N; pfam11967 395495001858 Recombination protein O C terminal; Region: RecO_C; pfam02565 395495001859 GTPase Era; Reviewed; Region: era; PRK00089 395495001860 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 395495001861 G1 box; other site 395495001862 GTP/Mg2+ binding site [chemical binding]; other site 395495001863 Switch I region; other site 395495001864 G2 box; other site 395495001865 Switch II region; other site 395495001866 G3 box; other site 395495001867 G4 box; other site 395495001868 G5 box; other site 395495001869 KH domain; Region: KH_2; pfam07650 395495001870 ribonuclease III; Reviewed; Region: rnc; PRK00102 395495001871 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 395495001872 dimerization interface [polypeptide binding]; other site 395495001873 active site 395495001874 metal binding site [ion binding]; metal-binding site 395495001875 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 395495001876 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 395495001877 signal peptidase I; Provisional; Region: PRK10861 395495001878 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395495001879 Catalytic site [active] 395495001880 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 395495001881 GTP-binding protein LepA; Provisional; Region: PRK05433 395495001882 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 395495001883 G1 box; other site 395495001884 putative GEF interaction site [polypeptide binding]; other site 395495001885 GTP/Mg2+ binding site [chemical binding]; other site 395495001886 Switch I region; other site 395495001887 G2 box; other site 395495001888 G3 box; other site 395495001889 Switch II region; other site 395495001890 G4 box; other site 395495001891 G5 box; other site 395495001892 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 395495001893 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 395495001894 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 395495001895 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 395495001896 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495001897 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495001898 protein binding site [polypeptide binding]; other site 395495001899 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495001900 protein binding site [polypeptide binding]; other site 395495001901 MucB/RseB family; Region: MucB_RseB; pfam03888 395495001902 anti-sigma E factor; Provisional; Region: rseB; PRK09455 395495001903 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 395495001904 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 395495001905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495001906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495001907 DNA binding residues [nucleotide binding] 395495001908 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 395495001909 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 395495001910 dimer interface [polypeptide binding]; other site 395495001911 active site 395495001912 acyl carrier protein; Provisional; Region: acpP; PRK00982 395495001913 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 395495001914 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 395495001915 NAD(P) binding site [chemical binding]; other site 395495001916 homotetramer interface [polypeptide binding]; other site 395495001917 homodimer interface [polypeptide binding]; other site 395495001918 active site 395495001919 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 395495001920 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 395495001921 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 395495001922 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 395495001923 dimer interface [polypeptide binding]; other site 395495001924 active site 395495001925 CoA binding pocket [chemical binding]; other site 395495001926 putative phosphate acyltransferase; Provisional; Region: PRK05331 395495001927 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 395495001928 Maf-like protein; Region: Maf; pfam02545 395495001929 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 395495001930 active site 395495001931 dimer interface [polypeptide binding]; other site 395495001932 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 395495001933 putative SAM binding site [chemical binding]; other site 395495001934 homodimer interface [polypeptide binding]; other site 395495001935 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395495001936 DEAD-like helicases superfamily; Region: DEXDc; smart00487 395495001937 ATP binding site [chemical binding]; other site 395495001938 Mg++ binding site [ion binding]; other site 395495001939 motif III; other site 395495001940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495001941 nucleotide binding region [chemical binding]; other site 395495001942 ATP-binding site [chemical binding]; other site 395495001943 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 395495001944 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 395495001945 Mg++ binding site [ion binding]; other site 395495001946 putative catalytic motif [active] 395495001947 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 395495001948 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 395495001949 NAD binding site [chemical binding]; other site 395495001950 substrate binding site [chemical binding]; other site 395495001951 homodimer interface [polypeptide binding]; other site 395495001952 active site 395495001953 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 395495001954 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 395495001955 NADP binding site [chemical binding]; other site 395495001956 active site 395495001957 putative substrate binding site [chemical binding]; other site 395495001958 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 395495001959 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 395495001960 substrate binding site; other site 395495001961 tetramer interface; other site 395495001962 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 395495001963 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 395495001964 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 395495001965 Substrate binding site; other site 395495001966 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 395495001967 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 395495001968 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 395495001969 NADP binding site [chemical binding]; other site 395495001970 active site 395495001971 putative substrate binding site [chemical binding]; other site 395495001972 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 395495001973 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 395495001974 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395495001975 NADP-binding site; other site 395495001976 homotetramer interface [polypeptide binding]; other site 395495001977 substrate binding site [chemical binding]; other site 395495001978 homodimer interface [polypeptide binding]; other site 395495001979 active site 395495001980 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395495001981 putative active site [active] 395495001982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495001983 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 395495001984 putative ADP-binding pocket [chemical binding]; other site 395495001985 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395495001986 putative active site [active] 395495001987 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 395495001988 Calx-beta domain; Region: Calx-beta; cl02522 395495001989 Calx-beta domain; Region: Calx-beta; cl02522 395495001990 Calx-beta domain; Region: Calx-beta; cl02522 395495001991 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 395495001992 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 395495001993 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 395495001994 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 395495001995 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 395495001996 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 395495001997 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395495001998 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495001999 inhibitor-cofactor binding pocket; inhibition site 395495002000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002001 catalytic residue [active] 395495002002 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 395495002003 trimer interface [polypeptide binding]; other site 395495002004 active site 395495002005 substrate binding site [chemical binding]; other site 395495002006 CoA binding site [chemical binding]; other site 395495002007 4-alpha-L-fucosyltransferase; Provisional; Region: PRK02797 395495002008 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 395495002009 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 395495002010 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 395495002011 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 395495002012 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 395495002013 homodimer interface [polypeptide binding]; other site 395495002014 active site 395495002015 Chain length determinant protein; Region: Wzz; cl15801 395495002016 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 395495002017 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 395495002018 Protein of unknown function DUF86; Region: DUF86; cl01031 395495002019 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 395495002020 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 395495002021 SLBB domain; Region: SLBB; pfam10531 395495002022 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 395495002023 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395495002024 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395495002025 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495002026 Cu(I) binding site [ion binding]; other site 395495002027 Cytochrome c; Region: Cytochrom_C; pfam00034 395495002028 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 395495002029 chorismate binding enzyme; Region: Chorismate_bind; cl10555 395495002030 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 395495002031 Aminotransferase class IV; Region: Aminotran_4; pfam01063 395495002032 substrate-cofactor binding pocket; other site 395495002033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002034 catalytic residue [active] 395495002035 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 395495002036 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 395495002037 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 395495002038 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 395495002039 G1 box; other site 395495002040 GTP/Mg2+ binding site [chemical binding]; other site 395495002041 G2 box; other site 395495002042 Switch I region; other site 395495002043 G3 box; other site 395495002044 Switch II region; other site 395495002045 G4 box; other site 395495002046 G5 box; other site 395495002047 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 395495002048 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 395495002049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495002050 PAS fold; Region: PAS_3; pfam08447 395495002051 putative active site [active] 395495002052 heme pocket [chemical binding]; other site 395495002053 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 395495002054 FimV N-terminal domain; Region: FimV_core; TIGR03505 395495002055 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 395495002056 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 395495002057 cysteine synthase B; Region: cysM; TIGR01138 395495002058 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395495002059 dimer interface [polypeptide binding]; other site 395495002060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002061 catalytic residue [active] 395495002062 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 395495002063 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395495002064 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495002065 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 395495002066 protein binding site [polypeptide binding]; other site 395495002067 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 395495002068 putative NAD(P) binding site [chemical binding]; other site 395495002069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495002070 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 395495002071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495002072 catalytic loop [active] 395495002073 iron binding site [ion binding]; other site 395495002074 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 395495002075 FAD binding pocket [chemical binding]; other site 395495002076 FAD binding motif [chemical binding]; other site 395495002077 phosphate binding motif [ion binding]; other site 395495002078 beta-alpha-beta structure motif; other site 395495002079 NAD binding pocket [chemical binding]; other site 395495002080 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 395495002081 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 395495002082 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 395495002083 Uncharacterized conserved protein [Function unknown]; Region: COG2912 395495002084 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 395495002085 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 395495002086 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 395495002087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 395495002088 Walker A motif; other site 395495002089 ATP binding site [chemical binding]; other site 395495002090 Walker B motif; other site 395495002091 arginine finger; other site 395495002092 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395495002093 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395495002094 poly(A) polymerase; Region: pcnB; TIGR01942 395495002095 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 395495002096 active site 395495002097 NTP binding site [chemical binding]; other site 395495002098 metal binding triad [ion binding]; metal-binding site 395495002099 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 395495002100 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 395495002101 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 395495002102 catalytic center binding site [active] 395495002103 ATP binding site [chemical binding]; other site 395495002104 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 395495002105 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 395495002106 TM2 domain; Region: TM2; pfam05154 395495002107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 395495002108 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 395495002109 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 395495002110 RimM N-terminal domain; Region: RimM; pfam01782 395495002111 PRC-barrel domain; Region: PRC; pfam05239 395495002112 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 395495002113 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 395495002114 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 395495002115 putative active site [active] 395495002116 putative CoA binding site [chemical binding]; other site 395495002117 nudix motif; other site 395495002118 metal binding site [ion binding]; metal-binding site 395495002119 CobD/Cbib protein; Region: CobD_Cbib; cl00561 395495002120 Protein of unknown function, DUF599; Region: DUF599; pfam04654 395495002121 Pirin-related protein [General function prediction only]; Region: COG1741 395495002122 Pirin; Region: Pirin; pfam02678 395495002123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002124 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 395495002125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495002126 dimerization interface [polypeptide binding]; other site 395495002127 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 395495002128 active site 395495002129 HIGH motif; other site 395495002130 nucleotide binding site [chemical binding]; other site 395495002131 active site 395495002132 KMSKS motif; other site 395495002133 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 395495002134 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 395495002135 seryl-tRNA synthetase; Provisional; Region: PRK05431 395495002136 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 395495002137 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 395495002138 dimer interface [polypeptide binding]; other site 395495002139 active site 395495002140 motif 1; other site 395495002141 motif 2; other site 395495002142 motif 3; other site 395495002143 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 395495002144 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 395495002145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 395495002146 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 395495002147 hypothetical protein; Reviewed; Region: PRK00024 395495002148 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 395495002149 MPN+ (JAMM) motif; other site 395495002150 Zinc-binding site [ion binding]; other site 395495002151 Smr domain; Region: Smr; pfam01713 395495002152 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 395495002153 apolar tunnel; other site 395495002154 heme binding site [chemical binding]; other site 395495002155 dimerization interface [polypeptide binding]; other site 395495002156 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 395495002157 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 395495002158 P-loop; other site 395495002159 ADP binding residues [chemical binding]; other site 395495002160 Switch I; other site 395495002161 Switch II; other site 395495002162 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495002163 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495002164 metal binding site [ion binding]; metal-binding site 395495002165 active site 395495002166 I-site; other site 395495002167 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 395495002168 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 395495002169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495002170 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 395495002171 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 395495002172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002173 active site 395495002174 phosphorylation site [posttranslational modification] 395495002175 intermolecular recognition site; other site 395495002176 dimerization interface [polypeptide binding]; other site 395495002177 CheB methylesterase; Region: CheB_methylest; pfam01339 395495002178 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 395495002179 HemN C-terminal domain; Region: HemN_C; pfam06969 395495002180 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 395495002181 active site 395495002182 dimerization interface [polypeptide binding]; other site 395495002183 ribonuclease PH; Reviewed; Region: rph; PRK00173 395495002184 Ribonuclease PH; Region: RNase_PH_bact; cd11362 395495002185 hexamer interface [polypeptide binding]; other site 395495002186 active site 395495002187 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395495002188 Protein phosphatase 2C; Region: PP2C; pfam00481 395495002189 active site 395495002190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495002191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395495002192 active site 395495002193 ATP binding site [chemical binding]; other site 395495002194 substrate binding site [chemical binding]; other site 395495002195 activation loop (A-loop); other site 395495002196 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495002197 hypothetical protein; Provisional; Region: PRK11820 395495002198 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 395495002199 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 395495002200 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 395495002201 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 395495002202 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495002203 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395495002204 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495002205 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495002206 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495002207 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495002208 trimer interface [polypeptide binding]; other site 395495002209 eyelet of channel; other site 395495002210 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 395495002211 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495002212 Putative cyclase; Region: Cyclase; cl00814 395495002213 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 395495002214 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 395495002215 ligand binding site [chemical binding]; other site 395495002216 NAD binding site [chemical binding]; other site 395495002217 dimerization interface [polypeptide binding]; other site 395495002218 catalytic site [active] 395495002219 hypothetical protein; Validated; Region: PRK06201 395495002220 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 395495002221 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495002222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495002223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002224 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 395495002225 putative dimerization interface [polypeptide binding]; other site 395495002226 Uncharacterized conserved protein [Function unknown]; Region: COG4925 395495002227 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 395495002228 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 395495002229 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 395495002230 TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity; Region: TFIIE_beta_winged_helix; cl02153 395495002231 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 395495002232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495002233 DNA-binding site [nucleotide binding]; DNA binding site 395495002234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495002235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002236 homodimer interface [polypeptide binding]; other site 395495002237 catalytic residue [active] 395495002238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495002239 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 395495002240 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 395495002241 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 395495002242 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 395495002243 catalytic site [active] 395495002244 G-X2-G-X-G-K; other site 395495002245 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 395495002246 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 395495002247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495002248 Zn2+ binding site [ion binding]; other site 395495002249 Mg2+ binding site [ion binding]; other site 395495002250 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 395495002251 synthetase active site [active] 395495002252 NTP binding site [chemical binding]; other site 395495002253 metal binding site [ion binding]; metal-binding site 395495002254 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 395495002255 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 395495002256 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 395495002257 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 395495002258 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 395495002259 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 395495002260 DNA binding residues [nucleotide binding] 395495002261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002262 phosphorylation site [posttranslational modification] 395495002263 intermolecular recognition site; other site 395495002264 Response regulator receiver domain; Region: Response_reg; pfam00072 395495002265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002266 active site 395495002267 phosphorylation site [posttranslational modification] 395495002268 intermolecular recognition site; other site 395495002269 dimerization interface [polypeptide binding]; other site 395495002270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495002271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002272 active site 395495002273 phosphorylation site [posttranslational modification] 395495002274 intermolecular recognition site; other site 395495002275 dimerization interface [polypeptide binding]; other site 395495002276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495002277 DNA binding site [nucleotide binding] 395495002278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495002279 dimerization interface [polypeptide binding]; other site 395495002280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495002281 dimer interface [polypeptide binding]; other site 395495002282 phosphorylation site [posttranslational modification] 395495002283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495002284 ATP binding site [chemical binding]; other site 395495002285 Mg2+ binding site [ion binding]; other site 395495002286 G-X-G motif; other site 395495002287 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 395495002288 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 395495002289 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 395495002290 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 395495002291 active site 395495002292 HIGH motif; other site 395495002293 dimer interface [polypeptide binding]; other site 395495002294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495002295 active site 395495002296 KMSKS motif; other site 395495002297 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 395495002298 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 395495002299 active site 395495002300 substrate binding site [chemical binding]; other site 395495002301 cosubstrate binding site; other site 395495002302 catalytic site [active] 395495002303 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 395495002304 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 395495002305 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 395495002306 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395495002307 Di-iron ligands [ion binding]; other site 395495002308 Transposase; Region: DDE_Tnp_ISL3; pfam01610 395495002309 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 395495002310 Peptidase family M23; Region: Peptidase_M23; pfam01551 395495002311 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 395495002312 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 395495002313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 395495002314 nucleotide binding region [chemical binding]; other site 395495002315 ATP-binding site [chemical binding]; other site 395495002316 SEC-C motif; Region: SEC-C; pfam02810 395495002317 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 395495002318 heterotetramer interface [polypeptide binding]; other site 395495002319 active site pocket [active] 395495002320 cleavage site 395495002321 Calx-beta domain; Region: Calx-beta; cl02522 395495002322 Calx-beta domain; Region: Calx-beta; cl02522 395495002323 Calx-beta domain; Region: Calx-beta; cl02522 395495002324 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 395495002325 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 395495002326 metal ion-dependent adhesion site (MIDAS); other site 395495002327 VCBS repeat; Region: VCBS_repeat; TIGR01965 395495002328 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495002329 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495002330 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 395495002331 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 395495002332 active site 395495002333 catalytic site [active] 395495002334 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 395495002335 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395495002336 FAD binding domain; Region: FAD_binding_4; pfam01565 395495002337 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395495002338 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 395495002339 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 395495002340 Cysteine-rich domain; Region: CCG; pfam02754 395495002341 Cysteine-rich domain; Region: CCG; pfam02754 395495002342 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 395495002343 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 395495002344 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 395495002345 thioredoxin reductase; Provisional; Region: PRK10262 395495002346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495002347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495002348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495002349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495002350 ligand binding site [chemical binding]; other site 395495002351 flexible hinge region; other site 395495002352 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495002353 putative switch regulator; other site 395495002354 non-specific DNA interactions [nucleotide binding]; other site 395495002355 DNA binding site [nucleotide binding] 395495002356 sequence specific DNA binding site [nucleotide binding]; other site 395495002357 putative cAMP binding site [chemical binding]; other site 395495002358 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 395495002359 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 395495002360 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 395495002361 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 395495002362 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 395495002363 recombination factor protein RarA; Reviewed; Region: PRK13342 395495002364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495002365 Walker A motif; other site 395495002366 ATP binding site [chemical binding]; other site 395495002367 Walker B motif; other site 395495002368 arginine finger; other site 395495002369 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 395495002370 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495002371 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495002372 TM-ABC transporter signature motif; other site 395495002373 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495002374 TM-ABC transporter signature motif; other site 395495002375 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495002376 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495002377 Walker A/P-loop; other site 395495002378 ATP binding site [chemical binding]; other site 395495002379 Q-loop/lid; other site 395495002380 ABC transporter signature motif; other site 395495002381 Walker B; other site 395495002382 D-loop; other site 395495002383 H-loop/switch region; other site 395495002384 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495002385 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495002386 Walker A/P-loop; other site 395495002387 ATP binding site [chemical binding]; other site 395495002388 Q-loop/lid; other site 395495002389 ABC transporter signature motif; other site 395495002390 Walker B; other site 395495002391 D-loop; other site 395495002392 H-loop/switch region; other site 395495002393 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 395495002394 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 395495002395 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 395495002396 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 395495002397 domain interfaces; other site 395495002398 active site 395495002399 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 395495002400 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 395495002401 active site 395495002402 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 395495002403 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 395495002404 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 395495002405 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 395495002406 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 395495002407 Int/Topo IB signature motif; other site 395495002408 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495002409 active site 395495002410 DNA binding site [nucleotide binding] 395495002411 Int/Topo IB signature motif; other site 395495002412 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 395495002413 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 395495002414 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495002415 active site 395495002416 DNA binding site [nucleotide binding] 395495002417 Int/Topo IB signature motif; other site 395495002418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495002419 ATP binding site [chemical binding]; other site 395495002420 putative Mg++ binding site [ion binding]; other site 395495002421 helicase superfamily c-terminal domain; Region: HELICc; smart00490 395495002422 DDE superfamily endonuclease; Region: DDE_3; pfam13358 395495002423 Homeodomain-like domain; Region: HTH_23; pfam13384 395495002424 Winged helix-turn helix; Region: HTH_29; pfam13551 395495002425 Homeodomain-like domain; Region: HTH_32; pfam13565 395495002426 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 395495002427 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 395495002428 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 395495002429 Int/Topo IB signature motif; other site 395495002430 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495002431 active site 395495002432 DNA binding site [nucleotide binding] 395495002433 Int/Topo IB signature motif; other site 395495002434 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 395495002435 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495002436 active site 395495002437 DNA binding site [nucleotide binding] 395495002438 Int/Topo IB signature motif; other site 395495002439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495002440 Transposase; Region: HTH_Tnp_1; pfam01527 395495002441 putative transposase OrfB; Reviewed; Region: PHA02517 395495002442 Integrase core domain; Region: rve; pfam00665 395495002443 Integrase core domain; Region: rve_3; pfam13683 395495002444 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 395495002445 ssDNA binding site [nucleotide binding]; other site 395495002446 dimer interface [polypeptide binding]; other site 395495002447 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395495002448 Domain of unknown function (DUF932); Region: DUF932; pfam06067 395495002449 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395495002450 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495002451 P-loop; other site 395495002452 Magnesium ion binding site [ion binding]; other site 395495002453 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495002454 Magnesium ion binding site [ion binding]; other site 395495002455 ParB-like nuclease domain; Region: ParB; smart00470 395495002456 KorB domain; Region: KorB; pfam08535 395495002457 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 395495002458 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 395495002459 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 395495002460 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 395495002461 putative hydrolase; Provisional; Region: PRK11460 395495002462 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 395495002463 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495002464 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495002465 Walker A/P-loop; other site 395495002466 ATP binding site [chemical binding]; other site 395495002467 Q-loop/lid; other site 395495002468 ABC transporter signature motif; other site 395495002469 Walker B; other site 395495002470 D-loop; other site 395495002471 H-loop/switch region; other site 395495002472 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495002473 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495002474 Walker A/P-loop; other site 395495002475 ATP binding site [chemical binding]; other site 395495002476 Q-loop/lid; other site 395495002477 ABC transporter signature motif; other site 395495002478 Walker B; other site 395495002479 D-loop; other site 395495002480 H-loop/switch region; other site 395495002481 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495002482 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495002483 TM-ABC transporter signature motif; other site 395495002484 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495002485 TM-ABC transporter signature motif; other site 395495002486 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495002487 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 395495002488 putative ligand binding site [chemical binding]; other site 395495002489 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 395495002490 [2Fe-2S] cluster binding site [ion binding]; other site 395495002491 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 395495002492 inter-subunit interface; other site 395495002493 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395495002494 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395495002495 iron-sulfur cluster [ion binding]; other site 395495002496 [2Fe-2S] cluster binding site [ion binding]; other site 395495002497 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 395495002498 putative alpha subunit interface [polypeptide binding]; other site 395495002499 putative active site [active] 395495002500 putative substrate binding site [chemical binding]; other site 395495002501 Fe binding site [ion binding]; other site 395495002502 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395495002503 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495002504 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 395495002505 Cupin domain; Region: Cupin_2; pfam07883 395495002506 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 395495002507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495002508 catalytic loop [active] 395495002509 iron binding site [ion binding]; other site 395495002510 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 395495002511 FAD binding pocket [chemical binding]; other site 395495002512 FAD binding motif [chemical binding]; other site 395495002513 phosphate binding motif [ion binding]; other site 395495002514 beta-alpha-beta structure motif; other site 395495002515 NAD binding pocket [chemical binding]; other site 395495002516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495002517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002518 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 395495002519 substrate binding pocket [chemical binding]; other site 395495002520 dimerization interface [polypeptide binding]; other site 395495002521 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495002522 choline dehydrogenase; Validated; Region: PRK02106 395495002523 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395495002524 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495002525 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 395495002526 NAD(P) binding site [chemical binding]; other site 395495002527 catalytic residues [active] 395495002528 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495002529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495002530 DNA binding site [nucleotide binding] 395495002531 domain linker motif; other site 395495002532 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495002534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495002535 putative substrate translocation pore; other site 395495002536 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 395495002537 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 395495002538 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 395495002539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395495002540 N-terminal plug; other site 395495002541 ligand-binding site [chemical binding]; other site 395495002542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395495002543 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395495002544 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495002545 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495002546 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495002547 TolR protein; Region: tolR; TIGR02801 395495002548 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 395495002549 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 395495002550 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395495002551 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 395495002552 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495002553 classical (c) SDRs; Region: SDR_c; cd05233 395495002554 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 395495002555 NAD(P) binding site [chemical binding]; other site 395495002556 active site 395495002557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495002558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495002559 Uncharacterized conserved protein [Function unknown]; Region: COG3777 395495002560 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395495002561 active site 2 [active] 395495002562 active site 1 [active] 395495002563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495002564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 395495002565 active site 395495002566 metal binding site [ion binding]; metal-binding site 395495002567 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495002568 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495002569 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 395495002570 DctM-like transporters; Region: DctM; pfam06808 395495002571 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495002572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495002573 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495002574 NAD(P) binding site [chemical binding]; other site 395495002575 active site 395495002576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495002577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495002578 NAD(P) binding site [chemical binding]; other site 395495002579 active site 395495002580 Cupin domain; Region: Cupin_2; pfam07883 395495002581 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 395495002582 Hemerythrin-like domain; Region: Hr-like; cd12108 395495002583 Fe binding site [ion binding]; other site 395495002584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495002585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002586 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 395495002587 putative effector binding pocket; other site 395495002588 putative dimerization interface [polypeptide binding]; other site 395495002589 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 395495002590 active site 1 [active] 395495002591 dimer interface [polypeptide binding]; other site 395495002592 hexamer interface [polypeptide binding]; other site 395495002593 active site 2 [active] 395495002594 Uncharacterized conserved protein [Function unknown]; Region: COG3791 395495002595 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 395495002596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495002597 dimer interface [polypeptide binding]; other site 395495002598 active site 395495002599 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 395495002600 Coenzyme A transferase; Region: CoA_trans; cl17247 395495002601 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 395495002602 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 395495002603 dimer interface [polypeptide binding]; other site 395495002604 active site 395495002605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002606 LysR family transcriptional regulator; Provisional; Region: PRK14997 395495002607 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495002608 putative effector binding pocket; other site 395495002609 dimerization interface [polypeptide binding]; other site 395495002610 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 395495002611 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 395495002612 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 395495002613 active site 395495002614 dimer interface [polypeptide binding]; other site 395495002615 metal binding site [ion binding]; metal-binding site 395495002616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495002617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495002618 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 395495002619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495002620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495002621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495002622 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 395495002623 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 395495002624 putative ligand binding site [chemical binding]; other site 395495002625 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395495002626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495002627 Walker A/P-loop; other site 395495002628 ATP binding site [chemical binding]; other site 395495002629 Q-loop/lid; other site 395495002630 ABC transporter signature motif; other site 395495002631 Walker B; other site 395495002632 D-loop; other site 395495002633 H-loop/switch region; other site 395495002634 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495002635 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495002636 TM-ABC transporter signature motif; other site 395495002637 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 395495002638 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495002639 dimer interface [polypeptide binding]; other site 395495002640 active site 395495002641 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 395495002642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495002643 substrate binding site [chemical binding]; other site 395495002644 oxyanion hole (OAH) forming residues; other site 395495002645 trimer interface [polypeptide binding]; other site 395495002646 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395495002647 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495002648 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495002649 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495002650 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495002651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495002652 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495002653 active site 395495002654 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495002655 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 395495002656 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 395495002657 Trp docking motif [polypeptide binding]; other site 395495002658 active site 395495002659 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495002660 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 395495002661 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 395495002662 Trp docking motif [polypeptide binding]; other site 395495002663 active site 395495002664 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395495002665 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 395495002666 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 395495002667 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 395495002668 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 395495002669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495002670 Walker A motif; other site 395495002671 ATP binding site [chemical binding]; other site 395495002672 Walker B motif; other site 395495002673 arginine finger; other site 395495002674 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495002675 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 395495002676 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 395495002677 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395495002678 dimerization interface [polypeptide binding]; other site 395495002679 active site 395495002680 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495002681 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 395495002682 tetramerization interface [polypeptide binding]; other site 395495002683 NAD(P) binding site [chemical binding]; other site 395495002684 catalytic residues [active] 395495002685 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495002686 Ligand binding site [chemical binding]; other site 395495002687 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495002688 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495002689 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495002690 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495002691 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 395495002692 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495002693 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495002694 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495002695 ligand binding site [chemical binding]; other site 395495002696 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 395495002697 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495002698 Walker A motif; other site 395495002699 ATP binding site [chemical binding]; other site 395495002700 Walker B motif; other site 395495002701 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 395495002702 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 395495002703 Walker A motif; other site 395495002704 hexamer interface [polypeptide binding]; other site 395495002705 ATP binding site [chemical binding]; other site 395495002706 Walker B motif; other site 395495002707 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 395495002708 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 395495002709 VirB7 interaction site; other site 395495002710 VirB8 protein; Region: VirB8; pfam04335 395495002711 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 395495002712 Type IV secretion system proteins; Region: T4SS; pfam07996 395495002713 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 395495002714 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 395495002715 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 395495002716 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 395495002717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495002718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495002719 catalytic residue [active] 395495002720 Autoinducer binding domain; Region: Autoind_bind; pfam03472 395495002721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495002722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495002723 DNA binding residues [nucleotide binding] 395495002724 dimerization interface [polypeptide binding]; other site 395495002725 ACT domain; Region: ACT_3; pfam10000 395495002726 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 395495002727 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395495002728 putative di-iron ligands [ion binding]; other site 395495002729 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 395495002730 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 395495002731 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 395495002732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495002734 dimerization interface [polypeptide binding]; other site 395495002735 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 395495002736 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 395495002737 Helix-turn-helix domain; Region: HTH_38; pfam13936 395495002738 Integrase core domain; Region: rve; pfam00665 395495002739 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 395495002740 putative N- and C-terminal domain interface [polypeptide binding]; other site 395495002741 putative active site [active] 395495002742 putative MgATP binding site [chemical binding]; other site 395495002743 catalytic site [active] 395495002744 metal binding site [ion binding]; metal-binding site 395495002745 putative carbohydrate binding site [chemical binding]; other site 395495002746 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 395495002747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 395495002748 NAD(P) binding site [chemical binding]; other site 395495002749 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 395495002750 Class I aldolases; Region: Aldolase_Class_I; cl17187 395495002751 catalytic residue [active] 395495002752 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 395495002753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495002754 DNA-binding site [nucleotide binding]; DNA binding site 395495002755 UTRA domain; Region: UTRA; pfam07702 395495002756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495002757 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395495002758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495002759 dimer interface [polypeptide binding]; other site 395495002760 conserved gate region; other site 395495002761 putative PBP binding loops; other site 395495002762 ABC-ATPase subunit interface; other site 395495002763 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495002764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495002765 dimer interface [polypeptide binding]; other site 395495002766 conserved gate region; other site 395495002767 putative PBP binding loops; other site 395495002768 ABC-ATPase subunit interface; other site 395495002769 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395495002770 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495002771 Walker A/P-loop; other site 395495002772 ATP binding site [chemical binding]; other site 395495002773 Q-loop/lid; other site 395495002774 ABC transporter signature motif; other site 395495002775 Walker B; other site 395495002776 D-loop; other site 395495002777 H-loop/switch region; other site 395495002778 TOBE domain; Region: TOBE_2; pfam08402 395495002779 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 395495002780 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 395495002781 DAK2 domain; Region: Dak2; pfam02734 395495002782 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 395495002783 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 395495002784 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 395495002785 Helix-turn-helix domain; Region: HTH_18; pfam12833 395495002786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495002787 Fic family protein [Function unknown]; Region: COG3177 395495002788 Fic/DOC family; Region: Fic; pfam02661 395495002789 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495002790 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 395495002791 DNA binding site [nucleotide binding] 395495002792 Int/Topo IB signature motif; other site 395495002793 active site 395495002794 catalytic residues [active] 395495002795 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395495002796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495002797 active site 395495002798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495002799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002800 active site 395495002801 phosphorylation site [posttranslational modification] 395495002802 intermolecular recognition site; other site 395495002803 dimerization interface [polypeptide binding]; other site 395495002804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495002805 DNA binding residues [nucleotide binding] 395495002806 dimerization interface [polypeptide binding]; other site 395495002807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495002808 PAS domain; Region: PAS_9; pfam13426 395495002809 putative active site [active] 395495002810 heme pocket [chemical binding]; other site 395495002811 PAS domain S-box; Region: sensory_box; TIGR00229 395495002812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495002813 putative active site [active] 395495002814 heme pocket [chemical binding]; other site 395495002815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395495002816 Histidine kinase; Region: HisKA_3; pfam07730 395495002817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495002818 ATP binding site [chemical binding]; other site 395495002819 Mg2+ binding site [ion binding]; other site 395495002820 G-X-G motif; other site 395495002821 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495002822 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495002823 ligand binding site [chemical binding]; other site 395495002824 flexible hinge region; other site 395495002825 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495002826 putative switch regulator; other site 395495002827 non-specific DNA interactions [nucleotide binding]; other site 395495002828 DNA binding site [nucleotide binding] 395495002829 sequence specific DNA binding site [nucleotide binding]; other site 395495002830 putative cAMP binding site [chemical binding]; other site 395495002831 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 395495002832 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 395495002833 acetylornithine aminotransferase; Provisional; Region: PRK02627 395495002834 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495002835 inhibitor-cofactor binding pocket; inhibition site 395495002836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002837 catalytic residue [active] 395495002838 ornithine carbamoyltransferase; Provisional; Region: PRK00779 395495002839 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395495002840 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 395495002841 MltA-interacting protein MipA; Region: MipA; cl01504 395495002842 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 395495002843 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395495002844 active site 395495002845 metal binding site [ion binding]; metal-binding site 395495002846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495002847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395495002848 active site 395495002849 ATP binding site [chemical binding]; other site 395495002850 substrate binding site [chemical binding]; other site 395495002851 activation loop (A-loop); other site 395495002852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495002853 Ligand Binding Site [chemical binding]; other site 395495002854 argininosuccinate synthase; Validated; Region: PRK05370 395495002855 argininosuccinate synthase; Provisional; Region: PRK13820 395495002856 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 395495002857 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 395495002858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495002859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495002860 dimer interface [polypeptide binding]; other site 395495002861 phosphorylation site [posttranslational modification] 395495002862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495002863 ATP binding site [chemical binding]; other site 395495002864 Mg2+ binding site [ion binding]; other site 395495002865 G-X-G motif; other site 395495002866 Response regulator receiver domain; Region: Response_reg; pfam00072 395495002867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002868 active site 395495002869 phosphorylation site [posttranslational modification] 395495002870 intermolecular recognition site; other site 395495002871 dimerization interface [polypeptide binding]; other site 395495002872 DNA repair protein RadA; Provisional; Region: PRK11823 395495002873 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 395495002874 Walker A motif/ATP binding site; other site 395495002875 ATP binding site [chemical binding]; other site 395495002876 Walker B motif; other site 395495002877 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 395495002878 LysE type translocator; Region: LysE; cl00565 395495002879 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 395495002880 hypothetical protein; Provisional; Region: PRK09256 395495002881 alanine racemase; Reviewed; Region: dadX; PRK03646 395495002882 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 395495002883 active site 395495002884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395495002885 substrate binding site [chemical binding]; other site 395495002886 catalytic residues [active] 395495002887 dimer interface [polypeptide binding]; other site 395495002888 lysophospholipid transporter LplT; Provisional; Region: PRK11195 395495002889 Response regulator receiver domain; Region: Response_reg; pfam00072 395495002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495002891 active site 395495002892 phosphorylation site [posttranslational modification] 395495002893 intermolecular recognition site; other site 395495002894 dimerization interface [polypeptide binding]; other site 395495002895 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 395495002896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495002898 homodimer interface [polypeptide binding]; other site 395495002899 catalytic residue [active] 395495002900 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 395495002901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002902 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 395495002903 substrate binding pocket [chemical binding]; other site 395495002904 dimerization interface [polypeptide binding]; other site 395495002905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495002906 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 395495002907 NAD(P) binding site [chemical binding]; other site 395495002908 catalytic residues [active] 395495002909 catalytic residues [active] 395495002910 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 395495002911 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 395495002912 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 395495002913 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 395495002914 [2Fe-2S] cluster binding site [ion binding]; other site 395495002915 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 395495002916 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 395495002917 Qi binding site; other site 395495002918 intrachain domain interface; other site 395495002919 interchain domain interface [polypeptide binding]; other site 395495002920 heme bH binding site [chemical binding]; other site 395495002921 heme bL binding site [chemical binding]; other site 395495002922 Qo binding site; other site 395495002923 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 395495002924 interchain domain interface [polypeptide binding]; other site 395495002925 intrachain domain interface; other site 395495002926 Qi binding site; other site 395495002927 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 395495002928 Qo binding site; other site 395495002929 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 395495002930 stringent starvation protein A; Provisional; Region: sspA; PRK09481 395495002931 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 395495002932 C-terminal domain interface [polypeptide binding]; other site 395495002933 putative GSH binding site (G-site) [chemical binding]; other site 395495002934 dimer interface [polypeptide binding]; other site 395495002935 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 395495002936 dimer interface [polypeptide binding]; other site 395495002937 N-terminal domain interface [polypeptide binding]; other site 395495002938 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 395495002939 Class I aldolases; Region: Aldolase_Class_I; cl17187 395495002940 catalytic residue [active] 395495002941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 395495002942 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 395495002943 active site 395495002944 DNA polymerase IV; Validated; Region: PRK02406 395495002945 DNA binding site [nucleotide binding] 395495002946 protease TldD; Provisional; Region: tldD; PRK10735 395495002947 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 395495002948 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 395495002949 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 395495002950 hypothetical protein; Provisional; Region: PRK10396 395495002951 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 395495002952 SEC-C motif; Region: SEC-C; pfam02810 395495002953 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495002954 Ligand Binding Site [chemical binding]; other site 395495002955 PhoD-like phosphatase; Region: PhoD; pfam09423 395495002956 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 395495002957 putative active site [active] 395495002958 putative metal binding site [ion binding]; other site 395495002959 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395495002960 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 395495002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495002962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495002963 dimerization interface [polypeptide binding]; other site 395495002964 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 395495002965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495002966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 395495002967 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 395495002968 catalytic residues [active] 395495002969 catalytic nucleophile [active] 395495002970 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 395495002971 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 395495002972 Int/Topo IB signature motif; other site 395495002973 Transposase domain (DUF772); Region: DUF772; pfam05598 395495002974 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395495002975 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 395495002976 phosphoglycolate phosphatase; Provisional; Region: PRK13222 395495002977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495002978 motif II; other site 395495002979 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 395495002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495002981 S-adenosylmethionine binding site [chemical binding]; other site 395495002982 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495002983 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495002984 ligand binding site [chemical binding]; other site 395495002985 DNA gyrase subunit A; Validated; Region: PRK05560 395495002986 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 395495002987 CAP-like domain; other site 395495002988 active site 395495002989 primary dimer interface [polypeptide binding]; other site 395495002990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002991 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002992 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002993 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002994 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002995 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 395495002996 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 395495002997 Chorismate mutase type II; Region: CM_2; smart00830 395495002998 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 395495002999 Prephenate dehydratase; Region: PDT; pfam00800 395495003000 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 395495003001 putative L-Phe binding site [chemical binding]; other site 395495003002 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 395495003003 prephenate dehydrogenase; Validated; Region: PRK08507 395495003004 bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860 395495003005 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 395495003006 hinge; other site 395495003007 active site 395495003008 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 395495003009 CMP-binding site; other site 395495003010 The sites determining sugar specificity; other site 395495003011 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 395495003012 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 395495003013 RNA binding site [nucleotide binding]; other site 395495003014 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 395495003015 RNA binding site [nucleotide binding]; other site 395495003016 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 395495003017 RNA binding site [nucleotide binding]; other site 395495003018 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 395495003019 RNA binding site [nucleotide binding]; other site 395495003020 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 395495003021 RNA binding site [nucleotide binding]; other site 395495003022 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 395495003023 RNA binding site [nucleotide binding]; other site 395495003024 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395495003025 IHF dimer interface [polypeptide binding]; other site 395495003026 IHF - DNA interface [nucleotide binding]; other site 395495003027 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 395495003028 tetratricopeptide repeat protein; Provisional; Region: PRK11788 395495003029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495003030 binding surface 395495003031 TPR motif; other site 395495003032 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495003033 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 395495003034 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 395495003035 putative active site [active] 395495003036 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 395495003037 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395495003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495003039 S-adenosylmethionine binding site [chemical binding]; other site 395495003040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 395495003041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395495003042 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 395495003043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495003044 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 395495003045 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 395495003046 putative active site [active] 395495003047 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 395495003048 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 395495003049 nucleophile elbow; other site 395495003050 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 395495003051 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 395495003052 putative active site [active] 395495003053 putative PHP Thumb interface [polypeptide binding]; other site 395495003054 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 395495003055 generic binding surface II; other site 395495003056 generic binding surface I; other site 395495003057 rhodanese superfamily protein; Provisional; Region: PRK05320 395495003058 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395495003059 active site residue [active] 395495003060 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 395495003061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495003062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495003063 dimerization interface [polypeptide binding]; other site 395495003064 GTPase RsgA; Reviewed; Region: PRK00098 395495003065 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 395495003066 RNA binding site [nucleotide binding]; other site 395495003067 homodimer interface [polypeptide binding]; other site 395495003068 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 395495003069 GTPase/Zn-binding domain interface [polypeptide binding]; other site 395495003070 GTP/Mg2+ binding site [chemical binding]; other site 395495003071 G4 box; other site 395495003072 G5 box; other site 395495003073 G1 box; other site 395495003074 Switch I region; other site 395495003075 G2 box; other site 395495003076 G3 box; other site 395495003077 Switch II region; other site 395495003078 Peptidase family M48; Region: Peptidase_M48; pfam01435 395495003079 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 395495003080 catalytic site [active] 395495003081 putative active site [active] 395495003082 putative substrate binding site [chemical binding]; other site 395495003083 dimer interface [polypeptide binding]; other site 395495003084 Transcriptional regulators [Transcription]; Region: MarR; COG1846 395495003085 MarR family; Region: MarR_2; pfam12802 395495003086 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395495003087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495003088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495003089 active site 395495003090 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495003091 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495003092 Walker A/P-loop; other site 395495003093 ATP binding site [chemical binding]; other site 395495003094 Q-loop/lid; other site 395495003095 ABC transporter signature motif; other site 395495003096 Walker B; other site 395495003097 D-loop; other site 395495003098 H-loop/switch region; other site 395495003099 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495003100 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495003101 TM-ABC transporter signature motif; other site 395495003102 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495003103 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495003104 Walker A/P-loop; other site 395495003105 ATP binding site [chemical binding]; other site 395495003106 Q-loop/lid; other site 395495003107 ABC transporter signature motif; other site 395495003108 Walker B; other site 395495003109 D-loop; other site 395495003110 H-loop/switch region; other site 395495003111 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495003112 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495003113 TM-ABC transporter signature motif; other site 395495003114 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395495003115 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 395495003116 putative ligand binding site [chemical binding]; other site 395495003117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495003118 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 395495003119 NAD binding site [chemical binding]; other site 395495003120 homodimer interface [polypeptide binding]; other site 395495003121 homotetramer interface [polypeptide binding]; other site 395495003122 active site 395495003123 feruloyl-CoA synthase; Reviewed; Region: PRK08180 395495003124 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 395495003125 acyl-activating enzyme (AAE) consensus motif; other site 395495003126 putative AMP binding site [chemical binding]; other site 395495003127 putative active site [active] 395495003128 putative CoA binding site [chemical binding]; other site 395495003129 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395495003130 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495003131 substrate binding site [chemical binding]; other site 395495003132 oxyanion hole (OAH) forming residues; other site 395495003133 trimer interface [polypeptide binding]; other site 395495003134 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 395495003135 active site 395495003136 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 395495003137 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395495003138 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 395495003139 FAD binding pocket [chemical binding]; other site 395495003140 FAD binding motif [chemical binding]; other site 395495003141 phosphate binding motif [ion binding]; other site 395495003142 beta-alpha-beta structure motif; other site 395495003143 NAD binding pocket [chemical binding]; other site 395495003144 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 395495003145 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 395495003146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495003147 active site 395495003148 phosphorylation site [posttranslational modification] 395495003149 intermolecular recognition site; other site 395495003150 dimerization interface [polypeptide binding]; other site 395495003151 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 395495003152 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 395495003153 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495003154 ligand binding site [chemical binding]; other site 395495003155 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 395495003156 flagellar motor protein MotA; Validated; Region: PRK09110 395495003157 Methyltransferase domain; Region: Methyltransf_18; pfam12847 395495003158 S-adenosylmethionine binding site [chemical binding]; other site 395495003159 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 395495003160 transcriptional activator FlhC; Provisional; Region: PRK12722 395495003161 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 395495003162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495003163 binding surface 395495003164 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395495003165 TPR motif; other site 395495003166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495003167 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 395495003168 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495003169 flagellin; Provisional; Region: PRK12802 395495003170 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 395495003171 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 395495003172 flagellin; Provisional; Region: PRK12802 395495003173 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 395495003174 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 395495003175 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 395495003176 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 395495003177 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 395495003178 Flagellar protein FliS; Region: FliS; cl00654 395495003179 Flagellar protein FliT; Region: FliT; pfam05400 395495003180 Flagellar regulator YcgR; Region: YcgR; pfam07317 395495003181 PilZ domain; Region: PilZ; pfam07238 395495003182 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 395495003183 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 395495003184 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 395495003185 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 395495003186 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 395495003187 FliG C-terminal domain; Region: FliG_C; pfam01706 395495003188 flagellar assembly protein H; Validated; Region: fliH; PRK05687 395495003189 Flagellar assembly protein FliH; Region: FliH; pfam02108 395495003190 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 395495003191 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 395495003192 Walker A motif/ATP binding site; other site 395495003193 Walker B motif; other site 395495003194 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 395495003195 Flagellar FliJ protein; Region: FliJ; pfam02050 395495003196 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 395495003197 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 395495003198 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 395495003199 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 395495003200 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 395495003201 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 395495003202 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 395495003203 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 395495003204 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 395495003205 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 395495003206 active pocket/dimerization site; other site 395495003207 active site 395495003208 phosphorylation site [posttranslational modification] 395495003209 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 395495003210 dimerization domain swap beta strand [polypeptide binding]; other site 395495003211 regulatory protein interface [polypeptide binding]; other site 395495003212 active site 395495003213 regulatory phosphorylation site [posttranslational modification]; other site 395495003214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 395495003215 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 395495003216 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 395495003217 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 395495003218 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 395495003219 Transposase; Region: HTH_Tnp_1; cl17663 395495003220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 395495003221 Integrase core domain; Region: rve; pfam00665 395495003222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 395495003223 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 395495003224 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 395495003225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495003226 Walker A motif; other site 395495003227 ATP binding site [chemical binding]; other site 395495003228 Walker B motif; other site 395495003229 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 395495003230 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 395495003231 active site 395495003232 catalytic site [active] 395495003233 substrate binding site [chemical binding]; other site 395495003234 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495003235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495003236 catalytic loop [active] 395495003237 iron binding site [ion binding]; other site 395495003238 chaperone protein HscA; Provisional; Region: hscA; PRK05183 395495003239 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 395495003240 nucleotide binding site [chemical binding]; other site 395495003241 putative NEF/HSP70 interaction site [polypeptide binding]; other site 395495003242 SBD interface [polypeptide binding]; other site 395495003243 co-chaperone HscB; Provisional; Region: hscB; PRK03578 395495003244 DnaJ domain; Region: DnaJ; pfam00226 395495003245 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 395495003246 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 395495003247 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 395495003248 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 395495003249 trimerization site [polypeptide binding]; other site 395495003250 active site 395495003251 cysteine desulfurase; Provisional; Region: PRK14012 395495003252 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 395495003253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495003254 catalytic residue [active] 395495003255 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 395495003256 Rrf2 family protein; Region: rrf2_super; TIGR00738 395495003257 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395495003258 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 395495003259 active site 395495003260 excinuclease ABC subunit B; Provisional; Region: PRK05298 395495003261 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495003262 ATP binding site [chemical binding]; other site 395495003263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395495003264 putative Mg++ binding site [ion binding]; other site 395495003265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495003266 nucleotide binding region [chemical binding]; other site 395495003267 ATP-binding site [chemical binding]; other site 395495003268 Ultra-violet resistance protein B; Region: UvrB; pfam12344 395495003269 UvrB/uvrC motif; Region: UVR; pfam02151 395495003270 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 395495003271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495003272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495003273 homodimer interface [polypeptide binding]; other site 395495003274 catalytic residue [active] 395495003275 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 395495003276 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 395495003277 NADP binding site [chemical binding]; other site 395495003278 dimer interface [polypeptide binding]; other site 395495003279 HDOD domain; Region: HDOD; pfam08668 395495003280 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 395495003281 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 395495003282 quinone interaction residues [chemical binding]; other site 395495003283 active site 395495003284 catalytic residues [active] 395495003285 FMN binding site [chemical binding]; other site 395495003286 substrate binding site [chemical binding]; other site 395495003287 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 395495003288 tetramer (dimer of dimers) interface [polypeptide binding]; other site 395495003289 active site 395495003290 dimer interface [polypeptide binding]; other site 395495003291 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 395495003292 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 395495003293 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 395495003294 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 395495003295 putative active site [active] 395495003296 putative substrate binding site [chemical binding]; other site 395495003297 ATP binding site [chemical binding]; other site 395495003298 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 395495003299 DNA polymerase I; Provisional; Region: PRK05755 395495003300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 395495003301 active site 395495003302 metal binding site 1 [ion binding]; metal-binding site 395495003303 putative 5' ssDNA interaction site; other site 395495003304 metal binding site 3; metal-binding site 395495003305 metal binding site 2 [ion binding]; metal-binding site 395495003306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 395495003307 putative DNA binding site [nucleotide binding]; other site 395495003308 putative metal binding site [ion binding]; other site 395495003309 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 395495003310 active site 395495003311 catalytic site [active] 395495003312 substrate binding site [chemical binding]; other site 395495003313 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 395495003314 active site 395495003315 DNA binding site [nucleotide binding] 395495003316 catalytic site [active] 395495003317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495003318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495003319 metal binding site [ion binding]; metal-binding site 395495003320 active site 395495003321 I-site; other site 395495003322 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 395495003323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495003324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495003325 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495003326 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 395495003327 PEP-CTERM motif; Region: VPEP; pfam07589 395495003328 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395495003329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495003330 P-loop; other site 395495003331 Magnesium ion binding site [ion binding]; other site 395495003332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495003333 Magnesium ion binding site [ion binding]; other site 395495003334 H+ Antiporter protein; Region: 2A0121; TIGR00900 395495003335 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 395495003336 UreF; Region: UreF; pfam01730 395495003337 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 395495003338 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 395495003339 dimer interface [polypeptide binding]; other site 395495003340 catalytic residues [active] 395495003341 Repair protein; Region: Repair_PSII; pfam04536 395495003342 Repair protein; Region: Repair_PSII; pfam04536 395495003343 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 395495003344 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395495003345 active site residue [active] 395495003346 urease subunit alpha; Reviewed; Region: ureC; PRK13207 395495003347 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 395495003348 subunit interactions [polypeptide binding]; other site 395495003349 active site 395495003350 flap region; other site 395495003351 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 395495003352 gamma-beta subunit interface [polypeptide binding]; other site 395495003353 alpha-beta subunit interface [polypeptide binding]; other site 395495003354 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 395495003355 alpha-gamma subunit interface [polypeptide binding]; other site 395495003356 beta-gamma subunit interface [polypeptide binding]; other site 395495003357 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 395495003358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495003359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495003360 dimer interface [polypeptide binding]; other site 395495003361 phosphorylation site [posttranslational modification] 395495003362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495003363 ATP binding site [chemical binding]; other site 395495003364 Mg2+ binding site [ion binding]; other site 395495003365 G-X-G motif; other site 395495003366 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495003367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495003368 active site 395495003369 phosphorylation site [posttranslational modification] 395495003370 intermolecular recognition site; other site 395495003371 dimerization interface [polypeptide binding]; other site 395495003372 Response regulator receiver domain; Region: Response_reg; pfam00072 395495003373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495003374 active site 395495003375 phosphorylation site [posttranslational modification] 395495003376 intermolecular recognition site; other site 395495003377 dimerization interface [polypeptide binding]; other site 395495003378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495003379 DNA binding residues [nucleotide binding] 395495003380 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495003381 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 395495003382 putative ligand binding site [chemical binding]; other site 395495003383 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495003384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495003385 TM-ABC transporter signature motif; other site 395495003386 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 395495003387 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495003388 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495003389 TM-ABC transporter signature motif; other site 395495003390 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 395495003391 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495003392 Walker A/P-loop; other site 395495003393 ATP binding site [chemical binding]; other site 395495003394 Q-loop/lid; other site 395495003395 ABC transporter signature motif; other site 395495003396 Walker B; other site 395495003397 D-loop; other site 395495003398 H-loop/switch region; other site 395495003399 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 395495003400 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495003401 Walker A/P-loop; other site 395495003402 ATP binding site [chemical binding]; other site 395495003403 Q-loop/lid; other site 395495003404 ABC transporter signature motif; other site 395495003405 Walker B; other site 395495003406 D-loop; other site 395495003407 H-loop/switch region; other site 395495003408 