-- dump date 20140619_131558 -- class Genbank::misc_feature -- table misc_feature_note -- id note 523794000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 523794000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794000003 Walker A motif; other site 523794000004 ATP binding site [chemical binding]; other site 523794000005 Walker B motif; other site 523794000006 arginine finger; other site 523794000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 523794000008 DnaA box-binding interface [nucleotide binding]; other site 523794000009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794000010 RNA binding surface [nucleotide binding]; other site 523794000011 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794000012 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 523794000013 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 523794000014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000015 Walker A/P-loop; other site 523794000016 ATP binding site [chemical binding]; other site 523794000017 Q-loop/lid; other site 523794000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000019 ABC transporter signature motif; other site 523794000020 Walker B; other site 523794000021 D-loop; other site 523794000022 H-loop/switch region; other site 523794000023 Protein of unknown function (DUF721); Region: DUF721; pfam05258 523794000024 Spherulation-specific family 4; Region: Spherulin4; pfam12138 523794000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794000026 binding surface 523794000027 TPR motif; other site 523794000028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794000029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794000030 binding surface 523794000031 TPR motif; other site 523794000032 TPR repeat; Region: TPR_11; pfam13414 523794000033 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 523794000034 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 523794000035 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 523794000036 Predicted membrane protein [Function unknown]; Region: COG2510 523794000037 Predicted membrane protein [Function unknown]; Region: COG2510 523794000038 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 523794000039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523794000040 ABC-ATPase subunit interface; other site 523794000041 dimer interface [polypeptide binding]; other site 523794000042 putative PBP binding regions; other site 523794000043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523794000044 ABC-ATPase subunit interface; other site 523794000045 dimer interface [polypeptide binding]; other site 523794000046 putative PBP binding regions; other site 523794000047 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 523794000048 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 523794000049 Walker A/P-loop; other site 523794000050 ATP binding site [chemical binding]; other site 523794000051 Q-loop/lid; other site 523794000052 ABC transporter signature motif; other site 523794000053 Walker B; other site 523794000054 D-loop; other site 523794000055 H-loop/switch region; other site 523794000056 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 523794000057 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 523794000058 putative ligand binding residues [chemical binding]; other site 523794000059 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794000060 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 523794000061 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523794000062 active site 523794000063 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523794000064 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 523794000065 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794000066 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794000067 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 523794000068 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 523794000069 active site 523794000070 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 523794000071 active site 523794000072 N-terminal domain interface [polypeptide binding]; other site 523794000073 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523794000074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000075 dimer interface [polypeptide binding]; other site 523794000076 conserved gate region; other site 523794000077 putative PBP binding loops; other site 523794000078 ABC-ATPase subunit interface; other site 523794000079 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 523794000080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000081 dimer interface [polypeptide binding]; other site 523794000082 conserved gate region; other site 523794000083 putative PBP binding loops; other site 523794000084 ABC-ATPase subunit interface; other site 523794000085 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523794000086 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 523794000087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794000088 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 523794000089 Walker A/P-loop; other site 523794000090 ATP binding site [chemical binding]; other site 523794000091 Q-loop/lid; other site 523794000092 ABC transporter signature motif; other site 523794000093 Walker B; other site 523794000094 D-loop; other site 523794000095 H-loop/switch region; other site 523794000096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523794000097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794000098 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523794000099 Walker A/P-loop; other site 523794000100 ATP binding site [chemical binding]; other site 523794000101 Q-loop/lid; other site 523794000102 ABC transporter signature motif; other site 523794000103 Walker B; other site 523794000104 D-loop; other site 523794000105 H-loop/switch region; other site 523794000106 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 523794000107 active site 523794000108 SAM binding site [chemical binding]; other site 523794000109 homodimer interface [polypeptide binding]; other site 523794000110 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 523794000111 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 523794000112 active site 523794000113 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 523794000114 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 523794000115 domain interfaces; other site 523794000116 active site 523794000117 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 523794000118 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 523794000119 tRNA; other site 523794000120 putative tRNA binding site [nucleotide binding]; other site 523794000121 putative NADP binding site [chemical binding]; other site 523794000122 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 523794000123 active site 523794000124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000125 AAA domain; Region: AAA_21; pfam13304 523794000126 Walker A/P-loop; other site 523794000127 ATP binding site [chemical binding]; other site 523794000128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000129 ABC transporter signature motif; other site 523794000130 Walker B; other site 523794000131 D-loop; other site 523794000132 H-loop/switch region; other site 523794000133 Transposase; Region: HTH_Tnp_IS630; pfam01710 523794000134 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523794000135 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523794000136 peptide binding site [polypeptide binding]; other site 523794000137 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 523794000138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794000140 homodimer interface [polypeptide binding]; other site 523794000141 catalytic residue [active] 523794000142 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 523794000143 cobyric acid synthase; Provisional; Region: PRK00784 523794000144 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523794000145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523794000146 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 523794000147 catalytic triad [active] 523794000148 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 523794000149 Zonular occludens toxin (Zot); Region: Zot; cl17485 523794000150 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 523794000151 ORMDL family; Region: ORMDL; cl02117 523794000152 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 523794000153 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 523794000154 DNA binding residues [nucleotide binding] 523794000155 putative dimer interface [polypeptide binding]; other site 523794000156 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 523794000157 classical (c) SDRs; Region: SDR_c; cd05233 523794000158 NAD(P) binding site [chemical binding]; other site 523794000159 active site 523794000160 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794000162 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794000163 Probable transposase; Region: OrfB_IS605; pfam01385 523794000164 cobalamin synthase; Reviewed; Region: cobS; PRK00235 523794000165 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 523794000166 dimer interface [polypeptide binding]; other site 523794000167 catalytic triad [active] 523794000168 peroxidatic and resolving cysteines [active] 523794000169 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 523794000170 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 523794000171 substrate binding site [chemical binding]; other site 523794000172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523794000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000174 dimer interface [polypeptide binding]; other site 523794000175 conserved gate region; other site 523794000176 putative PBP binding loops; other site 523794000177 ABC-ATPase subunit interface; other site 523794000178 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 523794000179 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 523794000180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000181 dimer interface [polypeptide binding]; other site 523794000182 conserved gate region; other site 523794000183 putative PBP binding loops; other site 523794000184 ABC-ATPase subunit interface; other site 523794000185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794000186 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 523794000187 Walker A/P-loop; other site 523794000188 ATP binding site [chemical binding]; other site 523794000189 Q-loop/lid; other site 523794000190 ABC transporter signature motif; other site 523794000191 Walker B; other site 523794000192 D-loop; other site 523794000193 H-loop/switch region; other site 523794000194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523794000195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794000196 Walker A/P-loop; other site 523794000197 ATP binding site [chemical binding]; other site 523794000198 Q-loop/lid; other site 523794000199 ABC transporter signature motif; other site 523794000200 Walker B; other site 523794000201 D-loop; other site 523794000202 H-loop/switch region; other site 523794000203 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 523794000204 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 523794000205 ethanolamine utilization protein EutH; Provisional; Region: PRK15086 523794000206 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 523794000207 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 523794000208 putative hexamer interface [polypeptide binding]; other site 523794000209 putative hexagonal pore; other site 523794000210 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 523794000211 putative hexamer interface [polypeptide binding]; other site 523794000212 putative hexagonal pore; other site 523794000213 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 523794000214 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 523794000215 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 523794000216 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 523794000217 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 523794000218 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 523794000219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 523794000220 Histidine kinase; Region: HisKA_2; pfam07568 523794000221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794000222 ATP binding site [chemical binding]; other site 523794000223 Mg2+ binding site [ion binding]; other site 523794000224 G-X-G motif; other site 523794000225 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 523794000226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794000227 active site 523794000228 phosphorylation site [posttranslational modification] 523794000229 intermolecular recognition site; other site 523794000230 dimerization interface [polypeptide binding]; other site 523794000231 ANTAR domain; Region: ANTAR; pfam03861 523794000232 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 523794000233 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 523794000234 active site 523794000235 NAD binding site [chemical binding]; other site 523794000236 metal binding site [ion binding]; metal-binding site 523794000237 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 523794000238 Hexamer/Pentamer interface [polypeptide binding]; other site 523794000239 central pore; other site 523794000240 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 523794000241 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 523794000242 Propanediol utilisation protein PduL; Region: PduL; pfam06130 523794000243 Propanediol utilisation protein PduL; Region: PduL; pfam06130 523794000244 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 523794000245 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 523794000246 putative catalytic cysteine [active] 523794000247 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 523794000248 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 523794000249 Hexamer interface [polypeptide binding]; other site 523794000250 Putative hexagonal pore residue; other site 523794000251 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 523794000252 Hexamer interface [polypeptide binding]; other site 523794000253 Hexagonal pore residue; other site 523794000254 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 523794000255 G2 box; other site 523794000256 Switch I region; other site 523794000257 G3 box; other site 523794000258 Switch II region; other site 523794000259 GTP/Mg2+ binding site [chemical binding]; other site 523794000260 G4 box; other site 523794000261 G5 box; other site 523794000262 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 523794000263 putative hexamer interface [polypeptide binding]; other site 523794000264 putative hexagonal pore; other site 523794000265 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 523794000266 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 523794000267 Hexamer interface [polypeptide binding]; other site 523794000268 Putative hexagonal pore residue; other site 523794000269 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 523794000270 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 523794000271 Hexamer interface [polypeptide binding]; other site 523794000272 Putative hexagonal pore residue; other site 523794000273 RelB antitoxin; Region: RelB; cl01171 523794000274 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 523794000275 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794000276 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 523794000277 Predicted transcriptional regulators [Transcription]; Region: COG1733 523794000278 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 523794000279 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 523794000280 cobalt transport protein CbiM; Validated; Region: PRK08319 523794000281 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 523794000282 cobalt transport protein CbiN; Provisional; Region: PRK02898 523794000283 Cobalt transport protein; Region: CbiQ; cl00463 523794000284 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523794000285 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523794000286 Walker A/P-loop; other site 523794000287 ATP binding site [chemical binding]; other site 523794000288 Q-loop/lid; other site 523794000289 ABC transporter signature motif; other site 523794000290 Walker B; other site 523794000291 D-loop; other site 523794000292 H-loop/switch region; other site 523794000293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523794000294 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 523794000295 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 523794000296 catalytic triad [active] 523794000297 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 523794000298 Precorrin-8X methylmutase; Region: CbiC; pfam02570 523794000299 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 523794000300 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 523794000301 AAA domain; Region: AAA_14; pfam13173 523794000302 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 523794000303 active site 523794000304 SAM binding site [chemical binding]; other site 523794000305 homodimer interface [polypeptide binding]; other site 523794000306 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 523794000307 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 523794000308 Predicted transcriptional regulators [Transcription]; Region: COG1733 523794000309 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 523794000310 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 523794000311 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 523794000312 active site 523794000313 SAM binding site [chemical binding]; other site 523794000314 homodimer interface [polypeptide binding]; other site 523794000315 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 523794000316 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 523794000317 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 523794000318 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 523794000319 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 523794000320 active site 523794000321 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 523794000322 active site 523794000323 N-terminal domain interface [polypeptide binding]; other site 523794000324 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 523794000325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794000326 S-adenosylmethionine binding site [chemical binding]; other site 523794000327 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 523794000328 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 523794000329 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 523794000330 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 523794000331 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 523794000332 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 523794000333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794000334 S-adenosylmethionine binding site [chemical binding]; other site 523794000335 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 523794000336 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 523794000337 active site 523794000338 Zn binding site [ion binding]; other site 523794000339 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 523794000340 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 523794000341 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 523794000342 dimer interface [polypeptide binding]; other site 523794000343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794000344 catalytic residue [active] 523794000345 serine O-acetyltransferase; Region: cysE; TIGR01172 523794000346 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 523794000347 trimer interface [polypeptide binding]; other site 523794000348 active site 523794000349 substrate binding site [chemical binding]; other site 523794000350 CoA binding site [chemical binding]; other site 523794000351 flavodoxin FldA; Validated; Region: PRK09267 523794000352 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 523794000353 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 523794000354 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 523794000355 DAK2 domain; Region: Dak2; pfam02734 523794000356 EDD domain protein, DegV family; Region: DegV; TIGR00762 523794000357 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 523794000358 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 523794000359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794000360 active site 523794000361 motif I; other site 523794000362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523794000363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523794000364 protein binding site [polypeptide binding]; other site 523794000365 YCII-related domain; Region: YCII; cl00999 523794000366 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 523794000367 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 523794000368 acyl-activating enzyme (AAE) consensus motif; other site 523794000369 putative AMP binding site [chemical binding]; other site 523794000370 putative active site [active] 523794000371 putative CoA binding site [chemical binding]; other site 523794000372 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 523794000373 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523794000374 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523794000375 putative acyl-acceptor binding pocket; other site 523794000376 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 523794000377 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 523794000378 dimer interface [polypeptide binding]; other site 523794000379 putative anticodon binding site; other site 523794000380 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 523794000381 motif 1; other site 523794000382 active site 523794000383 motif 2; other site 523794000384 motif 3; other site 523794000385 Uncharacterized conserved protein [Function unknown]; Region: COG1576 523794000386 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 523794000387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794000388 ATP binding site [chemical binding]; other site 523794000389 Mg2+ binding site [ion binding]; other site 523794000390 G-X-G motif; other site 523794000391 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 523794000392 ATP binding site [chemical binding]; other site 523794000393 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 523794000394 diphosphomevalonate decarboxylase; Region: PLN02407 523794000395 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 523794000396 mevalonate kinase; Region: mevalon_kin; TIGR00549 523794000397 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523794000398 signal recognition particle protein; Provisional; Region: PRK10867 523794000399 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 523794000400 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523794000401 P loop; other site 523794000402 GTP binding site [chemical binding]; other site 523794000403 Signal peptide binding domain; Region: SRP_SPB; pfam02978 523794000404 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 523794000405 putative active site [active] 523794000406 catalytic site [active] 523794000407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794000408 ATP binding site [chemical binding]; other site 523794000409 putative Mg++ binding site [ion binding]; other site 523794000410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794000411 nucleotide binding region [chemical binding]; other site 523794000412 ATP-binding site [chemical binding]; other site 523794000413 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 523794000414 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 523794000415 DNA methylase; Region: N6_N4_Mtase; pfam01555 523794000416 DNA methylase; Region: N6_N4_Mtase; cl17433 523794000417 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 523794000418 RelB antitoxin; Region: RelB; cl01171 523794000419 Restriction endonuclease [Defense mechanisms]; Region: COG3587 523794000420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794000421 ATP binding site [chemical binding]; other site 523794000422 putative Mg++ binding site [ion binding]; other site 523794000423 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 523794000424 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 523794000425 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 523794000426 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 523794000427 active site 523794000428 dimer interface [polypeptide binding]; other site 523794000429 motif 1; other site 523794000430 motif 2; other site 523794000431 motif 3; other site 523794000432 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 523794000433 anticodon binding site; other site 523794000434 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 523794000435 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 523794000436 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 523794000437 metal binding site [ion binding]; metal-binding site 523794000438 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 523794000439 Predicted membrane protein [Function unknown]; Region: COG3619 523794000440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794000441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794000442 active site 523794000443 phosphorylation site [posttranslational modification] 523794000444 intermolecular recognition site; other site 523794000445 dimerization interface [polypeptide binding]; other site 523794000446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794000447 DNA binding site [nucleotide binding] 523794000448 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 523794000449 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 523794000450 ssDNA binding site; other site 523794000451 generic binding surface II; other site 523794000452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794000453 ATP binding site [chemical binding]; other site 523794000454 putative Mg++ binding site [ion binding]; other site 523794000455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794000456 nucleotide binding region [chemical binding]; other site 523794000457 ATP-binding site [chemical binding]; other site 523794000458 EamA-like transporter family; Region: EamA; pfam00892 523794000459 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 523794000460 EamA-like transporter family; Region: EamA; pfam00892 523794000461 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 523794000462 active site 523794000463 catalytic residues [active] 523794000464 metal binding site [ion binding]; metal-binding site 523794000465 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 523794000466 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 523794000467 putative active site [active] 523794000468 substrate binding site [chemical binding]; other site 523794000469 putative cosubstrate binding site; other site 523794000470 catalytic site [active] 523794000471 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 523794000472 substrate binding site [chemical binding]; other site 523794000473 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 523794000474 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 523794000475 CoA binding domain; Region: CoA_binding; smart00881 523794000476 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 523794000477 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 523794000478 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 523794000479 homodimer interface [polypeptide binding]; other site 523794000480 NADP binding site [chemical binding]; other site 523794000481 substrate binding site [chemical binding]; other site 523794000482 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 523794000483 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523794000484 carboxyltransferase (CT) interaction site; other site 523794000485 biotinylation site [posttranslational modification]; other site 523794000486 Domain of unknown function DUF21; Region: DUF21; pfam01595 523794000487 FOG: CBS domain [General function prediction only]; Region: COG0517 523794000488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523794000489 Transporter associated domain; Region: CorC_HlyC; smart01091 523794000490 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 523794000491 nudix motif; other site 523794000492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794000493 active site 523794000494 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 523794000495 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 523794000496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794000497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794000498 binding surface 523794000499 TPR motif; other site 523794000500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794000501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 523794000502 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 523794000503 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 523794000504 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 523794000505 putative active site [active] 523794000506 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 523794000507 beta-galactosidase; Region: BGL; TIGR03356 523794000508 TraX protein; Region: TraX; pfam05857 523794000509 Predicted membrane protein [Function unknown]; Region: COG2364 523794000510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 523794000511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523794000512 active site 523794000513 metal binding site [ion binding]; metal-binding site 523794000514 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 523794000515 Predicted membrane protein [Function unknown]; Region: COG1289 523794000516 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 523794000517 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 523794000518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000519 Walker A/P-loop; other site 523794000520 ATP binding site [chemical binding]; other site 523794000521 Q-loop/lid; other site 523794000522 ABC transporter signature motif; other site 523794000523 Walker B; other site 523794000524 D-loop; other site 523794000525 H-loop/switch region; other site 523794000526 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 523794000527 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523794000528 Transposase; Region: HTH_Tnp_IS630; pfam01710 523794000529 DDE superfamily endonuclease; Region: DDE_3; pfam13358 523794000530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 523794000531 CAAX protease self-immunity; Region: Abi; pfam02517 523794000532 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 523794000533 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523794000534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794000535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794000536 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 523794000537 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 523794000538 Mg++ binding site [ion binding]; other site 523794000539 putative catalytic motif [active] 523794000540 putative substrate binding site [chemical binding]; other site 523794000541 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 523794000542 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794000543 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794000544 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 523794000545 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 523794000546 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 523794000547 active site 523794000548 homodimer interface [polypeptide binding]; other site 523794000549 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 523794000550 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523794000551 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794000552 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794000553 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 523794000554 FAD binding domain; Region: FAD_binding_4; pfam01565 523794000555 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 523794000556 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 523794000557 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 523794000558 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 523794000559 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 523794000560 nucleotide binding site [chemical binding]; other site 523794000561 SulA interaction site; other site 523794000562 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 523794000563 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 523794000564 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 523794000565 dimer interface [polypeptide binding]; other site 523794000566 ssDNA binding site [nucleotide binding]; other site 523794000567 tetramer (dimer of dimers) interface [polypeptide binding]; other site 523794000568 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 523794000569 Transposase IS200 like; Region: Y1_Tnp; pfam01797 523794000570 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794000571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794000572 Probable transposase; Region: OrfB_IS605; pfam01385 523794000573 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 523794000574 camphor resistance protein CrcB; Provisional; Region: PRK14195 523794000575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523794000576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523794000577 putative substrate translocation pore; other site 523794000578 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 523794000579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794000580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794000581 ABC transporter; Region: ABC_tran_2; pfam12848 523794000582 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794000583 TPR repeat; Region: TPR_11; pfam13414 523794000584 Fic/DOC family; Region: Fic; cl00960 523794000585 DKNYY family; Region: DKNYY; pfam13644 523794000586 DKNYY family; Region: DKNYY; pfam13644 523794000587 DKNYY family; Region: DKNYY; pfam13644 523794000588 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794000589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794000590 binding surface 523794000591 TPR motif; other site 523794000592 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 523794000593 active site 523794000594 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 523794000595 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 523794000596 Domain of unknown function (DUF333); Region: DUF333; pfam03891 523794000597 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 523794000598 Domain of unknown function (DUF333); Region: DUF333; pfam03891 523794000599 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 523794000600 Carbon starvation protein CstA; Region: CstA; pfam02554 523794000601 Carbon starvation protein CstA; Region: CstA; pfam02554 523794000602 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 523794000603 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523794000604 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523794000605 active site 523794000606 metal binding site [ion binding]; metal-binding site 523794000607 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 523794000608 Divergent AAA domain; Region: AAA_4; pfam04326 523794000609 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 523794000610 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 523794000611 S17 interaction site [polypeptide binding]; other site 523794000612 S8 interaction site; other site 523794000613 16S rRNA interaction site [nucleotide binding]; other site 523794000614 streptomycin interaction site [chemical binding]; other site 523794000615 23S rRNA interaction site [nucleotide binding]; other site 523794000616 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 523794000617 30S ribosomal protein S7; Validated; Region: PRK05302 523794000618 elongation factor G; Reviewed; Region: PRK00007 523794000619 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 523794000620 G1 box; other site 523794000621 putative GEF interaction site [polypeptide binding]; other site 523794000622 GTP/Mg2+ binding site [chemical binding]; other site 523794000623 Switch I region; other site 523794000624 G2 box; other site 523794000625 G3 box; other site 523794000626 Switch II region; other site 523794000627 G4 box; other site 523794000628 G5 box; other site 523794000629 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 523794000630 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 523794000631 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 523794000632 elongation factor Tu; Reviewed; Region: PRK00049 523794000633 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 523794000634 G1 box; other site 523794000635 GEF interaction site [polypeptide binding]; other site 523794000636 GTP/Mg2+ binding site [chemical binding]; other site 523794000637 Switch I region; other site 523794000638 G2 box; other site 523794000639 G3 box; other site 523794000640 Switch II region; other site 523794000641 G4 box; other site 523794000642 G5 box; other site 523794000643 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 523794000644 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 523794000645 Antibiotic Binding Site [chemical binding]; other site 523794000646 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 523794000647 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 523794000648 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 523794000649 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 523794000650 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 523794000651 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 523794000652 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 523794000653 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 523794000654 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 523794000655 putative translocon binding site; other site 523794000656 protein-rRNA interface [nucleotide binding]; other site 523794000657 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 523794000658 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 523794000659 G-X-X-G motif; other site 523794000660 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 523794000661 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 523794000662 23S rRNA interface [nucleotide binding]; other site 523794000663 5S rRNA interface [nucleotide binding]; other site 523794000664 putative antibiotic binding site [chemical binding]; other site 523794000665 L25 interface [polypeptide binding]; other site 523794000666 L27 interface [polypeptide binding]; other site 523794000667 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 523794000668 L23 interface [polypeptide binding]; other site 523794000669 signal recognition particle (SRP54) interaction site; other site 523794000670 trigger factor interaction site; other site 523794000671 23S rRNA interface [nucleotide binding]; other site 523794000672 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 523794000673 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 523794000674 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 523794000675 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 523794000676 RNA binding site [nucleotide binding]; other site 523794000677 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 523794000678 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 523794000679 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 523794000680 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 523794000681 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 523794000682 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 523794000683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523794000684 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 523794000685 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 523794000686 23S rRNA interface [nucleotide binding]; other site 523794000687 L21e interface [polypeptide binding]; other site 523794000688 5S rRNA interface [nucleotide binding]; other site 523794000689 L27 interface [polypeptide binding]; other site 523794000690 L5 interface [polypeptide binding]; other site 523794000691 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 523794000692 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 523794000693 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 523794000694 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 523794000695 23S rRNA binding site [nucleotide binding]; other site 523794000696 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 523794000697 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 523794000698 SecY translocase; Region: SecY; pfam00344 523794000699 Bacterial SH3 domain; Region: SH3_3; cl17532 523794000700 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 523794000701 YARHG domain; Region: YARHG; pfam13308 523794000702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 523794000703 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 523794000704 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 523794000705 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 523794000706 Walker A/P-loop; other site 523794000707 ATP binding site [chemical binding]; other site 523794000708 Q-loop/lid; other site 523794000709 ABC transporter signature motif; other site 523794000710 Walker B; other site 523794000711 D-loop; other site 523794000712 H-loop/switch region; other site 523794000713 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 523794000714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794000715 catalytic core [active] 523794000716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794000717 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 523794000718 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 523794000719 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 523794000720 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 523794000721 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 523794000722 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 523794000723 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 523794000724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794000725 Walker A/P-loop; other site 523794000726 ATP binding site [chemical binding]; other site 523794000727 Q-loop/lid; other site 523794000728 ABC transporter signature motif; other site 523794000729 Walker B; other site 523794000730 D-loop; other site 523794000731 H-loop/switch region; other site 523794000732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523794000733 putative substrate translocation pore; other site 523794000734 peroxiredoxin; Region: AhpC; TIGR03137 523794000735 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 523794000736 dimer interface [polypeptide binding]; other site 523794000737 decamer (pentamer of dimers) interface [polypeptide binding]; other site 523794000738 catalytic triad [active] 523794000739 peroxidatic and resolving cysteines [active] 523794000740 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 523794000741 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 523794000742 catalytic residue [active] 523794000743 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 523794000744 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794000745 catalytic residues [active] 523794000746 TraX protein; Region: TraX; cl05434 523794000747 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523794000748 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 523794000749 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 523794000750 putative acyl-acceptor binding pocket; other site 523794000751 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 523794000752 B12 binding site [chemical binding]; other site 523794000753 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 523794000754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794000755 FeS/SAM binding site; other site 523794000756 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 523794000757 B12 binding site [chemical binding]; other site 523794000758 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 523794000759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794000760 FeS/SAM binding site; other site 523794000761 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 523794000762 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 523794000763 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 523794000764 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 523794000765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794000766 FeS/SAM binding site; other site 523794000767 GH3 auxin-responsive promoter; Region: GH3; pfam03321 523794000768 GH3 auxin-responsive promoter; Region: GH3; pfam03321 523794000769 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 523794000770 B12 binding site [chemical binding]; other site 523794000771 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 523794000772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794000773 FeS/SAM binding site; other site 523794000774 Methyltransferase domain; Region: Methyltransf_26; pfam13659 523794000775 SurA N-terminal domain; Region: SurA_N_3; cl07813 523794000776 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 523794000777 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 523794000778 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523794000779 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523794000780 active site 523794000781 metal binding site [ion binding]; metal-binding site 523794000782 Preprotein translocase subunit; Region: YajC; cl00806 523794000783 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 523794000784 Phosphoglycerate kinase; Region: PGK; pfam00162 523794000785 substrate binding site [chemical binding]; other site 523794000786 hinge regions; other site 523794000787 ADP binding site [chemical binding]; other site 523794000788 catalytic site [active] 523794000789 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 523794000790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794000791 Coenzyme A binding pocket [chemical binding]; other site 523794000792 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523794000793 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523794000794 Walker A/P-loop; other site 523794000795 ATP binding site [chemical binding]; other site 523794000796 Q-loop/lid; other site 523794000797 ABC transporter signature motif; other site 523794000798 Walker B; other site 523794000799 D-loop; other site 523794000800 H-loop/switch region; other site 523794000801 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 523794000802 putative ADP-ribose binding site [chemical binding]; other site 523794000803 putative active site [active] 523794000804 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523794000805 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523794000806 Walker A/P-loop; other site 523794000807 ATP binding site [chemical binding]; other site 523794000808 Q-loop/lid; other site 523794000809 ABC transporter signature motif; other site 523794000810 Walker B; other site 523794000811 D-loop; other site 523794000812 H-loop/switch region; other site 523794000813 Cobalt transport protein; Region: CbiQ; cl00463 523794000814 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 523794000815 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 523794000816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794000817 active site 523794000818 motif I; other site 523794000819 motif II; other site 523794000820 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 523794000821 metal ion-dependent adhesion site (MIDAS); other site 523794000822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523794000823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523794000824 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 523794000825 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523794000826 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 523794000827 HlyD family secretion protein; Region: HlyD_3; pfam13437 523794000828 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 523794000829 Protein export membrane protein; Region: SecD_SecF; cl14618 523794000830 cell division protein FtsZ; Region: ftsZ; TIGR00065 523794000831 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 523794000832 nucleotide binding site [chemical binding]; other site 523794000833 Cache domain; Region: Cache_1; pfam02743 523794000834 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 523794000835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794000836 dimerization interface [polypeptide binding]; other site 523794000837 Histidine kinase; Region: His_kinase; pfam06580 523794000838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794000839 ATP binding site [chemical binding]; other site 523794000840 Mg2+ binding site [ion binding]; other site 523794000841 G-X-G motif; other site 523794000842 Response regulator receiver domain; Region: Response_reg; pfam00072 523794000843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794000844 active site 523794000845 phosphorylation site [posttranslational modification] 523794000846 intermolecular recognition site; other site 523794000847 dimerization interface [polypeptide binding]; other site 523794000848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523794000849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523794000850 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523794000851 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523794000852 catalytic residues [active] 523794000853 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 523794000854 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 523794000855 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 523794000856 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 523794000857 SelR domain; Region: SelR; pfam01641 523794000858 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 523794000859 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 523794000860 active site 523794000861 nucleotide binding site [chemical binding]; other site 523794000862 HIGH motif; other site 523794000863 KMSKS motif; other site 523794000864 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 523794000865 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 523794000866 Glycoprotease family; Region: Peptidase_M22; pfam00814 523794000867 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 523794000868 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 523794000869 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 523794000870 GTP binding site [chemical binding]; other site 523794000871 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 523794000872 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 523794000873 propionate/acetate kinase; Provisional; Region: PRK12379 523794000874 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523794000875 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 523794000876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 523794000877 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 523794000878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794000879 Walker A motif; other site 523794000880 ATP binding site [chemical binding]; other site 523794000881 Walker B motif; other site 523794000882 arginine finger; other site 523794000883 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 523794000884 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 523794000885 Oligomerisation domain; Region: Oligomerisation; pfam02410 523794000886 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 523794000887 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 523794000888 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523794000889 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 523794000890 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 523794000891 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 523794000892 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 523794000893 Divergent PAP2 family; Region: DUF212; pfam02681 523794000894 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794000895 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 523794000896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794000897 RNA binding surface [nucleotide binding]; other site 523794000898 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 523794000899 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 523794000900 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 523794000901 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 523794000902 protein binding site [polypeptide binding]; other site 523794000903 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 523794000904 Catalytic dyad [active] 523794000905 Predicted methyltransferases [General function prediction only]; Region: COG0313 523794000906 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 523794000907 putative SAM binding site [chemical binding]; other site 523794000908 putative homodimer interface [polypeptide binding]; other site 523794000909 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 523794000910 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 523794000911 GTP/Mg2+ binding site [chemical binding]; other site 523794000912 G4 box; other site 523794000913 G5 box; other site 523794000914 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 523794000915 G1 box; other site 523794000916 G1 box; other site 523794000917 GTP/Mg2+ binding site [chemical binding]; other site 523794000918 Switch I region; other site 523794000919 G2 box; other site 523794000920 G2 box; other site 523794000921 G3 box; other site 523794000922 G3 box; other site 523794000923 Switch II region; other site 523794000924 Switch II region; other site 523794000925 G4 box; other site 523794000926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523794000927 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 523794000928 putative ADP-binding pocket [chemical binding]; other site 523794000929 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 523794000930 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 523794000931 Cupin domain; Region: Cupin_2; cl17218 523794000932 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794000933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794000934 substrate binding pocket [chemical binding]; other site 523794000935 membrane-bound complex binding site; other site 523794000936 hinge residues; other site 523794000937 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794000938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794000939 substrate binding pocket [chemical binding]; other site 523794000940 membrane-bound complex binding site; other site 523794000941 hinge residues; other site 523794000942 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 523794000943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000944 dimer interface [polypeptide binding]; other site 523794000945 conserved gate region; other site 523794000946 putative PBP binding loops; other site 523794000947 ABC-ATPase subunit interface; other site 523794000948 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794000949 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794000950 Walker A/P-loop; other site 523794000951 ATP binding site [chemical binding]; other site 523794000952 Q-loop/lid; other site 523794000953 ABC transporter signature motif; other site 523794000954 Walker B; other site 523794000955 D-loop; other site 523794000956 H-loop/switch region; other site 523794000957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000958 dimer interface [polypeptide binding]; other site 523794000959 conserved gate region; other site 523794000960 putative PBP binding loops; other site 523794000961 ABC-ATPase subunit interface; other site 523794000962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794000963 dimer interface [polypeptide binding]; other site 523794000964 conserved gate region; other site 523794000965 putative PBP binding loops; other site 523794000966 ABC-ATPase subunit interface; other site 523794000967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794000968 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794000969 Walker A/P-loop; other site 523794000970 ATP binding site [chemical binding]; other site 523794000971 Q-loop/lid; other site 523794000972 ABC transporter signature motif; other site 523794000973 Walker B; other site 523794000974 D-loop; other site 523794000975 H-loop/switch region; other site 523794000976 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 523794000977 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 523794000978 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523794000979 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 523794000980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794000981 substrate binding pocket [chemical binding]; other site 523794000982 membrane-bound complex binding site; other site 523794000983 hinge residues; other site 523794000984 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 523794000985 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 523794000986 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 523794000987 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 523794000988 RNA binding site [nucleotide binding]; other site 523794000989 L-lactate permease; Region: Lactate_perm; cl00701 523794000990 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 523794000991 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 523794000992 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 523794000993 HIGH motif; other site 523794000994 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523794000995 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 523794000996 active site 523794000997 KMSKS motif; other site 523794000998 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 523794000999 tRNA binding surface [nucleotide binding]; other site 523794001000 anticodon binding site; other site 523794001001 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 523794001002 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 523794001003 lipoprotein signal peptidase; Provisional; Region: PRK14787 523794001004 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 523794001005 dimer interface [polypeptide binding]; other site 523794001006 motif 1; other site 523794001007 active site 523794001008 motif 2; other site 523794001009 motif 3; other site 523794001010 AAA domain; Region: AAA_21; pfam13304 523794001011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794001012 Walker B; other site 523794001013 D-loop; other site 523794001014 H-loop/switch region; other site 523794001015 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 523794001016 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 523794001017 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 523794001018 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794001019 ligand binding site [chemical binding]; other site 523794001020 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794001021 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 523794001022 dimerization domain swap beta strand [polypeptide binding]; other site 523794001023 regulatory protein interface [polypeptide binding]; other site 523794001024 active site 523794001025 regulatory phosphorylation site [posttranslational modification]; other site 523794001026 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 523794001027 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 523794001028 RNA binding site [nucleotide binding]; other site 523794001029 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 523794001030 RNA binding site [nucleotide binding]; other site 523794001031 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523794001032 RNA binding site [nucleotide binding]; other site 523794001033 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 523794001034 RNA binding site [nucleotide binding]; other site 523794001035 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 523794001036 RNA binding site [nucleotide binding]; other site 523794001037 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 523794001038 RNA binding site [nucleotide binding]; other site 523794001039 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 523794001040 RNA binding site [nucleotide binding]; other site 523794001041 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 523794001042 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 523794001043 homodimer interface [polypeptide binding]; other site 523794001044 substrate-cofactor binding pocket; other site 523794001045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794001046 catalytic residue [active] 523794001047 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 523794001048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523794001049 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 523794001050 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523794001051 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 523794001052 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 523794001053 Walker A/P-loop; other site 523794001054 ATP binding site [chemical binding]; other site 523794001055 Q-loop/lid; other site 523794001056 ABC transporter signature motif; other site 523794001057 Walker B; other site 523794001058 D-loop; other site 523794001059 H-loop/switch region; other site 523794001060 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 523794001061 L-aspartate oxidase; Provisional; Region: PRK06175 523794001062 Ferredoxin [Energy production and conversion]; Region: COG1146 523794001063 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 523794001064 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 523794001065 Active Sites [active] 523794001066 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 523794001067 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 523794001068 CysD dimerization site [polypeptide binding]; other site 523794001069 G1 box; other site 523794001070 putative GEF interaction site [polypeptide binding]; other site 523794001071 GTP/Mg2+ binding site [chemical binding]; other site 523794001072 Switch I region; other site 523794001073 G2 box; other site 523794001074 G3 box; other site 523794001075 Switch II region; other site 523794001076 G4 box; other site 523794001077 G5 box; other site 523794001078 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 523794001079 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 523794001080 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 523794001081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794001082 membrane-bound complex binding site; other site 523794001083 hinge residues; other site 523794001084 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 523794001085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794001086 dimer interface [polypeptide binding]; other site 523794001087 conserved gate region; other site 523794001088 putative PBP binding loops; other site 523794001089 ABC-ATPase subunit interface; other site 523794001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794001091 dimer interface [polypeptide binding]; other site 523794001092 conserved gate region; other site 523794001093 ABC-ATPase subunit interface; other site 523794001094 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 523794001095 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 523794001096 dimer interface [polypeptide binding]; other site 523794001097 PYR/PP interface [polypeptide binding]; other site 523794001098 TPP binding site [chemical binding]; other site 523794001099 substrate binding site [chemical binding]; other site 523794001100 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 523794001101 Domain of unknown function; Region: EKR; pfam10371 523794001102 4Fe-4S binding domain; Region: Fer4_6; pfam12837 523794001103 4Fe-4S binding domain; Region: Fer4; pfam00037 523794001104 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 523794001105 TPP-binding site [chemical binding]; other site 523794001106 dimer interface [polypeptide binding]; other site 523794001107 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 523794001108 DHH family; Region: DHH; pfam01368 523794001109 DHHA1 domain; Region: DHHA1; pfam02272 523794001110 putative lipid kinase; Reviewed; Region: PRK13059 523794001111 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 523794001112 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 523794001113 Uncharacterized conserved protein [Function unknown]; Region: COG1543 523794001114 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 523794001115 active site 523794001116 substrate binding site [chemical binding]; other site 523794001117 catalytic site [active] 523794001118 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 523794001119 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523794001120 catalytic residues [active] 523794001121 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 523794001122 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 523794001123 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523794001124 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 523794001125 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 523794001126 FeoA domain; Region: FeoA; cl00838 523794001127 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 523794001128 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 523794001129 active site 523794001130 catalytic residues [active] 523794001131 DNA binding site [nucleotide binding] 523794001132 Int/Topo IB signature motif; other site 523794001133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523794001134 non-specific DNA binding site [nucleotide binding]; other site 523794001135 salt bridge; other site 523794001136 sequence-specific DNA binding site [nucleotide binding]; other site 523794001137 Replication protein; Region: Rep_1; cl02412 523794001138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523794001139 non-specific DNA binding site [nucleotide binding]; other site 523794001140 salt bridge; other site 523794001141 sequence-specific DNA binding site [nucleotide binding]; other site 523794001142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 523794001143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523794001144 non-specific DNA binding site [nucleotide binding]; other site 523794001145 salt bridge; other site 523794001146 sequence-specific DNA binding site [nucleotide binding]; other site 523794001147 Uncharacterized conserved protein [Function unknown]; Region: COG1479 523794001148 Protein of unknown function DUF262; Region: DUF262; pfam03235 523794001149 BetR domain; Region: BetR; pfam08667 523794001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523794001151 non-specific DNA binding site [nucleotide binding]; other site 523794001152 salt bridge; other site 523794001153 sequence-specific DNA binding site [nucleotide binding]; other site 523794001154 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 523794001155 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 523794001156 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 523794001157 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 523794001158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794001159 S-adenosylmethionine binding site [chemical binding]; other site 523794001160 Protein of unknown function, DUF488; Region: DUF488; cl01246 523794001161 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 523794001162 putative active site [active] 523794001163 nucleotide binding site [chemical binding]; other site 523794001164 nudix motif; other site 523794001165 putative metal binding site [ion binding]; other site 523794001166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 523794001167 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 523794001168 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 523794001169 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 523794001170 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 523794001171 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 523794001172 active site 523794001173 SAM binding site [chemical binding]; other site 523794001174 homodimer interface [polypeptide binding]; other site 523794001175 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 523794001176 argininosuccinate synthase; Provisional; Region: PRK13820 523794001177 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 523794001178 ANP binding site [chemical binding]; other site 523794001179 Substrate Binding Site II [chemical binding]; other site 523794001180 Substrate Binding Site I [chemical binding]; other site 523794001181 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 523794001182 active site 523794001183 TraX protein; Region: TraX; cl05434 523794001184 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 523794001185 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523794001186 minor groove reading motif; other site 523794001187 helix-hairpin-helix signature motif; other site 523794001188 substrate binding pocket [chemical binding]; other site 523794001189 active site 523794001190 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 523794001191 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 523794001192 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 523794001193 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 523794001194 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794001195 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794001196 ligand binding site [chemical binding]; other site 523794001197 OstA-like protein; Region: OstA; cl00844 523794001198 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 523794001199 TrkA-N domain; Region: TrkA_N; pfam02254 523794001200 TrkA-C domain; Region: TrkA_C; pfam02080 523794001201 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 523794001202 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 523794001203 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523794001204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523794001205 putative DNA binding site [nucleotide binding]; other site 523794001206 putative Zn2+ binding site [ion binding]; other site 523794001207 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 523794001208 GTP-binding protein Der; Reviewed; Region: PRK00093 523794001209 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 523794001210 G1 box; other site 523794001211 GTP/Mg2+ binding site [chemical binding]; other site 523794001212 Switch I region; other site 523794001213 G2 box; other site 523794001214 Switch II region; other site 523794001215 G3 box; other site 523794001216 G4 box; other site 523794001217 G5 box; other site 523794001218 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 523794001219 G1 box; other site 523794001220 GTP/Mg2+ binding site [chemical binding]; other site 523794001221 Switch I region; other site 523794001222 G2 box; other site 523794001223 G3 box; other site 523794001224 Switch II region; other site 523794001225 G4 box; other site 523794001226 G5 box; other site 523794001227 Protein of unknown function (DUF441); Region: DUF441; pfam04284 523794001228 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 523794001229 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 523794001230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523794001231 ABC-ATPase subunit interface; other site 523794001232 dimer interface [polypeptide binding]; other site 523794001233 putative PBP binding regions; other site 523794001234 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 523794001235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 523794001236 ABC-ATPase subunit interface; other site 523794001237 dimer interface [polypeptide binding]; other site 523794001238 putative PBP binding regions; other site 523794001239 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523794001240 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 523794001241 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 523794001242 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 523794001243 metal binding site [ion binding]; metal-binding site 523794001244 intersubunit interface [polypeptide binding]; other site 523794001245 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 523794001246 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 523794001247 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 523794001248 FeoA domain; Region: FeoA; pfam04023 523794001249 BioY family; Region: BioY; pfam02632 523794001250 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 523794001251 oligomer interface [polypeptide binding]; other site 523794001252 tandem repeat interface [polypeptide binding]; other site 523794001253 active site residues [active] 523794001254 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 523794001255 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 523794001256 tandem repeat interface [polypeptide binding]; other site 523794001257 oligomer interface [polypeptide binding]; other site 523794001258 active site residues [active] 523794001259 Sugar fermentation stimulation protein; Region: SfsA; cl00647 523794001260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523794001261 HSP70 interaction site [polypeptide binding]; other site 523794001262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 523794001263 phosphopeptide binding site; other site 523794001264 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523794001265 phosphopeptide binding site; other site 523794001266 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 523794001267 active site 523794001268 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523794001269 active site 523794001270 ATP binding site [chemical binding]; other site 523794001271 substrate binding site [chemical binding]; other site 523794001272 activation loop (A-loop); other site 523794001273 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 523794001274 nucleotide binding site [chemical binding]; other site 523794001275 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 523794001276 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 523794001277 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 523794001278 putative active site [active] 523794001279 putative metal binding site [ion binding]; other site 523794001280 Domain of unknown function (DUF956); Region: DUF956; cl01917 523794001281 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 523794001282 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 523794001283 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 523794001284 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 523794001285 active pocket/dimerization site; other site 523794001286 active site 523794001287 phosphorylation site [posttranslational modification] 523794001288 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 523794001289 active site 523794001290 phosphorylation site [posttranslational modification] 523794001291 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 523794001292 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 523794001293 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 523794001294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523794001295 catalytic residue [active] 523794001296 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523794001297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 523794001298 active site 523794001299 metal binding site [ion binding]; metal-binding site 523794001300 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 523794001301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794001302 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794001303 active site 523794001304 motif I; other site 523794001305 motif II; other site 523794001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794001307 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 523794001308 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 523794001309 active site 523794001310 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 523794001311 generic binding surface II; other site 523794001312 generic binding surface I; other site 523794001313 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 523794001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794001315 S-adenosylmethionine binding site [chemical binding]; other site 523794001316 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 523794001317 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 523794001318 substrate binding pocket [chemical binding]; other site 523794001319 chain length determination region; other site 523794001320 substrate-Mg2+ binding site; other site 523794001321 catalytic residues [active] 523794001322 aspartate-rich region 1; other site 523794001323 active site lid residues [active] 523794001324 aspartate-rich region 2; other site 523794001325 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 523794001326 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 523794001327 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 523794001328 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 523794001329 homotrimer interface [polypeptide binding]; other site 523794001330 Walker A motif; other site 523794001331 GTP binding site [chemical binding]; other site 523794001332 Walker B motif; other site 523794001333 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 523794001334 elongation factor G; Reviewed; Region: PRK12740 523794001335 G1 box; other site 523794001336 putative GEF interaction site [polypeptide binding]; other site 523794001337 GTP/Mg2+ binding site [chemical binding]; other site 523794001338 Switch I region; other site 523794001339 G2 box; other site 523794001340 G3 box; other site 523794001341 Switch II region; other site 523794001342 G4 box; other site 523794001343 G5 box; other site 523794001344 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 523794001345 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 523794001346 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 523794001347 Spherulation-specific family 4; Region: Spherulin4; pfam12138 523794001348 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 523794001349 glycerol kinase; Provisional; Region: glpK; PRK00047 523794001350 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 523794001351 N- and C-terminal domain interface [polypeptide binding]; other site 523794001352 active site 523794001353 MgATP binding site [chemical binding]; other site 523794001354 catalytic site [active] 523794001355 metal binding site [ion binding]; metal-binding site 523794001356 glycerol binding site [chemical binding]; other site 523794001357 homotetramer interface [polypeptide binding]; other site 523794001358 homodimer interface [polypeptide binding]; other site 523794001359 FBP binding site [chemical binding]; other site 523794001360 protein IIAGlc interface [polypeptide binding]; other site 523794001361 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 523794001362 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 523794001363 Cl- selectivity filter; other site 523794001364 Cl- binding residues [ion binding]; other site 523794001365 pore gating glutamate residue; other site 523794001366 dimer interface [polypeptide binding]; other site 523794001367 H+/Cl- coupling transport residue; other site 523794001368 TrkA-C domain; Region: TrkA_C; pfam02080 523794001369 ApbE family; Region: ApbE; pfam02424 523794001370 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794001371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794001372 Probable transposase; Region: OrfB_IS605; pfam01385 523794001373 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 523794001374 Transposase IS200 like; Region: Y1_Tnp; pfam01797 523794001375 ATP-NAD kinase; Region: NAD_kinase; pfam01513 523794001376 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 523794001377 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 523794001378 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523794001379 Walker A/P-loop; other site 523794001380 ATP binding site [chemical binding]; other site 523794001381 Q-loop/lid; other site 523794001382 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 523794001383 ABC transporter signature motif; other site 523794001384 Walker B; other site 523794001385 D-loop; other site 523794001386 H-loop/switch region; other site 523794001387 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523794001388 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 523794001389 active site 523794001390 DNA binding site [nucleotide binding] 523794001391 Int/Topo IB signature motif; other site 523794001392 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 523794001393 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 523794001394 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 523794001395 hinge; other site 523794001396 active site 523794001397 