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 395495003409 PEP-CTERM motif; Region: VPEP; pfam07589 395495003410 PEP-CTERM motif; Region: VPEP; pfam07589 395495003411 UreD urease accessory protein; Region: UreD; pfam01774 395495003412 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 395495003413 DNA-binding site [nucleotide binding]; DNA binding site 395495003414 RNA-binding motif; other site 395495003415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395495003416 nucleoside/Zn binding site; other site 395495003417 dimer interface [polypeptide binding]; other site 395495003418 catalytic motif [active] 395495003419 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 395495003420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495003421 dimer interface [polypeptide binding]; other site 395495003422 conserved gate region; other site 395495003423 putative PBP binding loops; other site 395495003424 ABC-ATPase subunit interface; other site 395495003425 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 395495003426 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 395495003427 Walker A/P-loop; other site 395495003428 ATP binding site [chemical binding]; other site 395495003429 Q-loop/lid; other site 395495003430 ABC transporter signature motif; other site 395495003431 Walker B; other site 395495003432 D-loop; other site 395495003433 H-loop/switch region; other site 395495003434 NMT1/THI5 like; Region: NMT1; pfam09084 395495003435 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 395495003436 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 395495003437 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 395495003438 putative metal binding site [ion binding]; other site 395495003439 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 395495003440 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 395495003441 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 395495003442 active site 395495003443 metal binding site [ion binding]; metal-binding site 395495003444 dimer interface [polypeptide binding]; other site 395495003445 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 395495003446 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 395495003447 active site 395495003448 catalytic site [active] 395495003449 tetramer interface [polypeptide binding]; other site 395495003450 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395495003451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495003452 DNA-binding site [nucleotide binding]; DNA binding site 395495003453 FCD domain; Region: FCD; pfam07729 395495003454 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 395495003455 active site 395495003456 homotetramer interface [polypeptide binding]; other site 395495003457 Protein of unknown function (DUF989); Region: DUF989; pfam06181 395495003458 Predicted membrane protein [Function unknown]; Region: COG3748 395495003459 Cytochrome c; Region: Cytochrom_C; pfam00034 395495003460 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 395495003461 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 395495003462 PhoU domain; Region: PhoU; pfam01895 395495003463 PhoU domain; Region: PhoU; pfam01895 395495003464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495003465 dimerization interface [polypeptide binding]; other site 395495003466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495003467 dimer interface [polypeptide binding]; other site 395495003468 putative CheW interface [polypeptide binding]; other site 395495003469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495003470 dimerization interface [polypeptide binding]; other site 395495003471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495003472 metal binding site [ion binding]; metal-binding site 395495003473 active site 395495003474 I-site; other site 395495003475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495003476 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 395495003477 Helix-turn-helix domain; Region: HTH_18; pfam12833 395495003478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495003479 AlkA N-terminal domain; Region: AlkA_N; pfam06029 395495003480 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 395495003481 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395495003482 minor groove reading motif; other site 395495003483 helix-hairpin-helix signature motif; other site 395495003484 substrate binding pocket [chemical binding]; other site 395495003485 active site 395495003486 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 395495003487 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 395495003488 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 395495003489 DNA binding site [nucleotide binding] 395495003490 active site 395495003491 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495003492 EamA-like transporter family; Region: EamA; pfam00892 395495003493 EamA-like transporter family; Region: EamA; pfam00892 395495003494 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 395495003495 DctM-like transporters; Region: DctM; pfam06808 395495003496 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495003497 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 395495003498 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495003499 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495003500 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495003501 extended (e) SDRs; Region: SDR_e; cd08946 395495003502 NAD(P) binding site [chemical binding]; other site 395495003503 active site 395495003504 substrate binding site [chemical binding]; other site 395495003505 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395495003506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495003507 DNA-binding site [nucleotide binding]; DNA binding site 395495003508 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 395495003509 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 395495003510 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 395495003511 putative active site [active] 395495003512 catalytic residue [active] 395495003513 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 395495003514 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 395495003515 active site 395495003516 tetramer interface [polypeptide binding]; other site 395495003517 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 395495003518 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495003519 NAD(P) binding site [chemical binding]; other site 395495003520 catalytic residues [active] 395495003521 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495003522 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 395495003523 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 395495003524 putative ligand binding site [chemical binding]; other site 395495003525 NAD binding site [chemical binding]; other site 395495003526 catalytic site [active] 395495003527 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 395495003528 tartronate semialdehyde reductase; Provisional; Region: PRK15059 395495003529 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395495003530 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495003531 Type II/IV secretion system protein; Region: T2SE; pfam00437 395495003532 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495003533 Walker A motif; other site 395495003534 ATP binding site [chemical binding]; other site 395495003535 Walker B motif; other site 395495003536 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 395495003537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495003538 Mg2+ binding site [ion binding]; other site 395495003539 G-X-G motif; other site 395495003540 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 395495003541 ATP binding site [chemical binding]; other site 395495003542 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 395495003543 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495003544 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495003545 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 395495003546 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 395495003547 AMIN domain; Region: AMIN; pfam11741 395495003548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 395495003549 active site 395495003550 metal binding site [ion binding]; metal-binding site 395495003551 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 395495003552 epoxyqueuosine reductase; Region: TIGR00276 395495003553 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 395495003554 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 395495003555 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 395495003556 MOFRL family; Region: MOFRL; pfam05161 395495003557 tartronate semialdehyde reductase; Provisional; Region: PRK15059 395495003558 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395495003559 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 395495003560 glyoxylate carboligase; Provisional; Region: PRK11269 395495003561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395495003562 PYR/PP interface [polypeptide binding]; other site 395495003563 dimer interface [polypeptide binding]; other site 395495003564 TPP binding site [chemical binding]; other site 395495003565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395495003566 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 395495003567 TPP-binding site [chemical binding]; other site 395495003568 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395495003569 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 395495003570 FAD binding pocket [chemical binding]; other site 395495003571 FAD binding motif [chemical binding]; other site 395495003572 phosphate binding motif [ion binding]; other site 395495003573 beta-alpha-beta structure motif; other site 395495003574 NAD binding pocket [chemical binding]; other site 395495003575 Heme binding pocket [chemical binding]; other site 395495003576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495003577 catalytic loop [active] 395495003578 iron binding site [ion binding]; other site 395495003579 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 395495003580 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 395495003581 active site 395495003582 putative substrate binding pocket [chemical binding]; other site 395495003583 xanthine permease; Region: pbuX; TIGR03173 395495003584 Protein of unknown function (DUF989); Region: DUF989; pfam06181 395495003585 Predicted membrane protein [Function unknown]; Region: COG3748 395495003586 Cytochrome c; Region: Cytochrom_C; pfam00034 395495003587 Predicted permeases [General function prediction only]; Region: COG0679 395495003588 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 395495003589 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 395495003590 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495003591 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495003592 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 395495003593 active site 395495003594 DNA binding site [nucleotide binding] 395495003595 Int/Topo IB signature motif; other site 395495003596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495003597 dimer interface [polypeptide binding]; other site 395495003598 conserved gate region; other site 395495003599 putative PBP binding loops; other site 395495003600 ABC-ATPase subunit interface; other site 395495003601 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395495003602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495003603 substrate binding pocket [chemical binding]; other site 395495003604 membrane-bound complex binding site; other site 395495003605 hinge residues; other site 395495003606 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 395495003607 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 395495003608 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 395495003609 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 395495003610 Putative addiction module component; Region: Unstab_antitox; pfam09720 395495003611 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 395495003612 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 395495003613 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 395495003614 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 395495003615 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 395495003616 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 395495003617 DEAD/DEAH box helicase; Region: DEAD; pfam00270 395495003618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395495003619 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 395495003620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495003621 putative CheW interface [polypeptide binding]; other site 395495003622 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 395495003623 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 395495003624 dimerization interface [polypeptide binding]; other site 395495003625 domain crossover interface; other site 395495003626 redox-dependent activation switch; other site 395495003627 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 395495003628 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 395495003629 trimer interface [polypeptide binding]; other site 395495003630 putative metal binding site [ion binding]; other site 395495003631 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 395495003632 dinuclear metal binding motif [ion binding]; other site 395495003633 Ion channel; Region: Ion_trans_2; pfam07885 395495003634 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 395495003635 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395495003636 putative metal binding site [ion binding]; other site 395495003637 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 395495003638 FAD binding domain; Region: FAD_binding_4; pfam01565 395495003639 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 395495003640 FAD binding domain; Region: FAD_binding_4; pfam01565 395495003641 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 395495003642 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495003643 Cysteine-rich domain; Region: CCG; pfam02754 395495003644 Cysteine-rich domain; Region: CCG; pfam02754 395495003645 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 395495003646 Septum formation initiator; Region: DivIC; cl17659 395495003647 enolase; Provisional; Region: eno; PRK00077 395495003648 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 395495003649 dimer interface [polypeptide binding]; other site 395495003650 metal binding site [ion binding]; metal-binding site 395495003651 substrate binding pocket [chemical binding]; other site 395495003652 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 395495003653 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 395495003654 CTP synthetase; Validated; Region: pyrG; PRK05380 395495003655 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 395495003656 Catalytic site [active] 395495003657 active site 395495003658 UTP binding site [chemical binding]; other site 395495003659 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 395495003660 active site 395495003661 putative oxyanion hole; other site 395495003662 catalytic triad [active] 395495003663 Pantoate-beta-alanine ligase; Region: PanC; cd00560 395495003664 pantoate--beta-alanine ligase; Region: panC; TIGR00018 395495003665 active site 395495003666 ATP-binding site [chemical binding]; other site 395495003667 pantoate-binding site; other site 395495003668 HXXH motif; other site 395495003669 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 395495003670 oligomerization interface [polypeptide binding]; other site 395495003671 active site 395495003672 metal binding site [ion binding]; metal-binding site 395495003673 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 395495003674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 395495003675 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 395495003676 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 395495003677 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 395495003678 MutS domain I; Region: MutS_I; pfam01624 395495003679 MutS domain II; Region: MutS_II; pfam05188 395495003680 MutS domain III; Region: MutS_III; pfam05192 395495003681 MutS domain V; Region: MutS_V; pfam00488 395495003682 Walker A/P-loop; other site 395495003683 ATP binding site [chemical binding]; other site 395495003684 Q-loop/lid; other site 395495003685 ABC transporter signature motif; other site 395495003686 Walker B; other site 395495003687 D-loop; other site 395495003688 H-loop/switch region; other site 395495003689 Predicted membrane protein [Function unknown]; Region: COG3174 395495003690 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 395495003691 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395495003692 MarR family; Region: MarR_2; pfam12802 395495003693 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 395495003694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495003695 NAD(P) binding site [chemical binding]; other site 395495003696 active site 395495003697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495003698 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 395495003699 substrate binding site [chemical binding]; other site 395495003700 oxyanion hole (OAH) forming residues; other site 395495003701 trimer interface [polypeptide binding]; other site 395495003702 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 395495003703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495003704 active site 395495003705 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 395495003706 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 395495003707 acyl-activating enzyme (AAE) consensus motif; other site 395495003708 putative AMP binding site [chemical binding]; other site 395495003709 putative active site [active] 395495003710 putative CoA binding site [chemical binding]; other site 395495003711 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495003712 enoyl-CoA hydratase; Provisional; Region: PRK05862 395495003713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495003714 substrate binding site [chemical binding]; other site 395495003715 oxyanion hole (OAH) forming residues; other site 395495003716 trimer interface [polypeptide binding]; other site 395495003717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495003718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495003719 active site 395495003720 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395495003721 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395495003722 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 395495003723 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 395495003724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495003725 FAD binding site [chemical binding]; other site 395495003726 substrate binding pocket [chemical binding]; other site 395495003727 catalytic base [active] 395495003728 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495003729 Ligand binding site [chemical binding]; other site 395495003730 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495003731 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495003732 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495003733 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495003734 enoyl-CoA hydratase; Provisional; Region: PRK05995 395495003735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495003736 substrate binding site [chemical binding]; other site 395495003737 oxyanion hole (OAH) forming residues; other site 395495003738 trimer interface [polypeptide binding]; other site 395495003739 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 395495003740 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395495003741 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495003742 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495003743 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 395495003744 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495003745 dimer interface [polypeptide binding]; other site 395495003746 active site 395495003747 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 395495003748 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 395495003749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495003750 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 395495003751 classical (c) SDRs; Region: SDR_c; cd05233 395495003752 NAD(P) binding site [chemical binding]; other site 395495003753 active site 395495003754 putative succinate dehydrogenase; Reviewed; Region: PRK12842 395495003755 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 395495003756 NIPSNAP; Region: NIPSNAP; pfam07978 395495003757 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495003758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495003759 NAD(P) binding site [chemical binding]; other site 395495003760 active site 395495003761 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495003762 TM-ABC transporter signature motif; other site 395495003763 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495003764 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495003765 TM-ABC transporter signature motif; other site 395495003766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495003767 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495003768 Walker A/P-loop; other site 395495003769 ATP binding site [chemical binding]; other site 395495003770 Q-loop/lid; other site 395495003771 ABC transporter signature motif; other site 395495003772 Walker B; other site 395495003773 D-loop; other site 395495003774 H-loop/switch region; other site 395495003775 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495003776 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495003777 Walker A/P-loop; other site 395495003778 ATP binding site [chemical binding]; other site 395495003779 Q-loop/lid; other site 395495003780 ABC transporter signature motif; other site 395495003781 Walker B; other site 395495003782 D-loop; other site 395495003783 H-loop/switch region; other site 395495003784 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495003785 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 395495003786 putative ligand binding site [chemical binding]; other site 395495003787 Hemerythrin-like domain; Region: Hr-like; cd12108 395495003788 Fe binding site [ion binding]; other site 395495003789 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 395495003790 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 395495003791 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 395495003792 Coenzyme A transferase; Region: CoA_trans; smart00882 395495003793 Coenzyme A transferase; Region: CoA_trans; cl17247 395495003794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495003795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495003796 active site 395495003797 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495003798 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 395495003799 ligand binding site [chemical binding]; other site 395495003800 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495003801 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495003802 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495003803 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 395495003804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495003805 classical (c) SDRs; Region: SDR_c; cd05233 395495003806 NAD(P) binding site [chemical binding]; other site 395495003807 active site 395495003808 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 395495003809 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 395495003810 active site 395495003811 dimerization interface [polypeptide binding]; other site 395495003812 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 395495003813 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 395495003814 serine O-acetyltransferase; Region: cysE; TIGR01172 395495003815 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 395495003816 trimer interface [polypeptide binding]; other site 395495003817 active site 395495003818 substrate binding site [chemical binding]; other site 395495003819 CoA binding site [chemical binding]; other site 395495003820 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 395495003821 MPT binding site; other site 395495003822 trimer interface [polypeptide binding]; other site 395495003823 Protein of unknown function (DUF615); Region: DUF615; pfam04751 395495003824 peptidase PmbA; Provisional; Region: PRK11040 395495003825 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495003826 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495003827 EamA-like transporter family; Region: EamA; pfam00892 395495003828 short chain dehydrogenase; Provisional; Region: PRK08339 395495003829 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 395495003830 putative NAD(P) binding site [chemical binding]; other site 395495003831 putative active site [active] 395495003832 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495003833 EamA-like transporter family; Region: EamA; pfam00892 395495003834 EamA-like transporter family; Region: EamA; pfam00892 395495003835 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 395495003836 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 395495003837 NADP binding site [chemical binding]; other site 395495003838 dimer interface [polypeptide binding]; other site 395495003839 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 395495003840 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 395495003841 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 395495003842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495003843 metal binding site [ion binding]; metal-binding site 395495003844 active site 395495003845 I-site; other site 395495003846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495003847 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 395495003848 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 395495003849 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 395495003850 lipoprotein signal peptidase; Provisional; Region: PRK14787 395495003851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495003852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495003853 active site 395495003854 catalytic tetrad [active] 395495003855 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 395495003856 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495003857 active site 395495003858 HIGH motif; other site 395495003859 nucleotide binding site [chemical binding]; other site 395495003860 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 395495003861 active site 395495003862 KMSKS motif; other site 395495003863 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 395495003864 tRNA binding surface [nucleotide binding]; other site 395495003865 anticodon binding site; other site 395495003866 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 395495003867 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 395495003868 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 395495003869 active site 395495003870 Riboflavin kinase; Region: Flavokinase; smart00904 395495003871 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 395495003872 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 395495003873 active site 395495003874 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 395495003875 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 395495003876 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 395495003877 active site 395495003878 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 395495003879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495003880 active site 395495003881 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 395495003882 catalytic motif [active] 395495003883 Catalytic residue [active] 395495003884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 395495003885 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 395495003886 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 395495003887 FAD binding domain; Region: FAD_binding_4; pfam01565 395495003888 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 395495003889 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 395495003890 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 395495003891 Sporulation related domain; Region: SPOR; pfam05036 395495003892 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 395495003893 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 395495003894 FMN binding site [chemical binding]; other site 395495003895 active site 395495003896 substrate binding site [chemical binding]; other site 395495003897 catalytic residue [active] 395495003898 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 395495003899 putative catalytic site [active] 395495003900 putative phosphate binding site [ion binding]; other site 395495003901 active site 395495003902 metal binding site A [ion binding]; metal-binding site 395495003903 DNA binding site [nucleotide binding] 395495003904 putative AP binding site [nucleotide binding]; other site 395495003905 putative metal binding site B [ion binding]; other site 395495003906 DNA photolyase; Region: DNA_photolyase; pfam00875 395495003907 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 395495003908 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 395495003909 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 395495003910 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 395495003911 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 395495003912 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395495003913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495003914 S-adenosylmethionine binding site [chemical binding]; other site 395495003915 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395495003916 active site residue [active] 395495003917 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495003918 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495003919 ligand binding site [chemical binding]; other site 395495003920 flexible hinge region; other site 395495003921 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 395495003922 Chorismate lyase; Region: Chor_lyase; cl01230 395495003923 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 395495003924 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495003925 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495003926 trimer interface [polypeptide binding]; other site 395495003927 eyelet of channel; other site 395495003928 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 395495003929 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 395495003930 folate binding site [chemical binding]; other site 395495003931 NADP+ binding site [chemical binding]; other site 395495003932 thymidylate synthase; Reviewed; Region: thyA; PRK01827 395495003933 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 395495003934 dimerization interface [polypeptide binding]; other site 395495003935 active site 395495003936 PilZ domain; Region: PilZ; pfam07238 395495003937 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 395495003938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495003939 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 395495003940 Walker A/P-loop; other site 395495003941 ATP binding site [chemical binding]; other site 395495003942 Q-loop/lid; other site 395495003943 ABC transporter signature motif; other site 395495003944 Walker B; other site 395495003945 D-loop; other site 395495003946 H-loop/switch region; other site 395495003947 Outer membrane efflux protein; Region: OEP; pfam02321 395495003948 Outer membrane efflux protein; Region: OEP; pfam02321 395495003949 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 395495003950 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 395495003951 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395495003952 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 395495003953 Predicted metal-binding protein [General function prediction only]; Region: COG3019 395495003954 Anti-sigma-K factor rskA; Region: RskA; pfam10099 395495003955 RNA polymerase sigma factor; Provisional; Region: PRK12537 395495003956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495003957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495003958 DNA binding residues [nucleotide binding] 395495003959 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 395495003960 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 395495003961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395495003962 Walker A/P-loop; other site 395495003963 ATP binding site [chemical binding]; other site 395495003964 Q-loop/lid; other site 395495003965 ABC transporter signature motif; other site 395495003966 Walker B; other site 395495003967 D-loop; other site 395495003968 H-loop/switch region; other site 395495003969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395495003970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395495003971 Walker A/P-loop; other site 395495003972 ATP binding site [chemical binding]; other site 395495003973 Q-loop/lid; other site 395495003974 ABC transporter signature motif; other site 395495003975 Walker B; other site 395495003976 D-loop; other site 395495003977 H-loop/switch region; other site 395495003978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395495003979 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 395495003980 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 395495003981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495003982 dimer interface [polypeptide binding]; other site 395495003983 conserved gate region; other site 395495003984 putative PBP binding loops; other site 395495003985 ABC-ATPase subunit interface; other site 395495003986 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 395495003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495003988 dimer interface [polypeptide binding]; other site 395495003989 conserved gate region; other site 395495003990 ABC-ATPase subunit interface; other site 395495003991 Protein of unknown function DUF86; Region: DUF86; pfam01934 395495003992 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395495003993 active site 395495003994 NTP binding site [chemical binding]; other site 395495003995 metal binding triad [ion binding]; metal-binding site 395495003996 antibiotic binding site [chemical binding]; other site 395495003997 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 395495003998 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 395495003999 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 395495004000 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 395495004001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395495004002 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 395495004003 Cupin domain; Region: Cupin_2; cl17218 395495004004 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 395495004005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495004006 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 395495004007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495004008 Walker A/P-loop; other site 395495004009 ATP binding site [chemical binding]; other site 395495004010 Q-loop/lid; other site 395495004011 ABC transporter signature motif; other site 395495004012 Walker B; other site 395495004013 D-loop; other site 395495004014 H-loop/switch region; other site 395495004015 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 395495004016 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 395495004017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495004018 putative substrate translocation pore; other site 395495004019 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 395495004020 putative active site [active] 395495004021 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 395495004022 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 395495004023 putative FMN binding site [chemical binding]; other site 395495004024 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495004025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495004026 enoyl-CoA hydratase; Provisional; Region: PRK06127 395495004027 substrate binding site [chemical binding]; other site 395495004028 oxyanion hole (OAH) forming residues; other site 395495004029 trimer interface [polypeptide binding]; other site 395495004030 malonyl-CoA synthase; Validated; Region: PRK07514 395495004031 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 395495004032 acyl-activating enzyme (AAE) consensus motif; other site 395495004033 active site 395495004034 AMP binding site [chemical binding]; other site 395495004035 CoA binding site [chemical binding]; other site 395495004036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004037 PAS domain; Region: PAS_9; pfam13426 395495004038 putative active site [active] 395495004039 heme pocket [chemical binding]; other site 395495004040 HAMP domain; Region: HAMP; pfam00672 395495004041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004042 dimer interface [polypeptide binding]; other site 395495004043 putative CheW interface [polypeptide binding]; other site 395495004044 PAS domain S-box; Region: sensory_box; TIGR00229 395495004045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004046 putative active site [active] 395495004047 heme pocket [chemical binding]; other site 395495004048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495004049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495004050 metal binding site [ion binding]; metal-binding site 395495004051 active site 395495004052 I-site; other site 395495004053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495004054 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 395495004055 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 395495004056 TrkA-N domain; Region: TrkA_N; pfam02254 395495004057 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 395495004058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395495004059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495004060 P-loop; other site 395495004061 Magnesium ion binding site [ion binding]; other site 395495004062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495004063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004064 active site 395495004065 phosphorylation site [posttranslational modification] 395495004066 intermolecular recognition site; other site 395495004067 dimerization interface [polypeptide binding]; other site 395495004068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495004069 DNA binding residues [nucleotide binding] 395495004070 dimerization interface [polypeptide binding]; other site 395495004071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495004072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495004073 dimer interface [polypeptide binding]; other site 395495004074 phosphorylation site [posttranslational modification] 395495004075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004076 ATP binding site [chemical binding]; other site 395495004077 Mg2+ binding site [ion binding]; other site 395495004078 G-X-G motif; other site 395495004079 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004081 active site 395495004082 phosphorylation site [posttranslational modification] 395495004083 intermolecular recognition site; other site 395495004084 dimerization interface [polypeptide binding]; other site 395495004085 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 395495004086 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 395495004087 homodimer interface [polypeptide binding]; other site 395495004088 substrate-cofactor binding pocket; other site 395495004089 catalytic residue [active] 395495004090 Zinc-finger domain; Region: zf-CHCC; cl01821 395495004091 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 395495004092 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 395495004093 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 395495004094 putative active site [active] 395495004095 putative substrate binding site [chemical binding]; other site 395495004096 putative cosubstrate binding site; other site 395495004097 catalytic site [active] 395495004098 SnoaL-like domain; Region: SnoaL_3; pfam13474 395495004099 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 395495004100 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 395495004101 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 395495004102 Cytochrome c; Region: Cytochrom_C; cl11414 395495004103 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 395495004104 DEAD-like helicases superfamily; Region: DEXDc; smart00487 395495004105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495004106 ATP binding site [chemical binding]; other site 395495004107 putative Mg++ binding site [ion binding]; other site 395495004108 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 395495004109 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 395495004110 HsdM N-terminal domain; Region: HsdM_N; pfam12161 395495004111 Methyltransferase domain; Region: Methyltransf_26; pfam13659 395495004112 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 395495004113 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395495004114 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 395495004115 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 395495004116 Abortive infection C-terminus; Region: Abi_C; pfam14355 395495004117 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495004118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495004119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495004120 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495004121 putative effector binding pocket; other site 395495004122 dimerization interface [polypeptide binding]; other site 395495004123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495004124 S-adenosylmethionine binding site [chemical binding]; other site 395495004125 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495004126 Cytochrome c; Region: Cytochrom_C; pfam00034 395495004127 Cytochrome c; Region: Cytochrom_C; cl11414 395495004128 Cytochrome c; Region: Cytochrom_C; cl11414 395495004129 Predicted permease; Region: DUF318; cl17795 395495004130 Predicted permease; Region: DUF318; cl17795 395495004131 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 395495004132 LrgA family; Region: LrgA; pfam03788 395495004133 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 395495004134 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 395495004135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495004136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495004137 DNA binding residues [nucleotide binding] 395495004138 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 395495004139 active site 395495004140 catalytic triad [active] 395495004141 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 395495004142 DctM-like transporters; Region: DctM; pfam06808 395495004143 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495004144 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 395495004145 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495004146 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495004147 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 395495004148 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 395495004149 FMN-binding pocket [chemical binding]; other site 395495004150 flavin binding motif; other site 395495004151 phosphate binding motif [ion binding]; other site 395495004152 beta-alpha-beta structure motif; other site 395495004153 NAD binding pocket [chemical binding]; other site 395495004154 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495004155 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495004156 catalytic loop [active] 395495004157 iron binding site [ion binding]; other site 395495004158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395495004159 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395495004160 iron-sulfur cluster [ion binding]; other site 395495004161 [2Fe-2S] cluster binding site [ion binding]; other site 395495004162 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 395495004163 alpha subunit interface [polypeptide binding]; other site 395495004164 active site 395495004165 substrate binding site [chemical binding]; other site 395495004166 Fe binding site [ion binding]; other site 395495004167 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 395495004168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495004169 DNA-binding site [nucleotide binding]; DNA binding site 395495004170 FCD domain; Region: FCD; pfam07729 395495004171 Cytochrome c; Region: Cytochrom_C; cl11414 395495004172 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 395495004173 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 395495004174 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 395495004175 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 395495004176 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 395495004177 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 395495004178 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395495004179 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495004180 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 395495004181 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 395495004182 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 395495004183 [4Fe-4S] binding site [ion binding]; other site 395495004184 molybdopterin cofactor binding site; other site 395495004185 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 395495004186 molybdopterin cofactor binding site; other site 395495004187 NapD protein; Region: NapD; pfam03927 395495004188 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 395495004189 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 395495004190 PAS domain; Region: PAS_9; pfam13426 395495004191 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 395495004192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004193 PAS domain; Region: PAS_9; pfam13426 395495004194 putative active site [active] 395495004195 heme pocket [chemical binding]; other site 395495004196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495004197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495004198 metal binding site [ion binding]; metal-binding site 395495004199 active site 395495004200 I-site; other site 395495004201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495004202 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 395495004203 nickel binding site [ion binding]; other site 395495004204 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 395495004205 hydrogenase 2 large subunit; Provisional; Region: PRK10467 395495004206 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 395495004207 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 395495004208 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 395495004209 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 395495004210 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 395495004211 probable nitrogen fixation protein; Region: TIGR02935 395495004212 Rop-like; Region: Rop-like; pfam05082 395495004213 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 395495004214 4Fe-4S binding domain; Region: Fer4; cl02805 395495004215 NifQ; Region: NifQ; pfam04891 395495004216 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 395495004217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395495004218 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 395495004219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495004220 dimer interface [polypeptide binding]; other site 395495004221 conserved gate region; other site 395495004222 putative PBP binding loops; other site 395495004223 ABC-ATPase subunit interface; other site 395495004224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495004225 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 395495004226 Walker A/P-loop; other site 395495004227 ATP binding site [chemical binding]; other site 395495004228 Q-loop/lid; other site 395495004229 ABC transporter signature motif; other site 395495004230 Walker B; other site 395495004231 D-loop; other site 395495004232 H-loop/switch region; other site 395495004233 TOBE domain; Region: TOBE; cl01440 395495004234 cysteine desulfurase; Provisional; Region: PRK14012 395495004235 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 395495004236 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495004237 catalytic residue [active] 395495004238 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 395495004239 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 395495004240 trimerization site [polypeptide binding]; other site 395495004241 active site 395495004242 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 395495004243 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 395495004244 chaperone protein HscA; Provisional; Region: hscA; PRK05183 395495004245 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 395495004246 nucleotide binding site [chemical binding]; other site 395495004247 putative NEF/HSP70 interaction site [polypeptide binding]; other site 395495004248 SBD interface [polypeptide binding]; other site 395495004249 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495004250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495004251 catalytic loop [active] 395495004252 iron binding site [ion binding]; other site 395495004253 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 395495004254 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 395495004255 active site 395495004256 catalytic residues [active] 395495004257 metal binding site [ion binding]; metal-binding site 395495004258 Nitrogen fixation protein NifW; Region: NifW; pfam03206 395495004259 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495004260 Ligand binding site [chemical binding]; other site 395495004261 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495004262 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495004263 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495004264 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495004265 oxidoreductase; Provisional; Region: PRK10015 395495004266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495004267 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 395495004268 Nif-specific regulatory protein; Region: nifA; TIGR01817 395495004269 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 395495004270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495004271 Walker A motif; other site 395495004272 ATP binding site [chemical binding]; other site 395495004273 Walker B motif; other site 395495004274 arginine finger; other site 395495004275 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495004276 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 395495004277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004278 active site 395495004279 phosphorylation site [posttranslational modification] 395495004280 intermolecular recognition site; other site 395495004281 dimerization interface [polypeptide binding]; other site 395495004282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495004283 DNA binding site [nucleotide binding] 395495004284 transcriptional regulator EpsA; Region: EpsA; TIGR03020 395495004285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495004286 DNA binding residues [nucleotide binding] 395495004287 dimerization interface [polypeptide binding]; other site 395495004288 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 395495004289 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 395495004290 chain length determinant protein EpsF; Region: EpsF; TIGR03017 395495004291 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 395495004292 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495004293 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 395495004294 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 395495004295 Interdomain contacts; other site 395495004296 Cytokine receptor motif; other site 395495004297 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 395495004298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395495004299 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395495004300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395495004301 active site 395495004302 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 395495004303 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 395495004304 Ligand binding site; other site 395495004305 metal-binding site 395495004306 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395495004307 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 395495004308 active site 395495004309 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 395495004310 active site 395495004311 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 395495004312 homodimer interface [polypeptide binding]; other site 395495004313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 395495004314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495004315 S-adenosylmethionine binding site [chemical binding]; other site 395495004316 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 395495004317 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 395495004318 Probable Catalytic site; other site 395495004319 metal-binding site 395495004320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395495004321 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 395495004322 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 395495004323 active site 395495004324 dimer interface [polypeptide binding]; other site 395495004325 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 395495004326 Ligand Binding Site [chemical binding]; other site 395495004327 Molecular Tunnel; other site 395495004328 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395495004329 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 395495004330 DXD motif; other site 395495004331 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932 395495004332 NodB motif; other site 395495004333 putative active site [active] 395495004334 putative catalytic site [active] 395495004335 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 395495004336 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 395495004337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495004338 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395495004339 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495004340 inhibitor-cofactor binding pocket; inhibition site 395495004341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004342 catalytic residue [active] 395495004343 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495004344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495004345 NAD(P) binding site [chemical binding]; other site 395495004346 active site 395495004347 Bacterial sugar transferase; Region: Bac_transf; pfam02397 395495004348 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 395495004349 putative trimer interface [polypeptide binding]; other site 395495004350 putative active site [active] 395495004351 putative substrate binding site [chemical binding]; other site 395495004352 putative CoA binding site [chemical binding]; other site 395495004353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495004354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495004355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495004356 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 395495004357 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495004358 inhibitor-cofactor binding pocket; inhibition site 395495004359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004360 catalytic residue [active] 395495004361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 395495004362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004364 active site 395495004365 phosphorylation site [posttranslational modification] 395495004366 intermolecular recognition site; other site 395495004367 dimerization interface [polypeptide binding]; other site 395495004368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495004369 DNA binding residues [nucleotide binding] 395495004370 dimerization interface [polypeptide binding]; other site 395495004371 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004373 active site 395495004374 phosphorylation site [posttranslational modification] 395495004375 intermolecular recognition site; other site 395495004376 dimerization interface [polypeptide binding]; other site 395495004377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395495004378 Histidine kinase; Region: HisKA_3; pfam07730 395495004379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004380 ATP binding site [chemical binding]; other site 395495004381 Mg2+ binding site [ion binding]; other site 395495004382 G-X-G motif; other site 395495004383 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495004384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004385 active site 395495004386 phosphorylation site [posttranslational modification] 395495004387 intermolecular recognition site; other site 395495004388 dimerization interface [polypeptide binding]; other site 395495004389 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495004390 DNA binding residues [nucleotide binding] 395495004391 dimerization interface [polypeptide binding]; other site 395495004392 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 395495004393 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495004394 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 395495004395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495004396 FeS/SAM binding site; other site 395495004397 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 395495004398 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 395495004399 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 395495004400 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 395495004401 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 395495004402 HEAT repeats; Region: HEAT_2; pfam13646 395495004403 NifZ domain; Region: NifZ; pfam04319 395495004404 NifZ domain; Region: NifZ; pfam04319 395495004405 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 395495004406 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 395495004407 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 395495004408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495004409 catalytic residue [active] 395495004410 NifT/FixU protein; Region: NifT; pfam06988 395495004411 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 395495004412 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 395495004413 inhibitor-cofactor binding pocket; inhibition site 395495004414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004415 catalytic residue [active] 395495004416 SIR2-like domain; Region: SIR2_2; pfam13289 395495004417 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495004418 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495004419 catalytic loop [active] 395495004420 iron binding site [ion binding]; other site 395495004421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495004422 Protein of unknown function DUF86; Region: DUF86; cl01031 395495004423 Short C-terminal domain; Region: SHOCT; pfam09851 395495004424 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 395495004425 catalytic core [active] 395495004426 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 395495004427 Immunoglobulin domain; Region: Ig; cl11960 395495004428 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 395495004429 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 395495004430 catalytic residues [active] 395495004431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495004432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495004433 metal binding site [ion binding]; metal-binding site 395495004434 active site 395495004435 I-site; other site 395495004436 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 395495004437 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 395495004438 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 395495004439 Nucleotide-binding sites [chemical binding]; other site 395495004440 Walker A motif; other site 395495004441 Switch I region of nucleotide binding site; other site 395495004442 Fe4S4 binding sites [ion binding]; other site 395495004443 Switch II region of nucleotide binding site; other site 395495004444 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 395495004445 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 395495004446 MoFe protein alpha/beta subunit interactions; other site 395495004447 Alpha subunit P cluster binding residues; other site 395495004448 FeMoco binding residues [chemical binding]; other site 395495004449 MoFe protein alpha subunit/Fe protein contacts; other site 395495004450 MoFe protein dimer/ dimer interactions; other site 395495004451 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 395495004452 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 395495004453 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 395495004454 MoFe protein beta/alpha subunit interactions; other site 395495004455 Beta subunit P cluster binding residues; other site 395495004456 MoFe protein beta subunit/Fe protein contacts; other site 395495004457 MoFe protein dimer/ dimer interactions; other site 395495004458 co-chaperone HscB; Provisional; Region: hscB; PRK03578 395495004459 DnaJ domain; Region: DnaJ; pfam00226 395495004460 HSP70 interaction site [polypeptide binding]; other site 395495004461 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 395495004462 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 395495004463 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495004464 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495004465 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 395495004466 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395495004467 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395495004468 shikimate binding site; other site 395495004469 NAD(P) binding site [chemical binding]; other site 395495004470 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495004471 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495004472 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 395495004473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495004474 NAD(P) binding site [chemical binding]; other site 395495004475 active site 395495004476 Predicted transcriptional regulators [Transcription]; Region: COG1733 395495004477 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 395495004478 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 395495004479 active site 395495004480 SAM binding site [chemical binding]; other site 395495004481 homodimer interface [polypeptide binding]; other site 395495004482 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495004483 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495004484 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 395495004485 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495004486 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495004487 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 395495004488 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495004489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495004490 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495004491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 395495004492 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 395495004493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495004494 FeS/SAM binding site; other site 395495004495 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495004496 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495004497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004498 putative active site [active] 395495004499 heme pocket [chemical binding]; other site 395495004500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495004501 dimer interface [polypeptide binding]; other site 395495004502 phosphorylation site [posttranslational modification] 395495004503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004504 ATP binding site [chemical binding]; other site 395495004505 Mg2+ binding site [ion binding]; other site 395495004506 G-X-G motif; other site 395495004507 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004509 active site 395495004510 phosphorylation site [posttranslational modification] 395495004511 intermolecular recognition site; other site 395495004512 dimerization interface [polypeptide binding]; other site 395495004513 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495004514 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495004515 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 395495004516 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 395495004517 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 395495004518 TPR repeat; Region: TPR_11; pfam13414 395495004519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495004520 TPR motif; other site 395495004521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495004522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495004523 ligand binding site [chemical binding]; other site 395495004524 flexible hinge region; other site 395495004525 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 395495004526 non-specific DNA interactions [nucleotide binding]; other site 395495004527 DNA binding site [nucleotide binding] 395495004528 sequence specific DNA binding site [nucleotide binding]; other site 395495004529 putative cAMP binding site [chemical binding]; other site 395495004530 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 395495004531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 395495004532 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 395495004533 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 395495004534 nickel binding site [ion binding]; other site 395495004535 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 395495004536 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 395495004537 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 395495004538 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495004539 catalytic loop [active] 395495004540 iron binding site [ion binding]; other site 395495004541 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 395495004542 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 395495004543 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 395495004544 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395495004545 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 395495004546 SLBB domain; Region: SLBB; pfam10531 395495004547 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 395495004548 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 395495004549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004550 active site 395495004551 phosphorylation site [posttranslational modification] 395495004552 intermolecular recognition site; other site 395495004553 dimerization interface [polypeptide binding]; other site 395495004554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495004555 Zn2+ binding site [ion binding]; other site 395495004556 Mg2+ binding site [ion binding]; other site 395495004557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004558 PAS fold; Region: PAS_3; pfam08447 395495004559 putative active site [active] 395495004560 heme pocket [chemical binding]; other site 395495004561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 395495004562 GAF domain; Region: GAF; pfam01590 395495004563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495004564 dimer interface [polypeptide binding]; other site 395495004565 phosphorylation site [posttranslational modification] 395495004566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004567 ATP binding site [chemical binding]; other site 395495004568 Mg2+ binding site [ion binding]; other site 395495004569 G-X-G motif; other site 395495004570 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004572 active site 395495004573 phosphorylation site [posttranslational modification] 395495004574 intermolecular recognition site; other site 395495004575 dimerization interface [polypeptide binding]; other site 395495004576 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 395495004577 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 395495004578 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 395495004579 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395495004580 MoxR-like ATPases [General function prediction only]; Region: COG0714 395495004581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495004582 Walker A motif; other site 395495004583 ATP binding site [chemical binding]; other site 395495004584 Walker B motif; other site 395495004585 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 395495004586 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 395495004587 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 395495004588 D-pathway; other site 395495004589 Putative water exit pathway; other site 395495004590 K-pathway; other site 395495004591 Binuclear center (active site) [active] 395495004592 Putative proton exit pathway; other site 395495004593 Cytochrome c; Region: Cytochrom_C; pfam00034 395495004594 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 395495004595 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 395495004596 Peptidase family U32; Region: Peptidase_U32; pfam01136 395495004597 putative protease; Provisional; Region: PRK15447 395495004598 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 395495004599 SCP-2 sterol transfer family; Region: SCP2; pfam02036 395495004600 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 395495004601 HPP family; Region: HPP; pfam04982 395495004602 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 395495004603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 395495004604 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 395495004605 NnrS protein; Region: NnrS; pfam05940 395495004606 Transcriptional regulator; Region: Rrf2; cl17282 395495004607 Rrf2 family protein; Region: rrf2_super; TIGR00738 395495004608 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 395495004609 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395495004610 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495004611 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 395495004612 NosL; Region: NosL; pfam05573 395495004613 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 395495004614 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395495004615 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395495004616 Walker A/P-loop; other site 395495004617 ATP binding site [chemical binding]; other site 395495004618 Q-loop/lid; other site 395495004619 ABC transporter signature motif; other site 395495004620 Walker B; other site 395495004621 D-loop; other site 395495004622 H-loop/switch region; other site 395495004623 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 395495004624 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 395495004625 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 395495004626 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 395495004627 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 395495004628 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395495004629 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 395495004630 nitrous-oxide reductase; Validated; Region: PRK02888 395495004631 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 395495004632 ApbE family; Region: ApbE; pfam02424 395495004633 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 395495004634 NnrS protein; Region: NnrS; cl01258 395495004635 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 395495004636 Cytochrome c; Region: Cytochrom_C; cl11414 395495004637 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 395495004638 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 395495004639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495004640 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 395495004641 putative dimerization interface [polypeptide binding]; other site 395495004642 putative substrate binding pocket [chemical binding]; other site 395495004643 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 395495004644 UGMP family protein; Validated; Region: PRK09604 395495004645 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495004646 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 395495004647 putative ligand binding site [chemical binding]; other site 395495004648 aspartate aminotransferase; Provisional; Region: PRK06108 395495004649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495004650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004651 homodimer interface [polypeptide binding]; other site 395495004652 catalytic residue [active] 395495004653 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 395495004654 16S/18S rRNA binding site [nucleotide binding]; other site 395495004655 S13e-L30e interaction site [polypeptide binding]; other site 395495004656 25S rRNA binding site [nucleotide binding]; other site 395495004657 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 395495004658 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 395495004659 RNase E interface [polypeptide binding]; other site 395495004660 trimer interface [polypeptide binding]; other site 395495004661 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 395495004662 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 395495004663 RNase E interface [polypeptide binding]; other site 395495004664 trimer interface [polypeptide binding]; other site 395495004665 active site 395495004666 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 395495004667 putative nucleic acid binding region [nucleotide binding]; other site 395495004668 G-X-X-G motif; other site 395495004669 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 395495004670 RNA binding site [nucleotide binding]; other site 395495004671 domain interface; other site 395495004672 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 395495004673 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 395495004674 NAD(P) binding site [chemical binding]; other site 395495004675 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 395495004676 substrate binding site [chemical binding]; other site 395495004677 dimer interface [polypeptide binding]; other site 395495004678 catalytic triad [active] 395495004679 Preprotein translocase SecG subunit; Region: SecG; pfam03840 395495004680 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 395495004681 NADH dehydrogenase subunit B; Validated; Region: PRK06411 395495004682 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 395495004683 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 395495004684 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 395495004685 NADH dehydrogenase subunit D; Validated; Region: PRK06075 395495004686 NADH dehydrogenase subunit E; Validated; Region: PRK07539 395495004687 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 395495004688 putative dimer interface [polypeptide binding]; other site 395495004689 [2Fe-2S] cluster binding site [ion binding]; other site 395495004690 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 395495004691 SLBB domain; Region: SLBB; pfam10531 395495004692 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 395495004693 NADH dehydrogenase subunit G; Validated; Region: PRK09129 395495004694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495004695 catalytic loop [active] 395495004696 iron binding site [ion binding]; other site 395495004697 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 395495004698 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 395495004699 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 395495004700 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 395495004701 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 395495004702 4Fe-4S binding domain; Region: Fer4; pfam00037 395495004703 4Fe-4S binding domain; Region: Fer4; pfam00037 395495004704 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 395495004705 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 395495004706 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 395495004707 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 395495004708 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 395495004709 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395495004710 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 395495004711 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395495004712 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 395495004713 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 395495004714 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 395495004715 dimer interface [polypeptide binding]; other site 395495004716 ADP-ribose binding site [chemical binding]; other site 395495004717 active site 395495004718 nudix motif; other site 395495004719 metal binding site [ion binding]; metal-binding site 395495004720 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 395495004721 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395495004722 FAD binding domain; Region: FAD_binding_4; pfam01565 395495004723 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 395495004724 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 395495004725 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 395495004726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004727 PAS domain; Region: PAS_9; pfam13426 395495004728 putative active site [active] 395495004729 heme pocket [chemical binding]; other site 395495004730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495004731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004732 dimer interface [polypeptide binding]; other site 395495004733 putative CheW interface [polypeptide binding]; other site 395495004734 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395495004735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395495004736 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 395495004737 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395495004738 homodimer interface [polypeptide binding]; other site 395495004739 substrate-cofactor binding pocket; other site 395495004740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004741 catalytic residue [active] 395495004742 FOG: CBS domain [General function prediction only]; Region: COG0517 395495004743 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 395495004744 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395495004745 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 395495004746 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 395495004747 Tetramer interface [polypeptide binding]; other site 395495004748 active site 395495004749 FMN-binding site [chemical binding]; other site 395495004750 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 395495004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004752 active site 395495004753 phosphorylation site [posttranslational modification] 395495004754 intermolecular recognition site; other site 395495004755 dimerization interface [polypeptide binding]; other site 395495004756 CheB methylesterase; Region: CheB_methylest; pfam01339 395495004757 CheD chemotactic sensory transduction; Region: CheD; cl00810 395495004758 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 395495004759 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 395495004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495004761 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 395495004762 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 395495004763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495004764 dimerization interface [polypeptide binding]; other site 395495004765 PAS domain; Region: PAS_9; pfam13426 395495004766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004767 dimer interface [polypeptide binding]; other site 395495004768 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 395495004769 putative CheW interface [polypeptide binding]; other site 395495004770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495004771 dimerization interface [polypeptide binding]; other site 395495004772 PAS fold; Region: PAS_4; pfam08448 395495004773 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 395495004774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004775 dimer interface [polypeptide binding]; other site 395495004776 putative CheW interface [polypeptide binding]; other site 395495004777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004778 PAS domain; Region: PAS_9; pfam13426 395495004779 putative active site [active] 395495004780 heme pocket [chemical binding]; other site 395495004781 PAS domain; Region: PAS_9; pfam13426 395495004782 PAS domain; Region: PAS; smart00091 395495004783 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004784 dimer interface [polypeptide binding]; other site 395495004785 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 395495004786 putative CheW interface [polypeptide binding]; other site 395495004787 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395495004788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495004789 putative binding surface; other site 395495004790 active site 395495004791 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395495004792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004793 ATP binding site [chemical binding]; other site 395495004794 Mg2+ binding site [ion binding]; other site 395495004795 G-X-G motif; other site 395495004796 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395495004797 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395495004798 anti sigma factor interaction site; other site 395495004799 regulatory phosphorylation site [posttranslational modification]; other site 395495004800 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004802 active site 395495004803 phosphorylation site [posttranslational modification] 395495004804 intermolecular recognition site; other site 395495004805 dimerization interface [polypeptide binding]; other site 395495004806 Response regulator receiver domain; Region: Response_reg; pfam00072 395495004807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004808 active site 395495004809 phosphorylation site [posttranslational modification] 395495004810 intermolecular recognition site; other site 395495004811 dimerization interface [polypeptide binding]; other site 395495004812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004813 dimer interface [polypeptide binding]; other site 395495004814 putative CheW interface [polypeptide binding]; other site 395495004815 HAMP domain; Region: HAMP; pfam00672 395495004816 dimerization interface [polypeptide binding]; other site 395495004817 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495004818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495004819 dimer interface [polypeptide binding]; other site 395495004820 putative CheW interface [polypeptide binding]; other site 395495004821 PAS domain; Region: PAS_9; pfam13426 395495004822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495004823 putative active site [active] 395495004824 heme pocket [chemical binding]; other site 395495004825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495004826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495004827 metal binding site [ion binding]; metal-binding site 395495004828 active site 395495004829 I-site; other site 395495004830 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 395495004831 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 395495004832 heme-binding residues [chemical binding]; other site 395495004833 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 395495004834 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 395495004835 Sporulation related domain; Region: SPOR; pfam05036 395495004836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495004837 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 395495004838 Walker A/P-loop; other site 395495004839 ATP binding site [chemical binding]; other site 395495004840 Q-loop/lid; other site 395495004841 ABC transporter signature motif; other site 395495004842 Walker B; other site 395495004843 D-loop; other site 395495004844 H-loop/switch region; other site 395495004845 CcmB protein; Region: CcmB; pfam03379 395495004846 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 395495004847 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 395495004848 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 395495004849 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 395495004850 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 395495004851 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495004852 catalytic residues [active] 395495004853 central insert; other site 395495004854 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 395495004855 TPR repeat; Region: TPR_11; pfam13414 395495004856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495004857 binding surface 395495004858 TPR motif; other site 395495004859 4Fe-4S binding domain; Region: Fer4_6; pfam12837 395495004860 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 395495004861 4Fe-4S binding domain; Region: Fer4; pfam00037 395495004862 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 395495004863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495004864 putative hydrolase; Provisional; Region: PRK11460 395495004865 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395495004866 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 395495004867 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 395495004868 tetramer interface [polypeptide binding]; other site 395495004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004870 catalytic residue [active] 395495004871 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 395495004872 Helix-turn-helix domain; Region: HTH_38; pfam13936 395495004873 Integrase core domain; Region: rve; pfam00665 395495004874 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 395495004875 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395495004876 XdhC Rossmann domain; Region: XdhC_C; pfam13478 395495004877 glycine dehydrogenase; Provisional; Region: PRK05367 395495004878 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395495004879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495004880 catalytic residue [active] 395495004881 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 395495004882 tetramer interface [polypeptide binding]; other site 395495004883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004884 catalytic residue [active] 395495004885 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 395495004886 lipoyl attachment site [posttranslational modification]; other site 395495004887 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 395495004888 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395495004889 recombination associated protein; Reviewed; Region: rdgC; PRK00321 395495004890 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 395495004891 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395495004892 active site 395495004893 metal binding site [ion binding]; metal-binding site 395495004894 DNA binding site [nucleotide binding] 395495004895 AAA domain; Region: AAA_27; pfam13514 395495004896 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 395495004897 putative active site [active] 395495004898 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 395495004899 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 395495004900 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 395495004901 Hemin uptake protein hemP; Region: hemP; pfam10636 395495004902 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 395495004903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395495004904 N-terminal plug; other site 395495004905 ligand-binding site [chemical binding]; other site 395495004906 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 395495004907 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 395495004908 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 395495004909 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495004910 TolR protein; Region: tolR; TIGR02801 395495004911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495004912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004913 active site 395495004914 phosphorylation site [posttranslational modification] 395495004915 intermolecular recognition site; other site 395495004916 dimerization interface [polypeptide binding]; other site 395495004917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495004918 DNA binding residues [nucleotide binding] 395495004919 dimerization interface [polypeptide binding]; other site 395495004920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495004921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495004922 dimer interface [polypeptide binding]; other site 395495004923 phosphorylation site [posttranslational modification] 395495004924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495004925 ATP binding site [chemical binding]; other site 395495004926 Mg2+ binding site [ion binding]; other site 395495004927 G-X-G motif; other site 395495004928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495004929 active site 395495004930 phosphorylation site [posttranslational modification] 395495004931 intermolecular recognition site; other site 395495004932 dimerization interface [polypeptide binding]; other site 395495004933 Cytochrome c; Region: Cytochrom_C; cl11414 395495004934 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 395495004935 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 395495004936 putative addiction module antidote; Region: doc_partner; TIGR02609 395495004937 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 395495004938 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 395495004939 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 395495004940 generic binding surface I; other site 395495004941 generic binding surface II; other site 395495004942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495004943 ATP binding site [chemical binding]; other site 395495004944 putative Mg++ binding site [ion binding]; other site 395495004945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495004946 nucleotide binding region [chemical binding]; other site 395495004947 ATP-binding site [chemical binding]; other site 395495004948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495004949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495004950 Bacterial transcriptional repressor; Region: TetR; pfam13972 395495004951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395495004952 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395495004953 Walker A/P-loop; other site 395495004954 ATP binding site [chemical binding]; other site 395495004955 Q-loop/lid; other site 395495004956 ABC transporter signature motif; other site 395495004957 Walker B; other site 395495004958 D-loop; other site 395495004959 H-loop/switch region; other site 395495004960 ABC-2 type transporter; Region: ABC2_membrane; cl17235 395495004961 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395495004962 BolA-like protein; Region: BolA; cl00386 395495004963 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 395495004964 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 395495004965 hinge; other site 395495004966 active site 395495004967 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 395495004968 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 395495004969 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 395495004970 histidinol dehydrogenase; Region: hisD; TIGR00069 395495004971 NAD binding site [chemical binding]; other site 395495004972 dimerization interface [polypeptide binding]; other site 395495004973 product binding site; other site 395495004974 substrate binding site [chemical binding]; other site 395495004975 zinc binding site [ion binding]; other site 395495004976 catalytic residues [active] 395495004977 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 395495004978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495004979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495004980 homodimer interface [polypeptide binding]; other site 395495004981 catalytic residue [active] 395495004982 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 395495004983 putative active site pocket [active] 395495004984 4-fold oligomerization interface [polypeptide binding]; other site 395495004985 metal binding residues [ion binding]; metal-binding site 395495004986 3-fold/trimer interface [polypeptide binding]; other site 395495004987 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 395495004988 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 395495004989 putative active site [active] 395495004990 oxyanion strand; other site 395495004991 catalytic triad [active] 395495004992 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 395495004993 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 395495004994 catalytic residues [active] 395495004995 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 395495004996 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 395495004997 substrate binding site [chemical binding]; other site 395495004998 glutamase interaction surface [polypeptide binding]; other site 395495004999 PEP-CTERM motif; Region: VPEP; pfam07589 395495005000 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495005001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005002 active site 395495005003 phosphorylation site [posttranslational modification] 395495005004 intermolecular recognition site; other site 395495005005 dimerization interface [polypeptide binding]; other site 395495005006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495005007 DNA binding residues [nucleotide binding] 395495005008 dimerization interface [polypeptide binding]; other site 395495005009 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495005010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005011 active site 395495005012 phosphorylation site [posttranslational modification] 395495005013 intermolecular recognition site; other site 395495005014 dimerization interface [polypeptide binding]; other site 395495005015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395495005016 Histidine kinase; Region: HisKA_3; pfam07730 395495005017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005018 ATP binding site [chemical binding]; other site 395495005019 Mg2+ binding site [ion binding]; other site 395495005020 G-X-G motif; other site 395495005021 Response regulator receiver domain; Region: Response_reg; pfam00072 395495005022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005023 active site 395495005024 phosphorylation site [posttranslational modification] 395495005025 intermolecular recognition site; other site 395495005026 dimerization interface [polypeptide binding]; other site 395495005027 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495005028 putative binding surface; other site 395495005029 active site 395495005030 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395495005031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005032 ATP binding site [chemical binding]; other site 395495005033 Mg2+ binding site [ion binding]; other site 395495005034 G-X-G motif; other site 395495005035 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395495005036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495005037 dimerization interface [polypeptide binding]; other site 395495005038 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495005039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495005040 dimer interface [polypeptide binding]; other site 395495005041 putative CheW interface [polypeptide binding]; other site 395495005042 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495005043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495005044 dimer interface [polypeptide binding]; other site 395495005045 putative CheW interface [polypeptide binding]; other site 395495005046 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 395495005047 FtsX-like permease family; Region: FtsX; pfam02687 395495005048 FtsX-like permease family; Region: FtsX; pfam02687 395495005049 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 395495005050 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 395495005051 putative active site [active] 395495005052 metal binding site [ion binding]; metal-binding site 395495005053 Uncharacterized conserved protein [Function unknown]; Region: COG0327 395495005054 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 395495005055 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495005056 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495005057 protein binding site [polypeptide binding]; other site 395495005058 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 395495005059 sec-independent translocase; Provisional; Region: tatB; PRK01919 395495005060 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 395495005061 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 395495005062 nucleotide binding site/active site [active] 395495005063 HIT family signature motif; other site 395495005064 catalytic residue [active] 395495005065 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 395495005066 metal binding site [ion binding]; metal-binding site 395495005067 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 395495005068 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 395495005069 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 395495005070 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 395495005071 UbiA prenyltransferase family; Region: UbiA; pfam01040 395495005072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005073 PAS domain; Region: PAS_9; pfam13426 395495005074 putative active site [active] 395495005075 heme pocket [chemical binding]; other site 395495005076 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005078 metal binding site [ion binding]; metal-binding site 395495005079 active site 395495005080 I-site; other site 395495005081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495005082 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 395495005083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495005084 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 395495005085 dimerization interface [polypeptide binding]; other site 395495005086 Cytochrome c; Region: Cytochrom_C; cl11414 395495005087 Cytochrome c; Region: Cytochrom_C; cl11414 395495005088 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 395495005089 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 395495005090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495005091 Zn2+ binding site [ion binding]; other site 395495005092 Mg2+ binding site [ion binding]; other site 395495005093 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 395495005094 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 395495005095 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 395495005096 FHIPEP family; Region: FHIPEP; pfam00771 395495005097 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 395495005098 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495005099 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 395495005100 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 395495005101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495005102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395495005103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495005104 DNA binding residues [nucleotide binding] 395495005105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495005106 dimer interface [polypeptide binding]; other site 395495005107 putative CheW interface [polypeptide binding]; other site 395495005108 Hemerythrin; Region: Hemerythrin; cd12107 395495005109 Fe binding site [ion binding]; other site 395495005110 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 395495005111 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 395495005112 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 395495005113 NAD(P) binding site [chemical binding]; other site 395495005114 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 395495005115 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 395495005116 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 395495005117 Proline dehydrogenase; Region: Pro_dh; cl03282 395495005118 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 395495005119 Glutamate binding site [chemical binding]; other site 395495005120 NAD binding site [chemical binding]; other site 395495005121 catalytic residues [active] 395495005122 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 395495005123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395495005124 putative DNA binding site [nucleotide binding]; other site 395495005125 putative Zn2+ binding site [ion binding]; other site 395495005126 AsnC family; Region: AsnC_trans_reg; pfam01037 395495005127 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 395495005128 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395495005129 catalytic residue [active] 395495005130 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 395495005131 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 395495005132 Walker A motif; other site 395495005133 ATP binding site [chemical binding]; other site 395495005134 Walker B motif; other site 395495005135 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 395495005136 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495005137 Walker A motif; other site 395495005138 ATP binding site [chemical binding]; other site 395495005139 Walker B motif; other site 395495005140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395495005141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005142 ATP binding site [chemical binding]; other site 395495005143 Mg2+ binding site [ion binding]; other site 395495005144 G-X-G motif; other site 395495005145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005147 active site 395495005148 phosphorylation site [posttranslational modification] 395495005149 intermolecular recognition site; other site 395495005150 dimerization interface [polypeptide binding]; other site 395495005151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495005152 DNA binding residues [nucleotide binding] 395495005153 dimerization interface [polypeptide binding]; other site 395495005154 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 395495005155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 395495005156 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 395495005157 BON domain; Region: BON; pfam04972 395495005158 BON domain; Region: BON; pfam04972 395495005159 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 395495005160 dimer interface [polypeptide binding]; other site 395495005161 active site 395495005162 hypothetical protein; Provisional; Region: PRK14673 395495005163 Predicted methyltransferases [General function prediction only]; Region: COG0313 395495005164 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 395495005165 putative SAM binding site [chemical binding]; other site 395495005166 putative homodimer interface [polypeptide binding]; other site 395495005167 MASE1; Region: MASE1; cl17823 395495005168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005169 PAS domain; Region: PAS_9; pfam13426 395495005170 putative active site [active] 395495005171 heme pocket [chemical binding]; other site 395495005172 PAS fold; Region: PAS_4; pfam08448 395495005173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005174 putative active site [active] 395495005175 heme pocket [chemical binding]; other site 395495005176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005178 metal binding site [ion binding]; metal-binding site 395495005179 active site 395495005180 I-site; other site 395495005181 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 395495005182 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 395495005183 active site 395495005184 Zn binding site [ion binding]; other site 395495005185 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 395495005186 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 395495005187 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 395495005188 homodimer interface [polypeptide binding]; other site 395495005189 NADP binding site [chemical binding]; other site 395495005190 substrate binding site [chemical binding]; other site 395495005191 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 395495005192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005193 active site 395495005194 phosphorylation site [posttranslational modification] 395495005195 intermolecular recognition site; other site 395495005196 dimerization interface [polypeptide binding]; other site 395495005197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495005198 DNA binding residues [nucleotide binding] 395495005199 dimerization interface [polypeptide binding]; other site 395495005200 PAS domain S-box; Region: sensory_box; TIGR00229 395495005201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005202 putative active site [active] 395495005203 heme pocket [chemical binding]; other site 395495005204 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495005205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495005206 dimer interface [polypeptide binding]; other site 395495005207 phosphorylation site [posttranslational modification] 395495005208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005209 ATP binding site [chemical binding]; other site 395495005210 Mg2+ binding site [ion binding]; other site 395495005211 G-X-G motif; other site 395495005212 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 395495005213 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 395495005214 dimer interface [polypeptide binding]; other site 395495005215 TPP-binding site [chemical binding]; other site 395495005216 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 395495005217 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395495005218 E3 interaction surface; other site 395495005219 lipoyl attachment site [posttranslational modification]; other site 395495005220 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395495005221 E3 interaction surface; other site 395495005222 lipoyl attachment site [posttranslational modification]; other site 395495005223 e3 binding domain; Region: E3_binding; pfam02817 395495005224 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 395495005225 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395495005226 E3 interaction surface; other site 395495005227 lipoyl attachment site [posttranslational modification]; other site 395495005228 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 395495005229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495005230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495005231 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395495005232 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495005233 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 395495005234 catalytic residues [active] 395495005235 ApbE family; Region: ApbE; pfam02424 395495005236 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 395495005237 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 395495005238 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 395495005239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005240 active site 395495005241 phosphorylation site [posttranslational modification] 395495005242 intermolecular recognition site; other site 395495005243 dimerization interface [polypeptide binding]; other site 395495005244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495005245 DNA binding site [nucleotide binding] 395495005246 PBP superfamily domain; Region: PBP_like_2; cl17296 395495005247 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 395495005248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005249 dimer interface [polypeptide binding]; other site 395495005250 conserved gate region; other site 395495005251 putative PBP binding loops; other site 395495005252 ABC-ATPase subunit interface; other site 395495005253 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 395495005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005255 dimer interface [polypeptide binding]; other site 395495005256 conserved gate region; other site 395495005257 putative PBP binding loops; other site 395495005258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395495005259 ABC-ATPase subunit interface; other site 395495005260 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 395495005261 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 395495005262 Walker A/P-loop; other site 395495005263 ATP binding site [chemical binding]; other site 395495005264 Q-loop/lid; other site 395495005265 ABC transporter signature motif; other site 395495005266 Walker B; other site 395495005267 D-loop; other site 395495005268 H-loop/switch region; other site 395495005269 transcriptional regulator PhoU; Provisional; Region: PRK11115 395495005270 PhoU domain; Region: PhoU; pfam01895 395495005271 PhoU domain; Region: PhoU; pfam01895 395495005272 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 395495005273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005274 active site 395495005275 phosphorylation site [posttranslational modification] 395495005276 intermolecular recognition site; other site 395495005277 dimerization interface [polypeptide binding]; other site 395495005278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495005279 DNA binding site [nucleotide binding] 395495005280 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 395495005281 putative FMN binding site [chemical binding]; other site 395495005282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 395495005283 DNA-binding site [nucleotide binding]; DNA binding site 395495005284 RNA-binding motif; other site 395495005285 Uncharacterized conserved protein [Function unknown]; Region: COG2127 395495005286 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 395495005287 Clp amino terminal domain; Region: Clp_N; pfam02861 395495005288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495005289 Walker A motif; other site 395495005290 ATP binding site [chemical binding]; other site 395495005291 Walker B motif; other site 395495005292 arginine finger; other site 395495005293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495005294 Walker A motif; other site 395495005295 ATP binding site [chemical binding]; other site 395495005296 Walker B motif; other site 395495005297 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 395495005298 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 395495005299 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 395495005300 putative active site [active] 395495005301 putative metal binding site [ion binding]; other site 395495005302 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 395495005303 substrate binding site [chemical binding]; other site 395495005304 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 395495005305 substrate binding site [chemical binding]; other site 395495005306 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 395495005307 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 395495005308 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395495005309 active site 395495005310 HIGH motif; other site 395495005311 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 395495005312 KMSKS motif; other site 395495005313 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 395495005314 tRNA binding surface [nucleotide binding]; other site 395495005315 anticodon binding site; other site 395495005316 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395495005317 endonuclease III; Region: ENDO3c; smart00478 395495005318 minor groove reading motif; other site 395495005319 helix-hairpin-helix signature motif; other site 395495005320 substrate binding pocket [chemical binding]; other site 395495005321 active site 395495005322 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 395495005323 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 395495005324 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 395495005325 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 395495005326 Ligand Binding Site [chemical binding]; other site 395495005327 TilS substrate binding domain; Region: TilS; pfam09179 395495005328 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 395495005329 aspartate kinase; Reviewed; Region: PRK06635 395495005330 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 395495005331 putative nucleotide binding site [chemical binding]; other site 395495005332 putative catalytic residues [active] 395495005333 putative Mg ion binding site [ion binding]; other site 395495005334 putative aspartate binding site [chemical binding]; other site 395495005335 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 395495005336 putative allosteric regulatory site; other site 395495005337 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 395495005338 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 395495005339 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 395495005340 substrate binding site [chemical binding]; other site 395495005341 ligand binding site [chemical binding]; other site 395495005342 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 395495005343 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 395495005344 substrate binding site [chemical binding]; other site 395495005345 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 395495005346 tartrate dehydrogenase; Region: TTC; TIGR02089 395495005347 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 395495005348 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 395495005349 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395495005350 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 395495005351 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 395495005352 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 395495005353 dimerization interface 3.5A [polypeptide binding]; other site 395495005354 active site 395495005355 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 395495005356 active site 395495005357 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 395495005358 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 395495005359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495005360 catalytic residue [active] 395495005361 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 395495005362 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 395495005363 substrate binding site [chemical binding]; other site 395495005364 active site 395495005365 catalytic residues [active] 395495005366 heterodimer interface [polypeptide binding]; other site 395495005367 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 395495005368 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395495005369 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 395495005370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495005371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495005372 Sporulation related domain; Region: SPOR; pfam05036 395495005373 Colicin V production protein; Region: Colicin_V; pfam02674 395495005374 amidophosphoribosyltransferase; Provisional; Region: PRK09246 395495005375 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 395495005376 active site 395495005377 tetramer interface [polypeptide binding]; other site 395495005378 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495005379 active site 395495005380 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 395495005381 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395495005382 homodimer interface [polypeptide binding]; other site 395495005383 substrate-cofactor binding pocket; other site 395495005384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495005385 catalytic residue [active] 395495005386 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 395495005387 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 395495005388 active site 395495005389 HIGH motif; other site 395495005390 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 395495005391 active site 395495005392 KMSKS motif; other site 395495005393 glucokinase; Provisional; Region: glk; PRK00292 395495005394 glucokinase, proteobacterial type; Region: glk; TIGR00749 395495005395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395495005396 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495005397 Walker A/P-loop; other site 395495005398 ATP binding site [chemical binding]; other site 395495005399 Q-loop/lid; other site 395495005400 ABC transporter signature motif; other site 395495005401 Walker B; other site 395495005402 D-loop; other site 395495005403 H-loop/switch region; other site 395495005404 TOBE domain; Region: TOBE_2; pfam08402 395495005405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495005406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005407 dimer interface [polypeptide binding]; other site 395495005408 conserved gate region; other site 395495005409 putative PBP binding loops; other site 395495005410 ABC-ATPase subunit interface; other site 395495005411 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395495005412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005413 dimer interface [polypeptide binding]; other site 395495005414 conserved gate region; other site 395495005415 putative PBP binding loops; other site 395495005416 ABC-ATPase subunit interface; other site 395495005417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395495005418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495005419 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 395495005420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495005421 HAMP domain; Region: HAMP; pfam00672 395495005422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495005423 dimer interface [polypeptide binding]; other site 395495005424 phosphorylation site [posttranslational modification] 395495005425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005426 ATP binding site [chemical binding]; other site 395495005427 Mg2+ binding site [ion binding]; other site 395495005428 G-X-G motif; other site 395495005429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495005430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005431 active site 395495005432 phosphorylation site [posttranslational modification] 395495005433 intermolecular recognition site; other site 395495005434 dimerization interface [polypeptide binding]; other site 395495005435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495005436 DNA binding site [nucleotide binding] 395495005437 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 395495005438 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 395495005439 NAD binding site [chemical binding]; other site 395495005440 homotetramer interface [polypeptide binding]; other site 395495005441 homodimer interface [polypeptide binding]; other site 395495005442 substrate binding site [chemical binding]; other site 395495005443 active site 395495005444 ribosome maturation protein RimP; Reviewed; Region: PRK00092 395495005445 Sm and related proteins; Region: Sm_like; cl00259 395495005446 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 395495005447 putative oligomer interface [polypeptide binding]; other site 395495005448 putative RNA binding site [nucleotide binding]; other site 395495005449 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 395495005450 NusA N-terminal domain; Region: NusA_N; pfam08529 395495005451 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 395495005452 RNA binding site [nucleotide binding]; other site 395495005453 homodimer interface [polypeptide binding]; other site 395495005454 NusA-like KH domain; Region: KH_5; pfam13184 395495005455 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 395495005456 G-X-X-G motif; other site 395495005457 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 395495005458 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 395495005459 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 395495005460 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 395495005461 translation initiation factor IF-2; Region: IF-2; TIGR00487 395495005462 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 395495005463 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 395495005464 G1 box; other site 395495005465 putative GEF interaction site [polypeptide binding]; other site 395495005466 GTP/Mg2+ binding site [chemical binding]; other site 395495005467 Switch I region; other site 395495005468 G2 box; other site 395495005469 G3 box; other site 395495005470 Switch II region; other site 395495005471 G4 box; other site 395495005472 G5 box; other site 395495005473 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 395495005474 Translation-initiation factor 2; Region: IF-2; pfam11987 395495005475 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 395495005476 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 395495005477 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 395495005478 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 395495005479 RNA binding site [nucleotide binding]; other site 395495005480 active site 395495005481 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 395495005482 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 395495005483 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 395495005484 G1 box; other site 395495005485 putative GEF interaction site [polypeptide binding]; other site 395495005486 GTP/Mg2+ binding site [chemical binding]; other site 395495005487 Switch I region; other site 395495005488 G2 box; other site 395495005489 G3 box; other site 395495005490 Switch II region; other site 395495005491 G4 box; other site 395495005492 G5 box; other site 395495005493 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 395495005494 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 395495005495 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495005496 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 395495005497 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 395495005498 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 395495005499 Protein of unknown function, DUF547; Region: DUF547; pfam04784 395495005500 Uncharacterized conserved protein [Function unknown]; Region: COG0398 395495005501 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 395495005502 mercuric reductase; Validated; Region: PRK06370 395495005503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495005504 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395495005505 Permease; Region: Permease; pfam02405 395495005506 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 395495005507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495005508 Walker A/P-loop; other site 395495005509 ATP binding site [chemical binding]; other site 395495005510 Q-loop/lid; other site 395495005511 ABC transporter signature motif; other site 395495005512 Walker B; other site 395495005513 D-loop; other site 395495005514 H-loop/switch region; other site 395495005515 Protein of unknown function (DUF330); Region: DUF330; pfam03886 395495005516 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395495005517 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 395495005518 active site 395495005519 nucleophile elbow; other site 395495005520 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 395495005521 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 395495005522 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 395495005523 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 395495005524 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 395495005525 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 395495005526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495005527 Walker A/P-loop; other site 395495005528 ATP binding site [chemical binding]; other site 395495005529 Q-loop/lid; other site 395495005530 ABC transporter signature motif; other site 395495005531 Walker B; other site 395495005532 D-loop; other site 395495005533 H-loop/switch region; other site 395495005534 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 395495005535 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495005536 substrate binding pocket [chemical binding]; other site 395495005537 membrane-bound complex binding site; other site 395495005538 hinge residues; other site 395495005539 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 395495005540 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 395495005541 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 395495005542 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 395495005543 putative glycosyltransferase, TIGR04348 family; Region: TIGR04348 395495005544 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495005545 selenophosphate synthetase; Provisional; Region: PRK00943 395495005546 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 395495005547 dimerization interface [polypeptide binding]; other site 395495005548 putative ATP binding site [chemical binding]; other site 395495005549 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 395495005550 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395495005551 FMN binding site [chemical binding]; other site 395495005552 active site 395495005553 catalytic residues [active] 395495005554 substrate binding site [chemical binding]; other site 395495005555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005557 metal binding site [ion binding]; metal-binding site 395495005558 active site 395495005559 I-site; other site 395495005560 Cache domain; Region: Cache_1; pfam02743 395495005561 PAS domain S-box; Region: sensory_box; TIGR00229 395495005562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005563 putative active site [active] 395495005564 heme pocket [chemical binding]; other site 395495005565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005567 metal binding site [ion binding]; metal-binding site 395495005568 active site 395495005569 I-site; other site 395495005570 EamA-like transporter family; Region: EamA; pfam00892 395495005571 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395495005572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005573 dimer interface [polypeptide binding]; other site 395495005574 conserved gate region; other site 395495005575 putative PBP binding loops; other site 395495005576 ABC-ATPase subunit interface; other site 395495005577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495005578 dimer interface [polypeptide binding]; other site 395495005579 conserved gate region; other site 395495005580 putative PBP binding loops; other site 395495005581 ABC-ATPase subunit interface; other site 395495005582 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 395495005583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495005584 Walker A/P-loop; other site 395495005585 ATP binding site [chemical binding]; other site 395495005586 Q-loop/lid; other site 395495005587 ABC transporter signature motif; other site 395495005588 Walker B; other site 395495005589 D-loop; other site 395495005590 H-loop/switch region; other site 395495005591 TOBE domain; Region: TOBE_2; pfam08402 395495005592 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 395495005593 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 395495005594 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 395495005595 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 395495005596 NAD(P) binding site [chemical binding]; other site 395495005597 catalytic residues [active] 395495005598 putative aminotransferase; Validated; Region: PRK07480 395495005599 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495005600 inhibitor-cofactor binding pocket; inhibition site 395495005601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495005602 catalytic residue [active] 395495005603 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 395495005604 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395495005605 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395495005606 Peptidase C26; Region: Peptidase_C26; pfam07722 395495005607 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 395495005608 catalytic triad [active] 395495005609 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 395495005610 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 395495005611 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 395495005612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495005613 inhibitor-cofactor binding pocket; inhibition site 395495005614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495005615 catalytic residue [active] 395495005616 Hemerythrin-like domain; Region: Hr-like; cd12108 395495005617 Fe binding site [ion binding]; other site 395495005618 isocitrate lyase; Provisional; Region: PRK15063 395495005619 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 395495005620 tetramer interface [polypeptide binding]; other site 395495005621 active site 395495005622 Mg2+/Mn2+ binding site [ion binding]; other site 395495005623 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 395495005624 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 395495005625 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 395495005626 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 395495005627 active site 395495005628 dimer interface [polypeptide binding]; other site 395495005629 motif 1; other site 395495005630 motif 2; other site 395495005631 motif 3; other site 395495005632 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 395495005633 anticodon binding site; other site 395495005634 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 395495005635 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 395495005636 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 395495005637 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 395495005638 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 395495005639 23S rRNA binding site [nucleotide binding]; other site 395495005640 L21 binding site [polypeptide binding]; other site 395495005641 L13 binding site [polypeptide binding]; other site 395495005642 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 395495005643 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 395495005644 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 395495005645 dimer interface [polypeptide binding]; other site 395495005646 motif 1; other site 395495005647 active site 395495005648 motif 2; other site 395495005649 motif 3; other site 395495005650 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 395495005651 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 395495005652 putative tRNA-binding site [nucleotide binding]; other site 395495005653 B3/4 domain; Region: B3_4; pfam03483 395495005654 tRNA synthetase B5 domain; Region: B5; smart00874 395495005655 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 395495005656 dimer interface [polypeptide binding]; other site 395495005657 motif 1; other site 395495005658 motif 3; other site 395495005659 motif 2; other site 395495005660 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 395495005661 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395495005662 IHF - DNA interface [nucleotide binding]; other site 395495005663 IHF dimer interface [polypeptide binding]; other site 395495005664 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 395495005665 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395495005666 DNA binding residues [nucleotide binding] 395495005667 TPR repeat; Region: TPR_11; pfam13414 395495005668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495005669 binding surface 395495005670 TPR motif; other site 395495005671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495005672 binding surface 395495005673 TPR motif; other site 395495005674 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 395495005675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495005676 binding surface 395495005677 TPR motif; other site 395495005678 TPR repeat; Region: TPR_11; pfam13414 395495005679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495005680 binding surface 395495005681 TPR motif; other site 395495005682 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495005683 Methyltransferase domain; Region: Methyltransf_24; pfam13578 395495005684 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 395495005685 putative active site [active] 395495005686 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 395495005687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495005688 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 395495005689 Walker A/P-loop; other site 395495005690 ATP binding site [chemical binding]; other site 395495005691 Q-loop/lid; other site 395495005692 ABC transporter signature motif; other site 395495005693 Walker B; other site 395495005694 D-loop; other site 395495005695 H-loop/switch region; other site 395495005696 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395495005697 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495005698 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495005699 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395495005700 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495005701 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 395495005702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495005703 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 395495005704 Walker A/P-loop; other site 395495005705 ATP binding site [chemical binding]; other site 395495005706 Q-loop/lid; other site 395495005707 ABC transporter signature motif; other site 395495005708 Walker B; other site 395495005709 D-loop; other site 395495005710 H-loop/switch region; other site 395495005711 Outer membrane efflux protein; Region: OEP; pfam02321 395495005712 Outer membrane efflux protein; Region: OEP; pfam02321 395495005713 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 395495005714 AMP binding site [chemical binding]; other site 395495005715 metal binding site [ion binding]; metal-binding site 395495005716 active site 395495005717 aminopeptidase N; Provisional; Region: pepN; PRK14015 395495005718 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 395495005719 Zn binding site [ion binding]; other site 395495005720 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 395495005721 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395495005722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495005723 motif II; other site 395495005724 peptide chain release factor 2; Provisional; Region: PRK08787 395495005725 This domain is found in peptide chain release factors; Region: PCRF; smart00937 395495005726 RF-1 domain; Region: RF-1; pfam00472 395495005727 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 395495005728 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395495005729 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 395495005730 catalytic site [active] 395495005731 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395495005732 CheW-like domain; Region: CheW; pfam01584 395495005733 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 395495005734 PAS domain; Region: PAS_9; pfam13426 395495005735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005736 PAS domain; Region: PAS_9; pfam13426 395495005737 putative active site [active] 395495005738 heme pocket [chemical binding]; other site 395495005739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005740 PAS domain; Region: PAS_9; pfam13426 395495005741 putative active site [active] 395495005742 heme pocket [chemical binding]; other site 395495005743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005744 PAS domain; Region: PAS_9; pfam13426 395495005745 putative active site [active] 395495005746 heme pocket [chemical binding]; other site 395495005747 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495005748 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495005749 dimer interface [polypeptide binding]; other site 395495005750 putative CheW interface [polypeptide binding]; other site 395495005751 Biofilm formation and stress response factor; Region: BsmA; pfam10014 395495005752 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 395495005753 active site 395495005754 putative substrate binding region [chemical binding]; other site 395495005755 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 395495005756 active site 395495005757 catalytic triad [active] 395495005758 Predicted transcriptional regulator [Transcription]; Region: COG2378 395495005759 HTH domain; Region: HTH_11; pfam08279 395495005760 WYL domain; Region: WYL; pfam13280 395495005761 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 395495005762 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 395495005763 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 395495005764 Family description; Region: UvrD_C_2; pfam13538 395495005765 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 395495005766 AAA domain; Region: AAA_30; pfam13604 395495005767 Family description; Region: UvrD_C_2; pfam13538 395495005768 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495005769 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 395495005770 putative ligand binding site [chemical binding]; other site 395495005771 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 395495005772 DctM-like transporters; Region: DctM; pfam06808 395495005773 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 395495005774 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 395495005775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495005776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495005777 active site 395495005778 phosphorylation site [posttranslational modification] 395495005779 intermolecular recognition site; other site 395495005780 dimerization interface [polypeptide binding]; other site 395495005781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495005782 DNA binding residues [nucleotide binding] 395495005783 dimerization interface [polypeptide binding]; other site 395495005784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 395495005785 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 395495005786 Histidine kinase; Region: HisKA_3; pfam07730 395495005787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495005788 ATP binding site [chemical binding]; other site 395495005789 Mg2+ binding site [ion binding]; other site 395495005790 G-X-G motif; other site 395495005791 Putative phosphatase (DUF442); Region: DUF442; cl17385 395495005792 Yqey-like protein; Region: YqeY; pfam09424 395495005793 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 395495005794 HI0933-like protein; Region: HI0933_like; pfam03486 395495005795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495005796 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395495005797 substrate binding pocket [chemical binding]; other site 395495005798 membrane-bound complex binding site; other site 395495005799 hinge residues; other site 395495005800 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495005801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495005802 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495005803 Walker A motif; other site 395495005804 ATP binding site [chemical binding]; other site 395495005805 Walker B motif; other site 395495005806 arginine finger; other site 395495005807 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495005808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395495005809 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 395495005810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495005811 Walker A/P-loop; other site 395495005812 ATP binding site [chemical binding]; other site 395495005813 Q-loop/lid; other site 395495005814 ABC transporter signature motif; other site 395495005815 Walker B; other site 395495005816 D-loop; other site 395495005817 H-loop/switch region; other site 395495005818 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 395495005819 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495005820 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495005821 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495005822 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 395495005823 ligand binding site [chemical binding]; other site 395495005824 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395495005825 ABC-2 type transporter; Region: ABC2_membrane; cl17235 395495005826 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 395495005827 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 395495005828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 395495005829 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 395495005830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495005831 active site 395495005832 DNA binding site [nucleotide binding] 395495005833 Int/Topo IB signature motif; other site 395495005834 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 395495005835 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 395495005836 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 395495005837 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395495005838 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395495005839 structural tetrad; other site 395495005840 FOG: WD40 repeat [General function prediction only]; Region: COG2319 395495005841 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 395495005842 structural tetrad; other site 395495005843 TIR domain; Region: TIR_2; pfam13676 395495005844 Peptidase family M48; Region: Peptidase_M48; pfam01435 395495005845 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 395495005846 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 395495005847 dimer interface [polypeptide binding]; other site 395495005848 Trp docking motif [polypeptide binding]; other site 395495005849 active site 395495005850 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 395495005851 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 395495005852 dimer interface [polypeptide binding]; other site 395495005853 putative functional site; other site 395495005854 putative MPT binding site; other site 395495005855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 395495005856 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 395495005857 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395495005858 Walker A/P-loop; other site 395495005859 ATP binding site [chemical binding]; other site 395495005860 Q-loop/lid; other site 395495005861 ABC transporter signature motif; other site 395495005862 Walker B; other site 395495005863 D-loop; other site 395495005864 H-loop/switch region; other site 395495005865 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 395495005866 PBP superfamily domain; Region: PBP_like_2; pfam12849 395495005867 Ferredoxin [Energy production and conversion]; Region: COG1146 395495005868 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 395495005869 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 395495005870 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 395495005871 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 395495005872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 395495005873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495005874 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495005875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495005876 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 395495005877 thiS-thiF/thiG interaction site; other site 395495005878 GYD domain; Region: GYD; pfam08734 395495005879 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 395495005880 PBP superfamily domain; Region: PBP_like; pfam12727 395495005881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495005882 dimerization interface [polypeptide binding]; other site 395495005883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495005884 PAS domain; Region: PAS_9; pfam13426 395495005885 putative active site [active] 395495005886 heme pocket [chemical binding]; other site 395495005887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005889 metal binding site [ion binding]; metal-binding site 395495005890 active site 395495005891 I-site; other site 395495005892 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495005893 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395495005894 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 395495005895 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 395495005896 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 395495005897 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395495005898 N-terminal plug; other site 395495005899 ligand-binding site [chemical binding]; other site 395495005900 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 395495005901 MarR family; Region: MarR; pfam01047 395495005902 Sensors of blue-light using FAD; Region: BLUF; pfam04940 395495005903 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 395495005904 active site 395495005905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495005906 putative substrate translocation pore; other site 395495005907 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 395495005908 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 395495005909 metal-binding site [ion binding] 395495005910 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395495005911 metal-binding site [ion binding] 395495005912 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395495005913 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395495005914 metal-binding site [ion binding] 395495005915 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395495005916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495005917 motif II; other site 395495005918 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395495005919 CoenzymeA binding site [chemical binding]; other site 395495005920 subunit interaction site [polypeptide binding]; other site 395495005921 PHB binding site; other site 395495005922 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 395495005923 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 395495005924 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495005925 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 395495005926 intracellular septation protein A; Reviewed; Region: PRK00259 395495005927 methionine sulfoxide reductase B; Provisional; Region: PRK00222 395495005928 SelR domain; Region: SelR; pfam01641 395495005929 Uncharacterized conserved protein [Function unknown]; Region: COG0397 395495005930 hypothetical protein; Validated; Region: PRK00029 395495005931 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 395495005932 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 395495005933 dimer interface [polypeptide binding]; other site 395495005934 acyl-activating enzyme (AAE) consensus motif; other site 395495005935 putative active site [active] 395495005936 AMP binding site [chemical binding]; other site 395495005937 putative CoA binding site [chemical binding]; other site 395495005938 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 395495005939 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395495005940 active site 395495005941 putative acetyltransferase; Provisional; Region: PRK03624 395495005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495005943 Coenzyme A binding pocket [chemical binding]; other site 395495005944 Predicted membrane protein [Function unknown]; Region: COG2860 395495005945 UPF0126 domain; Region: UPF0126; pfam03458 395495005946 UPF0126 domain; Region: UPF0126; pfam03458 395495005947 Transglycosylase SLT domain; Region: SLT_2; pfam13406 395495005948 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 395495005949 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495005950 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495005951 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395495005952 putative protease; Provisional; Region: PRK15452 395495005953 Peptidase family U32; Region: Peptidase_U32; pfam01136 395495005954 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495005955 TM-ABC transporter signature motif; other site 395495005956 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495005957 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495005958 TM-ABC transporter signature motif; other site 395495005959 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495005960 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495005961 Walker A/P-loop; other site 395495005962 ATP binding site [chemical binding]; other site 395495005963 Q-loop/lid; other site 395495005964 ABC transporter signature motif; other site 395495005965 Walker B; other site 395495005966 D-loop; other site 395495005967 H-loop/switch region; other site 395495005968 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495005969 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495005970 Walker A/P-loop; other site 395495005971 ATP binding site [chemical binding]; other site 395495005972 Q-loop/lid; other site 395495005973 ABC transporter signature motif; other site 395495005974 Walker B; other site 395495005975 D-loop; other site 395495005976 H-loop/switch region; other site 395495005977 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395495005978 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395495005979 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395495005980 CoenzymeA binding site [chemical binding]; other site 395495005981 subunit interaction site [polypeptide binding]; other site 395495005982 PHB binding site; other site 395495005983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 395495005984 PAS domain; Region: PAS_9; pfam13426 395495005985 PAS domain; Region: PAS_9; pfam13426 395495005986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495005987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495005988 metal binding site [ion binding]; metal-binding site 395495005989 active site 395495005990 I-site; other site 395495005991 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 395495005992 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 395495005993 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 395495005994 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 395495005995 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 395495005996 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 395495005997 RNA binding site [nucleotide binding]; other site 395495005998 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 395495005999 active site 395495006000 putative metal dependent hydrolase; Provisional; Region: PRK11598 395495006001 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 395495006002 Sulfatase; Region: Sulfatase; pfam00884 395495006003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495006004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495006005 active site 395495006006 phosphorylation site [posttranslational modification] 395495006007 intermolecular recognition site; other site 395495006008 dimerization interface [polypeptide binding]; other site 395495006009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495006010 DNA binding site [nucleotide binding] 395495006011 sensor protein QseC; Provisional; Region: PRK10337 395495006012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495006013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 395495006014 dimer interface [polypeptide binding]; other site 395495006015 phosphorylation site [posttranslational modification] 395495006016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 395495006017 ATP binding site [chemical binding]; other site 395495006018 G-X-G motif; other site 395495006019 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 395495006020 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 395495006021 Patatin-like phospholipase; Region: Patatin; pfam01734 395495006022 active site 395495006023 nucleophile elbow; other site 395495006024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 395495006025 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 395495006026 substrate binding pocket [chemical binding]; other site 395495006027 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395495006028 active site 395495006029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 395495006030 NRDE protein; Region: NRDE; cl01315 395495006031 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 395495006032 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 395495006033 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 395495006034 YceG-like family; Region: YceG; pfam02618 395495006035 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 395495006036 dimerization interface [polypeptide binding]; other site 395495006037 thymidylate kinase; Validated; Region: tmk; PRK00698 395495006038 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 395495006039 TMP-binding site; other site 395495006040 ATP-binding site [chemical binding]; other site 395495006041 DNA polymerase III subunit delta'; Validated; Region: PRK06964 395495006042 DNA polymerase III subunit delta'; Validated; Region: PRK08485 395495006043 PilZ domain; Region: PilZ; cl01260 395495006044 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 395495006045 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 395495006046 active site 395495006047 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 395495006048 active site 395495006049 catalytic residues [active] 395495006050 metal binding site [ion binding]; metal-binding site 395495006051 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 395495006052 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 395495006053 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 395495006054 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 395495006055 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 395495006056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395495006057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495006058 catalytic residue [active] 395495006059 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 395495006060 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 395495006061 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 395495006062 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 395495006063 active site 395495006064 catalytic site [active] 395495006065 phosphoglucomutase; Region: PLN02307 395495006066 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 395495006067 active site 395495006068 substrate binding site [chemical binding]; other site 395495006069 metal binding site [ion binding]; metal-binding site 395495006070 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 395495006071 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 395495006072 ligand binding site; other site 395495006073 oligomer interface; other site 395495006074 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 395495006075 dimer interface [polypeptide binding]; other site 395495006076 N-terminal domain interface [polypeptide binding]; other site 395495006077 sulfate 1 binding site; other site 395495006078 glycogen synthase; Provisional; Region: glgA; PRK00654 395495006079 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 395495006080 ADP-binding pocket [chemical binding]; other site 395495006081 homodimer interface [polypeptide binding]; other site 395495006082 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 395495006083 homodimer interface [polypeptide binding]; other site 395495006084 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 395495006085 active site pocket [active] 395495006086 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 395495006087 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395495006088 metal ion-dependent adhesion site (MIDAS); other site 395495006089 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495006090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495006091 Walker A motif; other site 395495006092 ATP binding site [chemical binding]; other site 395495006093 Walker B motif; other site 395495006094 arginine finger; other site 395495006095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495006096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495006097 dimerization interface [polypeptide binding]; other site 395495006098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495006099 dimer interface [polypeptide binding]; other site 395495006100 phosphorylation site [posttranslational modification] 395495006101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495006102 ATP binding site [chemical binding]; other site 395495006103 Mg2+ binding site [ion binding]; other site 395495006104 G-X-G motif; other site 395495006105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495006106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495006107 active site 395495006108 phosphorylation site [posttranslational modification] 395495006109 intermolecular recognition site; other site 395495006110 dimerization interface [polypeptide binding]; other site 395495006111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495006112 DNA binding site [nucleotide binding] 395495006113 Uncharacterized conserved protein [Function unknown]; Region: COG2968 395495006114 Protein of unknown function (DUF541); Region: SIMPL; cl01077 395495006115 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 395495006116 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 395495006117 NAD binding site [chemical binding]; other site 395495006118 homotetramer interface [polypeptide binding]; other site 395495006119 homodimer interface [polypeptide binding]; other site 395495006120 substrate binding site [chemical binding]; other site 395495006121 active site 395495006122 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395495006123 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 395495006124 HD domain; Region: HD_4; pfam13328 395495006125 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 395495006126 synthetase active site [active] 395495006127 NTP binding site [chemical binding]; other site 395495006128 metal binding site [ion binding]; metal-binding site 395495006129 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 395495006130 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 395495006131 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 395495006132 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 395495006133 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 395495006134 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 395495006135 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 395495006136 active site 395495006137 catalytic triad [active] 395495006138 oxyanion hole [active] 395495006139 switch loop; other site 395495006140 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 395495006141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495006142 Walker A/P-loop; other site 395495006143 ATP binding site [chemical binding]; other site 395495006144 Q-loop/lid; other site 395495006145 ABC transporter signature motif; other site 395495006146 Walker B; other site 395495006147 D-loop; other site 395495006148 H-loop/switch region; other site 395495006149 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 395495006150 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 395495006151 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 395495006152 NAD-dependent deacetylase; Provisional; Region: PRK00481 395495006153 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 395495006154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495006155 active site 395495006156 Protein of unknown function DUF111; Region: DUF111; cl03398 395495006157 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395495006158 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 395495006159 dimerization interface [polypeptide binding]; other site 395495006160 NAD binding site [chemical binding]; other site 395495006161 ligand binding site [chemical binding]; other site 395495006162 catalytic site [active] 395495006163 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 395495006164 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 395495006165 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 395495006166 active site 395495006167 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 395495006168 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 395495006169 dimerization interface [polypeptide binding]; other site 395495006170 active site 395495006171 PilZ domain; Region: PilZ; pfam07238 395495006172 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 395495006173 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 395495006174 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 395495006175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495006176 RNA binding surface [nucleotide binding]; other site 395495006177 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 395495006178 active site 395495006179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495006180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495006181 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 395495006182 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 395495006183 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 395495006184 dimerization interface [polypeptide binding]; other site 395495006185 ATP binding site [chemical binding]; other site 395495006186 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 395495006187 dimerization interface [polypeptide binding]; other site 395495006188 ATP binding site [chemical binding]; other site 395495006189 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 395495006190 putative active site [active] 395495006191 catalytic triad [active] 395495006192 Predicted dehydrogenase [General function prediction only]; Region: COG0579 395495006193 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395495006194 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 395495006195 active site 395495006196 PII uridylyl-transferase; Provisional; Region: PRK03059 395495006197 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395495006198 metal binding triad; other site 395495006199 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 395495006200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495006201 Zn2+ binding site [ion binding]; other site 395495006202 Mg2+ binding site [ion binding]; other site 395495006203 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 395495006204 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 395495006205 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 395495006206 TRAM domain; Region: TRAM; pfam01938 395495006207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495006208 S-adenosylmethionine binding site [chemical binding]; other site 395495006209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395495006210 Peptidase family M23; Region: Peptidase_M23; pfam01551 395495006211 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 395495006212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495006213 S-adenosylmethionine binding site [chemical binding]; other site 395495006214 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 395495006215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495006216 Response regulator receiver domain; Region: Response_reg; pfam00072 395495006217 active site 395495006218 phosphorylation site [posttranslational modification] 395495006219 intermolecular recognition site; other site 395495006220 dimerization interface [polypeptide binding]; other site 395495006221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495006222 DNA binding residues [nucleotide binding] 395495006223 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495006224 Ligand Binding Site [chemical binding]; other site 395495006225 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 395495006226 ABC-2 type transporter; Region: ABC2_membrane; cl17235 395495006227 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 395495006228 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 395495006229 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 395495006230 Walker A/P-loop; other site 395495006231 ATP binding site [chemical binding]; other site 395495006232 Q-loop/lid; other site 395495006233 ABC transporter signature motif; other site 395495006234 Walker B; other site 395495006235 D-loop; other site 395495006236 H-loop/switch region; other site 395495006237 periplasmic folding chaperone; Provisional; Region: PRK10788 395495006238 SurA N-terminal domain; Region: SurA_N_3; cl07813 395495006239 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495006240 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395495006241 IHF dimer interface [polypeptide binding]; other site 395495006242 IHF - DNA interface [nucleotide binding]; other site 395495006243 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495006244 EamA-like transporter family; Region: EamA; pfam00892 395495006245 EamA-like transporter family; Region: EamA; pfam00892 395495006246 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 395495006247 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 395495006248 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 395495006249 GIY-YIG motif/motif A; other site 395495006250 active site 395495006251 catalytic site [active] 395495006252 putative DNA binding site [nucleotide binding]; other site 395495006253 metal binding site [ion binding]; metal-binding site 395495006254 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 395495006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 395495006256 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 395495006257 elongation factor P; Validated; Region: PRK00529 395495006258 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 395495006259 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 395495006260 RNA binding site [nucleotide binding]; other site 395495006261 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 395495006262 RNA binding site [nucleotide binding]; other site 395495006263 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495006264 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495006265 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495006266 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 395495006267 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 395495006268 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 395495006269 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 395495006270 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 395495006271 putative ATP binding site [chemical binding]; other site 395495006272 putative substrate interface [chemical binding]; other site 395495006273 Predicted transporter component [General function prediction only]; Region: COG2391 395495006274 Sulphur transport; Region: Sulf_transp; pfam04143 395495006275 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 395495006276 Tetratricopeptide repeat; Region: TPR_6; pfam13174 395495006277 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495006278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495006279 ligand binding site [chemical binding]; other site 395495006280 translocation protein TolB; Provisional; Region: tolB; PRK02889 395495006281 TolB amino-terminal domain; Region: TolB_N; pfam04052 395495006282 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495006283 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495006284 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495006285 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 395495006286 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 395495006287 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 395495006288 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 395495006289 ribonuclease G; Provisional; Region: PRK11712 395495006290 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 395495006291 homodimer interface [polypeptide binding]; other site 395495006292 oligonucleotide binding site [chemical binding]; other site 395495006293 Maf-like protein; Region: Maf; pfam02545 395495006294 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 395495006295 active site 395495006296 dimer interface [polypeptide binding]; other site 395495006297 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 395495006298 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 395495006299 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 395495006300 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 395495006301 active site 395495006302 (T/H)XGH motif; other site 395495006303 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 395495006304 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 395495006305 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 395495006306 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 395495006307 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 395495006308 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 395495006309 hypothetical protein; Validated; Region: PRK00110 395495006310 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 395495006311 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 395495006312 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 395495006313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495006314 active site 395495006315 HIGH motif; other site 395495006316 nucleotide binding site [chemical binding]; other site 395495006317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495006318 active site 395495006319 KMSKS motif; other site 395495006320 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 395495006321 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 395495006322 dimer interface [polypeptide binding]; other site 395495006323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495006324 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 395495006325 AAA ATPase domain; Region: AAA_15; pfam13175 395495006326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495006327 Walker A/P-loop; other site 395495006328 ATP binding site [chemical binding]; other site 395495006329 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 395495006330 putative active site [active] 395495006331 putative metal-binding site [ion binding]; other site 395495006332 putative transposase OrfB; Reviewed; Region: PHA02517 395495006333 Integrase core domain; Region: rve; pfam00665 395495006334 Integrase core domain; Region: rve_3; pfam13683 395495006335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495006336 Transposase; Region: HTH_Tnp_1; pfam01527 395495006337 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 395495006338 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 395495006339 Predicted ATPase [General function prediction only]; Region: COG4637 395495006340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495006341 Walker A/P-loop; other site 395495006342 ATP binding site [chemical binding]; other site 395495006343 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395495006344 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495006345 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495006346 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 395495006347 RNA/DNA hybrid binding site [nucleotide binding]; other site 395495006348 active site 395495006349 Methyltransferase domain; Region: Methyltransf_11; pfam08241 395495006350 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 395495006351 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 395495006352 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495006353 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495006354 catalytic residue [active] 395495006355 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 395495006356 recombination protein RecR; Reviewed; Region: recR; PRK00076 395495006357 RecR protein; Region: RecR; pfam02132 395495006358 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 395495006359 putative active site [active] 395495006360 putative metal-binding site [ion binding]; other site 395495006361 tetramer interface [polypeptide binding]; other site 395495006362 hypothetical protein; Validated; Region: PRK00153 395495006363 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 395495006364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495006365 Walker A motif; other site 395495006366 ATP binding site [chemical binding]; other site 395495006367 Walker B motif; other site 395495006368 arginine finger; other site 395495006369 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 395495006370 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 395495006371 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 395495006372 ATP binding site [chemical binding]; other site 395495006373 dimerization interface [polypeptide binding]; other site 395495006374 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 395495006375 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 395495006376 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 395495006377 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 395495006378 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 395495006379 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395495006380 classical (c) SDRs; Region: SDR_c; cd05233 395495006381 NAD(P) binding site [chemical binding]; other site 395495006382 active site 395495006383 Gram-negative porin; Region: Porin_4; pfam13609 395495006384 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 395495006385 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 395495006386 PAS domain; Region: PAS_8; pfam13188 395495006387 PAS domain; Region: PAS_9; pfam13426 395495006388 putative active site [active] 395495006389 heme pocket [chemical binding]; other site 395495006390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495006391 DNA binding residues [nucleotide binding] 395495006392 dimerization interface [polypeptide binding]; other site 395495006393 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 395495006394 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 395495006395 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495006396 catalytic loop [active] 395495006397 iron binding site [ion binding]; other site 395495006398 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395495006399 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 395495006400 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495006401 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 395495006402 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495006403 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495006404 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 395495006405 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 395495006406 dimerization interface [polypeptide binding]; other site 395495006407 ligand binding site [chemical binding]; other site 395495006408 NADP binding site [chemical binding]; other site 395495006409 catalytic site [active] 395495006410 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395495006411 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 395495006412 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 395495006413 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 395495006414 putative active site [active] 395495006415 Zn binding site [ion binding]; other site 395495006416 Phasin protein; Region: Phasin_2; pfam09361 395495006417 Protein of unknown function (DUF461); Region: DUF461; pfam04314 395495006418 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495006419 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495006420 Cu(I) binding site [ion binding]; other site 395495006421 Protein of unknown function (DUF461); Region: DUF461; pfam04314 395495006422 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495006423 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 395495006424 ligand binding site [chemical binding]; other site 395495006425 Protein of unknown function, DUF399; Region: DUF399; pfam04187 395495006426 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 395495006427 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 395495006428 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 395495006429 motif 1; other site 395495006430 active site 395495006431 motif 2; other site 395495006432 motif 3; other site 395495006433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 395495006434 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 395495006435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495006436 inhibitor-cofactor binding pocket; inhibition site 395495006437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495006438 catalytic residue [active] 395495006439 succinic semialdehyde dehydrogenase; Region: PLN02278 395495006440 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 395495006441 tetramerization interface [polypeptide binding]; other site 395495006442 NAD(P) binding site [chemical binding]; other site 395495006443 catalytic residues [active] 395495006444 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495006445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495006446 metal binding site [ion binding]; metal-binding site 395495006447 active site 395495006448 I-site; other site 395495006449 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 395495006450 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 395495006451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495006452 ATP binding site [chemical binding]; other site 395495006453 putative Mg++ binding site [ion binding]; other site 395495006454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495006455 nucleotide binding region [chemical binding]; other site 395495006456 ATP-binding site [chemical binding]; other site 395495006457 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 395495006458 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395495006459 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395495006460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495006461 motif II; other site 395495006462 HDOD domain; Region: HDOD; pfam08668 395495006463 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 395495006464 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 395495006465 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 395495006466 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 395495006467 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 395495006468 DsbD alpha interface [polypeptide binding]; other site 395495006469 catalytic residues [active] 395495006470 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395495006471 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495006472 catalytic residues [active] 395495006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495006474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495006475 putative substrate translocation pore; other site 395495006476 quinolinate synthetase; Provisional; Region: PRK09375 395495006477 Late competence development protein ComFB; Region: ComFB; pfam10719 395495006478 L-aspartate oxidase; Provisional; Region: PRK09077 395495006479 L-aspartate oxidase; Provisional; Region: PRK06175 395495006480 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395495006481 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 395495006482 Clp amino terminal domain; Region: Clp_N; pfam02861 395495006483 Clp amino terminal domain; Region: Clp_N; pfam02861 395495006484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495006485 Walker A motif; other site 395495006486 ATP binding site [chemical binding]; other site 395495006487 Walker B motif; other site 395495006488 arginine finger; other site 395495006489 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 395495006490 primary dimer interface [polypeptide binding]; other site 395495006491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495006492 Walker A motif; other site 395495006493 ATP binding site [chemical binding]; other site 395495006494 Walker B motif; other site 395495006495 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 395495006496 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 395495006497 MoaE homodimer interface [polypeptide binding]; other site 395495006498 MoaD interaction [polypeptide binding]; other site 395495006499 active site residues [active] 395495006500 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 395495006501 MoaE interaction surface [polypeptide binding]; other site 395495006502 MoeB interaction surface [polypeptide binding]; other site 395495006503 thiocarboxylated glycine; other site 395495006504 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 395495006505 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 395495006506 dimer interface [polypeptide binding]; other site 395495006507 putative functional site; other site 395495006508 putative MPT binding site; other site 395495006509 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 395495006510 Walker A motif; other site 395495006511 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 395495006512 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 395495006513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495006514 catalytic residue [active] 395495006515 homoserine dehydrogenase; Provisional; Region: PRK06349 395495006516 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 395495006517 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 395495006518 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 395495006519 aminotransferase AlaT; Validated; Region: PRK09265 395495006520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495006521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495006522 homodimer interface [polypeptide binding]; other site 395495006523 catalytic residue [active] 395495006524 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 