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 523794001398 FAD binding site [chemical binding]; other site 523794001399 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 523794001400 dimer interface [polypeptide binding]; other site 523794001401 substrate binding site [chemical binding]; other site 523794001402 ATP binding site [chemical binding]; other site 523794001403 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 523794001404 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 523794001405 Walker A/P-loop; other site 523794001406 ATP binding site [chemical binding]; other site 523794001407 Q-loop/lid; other site 523794001408 ABC transporter signature motif; other site 523794001409 Walker B; other site 523794001410 D-loop; other site 523794001411 H-loop/switch region; other site 523794001412 FeS assembly protein SufB; Region: sufB; TIGR01980 523794001413 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 523794001414 FeS assembly protein SufD; Region: sufD; TIGR01981 523794001415 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 523794001416 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 523794001417 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 523794001418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523794001419 catalytic residue [active] 523794001420 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 523794001421 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 523794001422 trimerization site [polypeptide binding]; other site 523794001423 active site 523794001424 DNA polymerase III PolC; Validated; Region: polC; PRK00448 523794001425 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 523794001426 generic binding surface II; other site 523794001427 generic binding surface I; other site 523794001428 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 523794001429 active site 523794001430 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 523794001431 active site 523794001432 catalytic site [active] 523794001433 substrate binding site [chemical binding]; other site 523794001434 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 523794001435 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 523794001436 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 523794001437 Potassium binding sites [ion binding]; other site 523794001438 Cesium cation binding sites [ion binding]; other site 523794001439 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 523794001440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794001441 AAA domain; Region: AAA_21; pfam13304 523794001442 Walker A/P-loop; other site 523794001443 ATP binding site [chemical binding]; other site 523794001444 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 523794001445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794001446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794001447 homodimer interface [polypeptide binding]; other site 523794001448 catalytic residue [active] 523794001449 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 523794001450 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 523794001451 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 523794001452 active site 523794001453 putative homodimer interface [polypeptide binding]; other site 523794001454 SAM binding site [chemical binding]; other site 523794001455 AAA domain; Region: AAA_21; pfam13304 523794001456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794001457 Walker B; other site 523794001458 D-loop; other site 523794001459 H-loop/switch region; other site 523794001460 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 523794001461 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 523794001462 HIGH motif; other site 523794001463 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523794001464 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 523794001465 active site 523794001466 KMSKS motif; other site 523794001467 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 523794001468 tRNA binding surface [nucleotide binding]; other site 523794001469 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 523794001470 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 523794001471 NADP binding site [chemical binding]; other site 523794001472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523794001473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523794001474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523794001475 dimerization interface [polypeptide binding]; other site 523794001476 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 523794001477 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 523794001478 THF binding site; other site 523794001479 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 523794001480 substrate binding site [chemical binding]; other site 523794001481 THF binding site; other site 523794001482 zinc-binding site [ion binding]; other site 523794001483 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 523794001484 substrate binding site [chemical binding]; other site 523794001485 THF binding site; other site 523794001486 zinc-binding site [ion binding]; other site 523794001487 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 523794001488 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 523794001489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523794001490 catalytic residue [active] 523794001491 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 523794001492 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 523794001493 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 523794001494 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 523794001495 Substrate binding site; other site 523794001496 Cupin domain; Region: Cupin_2; cl17218 523794001497 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 523794001498 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 523794001499 putative active site [active] 523794001500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 523794001501 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 523794001502 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 523794001503 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 523794001504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523794001505 active site 523794001506 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 523794001507 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 523794001508 Ligand Binding Site [chemical binding]; other site 523794001509 Transposase; Region: HTH_Tnp_1; pfam01527 523794001510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 523794001511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 523794001512 Transposase; Region: HTH_Tnp_1; cl17663 523794001513 Helix-turn-helix domain; Region: HTH_28; pfam13518 523794001514 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 523794001515 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 523794001516 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 523794001517 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 523794001518 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 523794001519 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 523794001520 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 523794001521 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 523794001522 active site 523794001523 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 523794001524 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857 523794001525 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 523794001526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794001527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794001528 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 523794001529 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 523794001530 NlpC/P60 family; Region: NLPC_P60; pfam00877 523794001531 META domain; Region: META; pfam03724 523794001532 META domain; Region: META; pfam03724 523794001533 META domain; Region: META; pfam03724 523794001534 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 523794001535 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 523794001536 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 523794001537 oligomer interface [polypeptide binding]; other site 523794001538 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 523794001539 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 523794001540 tetramer interface [polypeptide binding]; other site 523794001541 TPP-binding site [chemical binding]; other site 523794001542 heterodimer interface [polypeptide binding]; other site 523794001543 phosphorylation loop region [posttranslational modification] 523794001544 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 523794001545 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 523794001546 alpha subunit interface [polypeptide binding]; other site 523794001547 TPP binding site [chemical binding]; other site 523794001548 heterodimer interface [polypeptide binding]; other site 523794001549 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523794001550 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 523794001551 e3 binding domain; Region: E3_binding; pfam02817 523794001552 e3 binding domain; Region: E3_binding; pfam02817 523794001553 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 523794001554 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 523794001555 E3 interaction surface; other site 523794001556 lipoyl attachment site [posttranslational modification]; other site 523794001557 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 523794001558 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 523794001559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523794001560 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523794001561 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 523794001562 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 523794001563 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 523794001564 Uncharacterized conserved protein [Function unknown]; Region: COG2461 523794001565 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 523794001566 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 523794001567 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 523794001568 homodimer interface [polypeptide binding]; other site 523794001569 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 523794001570 active site pocket [active] 523794001571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794001572 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 523794001573 Walker A motif; other site 523794001574 ATP binding site [chemical binding]; other site 523794001575 Walker B motif; other site 523794001576 arginine finger; other site 523794001577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794001578 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 523794001579 Walker A motif; other site 523794001580 ATP binding site [chemical binding]; other site 523794001581 Walker B motif; other site 523794001582 arginine finger; other site 523794001583 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523794001584 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 523794001585 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 523794001586 peptide binding site [polypeptide binding]; other site 523794001587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523794001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794001589 dimer interface [polypeptide binding]; other site 523794001590 conserved gate region; other site 523794001591 ABC-ATPase subunit interface; other site 523794001592 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523794001593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794001594 dimer interface [polypeptide binding]; other site 523794001595 conserved gate region; other site 523794001596 putative PBP binding loops; other site 523794001597 ABC-ATPase subunit interface; other site 523794001598 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 523794001599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794001600 Walker A/P-loop; other site 523794001601 ATP binding site [chemical binding]; other site 523794001602 Q-loop/lid; other site 523794001603 ABC transporter signature motif; other site 523794001604 Walker B; other site 523794001605 D-loop; other site 523794001606 H-loop/switch region; other site 523794001607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523794001608 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 523794001609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794001610 Walker A/P-loop; other site 523794001611 ATP binding site [chemical binding]; other site 523794001612 Q-loop/lid; other site 523794001613 ABC transporter signature motif; other site 523794001614 Walker B; other site 523794001615 D-loop; other site 523794001616 H-loop/switch region; other site 523794001617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523794001618 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 523794001619 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 523794001620 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 523794001621 putative dimer interface [polypeptide binding]; other site 523794001622 active site pocket [active] 523794001623 putative cataytic base [active] 523794001624 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 523794001625 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523794001626 inhibitor-cofactor binding pocket; inhibition site 523794001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794001628 catalytic residue [active] 523794001629 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 523794001630 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 523794001631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523794001632 active site 523794001633 HIGH motif; other site 523794001634 nucleotide binding site [chemical binding]; other site 523794001635 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 523794001636 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 523794001637 active site 523794001638 KMSKS motif; other site 523794001639 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 523794001640 tRNA binding surface [nucleotide binding]; other site 523794001641 anticodon binding site; other site 523794001642 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 523794001643 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 523794001644 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 523794001645 HflK protein; Region: hflK; TIGR01933 523794001646 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 523794001647 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 523794001648 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 523794001649 putative substrate binding site [chemical binding]; other site 523794001650 putative ATP binding site [chemical binding]; other site 523794001651 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 523794001652 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523794001653 active site 523794001654 phosphorylation site [posttranslational modification] 523794001655 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 523794001656 active site 523794001657 P-loop; other site 523794001658 phosphorylation site [posttranslational modification] 523794001659 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 523794001660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794001661 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794001662 Probable transposase; Region: OrfB_IS605; pfam01385 523794001663 Transposase IS200 like; Region: Y1_Tnp; pfam01797 523794001664 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 523794001665 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 523794001666 N-terminal plug; other site 523794001667 ligand-binding site [chemical binding]; other site 523794001668 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 523794001669 dimer interface [polypeptide binding]; other site 523794001670 FMN binding site [chemical binding]; other site 523794001671 NADPH bind site [chemical binding]; other site 523794001672 Protein of unknown function, DUF479; Region: DUF479; cl01203 523794001673 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794001674 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523794001675 putative active site [active] 523794001676 catalytic site [active] 523794001677 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523794001678 PLD-like domain; Region: PLDc_2; pfam13091 523794001679 putative active site [active] 523794001680 catalytic site [active] 523794001681 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 523794001682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523794001683 active site 523794001684 metal binding site [ion binding]; metal-binding site 523794001685 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 523794001686 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 523794001687 G1 box; other site 523794001688 putative GEF interaction site [polypeptide binding]; other site 523794001689 GTP/Mg2+ binding site [chemical binding]; other site 523794001690 Switch I region; other site 523794001691 G2 box; other site 523794001692 G3 box; other site 523794001693 Switch II region; other site 523794001694 G4 box; other site 523794001695 G5 box; other site 523794001696 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 523794001697 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 523794001698 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523794001699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523794001700 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 523794001701 zinc binding site [ion binding]; other site 523794001702 putative ligand binding site [chemical binding]; other site 523794001703 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523794001704 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523794001705 DNA binding site [nucleotide binding] 523794001706 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 523794001707 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 523794001708 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 523794001709 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 523794001710 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 523794001711 putative substrate binding site [chemical binding]; other site 523794001712 putative ATP binding site [chemical binding]; other site 523794001713 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 523794001714 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 523794001715 methionine cluster; other site 523794001716 active site 523794001717 phosphorylation site [posttranslational modification] 523794001718 metal binding site [ion binding]; metal-binding site 523794001719 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 523794001720 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 523794001721 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 523794001722 active site 523794001723 P-loop; other site 523794001724 phosphorylation site [posttranslational modification] 523794001725 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 523794001726 beta-galactosidase; Region: BGL; TIGR03356 523794001727 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 523794001728 Penicillinase repressor; Region: Pencillinase_R; pfam03965 523794001729 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523794001730 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523794001731 metal-binding site [ion binding] 523794001732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523794001733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794001734 motif II; other site 523794001735 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 523794001736 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 523794001737 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 523794001738 MgtE intracellular N domain; Region: MgtE_N; smart00924 523794001739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 523794001740 Divalent cation transporter; Region: MgtE; pfam01769 523794001741 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 523794001742 MgtE intracellular N domain; Region: MgtE_N; smart00924 523794001743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 523794001744 Divalent cation transporter; Region: MgtE; pfam01769 523794001745 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523794001746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794001747 Coenzyme A binding pocket [chemical binding]; other site 523794001748 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 523794001749 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 523794001750 NAD binding site [chemical binding]; other site 523794001751 substrate binding site [chemical binding]; other site 523794001752 catalytic Zn binding site [ion binding]; other site 523794001753 tetramer interface [polypeptide binding]; other site 523794001754 structural Zn binding site [ion binding]; other site 523794001755 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 523794001756 AAA domain; Region: AAA_18; pfam13238 523794001757 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 523794001758 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 523794001759 GIY-YIG motif/motif A; other site 523794001760 active site 523794001761 catalytic site [active] 523794001762 putative DNA binding site [nucleotide binding]; other site 523794001763 metal binding site [ion binding]; metal-binding site 523794001764 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 523794001765 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 523794001766 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 523794001767 Walker A/P-loop; other site 523794001768 ATP binding site [chemical binding]; other site 523794001769 Q-loop/lid; other site 523794001770 ABC transporter signature motif; other site 523794001771 Walker B; other site 523794001772 D-loop; other site 523794001773 H-loop/switch region; other site 523794001774 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 523794001775 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 523794001776 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 523794001777 TM-ABC transporter signature motif; other site 523794001778 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 523794001779 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 523794001780 TM-ABC transporter signature motif; other site 523794001781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794001782 S-adenosylmethionine binding site [chemical binding]; other site 523794001783 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 523794001784 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 523794001785 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523794001786 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 523794001787 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 523794001788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 523794001789 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 523794001790 Cation efflux family; Region: Cation_efflux; pfam01545 523794001791 Domain of unknown function (DUF389); Region: DUF389; pfam04087 523794001792 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 523794001793 Pleckstrin homology-like domain; Region: PH-like; cl17171 523794001794 Short C-terminal domain; Region: SHOCT; pfam09851 523794001795 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 523794001796 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 523794001797 dimer interface [polypeptide binding]; other site 523794001798 active site 523794001799 CoA binding pocket [chemical binding]; other site 523794001800 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 523794001801 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 523794001802 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 523794001803 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 523794001804 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 523794001805 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 523794001806 putative ribose interaction site [chemical binding]; other site 523794001807 putative ADP binding site [chemical binding]; other site 523794001808 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 523794001809 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523794001810 nucleotide binding site [chemical binding]; other site 523794001811 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523794001812 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 523794001813 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 523794001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794001815 S-adenosylmethionine binding site [chemical binding]; other site 523794001816 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 523794001817 putative catalytic site [active] 523794001818 putative metal binding site [ion binding]; other site 523794001819 putative phosphate binding site [ion binding]; other site 523794001820 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 523794001821 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 523794001822 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 523794001823 heterotetramer interface [polypeptide binding]; other site 523794001824 active site pocket [active] 523794001825 cleavage site 523794001826 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 523794001827 feedback inhibition sensing region; other site 523794001828 homohexameric interface [polypeptide binding]; other site 523794001829 nucleotide binding site [chemical binding]; other site 523794001830 N-acetyl-L-glutamate binding site [chemical binding]; other site 523794001831 acetylornithine aminotransferase; Provisional; Region: PRK02627 523794001832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 523794001833 inhibitor-cofactor binding pocket; inhibition site 523794001834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794001835 catalytic residue [active] 523794001836 ornithine carbamoyltransferase; Validated; Region: PRK02102 523794001837 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523794001838 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523794001839 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 523794001840 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 523794001841 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 523794001842 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 523794001843 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 523794001844 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 523794001845 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 523794001846 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 523794001847 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 523794001848 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523794001849 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 523794001850 beta subunit interaction interface [polypeptide binding]; other site 523794001851 Walker A motif; other site 523794001852 ATP binding site [chemical binding]; other site 523794001853 Walker B motif; other site 523794001854 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523794001855 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 523794001856 core domain interface [polypeptide binding]; other site 523794001857 delta subunit interface [polypeptide binding]; other site 523794001858 epsilon subunit interface [polypeptide binding]; other site 523794001859 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 523794001860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523794001861 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 523794001862 alpha subunit interaction interface [polypeptide binding]; other site 523794001863 Walker A motif; other site 523794001864 ATP binding site [chemical binding]; other site 523794001865 Walker B motif; other site 523794001866 inhibitor binding site; inhibition site 523794001867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523794001868 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 523794001869 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 523794001870 gamma subunit interface [polypeptide binding]; other site 523794001871 epsilon subunit interface [polypeptide binding]; other site 523794001872 LBP interface [polypeptide binding]; other site 523794001873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 523794001874 Predicted membrane protein [Function unknown]; Region: COG2261 523794001875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 523794001876 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 523794001877 dimer interface [polypeptide binding]; other site 523794001878 active site 523794001879 metal binding site [ion binding]; metal-binding site 523794001880 glutathione binding site [chemical binding]; other site 523794001881 dihydrodipicolinate reductase; Provisional; Region: PRK00048 523794001882 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 523794001883 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 523794001884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 523794001885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 523794001886 active site 523794001887 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 523794001888 flavoprotein, HI0933 family; Region: TIGR00275 523794001889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523794001890 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 523794001891 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 523794001892 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 523794001893 TrkA-C domain; Region: TrkA_C; pfam02080 523794001894 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 523794001895 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 523794001896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794001897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794001898 homodimer interface [polypeptide binding]; other site 523794001899 catalytic residue [active] 523794001900 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794001901 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 523794001902 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794001903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794001904 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794001905 Protein of unknown function DUF45; Region: DUF45; pfam01863 523794001906 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 523794001907 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 523794001908 active site 523794001909 NTP binding site [chemical binding]; other site 523794001910 metal binding triad [ion binding]; metal-binding site 523794001911 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 523794001912 HD domain; Region: HD; pfam01966 523794001913 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 523794001914 active site 523794001915 Ap4A binding cleft/pocket [chemical binding]; other site 523794001916 P4 phosphate binding site; other site 523794001917 nudix motif; other site 523794001918 putative P2/P3 phosphate binding site [ion binding]; other site 523794001919 16S rRNA methyltransferase B; Provisional; Region: PRK14902 523794001920 putative RNA binding site [nucleotide binding]; other site 523794001921 NusB family; Region: NusB; pfam01029 523794001922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794001923 S-adenosylmethionine binding site [chemical binding]; other site 523794001924 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 523794001925 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 523794001926 substrate binding [chemical binding]; other site 523794001927 active site 523794001928 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 523794001929 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 523794001930 putative deacylase active site [active] 523794001931 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 523794001932 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 523794001933 active site 523794001934 substrate binding site [chemical binding]; other site 523794001935 trimer interface [polypeptide binding]; other site 523794001936 CoA binding site [chemical binding]; other site 523794001937 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794001938 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 523794001939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794001940 motif II; other site 523794001941 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 523794001942 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 523794001943 active site 523794001944 nucleophile elbow; other site 523794001945 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 523794001946 Surface antigen; Region: Bac_surface_Ag; pfam01103 523794001947 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 523794001948 homotrimer interaction site [polypeptide binding]; other site 523794001949 putative active site [active] 523794001950 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 523794001951 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 523794001952 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 523794001953 putative active site [active] 523794001954 catalytic site [active] 523794001955 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 523794001956 putative active site [active] 523794001957 catalytic site [active] 523794001958 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 523794001959 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 523794001960 RNA binding site [nucleotide binding]; other site 523794001961 active site 523794001962 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 523794001963 active site 523794001964 putative DNA-binding cleft [nucleotide binding]; other site 523794001965 dimer interface [polypeptide binding]; other site 523794001966 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 523794001967 thymidylate synthase; Reviewed; Region: thyA; PRK01827 523794001968 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 523794001969 dimerization interface [polypeptide binding]; other site 523794001970 active site 523794001971 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 523794001972 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 523794001973 folate binding site [chemical binding]; other site 523794001974 NADP+ binding site [chemical binding]; other site 523794001975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523794001976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523794001977 WHG domain; Region: WHG; pfam13305 523794001978 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 523794001979 putative acyl-acceptor binding pocket; other site 523794001980 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 523794001981 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 523794001982 active site 523794001983 HIGH motif; other site 523794001984 KMSKS motif; other site 523794001985 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 523794001986 anticodon binding site; other site 523794001987 tRNA binding surface [nucleotide binding]; other site 523794001988 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 523794001989 dimer interface [polypeptide binding]; other site 523794001990 putative tRNA-binding site [nucleotide binding]; other site 523794001991 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794001992 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523794001993 catalytic residues [active] 523794001994 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 523794001995 16S/18S rRNA binding site [nucleotide binding]; other site 523794001996 S13e-L30e interaction site [polypeptide binding]; other site 523794001997 25S rRNA binding site [nucleotide binding]; other site 523794001998 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 523794001999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 523794002000 putative acyl-acceptor binding pocket; other site 523794002001 phosphodiesterase; Provisional; Region: PRK12704 523794002002 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523794002003 Zn2+ binding site [ion binding]; other site 523794002004 Mg2+ binding site [ion binding]; other site 523794002005 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 523794002006 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523794002007 putative active site [active] 523794002008 metal binding site [ion binding]; metal-binding site 523794002009 homodimer binding site [polypeptide binding]; other site 523794002010 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 523794002011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 523794002012 S-adenosylmethionine binding site [chemical binding]; other site 523794002013 cytidylate kinase; Provisional; Region: cmk; PRK00023 523794002014 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 523794002015 CMP-binding site; other site 523794002016 The sites determining sugar specificity; other site 523794002017 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523794002018 IHF - DNA interface [nucleotide binding]; other site 523794002019 IHF dimer interface [polypeptide binding]; other site 523794002020 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 523794002021 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 523794002022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794002023 S-adenosylmethionine binding site [chemical binding]; other site 523794002024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794002025 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523794002026 S-adenosylmethionine binding site [chemical binding]; other site 523794002027 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 523794002028 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523794002029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 523794002030 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 523794002031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523794002032 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 523794002033 putative active site [active] 523794002034 dimerization interface [polypeptide binding]; other site 523794002035 putative tRNAtyr binding site [nucleotide binding]; other site 523794002036 NlpC/P60 family; Region: NLPC_P60; pfam00877 523794002037 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 523794002038 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 523794002039 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 523794002040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794002041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794002042 substrate binding pocket [chemical binding]; other site 523794002043 membrane-bound complex binding site; other site 523794002044 hinge residues; other site 523794002045 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 523794002046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794002047 dimer interface [polypeptide binding]; other site 523794002048 conserved gate region; other site 523794002049 putative PBP binding loops; other site 523794002050 ABC-ATPase subunit interface; other site 523794002051 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794002052 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794002053 Walker A/P-loop; other site 523794002054 ATP binding site [chemical binding]; other site 523794002055 Q-loop/lid; other site 523794002056 ABC transporter signature motif; other site 523794002057 Walker B; other site 523794002058 D-loop; other site 523794002059 H-loop/switch region; other site 523794002060 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 523794002061 putative catalytic site [active] 523794002062 putative metal binding site [ion binding]; other site 523794002063 putative phosphate binding site [ion binding]; other site 523794002064 DKNYY family; Region: DKNYY; pfam13644 523794002065 DKNYY family; Region: DKNYY; pfam13644 523794002066 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794002067 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 523794002068 intersubunit interface [polypeptide binding]; other site 523794002069 active site 523794002070 catalytic residue [active] 523794002071 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 523794002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523794002073 DNA-binding site [nucleotide binding]; DNA binding site 523794002074 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 523794002075 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 523794002076 classical (c) SDRs; Region: SDR_c; cd05233 523794002077 NAD(P) binding site [chemical binding]; other site 523794002078 active site 523794002079 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 523794002080 Cl binding site [ion binding]; other site 523794002081 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 523794002082 oligomer interface [polypeptide binding]; other site 523794002083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 523794002084 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 523794002085 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 523794002086 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 523794002087 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 523794002088 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 523794002089 prolyl-tRNA synthetase; Provisional; Region: PRK09194 523794002090 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 523794002091 dimer interface [polypeptide binding]; other site 523794002092 motif 1; other site 523794002093 active site 523794002094 motif 2; other site 523794002095 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 523794002096 putative deacylase active site [active] 523794002097 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523794002098 active site 523794002099 motif 3; other site 523794002100 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 523794002101 anticodon binding site; other site 523794002102 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 523794002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794002104 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 523794002105 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 523794002106 dimer interface [polypeptide binding]; other site 523794002107 active site 523794002108 metal binding site [ion binding]; metal-binding site 523794002109 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 523794002110 Clp amino terminal domain; Region: Clp_N; pfam02861 523794002111 Clp amino terminal domain; Region: Clp_N; pfam02861 523794002112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794002113 Walker A motif; other site 523794002114 ATP binding site [chemical binding]; other site 523794002115 Walker B motif; other site 523794002116 arginine finger; other site 523794002117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794002118 Walker A motif; other site 523794002119 ATP binding site [chemical binding]; other site 523794002120 Walker B motif; other site 523794002121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 523794002122 phosphopentomutase; Provisional; Region: PRK05362 523794002123 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 523794002124 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 523794002125 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 523794002126 nudix motif; other site 523794002127 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 523794002128 30S subunit binding site; other site 523794002129 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 523794002130 active site 523794002131 DNA binding site [nucleotide binding] 523794002132 YceG-like family; Region: YceG; pfam02618 523794002133 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 523794002134 dimerization interface [polypeptide binding]; other site 523794002135 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 523794002136 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 523794002137 Ligand Binding Site [chemical binding]; other site 523794002138 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 523794002139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794002140 Walker A motif; other site 523794002141 ATP binding site [chemical binding]; other site 523794002142 Walker B motif; other site 523794002143 arginine finger; other site 523794002144 Peptidase family M41; Region: Peptidase_M41; pfam01434 523794002145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002146 TPR motif; other site 523794002147 binding surface 523794002148 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 523794002149 DKNYY family; Region: DKNYY; pfam13644 523794002150 DKNYY family; Region: DKNYY; pfam13644 523794002151 DKNYY family; Region: DKNYY; pfam13644 523794002152 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 523794002153 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 523794002154 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 523794002155 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 523794002156 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 523794002157 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 523794002158 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 523794002159 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 523794002160 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 523794002161 DJ-1 family protein; Region: not_thiJ; TIGR01383 523794002162 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 523794002163 conserved cys residue [active] 523794002164 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 523794002165 MraW methylase family; Region: Methyltransf_5; cl17771 523794002166 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 523794002167 V-type ATP synthase subunit I; Validated; Region: PRK05771 523794002168 Carbon starvation protein CstA; Region: CstA; pfam02554 523794002169 V-type ATP synthase subunit K; Validated; Region: PRK06558 523794002170 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 523794002171 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 523794002172 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 523794002173 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 523794002174 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 523794002175 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 523794002176 V-type ATP synthase subunit F; Provisional; Region: PRK01395 523794002177 V-type ATP synthase subunit A; Provisional; Region: PRK04192 523794002178 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523794002179 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 523794002180 Walker A motif/ATP binding site; other site 523794002181 Walker B motif; other site 523794002182 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523794002183 V-type ATP synthase subunit B; Provisional; Region: PRK04196 523794002184 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 523794002185 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 523794002186 Walker A motif homologous position; other site 523794002187 Walker B motif; other site 523794002188 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 523794002189 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 523794002190 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 523794002191 S-adenosylmethionine synthetase; Validated; Region: PRK05250 523794002192 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 523794002193 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 523794002194 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794002195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794002196 binding surface 523794002197 TPR motif; other site 523794002198 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 523794002199 putative active site [active] 523794002200 putative catalytic site [active] 523794002201 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 523794002202 PLD-like domain; Region: PLDc_2; pfam13091 523794002203 putative active site [active] 523794002204 putative catalytic site [active] 523794002205 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 523794002206 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794002207 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 523794002208 putative active site [active] 523794002209 putative catalytic site [active] 523794002210 putative Mg binding site IVb [ion binding]; other site 523794002211 putative phosphate binding site [ion binding]; other site 523794002212 putative DNA binding site [nucleotide binding]; other site 523794002213 putative Mg binding site IVa [ion binding]; other site 523794002214 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 523794002215 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 523794002216 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 523794002217 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 523794002218 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 523794002219 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 523794002220 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 523794002221 active site 523794002222 dimer interface [polypeptide binding]; other site 523794002223 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523794002224 dihydroorotase; Reviewed; Region: PRK09236 523794002225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 523794002226 active site 523794002227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794002228 active site 523794002229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794002230 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794002231 active site 523794002232 motif I; other site 523794002233 motif II; other site 523794002234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794002235 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 523794002236 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 523794002237 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 523794002238 Predicted kinase [General function prediction only]; Region: COG4639 523794002239 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523794002240 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 523794002241 active site 523794002242 metal binding site [ion binding]; metal-binding site 523794002243 RNA ligase; Region: RNA_lig_T4_1; pfam09511 523794002244 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 523794002245 NlpC/P60 family; Region: NLPC_P60; pfam00877 523794002246 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 523794002247 catalytic triad [active] 523794002248 putative active site [active] 523794002249 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 523794002250 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 523794002251 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794002252 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523794002253 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 523794002254 active site 523794002255 metal binding site [ion binding]; metal-binding site 523794002256 YARHG domain; Region: YARHG; pfam13308 523794002257 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 523794002258 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 523794002259 nucleotide binding site [chemical binding]; other site 523794002260 putative NEF/HSP70 interaction site [polypeptide binding]; other site 523794002261 SBD interface [polypeptide binding]; other site 523794002262 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 523794002263 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 523794002264 NAD(P) binding pocket [chemical binding]; other site 523794002265 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 523794002266 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 523794002267 ligand binding site [chemical binding]; other site 523794002268 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 523794002269 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523794002270 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523794002271 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 523794002272 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 523794002273 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 523794002274 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 523794002275 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 523794002276 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 523794002277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794002278 ATP binding site [chemical binding]; other site 523794002279 putative Mg++ binding site [ion binding]; other site 523794002280 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 523794002281 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 523794002282 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 523794002283 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 523794002284 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 523794002285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 523794002286 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 523794002287 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 523794002288 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 523794002289 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 523794002290 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 523794002291 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 523794002292 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 523794002293 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 523794002294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794002295 motif II; other site 523794002296 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 523794002297 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 523794002298 NAD binding site [chemical binding]; other site 523794002299 HIRAN domain; Region: HIRAN; pfam08797 523794002300 5'-3' exonuclease; Region: 53EXOc; smart00475 523794002301 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 523794002302 active site 523794002303 metal binding site 1 [ion binding]; metal-binding site 523794002304 putative 5' ssDNA interaction site; other site 523794002305 metal binding site 3; metal-binding site 523794002306 metal binding site 2 [ion binding]; metal-binding site 523794002307 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 523794002308 putative DNA binding site [nucleotide binding]; other site 523794002309 putative metal binding site [ion binding]; other site 523794002310 DNA polymerase I; Provisional; Region: PRK05755 523794002311 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 523794002312 active site 523794002313 DNA binding site [nucleotide binding] 523794002314 catalytic site [active] 523794002315 AzlC protein; Region: AzlC; cl00570 523794002316 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 523794002317 metal binding sites [ion binding]; metal-binding site 523794002318 dimer interface [polypeptide binding]; other site 523794002319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794002320 dimer interface [polypeptide binding]; other site 523794002321 conserved gate region; other site 523794002322 putative PBP binding loops; other site 523794002323 ABC-ATPase subunit interface; other site 523794002324 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794002325 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794002326 Walker A/P-loop; other site 523794002327 ATP binding site [chemical binding]; other site 523794002328 Q-loop/lid; other site 523794002329 ABC transporter signature motif; other site 523794002330 Walker B; other site 523794002331 D-loop; other site 523794002332 H-loop/switch region; other site 523794002333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794002334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794002335 substrate binding pocket [chemical binding]; other site 523794002336 membrane-bound complex binding site; other site 523794002337 hinge residues; other site 523794002338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794002339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794002340 substrate binding pocket [chemical binding]; other site 523794002341 membrane-bound complex binding site; other site 523794002342 hinge residues; other site 523794002343 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794002344 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794002345 ligand binding site [chemical binding]; other site 523794002346 Domain of unknown function DUF20; Region: UPF0118; pfam01594 523794002347 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 523794002348 Outer membrane efflux protein; Region: OEP; pfam02321 523794002349 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 523794002350 HlyD family secretion protein; Region: HlyD_3; pfam13437 523794002351 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523794002352 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523794002353 Walker A/P-loop; other site 523794002354 ATP binding site [chemical binding]; other site 523794002355 Q-loop/lid; other site 523794002356 ABC transporter signature motif; other site 523794002357 Walker B; other site 523794002358 D-loop; other site 523794002359 H-loop/switch region; other site 523794002360 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523794002361 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 523794002362 FtsX-like permease family; Region: FtsX; pfam02687 523794002363 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 523794002364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 523794002365 dimer interface [polypeptide binding]; other site 523794002366 active site 523794002367 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523794002368 catalytic residues [active] 523794002369 substrate binding site [chemical binding]; other site 523794002370 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 523794002371 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794002372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794002373 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 523794002374 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 523794002375 substrate binding site [chemical binding]; other site 523794002376 active site 523794002377 catalytic residues [active] 523794002378 heterodimer interface [polypeptide binding]; other site 523794002379 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 523794002380 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 523794002381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794002382 catalytic residue [active] 523794002383 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 523794002384 active site 523794002385 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 523794002386 active site 523794002387 ribulose/triose binding site [chemical binding]; other site 523794002388 phosphate binding site [ion binding]; other site 523794002389 substrate (anthranilate) binding pocket [chemical binding]; other site 523794002390 product (indole) binding pocket [chemical binding]; other site 523794002391 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 523794002392 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 523794002393 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 523794002394 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 523794002395 glutamine binding [chemical binding]; other site 523794002396 catalytic triad [active] 523794002397 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 523794002398 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 523794002399 anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820 523794002400 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 523794002401 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 523794002402 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 523794002403 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 523794002404 active site 523794002405 P-loop; other site 523794002406 phosphorylation site [posttranslational modification] 523794002407 Initiator Replication protein; Region: Rep_3; pfam01051 523794002408 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 523794002409 methionine cluster; other site 523794002410 active site 523794002411 phosphorylation site [posttranslational modification] 523794002412 metal binding site [ion binding]; metal-binding site 523794002413 putative oxidoreductase; Provisional; Region: PRK10206 523794002414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 523794002415 maltose O-acetyltransferase; Provisional; Region: PRK10092 523794002416 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 523794002417 active site 523794002418 substrate binding site [chemical binding]; other site 523794002419 trimer interface [polypeptide binding]; other site 523794002420 CoA binding site [chemical binding]; other site 523794002421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 523794002422 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523794002423 metal-binding site [ion binding] 523794002424 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523794002425 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523794002426 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 523794002427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 523794002428 non-specific DNA binding site [nucleotide binding]; other site 523794002429 salt bridge; other site 523794002430 sequence-specific DNA binding site [nucleotide binding]; other site 523794002431 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 523794002432 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 523794002433 TPP-binding site; other site 523794002434 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523794002435 PYR/PP interface [polypeptide binding]; other site 523794002436 dimer interface [polypeptide binding]; other site 523794002437 TPP binding site [chemical binding]; other site 523794002438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523794002439 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 523794002440 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 523794002441 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 523794002442 aspartate kinase; Reviewed; Region: PRK06635 523794002443 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 523794002444 putative catalytic residues [active] 523794002445 putative nucleotide binding site [chemical binding]; other site 523794002446 putative aspartate binding site [chemical binding]; other site 523794002447 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 523794002448 putative allosteric regulatory site; other site 523794002449 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 523794002450 putative allosteric regulatory residue; other site 523794002451 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 523794002452 oligomerisation interface [polypeptide binding]; other site 523794002453 mobile loop; other site 523794002454 roof hairpin; other site 523794002455 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 523794002456 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 523794002457 ring oligomerisation interface [polypeptide binding]; other site 523794002458 ATP/Mg binding site [chemical binding]; other site 523794002459 stacking interactions; other site 523794002460 hinge regions; other site 523794002461 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 523794002462 homodimer interface [polypeptide binding]; other site 523794002463 catalytic residues [active] 523794002464 NAD binding site [chemical binding]; other site 523794002465 substrate binding pocket [chemical binding]; other site 523794002466 flexible flap; other site 523794002467 maltose O-acetyltransferase; Provisional; Region: PRK10092 523794002468 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 523794002469 active site 523794002470 substrate binding site [chemical binding]; other site 523794002471 trimer interface [polypeptide binding]; other site 523794002472 CoA binding site [chemical binding]; other site 523794002473 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 523794002474 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 523794002475 dimer interface [polypeptide binding]; other site 523794002476 active site 523794002477 rod shape-determining protein MreC; Provisional; Region: PRK13922 523794002478 rod shape-determining protein MreC; Region: MreC; pfam04085 523794002479 Recombination protein O N terminal; Region: RecO_N; pfam11967 523794002480 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523794002481 active site 523794002482 phosphorylation site [posttranslational modification] 523794002483 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 523794002484 ATP cone domain; Region: ATP-cone; pfam03477 523794002485 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 523794002486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 523794002487 FtsX-like permease family; Region: FtsX; pfam02687 523794002488 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 523794002489 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 523794002490 Walker A/P-loop; other site 523794002491 ATP binding site [chemical binding]; other site 523794002492 Q-loop/lid; other site 523794002493 ABC transporter signature motif; other site 523794002494 Walker B; other site 523794002495 D-loop; other site 523794002496 H-loop/switch region; other site 523794002497 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 523794002498 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 523794002499 active site 523794002500 DNA binding site [nucleotide binding] 523794002501 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 523794002502 active site 523794002503 catalytic motif [active] 523794002504 Zn binding site [ion binding]; other site 523794002505 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794002506 Src Homology 3 domain superfamily; Region: SH3; cd00174 523794002507 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794002508 Bacterial SH3 domain; Region: SH3_3; cl17532 523794002509 Bacterial SH3 domain; Region: SH3_3; cl17532 523794002510 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794002511 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 523794002512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794002513 Walker A/P-loop; other site 523794002514 ATP binding site [chemical binding]; other site 523794002515 Q-loop/lid; other site 523794002516 ABC transporter signature motif; other site 523794002517 Walker B; other site 523794002518 D-loop; other site 523794002519 H-loop/switch region; other site 523794002520 ABC transporter; Region: ABC_tran_2; pfam12848 523794002521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 523794002522 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 523794002523 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 523794002524 active site 523794002525 dimer interface [polypeptide binding]; other site 523794002526 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 523794002527 dimer interface [polypeptide binding]; other site 523794002528 ADP-ribose binding site [chemical binding]; other site 523794002529 active site 523794002530 nudix motif; other site 523794002531 metal binding site [ion binding]; metal-binding site 523794002532 6-phosphofructokinase; Provisional; Region: PRK03202 523794002533 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 523794002534 active site 523794002535 ADP/pyrophosphate binding site [chemical binding]; other site 523794002536 dimerization interface [polypeptide binding]; other site 523794002537 allosteric effector site; other site 523794002538 fructose-1,6-bisphosphate binding site; other site 523794002539 pyruvate kinase; Provisional; Region: PRK09206 523794002540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 523794002541 domain interfaces; other site 523794002542 active site 523794002543 recombination protein RecR; Reviewed; Region: recR; PRK00076 523794002544 RecR protein; Region: RecR; pfam02132 523794002545 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 523794002546 putative active site [active] 523794002547 putative metal-binding site [ion binding]; other site 523794002548 tetramer interface [polypeptide binding]; other site 523794002549 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 523794002550 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 523794002551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794002552 catalytic residue [active] 523794002553 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 523794002554 Protein of unknown function (DUF342); Region: DUF342; pfam03961 523794002555 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 523794002556 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 523794002557 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523794002558 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 523794002559 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523794002560 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 523794002561 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 523794002562 IHF - DNA interface [nucleotide binding]; other site 523794002563 IHF dimer interface [polypeptide binding]; other site 523794002564 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 523794002565 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 523794002566 zinc binding site [ion binding]; other site 523794002567 putative ligand binding site [chemical binding]; other site 523794002568 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 523794002569 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 523794002570 zinc binding site [ion binding]; other site 523794002571 putative ligand binding site [chemical binding]; other site 523794002572 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 523794002573 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 523794002574 TM-ABC transporter signature motif; other site 523794002575 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 523794002576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794002577 Walker A/P-loop; other site 523794002578 ATP binding site [chemical binding]; other site 523794002579 Q-loop/lid; other site 523794002580 ABC transporter signature motif; other site 523794002581 Walker B; other site 523794002582 D-loop; other site 523794002583 H-loop/switch region; other site 523794002584 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794002585 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794002586 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 523794002587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794002588 binding surface 523794002589 TPR motif; other site 523794002590 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794002591 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 523794002592 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 523794002593 Protein kinase domain; Region: Pkinase; pfam00069 523794002594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523794002595 active site 523794002596 ATP binding site [chemical binding]; other site 523794002597 substrate binding site [chemical binding]; other site 523794002598 activation loop (A-loop); other site 523794002599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 523794002600 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 523794002601 protein-splicing catalytic site; other site 523794002602 thioester formation/cholesterol transfer; other site 523794002603 Pretoxin HINT domain; Region: PT-HINT; pfam07591 523794002604 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 523794002605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 523794002606 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 523794002607 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 523794002608 active site 523794002609 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 523794002610 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794002611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794002612 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794002613 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523794002614 phosphopeptide binding site; other site 523794002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794002616 TPR motif; other site 523794002617 binding surface 523794002618 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 523794002619 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 523794002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002621 TPR motif; other site 523794002622 binding surface 523794002623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794002624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002625 TPR motif; other site 523794002626 binding surface 523794002627 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523794002628 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794002629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002630 TPR motif; other site 523794002631 binding surface 523794002632 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794002633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002634 binding surface 523794002635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523794002636 TPR motif; other site 523794002637 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 523794002638 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 523794002639 phosphopeptide binding site; other site 523794002640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523794002641 HSP70 interaction site [polypeptide binding]; other site 523794002642 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794002643 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 523794002644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794002645 S-adenosylmethionine binding site [chemical binding]; other site 523794002646 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 523794002647 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 523794002648 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523794002649 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 523794002650 helicase superfamily c-terminal domain; Region: HELICc; smart00490 523794002651 nucleotide binding region [chemical binding]; other site 523794002652 ATP-binding site [chemical binding]; other site 523794002653 DNA topoisomerase III; Provisional; Region: PRK07726 523794002654 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 523794002655 active site 523794002656 putative interdomain interaction site [polypeptide binding]; other site 523794002657 putative metal-binding site [ion binding]; other site 523794002658 putative nucleotide binding site [chemical binding]; other site 523794002659 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 523794002660 domain I; other site 523794002661 DNA binding groove [nucleotide binding] 523794002662 phosphate binding site [ion binding]; other site 523794002663 domain II; other site 523794002664 domain III; other site 523794002665 nucleotide binding site [chemical binding]; other site 523794002666 catalytic site [active] 523794002667 domain IV; other site 523794002668 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 523794002669 NlpC/P60 family; Region: NLPC_P60; pfam00877 523794002670 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 523794002671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 523794002672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 523794002673 catalytic residue [active] 523794002674 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 523794002675 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 523794002676 phosphodiesterase; Provisional; Region: PRK12704 523794002677 Conjugal transfer protein TraD; Region: TraD; cl05753 523794002678 Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959 523794002679 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 523794002680 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 523794002681 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 523794002682 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 523794002683 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 523794002684 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523794002685 Walker A motif; other site 523794002686 ATP binding site [chemical binding]; other site 523794002687 Walker B motif; other site 523794002688 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 523794002689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523794002690 Walker A motif; other site 523794002691 ATP binding site [chemical binding]; other site 523794002692 Walker B motif; other site 523794002693 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 523794002694 Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504 523794002695 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 523794002696 VirB7 interaction site; other site 523794002697 VirB8 protein; Region: VirB8; cl01500 523794002698 MobA/MobL family; Region: MobA_MobL; pfam03389 523794002699 Fic family protein [Function unknown]; Region: COG3177 523794002700 Fic/DOC family; Region: Fic; pfam02661 523794002701 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523794002702 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 523794002703 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 523794002704 PhoU domain; Region: PhoU; pfam01895 523794002705 PhoU domain; Region: PhoU; pfam01895 523794002706 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 523794002707 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 523794002708 putative ligand binding site [chemical binding]; other site 523794002709 putative NAD binding site [chemical binding]; other site 523794002710 catalytic site [active] 523794002711 peptide chain release factor 2; Provisional; Region: PRK05589 523794002712 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523794002713 RF-1 domain; Region: RF-1; pfam00472 523794002714 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 523794002715 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 523794002716 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 523794002717 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 523794002718 metal binding site [ion binding]; metal-binding site 523794002719 dimer interface [polypeptide binding]; other site 523794002720 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 523794002721 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 523794002722 putative active site [active] 523794002723 putative metal binding site [ion binding]; other site 523794002724 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 523794002725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 523794002726 phosphopeptide binding site; other site 523794002727 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 523794002728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794002729 FeS/SAM binding site; other site 523794002730 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 523794002731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794002732 Walker A motif; other site 523794002733 ATP binding site [chemical binding]; other site 523794002734 Walker B motif; other site 523794002735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523794002736 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 523794002737 active site 523794002738 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 523794002739 Catalytic domain of Protein Kinases; Region: PKc; cd00180 523794002740 active site 523794002741 ATP binding site [chemical binding]; other site 523794002742 substrate binding site [chemical binding]; other site 523794002743 activation loop (A-loop); other site 523794002744 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 523794002745 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 523794002746 23S rRNA interface [nucleotide binding]; other site 523794002747 L3 interface [polypeptide binding]; other site 523794002748 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 523794002749 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 523794002750 HTH domain; Region: HTH_11; pfam08279 523794002751 PRD domain; Region: PRD; pfam00874 523794002752 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 523794002753 active site 523794002754 P-loop; other site 523794002755 phosphorylation site [posttranslational modification] 523794002756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523794002757 active site 523794002758 phosphorylation site [posttranslational modification] 523794002759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523794002760 active site 523794002761 phosphorylation site [posttranslational modification] 523794002762 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 523794002763 active site 523794002764 P-loop; other site 523794002765 phosphorylation site [posttranslational modification] 523794002766 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 523794002767 transketolase; Reviewed; Region: PRK05899 523794002768 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 523794002769 TPP-binding site [chemical binding]; other site 523794002770 dimer interface [polypeptide binding]; other site 523794002771 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 523794002772 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523794002773 PYR/PP interface [polypeptide binding]; other site 523794002774 dimer interface [polypeptide binding]; other site 523794002775 TPP binding site [chemical binding]; other site 523794002776 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523794002777 