395495006525 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 395495006526 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 395495006527 catalytic triad [active] 395495006528 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 395495006529 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 395495006530 putative active site [active] 395495006531 PhoH-like protein; Region: PhoH; pfam02562 395495006532 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 395495006533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395495006534 Walker A/P-loop; other site 395495006535 ATP binding site [chemical binding]; other site 395495006536 Q-loop/lid; other site 395495006537 ABC transporter signature motif; other site 395495006538 Walker B; other site 395495006539 D-loop; other site 395495006540 H-loop/switch region; other site 395495006541 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 395495006542 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 395495006543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 395495006544 Walker A/P-loop; other site 395495006545 ATP binding site [chemical binding]; other site 395495006546 Q-loop/lid; other site 395495006547 ABC transporter signature motif; other site 395495006548 Walker B; other site 395495006549 D-loop; other site 395495006550 H-loop/switch region; other site 395495006551 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 395495006552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 395495006553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495006554 dimer interface [polypeptide binding]; other site 395495006555 conserved gate region; other site 395495006556 putative PBP binding loops; other site 395495006557 ABC-ATPase subunit interface; other site 395495006558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 395495006559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495006560 dimer interface [polypeptide binding]; other site 395495006561 conserved gate region; other site 395495006562 putative PBP binding loops; other site 395495006563 ABC-ATPase subunit interface; other site 395495006564 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 395495006565 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 395495006566 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 395495006567 dimer interface [polypeptide binding]; other site 395495006568 catalytic triad [active] 395495006569 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 395495006570 nucleoside/Zn binding site; other site 395495006571 dimer interface [polypeptide binding]; other site 395495006572 catalytic motif [active] 395495006573 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 395495006574 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 395495006575 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395495006576 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395495006577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495006578 motif II; other site 395495006579 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395495006580 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495006581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395495006582 putative DNA binding site [nucleotide binding]; other site 395495006583 putative Zn2+ binding site [ion binding]; other site 395495006584 AsnC family; Region: AsnC_trans_reg; pfam01037 395495006585 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 395495006586 zinc binding site [ion binding]; other site 395495006587 putative ligand binding site [chemical binding]; other site 395495006588 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 395495006589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495006590 TM-ABC transporter signature motif; other site 395495006591 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 395495006592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495006593 Walker A/P-loop; other site 395495006594 ATP binding site [chemical binding]; other site 395495006595 Q-loop/lid; other site 395495006596 ABC transporter signature motif; other site 395495006597 Walker B; other site 395495006598 D-loop; other site 395495006599 H-loop/switch region; other site 395495006600 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 395495006601 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 395495006602 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 395495006603 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 395495006604 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 395495006605 dimer interface [polypeptide binding]; other site 395495006606 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 395495006607 active site 395495006608 Fe binding site [ion binding]; other site 395495006609 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 395495006610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495006611 Zn binding site [ion binding]; other site 395495006612 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 395495006613 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 395495006614 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495006615 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 395495006616 aromatic arch; other site 395495006617 DCoH dimer interaction site [polypeptide binding]; other site 395495006618 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 395495006619 DCoH tetramer interaction site [polypeptide binding]; other site 395495006620 substrate binding site [chemical binding]; other site 395495006621 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 395495006622 cofactor binding site; other site 395495006623 metal binding site [ion binding]; metal-binding site 395495006624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495006625 short chain dehydrogenase; Provisional; Region: PRK12828 395495006626 NAD(P) binding site [chemical binding]; other site 395495006627 active site 395495006628 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 395495006629 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495006630 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495006631 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 395495006632 Outer membrane efflux protein; Region: OEP; pfam02321 395495006633 Outer membrane efflux protein; Region: OEP; pfam02321 395495006634 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 395495006635 RmuC family; Region: RmuC; pfam02646 395495006636 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 395495006637 Uncharacterized conserved protein [Function unknown]; Region: COG4121 395495006638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495006639 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 395495006640 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 395495006641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495006642 FeS/SAM binding site; other site 395495006643 cystathionine beta-lyase; Provisional; Region: PRK07050 395495006644 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395495006645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495006646 catalytic residue [active] 395495006647 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 395495006648 SmpB-tmRNA interface; other site 395495006649 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 395495006650 putative coenzyme Q binding site [chemical binding]; other site 395495006651 hypothetical protein; Validated; Region: PRK01777 395495006652 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 395495006653 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 395495006654 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395495006655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 395495006656 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 395495006657 active site 395495006658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495006659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495006660 putative substrate translocation pore; other site 395495006661 GMP synthase; Reviewed; Region: guaA; PRK00074 395495006662 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 395495006663 AMP/PPi binding site [chemical binding]; other site 395495006664 candidate oxyanion hole; other site 395495006665 catalytic triad [active] 395495006666 potential glutamine specificity residues [chemical binding]; other site 395495006667 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 395495006668 ATP Binding subdomain [chemical binding]; other site 395495006669 Ligand Binding sites [chemical binding]; other site 395495006670 Dimerization subdomain; other site 395495006671 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 395495006672 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 395495006673 putative Cl- selectivity filter; other site 395495006674 putative pore gating glutamate residue; other site 395495006675 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395495006676 active site 395495006677 Protein of unknown function, DUF480; Region: DUF480; pfam04337 395495006678 short chain dehydrogenase; Provisional; Region: PRK06949 395495006679 classical (c) SDRs; Region: SDR_c; cd05233 395495006680 NAD(P) binding site [chemical binding]; other site 395495006681 active site 395495006682 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 395495006683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495006684 PAS domain; Region: PAS_9; pfam13426 395495006685 putative active site [active] 395495006686 heme pocket [chemical binding]; other site 395495006687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495006688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495006689 metal binding site [ion binding]; metal-binding site 395495006690 active site 395495006691 I-site; other site 395495006692 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495006693 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 395495006694 hydroxyglutarate oxidase; Provisional; Region: PRK11728 395495006695 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 395495006696 cellulose synthase regulator protein; Provisional; Region: PRK11114 395495006697 endo-1,4-D-glucanase; Provisional; Region: PRK11097 395495006698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495006699 binding surface 395495006700 TPR motif; other site 395495006701 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 395495006702 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 395495006703 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 395495006704 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 395495006705 DXD motif; other site 395495006706 PilZ domain; Region: PilZ; pfam07238 395495006707 enoyl-CoA hydratase; Validated; Region: PRK08139 395495006708 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495006709 substrate binding site [chemical binding]; other site 395495006710 oxyanion hole (OAH) forming residues; other site 395495006711 trimer interface [polypeptide binding]; other site 395495006712 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 395495006713 acyl-CoA synthetase; Validated; Region: PRK08162 395495006714 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 395495006715 acyl-activating enzyme (AAE) consensus motif; other site 395495006716 putative active site [active] 395495006717 AMP binding site [chemical binding]; other site 395495006718 putative CoA binding site [chemical binding]; other site 395495006719 Transglycosylase SLT domain; Region: SLT_2; pfam13406 395495006720 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495006721 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495006722 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 395495006723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495006724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495006725 ABC transporter; Region: ABC_tran_2; pfam12848 395495006726 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495006727 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 395495006728 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 395495006729 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 395495006730 active site 395495006731 homotetramer interface [polypeptide binding]; other site 395495006732 homodimer interface [polypeptide binding]; other site 395495006733 LexA repressor; Validated; Region: PRK00215 395495006734 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 395495006735 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 395495006736 Catalytic site [active] 395495006737 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 395495006738 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 395495006739 active site residue [active] 395495006740 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 395495006741 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 395495006742 NAD(P) binding site [chemical binding]; other site 395495006743 homotetramer interface [polypeptide binding]; other site 395495006744 homodimer interface [polypeptide binding]; other site 395495006745 active site 395495006746 putative acyltransferase; Provisional; Region: PRK05790 395495006747 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495006748 dimer interface [polypeptide binding]; other site 395495006749 active site 395495006750 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 395495006751 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 395495006752 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 395495006753 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 395495006754 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 395495006755 maleylacetoacetate isomerase; Region: maiA; TIGR01262 395495006756 C-terminal domain interface [polypeptide binding]; other site 395495006757 GSH binding site (G-site) [chemical binding]; other site 395495006758 putative dimer interface [polypeptide binding]; other site 395495006759 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 395495006760 dimer interface [polypeptide binding]; other site 395495006761 N-terminal domain interface [polypeptide binding]; other site 395495006762 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 395495006763 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 395495006764 nudix motif; other site 395495006765 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 395495006766 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 395495006767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495006768 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 395495006769 Walker A/P-loop; other site 395495006770 ATP binding site [chemical binding]; other site 395495006771 Q-loop/lid; other site 395495006772 ABC transporter signature motif; other site 395495006773 Walker B; other site 395495006774 D-loop; other site 395495006775 H-loop/switch region; other site 395495006776 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395495006777 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395495006778 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495006779 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 395495006780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495006781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495006782 metal binding site [ion binding]; metal-binding site 395495006783 active site 395495006784 I-site; other site 395495006785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495006786 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 395495006787 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 395495006788 Arginase family; Region: Arginase; cd09989 395495006789 active site 395495006790 Mn binding site [ion binding]; other site 395495006791 oligomer interface [polypeptide binding]; other site 395495006792 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 395495006793 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 395495006794 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 395495006795 ATP binding site [chemical binding]; other site 395495006796 substrate interface [chemical binding]; other site 395495006797 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 395495006798 C-terminal peptidase (prc); Region: prc; TIGR00225 395495006799 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 395495006800 protein binding site [polypeptide binding]; other site 395495006801 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 395495006802 Catalytic dyad [active] 395495006803 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 395495006804 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 395495006805 Walker A/P-loop; other site 395495006806 ATP binding site [chemical binding]; other site 395495006807 Q-loop/lid; other site 395495006808 ABC transporter signature motif; other site 395495006809 Walker B; other site 395495006810 D-loop; other site 395495006811 H-loop/switch region; other site 395495006812 TOBE domain; Region: TOBE_2; pfam08402 395495006813 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 395495006814 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 395495006815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495006816 NAD(P) binding site [chemical binding]; other site 395495006817 catalytic residues [active] 395495006818 Protein of unknown function (DUF779); Region: DUF779; cl01432 395495006819 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 395495006820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 395495006821 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 395495006822 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 395495006823 ArsC family; Region: ArsC; pfam03960 395495006824 putative catalytic residues [active] 395495006825 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 395495006826 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 395495006827 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 395495006828 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 395495006829 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 395495006830 Lumazine binding domain; Region: Lum_binding; pfam00677 395495006831 Lumazine binding domain; Region: Lum_binding; pfam00677 395495006832 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 395495006833 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 395495006834 active site 395495006835 catalytic residues [active] 395495006836 metal binding site [ion binding]; metal-binding site 395495006837 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 395495006838 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395495006839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495006840 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395495006841 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395495006842 carboxyltransferase (CT) interaction site; other site 395495006843 biotinylation site [posttranslational modification]; other site 395495006844 enoyl-CoA hydratase; Provisional; Region: PRK05995 395495006845 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495006846 substrate binding site [chemical binding]; other site 395495006847 oxyanion hole (OAH) forming residues; other site 395495006848 trimer interface [polypeptide binding]; other site 395495006849 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395495006850 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395495006851 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395495006852 isovaleryl-CoA dehydrogenase; Region: PLN02519 395495006853 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 395495006854 substrate binding site [chemical binding]; other site 395495006855 FAD binding site [chemical binding]; other site 395495006856 catalytic base [active] 395495006857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495006858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495006859 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 395495006860 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 395495006861 Acyltransferase family; Region: Acyl_transf_3; pfam01757 395495006862 5-oxoprolinase; Region: PLN02666 395495006863 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 395495006864 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 395495006865 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 395495006866 Methyltransferase domain; Region: Methyltransf_23; pfam13489 395495006867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495006868 S-adenosylmethionine binding site [chemical binding]; other site 395495006869 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 395495006870 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 395495006871 FMN binding site [chemical binding]; other site 395495006872 active site 395495006873 catalytic residues [active] 395495006874 substrate binding site [chemical binding]; other site 395495006875 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 395495006876 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495006877 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495006878 catalytic loop [active] 395495006879 iron binding site [ion binding]; other site 395495006880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 395495006881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495006882 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 395495006883 hypothetical protein; Provisional; Region: PRK01254 395495006884 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 395495006885 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 395495006886 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 395495006887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395495006888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495006889 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 395495006890 Walker A/P-loop; other site 395495006891 ATP binding site [chemical binding]; other site 395495006892 Q-loop/lid; other site 395495006893 ABC transporter signature motif; other site 395495006894 Walker B; other site 395495006895 D-loop; other site 395495006896 H-loop/switch region; other site 395495006897 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 395495006898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495006899 substrate binding pocket [chemical binding]; other site 395495006900 membrane-bound complex binding site; other site 395495006901 hinge residues; other site 395495006902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495006903 dimer interface [polypeptide binding]; other site 395495006904 conserved gate region; other site 395495006905 putative PBP binding loops; other site 395495006906 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 395495006907 ABC-ATPase subunit interface; other site 395495006908 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 395495006909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495006910 dimer interface [polypeptide binding]; other site 395495006911 conserved gate region; other site 395495006912 putative PBP binding loops; other site 395495006913 ABC-ATPase subunit interface; other site 395495006914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395495006915 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 395495006916 Walker A/P-loop; other site 395495006917 ATP binding site [chemical binding]; other site 395495006918 Q-loop/lid; other site 395495006919 ABC transporter signature motif; other site 395495006920 Walker B; other site 395495006921 D-loop; other site 395495006922 H-loop/switch region; other site 395495006923 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 395495006924 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 395495006925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495006926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495006927 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495006928 putative effector binding pocket; other site 395495006929 dimerization interface [polypeptide binding]; other site 395495006930 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 395495006931 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 395495006932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495006933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495006934 active site 395495006935 catalytic tetrad [active] 395495006936 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 395495006937 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 395495006938 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 395495006939 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 395495006940 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 395495006941 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 395495006942 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 395495006943 dimer interface [polypeptide binding]; other site 395495006944 PYR/PP interface [polypeptide binding]; other site 395495006945 TPP binding site [chemical binding]; other site 395495006946 substrate binding site [chemical binding]; other site 395495006947 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 395495006948 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 395495006949 TPP-binding site [chemical binding]; other site 395495006950 putative dimer interface [polypeptide binding]; other site 395495006951 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 395495006952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495006953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495006954 4Fe-4S binding domain; Region: Fer4; pfam00037 395495006955 hypothetical protein; Provisional; Region: PRK11622 395495006956 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 395495006957 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 395495006958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495006959 dimer interface [polypeptide binding]; other site 395495006960 conserved gate region; other site 395495006961 putative PBP binding loops; other site 395495006962 ABC-ATPase subunit interface; other site 395495006963 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 395495006964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495006965 Walker A/P-loop; other site 395495006966 ATP binding site [chemical binding]; other site 395495006967 Q-loop/lid; other site 395495006968 ABC transporter signature motif; other site 395495006969 Walker B; other site 395495006970 D-loop; other site 395495006971 H-loop/switch region; other site 395495006972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495006973 putative substrate translocation pore; other site 395495006974 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 395495006975 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 395495006976 Thioredoxin; Region: Thioredoxin_4; pfam13462 395495006977 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 395495006978 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395495006979 dimerization interface [polypeptide binding]; other site 395495006980 active site 395495006981 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 395495006982 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 395495006983 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 395495006984 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 395495006985 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 395495006986 iron-sulfur cluster [ion binding]; other site 395495006987 [2Fe-2S] cluster binding site [ion binding]; other site 395495006988 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 395495006989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495006990 dimerization interface [polypeptide binding]; other site 395495006991 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495006992 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495006993 dimer interface [polypeptide binding]; other site 395495006994 putative CheW interface [polypeptide binding]; other site 395495006995 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 395495006996 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 395495006997 HipA-like N-terminal domain; Region: HipA_N; pfam07805 395495006998 HipA-like C-terminal domain; Region: HipA_C; pfam07804 395495006999 Predicted membrane protein [Function unknown]; Region: COG2855 395495007000 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 395495007001 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 395495007002 dimer interface [polypeptide binding]; other site 395495007003 acyl-activating enzyme (AAE) consensus motif; other site 395495007004 putative active site [active] 395495007005 AMP binding site [chemical binding]; other site 395495007006 putative CoA binding site [chemical binding]; other site 395495007007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495007008 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 395495007009 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 395495007010 NADP binding site [chemical binding]; other site 395495007011 dimer interface [polypeptide binding]; other site 395495007012 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 395495007013 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 395495007014 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 395495007015 AAA domain; Region: AAA_22; pfam13401 395495007016 AAA ATPase domain; Region: AAA_16; pfam13191 395495007017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495007018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495007019 DNA binding residues [nucleotide binding] 395495007020 dimerization interface [polypeptide binding]; other site 395495007021 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 395495007022 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 395495007023 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 395495007024 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 395495007025 AAA domain; Region: AAA_25; pfam13481 395495007026 Helix-turn-helix domain; Region: HTH_17; pfam12728 395495007027 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 395495007028 integrase; Provisional; Region: PRK09692 395495007029 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 395495007030 active site 395495007031 Int/Topo IB signature motif; other site 395495007032 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 395495007033 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 395495007034 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 395495007035 dimer interface [polypeptide binding]; other site 395495007036 substrate binding site [chemical binding]; other site 395495007037 ATP binding site [chemical binding]; other site 395495007038 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 395495007039 thiamine phosphate binding site [chemical binding]; other site 395495007040 active site 395495007041 pyrophosphate binding site [ion binding]; other site 395495007042 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 395495007043 substrate binding site [chemical binding]; other site 395495007044 multimerization interface [polypeptide binding]; other site 395495007045 ATP binding site [chemical binding]; other site 395495007046 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 395495007047 N- and C-terminal domain interface [polypeptide binding]; other site 395495007048 putative active site [active] 395495007049 putative MgATP binding site [chemical binding]; other site 395495007050 putative catalytic site [active] 395495007051 metal binding site [ion binding]; metal-binding site 395495007052 putative carbohydrate binding site [chemical binding]; other site 395495007053 Domain of unknown function (DUF718); Region: DUF718; pfam05336 395495007054 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495007055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495007056 TM-ABC transporter signature motif; other site 395495007057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495007058 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495007059 TM-ABC transporter signature motif; other site 395495007060 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 395495007061 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495007062 Walker A/P-loop; other site 395495007063 ATP binding site [chemical binding]; other site 395495007064 Q-loop/lid; other site 395495007065 ABC transporter signature motif; other site 395495007066 Walker B; other site 395495007067 D-loop; other site 395495007068 H-loop/switch region; other site 395495007069 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495007070 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 395495007071 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 395495007072 ligand binding site [chemical binding]; other site 395495007073 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 395495007074 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 395495007075 short chain dehydrogenase; Validated; Region: PRK08324 395495007076 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 395495007077 active site 395495007078 Zn2+ binding site [ion binding]; other site 395495007079 intersubunit interface [polypeptide binding]; other site 395495007080 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 395495007081 putative NAD(P) binding site [chemical binding]; other site 395495007082 active site 395495007083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495007084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495007085 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 395495007086 putative dimerization interface [polypeptide binding]; other site 395495007087 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 395495007088 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 395495007089 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 395495007090 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 395495007091 Predicted transcriptional regulator [Transcription]; Region: COG4190 395495007092 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 395495007093 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395495007094 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 395495007095 putative substrate binding site [chemical binding]; other site 395495007096 putative ATP binding site [chemical binding]; other site 395495007097 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 395495007098 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495007099 ligand binding site [chemical binding]; other site 395495007100 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495007101 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495007102 TM-ABC transporter signature motif; other site 395495007103 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395495007104 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495007105 Walker A/P-loop; other site 395495007106 ATP binding site [chemical binding]; other site 395495007107 Q-loop/lid; other site 395495007108 ABC transporter signature motif; other site 395495007109 Walker B; other site 395495007110 D-loop; other site 395495007111 H-loop/switch region; other site 395495007112 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 395495007113 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495007114 non-specific DNA interactions [nucleotide binding]; other site 395495007115 DNA binding site [nucleotide binding] 395495007116 sequence specific DNA binding site [nucleotide binding]; other site 395495007117 putative cAMP binding site [chemical binding]; other site 395495007118 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 395495007119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395495007120 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 395495007121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495007122 ATP binding site [chemical binding]; other site 395495007123 putative Mg++ binding site [ion binding]; other site 395495007124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495007125 nucleotide binding region [chemical binding]; other site 395495007126 ATP-binding site [chemical binding]; other site 395495007127 Helicase associated domain (HA2); Region: HA2; pfam04408 395495007128 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 395495007129 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 395495007130 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 395495007131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495007132 N-acetylglutamate synthase; Validated; Region: PRK05279 395495007133 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 395495007134 putative feedback inhibition sensing region; other site 395495007135 putative nucleotide binding site [chemical binding]; other site 395495007136 putative substrate binding site [chemical binding]; other site 395495007137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495007138 Coenzyme A binding pocket [chemical binding]; other site 395495007139 oxidative damage protection protein; Provisional; Region: PRK05408 395495007140 Putative phage tail protein; Region: Phage-tail_3; pfam13550 395495007141 glycolate oxidase; Region: PLN02979 395495007142 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 395495007143 Phage-related minor tail protein [Function unknown]; Region: COG5281 395495007144 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 395495007145 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 395495007146 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 395495007147 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 395495007148 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 395495007149 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 395495007150 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 395495007151 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 395495007152 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 395495007153 Protein of unknown function (DUF935); Region: DUF935; pfam06074 395495007154 Protein of unknown function (DUF935); Region: DUF935; pfam06074 395495007155 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 395495007156 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 395495007157 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 395495007158 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 395495007159 putative active site [active] 395495007160 putative NTP binding site [chemical binding]; other site 395495007161 putative nucleic acid binding site [nucleotide binding]; other site 395495007162 Peptidase M15; Region: Peptidase_M15_3; cl01194 395495007163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 395495007164 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 395495007165 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 395495007166 Integrase core domain; Region: rve; pfam00665 395495007167 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 395495007168 HTH domain; Region: HTH_11; pfam08279 395495007169 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 395495007170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495007171 Transposase; Region: HTH_Tnp_1; pfam01527 395495007172 putative transposase OrfB; Reviewed; Region: PHA02517 395495007173 Integrase core domain; Region: rve; pfam00665 395495007174 Integrase core domain; Region: rve_3; pfam13683 395495007175 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 395495007176 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 395495007177 Mor transcription activator family; Region: Mor; cl02360 395495007178 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 395495007179 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395495007180 H-NS histone family; Region: Histone_HNS; pfam00816 395495007181 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 395495007182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 395495007183 NlpC/P60 family; Region: NLPC_P60; pfam00877 395495007184 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 395495007185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495007186 FeS/SAM binding site; other site 395495007187 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 395495007188 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 395495007189 homotrimer interaction site [polypeptide binding]; other site 395495007190 zinc binding site [ion binding]; other site 395495007191 CDP-binding sites; other site 395495007192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495007193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495007194 NAD(P) binding site [chemical binding]; other site 395495007195 active site 395495007196 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 395495007197 substrate binding site; other site 395495007198 dimer interface; other site 395495007199 Response regulator receiver domain; Region: Response_reg; pfam00072 395495007200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007201 active site 395495007202 phosphorylation site [posttranslational modification] 395495007203 intermolecular recognition site; other site 395495007204 dimerization interface [polypeptide binding]; other site 395495007205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007206 dimer interface [polypeptide binding]; other site 395495007207 phosphorylation site [posttranslational modification] 395495007208 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 395495007209 Mg2+ binding site [ion binding]; other site 395495007210 G-X-G motif; other site 395495007211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495007212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007213 dimer interface [polypeptide binding]; other site 395495007214 phosphorylation site [posttranslational modification] 395495007215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007216 ATP binding site [chemical binding]; other site 395495007217 Mg2+ binding site [ion binding]; other site 395495007218 G-X-G motif; other site 395495007219 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 395495007220 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 395495007221 heme binding site [chemical binding]; other site 395495007222 substrate binding site [chemical binding]; other site 395495007223 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 395495007224 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 395495007225 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 395495007226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495007227 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 395495007228 Walker A/P-loop; other site 395495007229 ATP binding site [chemical binding]; other site 395495007230 Q-loop/lid; other site 395495007231 ABC transporter signature motif; other site 395495007232 Walker B; other site 395495007233 D-loop; other site 395495007234 H-loop/switch region; other site 395495007235 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 395495007236 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 395495007237 lipoyl-biotinyl attachment site [posttranslational modification]; other site 395495007238 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495007239 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 395495007240 Transmembrane secretion effector; Region: MFS_3; pfam05977 395495007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495007242 putative substrate translocation pore; other site 395495007243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 395495007244 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 395495007245 Winged helix-turn helix; Region: HTH_29; pfam13551 395495007246 Homeodomain-like domain; Region: HTH_32; pfam13565 395495007247 Integrase core domain; Region: rve; pfam00665 395495007248 DDE domain; Region: DDE_Tnp_IS240; pfam13610 395495007249 Integrase core domain; Region: rve_3; pfam13683 395495007250 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 395495007251 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 395495007252 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495007253 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 395495007254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495007255 Walker A motif; other site 395495007256 ATP binding site [chemical binding]; other site 395495007257 Walker B motif; other site 395495007258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495007259 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 395495007260 putative active site [active] 395495007261 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 395495007262 active site 395495007263 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495007264 MoxR-like ATPases [General function prediction only]; Region: COG0714 395495007265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495007266 Walker A motif; other site 395495007267 ATP binding site [chemical binding]; other site 395495007268 Walker B motif; other site 395495007269 arginine finger; other site 395495007270 Protein of unknown function DUF58; Region: DUF58; pfam01882 395495007271 von Willebrand factor type A domain; Region: VWA_2; pfam13519 395495007272 metal ion-dependent adhesion site (MIDAS); other site 395495007273 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 395495007274 Bacterial sugar transferase; Region: Bac_transf; pfam02397 395495007275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495007276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495007277 putative substrate translocation pore; other site 395495007278 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 395495007279 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395495007280 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 395495007281 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 395495007282 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 395495007283 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 395495007284 PEP-CTERM motif; Region: VPEP; pfam07589 395495007285 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 395495007286 PEP-CTERM motif; Region: VPEP; pfam07589 395495007287 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 395495007288 homotrimer interaction site [polypeptide binding]; other site 395495007289 putative active site [active] 395495007290 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 395495007291 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 395495007292 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 395495007293 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395495007294 active site 395495007295 NTP binding site [chemical binding]; other site 395495007296 metal binding triad [ion binding]; metal-binding site 395495007297 antibiotic binding site [chemical binding]; other site 395495007298 Protein of unknown function DUF86; Region: DUF86; pfam01934 395495007299 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 395495007300 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 395495007301 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 395495007302 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 395495007303 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 395495007304 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 395495007305 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 395495007306 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 395495007307 Right handed beta helix region; Region: Beta_helix; pfam13229 395495007308 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 395495007309 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 395495007310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395495007311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 395495007312 active site 395495007313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495007314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495007315 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 395495007316 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 395495007317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 395495007318 active site 395495007319 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 395495007320 O-Antigen ligase; Region: Wzy_C; pfam04932 395495007321 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 395495007322 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 395495007323 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 395495007324 Substrate binding site; other site 395495007325 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 395495007326 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 395495007327 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 395495007328 NADP-binding site; other site 395495007329 homotetramer interface [polypeptide binding]; other site 395495007330 substrate binding site [chemical binding]; other site 395495007331 homodimer interface [polypeptide binding]; other site 395495007332 active site 395495007333 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 395495007334 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 395495007335 NADP binding site [chemical binding]; other site 395495007336 active site 395495007337 putative substrate binding site [chemical binding]; other site 395495007338 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 395495007339 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 395495007340 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 395495007341 Fibronectin type 3 domain; Region: FN3; smart00060 395495007342 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 395495007343 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 395495007344 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 395495007345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 395495007346 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 395495007347 putative active site [active] 395495007348 AAA domain; Region: AAA_14; pfam13173 395495007349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495007350 dimerization interface [polypeptide binding]; other site 395495007351 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495007352 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495007353 dimer interface [polypeptide binding]; other site 395495007354 putative CheW interface [polypeptide binding]; other site 395495007355 Cache domain; Region: Cache_2; cl07034 395495007356 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 395495007357 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495007358 chain length determinant protein EpsF; Region: EpsF; TIGR03017 395495007359 Chain length determinant protein; Region: Wzz; cl15801 395495007360 Chain length determinant protein; Region: Wzz; cl15801 395495007361 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 395495007362 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 395495007363 SLBB domain; Region: SLBB; pfam10531 395495007364 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 395495007365 SurA N-terminal domain; Region: SurA_N_3; cl07813 395495007366 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 395495007367 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395495007368 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495007369 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495007370 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 395495007371 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 395495007372 active site 395495007373 acyl-CoA synthetase; Validated; Region: PRK07470 395495007374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495007375 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 395495007376 acyl-activating enzyme (AAE) consensus motif; other site 395495007377 putative AMP binding site [chemical binding]; other site 395495007378 putative active site [active] 395495007379 putative CoA binding site [chemical binding]; other site 395495007380 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495007381 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495007382 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 395495007383 DctM-like transporters; Region: DctM; pfam06808 395495007384 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495007385 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 395495007386 classical (c) SDRs; Region: SDR_c; cd05233 395495007387 NAD(P) binding site [chemical binding]; other site 395495007388 active site 395495007389 hypothetical protein; Provisional; Region: PRK12378 395495007390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495007391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495007392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395495007393 dimerization interface [polypeptide binding]; other site 395495007394 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495007395 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 395495007396 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 395495007397 metal binding site [ion binding]; metal-binding site 395495007398 putative dimer interface [polypeptide binding]; other site 395495007399 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 395495007400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495007401 Transposase; Region: HTH_Tnp_1; pfam01527 395495007402 putative transposase OrfB; Reviewed; Region: PHA02517 395495007403 Integrase core domain; Region: rve; pfam00665 395495007404 Integrase core domain; Region: rve_3; pfam13683 395495007405 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 395495007406 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 395495007407 active site 395495007408 Int/Topo IB signature motif; other site 395495007409 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 395495007410 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 395495007411 active site 395495007412 metal binding site [ion binding]; metal-binding site 395495007413 Domain of unknown function DUF21; Region: DUF21; pfam01595 395495007414 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395495007415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395495007416 Transporter associated domain; Region: CorC_HlyC; smart01091 395495007417 SapC; Region: SapC; pfam07277 395495007418 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 395495007419 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 395495007420 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 395495007421 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 395495007422 putative active site [active] 395495007423 putative metal binding site [ion binding]; other site 395495007424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495007425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495007426 ligand binding site [chemical binding]; other site 395495007427 flexible hinge region; other site 395495007428 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395495007429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495007430 S-adenosylmethionine binding site [chemical binding]; other site 395495007431 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 395495007432 G1 box; other site 395495007433 GTP/Mg2+ binding site [chemical binding]; other site 395495007434 G2 box; other site 395495007435 Switch I region; other site 395495007436 G3 box; other site 395495007437 Switch II region; other site 395495007438 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 395495007439 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495007440 Walker A/P-loop; other site 395495007441 ATP binding site [chemical binding]; other site 395495007442 Q-loop/lid; other site 395495007443 ABC transporter signature motif; other site 395495007444 Walker B; other site 395495007445 D-loop; other site 395495007446 H-loop/switch region; other site 395495007447 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 395495007448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395495007449 FtsX-like permease family; Region: FtsX; pfam02687 395495007450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 395495007451 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 395495007452 DHH family; Region: DHH; pfam01368 395495007453 DHHA1 domain; Region: DHHA1; pfam02272 395495007454 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395495007455 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 395495007456 putative ligand binding site [chemical binding]; other site 395495007457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495007458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495007459 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495007460 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 395495007461 acyl-activating enzyme (AAE) consensus motif; other site 395495007462 AMP binding site [chemical binding]; other site 395495007463 active site 395495007464 CoA binding site [chemical binding]; other site 395495007465 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395495007466 CoenzymeA binding site [chemical binding]; other site 395495007467 subunit interaction site [polypeptide binding]; other site 395495007468 PHB binding site; other site 395495007469 enoyl-CoA hydratase; Provisional; Region: PRK08140 395495007470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495007471 substrate binding site [chemical binding]; other site 395495007472 oxyanion hole (OAH) forming residues; other site 395495007473 trimer interface [polypeptide binding]; other site 395495007474 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 395495007475 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 395495007476 putative trimer interface [polypeptide binding]; other site 395495007477 putative metal binding site [ion binding]; other site 395495007478 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495007479 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495007480 DNA binding site [nucleotide binding] 395495007481 domain linker motif; other site 395495007482 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 395495007483 putative dimerization interface [polypeptide binding]; other site 395495007484 putative ligand binding site [chemical binding]; other site 395495007485 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495007486 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 395495007487 Walker A/P-loop; other site 395495007488 ATP binding site [chemical binding]; other site 395495007489 Q-loop/lid; other site 395495007490 ABC transporter signature motif; other site 395495007491 Walker B; other site 395495007492 D-loop; other site 395495007493 H-loop/switch region; other site 395495007494 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495007495 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495007496 TM-ABC transporter signature motif; other site 395495007497 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 395495007498 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495007499 putative ligand binding site [chemical binding]; other site 395495007500 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 395495007501 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495007502 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495007503 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495007504 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 395495007505 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 395495007506 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 395495007507 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395495007508 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395495007509 shikimate binding site; other site 395495007510 NAD(P) binding site [chemical binding]; other site 395495007511 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395495007512 Uncharacterized conserved protein [Function unknown]; Region: COG3777 395495007513 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395495007514 active site 2 [active] 395495007515 active site 1 [active] 395495007516 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495007517 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495007518 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 395495007519 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 395495007520 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 395495007521 tetramer interface [polypeptide binding]; other site 395495007522 active site 395495007523 Histidine kinase; Region: HisKA_3; pfam07730 395495007524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007525 Mg2+ binding site [ion binding]; other site 395495007526 G-X-G motif; other site 395495007527 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 395495007528 glutathione s-transferase; Provisional; Region: PTZ00057 395495007529 GSH binding site (G-site) [chemical binding]; other site 395495007530 C-terminal domain interface [polypeptide binding]; other site 395495007531 dimer interface [polypeptide binding]; other site 395495007532 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 395495007533 dimer interface [polypeptide binding]; other site 395495007534 N-terminal domain interface [polypeptide binding]; other site 395495007535 substrate binding pocket (H-site) [chemical binding]; other site 395495007536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495007537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495007538 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 395495007539 putative dimerization interface [polypeptide binding]; other site 395495007540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 395495007541 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495007542 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495007543 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495007544 trimer interface [polypeptide binding]; other site 395495007545 eyelet of channel; other site 395495007546 NIPSNAP; Region: NIPSNAP; pfam07978 395495007547 NIPSNAP; Region: NIPSNAP; pfam07978 395495007548 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395495007549 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395495007550 shikimate binding site; other site 395495007551 NAD(P) binding site [chemical binding]; other site 395495007552 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495007553 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395495007554 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495007555 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 395495007556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495007557 Predicted oxidoreductase [General function prediction only]; Region: COG3573 395495007558 RES domain; Region: RES; pfam08808 395495007559 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 395495007560 ThiC-associated domain; Region: ThiC-associated; pfam13667 395495007561 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 395495007562 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 395495007563 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 395495007564 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 395495007565 thiS-thiF/thiG interaction site; other site 395495007566 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 395495007567 ThiS interaction site; other site 395495007568 putative active site [active] 395495007569 tetramer interface [polypeptide binding]; other site 395495007570 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 395495007571 substrate binding site [chemical binding]; other site 395495007572 ATP binding site [chemical binding]; other site 395495007573 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 395495007574 thiamine phosphate binding site [chemical binding]; other site 395495007575 active site 395495007576 pyrophosphate binding site [ion binding]; other site 395495007577 Predicted methyltransferase [General function prediction only]; Region: COG3897 395495007578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495007579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495007580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495007581 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 395495007582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495007583 S-adenosylmethionine binding site [chemical binding]; other site 395495007584 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395495007585 active site residue [active] 395495007586 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 395495007587 BNR repeat-like domain; Region: BNR_2; pfam13088 395495007588 charged pocket; other site 395495007589 ThiS family; Region: ThiS; pfam02597 395495007590 hydrophobic patch; other site 395495007591 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 395495007592 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 395495007593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495007594 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 395495007595 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 395495007596 active site 395495007597 substrate binding site [chemical binding]; other site 395495007598 metal binding site [ion binding]; metal-binding site 395495007599 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 395495007600 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 395495007601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495007602 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 395495007603 HupF/HypC family; Region: HupF_HypC; pfam01455 395495007604 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 395495007605 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 395495007606 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 395495007607 dimerization interface [polypeptide binding]; other site 395495007608 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 395495007609 ATP binding site [chemical binding]; other site 395495007610 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 395495007611 putative active site [active] 395495007612 putative substrate binding site [chemical binding]; other site 395495007613 putative cosubstrate binding site; other site 395495007614 catalytic site [active] 395495007615 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 395495007616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495007617 substrate binding site [chemical binding]; other site 395495007618 oxyanion hole (OAH) forming residues; other site 395495007619 trimer interface [polypeptide binding]; other site 395495007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007621 dimer interface [polypeptide binding]; other site 395495007622 phosphorylation site [posttranslational modification] 395495007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007624 ATP binding site [chemical binding]; other site 395495007625 Mg2+ binding site [ion binding]; other site 395495007626 G-X-G motif; other site 395495007627 Response regulator receiver domain; Region: Response_reg; pfam00072 395495007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007629 active site 395495007630 phosphorylation site [posttranslational modification] 395495007631 intermolecular recognition site; other site 395495007632 dimerization interface [polypeptide binding]; other site 395495007633 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 395495007634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007635 active site 395495007636 phosphorylation site [posttranslational modification] 395495007637 intermolecular recognition site; other site 395495007638 dimerization interface [polypeptide binding]; other site 395495007639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495007640 Zn2+ binding site [ion binding]; other site 395495007641 Mg2+ binding site [ion binding]; other site 395495007642 enoyl-CoA hydratase; Provisional; Region: PRK09245 395495007643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495007644 substrate binding site [chemical binding]; other site 395495007645 oxyanion hole (OAH) forming residues; other site 395495007646 trimer interface [polypeptide binding]; other site 395495007647 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395495007648 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495007649 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 395495007650 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 395495007651 NAD binding site [chemical binding]; other site 395495007652 homotetramer interface [polypeptide binding]; other site 395495007653 homodimer interface [polypeptide binding]; other site 395495007654 active site 395495007655 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 395495007656 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495007657 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 395495007658 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495007659 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495007660 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 395495007661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495007662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495007663 dimerization interface [polypeptide binding]; other site 395495007664 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 395495007665 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 395495007666 dimer interface [polypeptide binding]; other site 395495007667 NADP binding site [chemical binding]; other site 395495007668 catalytic residues [active] 395495007669 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 395495007670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495007671 substrate binding site [chemical binding]; other site 395495007672 oxyanion hole (OAH) forming residues; other site 395495007673 trimer interface [polypeptide binding]; other site 395495007674 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 395495007675 30S subunit binding site; other site 395495007676 tellurium resistance terB-like protein; Region: terB_like; cl11965 395495007677 metal binding site [ion binding]; metal-binding site 395495007678 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 395495007679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495007680 Walker A motif; other site 395495007681 ATP binding site [chemical binding]; other site 395495007682 Walker B motif; other site 395495007683 arginine finger; other site 395495007684 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 395495007685 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 395495007686 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395495007687 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 395495007688 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 395495007689 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 395495007690 MASE1; Region: MASE1; cl17823 395495007691 PAS fold; Region: PAS; pfam00989 395495007692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495007693 putative active site [active] 395495007694 heme pocket [chemical binding]; other site 395495007695 PAS fold; Region: PAS_4; pfam08448 395495007696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495007697 putative active site [active] 395495007698 heme pocket [chemical binding]; other site 395495007699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495007700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495007701 metal binding site [ion binding]; metal-binding site 395495007702 active site 395495007703 I-site; other site 395495007704 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 395495007705 MG2 domain; Region: A2M_N; pfam01835 395495007706 Alpha-2-macroglobulin family; Region: A2M; pfam00207 395495007707 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 395495007708 surface patch; other site 395495007709 thioester region; other site 395495007710 specificity defining residues; other site 395495007711 penicillin-binding protein 1C; Provisional; Region: PRK11240 395495007712 Transglycosylase; Region: Transgly; pfam00912 395495007713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 395495007714 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 395495007715 B12 binding domain; Region: B12-binding_2; pfam02607 395495007716 B12 binding domain; Region: B12-binding; pfam02310 395495007717 B12 binding site [chemical binding]; other site 395495007718 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 395495007719 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 395495007720 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 395495007721 FAD binding pocket [chemical binding]; other site 395495007722 FAD binding motif [chemical binding]; other site 395495007723 phosphate binding motif [ion binding]; other site 395495007724 beta-alpha-beta structure motif; other site 395495007725 NAD binding pocket [chemical binding]; other site 395495007726 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 395495007727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495007728 dimerization interface [polypeptide binding]; other site 395495007729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007730 dimer interface [polypeptide binding]; other site 395495007731 phosphorylation site [posttranslational modification] 395495007732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007733 ATP binding site [chemical binding]; other site 395495007734 Mg2+ binding site [ion binding]; other site 395495007735 G-X-G motif; other site 395495007736 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 395495007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007738 active site 395495007739 phosphorylation site [posttranslational modification] 395495007740 intermolecular recognition site; other site 395495007741 dimerization interface [polypeptide binding]; other site 395495007742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495007743 DNA binding site [nucleotide binding] 395495007744 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395495007745 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 395495007746 substrate binding site [chemical binding]; other site 395495007747 ATP binding site [chemical binding]; other site 395495007748 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 395495007749 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495007750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495007751 putative active site [active] 395495007752 heme pocket [chemical binding]; other site 395495007753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007754 dimer interface [polypeptide binding]; other site 395495007755 phosphorylation site [posttranslational modification] 395495007756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007757 ATP binding site [chemical binding]; other site 395495007758 Mg2+ binding site [ion binding]; other site 395495007759 G-X-G motif; other site 395495007760 Response regulator receiver domain; Region: Response_reg; pfam00072 395495007761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007762 active site 395495007763 phosphorylation site [posttranslational modification] 395495007764 intermolecular recognition site; other site 395495007765 dimerization interface [polypeptide binding]; other site 395495007766 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495007767 galactarate dehydratase; Region: galactar-dH20; TIGR03248 395495007768 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 395495007769 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 395495007770 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495007771 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 395495007772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 395495007773 Beta-Casp domain; Region: Beta-Casp; smart01027 395495007774 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 395495007775 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 395495007776 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 395495007777 GTP/Mg2+ binding site [chemical binding]; other site 395495007778 G4 box; other site 395495007779 G5 box; other site 395495007780 G1 box; other site 395495007781 Switch I region; other site 395495007782 G2 box; other site 395495007783 G3 box; other site 395495007784 Switch II region; other site 395495007785 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 395495007786 active site 395495007787 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 395495007788 dimerization interface [polypeptide binding]; other site 395495007789 active site 395495007790 Coenzyme A transferase; Region: CoA_trans; cl17247 395495007791 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 395495007792 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 395495007793 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 395495007794 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 395495007795 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 395495007796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495007797 active site 395495007798 thymidine phosphorylase; Provisional; Region: PRK04350 395495007799 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395495007800 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395495007801 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 395495007802 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 395495007803 AAA ATPase domain; Region: AAA_16; pfam13191 395495007804 Protein of unknown function, DUF485; Region: DUF485; pfam04341 395495007805 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 395495007806 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 395495007807 Na binding site [ion binding]; other site 395495007808 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 395495007809 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 395495007810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495007811 putative active site [active] 395495007812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495007813 heme pocket [chemical binding]; other site 395495007814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007815 dimer interface [polypeptide binding]; other site 395495007816 phosphorylation site [posttranslational modification] 395495007817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007818 ATP binding site [chemical binding]; other site 395495007819 Mg2+ binding site [ion binding]; other site 395495007820 G-X-G motif; other site 395495007821 Response regulator receiver domain; Region: Response_reg; pfam00072 395495007822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007823 active site 395495007824 phosphorylation site [posttranslational modification] 395495007825 intermolecular recognition site; other site 395495007826 dimerization interface [polypeptide binding]; other site 395495007827 Response regulator receiver domain; Region: Response_reg; pfam00072 395495007828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007829 active site 395495007830 phosphorylation site [posttranslational modification] 395495007831 intermolecular recognition site; other site 395495007832 dimerization interface [polypeptide binding]; other site 395495007833 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 395495007834 putative binding surface; other site 395495007835 active site 395495007836 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 395495007837 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 395495007838 active site 395495007839 catalytic site [active] 395495007840 substrate binding site [chemical binding]; other site 395495007841 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 395495007842 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495007843 ligand binding site [chemical binding]; other site 395495007844 flexible hinge region; other site 395495007845 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 395495007846 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395495007847 metal binding triad; other site 395495007848 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 395495007849 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 395495007850 nucleotide binding pocket [chemical binding]; other site 395495007851 K-X-D-G motif; other site 395495007852 catalytic site [active] 395495007853 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 395495007854 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 395495007855 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 395495007856 Dimer interface [polypeptide binding]; other site 395495007857 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 395495007858 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 395495007859 DEAD-like helicases superfamily; Region: DEXDc2; smart00488 395495007860 DEAD_2; Region: DEAD_2; pfam06733 395495007861 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 395495007862 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 395495007863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 395495007864 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 395495007865 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 395495007866 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395495007867 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 395495007868 Walker A/P-loop; other site 395495007869 ATP binding site [chemical binding]; other site 395495007870 Q-loop/lid; other site 395495007871 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 395495007872 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 395495007873 Q-loop/lid; other site 395495007874 ABC transporter signature motif; other site 395495007875 Walker B; other site 395495007876 D-loop; other site 395495007877 H-loop/switch region; other site 395495007878 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 395495007879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495007880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495007881 homodimer interface [polypeptide binding]; other site 395495007882 catalytic residue [active] 395495007883 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 395495007884 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 395495007885 active site 395495007886 substrate binding site [chemical binding]; other site 395495007887 trimer interface [polypeptide binding]; other site 395495007888 CoA binding site [chemical binding]; other site 395495007889 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 395495007890 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 395495007891 Walker A motif; other site 395495007892 ATP binding site [chemical binding]; other site 395495007893 Walker B motif; other site 395495007894 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 395495007895 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 395495007896 metal binding site [ion binding]; metal-binding site 395495007897 dimer interface [polypeptide binding]; other site 395495007898 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 395495007899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495007900 S-adenosylmethionine binding site [chemical binding]; other site 395495007901 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 395495007902 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 395495007903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495007904 RNA binding surface [nucleotide binding]; other site 395495007905 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 395495007906 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 395495007907 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395495007908 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395495007909 DEAD-like helicases superfamily; Region: DEXDc; smart00487 395495007910 ATP binding site [chemical binding]; other site 395495007911 Mg++ binding site [ion binding]; other site 395495007912 motif III; other site 395495007913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495007914 nucleotide binding region [chemical binding]; other site 395495007915 ATP-binding site [chemical binding]; other site 395495007916 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 395495007917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495007918 dimerization interface [polypeptide binding]; other site 395495007919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495007920 dimer interface [polypeptide binding]; other site 395495007921 phosphorylation site [posttranslational modification] 395495007922 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 395495007923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495007924 ATP binding site [chemical binding]; other site 395495007925 Mg2+ binding site [ion binding]; other site 395495007926 G-X-G motif; other site 395495007927 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495007928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495007929 active site 395495007930 phosphorylation site [posttranslational modification] 395495007931 intermolecular recognition site; other site 395495007932 dimerization interface [polypeptide binding]; other site 395495007933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495007934 DNA binding site [nucleotide binding] 395495007935 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 395495007936 dimer interface [polypeptide binding]; other site 395495007937 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 395495007938 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 395495007939 hypothetical protein; Provisional; Region: PRK05409 395495007940 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 395495007941 RNA polymerase sigma factor; Provisional; Region: PRK12520 395495007942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495007943 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 395495007944 DNA binding residues [nucleotide binding] 395495007945 Putative zinc-finger; Region: zf-HC2; pfam13490 395495007946 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 395495007947 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395495007948 FMN binding site [chemical binding]; other site 395495007949 substrate binding site [chemical binding]; other site 395495007950 putative catalytic residue [active] 395495007951 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 395495007952 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395495007953 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495007954 active site 395495007955 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 395495007956 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495007957 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495007958 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495007959 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495007960 Ligand binding site [chemical binding]; other site 395495007961 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495007962 glutamate racemase; Provisional; Region: PRK00865 395495007963 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 395495007964 Found in ATP-dependent protease La (LON); Region: LON; smart00464 395495007965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495007966 Walker A motif; other site 395495007967 ATP binding site [chemical binding]; other site 395495007968 Walker B motif; other site 395495007969 arginine finger; other site 395495007970 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 395495007971 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 395495007972 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 395495007973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495007974 Walker A motif; other site 395495007975 ATP binding site [chemical binding]; other site 395495007976 Walker B motif; other site 395495007977 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 395495007978 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 395495007979 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 395495007980 oligomer interface [polypeptide binding]; other site 395495007981 active site residues [active] 395495007982 trigger factor; Provisional; Region: tig; PRK01490 395495007983 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 395495007984 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 395495007985 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395495007986 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495007987 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495007988 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 395495007989 substrate binding pocket [chemical binding]; other site 395495007990 substrate-Mg2+ binding site; other site 395495007991 aspartate-rich region 1; other site 395495007992 aspartate-rich region 2; other site 395495007993 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 395495007994 active site lid residues [active] 395495007995 substrate binding pocket [chemical binding]; other site 395495007996 catalytic residues [active] 395495007997 substrate-Mg2+ binding site; other site 395495007998 aspartate-rich region 1; other site 395495007999 aspartate-rich region 2; other site 395495008000 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 395495008001 superoxide dismutase; Provisional; Region: PRK10543 395495008002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 395495008003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 395495008004 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 395495008005 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 395495008006 generic binding surface II; other site 395495008007 generic binding surface I; other site 395495008008 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 395495008009 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495008010 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495008011 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 395495008012 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 395495008013 Uncharacterized conserved protein [Function unknown]; Region: COG2835 395495008014 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 395495008015 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 395495008016 Ligand binding site; other site 395495008017 oligomer interface; other site 395495008018 adenylate kinase; Reviewed; Region: adk; PRK00279 395495008019 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 395495008020 AMP-binding site [chemical binding]; other site 395495008021 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 395495008022 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 395495008023 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 395495008024 NAD binding site [chemical binding]; other site 395495008025 homodimer interface [polypeptide binding]; other site 395495008026 homotetramer interface [polypeptide binding]; other site 395495008027 active site 395495008028 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 395495008029 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 395495008030 DNA primase, catalytic core; Region: dnaG; TIGR01391 395495008031 CHC2 zinc finger; Region: zf-CHC2; pfam01807 395495008032 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 395495008033 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 395495008034 active site 395495008035 metal binding site [ion binding]; metal-binding site 395495008036 interdomain interaction site; other site 395495008037 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 395495008038 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 395495008039 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 395495008040 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395495008041 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 395495008042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495008043 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 395495008044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495008045 DNA binding residues [nucleotide binding] 395495008046 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 395495008047 cyclase homology domain; Region: CHD; cd07302 395495008048 nucleotidyl