Predicted membrane protein [Function unknown]; Region: COG2323 523794002778 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 523794002779 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523794002780 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 523794002781 Peptidase family U32; Region: Peptidase_U32; pfam01136 523794002782 Collagenase; Region: DUF3656; pfam12392 523794002783 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 523794002784 O-Antigen ligase; Region: Wzy_C; pfam04932 523794002785 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 523794002786 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 523794002787 active pocket/dimerization site; other site 523794002788 active site 523794002789 phosphorylation site [posttranslational modification] 523794002790 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 523794002791 RimM N-terminal domain; Region: RimM; pfam01782 523794002792 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 523794002793 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 523794002794 YARHG domain; Region: YARHG; pfam13308 523794002795 Predicted transcriptional regulators [Transcription]; Region: COG1695 523794002796 CAAX protease self-immunity; Region: Abi; pfam02517 523794002797 SnoaL-like domain; Region: SnoaL_3; pfam13474 523794002798 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 523794002799 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 523794002800 active site 523794002801 HIGH motif; other site 523794002802 dimer interface [polypeptide binding]; other site 523794002803 KMSKS motif; other site 523794002804 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 523794002805 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 523794002806 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 523794002807 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 523794002808 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 523794002809 nucleotide binding site [chemical binding]; other site 523794002810 putative NEF/HSP70 interaction site [polypeptide binding]; other site 523794002811 SBD interface [polypeptide binding]; other site 523794002812 DKNYY family; Region: DKNYY; pfam13644 523794002813 DKNYY family; Region: DKNYY; pfam13644 523794002814 DKNYY family; Region: DKNYY; pfam13644 523794002815 DKNYY family; Region: DKNYY; pfam13644 523794002816 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 523794002817 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 523794002818 catalytic residues [active] 523794002819 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794002820 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 523794002821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523794002822 nucleotide binding site [chemical binding]; other site 523794002823 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794002824 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794002825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794002826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794002827 dimerization interface [polypeptide binding]; other site 523794002828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794002829 dimer interface [polypeptide binding]; other site 523794002830 phosphorylation site [posttranslational modification] 523794002831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794002832 ATP binding site [chemical binding]; other site 523794002833 Mg2+ binding site [ion binding]; other site 523794002834 G-X-G motif; other site 523794002835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794002836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794002837 active site 523794002838 phosphorylation site [posttranslational modification] 523794002839 intermolecular recognition site; other site 523794002840 dimerization interface [polypeptide binding]; other site 523794002841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794002842 DNA binding site [nucleotide binding] 523794002843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523794002844 DNA-binding site [nucleotide binding]; DNA binding site 523794002845 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 523794002846 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 523794002847 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 523794002848 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 523794002849 ligand binding site [chemical binding]; other site 523794002850 NAD binding site [chemical binding]; other site 523794002851 dimerization interface [polypeptide binding]; other site 523794002852 catalytic site [active] 523794002853 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 523794002854 putative L-serine binding site [chemical binding]; other site 523794002855 homoserine kinase; Provisional; Region: PRK01212 523794002856 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523794002857 Uncharacterized conserved protein [Function unknown]; Region: COG3339 523794002858 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 523794002859 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794002860 RNA binding surface [nucleotide binding]; other site 523794002861 oligoendopeptidase F; Region: pepF; TIGR00181 523794002862 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 523794002863 active site 523794002864 Zn binding site [ion binding]; other site 523794002865 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 523794002866 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794002867 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794002868 ligand binding site [chemical binding]; other site 523794002869 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 523794002870 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523794002871 putative active site [active] 523794002872 catalytic site [active] 523794002873 Putative serine esterase (DUF676); Region: DUF676; pfam05057 523794002874 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523794002875 nucleotide binding site [chemical binding]; other site 523794002876 Type III pantothenate kinase; Region: Pan_kinase; cl17198 523794002877 OPT oligopeptide transporter protein; Region: OPT; cl14607 523794002878 OPT oligopeptide transporter protein; Region: OPT; cl14607 523794002879 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 523794002880 metal binding site 2 [ion binding]; metal-binding site 523794002881 putative DNA binding helix; other site 523794002882 metal binding site 1 [ion binding]; metal-binding site 523794002883 dimer interface [polypeptide binding]; other site 523794002884 structural Zn2+ binding site [ion binding]; other site 523794002885 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 523794002886 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 523794002887 intersubunit interface [polypeptide binding]; other site 523794002888 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523794002889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794002890 Walker A/P-loop; other site 523794002891 ATP binding site [chemical binding]; other site 523794002892 Q-loop/lid; other site 523794002893 ABC transporter signature motif; other site 523794002894 Walker B; other site 523794002895 D-loop; other site 523794002896 H-loop/switch region; other site 523794002897 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 523794002898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 523794002899 ABC-ATPase subunit interface; other site 523794002900 dimer interface [polypeptide binding]; other site 523794002901 AAA domain; Region: AAA_21; pfam13304 523794002902 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 523794002903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794002904 Radical SAM superfamily; Region: Radical_SAM; pfam04055 523794002905 FeS/SAM binding site; other site 523794002906 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 523794002907 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 523794002908 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 523794002909 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 523794002910 CRISPR-associated protein; Region: TIGR03986 523794002911 RAMP superfamily; Region: RAMPs; pfam03787 523794002912 Protein of unknown function (DUF328); Region: DUF328; pfam03883 523794002913 Predicted ATPase [General function prediction only]; Region: COG4637 523794002914 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794002915 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 523794002916 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 523794002917 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 523794002918 EcsC protein family; Region: EcsC; pfam12787 523794002919 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 523794002920 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 523794002921 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 523794002922 G1 box; other site 523794002923 GTP/Mg2+ binding site [chemical binding]; other site 523794002924 G2 box; other site 523794002925 Switch I region; other site 523794002926 G3 box; other site 523794002927 Switch II region; other site 523794002928 G4 box; other site 523794002929 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 523794002930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794002931 FeS/SAM binding site; other site 523794002932 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 523794002933 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 523794002934 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794002935 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 523794002936 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 523794002937 dimer interface [polypeptide binding]; other site 523794002938 putative radical transfer pathway; other site 523794002939 diiron center [ion binding]; other site 523794002940 tyrosyl radical; other site 523794002941 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 523794002942 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 523794002943 Class I ribonucleotide reductase; Region: RNR_I; cd01679 523794002944 active site 523794002945 dimer interface [polypeptide binding]; other site 523794002946 catalytic residues [active] 523794002947 effector binding site; other site 523794002948 R2 peptide binding site; other site 523794002949 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 523794002950 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794002951 catalytic residues [active] 523794002952 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 523794002953 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 523794002954 putative dimer interface [polypeptide binding]; other site 523794002955 putative anticodon binding site; other site 523794002956 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 523794002957 homodimer interface [polypeptide binding]; other site 523794002958 motif 1; other site 523794002959 motif 2; other site 523794002960 active site 523794002961 motif 3; other site 523794002962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794002963 binding surface 523794002964 TPR motif; other site 523794002965 DNA protecting protein DprA; Region: dprA; TIGR00732 523794002966 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 523794002967 DNA topoisomerase I; Validated; Region: PRK06599 523794002968 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 523794002969 active site 523794002970 interdomain interaction site; other site 523794002971 putative metal-binding site [ion binding]; other site 523794002972 nucleotide binding site [chemical binding]; other site 523794002973 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 523794002974 domain I; other site 523794002975 DNA binding groove [nucleotide binding] 523794002976 phosphate binding site [ion binding]; other site 523794002977 domain II; other site 523794002978 domain III; other site 523794002979 nucleotide binding site [chemical binding]; other site 523794002980 catalytic site [active] 523794002981 domain IV; other site 523794002982 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 523794002983 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 523794002984 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523794002985 active site 523794002986 DNA binding site [nucleotide binding] 523794002987 Int/Topo IB signature motif; other site 523794002988 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 523794002989 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 523794002990 GTP/Mg2+ binding site [chemical binding]; other site 523794002991 G4 box; other site 523794002992 G5 box; other site 523794002993 G1 box; other site 523794002994 Switch I region; other site 523794002995 G2 box; other site 523794002996 G3 box; other site 523794002997 Switch II region; other site 523794002998 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 523794002999 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_2; cd10034 523794003000 putative uracil binding site [chemical binding]; other site 523794003001 putative active site [active] 523794003002 GTP-binding protein YchF; Reviewed; Region: PRK09601 523794003003 YchF GTPase; Region: YchF; cd01900 523794003004 G1 box; other site 523794003005 GTP/Mg2+ binding site [chemical binding]; other site 523794003006 Switch I region; other site 523794003007 G2 box; other site 523794003008 Switch II region; other site 523794003009 G3 box; other site 523794003010 G4 box; other site 523794003011 G5 box; other site 523794003012 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 523794003013 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 523794003014 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 523794003015 Ion channel; Region: Ion_trans_2; pfam07885 523794003016 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 523794003017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523794003018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523794003019 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523794003020 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 523794003021 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 523794003022 ATP-binding site [chemical binding]; other site 523794003023 Sugar specificity; other site 523794003024 Pyrimidine base specificity; other site 523794003025 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 523794003026 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 523794003027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523794003028 NAD(P) binding site [chemical binding]; other site 523794003029 active site 523794003030 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 523794003031 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 523794003032 Protein of unknown function (DUF464); Region: DUF464; pfam04327 523794003033 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 523794003034 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 523794003035 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 523794003036 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 523794003037 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 523794003038 FAD binding pocket [chemical binding]; other site 523794003039 FAD binding motif [chemical binding]; other site 523794003040 phosphate binding motif [ion binding]; other site 523794003041 beta-alpha-beta structure motif; other site 523794003042 NAD binding pocket [chemical binding]; other site 523794003043 Iron coordination center [ion binding]; other site 523794003044 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 523794003045 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 523794003046 4Fe-4S binding domain; Region: Fer4; pfam00037 523794003047 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 523794003048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523794003049 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523794003050 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 523794003051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 523794003052 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 523794003053 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 523794003054 amidase catalytic site [active] 523794003055 Zn binding residues [ion binding]; other site 523794003056 substrate binding site [chemical binding]; other site 523794003057 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 523794003058 aspartate aminotransferase; Provisional; Region: PRK07568 523794003059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794003060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794003061 homodimer interface [polypeptide binding]; other site 523794003062 catalytic residue [active] 523794003063 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 523794003064 putative methyltransferase; Provisional; Region: PRK11524 523794003065 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 523794003066 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 523794003067 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 523794003068 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 523794003069 malate dehydrogenase; Provisional; Region: PRK13529 523794003070 Malic enzyme, N-terminal domain; Region: malic; pfam00390 523794003071 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 523794003072 NAD(P) binding pocket [chemical binding]; other site 523794003073 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 523794003074 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 523794003075 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 523794003076 Ligand Binding Site [chemical binding]; other site 523794003077 Predicted permeases [General function prediction only]; Region: COG0679 523794003078 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 523794003079 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794003080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794003081 substrate binding pocket [chemical binding]; other site 523794003082 membrane-bound complex binding site; other site 523794003083 hinge residues; other site 523794003084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794003085 dimer interface [polypeptide binding]; other site 523794003086 conserved gate region; other site 523794003087 putative PBP binding loops; other site 523794003088 ABC-ATPase subunit interface; other site 523794003089 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794003090 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794003091 Walker A/P-loop; other site 523794003092 ATP binding site [chemical binding]; other site 523794003093 Q-loop/lid; other site 523794003094 ABC transporter signature motif; other site 523794003095 Walker B; other site 523794003096 D-loop; other site 523794003097 H-loop/switch region; other site 523794003098 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 523794003099 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 523794003100 Walker A/P-loop; other site 523794003101 ATP binding site [chemical binding]; other site 523794003102 Q-loop/lid; other site 523794003103 ABC transporter signature motif; other site 523794003104 Walker B; other site 523794003105 D-loop; other site 523794003106 H-loop/switch region; other site 523794003107 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 523794003108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794003109 ABC-ATPase subunit interface; other site 523794003110 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 523794003111 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 523794003112 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 523794003113 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 523794003114 active site 523794003115 Zn binding site [ion binding]; other site 523794003116 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 523794003117 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 523794003118 nucleotide binding pocket [chemical binding]; other site 523794003119 K-X-D-G motif; other site 523794003120 catalytic site [active] 523794003121 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 523794003122 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 523794003123 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 523794003124 Dimer interface [polypeptide binding]; other site 523794003125 Photosystem II protein; Region: PSII; cl08223 523794003126 HEAT repeats; Region: HEAT_2; pfam13646 523794003127 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 523794003128 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 523794003129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794003130 FeS/SAM binding site; other site 523794003131 Transglycosylase; Region: Transgly; pfam00912 523794003132 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 523794003133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 523794003134 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 523794003135 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 523794003136 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 523794003137 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 523794003138 Domain of unknown function DUF21; Region: DUF21; pfam01595 523794003139 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 523794003140 Transporter associated domain; Region: CorC_HlyC; pfam03471 523794003141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523794003142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794003143 Coenzyme A binding pocket [chemical binding]; other site 523794003144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 523794003145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794003146 Coenzyme A binding pocket [chemical binding]; other site 523794003147 argininosuccinate lyase; Provisional; Region: PRK00855 523794003148 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 523794003149 active sites [active] 523794003150 tetramer interface [polypeptide binding]; other site 523794003151 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 523794003152 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 523794003153 active site 523794003154 tetramer interface; other site 523794003155 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 523794003156 G1 box; other site 523794003157 GTP/Mg2+ binding site [chemical binding]; other site 523794003158 G2 box; other site 523794003159 Switch I region; other site 523794003160 G3 box; other site 523794003161 Switch II region; other site 523794003162 G4 box; other site 523794003163 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 523794003164 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 523794003165 regulatory protein interface [polypeptide binding]; other site 523794003166 regulatory phosphorylation site [posttranslational modification]; other site 523794003167 YARHG domain; Region: YARHG; pfam13308 523794003168 Haemolytic domain; Region: Haemolytic; pfam01809 523794003169 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 523794003170 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 523794003171 nucleotide binding site [chemical binding]; other site 523794003172 SulA interaction site; other site 523794003173 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 523794003174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 523794003175 Putative esterase; Region: Esterase; pfam00756 523794003176 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523794003177 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523794003178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794003179 Walker A/P-loop; other site 523794003180 ATP binding site [chemical binding]; other site 523794003181 Q-loop/lid; other site 523794003182 ABC transporter signature motif; other site 523794003183 Walker B; other site 523794003184 D-loop; other site 523794003185 H-loop/switch region; other site 523794003186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523794003187 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523794003188 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 523794003189 Walker A/P-loop; other site 523794003190 ATP binding site [chemical binding]; other site 523794003191 Q-loop/lid; other site 523794003192 ABC transporter signature motif; other site 523794003193 Walker B; other site 523794003194 D-loop; other site 523794003195 H-loop/switch region; other site 523794003196 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 523794003197 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 523794003198 Uncharacterized conserved protein [Function unknown]; Region: COG1434 523794003199 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 523794003200 putative active site [active] 523794003201 GTP-binding protein LepA; Provisional; Region: PRK05433 523794003202 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 523794003203 G1 box; other site 523794003204 putative GEF interaction site [polypeptide binding]; other site 523794003205 GTP/Mg2+ binding site [chemical binding]; other site 523794003206 Switch I region; other site 523794003207 G2 box; other site 523794003208 G3 box; other site 523794003209 Switch II region; other site 523794003210 G4 box; other site 523794003211 G5 box; other site 523794003212 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 523794003213 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 523794003214 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 523794003215 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 523794003216 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 523794003217 active site 523794003218 catalytic site [active] 523794003219 substrate binding site [chemical binding]; other site 523794003220 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 523794003221 PLD-like domain; Region: PLDc_2; pfam13091 523794003222 putative active site [active] 523794003223 catalytic site [active] 523794003224 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523794003225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794003226 ATP binding site [chemical binding]; other site 523794003227 putative Mg++ binding site [ion binding]; other site 523794003228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794003229 nucleotide binding region [chemical binding]; other site 523794003230 ATP-binding site [chemical binding]; other site 523794003231 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 523794003232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 523794003233 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 523794003234 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 523794003235 Int/Topo IB signature motif; other site 523794003236 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 523794003237 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 523794003238 ScpA/B protein; Region: ScpA_ScpB; cl00598 523794003239 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 523794003240 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 523794003241 active site 523794003242 Riboflavin kinase; Region: Flavokinase; pfam01687 523794003243 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 523794003244 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 523794003245 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 523794003246 putative substrate binding site [chemical binding]; other site 523794003247 putative ATP binding site [chemical binding]; other site 523794003248 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 523794003249 histidinol-phosphatase; Reviewed; Region: PRK08123 523794003250 active site 523794003251 dimer interface [polypeptide binding]; other site 523794003252 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 523794003253 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 523794003254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 523794003255 metal binding site [ion binding]; metal-binding site 523794003256 Protein of unknown function DUF86; Region: DUF86; cl01031 523794003257 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 523794003258 active site 523794003259 NTP binding site [chemical binding]; other site 523794003260 metal binding triad [ion binding]; metal-binding site 523794003261 antibiotic binding site [chemical binding]; other site 523794003262 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 523794003263 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 523794003264 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 523794003265 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 523794003266 substrate binding site [chemical binding]; other site 523794003267 glutamase interaction surface [polypeptide binding]; other site 523794003268 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 523794003269 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 523794003270 catalytic residues [active] 523794003271 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794003272 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794003273 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794003274 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 523794003275 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 523794003276 putative active site [active] 523794003277 oxyanion strand; other site 523794003278 catalytic triad [active] 523794003279 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 523794003280 PLD-like domain; Region: PLDc_2; pfam13091 523794003281 homodimer interface [polypeptide binding]; other site 523794003282 putative active site [active] 523794003283 catalytic site [active] 523794003284 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 523794003285 putative active site pocket [active] 523794003286 4-fold oligomerization interface [polypeptide binding]; other site 523794003287 metal binding residues [ion binding]; metal-binding site 523794003288 3-fold/trimer interface [polypeptide binding]; other site 523794003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794003290 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 523794003291 Walker A motif; other site 523794003292 ATP binding site [chemical binding]; other site 523794003293 Walker B motif; other site 523794003294 arginine finger; other site 523794003295 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 523794003296 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 523794003297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794003298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794003299 homodimer interface [polypeptide binding]; other site 523794003300 catalytic residue [active] 523794003301 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 523794003302 AAA domain; Region: AAA_14; pfam13173 523794003303 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 523794003304 histidinol dehydrogenase; Region: hisD; TIGR00069 523794003305 NAD binding site [chemical binding]; other site 523794003306 dimerization interface [polypeptide binding]; other site 523794003307 product binding site; other site 523794003308 substrate binding site [chemical binding]; other site 523794003309 zinc binding site [ion binding]; other site 523794003310 catalytic residues [active] 523794003311 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 523794003312 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 523794003313 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 523794003314 dimer interface [polypeptide binding]; other site 523794003315 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 523794003316 motif 1; other site 523794003317 active site 523794003318 motif 2; other site 523794003319 motif 3; other site 523794003320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 523794003321 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 523794003322 nudix motif; other site 523794003323 dihydropteroate synthase; Region: DHPS; TIGR01496 523794003324 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 523794003325 substrate binding pocket [chemical binding]; other site 523794003326 dimer interface [polypeptide binding]; other site 523794003327 inhibitor binding site; inhibition site 523794003328 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 523794003329 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794003330 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794003331 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 523794003332 GTP cyclohydrolase I; Provisional; Region: PLN03044 523794003333 active site 523794003334 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 523794003335 catalytic center binding site [active] 523794003336 ATP binding site [chemical binding]; other site 523794003337 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 523794003338 active site 523794003339 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 523794003340 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 523794003341 putative ATP binding site [chemical binding]; other site 523794003342 putative substrate interface [chemical binding]; other site 523794003343 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 523794003344 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 523794003345 FMN binding site [chemical binding]; other site 523794003346 active site 523794003347 catalytic residues [active] 523794003348 substrate binding site [chemical binding]; other site 523794003349 Peptidase family M48; Region: Peptidase_M48; cl12018 523794003350 Peptidase family M48; Region: Peptidase_M48; cl12018 523794003351 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 523794003352 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 523794003353 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 523794003354 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 523794003355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794003356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794003357 DNA binding site [nucleotide binding] 523794003358 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 523794003359 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 523794003360 Walker A motif; other site 523794003361 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 523794003362 homoserine O-succinyltransferase; Provisional; Region: PRK05368 523794003363 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 523794003364 proposed active site lysine [active] 523794003365 conserved cys residue [active] 523794003366 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 523794003367 DNA polymerase III subunit beta; Validated; Region: PRK05643 523794003368 putative DNA binding surface [nucleotide binding]; other site 523794003369 dimer interface [polypeptide binding]; other site 523794003370 beta-clamp/clamp loader binding surface; other site 523794003371 beta-clamp/translesion DNA polymerase binding surface; other site 523794003372 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 523794003373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523794003374 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 523794003375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523794003376 DNA binding residues [nucleotide binding] 523794003377 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 523794003378 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 523794003379 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 523794003380 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 523794003381 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794003382 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 523794003383 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 523794003384 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 523794003385 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 523794003386 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 523794003387 active site 523794003388 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 523794003389 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 523794003390 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 523794003391 Predicted transcriptional regulator [Transcription]; Region: COG2378 523794003392 HTH domain; Region: HTH_11; pfam08279 523794003393 WYL domain; Region: WYL; pfam13280 523794003394 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 523794003395 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 523794003396 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523794003397 active site 523794003398 HIGH motif; other site 523794003399 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 523794003400 active site 523794003401 KMSKS motif; other site 523794003402 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 523794003403 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 523794003404 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 523794003405 dimer interface [polypeptide binding]; other site 523794003406 FMN binding site [chemical binding]; other site 523794003407 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 523794003408 dimer interface [polypeptide binding]; other site 523794003409 FMN binding site [chemical binding]; other site 523794003410 endonuclease IV; Provisional; Region: PRK01060 523794003411 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 523794003412 AP (apurinic/apyrimidinic) site pocket; other site 523794003413 DNA interaction; other site 523794003414 Metal-binding active site; metal-binding site 523794003415 TfoX N-terminal domain; Region: TfoX_N; pfam04993 523794003416 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 523794003417 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 523794003418 DKNYY family; Region: DKNYY; pfam13644 523794003419 DKNYY family; Region: DKNYY; pfam13644 523794003420 DKNYY family; Region: DKNYY; pfam13644 523794003421 DKNYY family; Region: DKNYY; pfam13644 523794003422 DKNYY family; Region: DKNYY; pfam13644 523794003423 DKNYY family; Region: DKNYY; pfam13644 523794003424 DKNYY family; Region: DKNYY; pfam13644 523794003425 DKNYY family; Region: DKNYY; pfam13644 523794003426 DKNYY family; Region: DKNYY; pfam13644 523794003427 DKNYY family; Region: DKNYY; pfam13644 523794003428 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 523794003429 nucleotide binding site/active site [active] 523794003430 HIT family signature motif; other site 523794003431 catalytic residue [active] 523794003432 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 523794003433 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 523794003434 active site 523794003435 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 523794003436 KH domain; Region: KH_4; pfam13083 523794003437 G-X-X-G motif; other site 523794003438 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 523794003439 Ligand Binding Site [chemical binding]; other site 523794003440 CCR4-Not complex component, Not1; Region: Not1; pfam04054 523794003441 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 523794003442 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 523794003443 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 523794003444 S-adenosylmethionine binding site [chemical binding]; other site 523794003445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794003446 active site 523794003447 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 523794003448 23S rRNA binding site [nucleotide binding]; other site 523794003449 L21 binding site [polypeptide binding]; other site 523794003450 L13 binding site [polypeptide binding]; other site 523794003451 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 523794003452 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 523794003453 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 523794003454 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 523794003455 Transposase; Region: HTH_Tnp_IS630; pfam01710 523794003456 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 523794003457 DDE superfamily endonuclease; Region: DDE_3; pfam13358 523794003458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 523794003459 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 523794003460 Found in ATP-dependent protease La (LON); Region: LON; smart00464 523794003461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794003462 Walker A motif; other site 523794003463 ATP binding site [chemical binding]; other site 523794003464 Walker B motif; other site 523794003465 arginine finger; other site 523794003466 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 523794003467 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 523794003468 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 523794003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794003470 Walker A motif; other site 523794003471 ATP binding site [chemical binding]; other site 523794003472 Walker B motif; other site 523794003473 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 523794003474 Clp protease; Region: CLP_protease; pfam00574 