binding site; other site 395495008049 metal binding site [ion binding]; metal-binding site 395495008050 dimer interface [polypeptide binding]; other site 395495008051 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 395495008052 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395495008053 phosphopeptide binding site; other site 395495008054 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 395495008055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495008056 motif II; other site 395495008057 ferrochelatase; Reviewed; Region: hemH; PRK00035 395495008058 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 395495008059 C-terminal domain interface [polypeptide binding]; other site 395495008060 active site 395495008061 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 395495008062 active site 395495008063 N-terminal domain interface [polypeptide binding]; other site 395495008064 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495008065 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495008066 trimer interface [polypeptide binding]; other site 395495008067 eyelet of channel; other site 395495008068 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 395495008069 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 395495008070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 395495008071 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495008072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008073 active site 395495008074 phosphorylation site [posttranslational modification] 395495008075 intermolecular recognition site; other site 395495008076 dimerization interface [polypeptide binding]; other site 395495008077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 395495008078 DNA binding site [nucleotide binding] 395495008079 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 395495008080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395495008081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008082 dimer interface [polypeptide binding]; other site 395495008083 phosphorylation site [posttranslational modification] 395495008084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008085 ATP binding site [chemical binding]; other site 395495008086 Mg2+ binding site [ion binding]; other site 395495008087 G-X-G motif; other site 395495008088 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495008089 RNA binding surface [nucleotide binding]; other site 395495008090 GrpE; Region: GrpE; pfam01025 395495008091 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 395495008092 dimer interface [polypeptide binding]; other site 395495008093 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 395495008094 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 395495008095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395495008096 nucleotide binding site [chemical binding]; other site 395495008097 chaperone protein DnaJ; Provisional; Region: PRK10767 395495008098 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395495008099 HSP70 interaction site [polypeptide binding]; other site 395495008100 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 395495008101 substrate binding site [polypeptide binding]; other site 395495008102 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 395495008103 Zn binding sites [ion binding]; other site 395495008104 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395495008105 dimer interface [polypeptide binding]; other site 395495008106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008107 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008108 active site 395495008109 phosphorylation site [posttranslational modification] 395495008110 intermolecular recognition site; other site 395495008111 dimerization interface [polypeptide binding]; other site 395495008112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495008113 binding surface 395495008114 TPR motif; other site 395495008115 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 395495008116 CoA-transferase family III; Region: CoA_transf_3; pfam02515 395495008117 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395495008118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495008119 substrate binding pocket [chemical binding]; other site 395495008120 membrane-bound complex binding site; other site 395495008121 hinge residues; other site 395495008122 PAS fold; Region: PAS_4; pfam08448 395495008123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008124 PAS domain; Region: PAS_9; pfam13426 395495008125 putative active site [active] 395495008126 heme pocket [chemical binding]; other site 395495008127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008129 metal binding site [ion binding]; metal-binding site 395495008130 active site 395495008131 I-site; other site 395495008132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495008133 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 395495008134 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 395495008135 active site 395495008136 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 395495008137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495008138 EamA-like transporter family; Region: EamA; pfam00892 395495008139 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 395495008140 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 395495008141 putative deacylase active site [active] 395495008142 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 395495008143 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 395495008144 catalytic residues [active] 395495008145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495008146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495008147 active site 395495008148 catalytic tetrad [active] 395495008149 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 395495008150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008151 active site 395495008152 phosphorylation site [posttranslational modification] 395495008153 intermolecular recognition site; other site 395495008154 dimerization interface [polypeptide binding]; other site 395495008155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495008156 Zn2+ binding site [ion binding]; other site 395495008157 Mg2+ binding site [ion binding]; other site 395495008158 PAS fold; Region: PAS_4; pfam08448 395495008159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008160 putative active site [active] 395495008161 heme pocket [chemical binding]; other site 395495008162 PAS domain S-box; Region: sensory_box; TIGR00229 395495008163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008164 putative active site [active] 395495008165 heme pocket [chemical binding]; other site 395495008166 PAS domain S-box; Region: sensory_box; TIGR00229 395495008167 PAS domain S-box; Region: sensory_box; TIGR00229 395495008168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008169 putative active site [active] 395495008170 heme pocket [chemical binding]; other site 395495008171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008172 PAS domain; Region: PAS_9; pfam13426 395495008173 putative active site [active] 395495008174 heme pocket [chemical binding]; other site 395495008175 PAS fold; Region: PAS_4; pfam08448 395495008176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008177 dimer interface [polypeptide binding]; other site 395495008178 phosphorylation site [posttranslational modification] 395495008179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008180 ATP binding site [chemical binding]; other site 395495008181 Mg2+ binding site [ion binding]; other site 395495008182 G-X-G motif; other site 395495008183 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008185 active site 395495008186 phosphorylation site [posttranslational modification] 395495008187 intermolecular recognition site; other site 395495008188 dimerization interface [polypeptide binding]; other site 395495008189 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395495008190 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395495008191 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 395495008192 dimerization interface [polypeptide binding]; other site 395495008193 ligand binding site [chemical binding]; other site 395495008194 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 395495008195 multifunctional aminopeptidase A; Provisional; Region: PRK00913 395495008196 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 395495008197 interface (dimer of trimers) [polypeptide binding]; other site 395495008198 Substrate-binding/catalytic site; other site 395495008199 Zn-binding sites [ion binding]; other site 395495008200 Predicted permeases [General function prediction only]; Region: COG0795 395495008201 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 395495008202 Predicted permeases [General function prediction only]; Region: COG0795 395495008203 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 395495008204 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 395495008205 putative active site [active] 395495008206 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 395495008207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495008208 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 395495008209 substrate binding site [chemical binding]; other site 395495008210 dimerization interface [polypeptide binding]; other site 395495008211 methionine aminotransferase; Validated; Region: PRK09082 395495008212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495008213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495008214 homodimer interface [polypeptide binding]; other site 395495008215 catalytic residue [active] 395495008216 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 395495008217 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 395495008218 C-terminal domain interface [polypeptide binding]; other site 395495008219 GSH binding site (G-site) [chemical binding]; other site 395495008220 dimer interface [polypeptide binding]; other site 395495008221 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 395495008222 N-terminal domain interface [polypeptide binding]; other site 395495008223 putative dimer interface [polypeptide binding]; other site 395495008224 active site 395495008225 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395495008226 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395495008227 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395495008228 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 395495008229 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 395495008230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 395495008231 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 395495008232 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395495008233 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395495008234 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 395495008235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 395495008236 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 395495008237 Uncharacterized conserved protein [Function unknown]; Region: COG2308 395495008238 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 395495008239 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 395495008240 Competence protein; Region: Competence; pfam03772 395495008241 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 395495008242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495008243 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 395495008244 homotrimer interaction site [polypeptide binding]; other site 395495008245 putative active site [active] 395495008246 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 395495008247 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 395495008248 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 395495008249 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495008250 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495008251 catalytic residue [active] 395495008252 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495008253 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 395495008254 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 395495008255 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 395495008256 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495008257 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495008258 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 395495008259 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395495008260 Walker A motif; other site 395495008261 ATP binding site [chemical binding]; other site 395495008262 Walker B motif; other site 395495008263 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 395495008264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495008265 TPR motif; other site 395495008266 binding surface 395495008267 Tetratricopeptide repeat; Region: TPR_16; pfam13432 395495008268 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 395495008269 Secretin and TonB N terminus short domain; Region: STN; smart00965 395495008270 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495008271 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495008272 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 395495008273 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495008274 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 395495008275 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 395495008276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495008277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 395495008278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008279 dimer interface [polypeptide binding]; other site 395495008280 phosphorylation site [posttranslational modification] 395495008281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008282 ATP binding site [chemical binding]; other site 395495008283 Mg2+ binding site [ion binding]; other site 395495008284 G-X-G motif; other site 395495008285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495008286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008287 active site 395495008288 phosphorylation site [posttranslational modification] 395495008289 intermolecular recognition site; other site 395495008290 dimerization interface [polypeptide binding]; other site 395495008291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495008292 DNA binding site [nucleotide binding] 395495008293 Uncharacterized conserved protein [Function unknown]; Region: COG3391 395495008294 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495008295 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495008296 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495008297 Cu(I) binding site [ion binding]; other site 395495008298 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495008299 Cu(I) binding site [ion binding]; other site 395495008300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495008301 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 395495008302 Interdomain contacts; other site 395495008303 Cytokine receptor motif; other site 395495008304 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 395495008305 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 395495008306 CAP-like domain; other site 395495008307 active site 395495008308 primary dimer interface [polypeptide binding]; other site 395495008309 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 395495008310 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495008311 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495008312 ligand binding site [chemical binding]; other site 395495008313 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 395495008314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008315 ATP binding site [chemical binding]; other site 395495008316 Mg2+ binding site [ion binding]; other site 395495008317 G-X-G motif; other site 395495008318 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 395495008319 anchoring element; other site 395495008320 dimer interface [polypeptide binding]; other site 395495008321 ATP binding site [chemical binding]; other site 395495008322 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 395495008323 active site 395495008324 metal binding site [ion binding]; metal-binding site 395495008325 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 395495008326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495008327 putative substrate translocation pore; other site 395495008328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495008329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495008330 S-adenosylmethionine binding site [chemical binding]; other site 395495008331 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 395495008332 dihydrodipicolinate synthase; Region: dapA; TIGR00674 395495008333 dimer interface [polypeptide binding]; other site 395495008334 active site 395495008335 catalytic residue [active] 395495008336 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 395495008337 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 395495008338 Cupin superfamily protein; Region: Cupin_4; pfam08007 395495008339 Cupin-like domain; Region: Cupin_8; pfam13621 395495008340 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 395495008341 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395495008342 trimer interface [polypeptide binding]; other site 395495008343 active site 395495008344 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 395495008345 Flavoprotein; Region: Flavoprotein; pfam02441 395495008346 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 395495008347 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 395495008348 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395495008349 N-terminal plug; other site 395495008350 ligand-binding site [chemical binding]; other site 395495008351 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 395495008352 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 395495008353 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395495008354 ATP binding site [chemical binding]; other site 395495008355 Mg++ binding site [ion binding]; other site 395495008356 motif III; other site 395495008357 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495008358 nucleotide binding region [chemical binding]; other site 395495008359 ATP-binding site [chemical binding]; other site 395495008360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495008361 Coenzyme A binding pocket [chemical binding]; other site 395495008362 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 395495008363 hypothetical protein; Validated; Region: PRK02101 395495008364 hypothetical protein; Provisional; Region: PRK01842 395495008365 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 395495008366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395495008367 minor groove reading motif; other site 395495008368 helix-hairpin-helix signature motif; other site 395495008369 substrate binding pocket [chemical binding]; other site 395495008370 active site 395495008371 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395495008372 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 395495008373 intersubunit interface [polypeptide binding]; other site 395495008374 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 395495008375 tetramerization interface [polypeptide binding]; other site 395495008376 active site 395495008377 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 395495008378 cobalamin synthase; Reviewed; Region: cobS; PRK00235 395495008379 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 395495008380 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 395495008381 putative dimer interface [polypeptide binding]; other site 395495008382 active site pocket [active] 395495008383 putative cataytic base [active] 395495008384 cobyric acid synthase; Provisional; Region: PRK00784 395495008385 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495008386 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495008387 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 395495008388 catalytic triad [active] 395495008389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495008390 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 395495008391 Walker A/P-loop; other site 395495008392 ATP binding site [chemical binding]; other site 395495008393 Q-loop/lid; other site 395495008394 ABC transporter signature motif; other site 395495008395 Walker B; other site 395495008396 D-loop; other site 395495008397 H-loop/switch region; other site 395495008398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 395495008399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 395495008400 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395495008401 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 395495008402 intersubunit interface [polypeptide binding]; other site 395495008403 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 395495008404 homotrimer interface [polypeptide binding]; other site 395495008405 Walker A motif; other site 395495008406 GTP binding site [chemical binding]; other site 395495008407 Walker B motif; other site 395495008408 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 395495008409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 395495008410 N-terminal plug; other site 395495008411 ligand-binding site [chemical binding]; other site 395495008412 Cell division protein ZapA; Region: ZapA; pfam05164 395495008413 EVE domain; Region: EVE; cl00728 395495008414 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495008415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008417 metal binding site [ion binding]; metal-binding site 395495008418 active site 395495008419 I-site; other site 395495008420 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 395495008421 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 395495008422 Cysteine-rich domain; Region: CCG; pfam02754 395495008423 Rubrerythrin [Energy production and conversion]; Region: COG1592 395495008424 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 395495008425 binuclear metal center [ion binding]; other site 395495008426 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 395495008427 ANTAR domain; Region: ANTAR; pfam03861 395495008428 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 395495008429 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 395495008430 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 395495008431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495008432 putative substrate translocation pore; other site 395495008433 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395495008434 active site 395495008435 Protein kinase domain; Region: Pkinase; pfam00069 395495008436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495008437 active site 395495008438 ATP binding site [chemical binding]; other site 395495008439 substrate binding site [chemical binding]; other site 395495008440 activation loop (A-loop); other site 395495008441 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 395495008442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495008443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495008444 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495008445 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495008446 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395495008447 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 395495008448 [2Fe-2S] cluster binding site [ion binding]; other site 395495008449 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 395495008450 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 395495008451 [4Fe-4S] binding site [ion binding]; other site 395495008452 molybdopterin cofactor binding site; other site 395495008453 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 395495008454 molybdopterin cofactor binding site; other site 395495008455 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 395495008456 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495008457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008458 active site 395495008459 phosphorylation site [posttranslational modification] 395495008460 intermolecular recognition site; other site 395495008461 dimerization interface [polypeptide binding]; other site 395495008462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495008463 Walker A motif; other site 395495008464 ATP binding site [chemical binding]; other site 395495008465 Walker B motif; other site 395495008466 arginine finger; other site 395495008467 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495008468 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 395495008469 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 395495008470 dimer interface [polypeptide binding]; other site 395495008471 phosphorylation site [posttranslational modification] 395495008472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008473 ATP binding site [chemical binding]; other site 395495008474 Mg2+ binding site [ion binding]; other site 395495008475 G-X-G motif; other site 395495008476 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 395495008477 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 395495008478 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 395495008479 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395495008480 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 395495008481 Walker A/P-loop; other site 395495008482 ATP binding site [chemical binding]; other site 395495008483 Q-loop/lid; other site 395495008484 ABC transporter signature motif; other site 395495008485 Walker B; other site 395495008486 D-loop; other site 395495008487 H-loop/switch region; other site 395495008488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 395495008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495008490 dimer interface [polypeptide binding]; other site 395495008491 conserved gate region; other site 395495008492 putative PBP binding loops; other site 395495008493 ABC-ATPase subunit interface; other site 395495008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495008495 dimer interface [polypeptide binding]; other site 395495008496 conserved gate region; other site 395495008497 putative PBP binding loops; other site 395495008498 ABC-ATPase subunit interface; other site 395495008499 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 395495008500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495008501 substrate binding pocket [chemical binding]; other site 395495008502 membrane-bound complex binding site; other site 395495008503 hinge residues; other site 395495008504 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 395495008505 homodimer interface [polypeptide binding]; other site 395495008506 active site 395495008507 glycosyl transferase family protein; Provisional; Region: PRK08136 395495008508 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395495008509 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 395495008510 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495008511 acyl-activating enzyme (AAE) consensus motif; other site 395495008512 AMP binding site [chemical binding]; other site 395495008513 active site 395495008514 CoA binding site [chemical binding]; other site 395495008515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495008516 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 395495008517 dimer interface [polypeptide binding]; other site 395495008518 substrate binding site [chemical binding]; other site 395495008519 metal binding site [ion binding]; metal-binding site 395495008520 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 395495008521 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395495008522 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 395495008523 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395495008524 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395495008525 carboxyltransferase (CT) interaction site; other site 395495008526 biotinylation site [posttranslational modification]; other site 395495008527 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 395495008528 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 395495008529 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 395495008530 membrane ATPase/protein kinase; Provisional; Region: PRK09435 395495008531 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 395495008532 Walker A; other site 395495008533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395495008534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495008535 Coenzyme A binding pocket [chemical binding]; other site 395495008536 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 395495008537 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 395495008538 active site 395495008539 substrate binding site [chemical binding]; other site 395495008540 coenzyme B12 binding site [chemical binding]; other site 395495008541 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 395495008542 B12 binding site [chemical binding]; other site 395495008543 cobalt ligand [ion binding]; other site 395495008544 Transcriptional regulators [Transcription]; Region: GntR; COG1802 395495008545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495008546 DNA-binding site [nucleotide binding]; DNA binding site 395495008547 FCD domain; Region: FCD; pfam07729 395495008548 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 395495008549 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 395495008550 CoA-ligase; Region: Ligase_CoA; pfam00549 395495008551 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 395495008552 CoA binding domain; Region: CoA_binding; smart00881 395495008553 CoA-ligase; Region: Ligase_CoA; pfam00549 395495008554 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 395495008555 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 395495008556 dimer interface [polypeptide binding]; other site 395495008557 active site 395495008558 citrylCoA binding site [chemical binding]; other site 395495008559 NADH binding [chemical binding]; other site 395495008560 cationic pore residues; other site 395495008561 oxalacetate/citrate binding site [chemical binding]; other site 395495008562 coenzyme A binding site [chemical binding]; other site 395495008563 catalytic triad [active] 395495008564 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 395495008565 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 395495008566 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 395495008567 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 395495008568 L-aspartate oxidase; Provisional; Region: PRK06175 395495008569 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 395495008570 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 395495008571 SdhC subunit interface [polypeptide binding]; other site 395495008572 proximal heme binding site [chemical binding]; other site 395495008573 cardiolipin binding site; other site 395495008574 Iron-sulfur protein interface; other site 395495008575 proximal quinone binding site [chemical binding]; other site 395495008576 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 395495008577 Iron-sulfur protein interface; other site 395495008578 proximal quinone binding site [chemical binding]; other site 395495008579 SdhD (CybS) interface [polypeptide binding]; other site 395495008580 proximal heme binding site [chemical binding]; other site 395495008581 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 395495008582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495008583 DNA-binding site [nucleotide binding]; DNA binding site 395495008584 UTRA domain; Region: UTRA; pfam07702 395495008585 malate dehydrogenase; Provisional; Region: PRK05442 395495008586 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 395495008587 NAD(P) binding site [chemical binding]; other site 395495008588 dimer interface [polypeptide binding]; other site 395495008589 malate binding site [chemical binding]; other site 395495008590 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 395495008591 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 395495008592 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 395495008593 substrate binding site [chemical binding]; other site 395495008594 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 395495008595 substrate binding site [chemical binding]; other site 395495008596 ligand binding site [chemical binding]; other site 395495008597 DNA ligase; Provisional; Region: PRK09125 395495008598 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 395495008599 active site 395495008600 DNA binding site [nucleotide binding] 395495008601 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 395495008602 DNA binding site [nucleotide binding] 395495008603 exonuclease I; Provisional; Region: sbcB; PRK11779 395495008604 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 395495008605 active site 395495008606 catalytic site [active] 395495008607 substrate binding site [chemical binding]; other site 395495008608 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 395495008609 exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014 395495008610 CoA-binding domain; Region: CoA_binding_3; pfam13727 395495008611 Bacterial sugar transferase; Region: Bac_transf; pfam02397 395495008612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008614 metal binding site [ion binding]; metal-binding site 395495008615 active site 395495008616 I-site; other site 395495008617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008618 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008619 active site 395495008620 phosphorylation site [posttranslational modification] 395495008621 intermolecular recognition site; other site 395495008622 PAS fold; Region: PAS; pfam00989 395495008623 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008624 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008625 metal binding site [ion binding]; metal-binding site 395495008626 active site 395495008627 I-site; other site 395495008628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495008629 PAS domain; Region: PAS_9; pfam13426 395495008630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008631 putative active site [active] 395495008632 heme pocket [chemical binding]; other site 395495008633 PAS fold; Region: PAS_4; pfam08448 395495008634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495008635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008636 dimer interface [polypeptide binding]; other site 395495008637 phosphorylation site [posttranslational modification] 395495008638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008639 ATP binding site [chemical binding]; other site 395495008640 Mg2+ binding site [ion binding]; other site 395495008641 G-X-G motif; other site 395495008642 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008644 active site 395495008645 phosphorylation site [posttranslational modification] 395495008646 intermolecular recognition site; other site 395495008647 dimerization interface [polypeptide binding]; other site 395495008648 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008650 active site 395495008651 phosphorylation site [posttranslational modification] 395495008652 intermolecular recognition site; other site 395495008653 dimerization interface [polypeptide binding]; other site 395495008654 Hpt domain; Region: Hpt; pfam01627 395495008655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008656 dimer interface [polypeptide binding]; other site 395495008657 phosphorylation site [posttranslational modification] 395495008658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008659 ATP binding site [chemical binding]; other site 395495008660 Mg2+ binding site [ion binding]; other site 395495008661 G-X-G motif; other site 395495008662 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008664 active site 395495008665 phosphorylation site [posttranslational modification] 395495008666 intermolecular recognition site; other site 395495008667 dimerization interface [polypeptide binding]; other site 395495008668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008669 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 395495008670 putative active site [active] 395495008671 heme pocket [chemical binding]; other site 395495008672 PAS domain; Region: PAS_9; pfam13426 395495008673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008674 PAS domain; Region: PAS_9; pfam13426 395495008675 putative active site [active] 395495008676 heme pocket [chemical binding]; other site 395495008677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 395495008678 Histidine kinase; Region: HisKA_2; pfam07568 395495008679 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 395495008680 Mg2+ binding site [ion binding]; other site 395495008681 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 395495008682 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 395495008683 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 395495008684 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 395495008685 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 395495008686 Rod binding protein; Region: Rod-binding; cl01626 395495008687 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 395495008688 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 395495008689 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 395495008690 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 395495008691 Flagellar L-ring protein; Region: FlgH; pfam02107 395495008692 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 395495008693 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 395495008694 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 395495008695 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 395495008696 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 395495008697 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 395495008698 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 395495008699 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 395495008700 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 395495008701 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 395495008702 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 395495008703 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 395495008704 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 395495008705 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 395495008706 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 395495008707 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 395495008708 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 395495008709 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 395495008710 SAF-like; Region: SAF_2; pfam13144 395495008711 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 395495008712 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 395495008713 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 395495008714 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 395495008715 trimer interface [polypeptide binding]; other site 395495008716 active site 395495008717 Protein of unknown function (DUF962); Region: DUF962; cl01879 395495008718 H-NS histone family; Region: Histone_HNS; pfam00816 395495008719 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 395495008720 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 395495008721 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395495008722 putative NAD(P) binding site [chemical binding]; other site 395495008723 structural Zn binding site [ion binding]; other site 395495008724 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495008725 PAS domain; Region: PAS; smart00091 395495008726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008727 dimer interface [polypeptide binding]; other site 395495008728 phosphorylation site [posttranslational modification] 395495008729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008730 ATP binding site [chemical binding]; other site 395495008731 Mg2+ binding site [ion binding]; other site 395495008732 G-X-G motif; other site 395495008733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495008734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495008735 dimer interface [polypeptide binding]; other site 395495008736 putative CheW interface [polypeptide binding]; other site 395495008737 Response regulator receiver domain; Region: Response_reg; pfam00072 395495008738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495008739 active site 395495008740 phosphorylation site [posttranslational modification] 395495008741 intermolecular recognition site; other site 395495008742 dimerization interface [polypeptide binding]; other site 395495008743 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 395495008744 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 395495008745 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 395495008746 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 395495008747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495008748 catalytic loop [active] 395495008749 iron binding site [ion binding]; other site 395495008750 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 395495008751 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 395495008752 [4Fe-4S] binding site [ion binding]; other site 395495008753 molybdopterin cofactor binding site; other site 395495008754 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 395495008755 molybdopterin cofactor binding site; other site 395495008756 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 395495008757 putative dimer interface [polypeptide binding]; other site 395495008758 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 395495008759 SLBB domain; Region: SLBB; pfam10531 395495008760 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 395495008761 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 395495008762 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 395495008763 putative dimer interface [polypeptide binding]; other site 395495008764 [2Fe-2S] cluster binding site [ion binding]; other site 395495008765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495008766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495008767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395495008768 dimerization interface [polypeptide binding]; other site 395495008769 Domain of unknown function DUF59; Region: DUF59; pfam01883 395495008770 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 395495008771 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 395495008772 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495008773 catalytic loop [active] 395495008774 iron binding site [ion binding]; other site 395495008775 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 395495008776 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 395495008777 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 395495008778 active site 395495008779 HIGH motif; other site 395495008780 KMSKS motif; other site 395495008781 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 395495008782 anticodon binding site; other site 395495008783 tRNA binding surface [nucleotide binding]; other site 395495008784 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 395495008785 dimer interface [polypeptide binding]; other site 395495008786 putative tRNA-binding site [nucleotide binding]; other site 395495008787 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 395495008788 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 395495008789 putative transporter; Provisional; Region: PRK11660 395495008790 Sulfate transporter family; Region: Sulfate_transp; pfam00916 395495008791 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 395495008792 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 395495008793 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 395495008794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008795 PAS domain; Region: PAS_9; pfam13426 395495008796 putative active site [active] 395495008797 heme pocket [chemical binding]; other site 395495008798 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008800 metal binding site [ion binding]; metal-binding site 395495008801 active site 395495008802 I-site; other site 395495008803 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495008804 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 395495008805 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 395495008806 active site 395495008807 PAS fold; Region: PAS; pfam00989 395495008808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008809 putative active site [active] 395495008810 heme pocket [chemical binding]; other site 395495008811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495008812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495008813 metal binding site [ion binding]; metal-binding site 395495008814 active site 395495008815 I-site; other site 395495008816 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 395495008817 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 395495008818 active site 395495008819 nucleophile elbow; other site 395495008820 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 395495008821 Part of AAA domain; Region: AAA_19; pfam13245 395495008822 Family description; Region: UvrD_C_2; pfam13538 395495008823 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 395495008824 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 395495008825 dimerization interface [polypeptide binding]; other site 395495008826 DPS ferroxidase diiron center [ion binding]; other site 395495008827 ion pore; other site 395495008828 isocitrate dehydrogenase; Validated; Region: PRK07362 395495008829 isocitrate dehydrogenase; Reviewed; Region: PRK07006 395495008830 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 395495008831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495008832 FeS/SAM binding site; other site 395495008833 HemN C-terminal domain; Region: HemN_C; pfam06969 395495008834 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 395495008835 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495008836 ligand binding site [chemical binding]; other site 395495008837 flexible hinge region; other site 395495008838 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495008839 putative switch regulator; other site 395495008840 non-specific DNA interactions [nucleotide binding]; other site 395495008841 DNA binding site [nucleotide binding] 395495008842 sequence specific DNA binding site [nucleotide binding]; other site 395495008843 putative cAMP binding site [chemical binding]; other site 395495008844 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 395495008845 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 395495008846 4Fe-4S binding domain; Region: Fer4_5; pfam12801 395495008847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495008848 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 395495008849 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 395495008850 Cytochrome c; Region: Cytochrom_C; pfam00034 395495008851 Cytochrome c; Region: Cytochrom_C; pfam00034 395495008852 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 395495008853 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 395495008854 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 395495008855 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 395495008856 Low-spin heme binding site [chemical binding]; other site 395495008857 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 395495008858 Putative water exit pathway; other site 395495008859 Binuclear center (active site) [active] 395495008860 Putative proton exit pathway; other site 395495008861 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 395495008862 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 395495008863 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 395495008864 metal-binding site [ion binding] 395495008865 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395495008866 Soluble P-type ATPase [General function prediction only]; Region: COG4087 395495008867 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 395495008868 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495008869 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 395495008870 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 395495008871 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 395495008872 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 395495008873 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395495008874 Active Sites [active] 395495008875 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 395495008876 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 395495008877 Active Sites [active] 395495008878 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 395495008879 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 395495008880 CysD dimerization site [polypeptide binding]; other site 395495008881 G1 box; other site 395495008882 putative GEF interaction site [polypeptide binding]; other site 395495008883 GTP/Mg2+ binding site [chemical binding]; other site 395495008884 Switch I region; other site 395495008885 G2 box; other site 395495008886 G3 box; other site 395495008887 Switch II region; other site 395495008888 G4 box; other site 395495008889 G5 box; other site 395495008890 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 395495008891 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 395495008892 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 395495008893 active site 395495008894 SAM binding site [chemical binding]; other site 395495008895 homodimer interface [polypeptide binding]; other site 395495008896 Ferredoxin [Energy production and conversion]; Region: COG1146 395495008897 4Fe-4S binding domain; Region: Fer4; cl02805 395495008898 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 395495008899 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 395495008900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495008901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495008902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495008903 putative active site [active] 395495008904 heme pocket [chemical binding]; other site 395495008905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008906 dimer interface [polypeptide binding]; other site 395495008907 phosphorylation site [posttranslational modification] 395495008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008909 ATP binding site [chemical binding]; other site 395495008910 Mg2+ binding site [ion binding]; other site 395495008911 G-X-G motif; other site 395495008912 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 395495008913 active site 395495008914 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 395495008915 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 395495008916 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 395495008917 NAD binding site [chemical binding]; other site 395495008918 homotetramer interface [polypeptide binding]; other site 395495008919 homodimer interface [polypeptide binding]; other site 395495008920 substrate binding site [chemical binding]; other site 395495008921 active site 395495008922 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 395495008923 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 395495008924 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 395495008925 dimer interaction site [polypeptide binding]; other site 395495008926 substrate-binding tunnel; other site 395495008927 active site 395495008928 catalytic site [active] 395495008929 substrate binding site [chemical binding]; other site 395495008930 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 395495008931 Acetokinase family; Region: Acetate_kinase; cl17229 395495008932 propionate/acetate kinase; Provisional; Region: PRK12379 395495008933 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 395495008934 Catalytic site; other site 395495008935 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 395495008936 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 395495008937 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 395495008938 H-NS histone family; Region: Histone_HNS; pfam00816 395495008939 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495008940 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495008941 active site 395495008942 ATP binding site [chemical binding]; other site 395495008943 substrate binding site [chemical binding]; other site 395495008944 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495008945 activation loop (A-loop); other site 395495008946 HDOD domain; Region: HDOD; pfam08668 395495008947 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395495008948 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495008949 catalytic residues [active] 395495008950 transcription termination factor Rho; Provisional; Region: rho; PRK09376 395495008951 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 395495008952 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 395495008953 RNA binding site [nucleotide binding]; other site 395495008954 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 395495008955 multimer interface [polypeptide binding]; other site 395495008956 Walker A motif; other site 395495008957 ATP binding site [chemical binding]; other site 395495008958 Walker B motif; other site 395495008959 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 395495008960 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 395495008961 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495008962 PAS domain; Region: PAS; smart00091 395495008963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495008964 dimer interface [polypeptide binding]; other site 395495008965 phosphorylation site [posttranslational modification] 395495008966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495008967 ATP binding site [chemical binding]; other site 395495008968 Mg2+ binding site [ion binding]; other site 395495008969 G-X-G motif; other site 395495008970 transcriptional regulator PhoU; Provisional; Region: PRK11115 395495008971 PhoU domain; Region: PhoU; pfam01895 395495008972 PhoU domain; Region: PhoU; pfam01895 395495008973 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 395495008974 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 395495008975 Walker A/P-loop; other site 395495008976 ATP binding site [chemical binding]; other site 395495008977 Q-loop/lid; other site 395495008978 ABC transporter signature motif; other site 395495008979 Walker B; other site 395495008980 D-loop; other site 395495008981 H-loop/switch region; other site 395495008982 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 395495008983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495008984 dimer interface [polypeptide binding]; other site 395495008985 conserved gate region; other site 395495008986 putative PBP binding loops; other site 395495008987 ABC-ATPase subunit interface; other site 395495008988 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 395495008989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495008990 dimer interface [polypeptide binding]; other site 395495008991 conserved gate region; other site 395495008992 putative PBP binding loops; other site 395495008993 ABC-ATPase subunit interface; other site 395495008994 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495008995 substrate binding pocket [chemical binding]; other site 395495008996 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 395495008997 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 395495008998 active site 395495008999 substrate binding site [chemical binding]; other site 395495009000 metal binding site [ion binding]; metal-binding site 395495009001 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 395495009002 dihydropteroate synthase; Region: DHPS; TIGR01496 395495009003 substrate binding pocket [chemical binding]; other site 395495009004 dimer interface [polypeptide binding]; other site 395495009005 inhibitor binding site; inhibition site 395495009006 FtsH Extracellular; Region: FtsH_ext; pfam06480 395495009007 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 395495009008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009009 Walker A motif; other site 395495009010 ATP binding site [chemical binding]; other site 395495009011 Walker B motif; other site 395495009012 arginine finger; other site 395495009013 Peptidase family M41; Region: Peptidase_M41; pfam01434 395495009014 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 395495009015 FtsJ-like methyltransferase; Region: FtsJ; cl17430 395495009016 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 395495009017 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 395495009018 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 395495009019 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 395495009020 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 395495009021 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395495009022 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 395495009023 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 395495009024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395495009025 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495009026 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 395495009027 IMP binding site; other site 395495009028 dimer interface [polypeptide binding]; other site 395495009029 interdomain contacts; other site 395495009030 partial ornithine binding site; other site 395495009031 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 395495009032 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 395495009033 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 395495009034 catalytic site [active] 395495009035 subunit interface [polypeptide binding]; other site 395495009036 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 395495009037 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 395495009038 YccA-like proteins; Region: YccA_like; cd10433 395495009039 replicative DNA helicase; Region: DnaB; TIGR00665 395495009040 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 395495009041 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 395495009042 Walker A motif; other site 395495009043 ATP binding site [chemical binding]; other site 395495009044 Walker B motif; other site 395495009045 DNA binding loops [nucleotide binding] 395495009046 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 395495009047 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 395495009048 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 395495009049 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 395495009050 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 395495009051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 395495009052 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 395495009053 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 395495009054 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 395495009055 phosphoenolpyruvate synthase; Validated; Region: PRK06464 395495009056 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 395495009057 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 395495009058 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 395495009059 PEP synthetase regulatory protein; Provisional; Region: PRK05339 395495009060 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 395495009061 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 395495009062 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 395495009063 RNA/DNA hybrid binding site [nucleotide binding]; other site 395495009064 active site 395495009065 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 395495009066 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 395495009067 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 395495009068 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 395495009069 active site 395495009070 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 395495009071 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 395495009072 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 395495009073 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 395495009074 trimer interface [polypeptide binding]; other site 395495009075 active site 395495009076 UDP-GlcNAc binding site [chemical binding]; other site 395495009077 lipid binding site [chemical binding]; lipid-binding site 395495009078 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 395495009079 periplasmic chaperone; Provisional; Region: PRK10780 395495009080 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 395495009081 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009082 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009083 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009084 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009085 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009086 Surface antigen; Region: Bac_surface_Ag; pfam01103 395495009087 zinc metallopeptidase RseP; Provisional; Region: PRK10779 395495009088 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 395495009089 active site 395495009090 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 395495009091 putative substrate binding region [chemical binding]; other site 395495009092 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 395495009093 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 395495009094 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 395495009095 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 395495009096 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 395495009097 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 395495009098 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 395495009099 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 395495009100 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 395495009101 catalytic residue [active] 395495009102 putative FPP diphosphate binding site; other site 395495009103 putative FPP binding hydrophobic cleft; other site 395495009104 dimer interface [polypeptide binding]; other site 395495009105 putative IPP diphosphate binding site; other site 395495009106 ribosome recycling factor; Reviewed; Region: frr; PRK00083 395495009107 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 395495009108 hinge region; other site 395495009109 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 395495009110 putative nucleotide binding site [chemical binding]; other site 395495009111 uridine monophosphate binding site [chemical binding]; other site 395495009112 homohexameric interface [polypeptide binding]; other site 395495009113 elongation factor Ts; Provisional; Region: tsf; PRK09377 395495009114 UBA/TS-N domain; Region: UBA; pfam00627 395495009115 Elongation factor TS; Region: EF_TS; pfam00889 395495009116 Elongation factor TS; Region: EF_TS; pfam00889 395495009117 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 395495009118 rRNA interaction site [nucleotide binding]; other site 395495009119 S8 interaction site; other site 395495009120 putative laminin-1 binding site; other site 395495009121 Amidase; Region: Amidase; cl11426 395495009122 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 395495009123 PIN domain; Region: PIN_3; pfam13470 395495009124 Uncharacterized conserved protein [Function unknown]; Region: COG0062 395495009125 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 395495009126 putative substrate binding site [chemical binding]; other site 395495009127 putative ATP binding site [chemical binding]; other site 395495009128 ribonuclease R; Region: RNase_R; TIGR02063 395495009129 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 395495009130 RNB domain; Region: RNB; pfam00773 395495009131 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 395495009132 RNA binding site [nucleotide binding]; other site 395495009133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495009134 active site 395495009135 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 395495009136 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 395495009137 GDP-binding site [chemical binding]; other site 395495009138 ACT binding site; other site 395495009139 IMP binding site; other site 395495009140 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 395495009141 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 395495009142 dimer interface [polypeptide binding]; other site 395495009143 motif 1; other site 395495009144 active site 395495009145 motif 2; other site 395495009146 motif 3; other site 395495009147 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 395495009148 HflC protein; Region: hflC; TIGR01932 395495009149 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 395495009150 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 395495009151 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 395495009152 HflK protein; Region: hflK; TIGR01933 395495009153 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 395495009154 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 395495009155 HflX GTPase family; Region: HflX; cd01878 395495009156 G1 box; other site 395495009157 GTP/Mg2+ binding site [chemical binding]; other site 395495009158 Switch I region; other site 395495009159 G2 box; other site 395495009160 G3 box; other site 395495009161 Switch II region; other site 395495009162 G4 box; other site 395495009163 G5 box; other site 395495009164 bacterial Hfq-like; Region: Hfq; cd01716 395495009165 hexamer interface [polypeptide binding]; other site 395495009166 Sm1 motif; other site 395495009167 RNA binding site [nucleotide binding]; other site 395495009168 Sm2 motif; other site 395495009169 GTP-binding protein Der; Reviewed; Region: PRK00093 395495009170 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 395495009171 G1 box; other site 395495009172 GTP/Mg2+ binding site [chemical binding]; other site 395495009173 Switch I region; other site 395495009174 G2 box; other site 395495009175 Switch II region; other site 395495009176 G3 box; other site 395495009177 G4 box; other site 395495009178 G5 box; other site 395495009179 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 395495009180 G1 box; other site 395495009181 GTP/Mg2+ binding site [chemical binding]; other site 395495009182 Switch I region; other site 395495009183 G2 box; other site 395495009184 G3 box; other site 395495009185 Switch II region; other site 395495009186 G4 box; other site 395495009187 G5 box; other site 395495009188 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 395495009189 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 395495009190 Trp docking motif [polypeptide binding]; other site 395495009191 active site 395495009192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 395495009193 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 395495009194 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 395495009195 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 395495009196 dimer interface [polypeptide binding]; other site 395495009197 motif 1; other site 395495009198 active site 395495009199 motif 2; other site 395495009200 motif 3; other site 395495009201 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 395495009202 anticodon binding site; other site 395495009203 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 395495009204 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395495009205 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 395495009206 Helix-turn-helix domain; Region: HTH_25; pfam13413 395495009207 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 395495009208 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 395495009209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495009210 binding surface 395495009211 TPR motif; other site 395495009212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395495009213 binding surface 395495009214 TPR motif; other site 395495009215 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 395495009216 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 395495009217 active site 395495009218 multimer interface [polypeptide binding]; other site 395495009219 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 395495009220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495009221 RNA binding surface [nucleotide binding]; other site 395495009222 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 395495009223 probable active site [active] 395495009224 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 395495009225 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395495009226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495009227 RNA binding surface [nucleotide binding]; other site 395495009228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 395495009229 active site 395495009230 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 395495009231 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 395495009232 DEAD/DEAH box helicase; Region: DEAD; pfam00270 395495009233 ATP binding site [chemical binding]; other site 395495009234 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 395495009235 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 395495009236 active site 395495009237 Predicted ATPase [General function prediction only]; Region: COG1485 395495009238 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 395495009239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495009240 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 395495009241 Short C-terminal domain; Region: SHOCT; pfam09851 395495009242 PspC domain; Region: PspC; pfam04024 395495009243 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 395495009244 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 395495009245 E3 interaction surface; other site 395495009246 lipoyl attachment site [posttranslational modification]; other site 395495009247 e3 binding domain; Region: E3_binding; pfam02817 395495009248 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 395495009249 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 395495009250 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 395495009251 TPP-binding site [chemical binding]; other site 395495009252 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 395495009253 TIGR03790 family protein; Region: TIGR03790 395495009254 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495009255 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395495009256 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495009257 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 395495009258 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 395495009259 2-isopropylmalate synthase; Validated; Region: PRK00915 395495009260 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 395495009261 active site 395495009262 catalytic residues [active] 395495009263 metal binding site [ion binding]; metal-binding site 395495009264 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 395495009265 2-isopropylmalate synthase; Validated; Region: PRK03739 395495009266 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 395495009267 active site 395495009268 catalytic residues [active] 395495009269 metal binding site [ion binding]; metal-binding site 395495009270 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 395495009271 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 395495009272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 395495009273 ketol-acid reductoisomerase; Provisional; Region: PRK05479 395495009274 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 395495009275 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 395495009276 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 395495009277 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 395495009278 putative valine binding site [chemical binding]; other site 395495009279 dimer interface [polypeptide binding]; other site 395495009280 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 395495009281 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 395495009282 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395495009283 PYR/PP interface [polypeptide binding]; other site 395495009284 dimer interface [polypeptide binding]; other site 395495009285 TPP binding site [chemical binding]; other site 395495009286 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395495009287 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 395495009288 TPP-binding site [chemical binding]; other site 395495009289 dimer interface [polypeptide binding]; other site 395495009290 RNA polymerase factor sigma-70; Validated; Region: PRK09047 395495009291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495009292 DNA binding residues [nucleotide binding] 395495009293 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 395495009294 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 395495009295 RDD family; Region: RDD; pfam06271 395495009296 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 395495009297 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 395495009298 Nitrogen regulatory protein P-II; Region: P-II; smart00938 395495009299 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 395495009300 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495009301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495009302 ABC transporter; Region: ABC_tran_2; pfam12848 395495009303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495009304 Uncharacterized conserved protein [Function unknown]; Region: COG4544 395495009305 Y-family of DNA polymerases; Region: PolY; cl12025 395495009306 DNA binding site [nucleotide binding] 395495009307 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 395495009308 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 395495009309 putative active site [active] 395495009310 putative PHP Thumb interface [polypeptide binding]; other site 395495009311 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 395495009312 generic binding surface II; other site 395495009313 generic binding surface I; other site 395495009314 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 395495009315 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 395495009316 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495009317 Type II transport protein GspH; Region: GspH; pfam12019 395495009318 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 395495009319 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 395495009320 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 395495009321 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 395495009322 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 395495009323 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 395495009324 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 395495009325 putative active site [active] 395495009326 Zn binding site [ion binding]; other site 395495009327 MoxR-like ATPases [General function prediction only]; Region: COG0714 395495009328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009329 Walker A motif; other site 395495009330 ATP binding site [chemical binding]; other site 395495009331 Walker B motif; other site 395495009332 arginine finger; other site 395495009333 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 395495009334 Protein of unknown function DUF58; Region: DUF58; pfam01882 395495009335 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 395495009336 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 395495009337 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 395495009338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495009339 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 395495009340 dimer interface [polypeptide binding]; other site 395495009341 active site 395495009342 metal binding site [ion binding]; metal-binding site 395495009343 glutathione binding site [chemical binding]; other site 395495009344 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 395495009345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495009346 ATP binding site [chemical binding]; other site 395495009347 putative Mg++ binding site [ion binding]; other site 395495009348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495009349 nucleotide binding region [chemical binding]; other site 395495009350 ATP-binding site [chemical binding]; other site 395495009351 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 395495009352 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495009353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495009354 Walker A/P-loop; other site 395495009355 ATP binding site [chemical binding]; other site 395495009356 Q-loop/lid; other site 395495009357 ABC transporter signature motif; other site 395495009358 Walker B; other site 395495009359 D-loop; other site 395495009360 H-loop/switch region; other site 395495009361 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 395495009362 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 395495009363 active site 395495009364 intersubunit interface [polypeptide binding]; other site 395495009365 catalytic residue [active] 395495009366 phosphogluconate dehydratase; Validated; Region: PRK09054 395495009367 6-phosphogluconate dehydratase; Region: edd; TIGR01196 395495009368 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 395495009369 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 395495009370 putative active site pocket [active] 395495009371 dimerization interface [polypeptide binding]; other site 395495009372 putative catalytic residue [active] 395495009373 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 395495009374 Ligand binding site; other site 395495009375 metal-binding site 395495009376 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 395495009377 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 395495009378 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 395495009379 methionine sulfoxide reductase A; Provisional; Region: PRK14054 395495009380 Uncharacterized conserved protein [Function unknown]; Region: COG1434 395495009381 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 395495009382 putative active site [active] 395495009383 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 395495009384 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 395495009385 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 395495009386 N-acetyl-D-glucosamine binding site [chemical binding]; other site 395495009387 catalytic residue [active] 395495009388 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 395495009389 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 395495009390 dimer interface [polypeptide binding]; other site 395495009391 active site 395495009392 glycine-pyridoxal phosphate binding site [chemical binding]; other site 395495009393 folate binding site [chemical binding]; other site 395495009394 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 395495009395 ATP cone domain; Region: ATP-cone; pfam03477 395495009396 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 395495009397 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 395495009398 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 395495009399 hypothetical protein; Provisional; Region: PRK10557 395495009400 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 395495009401 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 395495009402 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 395495009403 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 395495009404 catalytic motif [active] 395495009405 Zn binding site [ion binding]; other site 395495009406 RibD C-terminal domain; Region: RibD_C; cl17279 395495009407 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 395495009408 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 395495009409 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 395495009410 dimerization interface [polypeptide binding]; other site 395495009411 active site 395495009412 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 395495009413 homopentamer interface [polypeptide binding]; other site 395495009414 active site 395495009415 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 395495009416 aminotransferase; Validated; Region: PRK07337 395495009417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495009418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495009419 homodimer interface [polypeptide binding]; other site 395495009420 catalytic residue [active] 395495009421 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495009422 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395495009423 active site 395495009424 ATP binding site [chemical binding]; other site 395495009425 substrate binding site [chemical binding]; other site 395495009426 activation loop (A-loop); other site 395495009427 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 395495009428 active site 395495009429 TolQ protein; Region: tolQ; TIGR02796 395495009430 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495009431 TolR protein; Region: tolR; TIGR02801 395495009432 TonB C terminal; Region: TonB_2; pfam13103 395495009433 TolA protein; Region: tolA_full; TIGR02794 395495009434 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 395495009435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495009436 Zn2+ binding site [ion binding]; other site 395495009437 Mg2+ binding site [ion binding]; other site 395495009438 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 395495009439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395495009440 PAS domain; Region: PAS_9; pfam13426 395495009441 putative active site [active] 395495009442 heme pocket [chemical binding]; other site 395495009443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495009444 metal binding site [ion binding]; metal-binding site 395495009445 active site 395495009446 I-site; other site 395495009447 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495009448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495009449 Coenzyme A binding pocket [chemical binding]; other site 395495009450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495009451 active site 395495009452 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 395495009453 protein binding site [polypeptide binding]; other site 395495009454 Predicted permeases [General function prediction only]; Region: RarD; COG2962 395495009455 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 395495009456 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395495009457 oligomeric interface; other site 395495009458 putative active site [active] 395495009459 homodimer interface [polypeptide binding]; other site 395495009460 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 395495009461 Protein of unknown function DUF262; Region: DUF262; pfam03235 395495009462 Uncharacterized conserved protein [Function unknown]; Region: COG1479 395495009463 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 395495009464 dimer interface [polypeptide binding]; other site 395495009465 FOG: CBS domain [General function prediction only]; Region: COG0517 395495009466 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 395495009467 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395495009468 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 395495009469 putative C-terminal domain interface [polypeptide binding]; other site 395495009470 putative GSH binding site (G-site) [chemical binding]; other site 395495009471 putative dimer interface [polypeptide binding]; other site 395495009472 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 395495009473 dimer interface [polypeptide binding]; other site 395495009474 N-terminal domain interface [polypeptide binding]; other site 395495009475 putative substrate binding pocket (H-site) [chemical binding]; other site 395495009476 Nuclease-related domain; Region: NERD; pfam08378 395495009477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395495009478 ATP binding site [chemical binding]; other site 395495009479 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 395495009480 putative Mg++ binding site [ion binding]; other site 395495009481 Family description; Region: UvrD_C_2; pfam13538 395495009482 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 395495009483 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 395495009484 active site 395495009485 substrate binding site [chemical binding]; other site 395495009486 Mg2+ binding site [ion binding]; other site 395495009487 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 395495009488 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 395495009489 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 395495009490 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 395495009491 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 395495009492 active site 395495009493 HAMP domain; Region: HAMP; pfam00672 395495009494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495009495 dimer interface [polypeptide binding]; other site 395495009496 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 395495009497 putative CheW interface [polypeptide binding]; other site 395495009498 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 395495009499 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 395495009500 active site 395495009501 NAD synthetase; Provisional; Region: PRK13981 395495009502 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 395495009503 multimer interface [polypeptide binding]; other site 395495009504 active site 395495009505 catalytic triad [active] 395495009506 protein interface 1 [polypeptide binding]; other site 395495009507 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 395495009508 homodimer interface [polypeptide binding]; other site 395495009509 NAD binding pocket [chemical binding]; other site 395495009510 ATP binding pocket [chemical binding]; other site 395495009511 Mg binding site [ion binding]; other site 395495009512 active-site loop [active] 395495009513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 395495009514 Protein of unknown function, DUF482; Region: DUF482; pfam04339 395495009515 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 395495009516 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 395495009517 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 395495009518 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 395495009519 dimer interface [polypeptide binding]; other site 395495009520 substrate binding site [chemical binding]; other site 395495009521 metal binding sites [ion binding]; metal-binding site 395495009522 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 395495009523 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 395495009524 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 395495009525 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 395495009526 ferredoxin; Provisional; Region: PRK08764 395495009527 Putative Fe-S cluster; Region: FeS; pfam04060 395495009528 4Fe-4S binding domain; Region: Fer4; pfam00037 395495009529 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 395495009530 integrase; Provisional; Region: PRK09692 395495009531 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 395495009532 active site 395495009533 Int/Topo IB signature motif; other site 395495009534 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 395495009535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 395495009536 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 395495009537 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 395495009538 Hsp70 protein; Region: HSP70; pfam00012 395495009539 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 395495009540 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 395495009541 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 395495009542 tartrate dehydrogenase; Region: TTC; TIGR02089 395495009543 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 395495009544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495009545 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 395495009546 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 395495009547 Isochorismatase family; Region: Isochorismatase; pfam00857 395495009548 catalytic triad [active] 395495009549 dimer interface [polypeptide binding]; other site 395495009550 conserved cis-peptide bond; other site 395495009551 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 395495009552 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 395495009553 ATP binding site [chemical binding]; other site 395495009554 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 395495009555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495009556 ATP binding site [chemical binding]; other site 395495009557 putative Mg++ binding site [ion binding]; other site 395495009558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495009559 nucleotide binding region [chemical binding]; other site 395495009560 ATP-binding site [chemical binding]; other site 395495009561 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 395495009562 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 395495009563 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395495009564 ATP binding site [chemical binding]; other site 395495009565 Mg++ binding site [ion binding]; other site 395495009566 motif III; other site 395495009567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495009568 nucleotide binding region [chemical binding]; other site 395495009569 ATP-binding site [chemical binding]; other site 395495009570 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 395495009571 putative RNA binding site [nucleotide binding]; other site 395495009572 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 395495009573 putative active site [active] 395495009574 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 395495009575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495009576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495009577 Walker A/P-loop; other site 395495009578 ATP binding site [chemical binding]; other site 395495009579 Q-loop/lid; other site 395495009580 ABC transporter signature motif; other site 395495009581 Walker B; other site 395495009582 D-loop; other site 395495009583 H-loop/switch region; other site 395495009584 Winged helix-turn helix; Region: HTH_29; pfam13551 395495009585 Homeodomain-like domain; Region: HTH_32; pfam13565 395495009586 Integrase core domain; Region: rve; pfam00665 395495009587 DDE domain; Region: DDE_Tnp_IS240; pfam13610 395495009588 Integrase core domain; Region: rve_3; pfam13683 395495009589 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 395495009590 Helix-turn-helix domain; Region: HTH_38; pfam13936 395495009591 Integrase core domain; Region: rve; pfam00665 395495009592 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 395495009593 Helix-turn-helix domain; Region: HTH_38; pfam13936 395495009594 Integrase core domain; Region: rve; pfam00665 395495009595 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 395495009596 FAD binding domain; Region: FAD_binding_4; pfam01565 395495009597 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 395495009598 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395495009599 