523794003475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 523794003476 oligomer interface [polypeptide binding]; other site 523794003477 active site residues [active] 523794003478 trigger factor; Region: tig; TIGR00115 523794003479 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 523794003480 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 523794003481 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 523794003482 DHH family; Region: DHH; pfam01368 523794003483 DHHA1 domain; Region: DHHA1; pfam02272 523794003484 Ribosome-binding factor A [Translation, ribosomal structure and biogenesis]; Region: RbfA; COG0858 523794003485 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 523794003486 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 523794003487 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 523794003488 G1 box; other site 523794003489 putative GEF interaction site [polypeptide binding]; other site 523794003490 GTP/Mg2+ binding site [chemical binding]; other site 523794003491 Switch I region; other site 523794003492 G2 box; other site 523794003493 G3 box; other site 523794003494 Switch II region; other site 523794003495 G4 box; other site 523794003496 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 523794003497 Translation-initiation factor 2; Region: IF-2; pfam11987 523794003498 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 523794003499 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 523794003500 putative RNA binding cleft [nucleotide binding]; other site 523794003501 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 523794003502 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 523794003503 NusA N-terminal domain; Region: NusA_N; pfam08529 523794003504 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 523794003505 RNA binding site [nucleotide binding]; other site 523794003506 homodimer interface [polypeptide binding]; other site 523794003507 NusA-like KH domain; Region: KH_5; pfam13184 523794003508 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 523794003509 G-X-X-G motif; other site 523794003510 ribosome maturation protein RimP; Reviewed; Region: PRK00092 523794003511 Sm and related proteins; Region: Sm_like; cl00259 523794003512 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 523794003513 putative oligomer interface [polypeptide binding]; other site 523794003514 putative RNA binding site [nucleotide binding]; other site 523794003515 Chromate transporter; Region: Chromate_transp; pfam02417 523794003516 Chromate transporter; Region: Chromate_transp; pfam02417 523794003517 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794003518 Sel1 repeat; Region: Sel1; cl02723 523794003519 Sel1-like repeats; Region: SEL1; smart00671 523794003520 Sel1 repeat; Region: Sel1; cl02723 523794003521 Sel1-like repeats; Region: SEL1; smart00671 523794003522 TPR repeat; Region: TPR_11; pfam13414 523794003523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794003524 binding surface 523794003525 TPR motif; other site 523794003526 TPR repeat; Region: TPR_11; pfam13414 523794003527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794003528 binding surface 523794003529 TPR motif; other site 523794003530 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 523794003531 Ligand Binding Site [chemical binding]; other site 523794003532 TIGR00269 family protein; Region: TIGR00269 523794003533 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 523794003534 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 523794003535 Ca binding site [ion binding]; other site 523794003536 active site 523794003537 catalytic site [active] 523794003538 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 523794003539 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 523794003540 putative MPT binding site; other site 523794003541 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 523794003542 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 523794003543 nucleotide binding site [chemical binding]; other site 523794003544 TraX protein; Region: TraX; pfam05857 523794003545 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 523794003546 CAAX protease self-immunity; Region: Abi; pfam02517 523794003547 Predicted membrane protein [Function unknown]; Region: COG3212 523794003548 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794003549 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794003550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794003551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794003552 dimerization interface [polypeptide binding]; other site 523794003553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794003554 dimer interface [polypeptide binding]; other site 523794003555 phosphorylation site [posttranslational modification] 523794003556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794003557 ATP binding site [chemical binding]; other site 523794003558 Mg2+ binding site [ion binding]; other site 523794003559 G-X-G motif; other site 523794003560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794003561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794003562 active site 523794003563 phosphorylation site [posttranslational modification] 523794003564 intermolecular recognition site; other site 523794003565 dimerization interface [polypeptide binding]; other site 523794003566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794003567 DNA binding site [nucleotide binding] 523794003568 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 523794003569 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 523794003570 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 523794003571 active site 523794003572 metal binding site [ion binding]; metal-binding site 523794003573 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 523794003574 dihydrodipicolinate synthase; Region: dapA; TIGR00674 523794003575 dimer interface [polypeptide binding]; other site 523794003576 active site 523794003577 catalytic residue [active] 523794003578 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 523794003579 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 523794003580 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 523794003581 aspartate kinase; Reviewed; Region: PRK06635 523794003582 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 523794003583 putative nucleotide binding site [chemical binding]; other site 523794003584 putative catalytic residues [active] 523794003585 putative Mg ion binding site [ion binding]; other site 523794003586 putative aspartate binding site [chemical binding]; other site 523794003587 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 523794003588 putative allosteric regulatory site; other site 523794003589 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 523794003590 putative allosteric regulatory residue; other site 523794003591 diaminopimelate decarboxylase; Region: lysA; TIGR01048 523794003592 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 523794003593 active site 523794003594 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523794003595 substrate binding site [chemical binding]; other site 523794003596 catalytic residues [active] 523794003597 dimer interface [polypeptide binding]; other site 523794003598 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 523794003599 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 523794003600 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794003601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794003602 Probable transposase; Region: OrfB_IS605; pfam01385 523794003603 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 523794003604 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 523794003605 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 523794003606 metal ion-dependent adhesion site (MIDAS); other site 523794003607 MoxR-like ATPases [General function prediction only]; Region: COG0714 523794003608 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 523794003609 SWIM zinc finger; Region: SWIM; pfam04434 523794003610 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 523794003611 HPr interaction site; other site 523794003612 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523794003613 active site 523794003614 phosphorylation site [posttranslational modification] 523794003615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794003616 binding surface 523794003617 TPR motif; other site 523794003618 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 523794003619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794003620 binding surface 523794003621 TPR motif; other site 523794003622 ribonuclease PH; Reviewed; Region: rph; PRK00173 523794003623 Ribonuclease PH; Region: RNase_PH_bact; cd11362 523794003624 hexamer interface [polypeptide binding]; other site 523794003625 active site 523794003626 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 523794003627 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 523794003628 dimer interface [polypeptide binding]; other site 523794003629 active site 523794003630 glycine-pyridoxal phosphate binding site [chemical binding]; other site 523794003631 folate binding site [chemical binding]; other site 523794003632 VacJ like lipoprotein; Region: VacJ; cl01073 523794003633 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 523794003634 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523794003635 Walker A/P-loop; other site 523794003636 ATP binding site [chemical binding]; other site 523794003637 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 523794003638 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 523794003639 ABC transporter signature motif; other site 523794003640 Walker B; other site 523794003641 D-loop; other site 523794003642 H-loop/switch region; other site 523794003643 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 523794003644 Bacterial sugar transferase; Region: Bac_transf; pfam02397 523794003645 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794003646 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 523794003647 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 523794003648 Acyltransferase family; Region: Acyl_transf_3; pfam01757 523794003649 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 523794003650 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 523794003651 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 523794003652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523794003653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523794003654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794003655 Walker A/P-loop; other site 523794003656 ATP binding site [chemical binding]; other site 523794003657 Q-loop/lid; other site 523794003658 ABC transporter signature motif; other site 523794003659 Walker B; other site 523794003660 D-loop; other site 523794003661 H-loop/switch region; other site 523794003662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523794003663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523794003664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794003665 Walker A/P-loop; other site 523794003666 ATP binding site [chemical binding]; other site 523794003667 Q-loop/lid; other site 523794003668 ABC transporter signature motif; other site 523794003669 Walker B; other site 523794003670 D-loop; other site 523794003671 H-loop/switch region; other site 523794003672 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 523794003673 amino acid carrier protein; Region: agcS; TIGR00835 523794003674 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 523794003675 dimer interface [polypeptide binding]; other site 523794003676 catalytic triad [active] 523794003677 peroxidatic and resolving cysteines [active] 523794003678 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 523794003679 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 523794003680 active site 523794003681 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 523794003682 Part of AAA domain; Region: AAA_19; pfam13245 523794003683 Family description; Region: UvrD_C_2; pfam13538 523794003684 thymidine kinase; Provisional; Region: PRK04296 523794003685 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523794003686 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 523794003687 homodimer interface [polypeptide binding]; other site 523794003688 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 523794003689 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 523794003690 active site 523794003691 catalytic site [active] 523794003692 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 523794003693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794003694 active site 523794003695 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 523794003696 hypothetical protein; Reviewed; Region: PRK12497 523794003697 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 523794003698 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 523794003699 RNA/DNA hybrid binding site [nucleotide binding]; other site 523794003700 active site 523794003701 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523794003702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794003703 RNA binding surface [nucleotide binding]; other site 523794003704 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523794003705 active site 523794003706 Fic/DOC family; Region: Fic; pfam02661 523794003707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 523794003708 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 523794003709 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 523794003710 active site 523794003711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 523794003712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794003713 motif II; other site 523794003714 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 523794003715 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 523794003716 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 523794003717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523794003718 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 523794003719 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 523794003720 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794003721 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794003722 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794003723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794003724 binding surface 523794003725 TPR motif; other site 523794003726 Pleckstrin homology-like domain; Region: PH-like; cl17171 523794003727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 523794003728 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523794003729 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 523794003730 tetramer interface [polypeptide binding]; other site 523794003731 catalytic Zn binding site [ion binding]; other site 523794003732 NADP binding site [chemical binding]; other site 523794003733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523794003734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523794003735 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 523794003736 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 523794003737 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 523794003738 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523794003739 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 523794003740 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523794003741 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 523794003742 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 523794003743 substrate binding pocket [chemical binding]; other site 523794003744 catalytic triad [active] 523794003745 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 523794003746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523794003747 catalytic site [active] 523794003748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523794003749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523794003750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 523794003751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 523794003752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523794003753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 523794003754 active site 523794003755 catalytic tetrad [active] 523794003756 chaperone protein DnaJ; Provisional; Region: PRK14276 523794003757 aminotransferase A; Validated; Region: PRK07683 523794003758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794003760 homodimer interface [polypeptide binding]; other site 523794003761 catalytic residue [active] 523794003762 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 523794003763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794003764 S-adenosylmethionine binding site [chemical binding]; other site 523794003765 citrate synthase; Provisional; Region: PRK14032 523794003766 Citrate synthase; Region: Citrate_synt; pfam00285 523794003767 oxalacetate binding site [chemical binding]; other site 523794003768 citrylCoA binding site [chemical binding]; other site 523794003769 coenzyme A binding site [chemical binding]; other site 523794003770 catalytic triad [active] 523794003771 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 523794003772 tartrate dehydrogenase; Region: TTC; TIGR02089 523794003773 aconitate hydratase; Validated; Region: PRK07229 523794003774 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 523794003775 substrate binding site [chemical binding]; other site 523794003776 ligand binding site [chemical binding]; other site 523794003777 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 523794003778 substrate binding site [chemical binding]; other site 523794003779 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 523794003780 active site 523794003781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794003782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794003783 active site 523794003784 phosphorylation site [posttranslational modification] 523794003785 intermolecular recognition site; other site 523794003786 dimerization interface [polypeptide binding]; other site 523794003787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794003788 DNA binding site [nucleotide binding] 523794003789 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 523794003790 dimerization interface [polypeptide binding]; other site 523794003791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794003792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794003793 dimer interface [polypeptide binding]; other site 523794003794 phosphorylation site [posttranslational modification] 523794003795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794003796 ATP binding site [chemical binding]; other site 523794003797 Mg2+ binding site [ion binding]; other site 523794003798 G-X-G motif; other site 523794003799 BioY family; Region: BioY; pfam02632 523794003800 biotin synthase; Region: bioB; TIGR00433 523794003801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794003802 FeS/SAM binding site; other site 523794003803 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 523794003804 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 523794003805 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 523794003806 protein binding site [polypeptide binding]; other site 523794003807 YGGT family; Region: YGGT; pfam02325 523794003808 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 523794003809 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 523794003810 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 523794003811 RNase E interface [polypeptide binding]; other site 523794003812 trimer interface [polypeptide binding]; other site 523794003813 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 523794003814 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 523794003815 RNase E interface [polypeptide binding]; other site 523794003816 trimer interface [polypeptide binding]; other site 523794003817 active site 523794003818 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 523794003819 putative nucleic acid binding region [nucleotide binding]; other site 523794003820 G-X-X-G motif; other site 523794003821 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 523794003822 RNA binding site [nucleotide binding]; other site 523794003823 domain interface; other site 523794003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794003825 ABC-ATPase subunit interface; other site 523794003826 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 523794003827 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 523794003828 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 523794003829 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794003830 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 523794003831 Walker A/P-loop; other site 523794003832 ATP binding site [chemical binding]; other site 523794003833 Q-loop/lid; other site 523794003834 ABC transporter signature motif; other site 523794003835 Walker B; other site 523794003836 D-loop; other site 523794003837 H-loop/switch region; other site 523794003838 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 523794003839 MarR family; Region: MarR; pfam01047 523794003840 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 523794003841 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 523794003842 putative NAD(P) binding site [chemical binding]; other site 523794003843 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 523794003844 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 523794003845 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 523794003846 substrate binding pocket [chemical binding]; other site 523794003847 dimer interface [polypeptide binding]; other site 523794003848 inhibitor binding site; inhibition site 523794003849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 523794003850 B12 binding site [chemical binding]; other site 523794003851 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 523794003852 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 523794003853 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794003854 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794003855 ligand binding site [chemical binding]; other site 523794003856 seryl-tRNA synthetase; Provisional; Region: PRK05431 523794003857 Adhesion protein FadA; Region: FadA; pfam09403 523794003858 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 523794003859 active site 523794003860 phosphorylation site [posttranslational modification] 523794003861 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 523794003862 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 523794003863 GTPase CgtA; Reviewed; Region: obgE; PRK12297 523794003864 GTP1/OBG; Region: GTP1_OBG; pfam01018 523794003865 Obg GTPase; Region: Obg; cd01898 523794003866 G1 box; other site 523794003867 GTP/Mg2+ binding site [chemical binding]; other site 523794003868 Switch I region; other site 523794003869 G2 box; other site 523794003870 G3 box; other site 523794003871 Switch II region; other site 523794003872 G4 box; other site 523794003873 G5 box; other site 523794003874 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 523794003875 Staphylococcal nuclease homologues; Region: SNc; smart00318 523794003876 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 523794003877 Catalytic site; other site 523794003878 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 523794003879 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 523794003880 homodimer interface [polypeptide binding]; other site 523794003881 substrate-cofactor binding pocket; other site 523794003882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794003883 catalytic residue [active] 523794003884 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523794003885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794003886 Coenzyme A binding pocket [chemical binding]; other site 523794003887 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 523794003888 ligand binding site [chemical binding]; other site 523794003889 active site 523794003890 UGI interface [polypeptide binding]; other site 523794003891 catalytic site [active] 523794003892 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 523794003893 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523794003894 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523794003895 Walker A/P-loop; other site 523794003896 ATP binding site [chemical binding]; other site 523794003897 Q-loop/lid; other site 523794003898 ABC transporter signature motif; other site 523794003899 Walker B; other site 523794003900 D-loop; other site 523794003901 H-loop/switch region; other site 523794003902 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 523794003903 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 523794003904 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 523794003905 Walker A/P-loop; other site 523794003906 ATP binding site [chemical binding]; other site 523794003907 Q-loop/lid; other site 523794003908 ABC transporter signature motif; other site 523794003909 Walker B; other site 523794003910 D-loop; other site 523794003911 H-loop/switch region; other site 523794003912 hypothetical protein; Provisional; Region: PRK13661 523794003913 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 523794003914 catalytic motif [active] 523794003915 Zn binding site [ion binding]; other site 523794003916 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 523794003917 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 523794003918 generic binding surface II; other site 523794003919 generic binding surface I; other site 523794003920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794003921 S-adenosylmethionine binding site [chemical binding]; other site 523794003922 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794003923 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 523794003924 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 523794003925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 523794003926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523794003927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 523794003928 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 523794003929 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523794003930 active site turn [active] 523794003931 phosphorylation site [posttranslational modification] 523794003932 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523794003933 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 523794003934 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 523794003935 substrate binding [chemical binding]; other site 523794003936 active site 523794003937 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 523794003938 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 523794003939 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 523794003940 Walker A/P-loop; other site 523794003941 ATP binding site [chemical binding]; other site 523794003942 Q-loop/lid; other site 523794003943 ABC transporter signature motif; other site 523794003944 Walker B; other site 523794003945 D-loop; other site 523794003946 H-loop/switch region; other site 523794003947 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 523794003948 Melibiase; Region: Melibiase; pfam02065 523794003949 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 523794003950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794003951 dimer interface [polypeptide binding]; other site 523794003952 conserved gate region; other site 523794003953 putative PBP binding loops; other site 523794003954 ABC-ATPase subunit interface; other site 523794003955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794003956 dimer interface [polypeptide binding]; other site 523794003957 conserved gate region; other site 523794003958 putative PBP binding loops; other site 523794003959 ABC-ATPase subunit interface; other site 523794003960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 523794003961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 523794003962 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 523794003963 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 523794003964 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 523794003965 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 523794003966 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 523794003967 galactokinase; Provisional; Region: PRK05322 523794003968 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 523794003969 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523794003970 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523794003971 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 523794003972 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 523794003973 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 523794003974 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 523794003975 DNA repair protein RadA; Provisional; Region: PRK11823 523794003976 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523794003977 Walker A motif; other site 523794003978 ATP binding site [chemical binding]; other site 523794003979 Walker B motif; other site 523794003980 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 523794003981 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 523794003982 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 523794003983 active site 523794003984 (T/H)XGH motif; other site 523794003985 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 523794003986 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 523794003987 dimerization interface [polypeptide binding]; other site 523794003988 active site 523794003989 metal binding site [ion binding]; metal-binding site 523794003990 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 523794003991 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 523794003992 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 523794003993 dimer interface [polypeptide binding]; other site 523794003994 active site 523794003995 acyl carrier protein; Provisional; Region: acpP; PRK00982 523794003996 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 523794003997 predicted active site [active] 523794003998 catalytic triad [active] 523794003999 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 523794004000 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 523794004001 phosphate binding site [ion binding]; other site 523794004002 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 523794004003 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 523794004004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794004005 ATP binding site [chemical binding]; other site 523794004006 putative Mg++ binding site [ion binding]; other site 523794004007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794004008 nucleotide binding region [chemical binding]; other site 523794004009 ATP-binding site [chemical binding]; other site 523794004010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794004011 Coenzyme A binding pocket [chemical binding]; other site 523794004012 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523794004013 Catalytic site [active] 523794004014 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 523794004015 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 523794004016 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 523794004017 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 523794004018 purine monophosphate binding site [chemical binding]; other site 523794004019 dimer interface [polypeptide binding]; other site 523794004020 putative catalytic residues [active] 523794004021 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 523794004022 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 523794004023 recombination factor protein RarA; Reviewed; Region: PRK13342 523794004024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794004025 Walker A motif; other site 523794004026 ATP binding site [chemical binding]; other site 523794004027 Walker B motif; other site 523794004028 arginine finger; other site 523794004029 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 523794004030 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 523794004031 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 523794004032 DNA binding site [nucleotide binding] 523794004033 active site 523794004034 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 523794004035 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 523794004036 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 523794004037 Ca binding site [ion binding]; other site 523794004038 active site 523794004039 catalytic site [active] 523794004040 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 523794004041 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 523794004042 NAD binding site [chemical binding]; other site 523794004043 sugar binding site [chemical binding]; other site 523794004044 divalent metal binding site [ion binding]; other site 523794004045 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 523794004046 dimer interface [polypeptide binding]; other site 523794004047 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 523794004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 523794004049 DNA-binding site [nucleotide binding]; DNA binding site 523794004050 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 523794004051 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 523794004052 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523794004053 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523794004054 active site turn [active] 523794004055 phosphorylation site [posttranslational modification] 523794004056 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 523794004057 putative catalytic site [active] 523794004058 putative metal binding site [ion binding]; other site 523794004059 putative phosphate binding site [ion binding]; other site 523794004060 4-alpha-glucanotransferase; Provisional; Region: PRK14508 523794004061 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 523794004062 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 523794004063 active site 523794004064 substrate binding site [chemical binding]; other site 523794004065 cosubstrate binding site; other site 523794004066 catalytic site [active] 523794004067 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 523794004068 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 523794004069 dimerization interface [polypeptide binding]; other site 523794004070 putative ATP binding site [chemical binding]; other site 523794004071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 523794004072 amidophosphoribosyltransferase; Provisional; Region: PRK07272 523794004073 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 523794004074 active site 523794004075 tetramer interface [polypeptide binding]; other site 523794004076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794004077 active site 523794004078 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 523794004079 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 523794004080 ATP binding site [chemical binding]; other site 523794004081 active site 523794004082 substrate binding site [chemical binding]; other site 523794004083 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 523794004084 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 523794004085 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 523794004086 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 523794004087 dimerization interface [polypeptide binding]; other site 523794004088 ATP binding site [chemical binding]; other site 523794004089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 523794004090 dimerization interface [polypeptide binding]; other site 523794004091 ATP binding site [chemical binding]; other site 523794004092 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 523794004093 conserved cys residue [active] 523794004094 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 523794004095 ArsC family; Region: ArsC; pfam03960 523794004096 putative ArsC-like catalytic residues; other site 523794004097 putative TRX-like catalytic residues [active] 523794004098 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 523794004099 active site 523794004100 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 523794004101 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 523794004102 tandem repeat interface [polypeptide binding]; other site 523794004103 oligomer interface [polypeptide binding]; other site 523794004104 active site residues [active] 523794004105 excinuclease ABC subunit B; Provisional; Region: PRK05298 523794004106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794004107 ATP binding site [chemical binding]; other site 523794004108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794004109 nucleotide binding region [chemical binding]; other site 523794004110 ATP-binding site [chemical binding]; other site 523794004111 Ultra-violet resistance protein B; Region: UvrB; pfam12344 523794004112 GTPase Era; Reviewed; Region: era; PRK00089 523794004113 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 523794004114 G1 box; other site 523794004115 GTP/Mg2+ binding site [chemical binding]; other site 523794004116 Switch I region; other site 523794004117 G2 box; other site 523794004118 Switch II region; other site 523794004119 G3 box; other site 523794004120 G4 box; other site 523794004121 G5 box; other site 523794004122 KH domain; Region: KH_2; pfam07650 523794004123 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 523794004124 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 523794004125 PhnA protein; Region: PhnA; pfam03831 523794004126 Competence protein; Region: Competence; pfam03772 523794004127 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 523794004128 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 523794004129 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 523794004130 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 523794004131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794004132 binding surface 523794004133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004134 TPR motif; other site 523794004135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794004138 binding surface 523794004139 TPR motif; other site 523794004140 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004141 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 523794004142 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 523794004143 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 523794004144 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 523794004145 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 523794004146 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 523794004147 dimer interface [polypeptide binding]; other site 523794004148 active site 523794004149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523794004150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523794004151 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523794004152 dimerization interface [polypeptide binding]; other site 523794004153 asparagine synthetase AsnA; Provisional; Region: PRK05425 523794004154 motif 1; other site 523794004155 dimer interface [polypeptide binding]; other site 523794004156 active site 523794004157 motif 2; other site 523794004158 motif 3; other site 523794004159 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 523794004160 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 523794004161 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 523794004162 dimerization interface [polypeptide binding]; other site 523794004163 active site 523794004164 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 523794004165 Lumazine binding domain; Region: Lum_binding; pfam00677 523794004166 Lumazine binding domain; Region: Lum_binding; pfam00677 523794004167 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 523794004168 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 523794004169 catalytic motif [active] 523794004170 Zn binding site [ion binding]; other site 523794004171 RibD C-terminal domain; Region: RibD_C; cl17279 523794004172 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 523794004173 homopentamer interface [polypeptide binding]; other site 523794004174 active site 523794004175 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 523794004176 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 523794004177 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 523794004178 metal binding site [ion binding]; metal-binding site 