FMN binding site [chemical binding]; other site 395495009600 substrate binding site [chemical binding]; other site 395495009601 putative catalytic residue [active] 395495009602 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 395495009603 Dihaem cytochrome c; Region: DHC; pfam09626 395495009604 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 395495009605 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 395495009606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495009607 active site 395495009608 phosphorylation site [posttranslational modification] 395495009609 intermolecular recognition site; other site 395495009610 dimerization interface [polypeptide binding]; other site 395495009611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495009612 DNA binding site [nucleotide binding] 395495009613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495009614 dimer interface [polypeptide binding]; other site 395495009615 phosphorylation site [posttranslational modification] 395495009616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495009617 ATP binding site [chemical binding]; other site 395495009618 Mg2+ binding site [ion binding]; other site 395495009619 G-X-G motif; other site 395495009620 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 395495009621 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 395495009622 putative active site [active] 395495009623 putative metal binding site [ion binding]; other site 395495009624 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 395495009625 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 395495009626 homodimer interface [polypeptide binding]; other site 395495009627 substrate-cofactor binding pocket; other site 395495009628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495009629 catalytic residue [active] 395495009630 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 395495009631 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395495009632 putative ligand binding site [chemical binding]; other site 395495009633 putative NAD binding site [chemical binding]; other site 395495009634 putative catalytic site [active] 395495009635 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 395495009636 L-serine binding site [chemical binding]; other site 395495009637 ACT domain interface; other site 395495009638 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 395495009639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495009640 dimerization interface [polypeptide binding]; other site 395495009641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009642 PAS domain; Region: PAS_9; pfam13426 395495009643 putative active site [active] 395495009644 heme pocket [chemical binding]; other site 395495009645 PAS domain; Region: PAS_9; pfam13426 395495009646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009647 putative active site [active] 395495009648 heme pocket [chemical binding]; other site 395495009649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009650 PAS domain; Region: PAS_9; pfam13426 395495009651 putative active site [active] 395495009652 heme pocket [chemical binding]; other site 395495009653 PAS fold; Region: PAS_4; pfam08448 395495009654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009655 putative active site [active] 395495009656 heme pocket [chemical binding]; other site 395495009657 PAS fold; Region: PAS_4; pfam08448 395495009658 PAS fold; Region: PAS_3; pfam08447 395495009659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009660 putative active site [active] 395495009661 heme pocket [chemical binding]; other site 395495009662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495009663 PAS domain; Region: PAS_9; pfam13426 395495009664 putative active site [active] 395495009665 heme pocket [chemical binding]; other site 395495009666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495009667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495009668 metal binding site [ion binding]; metal-binding site 395495009669 active site 395495009670 I-site; other site 395495009671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495009672 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 395495009673 Transcriptional regulators [Transcription]; Region: GntR; COG1802 395495009674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495009675 DNA-binding site [nucleotide binding]; DNA binding site 395495009676 FCD domain; Region: FCD; pfam07729 395495009677 Isochorismatase family; Region: Isochorismatase; pfam00857 395495009678 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 395495009679 catalytic triad [active] 395495009680 conserved cis-peptide bond; other site 395495009681 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 395495009682 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495009683 Walker A/P-loop; other site 395495009684 ATP binding site [chemical binding]; other site 395495009685 Q-loop/lid; other site 395495009686 ABC transporter signature motif; other site 395495009687 Walker B; other site 395495009688 D-loop; other site 395495009689 H-loop/switch region; other site 395495009690 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495009691 Isochorismatase family; Region: Isochorismatase; pfam00857 395495009692 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 395495009693 catalytic triad [active] 395495009694 conserved cis-peptide bond; other site 395495009695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495009696 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495009697 TM-ABC transporter signature motif; other site 395495009698 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495009699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495009700 TM-ABC transporter signature motif; other site 395495009701 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 395495009702 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 395495009703 putative ligand binding site [chemical binding]; other site 395495009704 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 395495009705 amidase; Provisional; Region: PRK09201 395495009706 Amidase; Region: Amidase; pfam01425 395495009707 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 395495009708 allophanate hydrolase; Provisional; Region: PRK08186 395495009709 Amidase; Region: Amidase; cl11426 395495009710 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 395495009711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009712 Walker A motif; other site 395495009713 ATP binding site [chemical binding]; other site 395495009714 Walker B motif; other site 395495009715 arginine finger; other site 395495009716 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 395495009717 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 395495009718 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 395495009719 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 395495009720 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 395495009721 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 395495009722 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 395495009723 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 395495009724 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 395495009725 phage tail protein domain; Region: tail_TIGR02242 395495009726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009727 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495009728 Walker A motif; other site 395495009729 ATP binding site [chemical binding]; other site 395495009730 Walker B motif; other site 395495009731 arginine finger; other site 395495009732 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 395495009733 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495009734 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495009735 ligand binding site [chemical binding]; other site 395495009736 sodium/calcium exchanger 1; Region: caca; TIGR00845 395495009737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495009738 putative substrate translocation pore; other site 395495009739 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395495009740 putative acyl-acceptor binding pocket; other site 395495009741 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 395495009742 yiaA/B two helix domain; Region: YiaAB; cl01759 395495009743 yiaA/B two helix domain; Region: YiaAB; cl01759 395495009744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395495009745 non-specific DNA binding site [nucleotide binding]; other site 395495009746 salt bridge; other site 395495009747 sequence-specific DNA binding site [nucleotide binding]; other site 395495009748 acetyl-CoA synthetase; Provisional; Region: PRK00174 395495009749 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 395495009750 active site 395495009751 CoA binding site [chemical binding]; other site 395495009752 acyl-activating enzyme (AAE) consensus motif; other site 395495009753 AMP binding site [chemical binding]; other site 395495009754 acetate binding site [chemical binding]; other site 395495009755 hypothetical protein; Provisional; Region: PRK05208 395495009756 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 395495009757 Fumarase C-terminus; Region: Fumerase_C; pfam05683 395495009758 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 395495009759 Mechanosensitive ion channel; Region: MS_channel; pfam00924 395495009760 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395495009761 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 395495009762 active site 395495009763 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 395495009764 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 395495009765 NAD binding site [chemical binding]; other site 395495009766 substrate binding site [chemical binding]; other site 395495009767 homodimer interface [polypeptide binding]; other site 395495009768 active site 395495009769 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 395495009770 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 395495009771 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 395495009772 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 395495009773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 395495009774 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 395495009775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 395495009776 Predicted membrane protein [Function unknown]; Region: COG4763 395495009777 Acyltransferase family; Region: Acyl_transf_3; pfam01757 395495009778 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 395495009779 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 395495009780 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 395495009781 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 395495009782 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 395495009783 putative active site [active] 395495009784 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 395495009785 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 395495009786 DXD motif; other site 395495009787 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 395495009788 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 395495009789 putative active site [active] 395495009790 putative metal binding site [ion binding]; other site 395495009791 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 395495009792 O-Antigen ligase; Region: Wzy_C; pfam04932 395495009793 O-Antigen ligase; Region: Wzy_C; pfam04932 395495009794 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 395495009795 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 395495009796 putative NAD(P) binding site [chemical binding]; other site 395495009797 active site 395495009798 putative substrate binding site [chemical binding]; other site 395495009799 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495009800 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 395495009801 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 395495009802 putative active site [active] 395495009803 putative catalytic site [active] 395495009804 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 395495009805 putative ADP-binding pocket [chemical binding]; other site 395495009806 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 395495009807 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 395495009808 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 395495009809 putative ADP-binding pocket [chemical binding]; other site 395495009810 Uncharacterized conserved protein [Function unknown]; Region: COG1434 395495009811 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 395495009812 putative active site [active] 395495009813 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 395495009814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495009815 active site 395495009816 phosphorylation site [posttranslational modification] 395495009817 intermolecular recognition site; other site 395495009818 dimerization interface [polypeptide binding]; other site 395495009819 LytTr DNA-binding domain; Region: LytTR; smart00850 395495009820 Histidine kinase; Region: His_kinase; pfam06580 395495009821 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 395495009822 ATP binding site [chemical binding]; other site 395495009823 Mg2+ binding site [ion binding]; other site 395495009824 G-X-G motif; other site 395495009825 argininosuccinate lyase; Provisional; Region: PRK00855 395495009826 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 395495009827 active sites [active] 395495009828 tetramer interface [polypeptide binding]; other site 395495009829 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 395495009830 Secretin and TonB N terminus short domain; Region: STN; pfam07660 395495009831 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 395495009832 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 395495009833 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495009834 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495009835 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 395495009836 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395495009837 Walker A motif; other site 395495009838 ATP binding site [chemical binding]; other site 395495009839 Walker B motif; other site 395495009840 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 395495009841 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495009842 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495009843 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 395495009844 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 395495009845 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495009846 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 395495009847 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 395495009848 Trp docking motif [polypeptide binding]; other site 395495009849 dimer interface [polypeptide binding]; other site 395495009850 active site 395495009851 small subunit binding site [polypeptide binding]; other site 395495009852 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 395495009853 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 395495009854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495009855 substrate binding pocket [chemical binding]; other site 395495009856 membrane-bound complex binding site; other site 395495009857 hinge residues; other site 395495009858 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 395495009859 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 395495009860 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 395495009861 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 395495009862 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495009863 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495009864 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495009865 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495009866 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 395495009867 putative hydrophobic ligand binding site [chemical binding]; other site 395495009868 protein interface [polypeptide binding]; other site 395495009869 gate; other site 395495009870 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 395495009871 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 395495009872 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 395495009873 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 395495009874 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 395495009875 arsenical-resistance protein; Region: acr3; TIGR00832 395495009876 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 395495009877 Low molecular weight phosphatase family; Region: LMWPc; cd00115 395495009878 active site 395495009879 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 395495009880 putative metal binding site [ion binding]; other site 395495009881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395495009882 putative DNA binding site [nucleotide binding]; other site 395495009883 putative Zn2+ binding site [ion binding]; other site 395495009884 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 395495009885 Interdomain contacts; other site 395495009886 Cytokine receptor motif; other site 395495009887 Transposase domain (DUF772); Region: DUF772; pfam05598 395495009888 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 395495009889 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 395495009890 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 395495009891 Transposase; Region: DEDD_Tnp_IS110; pfam01548 395495009892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 395495009893 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495009894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495009895 active site 395495009896 phosphorylation site [posttranslational modification] 395495009897 intermolecular recognition site; other site 395495009898 Transposase; Region: HTH_Tnp_1; cl17663 395495009899 Homeodomain-like domain; Region: HTH_32; pfam13565 395495009900 Integrase core domain; Region: rve; pfam00665 395495009901 DDE domain; Region: DDE_Tnp_IS240; pfam13610 395495009902 Integrase core domain; Region: rve_3; pfam13683 395495009903 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 395495009904 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 395495009905 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 395495009906 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 395495009907 domain_subunit interface; other site 395495009908 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 395495009909 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 395495009910 FTR, proximal lobe; Region: FTR_C; pfam02741 395495009911 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 395495009912 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395495009913 active site 395495009914 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 395495009915 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 395495009916 molybdopterin cofactor binding site; other site 395495009917 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395495009918 phosphate binding site [ion binding]; other site 395495009919 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495009920 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 395495009921 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 395495009922 nucleotide binding site [chemical binding]; other site 395495009923 substrate binding site [chemical binding]; other site 395495009924 hypothetical protein; Provisional; Region: PRK02227 395495009925 Protein of unknown function (DUF447); Region: DUF447; pfam04289 395495009926 dihydropteroate synthase-related protein; Region: TIGR00284 395495009927 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 395495009928 substrate binding pocket [chemical binding]; other site 395495009929 dimer interface [polypeptide binding]; other site 395495009930 inhibitor binding site; inhibition site 395495009931 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 395495009932 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 395495009933 Flavoprotein; Region: Flavoprotein; cl08021 395495009934 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 395495009935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009936 Walker A motif; other site 395495009937 ATP binding site [chemical binding]; other site 395495009938 Walker B motif; other site 395495009939 arginine finger; other site 395495009940 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495009941 Dihydroneopterin aldolase; Region: FolB; smart00905 395495009942 active site 395495009943 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 395495009944 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 395495009945 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 395495009946 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495009947 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 395495009948 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 395495009949 trimer interface I [polypeptide binding]; other site 395495009950 putative substrate binding pocket [chemical binding]; other site 395495009951 trimer interface II [polypeptide binding]; other site 395495009952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495009953 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 395495009954 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 395495009955 NAD(P) binding pocket [chemical binding]; other site 395495009956 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 395495009957 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395495009958 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 395495009959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495009960 Coenzyme A binding pocket [chemical binding]; other site 395495009961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495009962 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495009963 Walker A motif; other site 395495009964 ATP binding site [chemical binding]; other site 395495009965 Walker B motif; other site 395495009966 arginine finger; other site 395495009967 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 395495009968 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 395495009969 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 395495009970 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395495009971 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 395495009972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 395495009973 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 395495009974 Surface antigen; Region: Bac_surface_Ag; pfam01103 395495009975 Family of unknown function (DUF490); Region: DUF490; pfam04357 395495009976 integrase; Provisional; Region: PRK09692 395495009977 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 395495009978 active site 395495009979 Int/Topo IB signature motif; other site 395495009980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495009981 Transposase; Region: HTH_Tnp_1; pfam01527 395495009982 putative transposase OrfB; Reviewed; Region: PHA02517 395495009983 Integrase core domain; Region: rve; pfam00665 395495009984 Integrase core domain; Region: rve_3; pfam13683 395495009985 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 395495009986 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 395495009987 multiple promoter invertase; Provisional; Region: mpi; PRK13413 395495009988 catalytic residues [active] 395495009989 catalytic nucleophile [active] 395495009990 Presynaptic Site I dimer interface [polypeptide binding]; other site 395495009991 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 395495009992 Synaptic Flat tetramer interface [polypeptide binding]; other site 395495009993 Synaptic Site I dimer interface [polypeptide binding]; other site 395495009994 DNA binding site [nucleotide binding] 395495009995 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 395495009996 DNA-binding interface [nucleotide binding]; DNA binding site 395495009997 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 395495009998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395495009999 salt bridge; other site 395495010000 non-specific DNA binding site [nucleotide binding]; other site 395495010001 sequence-specific DNA binding site [nucleotide binding]; other site 395495010002 Cache domain; Region: Cache_1; pfam02743 395495010003 HAMP domain; Region: HAMP; pfam00672 395495010004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495010005 PAS domain; Region: PAS_9; pfam13426 395495010006 putative active site [active] 395495010007 heme pocket [chemical binding]; other site 395495010008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495010009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495010010 metal binding site [ion binding]; metal-binding site 395495010011 active site 395495010012 I-site; other site 395495010013 HAMP domain; Region: HAMP; pfam00672 395495010014 dimerization interface [polypeptide binding]; other site 395495010015 GAF domain; Region: GAF_2; pfam13185 395495010016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495010017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495010018 dimer interface [polypeptide binding]; other site 395495010019 phosphorylation site [posttranslational modification] 395495010020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495010021 ATP binding site [chemical binding]; other site 395495010022 G-X-G motif; other site 395495010023 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495010024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495010025 active site 395495010026 phosphorylation site [posttranslational modification] 395495010027 intermolecular recognition site; other site 395495010028 dimerization interface [polypeptide binding]; other site 395495010029 Response regulator receiver domain; Region: Response_reg; pfam00072 395495010030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495010031 active site 395495010032 phosphorylation site [posttranslational modification] 395495010033 intermolecular recognition site; other site 395495010034 dimerization interface [polypeptide binding]; other site 395495010035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495010036 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 395495010037 putative effector binding pocket; other site 395495010038 putative dimerization interface [polypeptide binding]; other site 395495010039 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 395495010040 tartrate dehydrogenase; Region: TTC; TIGR02089 395495010041 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 395495010042 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 395495010043 MOFRL family; Region: MOFRL; pfam05161 395495010044 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495010045 chaperone protein DnaJ; Provisional; Region: PRK14287 395495010046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395495010047 HSP70 interaction site [polypeptide binding]; other site 395495010048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 395495010049 Zn binding sites [ion binding]; other site 395495010050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395495010051 dimer interface [polypeptide binding]; other site 395495010052 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 395495010053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495010054 dimerization interface [polypeptide binding]; other site 395495010055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495010056 dimer interface [polypeptide binding]; other site 395495010057 putative CheW interface [polypeptide binding]; other site 395495010058 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 395495010059 classical (c) SDRs; Region: SDR_c; cd05233 395495010060 NAD(P) binding site [chemical binding]; other site 395495010061 active site 395495010062 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 395495010063 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 395495010064 Caspase domain; Region: Peptidase_C14; pfam00656 395495010065 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 395495010066 TIR domain; Region: TIR_2; pfam13676 395495010067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495010068 TPR motif; other site 395495010069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495010070 binding surface 395495010071 TPR motif; other site 395495010072 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 395495010073 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 395495010074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 395495010075 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 395495010076 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 395495010077 CHAT domain; Region: CHAT; cl17868 395495010078 short chain dehydrogenase; Provisional; Region: PRK06123 395495010079 classical (c) SDRs; Region: SDR_c; cd05233 395495010080 NAD(P) binding site [chemical binding]; other site 395495010081 active site 395495010082 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 395495010083 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495010084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495010085 metal binding site [ion binding]; metal-binding site 395495010086 active site 395495010087 I-site; other site 395495010088 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495010089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 395495010090 phosphate binding site [ion binding]; other site 395495010091 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 395495010092 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 395495010093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495010094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495010095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495010096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495010097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495010098 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495010099 TM-ABC transporter signature motif; other site 395495010100 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 395495010101 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495010102 Walker A/P-loop; other site 395495010103 ATP binding site [chemical binding]; other site 395495010104 Q-loop/lid; other site 395495010105 ABC transporter signature motif; other site 395495010106 Walker B; other site 395495010107 D-loop; other site 395495010108 H-loop/switch region; other site 395495010109 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495010110 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 395495010111 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 395495010112 putative ligand binding site [chemical binding]; other site 395495010113 ribulokinase; Provisional; Region: PRK04123 395495010114 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 395495010115 N- and C-terminal domain interface [polypeptide binding]; other site 395495010116 active site 395495010117 MgATP binding site [chemical binding]; other site 395495010118 catalytic site [active] 395495010119 metal binding site [ion binding]; metal-binding site 395495010120 carbohydrate binding site [chemical binding]; other site 395495010121 homodimer interface [polypeptide binding]; other site 395495010122 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 395495010123 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 395495010124 intersubunit interface [polypeptide binding]; other site 395495010125 active site 395495010126 Zn2+ binding site [ion binding]; other site 395495010127 L-arabinose isomerase; Provisional; Region: PRK02929 395495010128 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 395495010129 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 395495010130 trimer interface [polypeptide binding]; other site 395495010131 putative substrate binding site [chemical binding]; other site 395495010132 putative metal binding site [ion binding]; other site 395495010133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 395495010134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495010135 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 395495010136 conserved cys residue [active] 395495010137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495010138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495010139 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495010140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495010141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 395495010142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395495010143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 395495010144 Walker A/P-loop; other site 395495010145 ATP binding site [chemical binding]; other site 395495010146 Q-loop/lid; other site 395495010147 ABC transporter signature motif; other site 395495010148 Walker B; other site 395495010149 D-loop; other site 395495010150 H-loop/switch region; other site 395495010151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 395495010152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010153 dimer interface [polypeptide binding]; other site 395495010154 conserved gate region; other site 395495010155 putative PBP binding loops; other site 395495010156 ABC-ATPase subunit interface; other site 395495010157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010158 dimer interface [polypeptide binding]; other site 395495010159 conserved gate region; other site 395495010160 ABC-ATPase subunit interface; other site 395495010161 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395495010162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495010163 substrate binding pocket [chemical binding]; other site 395495010164 membrane-bound complex binding site; other site 395495010165 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 395495010166 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 395495010167 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 395495010168 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 395495010169 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 395495010170 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 395495010171 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 395495010172 putative active site [active] 395495010173 putative metal binding site [ion binding]; other site 395495010174 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 395495010175 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 395495010176 Tar ligand binding domain homologue; Region: TarH; pfam02203 395495010177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495010178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495010179 dimer interface [polypeptide binding]; other site 395495010180 putative CheW interface [polypeptide binding]; other site 395495010181 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 395495010182 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 395495010183 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 395495010184 putative active site [active] 395495010185 putative catalytic site [active] 395495010186 DctM-like transporters; Region: DctM; pfam06808 395495010187 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495010188 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 395495010189 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495010190 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495010191 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 395495010192 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 395495010193 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 395495010194 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 395495010195 glycerol kinase; Provisional; Region: glpK; PRK00047 395495010196 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 395495010197 N- and C-terminal domain interface [polypeptide binding]; other site 395495010198 active site 395495010199 MgATP binding site [chemical binding]; other site 395495010200 catalytic site [active] 395495010201 metal binding site [ion binding]; metal-binding site 395495010202 glycerol binding site [chemical binding]; other site 395495010203 homotetramer interface [polypeptide binding]; other site 395495010204 homodimer interface [polypeptide binding]; other site 395495010205 FBP binding site [chemical binding]; other site 395495010206 protein IIAGlc interface [polypeptide binding]; other site 395495010207 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 395495010208 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 395495010209 Peptidase C26; Region: Peptidase_C26; pfam07722 395495010210 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 395495010211 catalytic triad [active] 395495010212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495010213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010214 DNA binding site [nucleotide binding] 395495010215 domain linker motif; other site 395495010216 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 395495010217 ligand binding site [chemical binding]; other site 395495010218 dimerization interface [polypeptide binding]; other site 395495010219 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 395495010220 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 395495010221 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 395495010222 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 395495010223 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 395495010224 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 395495010225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 395495010226 TPR motif; other site 395495010227 binding surface 395495010228 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495010229 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495010230 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 395495010231 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 395495010232 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 395495010233 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 395495010234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495010235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010236 DNA binding site [nucleotide binding] 395495010237 domain linker motif; other site 395495010238 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 395495010239 putative dimerization interface [polypeptide binding]; other site 395495010240 putative ligand binding site [chemical binding]; other site 395495010241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495010242 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 395495010243 dimerization interface [polypeptide binding]; other site 395495010244 ligand binding site [chemical binding]; other site 395495010245 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 395495010246 alpha-galactosidase; Provisional; Region: PRK15076 395495010247 NAD binding site [chemical binding]; other site 395495010248 sugar binding site [chemical binding]; other site 395495010249 divalent metal binding site [ion binding]; other site 395495010250 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 395495010251 dimer interface [polypeptide binding]; other site 395495010252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395495010253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495010254 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495010255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010256 dimer interface [polypeptide binding]; other site 395495010257 conserved gate region; other site 395495010258 putative PBP binding loops; other site 395495010259 ABC-ATPase subunit interface; other site 395495010260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010261 dimer interface [polypeptide binding]; other site 395495010262 conserved gate region; other site 395495010263 putative PBP binding loops; other site 395495010264 ABC-ATPase subunit interface; other site 395495010265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495010266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010267 DNA binding site [nucleotide binding] 395495010268 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 395495010269 putative dimerization interface [polypeptide binding]; other site 395495010270 putative ligand binding site [chemical binding]; other site 395495010271 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 395495010272 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495010273 Walker A/P-loop; other site 395495010274 ATP binding site [chemical binding]; other site 395495010275 Q-loop/lid; other site 395495010276 ABC transporter signature motif; other site 395495010277 Walker B; other site 395495010278 D-loop; other site 395495010279 H-loop/switch region; other site 395495010280 TOBE domain; Region: TOBE_2; pfam08402 395495010281 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 395495010282 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 395495010283 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 395495010284 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 395495010285 Melibiase; Region: Melibiase; pfam02065 395495010286 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 395495010287 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 395495010288 NAD binding site [chemical binding]; other site 395495010289 homodimer interface [polypeptide binding]; other site 395495010290 active site 395495010291 substrate binding site [chemical binding]; other site 395495010292 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 395495010293 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 395495010294 dimer interface [polypeptide binding]; other site 395495010295 active site 395495010296 galactokinase; Provisional; Region: PRK05101 395495010297 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 395495010298 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395495010299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495010300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495010301 active site 395495010302 catalytic tetrad [active] 395495010303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395495010304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495010305 Walker A/P-loop; other site 395495010306 ATP binding site [chemical binding]; other site 395495010307 Q-loop/lid; other site 395495010308 ABC transporter signature motif; other site 395495010309 Walker B; other site 395495010310 D-loop; other site 395495010311 H-loop/switch region; other site 395495010312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395495010313 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395495010314 FtsX-like permease family; Region: FtsX; pfam02687 395495010315 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495010316 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495010317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495010318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495010319 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 395495010320 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 395495010321 substrate binding site [chemical binding]; other site 395495010322 catalytic Zn binding site [ion binding]; other site 395495010323 NAD binding site [chemical binding]; other site 395495010324 structural Zn binding site [ion binding]; other site 395495010325 dimer interface [polypeptide binding]; other site 395495010326 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 395495010327 S-formylglutathione hydrolase; Region: PLN02442 395495010328 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 395495010329 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 395495010330 putative ion selectivity filter; other site 395495010331 putative pore gating glutamate residue; other site 395495010332 putative H+/Cl- coupling transport residue; other site 395495010333 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 395495010334 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495010335 Cysteine-rich domain; Region: CCG; pfam02754 395495010336 Cysteine-rich domain; Region: CCG; pfam02754 395495010337 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 395495010338 FAD binding domain; Region: FAD_binding_4; pfam01565 395495010339 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 395495010340 FAD binding domain; Region: FAD_binding_4; pfam01565 395495010341 FIST N domain; Region: FIST; pfam08495 395495010342 FIST C domain; Region: FIST_C; pfam10442 395495010343 TraB family; Region: TraB; pfam01963 395495010344 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395495010345 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495010346 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 395495010347 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 395495010348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495010349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495010350 Walker A motif; other site 395495010351 ATP binding site [chemical binding]; other site 395495010352 Walker B motif; other site 395495010353 arginine finger; other site 395495010354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495010355 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495010356 Walker A motif; other site 395495010357 ATP binding site [chemical binding]; other site 395495010358 Walker B motif; other site 395495010359 arginine finger; other site 395495010360 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 395495010361 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 395495010362 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 395495010363 ligand binding site [chemical binding]; other site 395495010364 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 395495010365 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 395495010366 substrate binding pocket [chemical binding]; other site 395495010367 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 395495010368 B12 binding site [chemical binding]; other site 395495010369 cobalt ligand [ion binding]; other site 395495010370 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 395495010371 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 395495010372 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 395495010373 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 395495010374 gamma-glutamyl kinase; Provisional; Region: PRK05429 395495010375 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 395495010376 nucleotide binding site [chemical binding]; other site 395495010377 homotetrameric interface [polypeptide binding]; other site 395495010378 putative phosphate binding site [ion binding]; other site 395495010379 putative allosteric binding site; other site 395495010380 PUA domain; Region: PUA; pfam01472 395495010381 GTPase CgtA; Reviewed; Region: obgE; PRK12299 395495010382 GTP1/OBG; Region: GTP1_OBG; pfam01018 395495010383 Obg GTPase; Region: Obg; cd01898 395495010384 G1 box; other site 395495010385 GTP/Mg2+ binding site [chemical binding]; other site 395495010386 Switch I region; other site 395495010387 G2 box; other site 395495010388 G3 box; other site 395495010389 Switch II region; other site 395495010390 G4 box; other site 395495010391 G5 box; other site 395495010392 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 395495010393 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 395495010394 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 395495010395 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395495010396 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395495010397 substrate binding pocket [chemical binding]; other site 395495010398 chain length determination region; other site 395495010399 substrate-Mg2+ binding site; other site 395495010400 catalytic residues [active] 395495010401 aspartate-rich region 1; other site 395495010402 active site lid residues [active] 395495010403 aspartate-rich region 2; other site 395495010404 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 395495010405 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495010406 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 395495010407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495010408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495010409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495010410 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495010411 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495010412 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495010413 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 395495010414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010415 DNA binding site [nucleotide binding] 395495010416 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 395495010417 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495010418 putative ligand binding site [chemical binding]; other site 395495010419 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 395495010420 NACHT domain; Region: NACHT; pfam05729 395495010421 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 395495010422 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 395495010423 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 395495010424 putative active site [active] 395495010425 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 395495010426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 395495010427 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 395495010428 oligomerization interface [polypeptide binding]; other site 395495010429 active site 395495010430 metal binding site [ion binding]; metal-binding site 395495010431 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 395495010432 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 395495010433 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 395495010434 putative active site [active] 395495010435 putative substrate binding site [chemical binding]; other site 395495010436 putative cosubstrate binding site; other site 395495010437 catalytic site [active] 395495010438 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 395495010439 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 395495010440 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 395495010441 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 395495010442 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 395495010443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495010444 motif II; other site 395495010445 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 395495010446 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 395495010447 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495010448 putative ligand binding site [chemical binding]; other site 395495010449 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495010450 dimerization interface [polypeptide binding]; other site 395495010451 PAS domain; Region: PAS_9; pfam13426 395495010452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495010453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495010454 metal binding site [ion binding]; metal-binding site 395495010455 active site 395495010456 I-site; other site 395495010457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495010458 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395495010459 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 395495010460 active site 395495010461 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 395495010462 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 395495010463 substrate binding [chemical binding]; other site 395495010464 active site 395495010465 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 395495010466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495010467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010468 DNA binding site [nucleotide binding] 395495010469 domain linker motif; other site 395495010470 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495010471 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495010472 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395495010473 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 395495010474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010475 dimer interface [polypeptide binding]; other site 395495010476 conserved gate region; other site 395495010477 putative PBP binding loops; other site 395495010478 ABC-ATPase subunit interface; other site 395495010479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495010480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010481 dimer interface [polypeptide binding]; other site 395495010482 conserved gate region; other site 395495010483 putative PBP binding loops; other site 395495010484 ABC-ATPase subunit interface; other site 395495010485 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395495010486 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495010487 Walker A/P-loop; other site 395495010488 ATP binding site [chemical binding]; other site 395495010489 Q-loop/lid; other site 395495010490 ABC transporter signature motif; other site 395495010491 Walker B; other site 395495010492 D-loop; other site 395495010493 H-loop/switch region; other site 395495010494 TOBE domain; Region: TOBE_2; pfam08402 395495010495 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 395495010496 [2Fe-2S] cluster binding site [ion binding]; other site 395495010497 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 395495010498 Fatty acid desaturase; Region: FA_desaturase; pfam00487 395495010499 putative di-iron ligands [ion binding]; other site 395495010500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495010501 DNA binding site [nucleotide binding] 395495010502 domain linker motif; other site 395495010503 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 395495010504 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495010505 putative ligand binding site [chemical binding]; other site 395495010506 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 395495010507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495010508 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 395495010509 dimerization interface [polypeptide binding]; other site 395495010510 substrate binding pocket [chemical binding]; other site 395495010511 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 395495010512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495010513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495010514 metal binding site [ion binding]; metal-binding site 395495010515 active site 395495010516 I-site; other site 395495010517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495010518 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 395495010519 TM-ABC transporter signature motif; other site 395495010520 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 395495010521 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495010522 Walker A/P-loop; other site 395495010523 ATP binding site [chemical binding]; other site 395495010524 Q-loop/lid; other site 395495010525 ABC transporter signature motif; other site 395495010526 Walker B; other site 395495010527 D-loop; other site 395495010528 H-loop/switch region; other site 395495010529 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495010530 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 395495010531 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 395495010532 putative ligand binding site [chemical binding]; other site 395495010533 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 395495010534 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 395495010535 substrate binding site [chemical binding]; other site 395495010536 ATP binding site [chemical binding]; other site 395495010537 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 395495010538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 395495010539 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 395495010540 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 395495010541 PYR/PP interface [polypeptide binding]; other site 395495010542 dimer interface [polypeptide binding]; other site 395495010543 TPP binding site [chemical binding]; other site 395495010544 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 395495010545 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 395495010546 TPP-binding site; other site 395495010547 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395495010548 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 395495010549 putative oxidoreductase; Provisional; Region: PRK11579 395495010550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495010551 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495010552 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 395495010553 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 395495010554 glycogen branching enzyme; Provisional; Region: PRK05402 395495010555 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 395495010556 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 395495010557 active site 395495010558 catalytic site [active] 395495010559 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 395495010560 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 395495010561 trehalose synthase; Region: treS_nterm; TIGR02456 395495010562 active site 395495010563 catalytic site [active] 395495010564 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 395495010565 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 395495010566 Ca binding site [ion binding]; other site 395495010567 active site 395495010568 catalytic site [active] 395495010569 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 395495010570 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495010571 Walker A/P-loop; other site 395495010572 ATP binding site [chemical binding]; other site 395495010573 Q-loop/lid; other site 395495010574 ABC transporter signature motif; other site 395495010575 Walker B; other site 395495010576 D-loop; other site 395495010577 H-loop/switch region; other site 395495010578 TOBE domain; Region: TOBE; pfam03459 395495010579 TOBE domain; Region: TOBE_2; pfam08402 395495010580 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 395495010581 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 395495010582 active site 395495010583 catalytic site [active] 395495010584 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 395495010585 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 395495010586 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 395495010587 active site 395495010588 catalytic site [active] 395495010589 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 395495010590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495010591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010592 dimer interface [polypeptide binding]; other site 395495010593 conserved gate region; other site 395495010594 ABC-ATPase subunit interface; other site 395495010595 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 395495010596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495010597 dimer interface [polypeptide binding]; other site 395495010598 conserved gate region; other site 395495010599 putative PBP binding loops; other site 395495010600 ABC-ATPase subunit interface; other site 395495010601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395495010602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495010603 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 395495010604 Glucokinase; Region: Glucokinase; cl17310 395495010605 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 395495010606 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 395495010607 putative active site [active] 395495010608 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 395495010609 active site 395495010610 catalytic residues [active] 395495010611 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 395495010612 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 395495010613 tetrameric interface [polypeptide binding]; other site 395495010614 NAD binding site [chemical binding]; other site 395495010615 catalytic residues [active] 395495010616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495010617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495010618 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495010619 putative effector binding pocket; other site 395495010620 dimerization interface [polypeptide binding]; other site 395495010621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495010622 short chain dehydrogenase; Provisional; Region: PRK06924 395495010623 NAD(P) binding site [chemical binding]; other site 395495010624 active site 395495010625 Peptidase family M48; Region: Peptidase_M48; cl12018 395495010626 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 395495010627 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495010628 Ligand Binding Site [chemical binding]; other site 395495010629 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 395495010630 active site 1 [active] 395495010631 dimer interface [polypeptide binding]; other site 395495010632 hexamer interface [polypeptide binding]; other site 395495010633 active site 2 [active] 395495010634 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 395495010635 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 395495010636 active site 395495010637 catalytic residues [active] 395495010638 metal binding site [ion binding]; metal-binding site 395495010639 DmpG-like communication domain; Region: DmpG_comm; pfam07836 395495010640 acetaldehyde dehydrogenase; Validated; Region: PRK08300 395495010641 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 395495010642 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 395495010643 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 395495010644 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 395495010645 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 395495010646 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 395495010647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495010648 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 395495010649 dimerization interface [polypeptide binding]; other site 395495010650 putative substrate binding pocket [chemical binding]; other site 395495010651 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 395495010652 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 395495010653 dimerization interface [polypeptide binding]; other site 395495010654 ligand binding site [chemical binding]; other site 395495010655 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 395495010656 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 395495010657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495010658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495010659 dimerization interface [polypeptide binding]; other site 395495010660 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 395495010661 transmembrane helices; other site 395495010662 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395495010663 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 395495010664 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 395495010665 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 395495010666 active site 395495010667 NTP binding site [chemical binding]; other site 395495010668 metal binding triad [ion binding]; metal-binding site 395495010669 antibiotic binding site [chemical binding]; other site 395495010670 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 395495010671 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 395495010672 NAD binding site [chemical binding]; other site 395495010673 catalytic residues [active] 395495010674 Domain of unknown function (DUF336); Region: DUF336; pfam03928 395495010675 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 395495010676 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 395495010677 tetramer interface [polypeptide binding]; other site 395495010678 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 395495010679 tetramer interface [polypeptide binding]; other site 395495010680 active site 395495010681 Fe binding site [ion binding]; other site 395495010682 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 395495010683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495010684 catalytic loop [active] 395495010685 iron binding site [ion binding]; other site 395495010686 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 395495010687 FAD binding pocket [chemical binding]; other site 395495010688 FAD binding motif [chemical binding]; other site 395495010689 phosphate binding motif [ion binding]; other site 395495010690 beta-alpha-beta structure motif; other site 395495010691 NAD binding pocket [chemical binding]; other site 395495010692 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 395495010693 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 395495010694 dimerization interface [polypeptide binding]; other site 395495010695 putative path to active site cavity [active] 395495010696 diiron center [ion binding]; other site 395495010697 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 395495010698 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 395495010699 dimerization interface [polypeptide binding]; other site 395495010700 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 395495010701 Activator of aromatic catabolism; Region: XylR_N; pfam06505 395495010702 V4R domain; Region: V4R; pfam02830 395495010703 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 395495010704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495010705 Walker A motif; other site 395495010706 ATP binding site [chemical binding]; other site 395495010707 Walker B motif; other site 395495010708 arginine finger; other site 395495010709 Transcriptional regulators [Transcription]; Region: FadR; COG2186 395495010710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495010711 DNA-binding site [nucleotide binding]; DNA binding site 395495010712 FCD domain; Region: FCD; pfam07729 395495010713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495010714 putative active site [active] 395495010715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495010716 heme pocket [chemical binding]; other site 395495010717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495010718 dimer interface [polypeptide binding]; other site 395495010719 phosphorylation site [posttranslational modification] 395495010720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495010721 ATP binding site [chemical binding]; other site 395495010722 Mg2+ binding site [ion binding]; other site 395495010723 G-X-G motif; other site 395495010724 Response regulator receiver domain; Region: Response_reg; pfam00072 395495010725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495010726 active site 395495010727 phosphorylation site [posttranslational modification] 395495010728 intermolecular recognition site; other site 395495010729 dimerization interface [polypeptide binding]; other site 395495010730 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 395495010731 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 395495010732 active site residue [active] 395495010733 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 395495010734 active site residue [active] 395495010735 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495010736 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 395495010737 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 395495010738 putative active site [active] 395495010739 catalytic site [active] 395495010740 putative metal binding site [ion binding]; other site 395495010741 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 395495010742 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 395495010743 [2Fe-2S] cluster binding site [ion binding]; other site 395495010744 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 395495010745 alpha subunit interface [polypeptide binding]; other site 395495010746 active site 395495010747 substrate binding site [chemical binding]; other site 395495010748 Fe binding site [ion binding]; other site 395495010749 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 395495010750 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 395495010751 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 395495010752 substrate binding pocket [chemical binding]; other site 395495010753 chain length determination region; other site 395495010754 substrate-Mg2+ binding site; other site 395495010755 catalytic residues [active] 395495010756 aspartate-rich region 1; other site 395495010757 active site lid residues [active] 395495010758 aspartate-rich region 2; other site 395495010759 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 395495010760 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 395495010761 TPP-binding site; other site 395495010762 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395495010763 PYR/PP interface [polypeptide binding]; other site 395495010764 dimer interface [polypeptide binding]; other site 395495010765 TPP binding site [chemical binding]; other site 395495010766 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395495010767 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 395495010768 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 395495010769 HSP70 interaction site [polypeptide binding]; other site 395495010770 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 395495010771 substrate binding site [polypeptide binding]; other site 395495010772 dimer interface [polypeptide binding]; other site 395495010773 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 395495010774 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 395495010775 putative dimer interface [polypeptide binding]; other site 395495010776 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 395495010777 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 395495010778 putative dimer interface [polypeptide binding]; other site 395495010779 Cytochrome c553 [Energy production and conversion]; Region: COG2863 395495010780 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 395495010781 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 395495010782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495010783 Walker A motif; other site 395495010784 ATP binding site [chemical binding]; other site 395495010785 Walker B motif; other site 395495010786 arginine finger; other site 395495010787 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 395495010788 DNA-binding interface [nucleotide binding]; DNA binding site 395495010789 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 395495010790 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 395495010791 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 395495010792 putative [4Fe-4S] binding site [ion binding]; other site 395495010793 putative molybdopterin cofactor binding site [chemical binding]; other site 395495010794 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 395495010795 putative molybdopterin cofactor binding site; other site 395495010796 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 395495010797 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 395495010798 metal binding site [ion binding]; metal-binding site 395495010799 putative dimer interface [polypeptide binding]; other site 395495010800 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 395495010801 conserved cys residue [active] 395495010802 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 395495010803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495010804 motif II; other site 395495010805 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 395495010806 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 395495010807 active site 395495010808 dimer interface [polypeptide binding]; other site 395495010809 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 395495010810 dimer interface [polypeptide binding]; other site 395495010811 active site 395495010812 transaldolase-like protein; Provisional; Region: PTZ00411 395495010813 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 395495010814 active site 395495010815 dimer interface [polypeptide binding]; other site 395495010816 catalytic residue [active] 395495010817 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 395495010818 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 395495010819 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 395495010820 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 395495010821 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 395495010822 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 395495010823 putative active site [active] 395495010824 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395495010825 anti sigma factor interaction site; other site 395495010826 regulatory phosphorylation site [posttranslational modification]; other site 395495010827 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 395495010828 VacJ like lipoprotein; Region: VacJ; cl01073 395495010829 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 395495010830 mce related protein; Region: MCE; pfam02470 395495010831 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 395495010832 Permease; Region: Permease; pfam02405 395495010833 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 395495010834 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 395495010835 Walker A/P-loop; other site 395495010836 ATP binding site [chemical binding]; other site 395495010837 Q-loop/lid; other site 395495010838 ABC transporter signature motif; other site 395495010839 Walker B; other site 395495010840 D-loop; other site 395495010841 H-loop/switch region; other site 395495010842 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 395495010843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495010844 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 395495010845 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 395495010846 active site 395495010847 dimer interface [polypeptide binding]; other site 395495010848 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 395495010849 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 395495010850 active site 395495010851 FMN binding site [chemical binding]; other site 395495010852 substrate binding site [chemical binding]; other site 395495010853 3Fe-4S cluster binding site [ion binding]; other site 395495010854 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 395495010855 domain interface; other site 395495010856 Transposase IS200 like; Region: Y1_Tnp; cl00848 395495010857 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 395495010858 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 395495010859 dimer interface [polypeptide binding]; other site 395495010860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495010861 catalytic residue [active] 395495010862 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 395495010863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495010864 Zn2+ binding site [ion binding]; other site 395495010865 Mg2+ binding site [ion binding]; other site 395495010866 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 395495010867 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 395495010868 active site 395495010869 dimer interface [polypeptide binding]; other site 395495010870 metal binding site [ion binding]; metal-binding site 395495010871 shikimate kinase; Reviewed; Region: aroK; PRK00131 395495010872 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 395495010873 ADP binding site [chemical binding]; other site 395495010874 magnesium binding site [ion binding]; other site 395495010875 putative shikimate binding site; other site 395495010876 AMIN domain; Region: AMIN; pfam11741 395495010877 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 395495010878 Secretin and TonB N terminus short domain; Region: STN; pfam07660 395495010879 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495010880 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495010881 Pilus assembly protein, PilP; Region: PilP; pfam04351 395495010882 Pilus assembly protein, PilO; Region: PilO; pfam04350 395495010883 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 395495010884 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 395495010885 Competence protein A; Region: Competence_A; pfam11104 395495010886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 395495010887 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 395495010888 Transglycosylase; Region: Transgly; pfam00912 395495010889 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 395495010890 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 395495010891 putative iron binding site [ion binding]; other site 395495010892 diaminopimelate decarboxylase; Region: lysA; TIGR01048 395495010893 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 395495010894 active site 395495010895 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 395495010896 substrate binding site [chemical binding]; other site 395495010897 catalytic residues [active] 395495010898 dimer interface [polypeptide binding]; other site 395495010899 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 395495010900 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495010901 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495010902 trimer interface [polypeptide binding]; other site 395495010903 eyelet of channel; other site 395495010904 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495010905 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495010906 trimer interface [polypeptide binding]; other site 395495010907 eyelet of channel; other site 395495010908 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 395495010909 diiron binding motif [ion binding]; other site 395495010910 OsmC-like protein; Region: OsmC; cl00767 395495010911 threonine dehydratase; Reviewed; Region: PRK09224 395495010912 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 395495010913 tetramer interface [polypeptide binding]; other site 395495010914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495010915 catalytic residue [active] 395495010916 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 395495010917 putative Ile/Val binding site [chemical binding]; other site 395495010918 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 395495010919 putative Ile/Val binding site [chemical binding]; other site 395495010920 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 395495010921 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 395495010922 putative dimer interface [polypeptide binding]; other site 395495010923 active site pocket [active] 395495010924 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 395495010925 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 395495010926 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 395495010927 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495010928 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 395495010929 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 395495010930 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 395495010931 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 395495010932 GspL periplasmic domain; Region: GspL_C; cl14909 395495010933 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 395495010934 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495010935 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495010936 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495010937 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 395495010938 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495010939 type II secretion system protein E; Region: type_II_gspE; TIGR02533 395495010940 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395495010941 Walker A motif; other site 395495010942 ATP binding site [chemical binding]; other site 395495010943 Walker B motif; other site 395495010944 type II secretion system protein F; Region: GspF; TIGR02120 395495010945 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495010946 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495010947 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 395495010948 haemagglutination activity domain; Region: Haemagg_act; smart00912 395495010949 flagellin; Validated; Region: PRK08026 395495010950 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495010951 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 395495010952 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 395495010953 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 395495010954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495010955 Walker A motif; other site 395495010956 ATP binding site [chemical binding]; other site 395495010957 Walker B motif; other site 395495010958 arginine finger; other site 395495010959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495010960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495010961 ligand binding site [chemical binding]; other site 395495010962 flexible hinge region; other site 395495010963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495010964 non-specific DNA interactions [nucleotide binding]; other site 395495010965 DNA binding site [nucleotide binding] 395495010966 sequence specific DNA binding site [nucleotide binding]; other site 395495010967 putative cAMP binding site [chemical binding]; other site 395495010968 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495010969 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 395495010970 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 395495010971 acyl-activating enzyme (AAE) consensus motif; other site 395495010972 acyl-activating enzyme (AAE) consensus motif; other site 395495010973 putative AMP binding site [chemical binding]; other site 395495010974 putative active site [active] 395495010975 putative CoA binding site [chemical binding]; other site 395495010976 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495010977 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495010978 Walker A/P-loop; other site 395495010979 ATP binding site [chemical binding]; other site 395495010980 Q-loop/lid; other site 395495010981 ABC transporter signature motif; other site 395495010982 Walker B; other site 395495010983 D-loop; other site 395495010984 H-loop/switch region; other site 395495010985 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495010986 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495010987 TM-ABC transporter signature motif; other site 395495010988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495010989 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495010990 TM-ABC transporter signature motif; other site 395495010991 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 395495010992 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495010993 putative ligand binding site [chemical binding]; other site 395495010994 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495010995 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495010996 Walker A/P-loop; other site 395495010997 ATP binding site [chemical binding]; other site 395495010998 Q-loop/lid; other site 395495010999 ABC transporter signature motif; other site 395495011000 Walker B; other site 395495011001 D-loop; other site 395495011002 H-loop/switch region; other site 395495011003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495011004 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 395495011005 acyl-activating enzyme (AAE) consensus motif; other site 395495011006 active site 395495011007 AMP binding site [chemical binding]; other site 395495011008 CoA binding site [chemical binding]; other site 395495011009 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495011010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495011011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011012 active site 395495011013 phosphorylation site [posttranslational modification] 395495011014 intermolecular recognition site; other site 395495011015 dimerization interface [polypeptide binding]; other site 395495011016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495011017 DNA binding site [nucleotide binding] 395495011018 sensor protein QseC; Provisional; Region: PRK10337 395495011019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011020 dimer interface [polypeptide binding]; other site 395495011021 phosphorylation site [posttranslational modification] 395495011022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011023 ATP binding site [chemical binding]; other site 395495011024 Mg2+ binding site [ion binding]; other site 395495011025 G-X-G motif; other site 395495011026 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 395495011027 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 395495011028 active site 395495011029 HIGH motif; other site 395495011030 dimer interface [polypeptide binding]; other site 395495011031 KMSKS motif; other site 395495011032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495011033 RNA binding surface [nucleotide binding]; other site 395495011034 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 395495011035 Peptidase family M23; Region: Peptidase_M23; pfam01551 395495011036 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 395495011037 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 395495011038 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 395495011039 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 395495011040 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 395495011041 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 395495011042 23S rRNA interface [nucleotide binding]; other site 395495011043 L3 interface [polypeptide binding]; other site 395495011044 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 395495011045 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 395495011046 putative ligand binding site [chemical binding]; other site 395495011047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495011048 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495011049 TM-ABC transporter signature motif; other site 395495011050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495011051 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495011052 TM-ABC transporter signature motif; other site 395495011053 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 395495011054 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495011055 Walker A/P-loop; other site 395495011056 ATP binding site [chemical binding]; other site 395495011057 Q-loop/lid; other site 395495011058 ABC transporter signature motif; other site 395495011059 Walker B; other site 395495011060 D-loop; other site 395495011061 H-loop/switch region; other site 395495011062 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495011063 guanine deaminase; Provisional; Region: PRK09228 395495011064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395495011065 active site 395495011066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495011067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495011068 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 395495011069 putative substrate binding pocket [chemical binding]; other site 395495011070 putative dimerization interface [polypeptide binding]; other site 395495011071 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 395495011072 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495011073 catalytic loop [active] 395495011074 iron binding site [ion binding]; other site 395495011075 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395495011076 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 395495011077 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 395495011078 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 395495011079 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495011080 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395495011081 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 395495011082 XdhC Rossmann domain; Region: XdhC_C; pfam13478 395495011083 MASE1; Region: MASE1; cl17823 395495011084 PAS domain S-box; Region: sensory_box; TIGR00229 395495011085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011086 putative active site [active] 395495011087 heme pocket [chemical binding]; other site 395495011088 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395495011089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011090 putative active site [active] 395495011091 heme pocket [chemical binding]; other site 395495011092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011093 dimer interface [polypeptide binding]; other site 395495011094 phosphorylation site [posttranslational modification] 395495011095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011096 ATP binding site [chemical binding]; other site 395495011097 Mg2+ binding site [ion binding]; other site 395495011098 G-X-G motif; other site 395495011099 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495011100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011101 active site 395495011102 phosphorylation site [posttranslational modification] 395495011103 intermolecular recognition site; other site 395495011104 dimerization interface [polypeptide binding]; other site 395495011105 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011107 active site 395495011108 phosphorylation site [posttranslational modification] 395495011109 intermolecular recognition site; other site 395495011110 dimerization interface [polypeptide binding]; other site 395495011111 Hpt domain; Region: Hpt; pfam01627 395495011112 putative binding surface; other site 395495011113 active site 395495011114 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011116 active site 395495011117 phosphorylation site [posttranslational modification] 395495011118 intermolecular recognition site; other site 395495011119 dimerization interface [polypeptide binding]; other site 395495011120 PAS fold; Region: PAS_3; pfam08447 395495011121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011122 heme pocket [chemical binding]; other site 395495011123 putative active site [active] 395495011124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011126 metal binding site [ion binding]; metal-binding site 395495011127 active site 395495011128 I-site; other site 395495011129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495011130 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 395495011131 Transglycosylase; Region: Transgly; cl17702 395495011132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 395495011133 PAS domain S-box; Region: sensory_box; TIGR00229 395495011134 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011135 putative active site [active] 395495011136 heme pocket [chemical binding]; other site 395495011137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011138 PAS domain; Region: PAS_9; pfam13426 395495011139 putative active site [active] 395495011140 heme pocket [chemical binding]; other site 395495011141 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011143 metal binding site [ion binding]; metal-binding site 395495011144 active site 395495011145 I-site; other site 395495011146 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495011147 integrase; Provisional; Region: PRK09692 395495011148 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 395495011149 active site 