523794004179 dimer interface [polypeptide binding]; other site 523794004180 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 523794004181 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 523794004182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004183 S-adenosylmethionine binding site [chemical binding]; other site 523794004184 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 523794004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 523794004186 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 523794004187 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 523794004188 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 523794004189 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 523794004190 pyrroline-5-carboxylate reductase; Region: PLN02688 523794004191 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 523794004192 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 523794004193 substrate binding site [chemical binding]; other site 523794004194 dimer interface [polypeptide binding]; other site 523794004195 ATP binding site [chemical binding]; other site 523794004196 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 523794004197 active site 523794004198 tetramer interface [polypeptide binding]; other site 523794004199 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523794004200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523794004201 DNA binding site [nucleotide binding] 523794004202 domain linker motif; other site 523794004203 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 523794004204 dimerization interface [polypeptide binding]; other site 523794004205 ligand binding site [chemical binding]; other site 523794004206 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794004207 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794004208 ligand binding site [chemical binding]; other site 523794004209 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 523794004210 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 523794004211 putative active site [active] 523794004212 putative FMN binding site [chemical binding]; other site 523794004213 putative substrate binding site [chemical binding]; other site 523794004214 putative catalytic residue [active] 523794004215 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 523794004216 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794004217 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 523794004218 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 523794004219 FMN binding site [chemical binding]; other site 523794004220 active site 523794004221 catalytic residues [active] 523794004222 substrate binding site [chemical binding]; other site 523794004223 Domain of unknown function (DUF386); Region: DUF386; cl01047 523794004224 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 523794004225 dimer interface [polypeptide binding]; other site 523794004226 catalytic triad [active] 523794004227 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 523794004228 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 523794004229 active site 523794004230 dimer interface [polypeptide binding]; other site 523794004231 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 523794004232 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 523794004233 catalytic triad [active] 523794004234 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 523794004235 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 523794004236 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 523794004237 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 523794004238 TPR repeat; Region: TPR_11; pfam13414 523794004239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794004240 TPR motif; other site 523794004241 binding surface 523794004242 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 523794004243 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 523794004244 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 523794004245 YARHG domain; Region: YARHG; pfam13308 523794004246 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 523794004247 YARHG domain; Region: YARHG; pfam13308 523794004248 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 523794004249 elongation factor P; Validated; Region: PRK00529 523794004250 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 523794004251 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 523794004252 RNA binding site [nucleotide binding]; other site 523794004253 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 523794004254 RNA binding site [nucleotide binding]; other site 523794004255 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 523794004256 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 523794004257 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 523794004258 ATP binding site [chemical binding]; other site 523794004259 Mg++ binding site [ion binding]; other site 523794004260 motif III; other site 523794004261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794004262 nucleotide binding region [chemical binding]; other site 523794004263 ATP-binding site [chemical binding]; other site 523794004264 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 523794004265 RNA binding site [nucleotide binding]; other site 523794004266 Predicted membrane protein [Function unknown]; Region: COG3212 523794004267 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794004268 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794004269 Predicted membrane protein [Function unknown]; Region: COG3212 523794004270 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794004271 Predicted membrane protein [Function unknown]; Region: COG3212 523794004272 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 523794004273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794004274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794004275 active site 523794004276 phosphorylation site [posttranslational modification] 523794004277 intermolecular recognition site; other site 523794004278 dimerization interface [polypeptide binding]; other site 523794004279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794004280 DNA binding site [nucleotide binding] 523794004281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794004282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794004283 dimerization interface [polypeptide binding]; other site 523794004284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794004285 dimer interface [polypeptide binding]; other site 523794004286 phosphorylation site [posttranslational modification] 523794004287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794004288 ATP binding site [chemical binding]; other site 523794004289 Mg2+ binding site [ion binding]; other site 523794004290 G-X-G motif; other site 523794004291 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 523794004292 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 523794004293 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 523794004294 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 523794004295 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 523794004296 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 523794004297 catalytic site [active] 523794004298 subunit interface [polypeptide binding]; other site 523794004299 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 523794004300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523794004301 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523794004302 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 523794004303 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523794004304 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523794004305 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 523794004306 IMP binding site; other site 523794004307 dimer interface [polypeptide binding]; other site 523794004308 interdomain contacts; other site 523794004309 partial ornithine binding site; other site 523794004310 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 523794004311 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 523794004312 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 523794004313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 523794004314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 523794004315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523794004316 active site 523794004317 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 523794004318 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 523794004319 conserved hypothetical protein; Region: TIGR02328 523794004320 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 523794004321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794004322 catalytic core [active] 523794004323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794004324 Coenzyme A binding pocket [chemical binding]; other site 523794004325 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 523794004326 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 523794004327 Walker A/P-loop; other site 523794004328 ATP binding site [chemical binding]; other site 523794004329 Q-loop/lid; other site 523794004330 ABC transporter signature motif; other site 523794004331 Walker B; other site 523794004332 D-loop; other site 523794004333 H-loop/switch region; other site 523794004334 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 523794004335 NMT1/THI5 like; Region: NMT1; pfam09084 523794004336 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 523794004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794004338 dimer interface [polypeptide binding]; other site 523794004339 conserved gate region; other site 523794004340 putative PBP binding loops; other site 523794004341 ABC-ATPase subunit interface; other site 523794004342 Domain of unknown function DUF77; Region: DUF77; pfam01910 523794004343 histidinol-phosphatase; Provisional; Region: PRK07328 523794004344 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 523794004345 active site 523794004346 dimer interface [polypeptide binding]; other site 523794004347 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 523794004348 DNA-binding site [nucleotide binding]; DNA binding site 523794004349 RNA-binding motif; other site 523794004350 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 523794004351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 523794004352 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 523794004353 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 523794004354 Bacterial SH3 domain; Region: SH3_3; cl17532 523794004355 Tannase and feruloyl esterase; Region: Tannase; pfam07519 523794004356 DKNYY family; Region: DKNYY; pfam13644 523794004357 DKNYY family; Region: DKNYY; pfam13644 523794004358 DKNYY family; Region: DKNYY; pfam13644 523794004359 DKNYY family; Region: DKNYY; pfam13644 523794004360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 523794004361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 523794004362 active site 523794004363 catalytic tetrad [active] 523794004364 Uncharacterized conserved protein [Function unknown]; Region: COG1359 523794004365 Uncharacterized conserved protein [Function unknown]; Region: COG1359 523794004366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 523794004367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 523794004368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 523794004369 dimerization interface [polypeptide binding]; other site 523794004370 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 523794004371 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523794004372 DKNYY family; Region: DKNYY; pfam13644 523794004373 DKNYY family; Region: DKNYY; pfam13644 523794004374 DKNYY family; Region: DKNYY; pfam13644 523794004375 DKNYY family; Region: DKNYY; pfam13644 523794004376 DKNYY family; Region: DKNYY; pfam13644 523794004377 DKNYY family; Region: DKNYY; pfam13644 523794004378 DKNYY family; Region: DKNYY; pfam13644 523794004379 DKNYY family; Region: DKNYY; pfam13644 523794004380 DKNYY family; Region: DKNYY; pfam13644 523794004381 DKNYY family; Region: DKNYY; pfam13644 523794004382 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 523794004383 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 523794004384 nucleotide binding site [chemical binding]; other site 523794004385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523794004386 HSP70 interaction site [polypeptide binding]; other site 523794004387 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 523794004388 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 523794004389 tetramer interface [polypeptide binding]; other site 523794004390 active site 523794004391 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523794004392 active site residue [active] 523794004393 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 523794004394 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 523794004395 GDP-binding site [chemical binding]; other site 523794004396 ACT binding site; other site 523794004397 IMP binding site; other site 523794004398 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 523794004399 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794004400 motif II; other site 523794004401 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 523794004402 hexamer interface [polypeptide binding]; other site 523794004403 RNA binding site [nucleotide binding]; other site 523794004404 Histidine-zinc binding site [chemical binding]; other site 523794004405 Dehydroquinase class II; Region: DHquinase_II; pfam01220 523794004406 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 523794004407 trimer interface [polypeptide binding]; other site 523794004408 active site 523794004409 dimer interface [polypeptide binding]; other site 523794004410 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 523794004411 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 523794004412 ADP binding site [chemical binding]; other site 523794004413 magnesium binding site [ion binding]; other site 523794004414 putative shikimate binding site; other site 523794004415 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 523794004416 CHD5-like protein; Region: CHD5; pfam04420 523794004417 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 523794004418 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 523794004419 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 523794004420 shikimate binding site; other site 523794004421 NAD(P) binding site [chemical binding]; other site 523794004422 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 523794004423 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 523794004424 active site 523794004425 uracil binding [chemical binding]; other site 523794004426 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 523794004427 Chorismate mutase type II; Region: CM_2; pfam01817 523794004428 Prephenate dehydratase; Region: PDT; pfam00800 523794004429 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 523794004430 putative L-Phe binding site [chemical binding]; other site 523794004431 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794004432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794004433 Probable transposase; Region: OrfB_IS605; pfam01385 523794004434 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 523794004435 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 523794004436 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 523794004437 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 523794004438 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 523794004439 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 523794004440 homotetramer interface [polypeptide binding]; other site 523794004441 FMN binding site [chemical binding]; other site 523794004442 homodimer contacts [polypeptide binding]; other site 523794004443 putative active site [active] 523794004444 putative substrate binding site [chemical binding]; other site 523794004445 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 523794004446 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 523794004447 ribosome recycling factor; Reviewed; Region: frr; PRK00083 523794004448 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 523794004449 hinge region; other site 523794004450 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 523794004451 putative nucleotide binding site [chemical binding]; other site 523794004452 uridine monophosphate binding site [chemical binding]; other site 523794004453 homohexameric interface [polypeptide binding]; other site 523794004454 elongation factor Ts; Provisional; Region: tsf; PRK09377 523794004455 UBA/TS-N domain; Region: UBA; pfam00627 523794004456 Elongation factor TS; Region: EF_TS; pfam00889 523794004457 Elongation factor TS; Region: EF_TS; pfam00889 523794004458 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 523794004459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 523794004460 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 523794004461 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 523794004462 rRNA interaction site [nucleotide binding]; other site 523794004463 S8 interaction site; other site 523794004464 putative laminin-1 binding site; other site 523794004465 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 523794004466 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 523794004467 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 523794004468 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 523794004469 active site 523794004470 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 523794004471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523794004472 NAD(P) binding site [chemical binding]; other site 523794004473 active site 523794004474 peptidase T; Region: peptidase-T; TIGR01882 523794004475 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 523794004476 metal binding site [ion binding]; metal-binding site 523794004477 dimer interface [polypeptide binding]; other site 523794004478 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 523794004479 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 523794004480 TM2 domain; Region: TM2; pfam05154 523794004481 DKNYY family; Region: DKNYY; pfam13644 523794004482 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 523794004483 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 523794004484 active site 523794004485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523794004486 dimer interface [polypeptide binding]; other site 523794004487 substrate binding site [chemical binding]; other site 523794004488 catalytic residues [active] 523794004489 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 523794004490 active site 523794004491 dimerization interface [polypeptide binding]; other site 523794004492 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 523794004493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 523794004494 putative acyl-acceptor binding pocket; other site 523794004495 RecX family; Region: RecX; pfam02631 523794004496 recombinase A; Provisional; Region: recA; PRK09354 523794004497 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 523794004498 hexamer interface [polypeptide binding]; other site 523794004499 Walker A motif; other site 523794004500 ATP binding site [chemical binding]; other site 523794004501 Walker B motif; other site 523794004502 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 523794004503 thymidylate kinase; Provisional; Region: PRK13975; cl17243 523794004504 ketol-acid reductoisomerase; Provisional; Region: PRK05479 523794004505 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 523794004506 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 523794004507 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 523794004508 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 523794004509 active site 523794004510 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523794004511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004512 S-adenosylmethionine binding site [chemical binding]; other site 523794004513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 523794004514 EamA-like transporter family; Region: EamA; pfam00892 523794004515 EamA-like transporter family; Region: EamA; pfam00892 523794004516 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523794004517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794004518 Walker A/P-loop; other site 523794004519 ATP binding site [chemical binding]; other site 523794004520 Q-loop/lid; other site 523794004521 ABC transporter signature motif; other site 523794004522 Walker B; other site 523794004523 D-loop; other site 523794004524 H-loop/switch region; other site 523794004525 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 523794004526 tartrate dehydrogenase; Provisional; Region: PRK08194 523794004527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 523794004528 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 523794004529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523794004530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523794004531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 523794004532 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 523794004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 523794004534 Walker A/P-loop; other site 523794004535 ATP binding site [chemical binding]; other site 523794004536 Q-loop/lid; other site 523794004537 ABC transporter signature motif; other site 523794004538 Walker B; other site 523794004539 D-loop; other site 523794004540 H-loop/switch region; other site 523794004541 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 523794004542 tartrate dehydrogenase; Provisional; Region: PRK08194 523794004543 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 523794004544 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794004545 ligand binding site [chemical binding]; other site 523794004546 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 523794004547 ligand binding site [chemical binding]; other site 523794004548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 523794004549 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 523794004550 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 523794004551 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 523794004552 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 523794004553 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 523794004554 substrate binding site [chemical binding]; other site 523794004555 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 523794004556 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 523794004557 substrate binding site [chemical binding]; other site 523794004558 ligand binding site [chemical binding]; other site 523794004559 Fic family protein [Function unknown]; Region: COG3177 523794004560 Fic/DOC family; Region: Fic; pfam02661 523794004561 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 523794004562 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 523794004563 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 523794004564 dimer interface [polypeptide binding]; other site 523794004565 active site 523794004566 CoA binding pocket [chemical binding]; other site 523794004567 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 523794004568 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 523794004569 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 523794004570 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 523794004571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523794004572 NAD(P) binding site [chemical binding]; other site 523794004573 active site 523794004574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794004575 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 523794004576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 523794004577 classical (c) SDRs; Region: SDR_c; cd05233 523794004578 NAD(P) binding site [chemical binding]; other site 523794004579 active site 523794004580 phosphodiesterase YaeI; Provisional; Region: PRK11340 523794004581 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 523794004582 putative active site [active] 523794004583 putative metal binding site [ion binding]; other site 523794004584 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 523794004585 homotrimer interaction site [polypeptide binding]; other site 523794004586 putative active site [active] 523794004587 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 523794004588 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 523794004589 putative active site [active] 523794004590 putative metal binding site [ion binding]; other site 523794004591 PspC domain; Region: PspC; pfam04024 523794004592 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523794004593 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 523794004594 2-isopropylmalate synthase; Validated; Region: PRK00915 523794004595 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 523794004596 active site 523794004597 catalytic residues [active] 523794004598 metal binding site [ion binding]; metal-binding site 523794004599 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 523794004600 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 523794004601 aspartate racemase; Region: asp_race; TIGR00035 523794004602 Methyltransferase domain; Region: Methyltransf_31; pfam13847 523794004603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004604 S-adenosylmethionine binding site [chemical binding]; other site 523794004605 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 523794004606 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 523794004607 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 523794004608 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 523794004609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 523794004610 PYR/PP interface [polypeptide binding]; other site 523794004611 dimer interface [polypeptide binding]; other site 523794004612 TPP binding site [chemical binding]; other site 523794004613 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 523794004614 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 523794004615 TPP-binding site [chemical binding]; other site 523794004616 dimer interface [polypeptide binding]; other site 523794004617 threonine dehydratase; Provisional; Region: PRK08198 523794004618 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 523794004619 tetramer interface [polypeptide binding]; other site 523794004620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794004621 catalytic residue [active] 523794004622 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 523794004623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 523794004624 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 523794004625 substrate binding pocket [chemical binding]; other site 523794004626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523794004627 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 523794004628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794004629 binding surface 523794004630 TPR motif; other site 523794004631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 523794004632 TPR motif; other site 523794004633 binding surface 523794004634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794004635 TPR motif; other site 523794004636 binding surface 523794004637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794004639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 523794004640 TPR motif; other site 523794004641 binding surface 523794004642 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 523794004643 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 523794004644 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 523794004645 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 523794004646 active site 523794004647 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 523794004648 S-ribosylhomocysteinase; Provisional; Region: PRK02260 523794004649 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 523794004650 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 523794004651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 523794004652 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 523794004653 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 523794004654 dimerization interface [polypeptide binding]; other site 523794004655 domain crossover interface; other site 523794004656 redox-dependent activation switch; other site 523794004657 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 523794004658 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 523794004659 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 523794004660 trimer interface [polypeptide binding]; other site 523794004661 active site 523794004662 UDP-GlcNAc binding site [chemical binding]; other site 523794004663 lipid binding site [chemical binding]; lipid-binding site 523794004664 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523794004665 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523794004666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 523794004667 Surface antigen; Region: Bac_surface_Ag; pfam01103 523794004668 Family of unknown function (DUF490); Region: DUF490; pfam04357 523794004669 Family of unknown function (DUF490); Region: DUF490; pfam04357 523794004670 Family of unknown function (DUF490); Region: DUF490; pfam04357 523794004671 VanW like protein; Region: VanW; pfam04294 523794004672 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 523794004673 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 523794004674 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 523794004675 NAD synthase; Region: NAD_synthase; pfam02540 523794004676 Ligand Binding Site [chemical binding]; other site 523794004677 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 523794004678 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 523794004679 active site 523794004680 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523794004681 active site 523794004682 HIGH motif; other site 523794004683 nucleotide binding site [chemical binding]; other site 523794004684 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 523794004685 putative active site [active] 523794004686 catalytic residue [active] 523794004687 hypothetical protein; Validated; Region: PRK00110 523794004688 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 523794004689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004690 S-adenosylmethionine binding site [chemical binding]; other site 523794004691 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 523794004692 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 523794004693 dimer interface [polypeptide binding]; other site 523794004694 active site 523794004695 metal binding site [ion binding]; metal-binding site 523794004696 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 523794004697 Methyltransferase domain; Region: Methyltransf_23; pfam13489 523794004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004699 S-adenosylmethionine binding site [chemical binding]; other site 523794004700 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 523794004701 active site 523794004702 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 523794004703 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 523794004704 DHHA2 domain; Region: DHHA2; pfam02833 523794004705 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 523794004706 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 523794004707 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 523794004708 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 523794004709 YcfA-like protein; Region: YcfA; pfam07927 523794004710 triosephosphate isomerase; Provisional; Region: PRK14565 523794004711 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 523794004712 substrate binding site [chemical binding]; other site 523794004713 dimer interface [polypeptide binding]; other site 523794004714 catalytic triad [active] 523794004715 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 523794004716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523794004717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523794004718 WHG domain; Region: WHG; pfam13305 523794004719 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 523794004720 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 523794004721 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 523794004722 phosphoglyceromutase; Provisional; Region: PRK05434 523794004723 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794004724 Imelysin; Region: Peptidase_M75; pfam09375 523794004725 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 523794004726 Iron permease FTR1 family; Region: FTR1; cl00475 523794004727 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 523794004728 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 523794004729 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 523794004730 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 523794004731 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 523794004732 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 523794004733 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 523794004734 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 523794004735 agmatinase; Region: agmatinase; TIGR01230 523794004736 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 523794004737 putative active site [active] 523794004738 Mn binding site [ion binding]; other site 523794004739 spermidine synthase; Provisional; Region: PRK00811 523794004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004741 S-adenosylmethionine binding site [chemical binding]; other site 523794004742 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 523794004743 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 523794004744 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 523794004745 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 523794004746 homodimer interface [polypeptide binding]; other site 523794004747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794004748 catalytic residue [active] 523794004749 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 523794004750 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 523794004751 Membrane transport protein; Region: Mem_trans; pfam03547 523794004752 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 523794004753 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 523794004754 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 523794004755 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794004756 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794004757 Bacterial SH3 domain; Region: SH3_3; pfam08239 523794004758 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 523794004759 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 523794004760 Walker A/P-loop; other site 523794004761 ATP binding site [chemical binding]; other site 523794004762 Q-loop/lid; other site 523794004763 ABC transporter signature motif; other site 523794004764 Walker B; other site 523794004765 D-loop; other site 523794004766 H-loop/switch region; other site 523794004767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 523794004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794004769 dimer interface [polypeptide binding]; other site 523794004770 conserved gate region; other site 523794004771 putative PBP binding loops; other site 523794004772 ABC-ATPase subunit interface; other site 523794004773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 523794004774 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 523794004775 substrate binding pocket [chemical binding]; other site 523794004776 membrane-bound complex binding site; other site 523794004777 hinge residues; other site 523794004778 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 523794004779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 523794004780 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 523794004781 putative NAD(P) binding site [chemical binding]; other site 523794004782 catalytic Zn binding site [ion binding]; other site 523794004783 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 523794004784 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 523794004785 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 523794004786 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 523794004787 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 523794004788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794004789 RNA binding surface [nucleotide binding]; other site 523794004790 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 523794004791 active site 523794004792 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 523794004793 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 523794004794 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 523794004795 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 523794004796 Predicted permeases [General function prediction only]; Region: COG0795 523794004797 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 523794004798 Predicted permeases [General function prediction only]; Region: COG0795 523794004799 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 523794004800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 523794004801 alanine racemase; Reviewed; Region: alr; PRK00053 523794004802 active site 523794004803 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523794004804 dimer interface [polypeptide binding]; other site 523794004805 substrate binding site [chemical binding]; other site 523794004806 catalytic residues [active] 523794004807 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 523794004808 Protein export membrane protein; Region: SecD_SecF; pfam02355 523794004809 protein-export membrane protein SecD; Region: secD; TIGR01129 523794004810 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 523794004811 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 523794004812 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 523794004813 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 523794004814 motif 1; other site 523794004815 active site 523794004816 motif 2; other site 523794004817 motif 3; other site 523794004818 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 523794004819 DHHA1 domain; Region: DHHA1; pfam02272 523794004820 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 523794004821 conserved cys residue [active] 523794004822 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 523794004823 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 523794004824 Walker A/P-loop; other site 523794004825 ATP binding site [chemical binding]; other site 523794004826 Q-loop/lid; other site 523794004827 ABC transporter signature motif; other site 523794004828 Walker B; other site 523794004829 D-loop; other site 523794004830 H-loop/switch region; other site 523794004831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523794004832 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 523794004833 active site 523794004834 nucleotide binding site [chemical binding]; other site 523794004835 HIGH motif; other site 523794004836 KMSKS motif; other site 523794004837 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 523794004838 RmuC family; Region: RmuC; pfam02646 523794004839 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 523794004840 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 523794004841 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 523794004842 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 523794004843 Ligand Binding Site [chemical binding]; other site 523794004844 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 523794004845 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 523794004846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523794004847 catalytic residue [active] 523794004848 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 523794004849 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 523794004850 active site 523794004851 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 523794004852 metal-binding heat shock protein; Provisional; Region: PRK00016 523794004853 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 523794004854 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 523794004855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523794004856 Zn2+ binding site [ion binding]; other site 523794004857 Mg2+ binding site [ion binding]; other site 523794004858 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 523794004859 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 523794004860 