395495011150 Int/Topo IB signature motif; other site 395495011151 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 395495011152 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 395495011153 active site 395495011154 metal binding site [ion binding]; metal-binding site 395495011155 interdomain interaction site; other site 395495011156 Domain of unknown function (DUF927); Region: DUF927; pfam06048 395495011157 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 395495011158 eyelet of channel; other site 395495011159 trimer interface [polypeptide binding]; other site 395495011160 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 395495011161 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 395495011162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495011163 dimer interface [polypeptide binding]; other site 395495011164 putative CheW interface [polypeptide binding]; other site 395495011165 FOG: CBS domain [General function prediction only]; Region: COG0517 395495011166 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 395495011167 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 395495011168 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 395495011169 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 395495011170 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 395495011171 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 395495011172 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 395495011173 Walker A/P-loop; other site 395495011174 ATP binding site [chemical binding]; other site 395495011175 Q-loop/lid; other site 395495011176 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 395495011177 ABC transporter signature motif; other site 395495011178 Walker B; other site 395495011179 D-loop; other site 395495011180 H-loop/switch region; other site 395495011181 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 395495011182 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 395495011183 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 395495011184 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 395495011185 minor groove reading motif; other site 395495011186 helix-hairpin-helix signature motif; other site 395495011187 substrate binding pocket [chemical binding]; other site 395495011188 active site 395495011189 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 395495011190 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 395495011191 DNA binding and oxoG recognition site [nucleotide binding] 395495011192 Dynamin family; Region: Dynamin_N; pfam00350 395495011193 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 395495011194 G1 box; other site 395495011195 GTP/Mg2+ binding site [chemical binding]; other site 395495011196 G2 box; other site 395495011197 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 395495011198 G3 box; other site 395495011199 Switch II region; other site 395495011200 GTP/Mg2+ binding site [chemical binding]; other site 395495011201 G4 box; other site 395495011202 G5 box; other site 395495011203 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 395495011204 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 395495011205 DNA binding site [nucleotide binding] 395495011206 catalytic residue [active] 395495011207 H2TH interface [polypeptide binding]; other site 395495011208 putative catalytic residues [active] 395495011209 turnover-facilitating residue; other site 395495011210 intercalation triad [nucleotide binding]; other site 395495011211 8OG recognition residue [nucleotide binding]; other site 395495011212 putative reading head residues; other site 395495011213 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 395495011214 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 395495011215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495011216 binding surface 395495011217 TPR motif; other site 395495011218 TPR repeat; Region: TPR_11; pfam13414 395495011219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495011220 binding surface 395495011221 TPR motif; other site 395495011222 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 395495011223 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 395495011224 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 395495011225 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 395495011226 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 395495011227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495011228 active site 395495011229 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 395495011230 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 395495011231 5S rRNA interface [nucleotide binding]; other site 395495011232 CTC domain interface [polypeptide binding]; other site 395495011233 L16 interface [polypeptide binding]; other site 395495011234 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 395495011235 putative active site [active] 395495011236 catalytic residue [active] 395495011237 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 395495011238 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 395495011239 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 395495011240 active site 395495011241 (T/H)XGH motif; other site 395495011242 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 395495011243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495011244 S-adenosylmethionine binding site [chemical binding]; other site 395495011245 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 395495011246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 395495011247 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 395495011248 AAA ATPase domain; Region: AAA_16; pfam13191 395495011249 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 395495011250 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 395495011251 Chain length determinant protein; Region: Wzz; pfam02706 395495011252 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 395495011253 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 395495011254 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 395495011255 SLBB domain; Region: SLBB; pfam10531 395495011256 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 395495011257 Bacterial sugar transferase; Region: Bac_transf; pfam02397 395495011258 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 395495011259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495011260 S-adenosylmethionine binding site [chemical binding]; other site 395495011261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 395495011262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495011263 catalytic core [active] 395495011264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495011265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395495011266 active site residue [active] 395495011267 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 395495011268 GSH binding site [chemical binding]; other site 395495011269 catalytic residues [active] 395495011270 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 395495011271 potassium uptake protein; Region: kup; TIGR00794 395495011272 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 395495011273 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395495011274 metal binding triad; other site 395495011275 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 395495011276 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 395495011277 metal binding triad; other site 395495011278 TIGR02099 family protein; Region: TIGR02099 395495011279 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 395495011280 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 395495011281 putative active site [active] 395495011282 catalytic triad [active] 395495011283 dimer interface [polypeptide binding]; other site 395495011284 hypothetical protein; Provisional; Region: PRK06996 395495011285 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495011286 primosome assembly protein PriA; Validated; Region: PRK05580 395495011287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495011288 ATP binding site [chemical binding]; other site 395495011289 putative Mg++ binding site [ion binding]; other site 395495011290 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 395495011291 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 395495011292 substrate binding site [chemical binding]; other site 395495011293 active site 395495011294 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 395495011295 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 395495011296 gamma subunit interface [polypeptide binding]; other site 395495011297 LBP interface [polypeptide binding]; other site 395495011298 epsilon subunit interface [polypeptide binding]; other site 395495011299 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 395495011300 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 395495011301 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 395495011302 alpha subunit interaction interface [polypeptide binding]; other site 395495011303 Walker A motif; other site 395495011304 ATP binding site [chemical binding]; other site 395495011305 Walker B motif; other site 395495011306 inhibitor binding site; inhibition site 395495011307 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395495011308 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 395495011309 core domain interface [polypeptide binding]; other site 395495011310 delta subunit interface [polypeptide binding]; other site 395495011311 epsilon subunit interface [polypeptide binding]; other site 395495011312 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 395495011313 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 395495011314 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 395495011315 beta subunit interaction interface [polypeptide binding]; other site 395495011316 Walker A motif; other site 395495011317 ATP binding site [chemical binding]; other site 395495011318 Walker B motif; other site 395495011319 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 395495011320 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 395495011321 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 395495011322 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 395495011323 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 395495011324 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 395495011325 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 395495011326 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 395495011327 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 395495011328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395495011329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495011330 Coenzyme A binding pocket [chemical binding]; other site 395495011331 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 395495011332 Cytochrome C' Region: Cytochrom_C_2; pfam01322 395495011333 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 395495011334 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 395495011335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495011336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495011337 homodimer interface [polypeptide binding]; other site 395495011338 catalytic residue [active] 395495011339 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 395495011340 EamA-like transporter family; Region: EamA; pfam00892 395495011341 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 395495011342 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 395495011343 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 395495011344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495011345 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 395495011346 DNA binding residues [nucleotide binding] 395495011347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011348 PAS domain; Region: PAS_9; pfam13426 395495011349 putative active site [active] 395495011350 heme pocket [chemical binding]; other site 395495011351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011352 PAS fold; Region: PAS_3; pfam08447 395495011353 putative active site [active] 395495011354 heme pocket [chemical binding]; other site 395495011355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011356 putative active site [active] 395495011357 PAS fold; Region: PAS_3; pfam08447 395495011358 heme pocket [chemical binding]; other site 395495011359 PAS fold; Region: PAS_3; pfam08447 395495011360 PAS fold; Region: PAS_7; pfam12860 395495011361 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495011362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011363 dimer interface [polypeptide binding]; other site 395495011364 phosphorylation site [posttranslational modification] 395495011365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011366 ATP binding site [chemical binding]; other site 395495011367 Mg2+ binding site [ion binding]; other site 395495011368 G-X-G motif; other site 395495011369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011370 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011371 active site 395495011372 phosphorylation site [posttranslational modification] 395495011373 intermolecular recognition site; other site 395495011374 dimerization interface [polypeptide binding]; other site 395495011375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011376 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011377 active site 395495011378 phosphorylation site [posttranslational modification] 395495011379 intermolecular recognition site; other site 395495011380 dimerization interface [polypeptide binding]; other site 395495011381 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495011382 putative binding surface; other site 395495011383 active site 395495011384 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011386 active site 395495011387 phosphorylation site [posttranslational modification] 395495011388 intermolecular recognition site; other site 395495011389 dimerization interface [polypeptide binding]; other site 395495011390 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011391 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011392 metal binding site [ion binding]; metal-binding site 395495011393 active site 395495011394 I-site; other site 395495011395 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011397 metal binding site [ion binding]; metal-binding site 395495011398 active site 395495011399 I-site; other site 395495011400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495011401 PAS domain S-box; Region: sensory_box; TIGR00229 395495011402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011403 putative active site [active] 395495011404 heme pocket [chemical binding]; other site 395495011405 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011406 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011407 metal binding site [ion binding]; metal-binding site 395495011408 active site 395495011409 I-site; other site 395495011410 photoactive yellow protein; Region: photo_yellow; TIGR02373 395495011411 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 395495011412 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 395495011413 translation initiation factor Sui1; Validated; Region: PRK06824 395495011414 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 395495011415 putative rRNA binding site [nucleotide binding]; other site 395495011416 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395495011417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495011418 catalytic residues [active] 395495011419 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395495011420 active site residue [active] 395495011421 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 395495011422 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 395495011423 [2Fe-2S] cluster binding site [ion binding]; other site 395495011424 PAS domain; Region: PAS_9; pfam13426 395495011425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495011426 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 395495011427 Walker A motif; other site 395495011428 ATP binding site [chemical binding]; other site 395495011429 Walker B motif; other site 395495011430 arginine finger; other site 395495011431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495011432 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 395495011433 Water Stress and Hypersensitive response; Region: WHy; smart00769 395495011434 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 395495011435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395495011436 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395495011437 FtsX-like permease family; Region: FtsX; pfam02687 395495011438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495011439 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 395495011440 Walker A/P-loop; other site 395495011441 ATP binding site [chemical binding]; other site 395495011442 Q-loop/lid; other site 395495011443 ABC transporter signature motif; other site 395495011444 Walker B; other site 395495011445 D-loop; other site 395495011446 H-loop/switch region; other site 395495011447 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 395495011448 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 395495011449 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 395495011450 intersubunit interface [polypeptide binding]; other site 395495011451 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 395495011452 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 395495011453 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 395495011454 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 395495011455 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 395495011456 metal binding site 2 [ion binding]; metal-binding site 395495011457 putative DNA binding helix; other site 395495011458 metal binding site 1 [ion binding]; metal-binding site 395495011459 dimer interface [polypeptide binding]; other site 395495011460 structural Zn2+ binding site [ion binding]; other site 395495011461 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 395495011462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 395495011463 IHF dimer interface [polypeptide binding]; other site 395495011464 IHF - DNA interface [nucleotide binding]; other site 395495011465 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 395495011466 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 395495011467 substrate binding site [chemical binding]; other site 395495011468 dimer interface [polypeptide binding]; other site 395495011469 NADP binding site [chemical binding]; other site 395495011470 catalytic residues [active] 395495011471 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 395495011472 active site 2 [active] 395495011473 active site 1 [active] 395495011474 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 395495011475 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 395495011476 FAD binding pocket [chemical binding]; other site 395495011477 FAD binding motif [chemical binding]; other site 395495011478 phosphate binding motif [ion binding]; other site 395495011479 beta-alpha-beta structure motif; other site 395495011480 NAD(p) ribose binding residues [chemical binding]; other site 395495011481 NAD binding pocket [chemical binding]; other site 395495011482 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 395495011483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495011484 catalytic loop [active] 395495011485 iron binding site [ion binding]; other site 395495011486 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 395495011487 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 395495011488 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 395495011489 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 395495011490 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 395495011491 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 395495011492 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 395495011493 putative ligand binding site [chemical binding]; other site 395495011494 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 395495011495 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 395495011496 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 395495011497 Walker A/P-loop; other site 395495011498 ATP binding site [chemical binding]; other site 395495011499 Q-loop/lid; other site 395495011500 ABC transporter signature motif; other site 395495011501 Walker B; other site 395495011502 D-loop; other site 395495011503 H-loop/switch region; other site 395495011504 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 395495011505 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495011506 TM-ABC transporter signature motif; other site 395495011507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495011508 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 395495011509 TM-ABC transporter signature motif; other site 395495011510 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 395495011511 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 395495011512 putative MPT binding site; other site 395495011513 glutamine synthetase; Provisional; Region: glnA; PRK09469 395495011514 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 395495011515 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 395495011516 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395495011517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011518 putative active site [active] 395495011519 heme pocket [chemical binding]; other site 395495011520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011521 dimer interface [polypeptide binding]; other site 395495011522 phosphorylation site [posttranslational modification] 395495011523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011524 ATP binding site [chemical binding]; other site 395495011525 Mg2+ binding site [ion binding]; other site 395495011526 G-X-G motif; other site 395495011527 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 395495011528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011529 active site 395495011530 phosphorylation site [posttranslational modification] 395495011531 intermolecular recognition site; other site 395495011532 dimerization interface [polypeptide binding]; other site 395495011533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495011534 Walker A motif; other site 395495011535 ATP binding site [chemical binding]; other site 395495011536 Walker B motif; other site 395495011537 arginine finger; other site 395495011538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495011539 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495011540 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495011541 ligand binding site [chemical binding]; other site 395495011542 flexible hinge region; other site 395495011543 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495011544 non-specific DNA interactions [nucleotide binding]; other site 395495011545 DNA binding site [nucleotide binding] 395495011546 sequence specific DNA binding site [nucleotide binding]; other site 395495011547 putative cAMP binding site [chemical binding]; other site 395495011548 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395495011549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 395495011550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011551 active site 395495011552 phosphorylation site [posttranslational modification] 395495011553 intermolecular recognition site; other site 395495011554 dimerization interface [polypeptide binding]; other site 395495011555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495011556 DNA binding site [nucleotide binding] 395495011557 PAS fold; Region: PAS_7; pfam12860 395495011558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 395495011559 putative active site [active] 395495011560 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395495011561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011562 dimer interface [polypeptide binding]; other site 395495011563 phosphorylation site [posttranslational modification] 395495011564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011565 ATP binding site [chemical binding]; other site 395495011566 G-X-G motif; other site 395495011567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011568 active site 395495011569 phosphorylation site [posttranslational modification] 395495011570 intermolecular recognition site; other site 395495011571 dimerization interface [polypeptide binding]; other site 395495011572 acyl-CoA synthetase; Validated; Region: PRK08162 395495011573 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 395495011574 acyl-activating enzyme (AAE) consensus motif; other site 395495011575 putative active site [active] 395495011576 AMP binding site [chemical binding]; other site 395495011577 putative CoA binding site [chemical binding]; other site 395495011578 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495011579 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495011580 Walker A/P-loop; other site 395495011581 ATP binding site [chemical binding]; other site 395495011582 Q-loop/lid; other site 395495011583 ABC transporter signature motif; other site 395495011584 Walker B; other site 395495011585 D-loop; other site 395495011586 H-loop/switch region; other site 395495011587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495011588 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495011589 Walker A/P-loop; other site 395495011590 ATP binding site [chemical binding]; other site 395495011591 Q-loop/lid; other site 395495011592 ABC transporter signature motif; other site 395495011593 Walker B; other site 395495011594 D-loop; other site 395495011595 H-loop/switch region; other site 395495011596 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495011597 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 395495011598 putative ligand binding site [chemical binding]; other site 395495011599 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495011600 TM-ABC transporter signature motif; other site 395495011601 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495011602 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495011603 TM-ABC transporter signature motif; other site 395495011604 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395495011605 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 395495011606 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495011607 active site 395495011608 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 395495011609 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 395495011610 dimer interaction site [polypeptide binding]; other site 395495011611 substrate-binding tunnel; other site 395495011612 active site 395495011613 catalytic site [active] 395495011614 substrate binding site [chemical binding]; other site 395495011615 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 395495011616 Ligand binding site [chemical binding]; other site 395495011617 Electron transfer flavoprotein domain; Region: ETF; pfam01012 395495011618 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 395495011619 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 395495011620 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 395495011621 exopolyphosphatase; Region: exo_poly_only; TIGR03706 395495011622 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 395495011623 polyphosphate kinase; Provisional; Region: PRK05443 395495011624 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 395495011625 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 395495011626 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 395495011627 putative domain interface [polypeptide binding]; other site 395495011628 putative active site [active] 395495011629 catalytic site [active] 395495011630 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 395495011631 putative active site [active] 395495011632 catalytic site [active] 395495011633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 395495011634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495011635 Coenzyme A binding pocket [chemical binding]; other site 395495011636 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 395495011637 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 395495011638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 395495011639 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 395495011640 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 395495011641 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 395495011642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495011643 catalytic residue [active] 395495011644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 395495011645 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 395495011646 lysophospholipid transporter LplT; Provisional; Region: PRK11195 395495011647 PhoD-like phosphatase; Region: PhoD; pfam09423 395495011648 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 395495011649 putative active site [active] 395495011650 putative metal binding site [ion binding]; other site 395495011651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395495011652 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 395495011653 putative active site [active] 395495011654 putative metal binding residues [ion binding]; other site 395495011655 signature motif; other site 395495011656 putative triphosphate binding site [ion binding]; other site 395495011657 CHAD domain; Region: CHAD; pfam05235 395495011658 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 395495011659 DctM-like transporters; Region: DctM; pfam06808 395495011660 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 395495011661 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495011662 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495011663 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 395495011664 CPxP motif; other site 395495011665 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 395495011666 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 395495011667 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 395495011668 Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB-like; cd12824 395495011669 Cl binding site [ion binding]; other site 395495011670 oligomer interface [polypeptide binding]; other site 395495011671 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 395495011672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 395495011673 putative active site [active] 395495011674 putative metal binding site [ion binding]; other site 395495011675 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 395495011676 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 395495011677 active site 395495011678 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 395495011679 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 395495011680 Ligand binding site; other site 395495011681 Putative Catalytic site; other site 395495011682 DXD motif; other site 395495011683 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 395495011684 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 395495011685 active site 395495011686 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 395495011687 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 395495011688 active site 395495011689 tetramer interface; other site 395495011690 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395495011691 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 395495011692 NAD binding site [chemical binding]; other site 395495011693 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 395495011694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 395495011695 active site 395495011696 HIGH motif; other site 395495011697 nucleotide binding site [chemical binding]; other site 395495011698 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 395495011699 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 395495011700 active site 395495011701 KMSKS motif; other site 395495011702 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 395495011703 tRNA binding surface [nucleotide binding]; other site 395495011704 anticodon binding site; other site 395495011705 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 395495011706 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 395495011707 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395495011708 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495011709 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 395495011710 putative lipid kinase; Reviewed; Region: PRK13057 395495011711 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 395495011712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495011713 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 395495011714 putative dimerization interface [polypeptide binding]; other site 395495011715 Amidohydrolase; Region: Amidohydro_2; pfam04909 395495011716 hypothetical protein; Provisional; Region: PRK09262 395495011717 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 395495011718 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 395495011719 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 395495011720 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 395495011721 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 395495011722 active site 395495011723 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 395495011724 dimer interface [polypeptide binding]; other site 395495011725 tetramer interface [polypeptide binding]; other site 395495011726 active site 395495011727 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 395495011728 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 395495011729 active site 395495011730 Fe(II) binding site [ion binding]; other site 395495011731 dimer interface [polypeptide binding]; other site 395495011732 tetramer interface [polypeptide binding]; other site 395495011733 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495011734 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495011735 Predicted permeases [General function prediction only]; Region: COG0679 395495011736 Domain of unknown function DUF21; Region: DUF21; pfam01595 395495011737 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 395495011738 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395495011739 Transporter associated domain; Region: CorC_HlyC; smart01091 395495011740 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 395495011741 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495011742 inhibitor-cofactor binding pocket; inhibition site 395495011743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495011744 catalytic residue [active] 395495011745 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 395495011746 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 395495011747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495011748 catalytic residue [active] 395495011749 AAA domain; Region: AAA_26; pfam13500 395495011750 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 395495011751 biotin synthase; Region: bioB; TIGR00433 395495011752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 395495011753 FeS/SAM binding site; other site 395495011754 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 395495011755 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395495011756 Cytochrome P450; Region: p450; cl12078 395495011757 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 395495011758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 395495011759 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 395495011760 putative NAD(P) binding site [chemical binding]; other site 395495011761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495011762 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495011763 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495011764 Walker A/P-loop; other site 395495011765 ATP binding site [chemical binding]; other site 395495011766 Q-loop/lid; other site 395495011767 ABC transporter signature motif; other site 395495011768 Walker B; other site 395495011769 D-loop; other site 395495011770 H-loop/switch region; other site 395495011771 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495011772 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495011773 Walker A/P-loop; other site 395495011774 ATP binding site [chemical binding]; other site 395495011775 Q-loop/lid; other site 395495011776 ABC transporter signature motif; other site 395495011777 Walker B; other site 395495011778 D-loop; other site 395495011779 H-loop/switch region; other site 395495011780 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495011781 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495011782 TM-ABC transporter signature motif; other site 395495011783 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 395495011784 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495011785 TM-ABC transporter signature motif; other site 395495011786 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495011787 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 395495011788 putative ligand binding site [chemical binding]; other site 395495011789 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395495011790 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 395495011791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 395495011792 acyl-activating enzyme (AAE) consensus motif; other site 395495011793 AMP binding site [chemical binding]; other site 395495011794 active site 395495011795 CoA binding site [chemical binding]; other site 395495011796 aldehyde dehydrogenase; Provisional; Region: PRK11903 395495011797 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 395495011798 NAD(P) binding site [chemical binding]; other site 395495011799 catalytic residues [active] 395495011800 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 395495011801 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 395495011802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395495011803 non-specific DNA binding site [nucleotide binding]; other site 395495011804 salt bridge; other site 395495011805 sequence-specific DNA binding site [nucleotide binding]; other site 395495011806 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 395495011807 ADP binding site [chemical binding]; other site 395495011808 magnesium binding site [ion binding]; other site 395495011809 putative shikimate binding site; other site 395495011810 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 395495011811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495011812 substrate binding site [chemical binding]; other site 395495011813 oxyanion hole (OAH) forming residues; other site 395495011814 trimer interface [polypeptide binding]; other site 395495011815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495011816 oxyanion hole (OAH) forming residues; other site 395495011817 trimer interface [polypeptide binding]; other site 395495011818 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 395495011819 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 395495011820 4Fe-4S binding domain; Region: Fer4; pfam00037 395495011821 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 395495011822 FAD binding pocket [chemical binding]; other site 395495011823 conserved FAD binding motif [chemical binding]; other site 395495011824 phosphate binding motif [ion binding]; other site 395495011825 beta-alpha-beta structure motif; other site 395495011826 NAD binding pocket [chemical binding]; other site 395495011827 enoyl-CoA hydratase; Provisional; Region: PRK05995 395495011828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495011829 substrate binding site [chemical binding]; other site 395495011830 oxyanion hole (OAH) forming residues; other site 395495011831 trimer interface [polypeptide binding]; other site 395495011832 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 395495011833 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395495011834 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495011835 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495011836 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 395495011837 putative active site [active] 395495011838 putative catalytic site [active] 395495011839 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 395495011840 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495011841 dimer interface [polypeptide binding]; other site 395495011842 active site 395495011843 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 395495011844 salicylate hydroxylase; Provisional; Region: PRK08163 395495011845 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495011846 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 395495011847 Cupin domain; Region: Cupin_2; pfam07883 395495011848 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 395495011849 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495011850 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 395495011851 maleylacetoacetate isomerase; Region: maiA; TIGR01262 395495011852 C-terminal domain interface [polypeptide binding]; other site 395495011853 GSH binding site (G-site) [chemical binding]; other site 395495011854 putative dimer interface [polypeptide binding]; other site 395495011855 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 395495011856 dimer interface [polypeptide binding]; other site 395495011857 N-terminal domain interface [polypeptide binding]; other site 395495011858 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 395495011859 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 395495011860 DctM-like transporters; Region: DctM; pfam06808 395495011861 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 395495011862 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495011863 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495011864 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 395495011865 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 395495011866 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 395495011867 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 395495011868 FOG: CBS domain [General function prediction only]; Region: COG0517 395495011869 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 395495011870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495011871 catalytic core [active] 395495011872 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 395495011873 putative active site [active] 395495011874 putative metal binding site [ion binding]; other site 395495011875 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 395495011876 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 395495011877 Predicted oxidoreductase [General function prediction only]; Region: COG3573 395495011878 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 395495011879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495011880 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495011881 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 395495011882 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 395495011883 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 395495011884 shikimate binding site; other site 395495011885 NAD(P) binding site [chemical binding]; other site 395495011886 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495011887 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 395495011888 ligand binding site [chemical binding]; other site 395495011889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495011890 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 395495011891 TM-ABC transporter signature motif; other site 395495011892 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 395495011893 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 395495011894 TM-ABC transporter signature motif; other site 395495011895 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 395495011896 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 395495011897 Walker A/P-loop; other site 395495011898 ATP binding site [chemical binding]; other site 395495011899 Q-loop/lid; other site 395495011900 ABC transporter signature motif; other site 395495011901 Walker B; other site 395495011902 D-loop; other site 395495011903 H-loop/switch region; other site 395495011904 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 395495011905 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 395495011906 Walker A/P-loop; other site 395495011907 ATP binding site [chemical binding]; other site 395495011908 Q-loop/lid; other site 395495011909 ABC transporter signature motif; other site 395495011910 Walker B; other site 395495011911 D-loop; other site 395495011912 H-loop/switch region; other site 395495011913 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 395495011914 dimer interface [polypeptide binding]; other site 395495011915 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 395495011916 active site 395495011917 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 395495011918 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 395495011919 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 395495011920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495011921 active site 395495011922 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495011923 catalytic tetrad [active] 395495011924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495011925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495011926 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 395495011927 substrate binding pocket [chemical binding]; other site 395495011928 dimerization interface [polypeptide binding]; other site 395495011929 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 395495011930 putative dimer interface [polypeptide binding]; other site 395495011931 putative tetramer interface [polypeptide binding]; other site 395495011932 putative active site [active] 395495011933 protocatechuate 4,5-dioxygenase subunit beta; Provisional; Region: PRK13364 395495011934 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 395495011935 active site 395495011936 metal binding site [ion binding]; metal-binding site 395495011937 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395495011938 putative catalytic site [active] 395495011939 putative metal binding site [ion binding]; other site 395495011940 putative phosphate binding site [ion binding]; other site 395495011941 AMP nucleosidase; Provisional; Region: PRK08292 395495011942 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 395495011943 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 395495011944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495011945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011946 active site 395495011947 phosphorylation site [posttranslational modification] 395495011948 intermolecular recognition site; other site 395495011949 dimerization interface [polypeptide binding]; other site 395495011950 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011952 active site 395495011953 phosphorylation site [posttranslational modification] 395495011954 intermolecular recognition site; other site 395495011955 dimerization interface [polypeptide binding]; other site 395495011956 PAS domain S-box; Region: sensory_box; TIGR00229 395495011957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495011958 putative active site [active] 395495011959 heme pocket [chemical binding]; other site 395495011960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495011961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495011962 metal binding site [ion binding]; metal-binding site 395495011963 active site 395495011964 I-site; other site 395495011965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495011966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495011967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495011968 dimer interface [polypeptide binding]; other site 395495011969 phosphorylation site [posttranslational modification] 395495011970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495011971 ATP binding site [chemical binding]; other site 395495011972 Mg2+ binding site [ion binding]; other site 395495011973 G-X-G motif; other site 395495011974 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011976 active site 395495011977 phosphorylation site [posttranslational modification] 395495011978 intermolecular recognition site; other site 395495011979 dimerization interface [polypeptide binding]; other site 395495011980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495011981 Response regulator receiver domain; Region: Response_reg; pfam00072 395495011982 active site 395495011983 phosphorylation site [posttranslational modification] 395495011984 intermolecular recognition site; other site 395495011985 dimerization interface [polypeptide binding]; other site 395495011986 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 395495011987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 395495011988 substrate binding pocket [chemical binding]; other site 395495011989 membrane-bound complex binding site; other site 395495011990 hinge residues; other site 395495011991 Protein of unknown function, DUF; Region: DUF411; cl01142 395495011992 Peptidase family M48; Region: Peptidase_M48; cl12018 395495011993 Peptidase family M48; Region: Peptidase_M48; cl12018 395495011994 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 395495011995 macrolide transporter subunit MacA; Provisional; Region: PRK11578 395495011996 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495011997 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395495011998 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495011999 Walker A/P-loop; other site 395495012000 ATP binding site [chemical binding]; other site 395495012001 Q-loop/lid; other site 395495012002 ABC transporter signature motif; other site 395495012003 Walker B; other site 395495012004 D-loop; other site 395495012005 H-loop/switch region; other site 395495012006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395495012007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395495012008 FtsX-like permease family; Region: FtsX; pfam02687 395495012009 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 395495012010 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 395495012011 active site residue [active] 395495012012 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 395495012013 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 395495012014 Protein export membrane protein; Region: SecD_SecF; cl14618 395495012015 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495012016 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495012017 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495012019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495012020 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 395495012021 Uncharacterized conserved protein [Function unknown]; Region: COG3339 395495012022 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 395495012023 putative hydrophobic ligand binding site [chemical binding]; other site 395495012024 Cupin domain; Region: Cupin_2; cl17218 395495012025 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 395495012026 elongation factor G; Reviewed; Region: PRK12740 395495012027 G1 box; other site 395495012028 putative GEF interaction site [polypeptide binding]; other site 395495012029 GTP/Mg2+ binding site [chemical binding]; other site 395495012030 Switch I region; other site 395495012031 G2 box; other site 395495012032 G3 box; other site 395495012033 Switch II region; other site 395495012034 G4 box; other site 395495012035 G5 box; other site 395495012036 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395495012037 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395495012038 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395495012039 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 395495012040 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 395495012041 putative ligand binding site [chemical binding]; other site 395495012042 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 395495012043 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 395495012044 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 395495012045 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 395495012046 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 395495012047 [4Fe-4S] binding site [ion binding]; other site 395495012048 molybdopterin cofactor binding site; other site 395495012049 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 395495012050 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 395495012051 molybdopterin cofactor binding site; other site 395495012052 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 395495012053 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 395495012054 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 395495012055 4Fe-4S binding domain; Region: Fer4; pfam00037 395495012056 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 395495012057 4Fe-4S binding domain; Region: Fer4; pfam00037 395495012058 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 395495012059 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 395495012060 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 395495012061 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 395495012062 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 395495012063 GTP binding site; other site 395495012064 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495012065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012066 active site 395495012067 phosphorylation site [posttranslational modification] 395495012068 intermolecular recognition site; other site 395495012069 dimerization interface [polypeptide binding]; other site 395495012070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495012071 Walker A motif; other site 395495012072 ATP binding site [chemical binding]; other site 395495012073 Walker B motif; other site 395495012074 arginine finger; other site 395495012075 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495012076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495012077 dimerization interface [polypeptide binding]; other site 395495012078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495012079 dimer interface [polypeptide binding]; other site 395495012080 phosphorylation site [posttranslational modification] 395495012081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012082 ATP binding site [chemical binding]; other site 395495012083 G-X-G motif; other site 395495012084 Outer membrane efflux protein; Region: OEP; pfam02321 395495012085 Outer membrane efflux protein; Region: OEP; pfam02321 395495012086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495012087 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012088 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012089 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012090 Ca2+ binding site [ion binding]; other site 395495012091 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012092 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012093 Ca2+ binding site [ion binding]; other site 395495012094 LVIVD repeat; Region: LVIVD; pfam08309 395495012095 LVIVD repeat; Region: LVIVD; pfam08309 395495012096 LVIVD repeat; Region: LVIVD; pfam08309 395495012097 LVIVD repeat; Region: LVIVD; pfam08309 395495012098 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 395495012099 Ca2+ binding site [ion binding]; other site 395495012100 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012101 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012102 Ca2+ binding site [ion binding]; other site 395495012103 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012104 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012105 Ca2+ binding site [ion binding]; other site 395495012106 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012107 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012108 Ca2+ binding site [ion binding]; other site 395495012109 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012110 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012111 Ca2+ binding site [ion binding]; other site 395495012112 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012113 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012114 Ca2+ binding site [ion binding]; other site 395495012115 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012116 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012117 Ca2+ binding site [ion binding]; other site 395495012118 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012119 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012120 Ca2+ binding site [ion binding]; other site 395495012121 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012122 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012123 Ca2+ binding site [ion binding]; other site 395495012124 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012125 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012126 Ca2+ binding site [ion binding]; other site 395495012127 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012128 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012129 Ca2+ binding site [ion binding]; other site 395495012130 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012131 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012132 Ca2+ binding site [ion binding]; other site 395495012133 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012134 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012135 Ca2+ binding site [ion binding]; other site 395495012136 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012137 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012138 Ca2+ binding site [ion binding]; other site 395495012139 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012140 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012141 Ca2+ binding site [ion binding]; other site 395495012142 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012143 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012144 Ca2+ binding site [ion binding]; other site 395495012145 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012146 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012147 Ca2+ binding site [ion binding]; other site 395495012148 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012149 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012150 Ca2+ binding site [ion binding]; other site 395495012151 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012152 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012153 Ca2+ binding site [ion binding]; other site 395495012154 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012155 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012156 Ca2+ binding site [ion binding]; other site 395495012157 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 395495012158 Cadherin repeat-like domain; Region: CA_like; cl15786 395495012159 Ca2+ binding site [ion binding]; other site 395495012160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495012161 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012162 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 395495012163 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 395495012164 active site 395495012165 active site 395495012166 putative substrate binding region [chemical binding]; other site 395495012167 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495012168 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012169 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 395495012170 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 395495012171 active site 395495012172 purine riboside binding site [chemical binding]; other site 395495012173 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495012174 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495012175 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012176 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395495012177 Protein export membrane protein; Region: SecD_SecF; cl14618 395495012178 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 395495012179 Uncharacterized family 4; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_4; cd10161 395495012180 putative homodimer interface [polypeptide binding]; other site 395495012181 putative homotetramer interface [polypeptide binding]; other site 395495012182 putative metal binding site [ion binding]; other site 395495012183 putative homodimer-homodimer interface [polypeptide binding]; other site 395495012184 OsmC-like protein; Region: OsmC; pfam02566 395495012185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395495012186 dimerization interface [polypeptide binding]; other site 395495012187 putative DNA binding site [nucleotide binding]; other site 395495012188 putative Zn2+ binding site [ion binding]; other site 395495012189 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 395495012190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 395495012191 motif II; other site 395495012192 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 395495012193 intersubunit interface [polypeptide binding]; other site 395495012194 active site 395495012195 zinc binding site [ion binding]; other site 395495012196 Na+ binding site [ion binding]; other site 395495012197 phosphoglycolate phosphatase; Provisional; Region: PRK13222 395495012198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495012199 motif II; other site 395495012200 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 395495012201 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395495012202 TPP-binding site [chemical binding]; other site 395495012203 dimer interface [polypeptide binding]; other site 395495012204 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395495012205 PYR/PP interface [polypeptide binding]; other site 395495012206 dimer interface [polypeptide binding]; other site 395495012207 TPP binding site [chemical binding]; other site 395495012208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395495012209 phosphoribulokinase; Provisional; Region: PRK15453 395495012210 fructose-1,6-bisphosphatase family protein; Region: PLN02628 395495012211 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 395495012212 AMP binding site [chemical binding]; other site 395495012213 metal binding site [ion binding]; metal-binding site 395495012214 active site 395495012215 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 395495012216 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 395495012217 substrate binding site [chemical binding]; other site 395495012218 hexamer interface [polypeptide binding]; other site 395495012219 metal binding site [ion binding]; metal-binding site 395495012220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495012221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495012222 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 395495012223 putative dimerization interface [polypeptide binding]; other site 395495012224 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 395495012225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395495012226 DNA binding residues [nucleotide binding] 395495012227 Protein of unknown function (DUF445); Region: DUF445; pfam04286 395495012228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495012229 S-adenosylmethionine binding site [chemical binding]; other site 395495012230 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 395495012231 potassium uptake protein; Region: kup; TIGR00794 395495012232 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 395495012233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012234 active site 395495012235 phosphorylation site [posttranslational modification] 395495012236 intermolecular recognition site; other site 395495012237 dimerization interface [polypeptide binding]; other site 395495012238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 395495012239 DNA binding site [nucleotide binding] 395495012240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495012241 dimer interface [polypeptide binding]; other site 395495012242 phosphorylation site [posttranslational modification] 395495012243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012244 ATP binding site [chemical binding]; other site 395495012245 Mg2+ binding site [ion binding]; other site 395495012246 G-X-G motif; other site 395495012247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 395495012248 metal ion-dependent adhesion site (MIDAS); other site 395495012249 MoxR-like ATPases [General function prediction only]; Region: COG0714 395495012250 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 395495012251 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 395495012252 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 395495012253 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 395495012254 dimer interface [polypeptide binding]; other site 395495012255 active site 395495012256 catalytic residue [active] 395495012257 metal binding site [ion binding]; metal-binding site 395495012258 Uncharacterized conserved protein [Function unknown]; Region: COG1262 395495012259 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 395495012260 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395495012261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495012262 catalytic residues [active] 395495012263 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495012264 Cytochrome c; Region: Cytochrom_C; cl11414 395495012265 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 395495012266 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 395495012267 DsrE/DsrF-like family; Region: DrsE; cl00672 395495012268 Sulphur transport; Region: Sulf_transp; pfam04143 395495012269 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 395495012270 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 395495012271 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 395495012272 active site 395495012273 metal binding site [ion binding]; metal-binding site 395495012274 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 395495012275 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 395495012276 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 395495012277 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 395495012278 Cytochrome c; Region: Cytochrom_C; pfam00034 395495012279 Cytochrome c; Region: Cytochrom_C; cl11414 395495012280 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 395495012281 Moco binding site; other site 395495012282 metal coordination site [ion binding]; other site 395495012283 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 395495012284 RNA polymerase sigma factor; Provisional; Region: PRK12511 395495012285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 395495012286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 395495012287 DNA binding residues [nucleotide binding] 395495012288 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 395495012289 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 395495012290 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 395495012291 gating phenylalanine in ion channel; other site 395495012292 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 395495012293 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495012294 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495012295 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495012296 Cu(I) binding site [ion binding]; other site 395495012297 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 395495012298 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 395495012299 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 395495012300 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 395495012301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495012302 dimer interface [polypeptide binding]; other site 395495012303 putative CheW interface [polypeptide binding]; other site 395495012304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012305 Response regulator receiver domain; Region: Response_reg; pfam00072 395495012306 active site 395495012307 phosphorylation site [posttranslational modification] 395495012308 intermolecular recognition site; other site 395495012309 dimerization interface [polypeptide binding]; other site 395495012310 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 395495012311 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 395495012312 anti sigma factor interaction site; other site 395495012313 regulatory phosphorylation site [posttranslational modification]; other site 395495012314 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395495012315 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495012316 putative binding surface; other site 395495012317 active site 395495012318 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395495012319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012320 ATP binding site [chemical binding]; other site 395495012321 Mg2+ binding site [ion binding]; other site 395495012322 G-X-G motif; other site 395495012323 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 395495012324 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 395495012325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495012326 dimerization interface [polypeptide binding]; other site 395495012327 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 395495012328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495012329 putative CheW interface [polypeptide binding]; other site 395495012330 dimer interface [polypeptide binding]; other site 395495012331 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 395495012332 putative CheA interaction surface; other site 395495012333 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 395495012334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012335 phosphorylation site [posttranslational modification] 395495012336 intermolecular recognition site; other site 395495012337 CheB methylesterase; Region: CheB_methylest; pfam01339 395495012338 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 395495012339 Predicted transporter component [General function prediction only]; Region: COG2391 395495012340 Sulphur transport; Region: Sulf_transp; pfam04143 395495012341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495012342 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 395495012343 substrate binding pocket [chemical binding]; other site 395495012344 membrane-bound complex binding site; other site 395495012345 hinge residues; other site 395495012346 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 395495012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495012348 dimer interface [polypeptide binding]; other site 395495012349 conserved gate region; other site 395495012350 putative PBP binding loops; other site 395495012351 ABC-ATPase subunit interface; other site 395495012352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495012353 dimer interface [polypeptide binding]; other site 395495012354 conserved gate region; other site 395495012355 putative PBP binding loops; other site 395495012356 ABC-ATPase subunit interface; other site 395495012357 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 395495012358 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 395495012359 Walker A/P-loop; other site 395495012360 ATP binding site [chemical binding]; other site 395495012361 Q-loop/lid; other site 395495012362 ABC transporter signature motif; other site 395495012363 Walker B; other site 395495012364 D-loop; other site 395495012365 H-loop/switch region; other site 395495012366 TOBE-like domain; Region: TOBE_3; pfam12857 395495012367 TIR domain; Region: TIR_2; pfam13676 395495012368 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395495012369 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395495012370 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 395495012371 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 395495012372 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 395495012373 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 395495012374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495012375 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 395495012376 substrate binding site [chemical binding]; other site 395495012377 dimerization interface [polypeptide binding]; other site 395495012378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395495012379 catalytic residues [active] 395495012380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495012381 catalytic core [active] 395495012382 preprotein translocase subunit SecB; Validated; Region: PRK05751 395495012383 SecA binding site; other site 395495012384 Preprotein binding site; other site 395495012385 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 395495012386 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 395495012387 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 395495012388 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 395495012389 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 395495012390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495012391 active site 395495012392 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 395495012393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495012394 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 395495012395 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 395495012396 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 395495012397 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495012398 Cytochrome c; Region: Cytochrom_C; pfam00034 395495012399 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 395495012400 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 395495012401 Subunit I/III interface [polypeptide binding]; other site 395495012402 D-pathway; other site 395495012403 Subunit I/VIIc interface [polypeptide binding]; other site 395495012404 Subunit I/IV interface [polypeptide binding]; other site 395495012405 Subunit I/II interface [polypeptide binding]; other site 395495012406 Low-spin heme (heme a) binding site [chemical binding]; other site 395495012407 Subunit I/VIIa interface [polypeptide binding]; other site 395495012408 Subunit I/VIa interface [polypeptide binding]; other site 395495012409 Dimer interface; other site 395495012410 Putative water exit pathway; other site 395495012411 Binuclear center (heme a3/CuB) [ion binding]; other site 395495012412 K-pathway; other site 395495012413 Subunit I/Vb interface [polypeptide binding]; other site 395495012414 Putative proton exit pathway; other site 395495012415 Subunit I/VIb interface; other site 395495012416 Subunit I/VIc interface [polypeptide binding]; other site 395495012417 Electron transfer pathway; other site 395495012418 Subunit I/VIIIb interface [polypeptide binding]; other site 395495012419 Subunit I/VIIb interface [polypeptide binding]; other site 395495012420 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 395495012421 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 395495012422 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 395495012423 Subunit III/VIIa interface [polypeptide binding]; other site 395495012424 Phospholipid binding site [chemical binding]; other site 395495012425 Subunit I/III interface [polypeptide binding]; other site 395495012426 Subunit III/VIb interface [polypeptide binding]; other site 395495012427 Subunit III/VIa interface; other site 395495012428 Subunit III/Vb interface [polypeptide binding]; other site 395495012429 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 395495012430 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 395495012431 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 395495012432 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 395495012433 UbiA prenyltransferase family; Region: UbiA; pfam01040 395495012434 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495012435 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495012436 Cu(I) binding site [ion binding]; other site 395495012437 ABC transporter ATPase component; Reviewed; Region: PRK11147 395495012438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495012439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495012440 ABC transporter; Region: ABC_tran_2; pfam12848 395495012441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 395495012442 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495012443 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495012444 ligand binding site [chemical binding]; other site 395495012445 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 395495012446 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 395495012447 putative active site [active] 395495012448 catalytic triad [active] 395495012449 putative dimer interface [polypeptide binding]; other site 395495012450 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 395495012451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 395495012452 Transporter associated domain; Region: CorC_HlyC; smart01091 395495012453 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 395495012454 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 395495012455 P-loop, Walker A motif; other site 395495012456 Base recognition motif; other site 395495012457 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 395495012458 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 395495012459 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 395495012460 active site 395495012461 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 395495012462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495012463 Walker A motif; other site 395495012464 ATP binding site [chemical binding]; other site 395495012465 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 395495012466 Walker B motif; other site 395495012467 arginine finger; other site 395495012468 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 395495012469 pantothenate kinase; Reviewed; Region: PRK13329 395495012470 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 395495012471 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 395495012472 Walker A/P-loop; other site 395495012473 ATP binding site [chemical binding]; other site 395495012474 Q-loop/lid; other site 395495012475 ABC transporter signature motif; other site 395495012476 Walker B; other site 395495012477 D-loop; other site 395495012478 H-loop/switch region; other site 395495012479 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 395495012480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495012481 dimer interface [polypeptide binding]; other site 395495012482 conserved gate region; other site 395495012483 putative PBP binding loops; other site 395495012484 ABC-ATPase subunit interface; other site 395495012485 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 395495012486 NMT1-like family; Region: NMT1_2; pfam13379 395495012487 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 395495012488 B12 binding site [chemical binding]; other site 395495012489 cobalt ligand [ion binding]; other site 395495012490 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 395495012491 Walker A; other site 395495012492 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 395495012493 putative active site [active] 395495012494 putative substrate binding site [chemical binding]; other site 395495012495 putative coenzyme B12 binding site [chemical binding]; other site 395495012496 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495012497 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 395495012498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 395495012499 LabA_like proteins; Region: LabA_like; cd06167 395495012500 putative metal binding site [ion binding]; other site 395495012501 Uncharacterized conserved protein [Function unknown]; Region: COG1432 395495012502 Histidine kinase; Region: HisKA_3; pfam07730 395495012503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495012504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012505 active site 395495012506 phosphorylation site [posttranslational modification] 395495012507 intermolecular recognition site; other site 395495012508 dimerization interface [polypeptide binding]; other site 395495012509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495012510 DNA binding residues [nucleotide binding] 395495012511 dimerization interface [polypeptide binding]; other site 395495012512 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 395495012513 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495012514 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495012515 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495012516 putative cation:proton antiport protein; Provisional; Region: PRK10669 395495012517 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 395495012518 TrkA-N domain; Region: TrkA_N; pfam02254 395495012519 beta-ketothiolase; Provisional; Region: PRK09051 395495012520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495012521 dimer interface [polypeptide binding]; other site 395495012522 active site 395495012523 PEGA domain; Region: PEGA; pfam08308 395495012524 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 395495012525 YaeQ protein; Region: YaeQ; pfam07152 395495012526 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 395495012527 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 395495012528 G1 box; other site 395495012529 putative GEF interaction site [polypeptide binding]; other site 395495012530 GTP/Mg2+ binding site [chemical binding]; other site 395495012531 Switch I region; other site 395495012532 G2 box; other site 395495012533 G3 box; other site 395495012534 Switch II region; other site 395495012535 G4 box; other site 395495012536 G5 box; other site 395495012537 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 395495012538 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 395495012539 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 395495012540 active site 395495012541 substrate binding site [chemical binding]; other site 395495012542 FMN binding site [chemical binding]; other site 395495012543 putative catalytic residues [active] 395495012544 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 395495012545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495012546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495012547 dimerization interface [polypeptide binding]; other site 395495012548 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 395495012549 S17 interaction site [polypeptide binding]; other site 395495012550 S8 interaction site; other site 395495012551 16S rRNA interaction site [nucleotide binding]; other site 395495012552 streptomycin interaction site [chemical binding]; other site 395495012553 23S rRNA interaction site [nucleotide binding]; other site 395495012554 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 395495012555 30S ribosomal protein S7; Validated; Region: PRK05302 395495012556 elongation factor G; Reviewed; Region: PRK00007 395495012557 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 395495012558 G1 box; other site 395495012559 putative GEF interaction site [polypeptide binding]; other site 395495012560 GTP/Mg2+ binding site [chemical binding]; other site 395495012561 Switch I region; other site 395495012562 G2 box; other site 395495012563 G3 box; other site 395495012564 Switch II region; other site 395495012565 G4 box; other site 395495012566 G5 box; other site 395495012567 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 395495012568 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 395495012569 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 395495012570 elongation factor Tu; Reviewed; Region: PRK00049 395495012571 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 395495012572 G1 box; other site 395495012573 GEF interaction site [polypeptide binding]; other site 395495012574 GTP/Mg2+ binding site [chemical binding]; other site 395495012575 Switch I region; other site 395495012576 G2 box; other site 395495012577 G3 box; other site 395495012578 Switch II region; other site 395495012579 G4 box; other site 395495012580 G5 box; other site 395495012581 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 395495012582 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 395495012583 Antibiotic Binding Site [chemical binding]; other site 395495012584 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 395495012585 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 395495012586 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 395495012587 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 395495012588 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 395495012589 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 395495012590 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 395495012591 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 395495012592 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 395495012593 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 395495012594 DNA binding site [nucleotide binding] 395495012595 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 395495012596 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 395495012597 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 395495012598 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 395495012599 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 395495012600 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 395495012601 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 395495012602 RPB3 interaction site [polypeptide binding]; other site 395495012603 RPB1 interaction site [polypeptide binding]; other site 395495012604 RPB11 interaction site [polypeptide binding]; other site 395495012605 RPB10 interaction site [polypeptide binding]; other site 395495012606 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 395495012607 peripheral dimer interface [polypeptide binding]; other site 395495012608 core dimer interface [polypeptide binding]; other site 395495012609 L10 interface [polypeptide binding]; other site 395495012610 L11 interface [polypeptide binding]; other site 395495012611 putative EF-Tu interaction site [polypeptide binding]; other site 395495012612 putative EF-G interaction site [polypeptide binding]; other site 395495012613 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 395495012614 23S rRNA interface [nucleotide binding]; other site 395495012615 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 395495012616 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 395495012617 mRNA/rRNA interface [nucleotide binding]; other site 395495012618 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 395495012619 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 395495012620 23S rRNA interface [nucleotide binding]; other site 395495012621 L7/L12 interface [polypeptide binding]; other site 395495012622 putative thiostrepton binding site; other site 395495012623 L25 interface [polypeptide binding]; other site 395495012624 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 395495012625 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 395495012626 putative homodimer interface [polypeptide binding]; other site 395495012627 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 395495012628 heterodimer interface [polypeptide binding]; other site 395495012629 homodimer interface [polypeptide binding]; other site 395495012630 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 395495012631 elongation factor Tu; Reviewed; Region: PRK00049 395495012632 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 395495012633 G1 box; other site 395495012634 GEF interaction site [polypeptide binding]; other site 395495012635 GTP/Mg2+ binding site [chemical binding]; other site 395495012636 Switch I region; other site 395495012637 G2 box; other site 395495012638 G3 box; other site 395495012639 Switch II region; other site 395495012640 G4 box; other site 395495012641 G5 box; other site 395495012642 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 395495012643 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 395495012644 Antibiotic Binding Site [chemical binding]; other site 395495012645 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 395495012646 ligand binding site [chemical binding]; other site 395495012647 active site 395495012648 UGI interface [polypeptide binding]; other site 395495012649 catalytic site [active] 395495012650 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 395495012651 active site 395495012652 substrate (anthranilate) binding pocket [chemical binding]; other site 395495012653 product (indole) binding pocket [chemical binding]; other site 395495012654 ribulose/triose binding site [chemical binding]; other site 395495012655 phosphate binding site [ion binding]; other site 395495012656 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 395495012657 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 395495012658 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 395495012659 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 395495012660 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 395495012661 glutamine binding [chemical binding]; other site 395495012662 catalytic triad [active] 395495012663 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 395495012664 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495012665 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 395495012666 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 395495012667 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 395495012668 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 395495012669 Walker A motif; other site 395495012670 ATP binding site [chemical binding]; other site 395495012671 Walker B motif; other site 395495012672 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 395495012673 Secretin and TonB N terminus short domain; Region: STN; smart00965 395495012674 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 395495012675 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 395495012676 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 395495012677 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 395495012678 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 395495012679 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 395495012680 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 395495012681 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 395495012682 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 395495012683 SurA N-terminal domain; Region: SurA_N_3; cl07813 395495012684 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495012685 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495012686 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495012687 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495012688 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495012689 Cu(I) binding site [ion binding]; other site 395495012690 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 395495012691 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 395495012692 Cu(I) binding site [ion binding]; other site 395495012693 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 395495012694 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495012695 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 395495012696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495012697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 395495012698 dimer interface [polypeptide binding]; other site 395495012699 phosphorylation site [posttranslational modification] 395495012700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012701 ATP binding site [chemical binding]; other site 395495012702 Mg2+ binding site [ion binding]; other site 395495012703 G-X-G motif; other site 395495012704 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 395495012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012706 active site 395495012707 phosphorylation site [posttranslational modification] 395495012708 intermolecular recognition site; other site 395495012709 dimerization interface [polypeptide binding]; other site 395495012710 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495012711 4-alpha-glucanotransferase; Provisional; Region: PRK14508 395495012712 anthranilate synthase component I; Provisional; Region: PRK13565 395495012713 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 395495012714 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 395495012715 phosphoglycolate phosphatase; Provisional; Region: PRK13222 395495012716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495012717 motif II; other site 395495012718 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 395495012719 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 395495012720 substrate binding site [chemical binding]; other site 395495012721 hexamer interface [polypeptide binding]; other site 395495012722 metal binding site [ion binding]; metal-binding site 395495012723 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 395495012724 Site-specific recombinase; Region: SpecificRecomb; pfam10136 395495012725 MltA specific insert domain; Region: MltA; smart00925 395495012726 3D domain; Region: 3D; pfam06725 395495012727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495012728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495012729 metal binding site [ion binding]; metal-binding site 395495012730 active site 395495012731 I-site; other site 395495012732 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 395495012733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 395495012734 putative DNA binding site [nucleotide binding]; other site 395495012735 putative Zn2+ binding site [ion binding]; other site 395495012736 AsnC family; Region: AsnC_trans_reg; pfam01037 395495012737 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 395495012738 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 395495012739 dimer interface [polypeptide binding]; other site 395495012740 PYR/PP interface [polypeptide binding]; other site 395495012741 TPP binding site [chemical binding]; other site 395495012742 substrate binding site [chemical binding]; other site 395495012743 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 395495012744 TPP-binding site; other site 395495012745 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 395495012746 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 395495012747 rRNA binding site [nucleotide binding]; other site 395495012748 predicted 30S ribosome binding site; other site 395495012749 glutathione synthetase; Provisional; Region: PRK05246 395495012750 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 395495012751 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 395495012752 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 395495012753 Phosphotransferase enzyme family; Region: APH; pfam01636 395495012754 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 395495012755 Organic solvent tolerance protein; Region: OstA_C; pfam04453 395495012756 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 395495012757 SurA N-terminal domain; Region: SurA_N; pfam09312 395495012758 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495012759 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495012760 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 395495012761 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 395495012762 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 395495012763 putative RNAase interaction site [polypeptide binding]; other site 395495012764 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 395495012765 active site 395495012766 barstar interaction site; other site 395495012767 malic enzyme; Reviewed; Region: PRK12862 395495012768 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 395495012769 Malic enzyme, N-terminal domain; Region: malic; pfam00390 395495012770 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 395495012771 putative NAD(P) binding site [chemical binding]; other site 395495012772 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 395495012773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495012774 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 395495012775 putative active site [active] 395495012776 heme pocket [chemical binding]; other site 395495012777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495012778 dimer interface [polypeptide binding]; other site 395495012779 phosphorylation site [posttranslational modification] 395495012780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012781 ATP binding site [chemical binding]; other site 395495012782 Mg2+ binding site [ion binding]; other site 395495012783 G-X-G motif; other site 395495012784 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 395495012785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012786 active site 395495012787 phosphorylation site [posttranslational modification] 395495012788 intermolecular recognition site; other site 395495012789 dimerization interface [polypeptide binding]; other site 395495012790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495012791 DNA binding residues [nucleotide binding] 395495012792 dimerization interface [polypeptide binding]; other site 395495012793 thiamine monophosphate kinase; Provisional; Region: PRK05731 395495012794 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 395495012795 ATP binding site [chemical binding]; other site 395495012796 dimerization interface [polypeptide binding]; other site 395495012797 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 395495012798 tetramer interfaces [polypeptide binding]; other site 395495012799 binuclear metal-binding site [ion binding]; other site 395495012800 Competence-damaged protein; Region: CinA; pfam02464 395495012801 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 395495012802 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 395495012803 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 395495012804 alphaNTD homodimer interface [polypeptide binding]; other site 395495012805 alphaNTD - beta interaction site [polypeptide binding]; other site 395495012806 alphaNTD - beta' interaction site [polypeptide binding]; other site 395495012807 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 395495012808 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 395495012809 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 395495012810 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495012811 RNA binding surface [nucleotide binding]; other site 395495012812 30S ribosomal protein S11; Validated; Region: PRK05309 395495012813 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 395495012814 30S ribosomal protein S13; Region: bact_S13; TIGR03631 395495012815 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 395495012816 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 395495012817 rRNA binding site [nucleotide binding]; other site 395495012818 predicted 30S ribosome binding site; other site 395495012819 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 395495012820 SecY translocase; Region: SecY; pfam00344 395495012821 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 395495012822 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 395495012823 23S rRNA binding site [nucleotide binding]; other site 395495012824 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 395495012825 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 395495012826 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 395495012827 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 395495012828 5S rRNA interface [nucleotide binding]; other site 395495012829 23S rRNA interface [nucleotide binding]; other site 395495012830 L5 interface [polypeptide binding]; other site 395495012831 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 395495012832 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395495012833 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 395495012834 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 395495012835 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 395495012836 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 395495012837 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 395495012838 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 395495012839 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 395495012840 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 395495012841 RNA binding site [nucleotide binding]; other site 395495012842 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 395495012843 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 395495012844 Glutamate-cysteine ligase; Region: GshA; pfam08886 395495012845 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 395495012846 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 395495012847 Nitrogen regulatory protein P-II; Region: P-II; smart00938 395495012848 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 395495012849 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 395495012850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495012851 Walker A motif; other site 395495012852 ATP binding site [chemical binding]; other site 395495012853 Walker B motif; other site 395495012854 arginine finger; other site 395495012855 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 395495012856 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 395495012857 RNA methyltransferase, RsmE family; Region: TIGR00046 395495012858 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 395495012859 active site 395495012860 substrate-binding site [chemical binding]; other site 395495012861 metal-binding site [ion binding] 395495012862 GTP binding site [chemical binding]; other site 395495012863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495012864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495012865 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 395495012866 dimerization interface [polypeptide binding]; other site 395495012867 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 395495012868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 395495012869 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 395495012870 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 395495012871 PhoH-like protein; Region: PhoH; pfam02562 395495012872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 395495012873 Histidine kinase; Region: HisKA_3; pfam07730 395495012874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012875 ATP binding site [chemical binding]; other site 395495012876 Mg2+ binding site [ion binding]; other site 395495012877 G-X-G motif; other site 395495012878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495012879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012880 active site 395495012881 phosphorylation site [posttranslational modification] 395495012882 intermolecular recognition site; other site 395495012883 dimerization interface [polypeptide binding]; other site 395495012884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495012885 DNA binding residues [nucleotide binding] 395495012886 dimerization interface [polypeptide binding]; other site 395495012887 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 395495012888 RuvA N terminal domain; Region: RuvA_N; pfam01330 395495012889 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 395495012890 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 395495012891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495012892 Walker A motif; other site 395495012893 ATP binding site [chemical binding]; other site 395495012894 Walker B motif; other site 395495012895 arginine finger; other site 395495012896 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 395495012897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495012898 catalytic core [active] 395495012899 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 395495012900 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 395495012901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 395495012902 putative acyl-acceptor binding pocket; other site 395495012903 dihydroorotase; Provisional; Region: PRK07627 395495012904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395495012905 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 395495012906 active site 395495012907 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 395495012908 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 395495012909 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 395495012910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495012911 active site 395495012912 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 395495012913 hypothetical protein; Validated; Region: PRK00228 395495012914 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 395495012915 DNA photolyase; Region: DNA_photolyase; pfam00875 395495012916 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 395495012917 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495012918 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495012919 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 395495012920 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495012921 metal binding site [ion binding]; metal-binding site 395495012922 active site 395495012923 I-site; other site 395495012924 Hpt domain; Region: Hpt; pfam01627 395495012925 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495012926 putative binding surface; other site 395495012927 active site 395495012928 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 395495012929 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495012930 putative binding surface; other site 395495012931 active site 395495012932 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 395495012933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495012934 ATP binding site [chemical binding]; other site 395495012935 Mg2+ binding site [ion binding]; other site 395495012936 G-X-G motif; other site 395495012937 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395495012938 Response regulator receiver domain; Region: Response_reg; pfam00072 395495012939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012940 active site 395495012941 phosphorylation site [posttranslational modification] 395495012942 intermolecular recognition site; other site 395495012943 dimerization interface [polypeptide binding]; other site 395495012944 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 395495012945 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495012946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495012947 dimer interface [polypeptide binding]; other site 395495012948 putative CheW interface [polypeptide binding]; other site 395495012949 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 395495012950 Response regulator receiver domain; Region: Response_reg; pfam00072 395495012951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012952 active site 395495012953 phosphorylation site [posttranslational modification] 395495012954 intermolecular recognition site; other site 395495012955 dimerization interface [polypeptide binding]; other site 395495012956 Response regulator receiver domain; Region: Response_reg; pfam00072 395495012957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495012958 active site 395495012959 phosphorylation site [posttranslational modification] 395495012960 intermolecular recognition site; other site 395495012961 dimerization interface [polypeptide binding]; other site 395495012962 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 395495012963 Rubredoxin; Region: Rubredoxin; pfam00301 395495012964 iron binding site [ion binding]; other site 395495012965 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 395495012966 substrate binding site [chemical binding]; other site 395495012967 ATP binding site [chemical binding]; other site 395495012968 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 395495012969 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 395495012970 inhibitor-cofactor binding pocket; inhibition site 395495012971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495012972 catalytic residue [active] 395495012973 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 395495012974 active site 395495012975 phosphate binding residues; other site 395495012976 catalytic residues [active] 395495012977 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 395495012978 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 395495012979 active site 395495012980 ADP/pyrophosphate binding site [chemical binding]; other site 395495012981 dimerization interface [polypeptide binding]; other site 395495012982 allosteric effector site; other site 395495012983 fructose-1,6-bisphosphate binding site; other site 395495012984 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 395495012985 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 395495012986 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495012987 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495012988 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 395495012989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395495012990 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 395495012991 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 395495012992 NAD(P) binding site [chemical binding]; other site 395495012993 homotetramer interface [polypeptide binding]; other site 395495012994 homodimer interface [polypeptide binding]; other site 395495012995 active site 395495012996 Exoribonuclease R [Transcription]; Region: VacB; COG0557 395495012997 RNB domain; Region: RNB; pfam00773 395495012998 Transglycosylase; Region: Transgly; cl17702 395495012999 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395495013000 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495013001 catalytic residues [active] 395495013002 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 395495013003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 395495013004 carboxyltransferase (CT) interaction site; other site 395495013005 biotinylation site [posttranslational modification]; other site 395495013006 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 395495013007 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 395495013008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 395495013009 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 395495013010 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 395495013011 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 395495013012 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 395495013013 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 395495013014 catalytic triad [active] 395495013015 dimer interface [polypeptide binding]; other site 395495013016 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 395495013017 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 395495013018 23S rRNA interface [nucleotide binding]; other site 395495013019 putative translocon interaction site; other site 395495013020 signal recognition particle (SRP54) interaction site; other site 395495013021 L23 interface [polypeptide binding]; other site 395495013022 trigger factor interaction site; other site 395495013023 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 395495013024 23S rRNA interface [nucleotide binding]; other site 395495013025 5S rRNA interface [nucleotide binding]; other site 395495013026 putative antibiotic binding site [chemical binding]; other site 395495013027 L25 interface [polypeptide binding]; other site 395495013028 L27 interface [polypeptide binding]; other site 395495013029 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 395495013030 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 395495013031 G-X-X-G motif; other site 395495013032 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 395495013033 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 395495013034 putative translocon binding site; other site 395495013035 protein-rRNA interface [nucleotide binding]; other site 395495013036 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 395495013037 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 395495013038 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 395495013039 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 395495013040 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 395495013041 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 395495013042 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 395495013043 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013045 active site 395495013046 phosphorylation site [posttranslational modification] 395495013047 intermolecular recognition site; other site 395495013048 dimerization interface [polypeptide binding]; other site 395495013049 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 395495013050 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 395495013051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495013052 dimerization interface [polypeptide binding]; other site 395495013053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013054 dimer interface [polypeptide binding]; other site 395495013055 phosphorylation site [posttranslational modification] 395495013056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013057 ATP binding site [chemical binding]; other site 395495013058 Mg2+ binding site [ion binding]; other site 395495013059 G-X-G motif; other site 395495013060 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 395495013061 16S rRNA methyltransferase B; Provisional; Region: PRK10901 395495013062 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 395495013063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495013064 S-adenosylmethionine binding site [chemical binding]; other site 395495013065 LemA family; Region: LemA; cl00742 395495013066 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 395495013067 Ligand Binding Site [chemical binding]; other site 395495013068 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 395495013069 putative catalytic cysteine [active] 395495013070 UDP-glucose 4-epimerase; Region: PLN02240 395495013071 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 395495013072 NAD binding site [chemical binding]; other site 395495013073 homodimer interface [polypeptide binding]; other site 395495013074 active site 395495013075 substrate binding site [chemical binding]; other site 395495013076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 395495013077 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 395495013078 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 395495013079 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 395495013080 Uncharacterized conserved protein [Function unknown]; Region: COG2928 395495013081 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 395495013082 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 395495013083 dimer interface [polypeptide binding]; other site 395495013084 anticodon binding site; other site 395495013085 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 395495013086 homodimer interface [polypeptide binding]; other site 395495013087 motif 1; other site 395495013088 active site 395495013089 motif 2; other site 395495013090 GAD domain; Region: GAD; pfam02938 395495013091 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 395495013092 motif 3; other site 395495013093 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 395495013094 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 395495013095 nudix motif; other site 395495013096 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 395495013097 putative catalytic site [active] 395495013098 putative metal binding site [ion binding]; other site 395495013099 putative phosphate binding site [ion binding]; other site 395495013100 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 395495013101 putative active site [active] 395495013102 catalytic site [active] 395495013103 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 395495013104 PLD-like domain; Region: PLDc_2; pfam13091 395495013105 putative active site [active] 395495013106 catalytic site [active] 395495013107 heat shock protein HtpX; Provisional; Region: PRK05457 395495013108 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 395495013109 active site 395495013110 substrate binding pocket [chemical binding]; other site 395495013111 dimer interface [polypeptide binding]; other site 395495013112 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 395495013113 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 395495013114 Walker A/P-loop; other site 395495013115 ATP binding site [chemical binding]; other site 395495013116 Q-loop/lid; other site 395495013117 ABC transporter signature motif; other site 395495013118 Walker B; other site 395495013119 D-loop; other site 395495013120 H-loop/switch region; other site 395495013121 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 395495013122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495013123 dimer interface [polypeptide binding]; other site 395495013124 conserved gate region; other site 395495013125 putative PBP binding loops; other site 395495013126 ABC-ATPase subunit interface; other site 395495013127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495013128 dimer interface [polypeptide binding]; other site 395495013129 conserved gate region; other site 395495013130 putative PBP binding loops; other site 395495013131 ABC-ATPase subunit interface; other site 395495013132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 395495013133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 395495013134 substrate binding pocket [chemical binding]; other site 395495013135 membrane-bound complex binding site; other site 395495013136 hinge residues; other site 395495013137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495013138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 395495013139 dimerization interface [polypeptide binding]; other site 395495013140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495013141 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 395495013142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495013143 Walker A/P-loop; other site 395495013144 ATP binding site [chemical binding]; other site 395495013145 Q-loop/lid; other site 395495013146 ABC transporter signature motif; other site 395495013147 Walker B; other site 395495013148 D-loop; other site 395495013149 H-loop/switch region; other site 395495013150 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 395495013151 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 395495013152 active site 395495013153 catalytic triad [active] 395495013154 enoyl-CoA hydratase; Provisional; Region: PRK06688 395495013155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495013156 substrate binding site [chemical binding]; other site 395495013157 oxyanion hole (OAH) forming residues; other site 395495013158 trimer interface [polypeptide binding]; other site 395495013159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 395495013160 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 395495013161 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495013162 dimer interface [polypeptide binding]; other site 395495013163 active site 395495013164 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 395495013165 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 395495013166 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 395495013167 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 395495013168 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 395495013169 substrate binding site [chemical binding]; other site 395495013170 oxyanion hole (OAH) forming residues; other site 395495013171 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 395495013172 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 395495013173 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495013174 active site 395495013175 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 395495013176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 395495013177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 395495013178 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 395495013179 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 395495013180 active site 395495013181 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 395495013182 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 395495013183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 395495013184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495013185 Walker A/P-loop; other site 395495013186 ATP binding site [chemical binding]; other site 395495013187 Q-loop/lid; other site 395495013188 ABC transporter signature motif; other site 395495013189 Walker B; other site 395495013190 D-loop; other site 395495013191 H-loop/switch region; other site 395495013192 cyanophycin synthetase; Provisional; Region: PRK14016 395495013193 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 395495013194 cyanophycin synthetase; Provisional; Region: PRK14016 395495013195 ATP-grasp domain; Region: ATP-grasp_4; cl17255 395495013196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 395495013197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 395495013198 Predicted metalloprotease [General function prediction only]; Region: COG2321 395495013199 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 395495013200 Nitrate and nitrite sensing; Region: NIT; pfam08376 395495013201 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495013202 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495013203 dimer interface [polypeptide binding]; other site 395495013204 putative CheW interface [polypeptide binding]; other site 395495013205 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 395495013206 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 395495013207 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 395495013208 catalytic residues [active] 395495013209 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 395495013210 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 395495013211 GatB domain; Region: GatB_Yqey; smart00845 395495013212 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 395495013213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 395495013214 active site 395495013215 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 395495013216 putative active site [active] 395495013217 putative catalytic site [active] 395495013218 putative DNA binding site [nucleotide binding]; other site 395495013219 putative phosphate binding site [ion binding]; other site 395495013220 metal binding site A [ion binding]; metal-binding site 395495013221 putative AP binding site [nucleotide binding]; other site 395495013222 putative metal binding site B [ion binding]; other site 395495013223 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 395495013224 phosphate binding site [ion binding]; other site 395495013225 putative substrate binding pocket [chemical binding]; other site 395495013226 dimer interface [polypeptide binding]; other site 395495013227 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395495013228 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 395495013229 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 395495013230 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 395495013231 hypothetical protein; Provisional; Region: PRK07033 395495013232 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 395495013233 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495013234 ligand binding site [chemical binding]; other site 395495013235 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 395495013236 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 395495013237 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 395495013238 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 395495013239 Protein kinase domain; Region: Pkinase; pfam00069 395495013240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 395495013241 active site 395495013242 ATP binding site [chemical binding]; other site 395495013243 substrate binding site [chemical binding]; other site 395495013244 activation loop (A-loop); other site 395495013245 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 395495013246 Peptidase M15; Region: Peptidase_M15_3; pfam08291 395495013247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 395495013248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495013249 active site 395495013250 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495013251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495013252 ligand binding site [chemical binding]; other site 395495013253 active site 395495013254 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 395495013255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 395495013256 phosphopeptide binding site; other site 395495013257 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495013258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495013259 active site 395495013260 ATP binding site [chemical binding]; other site 395495013261 substrate binding site [chemical binding]; other site 395495013262 activation loop (A-loop); other site 395495013263 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 395495013264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495013265 dimerization interface [polypeptide binding]; other site 395495013266 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 395495013267 PAS domain S-box; Region: sensory_box; TIGR00229 395495013268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013269 putative active site [active] 395495013270 heme pocket [chemical binding]; other site 395495013271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013272 PAS domain; Region: PAS_9; pfam13426 395495013273 putative active site [active] 395495013274 heme pocket [chemical binding]; other site 395495013275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013276 PAS domain; Region: PAS_9; pfam13426 395495013277 putative active site [active] 395495013278 heme pocket [chemical binding]; other site 395495013279 PAS fold; Region: PAS_4; pfam08448 395495013280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013281 putative active site [active] 395495013282 heme pocket [chemical binding]; other site 395495013283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495013284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013285 dimer interface [polypeptide binding]; other site 395495013286 phosphorylation site [posttranslational modification] 395495013287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013288 ATP binding site [chemical binding]; other site 395495013289 Mg2+ binding site [ion binding]; other site 395495013290 G-X-G motif; other site 395495013291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013292 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013293 active site 395495013294 phosphorylation site [posttranslational modification] 395495013295 intermolecular recognition site; other site 395495013296 dimerization interface [polypeptide binding]; other site 395495013297 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013299 active site 395495013300 phosphorylation site [posttranslational modification] 395495013301 intermolecular recognition site; other site 395495013302 dimerization interface [polypeptide binding]; other site 395495013303 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 395495013304 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 395495013305 TrkA-N domain; Region: TrkA_N; pfam02254 395495013306 TrkA-N domain; Region: TrkA_N; pfam02254 395495013307 TrkA-C domain; Region: TrkA_C; pfam02080 395495013308 Cation transport protein; Region: TrkH; cl17365 395495013309 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 395495013310 conserved hypothetical protein; Region: TIGR02270 395495013311 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 395495013312 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 395495013313 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 395495013314 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 395495013315 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 395495013316 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 395495013317 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 395495013318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495013319 TPR motif; other site 395495013320 TPR repeat; Region: TPR_11; pfam13414 395495013321 binding surface 395495013322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495013323 binding surface 395495013324 TPR repeat; Region: TPR_11; pfam13414 395495013325 TPR motif; other site 395495013326 TPR repeat; Region: TPR_11; pfam13414 395495013327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495013328 binding surface 395495013329 TPR motif; other site 395495013330 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 395495013331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495013332 S-adenosylmethionine binding site [chemical binding]; other site 395495013333 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 395495013334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495013335 Walker A motif; other site 395495013336 ATP binding site [chemical binding]; other site 395495013337 Walker B motif; other site 395495013338 arginine finger; other site 395495013339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495013340 Walker A motif; other site 395495013341 ATP binding site [chemical binding]; other site 395495013342 Walker B motif; other site 395495013343 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 395495013344 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 395495013345 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 395495013346 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 395495013347 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 395495013348 Protein of unknown function (DUF796); Region: DUF796; pfam05638 395495013349 Protein of unknown function (DUF796); Region: DUF796; pfam05638 395495013350 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 395495013351 Protein of unknown function (DUF877); Region: DUF877; pfam05943 395495013352 Protein of unknown function (DUF770); Region: DUF770; pfam05591 395495013353 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 395495013354 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 395495013355 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 395495013356 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 395495013357 CHAT domain; Region: CHAT; pfam12770 395495013358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495013359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013360 dimer interface [polypeptide binding]; other site 395495013361 phosphorylation site [posttranslational modification] 395495013362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013363 ATP binding site [chemical binding]; other site 395495013364 Mg2+ binding site [ion binding]; other site 395495013365 G-X-G motif; other site 395495013366 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013368 active site 395495013369 phosphorylation site [posttranslational modification] 395495013370 intermolecular recognition site; other site 395495013371 dimerization interface [polypeptide binding]; other site 395495013372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 395495013373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013374 active site 395495013375 phosphorylation site [posttranslational modification] 395495013376 intermolecular recognition site; other site 395495013377 dimerization interface [polypeptide binding]; other site 395495013378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495013379 DNA binding residues [nucleotide binding] 395495013380 dimerization interface [polypeptide binding]; other site 395495013381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495013382 DNA binding residues [nucleotide binding] 395495013383 dimerization interface [polypeptide binding]; other site 395495013384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495013385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495013386 ligand binding site [chemical binding]; other site 395495013387 flexible hinge region; other site 395495013388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 395495013389 non-specific DNA interactions [nucleotide binding]; other site 395495013390 DNA binding site [nucleotide binding] 395495013391 sequence specific DNA binding site [nucleotide binding]; other site 395495013392 putative cAMP binding site [chemical binding]; other site 395495013393 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 395495013394 cyclase homology domain; Region: CHD; cd07302 395495013395 nucleotidyl binding site; other site 395495013396 metal binding site [ion binding]; metal-binding site 395495013397 dimer interface [polypeptide binding]; other site 395495013398 AAA ATPase domain; Region: AAA_16; pfam13191 395495013399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 395495013400 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 395495013401 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 395495013402 Peptidase family M48; Region: Peptidase_M48; pfam01435 395495013403 muropeptide transporter; Validated; Region: ampG; cl17669 395495013404 muropeptide transporter; Validated; Region: ampG; cl17669 395495013405 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 395495013406 thioredoxin 2; Provisional; Region: PRK10996 395495013407 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 395495013408 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 395495013409 catalytic residues [active] 395495013410 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 395495013411 active site 395495013412 dimer interface [polypeptide binding]; other site 395495013413 Predicted ATPase [General function prediction only]; Region: COG4637 395495013414 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 395495013415 adenylosuccinate lyase; Provisional; Region: PRK09285 395495013416 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 395495013417 tetramer interface [polypeptide binding]; other site 395495013418 active site 395495013419 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495013420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013421 putative active site [active] 395495013422 heme pocket [chemical binding]; other site 395495013423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013424 dimer interface [polypeptide binding]; other site 395495013425 phosphorylation site [posttranslational modification] 395495013426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013427 ATP binding site [chemical binding]; other site 395495013428 Mg2+ binding site [ion binding]; other site 395495013429 G-X-G motif; other site 395495013430 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495013431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013432 active site 395495013433 phosphorylation site [posttranslational modification] 395495013434 intermolecular recognition site; other site 395495013435 dimerization interface [polypeptide binding]; other site 395495013436 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013438 active site 395495013439 phosphorylation site [posttranslational modification] 395495013440 intermolecular recognition site; other site 395495013441 dimerization interface [polypeptide binding]; other site 395495013442 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 395495013443 putative binding surface; other site 395495013444 active site 395495013445 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 395495013446 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 395495013447 Cytochrome c; Region: Cytochrom_C; cl11414 395495013448 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495013449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013450 active site 395495013451 phosphorylation site [posttranslational modification] 395495013452 intermolecular recognition site; other site 395495013453 dimerization interface [polypeptide binding]; other site 395495013454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495013455 Walker A motif; other site 395495013456 ATP binding site [chemical binding]; other site 395495013457 Walker B motif; other site 395495013458 arginine finger; other site 395495013459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495013460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 395495013461 dimerization interface [polypeptide binding]; other site 395495013462 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 395495013463 Sel1-like repeats; Region: SEL1; smart00671 395495013464 Sel1-like repeats; Region: SEL1; smart00671 395495013465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 395495013466 TPR motif; other site 395495013467 TPR repeat; Region: TPR_11; pfam13414 395495013468 binding surface 395495013469 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 395495013470 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 395495013471 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 395495013472 NHL repeat; Region: NHL; pfam01436 395495013473 Uncharacterized conserved protein [Function unknown]; Region: COG3391 395495013474 NHL repeat; Region: NHL; pfam01436 395495013475 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 395495013476 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 395495013477 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 395495013478 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495013479 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 395495013480 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 395495013481 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 395495013482 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 395495013483 Uncharacterized conserved protein [Function unknown]; Region: COG3391 395495013484 NHL repeat; Region: NHL; pfam01436 395495013485 Cytochrome c; Region: Cytochrom_C; pfam00034 395495013486 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 395495013487 Cytochrome c; Region: Cytochrom_C; pfam00034 395495013488 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495013489 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 395495013490 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 395495013491 Bacterial transcriptional activator domain; Region: BTAD; smart01043 395495013492 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495013493 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495013494 ligand binding site [chemical binding]; other site 395495013495 flexible hinge region; other site 395495013496 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 395495013497 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 395495013498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 395495013499 catalytic residue [active] 395495013500 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 395495013501 putative transposase OrfB; Reviewed; Region: PHA02517 395495013502 Integrase core domain; Region: rve; pfam00665 395495013503 Integrase core domain; Region: rve_3; pfam13683 395495013504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 395495013505 Transposase; Region: HTH_Tnp_1; pfam01527 395495013506 Transposase; Region: HTH_Tnp_1; cl17663 395495013507 Homeodomain-like domain; Region: HTH_32; pfam13565 395495013508 Integrase core domain; Region: rve; pfam00665 395495013509 DDE domain; Region: DDE_Tnp_IS240; pfam13610 395495013510 Integrase core domain; Region: rve_3; pfam13683 395495013511 Integrase core domain; Region: rve; pfam00665 395495013512 DDE domain; Region: DDE_Tnp_IS240; pfam13610 395495013513 Integrase core domain; Region: rve_3; pfam13683 395495013514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495013515 Ligand Binding Site [chemical binding]; other site 395495013516 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 395495013517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 395495013518 Ligand Binding Site [chemical binding]; other site 395495013519 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 395495013520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495013521 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 395495013522 putative dimerization interface [polypeptide binding]; other site 395495013523 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 395495013524 hydrophobic ligand binding site; other site 395495013525 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 395495013526 putative hydrophobic ligand binding site [chemical binding]; other site 395495013527 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 395495013528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495013529 putative metal binding site [ion binding]; other site 395495013530 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 395495013531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 395495013532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495013533 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 395495013534 putative effector binding pocket; other site 395495013535 dimerization interface [polypeptide binding]; other site 395495013536 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 395495013537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 395495013538 motif II; other site 395495013539 malate synthase G; Provisional; Region: PRK02999 395495013540 active site 395495013541 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 395495013542 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 395495013543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395495013544 Virulence protein [General function prediction only]; Region: COG3943 395495013545 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 395495013546 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 395495013547 DNA methylase; Region: N6_N4_Mtase; pfam01555 395495013548 DNA methylase; Region: N6_N4_Mtase; pfam01555 395495013549 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 395495013550 active site residue [active] 395495013551 AIPR protein; Region: AIPR; pfam10592 395495013552 DEAD-like helicases superfamily; Region: DEXDc; smart00487 395495013553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495013554 ATP binding site [chemical binding]; other site 395495013555 putative Mg++ binding site [ion binding]; other site 395495013556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495013557 nucleotide binding region [chemical binding]; other site 395495013558 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 395495013559 ATP-binding site [chemical binding]; other site 395495013560 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 395495013561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 395495013562 putative substrate translocation pore; other site 395495013563 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013565 active site 395495013566 phosphorylation site [posttranslational modification] 395495013567 intermolecular recognition site; other site 395495013568 dimerization interface [polypeptide binding]; other site 395495013569 PAS domain S-box; Region: sensory_box; TIGR00229 395495013570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013571 putative active site [active] 395495013572 heme pocket [chemical binding]; other site 395495013573 GAF domain; Region: GAF_2; pfam13185 395495013574 GAF domain; Region: GAF_3; pfam13492 395495013575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 395495013576 metal binding site [ion binding]; metal-binding site 395495013577 active site 395495013578 I-site; other site 395495013579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 395495013580 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 395495013581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013582 active site 395495013583 phosphorylation site [posttranslational modification] 395495013584 intermolecular recognition site; other site 395495013585 dimerization interface [polypeptide binding]; other site 395495013586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013587 PAS domain; Region: PAS_9; pfam13426 395495013588 putative active site [active] 395495013589 heme pocket [chemical binding]; other site 395495013590 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495013591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013592 putative active site [active] 395495013593 heme pocket [chemical binding]; other site 395495013594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013595 dimer interface [polypeptide binding]; other site 395495013596 phosphorylation site [posttranslational modification] 395495013597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013598 ATP binding site [chemical binding]; other site 395495013599 Mg2+ binding site [ion binding]; other site 395495013600 G-X-G motif; other site 395495013601 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495013602 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495013603 ligand binding site [chemical binding]; other site 395495013604 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 395495013605 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 395495013606 NAD binding site [chemical binding]; other site 395495013607 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 395495013608 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 395495013609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 395495013610 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 395495013611 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 395495013612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495013613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 395495013614 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 395495013615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495013616 DNA-binding site [nucleotide binding]; DNA binding site 395495013617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 395495013618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495013619 homodimer interface [polypeptide binding]; other site 395495013620 catalytic residue [active] 395495013621 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 395495013622 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 395495013623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 395495013624 RNA binding surface [nucleotide binding]; other site 395495013625 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 395495013626 active site 395495013627 uracil binding [chemical binding]; other site 395495013628 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 395495013629 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 395495013630 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 395495013631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 395495013632 Protein of unknown function (DUF433); Region: DUF433; pfam04255 395495013633 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 395495013634 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 395495013635 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 395495013636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495013637 Walker A/P-loop; other site 395495013638 ATP binding site [chemical binding]; other site 395495013639 Q-loop/lid; other site 395495013640 ABC transporter signature motif; other site 395495013641 Walker B; other site 395495013642 D-loop; other site 395495013643 H-loop/switch region; other site 395495013644 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 395495013645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495013646 Walker A/P-loop; other site 395495013647 ATP binding site [chemical binding]; other site 395495013648 Q-loop/lid; other site 395495013649 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 395495013650 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 395495013651 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 395495013652 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 395495013653 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 395495013654 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 395495013655 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 395495013656 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 395495013657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495013658 S-adenosylmethionine binding site [chemical binding]; other site 395495013659 LysE type translocator; Region: LysE; cl00565 395495013660 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 395495013661 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495013662 P-loop; other site 395495013663 Magnesium ion binding site [ion binding]; other site 395495013664 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 395495013665 Magnesium ion binding site [ion binding]; other site 395495013666 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 395495013667 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 395495013668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 395495013669 DNA binding residues [nucleotide binding] 395495013670 putative dimer interface [polypeptide binding]; other site 395495013671 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 395495013672 CoenzymeA binding site [chemical binding]; other site 395495013673 subunit interaction site [polypeptide binding]; other site 395495013674 PHB binding site; other site 395495013675 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 395495013676 active site clefts [active] 395495013677 zinc binding site [ion binding]; other site 395495013678 dimer interface [polypeptide binding]; other site 395495013679 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 395495013680 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 395495013681 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 395495013682 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 395495013683 dimer interface [polypeptide binding]; other site 395495013684 active site 395495013685 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 395495013686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 395495013687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 395495013688 active site 395495013689 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 395495013690 Mrr N-terminal domain; Region: Mrr_N; pfam14338 395495013691 Restriction endonuclease; Region: Mrr_cat; pfam04471 395495013692 PAS domain S-box; Region: sensory_box; TIGR00229 395495013693 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013694 putative active site [active] 395495013695 heme pocket [chemical binding]; other site 395495013696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495013697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013698 dimer interface [polypeptide binding]; other site 395495013699 phosphorylation site [posttranslational modification] 395495013700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013701 ATP binding site [chemical binding]; other site 395495013702 Mg2+ binding site [ion binding]; other site 395495013703 G-X-G motif; other site 395495013704 Response regulator receiver domain; Region: Response_reg; pfam00072 395495013705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013706 active site 395495013707 phosphorylation site [posttranslational modification] 395495013708 intermolecular recognition site; other site 395495013709 dimerization interface [polypeptide binding]; other site 395495013710 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 395495013711 PAS fold; Region: PAS_4; pfam08448 395495013712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 395495013713 putative active site [active] 395495013714 heme pocket [chemical binding]; other site 395495013715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 395495013716 PAS domain; Region: PAS; smart00091 395495013717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013718 dimer interface [polypeptide binding]; other site 395495013719 phosphorylation site [posttranslational modification] 395495013720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013721 ATP binding site [chemical binding]; other site 395495013722 Mg2+ binding site [ion binding]; other site 395495013723 G-X-G motif; other site 395495013724 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 395495013725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 395495013726 substrate binding pocket [chemical binding]; other site 395495013727 membrane-bound complex binding site; other site 395495013728 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 395495013729 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 395495013730 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 395495013731 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395495013732 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 395495013733 putative N-terminal domain interface [polypeptide binding]; other site 395495013734 putative dimer interface [polypeptide binding]; other site 395495013735 putative substrate binding pocket (H-site) [chemical binding]; other site 395495013736 Cupin domain; Region: Cupin_2; cl17218 395495013737 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 395495013738 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 395495013739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 395495013740 active site 395495013741 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495013742 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 395495013743 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 395495013744 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 395495013745 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 395495013746 Predicted membrane protein [Function unknown]; Region: COG3235 395495013747 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 395495013748 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 395495013749 putative catalytic residue [active] 395495013750 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 395495013751 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 395495013752 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 395495013753 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 395495013754 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 395495013755 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 395495013756 Walker A/P-loop; other site 395495013757 ATP binding site [chemical binding]; other site 395495013758 Q-loop/lid; other site 395495013759 ABC transporter signature motif; other site 395495013760 Walker B; other site 395495013761 D-loop; other site 395495013762 H-loop/switch region; other site 395495013763 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 395495013764 OstA-like protein; Region: OstA; pfam03968 395495013765 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 395495013766 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 395495013767 catalytic residues [active] 395495013768 hinge region; other site 395495013769 alpha helical domain; other site 395495013770 Sporulation related domain; Region: SPOR; pfam05036 395495013771 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 395495013772 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 395495013773 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 395495013774 active site 395495013775 HIGH motif; other site 395495013776 KMSK motif region; other site 395495013777 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 395495013778 tRNA binding surface [nucleotide binding]; other site 395495013779 anticodon binding site; other site 395495013780 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 395495013781 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 395495013782 active site 395495013783 ATP binding site [chemical binding]; other site 395495013784 substrate binding site [chemical binding]; other site 395495013785 activation loop (A-loop); other site 395495013786 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 395495013787 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 395495013788 ligand binding site [chemical binding]; other site 395495013789 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 395495013790 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 395495013791 dimer interface [polypeptide binding]; other site 395495013792 [2Fe-2S] cluster binding site [ion binding]; other site 395495013793 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 395495013794 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 395495013795 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 395495013796 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 395495013797 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 395495013798 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 395495013799 homodimer interface [polypeptide binding]; other site 395495013800 substrate-cofactor binding pocket; other site 395495013801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495013802 catalytic residue [active] 395495013803 Protein of unknown function (DUF493); Region: DUF493; cl01102 395495013804 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 395495013805 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 395495013806 HDOD domain; Region: HDOD; pfam08668 395495013807 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 395495013808 putative hydrophobic ligand binding site [chemical binding]; other site 395495013809 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 395495013810 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 395495013811 CoA binding domain; Region: CoA_binding_2; pfam13380 395495013812 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 395495013813 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 395495013814 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 395495013815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 395495013816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 395495013817 Coenzyme A binding pocket [chemical binding]; other site 395495013818 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 395495013819 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 395495013820 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 395495013821 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 395495013822 isocitrate dehydrogenase; Validated; Region: PRK06451 395495013823 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 395495013824 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 395495013825 Predicted membrane protein [Function unknown]; Region: COG5393 395495013826 Domain of unknown function DUF59; Region: DUF59; cl00941 395495013827 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 395495013828 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 395495013829 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 395495013830 active site 395495013831 dimer interface [polypeptide binding]; other site 395495013832 effector binding site; other site 395495013833 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 395495013834 putative active site [active] 395495013835 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 395495013836 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 395495013837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 395495013838 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 395495013839 active site 395495013840 catalytic tetrad [active] 395495013841 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 395495013842 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 395495013843 GIY-YIG motif/motif A; other site 395495013844 active site 395495013845 catalytic site [active] 395495013846 putative DNA binding site [nucleotide binding]; other site 395495013847 metal binding site [ion binding]; metal-binding site 395495013848 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 395495013849 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 395495013850 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 395495013851 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 395495013852 HlyD family secretion protein; Region: HlyD_3; pfam13437 395495013853 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 395495013854 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395495013855 FtsX-like permease family; Region: FtsX; pfam02687 395495013856 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 395495013857 FtsX-like permease family; Region: FtsX; pfam02687 395495013858 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 395495013859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 395495013860 Walker A/P-loop; other site 395495013861 ATP binding site [chemical binding]; other site 395495013862 Q-loop/lid; other site 395495013863 ABC transporter signature motif; other site 395495013864 Walker B; other site 395495013865 D-loop; other site 395495013866 H-loop/switch region; other site 395495013867 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 395495013868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495013869 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 395495013870 dimerization interface [polypeptide binding]; other site 395495013871 substrate binding pocket [chemical binding]; other site 395495013872 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 395495013873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495013874 NAD(P) binding site [chemical binding]; other site 395495013875 active site 395495013876 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 395495013877 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 395495013878 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 395495013879 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 395495013880 DctM-like transporters; Region: DctM; pfam06808 395495013881 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 395495013882 TPP-binding site [chemical binding]; other site 395495013883 dimer interface [polypeptide binding]; other site 395495013884 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 395495013885 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 395495013886 PYR/PP interface [polypeptide binding]; other site 395495013887 dimer interface [polypeptide binding]; other site 395495013888 TPP binding site [chemical binding]; other site 395495013889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 395495013890 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 395495013891 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 395495013892 homodimer interface [polypeptide binding]; other site 395495013893 substrate-cofactor binding pocket; other site 395495013894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 395495013895 catalytic residue [active] 395495013896 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 395495013897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 395495013898 catalytic core [active] 395495013899 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 395495013900 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 395495013901 putative ligand binding site [chemical binding]; other site 395495013902 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 395495013903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495013904 dimer interface [polypeptide binding]; other site 395495013905 phosphorylation site [posttranslational modification] 395495013906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495013907 ATP binding site [chemical binding]; other site 395495013908 G-X-G motif; other site 395495013909 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 395495013910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495013911 active site 395495013912 phosphorylation site [posttranslational modification] 395495013913 intermolecular recognition site; other site 395495013914 dimerization interface [polypeptide binding]; other site 395495013915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 395495013916 DNA binding residues [nucleotide binding] 395495013917 dimerization interface [polypeptide binding]; other site 395495013918 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 395495013919 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 395495013920 PhnA protein; Region: PhnA; pfam03831 395495013921 Uncharacterized conserved protein [Function unknown]; Region: COG3148 395495013922 DNA methylase; Region: N6_N4_Mtase; pfam01555 395495013923 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 395495013924 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 395495013925 PLD-like domain; Region: PLDc_2; pfam13091 395495013926 putative homodimer interface [polypeptide binding]; other site 395495013927 putative active site [active] 395495013928 catalytic site [active] 395495013929 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 395495013930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 395495013931 putative Mg++ binding site [ion binding]; other site 395495013932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495013933 nucleotide binding region [chemical binding]; other site 395495013934 ATP-binding site [chemical binding]; other site 395495013935 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 395495013936 hypothetical protein; Provisional; Region: PRK10040 395495013937 Predicted membrane protein [Function unknown]; Region: COG3671 395495013938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 395495013939 non-specific DNA binding site [nucleotide binding]; other site 395495013940 salt bridge; other site 395495013941 sequence-specific DNA binding site [nucleotide binding]; other site 395495013942 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 395495013943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 395495013944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 395495013945 dimerization interface [polypeptide binding]; other site 395495013946 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 395495013947 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 395495013948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 395495013949 Bacterial transcriptional regulator; Region: IclR; pfam01614 395495013950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 395495013951 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 395495013952 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495013953 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 395495013954 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 395495013955 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 395495013956 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 395495013957 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 395495013958 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 395495013959 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 395495013960 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 395495013961 XdhC Rossmann domain; Region: XdhC_C; pfam13478 395495013962 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 395495013963 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 395495013964 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495013965 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 395495013966 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 395495013967 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495013968 catalytic loop [active] 395495013969 iron binding site [ion binding]; other site 395495013970 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 395495013971 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 395495013972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 395495013973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 395495013974 Phasin protein; Region: Phasin_2; pfam09361 395495013975 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 395495013976 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 395495013977 active site 395495013978 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495013979 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495013980 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495013981 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 395495013982 Zn2+ binding site [ion binding]; other site 395495013983 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 395495013984 active site 395495013985 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 395495013986 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 395495013987 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 395495013988 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 395495013989 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 395495013990 dimerization interface [polypeptide binding]; other site 395495013991 active site 395495013992 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 395495013993 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 395495013994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495013995 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 395495013996 dimer interface [polypeptide binding]; other site 395495013997 conserved gate region; other site 395495013998 putative PBP binding loops; other site 395495013999 ABC-ATPase subunit interface; other site 395495014000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495014001 dimer interface [polypeptide binding]; other site 395495014002 conserved gate region; other site 395495014003 putative PBP binding loops; other site 395495014004 ABC-ATPase subunit interface; other site 395495014005 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 395495014006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 395495014007 Walker A/P-loop; other site 395495014008 ATP binding site [chemical binding]; other site 395495014009 Q-loop/lid; other site 395495014010 ABC transporter signature motif; other site 395495014011 Walker B; other site 395495014012 D-loop; other site 395495014013 H-loop/switch region; other site 395495014014 TOBE domain; Region: TOBE_2; pfam08402 395495014015 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 395495014016 beta-galactosidase; Region: BGL; TIGR03356 395495014017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 395495014018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 395495014019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495014020 dimer interface [polypeptide binding]; other site 395495014021 conserved gate region; other site 395495014022 ABC-ATPase subunit interface; other site 395495014023 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 395495014024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 395495014025 dimer interface [polypeptide binding]; other site 395495014026 conserved gate region; other site 395495014027 putative PBP binding loops; other site 395495014028 ABC-ATPase subunit interface; other site 395495014029 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 395495014030 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 395495014031 Walker A/P-loop; other site 395495014032 ATP binding site [chemical binding]; other site 395495014033 Q-loop/lid; other site 395495014034 ABC transporter signature motif; other site 395495014035 Walker B; other site 395495014036 D-loop; other site 395495014037 H-loop/switch region; other site 395495014038 TOBE domain; Region: TOBE_2; pfam08402 395495014039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 395495014040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 395495014041 DNA binding site [nucleotide binding] 395495014042 domain linker motif; other site 395495014043 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 395495014044 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495014045 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495014046 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 395495014047 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 395495014048 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 395495014049 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 395495014050 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 395495014051 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 395495014052 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 395495014053 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 395495014054 Domain of unknown function DUF11; Region: DUF11; cl17728 395495014055 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 395495014056 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 395495014057 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 395495014058 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 395495014059 dimer interface [polypeptide binding]; other site 395495014060 putative CheW interface [polypeptide binding]; other site 395495014061 RES domain; Region: RES; smart00953 395495014062 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 395495014063 oligomeric interface; other site 395495014064 putative active site [active] 395495014065 homodimer interface [polypeptide binding]; other site 395495014066 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 395495014067 Lysine efflux permease [General function prediction only]; Region: COG1279 395495014068 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 395495014069 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 395495014070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 395495014071 active site 395495014072 phosphorylation site [posttranslational modification] 395495014073 intermolecular recognition site; other site 395495014074 dimerization interface [polypeptide binding]; other site 395495014075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 395495014076 Walker A motif; other site 395495014077 ATP binding site [chemical binding]; other site 395495014078 Walker B motif; other site 395495014079 arginine finger; other site 395495014080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 395495014081 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 395495014082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495014083 dimer interface [polypeptide binding]; other site 395495014084 phosphorylation site [posttranslational modification] 395495014085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495014086 ATP binding site [chemical binding]; other site 395495014087 Mg2+ binding site [ion binding]; other site 395495014088 G-X-G motif; other site 395495014089 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 395495014090 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 395495014091 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495014092 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 395495014093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495014094 DNA-binding site [nucleotide binding]; DNA binding site 395495014095 FCD domain; Region: FCD; pfam07729 395495014096 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 395495014097 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 395495014098 Transcriptional regulators [Transcription]; Region: GntR; COG1802 395495014099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 395495014100 DNA-binding site [nucleotide binding]; DNA binding site 395495014101 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 395495014102 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 395495014103 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495014104 catalytic loop [active] 395495014105 iron binding site [ion binding]; other site 395495014106 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 395495014107 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495014108 catalytic loop [active] 395495014109 iron binding site [ion binding]; other site 395495014110 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 395495014111 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 395495014112 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 395495014113 NAD(P) binding site [chemical binding]; other site 395495014114 catalytic residues [active] 395495014115 Domain of unknown function (DUF336); Region: DUF336; pfam03928 395495014116 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 395495014117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 395495014118 catalytic loop [active] 395495014119 iron binding site [ion binding]; other site 395495014120 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 395495014121 FAD binding pocket [chemical binding]; other site 395495014122 FAD binding motif [chemical binding]; other site 395495014123 phosphate binding motif [ion binding]; other site 395495014124 beta-alpha-beta structure motif; other site 395495014125 NAD binding pocket [chemical binding]; other site 395495014126 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 395495014127 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 395495014128 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 395495014129 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 395495014130 putative C-terminal domain interface [polypeptide binding]; other site 395495014131 putative GSH binding site (G-site) [chemical binding]; other site 395495014132 putative dimer interface [polypeptide binding]; other site 395495014133 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 395495014134 N-terminal domain interface [polypeptide binding]; other site 395495014135 dimer interface [polypeptide binding]; other site 395495014136 substrate binding pocket (H-site) [chemical binding]; other site 395495014137 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 395495014138 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 395495014139 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 395495014140 PBP superfamily domain; Region: PBP_like_2; cl17296 395495014141 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 395495014142 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 395495014143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 395495014144 ligand binding site [chemical binding]; other site 395495014145 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 395495014146 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 395495014147 catalytic triad [active] 395495014148 YCII-related domain; Region: YCII; cl00999 395495014149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 395495014150 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 395495014151 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 395495014152 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 395495014153 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 395495014154 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 395495014155 ATP binding site [chemical binding]; other site 395495014156 Mg++ binding site [ion binding]; other site 395495014157 motif III; other site 395495014158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 395495014159 nucleotide binding region [chemical binding]; other site 395495014160 ATP-binding site [chemical binding]; other site 395495014161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 395495014162 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 395495014163 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 395495014164 SelR domain; Region: SelR; pfam01641 395495014165 Divergent AAA domain; Region: AAA_4; pfam04326 395495014166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 395495014167 C factor cell-cell signaling protein; Provisional; Region: PRK09009 395495014168 NAD(P) binding site [chemical binding]; other site 395495014169 active site 395495014170 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 395495014171 B12 binding site [chemical binding]; other site 395495014172 Radical SAM superfamily; Region: Radical_SAM; pfam04055 395495014173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 395495014174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 395495014175 dimer interface [polypeptide binding]; other site 395495014176 phosphorylation site [posttranslational modification] 395495014177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 395495014178 ATP binding site [chemical binding]; other site 395495014179 Mg2+ binding site [ion binding]; other site 395495014180 G-X-G motif; other site 395495014181 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 395495014182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 395495014183 MOSC domain; Region: MOSC; pfam03473 395495014184 AAA domain; Region: AAA_11; pfam13086 395495014185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 395495014186 ATP binding site [chemical binding]; other site 395495014187 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 395495014188 AAA domain; Region: AAA_12; pfam13087 395495014189 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 395495014190 Serine hydrolase (FSH1); Region: FSH1; pfam03959 395495014191 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 395495014192 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 395495014193 putative heme binding pocket [chemical binding]; other site 395495014194 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 395495014195 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 395495014196 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 395495014197 FMN binding site [chemical binding]; other site 395495014198 substrate binding site [chemical binding]; other site 395495014199 putative catalytic residue [active] 395495014200 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 395495014201 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 395495014202 Methyltransferase domain; Region: Methyltransf_31; pfam13847 395495014203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 395495014204 S-adenosylmethionine binding site [chemical binding]; other site 395495014205 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 395495014206 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 395495014207 trmE is a tRNA modification GTPase; Region: trmE; cd04164 395495014208 G1 box; other site 395495014209 GTP/Mg2+ binding site [chemical binding]; other site 395495014210 Switch I region; other site 395495014211 G2 box; other site 395495014212 Switch II region; other site 395495014213 G3 box; other site 395495014214 G4 box; other site 395495014215 G5 box; other site 395495014216 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 395495014217 membrane protein insertase; Provisional; Region: PRK01318 395495014218 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 395495014219 Haemolytic domain; Region: Haemolytic; cl00506 395495014220 Ribonuclease P; Region: Ribonuclease_P; cl00457 395495014221 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399