DEAD/DEAH box helicase; Region: DEAD; pfam00270 523794004861 ATP binding site [chemical binding]; other site 523794004862 DEAD_2; Region: DEAD_2; pfam06733 523794004863 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 523794004864 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 523794004865 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 523794004866 Uncharacterized conserved protein [Function unknown]; Region: COG1284 523794004867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 523794004868 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 523794004869 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 523794004870 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 523794004871 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 523794004872 dimer interface [polypeptide binding]; other site 523794004873 motif 1; other site 523794004874 active site 523794004875 motif 2; other site 523794004876 motif 3; other site 523794004877 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 523794004878 anticodon binding site; other site 523794004879 Protein of unknown function (DUF554); Region: DUF554; pfam04474 523794004880 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 523794004881 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 523794004882 dimer interface [polypeptide binding]; other site 523794004883 anticodon binding site; other site 523794004884 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 523794004885 homodimer interface [polypeptide binding]; other site 523794004886 motif 1; other site 523794004887 active site 523794004888 motif 2; other site 523794004889 GAD domain; Region: GAD; pfam02938 523794004890 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 523794004891 active site 523794004892 motif 3; other site 523794004893 peptide chain release factor 1; Validated; Region: prfA; PRK00591 523794004894 This domain is found in peptide chain release factors; Region: PCRF; smart00937 523794004895 RF-1 domain; Region: RF-1; pfam00472 523794004896 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 523794004897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794004898 S-adenosylmethionine binding site [chemical binding]; other site 523794004899 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 523794004900 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 523794004901 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 523794004902 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523794004903 catalytic residues [active] 523794004904 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 523794004905 RuvA N terminal domain; Region: RuvA_N; pfam01330 523794004906 glutamate racemase; Provisional; Region: PRK00865 523794004907 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 523794004908 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 523794004909 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 523794004910 Uncharacterized conserved protein [Function unknown]; Region: COG0327 523794004911 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 523794004912 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 523794004913 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 523794004914 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 523794004915 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 523794004916 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 523794004917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 523794004918 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 523794004919 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 523794004920 DNA binding residues [nucleotide binding] 523794004921 DNA primase, catalytic core; Region: dnaG; TIGR01391 523794004922 CHC2 zinc finger; Region: zf-CHC2; cl17510 523794004923 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 523794004924 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 523794004925 active site 523794004926 metal binding site [ion binding]; metal-binding site 523794004927 interdomain interaction site; other site 523794004928 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 523794004929 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 523794004930 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 523794004931 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 523794004932 catalytic site [active] 523794004933 G-X2-G-X-G-K; other site 523794004934 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 523794004935 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 523794004936 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 523794004937 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 523794004938 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 523794004939 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 523794004940 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 523794004941 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 523794004942 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 523794004943 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 523794004944 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 523794004945 DNA binding site [nucleotide binding] 523794004946 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 523794004947 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 523794004948 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 523794004949 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 523794004950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 523794004951 RPB1 interaction site [polypeptide binding]; other site 523794004952 RPB10 interaction site [polypeptide binding]; other site 523794004953 RPB11 interaction site [polypeptide binding]; other site 523794004954 RPB3 interaction site [polypeptide binding]; other site 523794004955 RPB12 interaction site [polypeptide binding]; other site 523794004956 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 523794004957 peripheral dimer interface [polypeptide binding]; other site 523794004958 core dimer interface [polypeptide binding]; other site 523794004959 L10 interface [polypeptide binding]; other site 523794004960 L11 interface [polypeptide binding]; other site 523794004961 putative EF-Tu interaction site [polypeptide binding]; other site 523794004962 putative EF-G interaction site [polypeptide binding]; other site 523794004963 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 523794004964 23S rRNA interface [nucleotide binding]; other site 523794004965 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 523794004966 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 523794004967 mRNA/rRNA interface [nucleotide binding]; other site 523794004968 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 523794004969 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 523794004970 23S rRNA interface [nucleotide binding]; other site 523794004971 L7/L12 interface [polypeptide binding]; other site 523794004972 putative thiostrepton binding site; other site 523794004973 L25 interface [polypeptide binding]; other site 523794004974 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 523794004975 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 523794004976 putative homodimer interface [polypeptide binding]; other site 523794004977 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 523794004978 heterodimer interface [polypeptide binding]; other site 523794004979 homodimer interface [polypeptide binding]; other site 523794004980 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 523794004981 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 523794004982 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794004983 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 523794004984 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 523794004985 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 523794004986 PYR/PP interface [polypeptide binding]; other site 523794004987 dimer interface [polypeptide binding]; other site 523794004988 TPP binding site [chemical binding]; other site 523794004989 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 523794004990 transketolase; Reviewed; Region: PRK05899 523794004991 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 523794004992 TPP-binding site [chemical binding]; other site 523794004993 dimer interface [polypeptide binding]; other site 523794004994 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 523794004995 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 523794004996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 523794004997 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 523794004998 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 523794004999 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 523794005000 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523794005001 active site turn [active] 523794005002 phosphorylation site [posttranslational modification] 523794005003 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523794005004 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 523794005005 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 523794005006 substrate binding [chemical binding]; other site 523794005007 active site 523794005008 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 523794005009 Transcriptional regulators [Transcription]; Region: PurR; COG1609 523794005010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 523794005011 DNA binding site [nucleotide binding] 523794005012 domain linker motif; other site 523794005013 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 523794005014 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 523794005015 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 523794005016 catalytic triad [active] 523794005017 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 523794005018 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794005019 catalytic residues [active] 523794005020 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 523794005021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794005022 FeS/SAM binding site; other site 523794005023 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 523794005024 Pyruvate formate lyase 1; Region: PFL1; cd01678 523794005025 coenzyme A binding site [chemical binding]; other site 523794005026 active site 523794005027 catalytic residues [active] 523794005028 glycine loop; other site 523794005029 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 523794005030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794005031 FeS/SAM binding site; other site 523794005032 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 523794005033 elongation factor Tu; Reviewed; Region: PRK00049 523794005034 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 523794005035 G1 box; other site 523794005036 GEF interaction site [polypeptide binding]; other site 523794005037 GTP/Mg2+ binding site [chemical binding]; other site 523794005038 Switch I region; other site 523794005039 G2 box; other site 523794005040 G3 box; other site 523794005041 Switch II region; other site 523794005042 G4 box; other site 523794005043 G5 box; other site 523794005044 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 523794005045 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 523794005046 Antibiotic Binding Site [chemical binding]; other site 523794005047 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 523794005048 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 523794005049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794005050 FeS/SAM binding site; other site 523794005051 TRAM domain; Region: TRAM; pfam01938 523794005052 transcription termination factor Rho; Provisional; Region: rho; PRK09376 523794005053 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 523794005054 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523794005055 RNA binding site [nucleotide binding]; other site 523794005056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523794005057 Walker A motif; other site 523794005058 ATP binding site [chemical binding]; other site 523794005059 Walker B motif; other site 523794005060 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 523794005061 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 523794005062 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 523794005063 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 523794005064 active site 523794005065 nucleophile elbow; other site 523794005066 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 523794005067 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 523794005068 dimerization interface [polypeptide binding]; other site 523794005069 DPS ferroxidase diiron center [ion binding]; other site 523794005070 ion pore; other site 523794005071 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 523794005072 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 523794005073 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 523794005074 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 523794005075 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 523794005076 G1 box; other site 523794005077 GTP/Mg2+ binding site [chemical binding]; other site 523794005078 Switch I region; other site 523794005079 G2 box; other site 523794005080 G3 box; other site 523794005081 Switch II region; other site 523794005082 G4 box; other site 523794005083 G5 box; other site 523794005084 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 523794005085 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 523794005086 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 523794005087 CoA-binding site [chemical binding]; other site 523794005088 ATP-binding [chemical binding]; other site 523794005089 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 523794005090 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 523794005091 carboxyltransferase (CT) interaction site; other site 523794005092 biotinylation site [posttranslational modification]; other site 523794005093 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 523794005094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 523794005095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 523794005096 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 523794005097 Asp23 family; Region: Asp23; pfam03780 523794005098 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 523794005099 putative RNA binding site [nucleotide binding]; other site 523794005100 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 523794005101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 523794005102 active site 523794005103 nucleotide binding site [chemical binding]; other site 523794005104 HIGH motif; other site 523794005105 KMSKS motif; other site 523794005106 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 523794005107 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 523794005108 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 523794005109 SLBB domain; Region: SLBB; pfam10531 523794005110 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 523794005111 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 523794005112 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 523794005113 FMN binding site [chemical binding]; other site 523794005114 substrate binding site [chemical binding]; other site 523794005115 putative catalytic residue [active] 523794005116 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794005117 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523794005118 catalytic residues [active] 523794005119 UDP-glucose 4-epimerase; Region: PLN02240 523794005120 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 523794005121 NAD binding site [chemical binding]; other site 523794005122 homodimer interface [polypeptide binding]; other site 523794005123 active site 523794005124 substrate binding site [chemical binding]; other site 523794005125 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 523794005126 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 523794005127 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523794005128 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 523794005129 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523794005130 active site turn [active] 523794005131 phosphorylation site [posttranslational modification] 523794005132 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 523794005133 HPr interaction site; other site 523794005134 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523794005135 active site 523794005136 phosphorylation site [posttranslational modification] 523794005137 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 523794005138 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 523794005139 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 523794005140 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 523794005141 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 523794005142 dimer interface [polypeptide binding]; other site 523794005143 active site 523794005144 glycine loop; other site 523794005145 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 523794005146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794005147 FeS/SAM binding site; other site 523794005148 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 523794005149 active site 523794005150 intersubunit interactions; other site 523794005151 catalytic residue [active] 523794005152 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 523794005153 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 523794005154 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 523794005155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523794005156 dimerization interface [polypeptide binding]; other site 523794005157 putative DNA binding site [nucleotide binding]; other site 523794005158 putative Zn2+ binding site [ion binding]; other site 523794005159 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 523794005160 active site residue [active] 523794005161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794005162 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 523794005163 catalytic residues [active] 523794005164 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 523794005165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 523794005166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 523794005167 META domain; Region: META; pfam03724 523794005168 META domain; Region: META; pfam03724 523794005169 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 523794005170 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 523794005171 EamA-like transporter family; Region: EamA; pfam00892 523794005172 Adhesion protein FadA; Region: FadA; pfam09403 523794005173 Adhesion protein FadA; Region: FadA; pfam09403 523794005174 enolase; Provisional; Region: eno; PRK00077 523794005175 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 523794005176 dimer interface [polypeptide binding]; other site 523794005177 metal binding site [ion binding]; metal-binding site 523794005178 substrate binding pocket [chemical binding]; other site 523794005179 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 523794005180 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 523794005181 active site 523794005182 metal binding site [ion binding]; metal-binding site 523794005183 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523794005184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in integron-associated MazG (iMazG) proteins; Region: NTP-PPase_iMazG; cd11536 523794005185 homodimer interface [polypeptide binding]; other site 523794005186 putative chemical substrate binding site [chemical binding]; other site 523794005187 oligomer interface [polypeptide binding]; other site 523794005188 metal binding site [ion binding]; metal-binding site 523794005189 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 523794005190 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 523794005191 active site 523794005192 metal binding site [ion binding]; metal-binding site 523794005193 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 523794005194 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 523794005195 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 523794005196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523794005197 Zn2+ binding site [ion binding]; other site 523794005198 Mg2+ binding site [ion binding]; other site 523794005199 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 523794005200 synthetase active site [active] 523794005201 NTP binding site [chemical binding]; other site 523794005202 metal binding site [ion binding]; metal-binding site 523794005203 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 523794005204 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 523794005205 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 523794005206 OpgC protein; Region: OpgC_C; cl17858 523794005207 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 523794005208 catalytic triad [active] 523794005209 catalytic triad [active] 523794005210 oxyanion hole [active] 523794005211 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 523794005212 active site 523794005213 catalytic triad [active] 523794005214 oxyanion hole [active] 523794005215 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 523794005216 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 523794005217 active site 523794005218 RNA/DNA hybrid binding site [nucleotide binding]; other site 523794005219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 523794005220 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 523794005221 NAD(P) binding site [chemical binding]; other site 523794005222 active site 523794005223 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 523794005224 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 523794005225 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 523794005226 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 523794005227 NodB motif; other site 523794005228 active site 523794005229 catalytic site [active] 523794005230 Zn binding site [ion binding]; other site 523794005231 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 523794005232 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 523794005233 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 523794005234 active site 523794005235 HIGH motif; other site 523794005236 KMSK motif region; other site 523794005237 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 523794005238 tRNA binding surface [nucleotide binding]; other site 523794005239 anticodon binding site; other site 523794005240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794005241 catalytic core [active] 523794005242 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 523794005243 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 523794005244 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 523794005245 dimer interface [polypeptide binding]; other site 523794005246 active site 523794005247 Schiff base residues; other site 523794005248 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 523794005249 TrkA-N domain; Region: TrkA_N; pfam02254 523794005250 TrkA-C domain; Region: TrkA_C; pfam02080 523794005251 TrkA-N domain; Region: TrkA_N; pfam02254 523794005252 TrkA-C domain; Region: TrkA_C; pfam02080 523794005253 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 523794005254 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 523794005255 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 523794005256 Class III ribonucleotide reductase; Region: RNR_III; cd01675 523794005257 effector binding site; other site 523794005258 active site 523794005259 Zn binding site [ion binding]; other site 523794005260 glycine loop; other site 523794005261 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 523794005262 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 523794005263 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 523794005264 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 523794005265 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 523794005266 trimer interface [polypeptide binding]; other site 523794005267 active site 523794005268 substrate binding site [chemical binding]; other site 523794005269 CoA binding site [chemical binding]; other site 523794005270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794005271 binding surface 523794005272 TPR motif; other site 523794005273 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 523794005274 dimer interface [polypeptide binding]; other site 523794005275 catalytic triad [active] 523794005276 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 523794005277 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 523794005278 Tetramer interface [polypeptide binding]; other site 523794005279 active site 523794005280 FMN-binding site [chemical binding]; other site 523794005281 Predicted peptidase [General function prediction only]; Region: COG4099 523794005282 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 523794005283 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 523794005284 hinge; other site 523794005285 active site 523794005286 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 523794005287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794005288 S-adenosylmethionine binding site [chemical binding]; other site 523794005289 Protein of unknown function DUF262; Region: DUF262; pfam03235 523794005290 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794005291 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794005292 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794005293 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 523794005294 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 523794005295 active site 523794005296 dimer interface [polypeptide binding]; other site 523794005297 metal binding site [ion binding]; metal-binding site 523794005298 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 523794005299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 523794005300 prephenate dehydrogenase; Validated; Region: PRK08507 523794005301 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 523794005302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794005303 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 523794005304 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 523794005305 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 523794005306 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 523794005307 SmpB-tmRNA interface; other site 523794005308 ribonuclease R; Region: RNase_R; TIGR02063 523794005309 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 523794005310 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 523794005311 RNB domain; Region: RNB; pfam00773 523794005312 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 523794005313 RNA binding site [nucleotide binding]; other site 523794005314 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 523794005315 Zn2+ binding site [ion binding]; other site 523794005316 Mg2+ binding site [ion binding]; other site 523794005317 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 523794005318 rRNA binding site [nucleotide binding]; other site 523794005319 predicted 30S ribosome binding site; other site 523794005320 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 523794005321 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 523794005322 30S ribosomal protein S13; Region: bact_S13; TIGR03631 523794005323 30S ribosomal protein S11; Validated; Region: PRK05309 523794005324 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 523794005325 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 523794005326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794005327 RNA binding surface [nucleotide binding]; other site 523794005328 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 523794005329 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 523794005330 alphaNTD - beta interaction site [polypeptide binding]; other site 523794005331 alphaNTD homodimer interface [polypeptide binding]; other site 523794005332 alphaNTD - beta' interaction site [polypeptide binding]; other site 523794005333 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 523794005334 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 523794005335 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 523794005336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794005337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794005338 dimerization interface [polypeptide binding]; other site 523794005339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794005340 dimer interface [polypeptide binding]; other site 523794005341 phosphorylation site [posttranslational modification] 523794005342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794005343 ATP binding site [chemical binding]; other site 523794005344 Mg2+ binding site [ion binding]; other site 523794005345 G-X-G motif; other site 523794005346 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 523794005347 metal binding site 2 [ion binding]; metal-binding site 523794005348 putative DNA binding helix; other site 523794005349 metal binding site 1 [ion binding]; metal-binding site 523794005350 dimer interface [polypeptide binding]; other site 523794005351 structural Zn2+ binding site [ion binding]; other site 523794005352 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 523794005353 Ferritin-like domain; Region: Ferritin; pfam00210 523794005354 ferroxidase diiron center [ion binding]; other site 523794005355 Type II/IV secretion system protein; Region: T2SE; pfam00437 523794005356 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 523794005357 Walker A motif; other site 523794005358 ATP binding site [chemical binding]; other site 523794005359 Walker B motif; other site 523794005360 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 523794005361 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 523794005362 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523794005363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794005364 active site 523794005365 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 523794005366 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 523794005367 Substrate binding site; other site 523794005368 Mg++ binding site; other site 523794005369 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 523794005370 active site 523794005371 substrate binding site [chemical binding]; other site 523794005372 CoA binding site [chemical binding]; other site 523794005373 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 523794005374 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 523794005375 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 523794005376 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523794005377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523794005378 active site 523794005379 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 523794005380 putative catalytic site [active] 523794005381 putative metal binding site [ion binding]; other site 523794005382 putative phosphate binding site [ion binding]; other site 523794005383 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 523794005384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794005385 Coenzyme A binding pocket [chemical binding]; other site 523794005386 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 523794005387 glycogen synthase; Provisional; Region: glgA; PRK00654 523794005388 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 523794005389 ADP-binding pocket [chemical binding]; other site 523794005390 homodimer interface [polypeptide binding]; other site 523794005391 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 523794005392 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 523794005393 ligand binding site; other site 523794005394 oligomer interface; other site 523794005395 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 523794005396 dimer interface [polypeptide binding]; other site 523794005397 N-terminal domain interface [polypeptide binding]; other site 523794005398 sulfate 1 binding site; other site 523794005399 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 523794005400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794005401 S-adenosylmethionine binding site [chemical binding]; other site 523794005402 Uncharacterized conserved protein [Function unknown]; Region: COG1479 523794005403 Protein of unknown function DUF262; Region: DUF262; pfam03235 523794005404 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 523794005405 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 523794005406 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 523794005407 Soluble P-type ATPase [General function prediction only]; Region: COG4087 523794005408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794005409 catalytic core [active] 523794005410 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 523794005411 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 523794005412 MutS domain I; Region: MutS_I; pfam01624 523794005413 MutS domain II; Region: MutS_II; pfam05188 523794005414 MutS domain III; Region: MutS_III; pfam05192 523794005415 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 523794005416 Walker A/P-loop; other site 523794005417 ATP binding site [chemical binding]; other site 523794005418 Q-loop/lid; other site 523794005419 ABC transporter signature motif; other site 523794005420 Walker B; other site 523794005421 D-loop; other site 523794005422 H-loop/switch region; other site 523794005423 OstA-like protein; Region: OstA; cl00844 523794005424 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 523794005425 OstA-like protein; Region: OstA; cl00844 523794005426 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 523794005427 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 523794005428 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 523794005429 active site 523794005430 metal binding site [ion binding]; metal-binding site 523794005431 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 523794005432 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 523794005433 putative catalytic cysteine [active] 523794005434 gamma-glutamyl kinase; Provisional; Region: PRK05429 523794005435 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 523794005436 nucleotide binding site [chemical binding]; other site 523794005437 homotetrameric interface [polypeptide binding]; other site 523794005438 putative phosphate binding site [ion binding]; other site 523794005439 putative allosteric binding site; other site 523794005440 PUA domain; Region: PUA; pfam01472 523794005441 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 523794005442 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 523794005443 active site 523794005444 Na/Ca binding site [ion binding]; other site 523794005445 catalytic site [active] 523794005446 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 523794005447 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 523794005448 Ligand binding site; other site 523794005449 oligomer interface; other site 523794005450 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 523794005451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 523794005452 Walker A motif; other site 523794005453 ATP binding site [chemical binding]; other site 523794005454 Walker B motif; other site 523794005455 arginine finger; other site 523794005456 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 523794005457 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 523794005458 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 523794005459 replicative DNA helicase; Region: DnaB; TIGR00665 523794005460 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 523794005461 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 523794005462 Walker A motif; other site 523794005463 ATP binding site [chemical binding]; other site 523794005464 Walker B motif; other site 523794005465 DNA binding loops [nucleotide binding] 523794005466 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 523794005467 Peptidase family U32; Region: Peptidase_U32; pfam01136 523794005468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794005469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794005470 active site 523794005471 phosphorylation site [posttranslational modification] 523794005472 intermolecular recognition site; other site 523794005473 dimerization interface [polypeptide binding]; other site 523794005474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794005475 DNA binding site [nucleotide binding] 523794005476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794005477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 523794005478 dimerization interface [polypeptide binding]; other site 523794005479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794005480 dimer interface [polypeptide binding]; other site 523794005481 phosphorylation site [posttranslational modification] 523794005482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794005483 ATP binding site [chemical binding]; other site 523794005484 Mg2+ binding site [ion binding]; other site 523794005485 G-X-G motif; other site 523794005486 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 523794005487 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 523794005488 active site 523794005489 substrate binding site [chemical binding]; other site 523794005490 metal binding site [ion binding]; metal-binding site 523794005491 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 523794005492 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 523794005493 catalytic triad [active] 523794005494 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 523794005495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 523794005496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 523794005497 catalytic residue [active] 523794005498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794005499 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794005500 active site 523794005501 motif I; other site 523794005502 motif II; other site 523794005503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794005504 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 523794005505 DNA polymerase III subunit delta'; Validated; Region: PRK08485 523794005506 rod shape-determining protein MreB; Provisional; Region: PRK13930 523794005507 MreB and similar proteins; Region: MreB_like; cd10225 523794005508 nucleotide binding site [chemical binding]; other site 523794005509 Mg binding site [ion binding]; other site 523794005510 putative protofilament interaction site [polypeptide binding]; other site 523794005511 RodZ interaction site [polypeptide binding]; other site 523794005512 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 523794005513 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 523794005514 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 523794005515 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 523794005516 dimerization interface 3.5A [polypeptide binding]; other site 523794005517 active site 523794005518 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 523794005519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794005520 Coenzyme A binding pocket [chemical binding]; other site 523794005521 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 523794005522 metal-binding site [ion binding] 523794005523 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 523794005524 catalytic triad [active] 523794005525 putative active site [active] 523794005526 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 523794005527 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794005528 Domain of unknown function (DUF333); Region: DUF333; pfam03891 523794005529 Domain of unknown function (DUF333); Region: DUF333; pfam03891 523794005530 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 523794005531 AIPR protein; Region: AIPR; pfam10592 523794005532 GMP synthase; Reviewed; Region: guaA; PRK00074 523794005533 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 523794005534 AMP/PPi binding site [chemical binding]; other site 523794005535 candidate oxyanion hole; other site 523794005536 catalytic triad [active] 523794005537 potential glutamine specificity residues [chemical binding]; other site 523794005538 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 523794005539 ATP Binding subdomain [chemical binding]; other site 523794005540 Ligand Binding sites [chemical binding]; other site 523794005541 Dimerization subdomain; other site 523794005542 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 523794005543 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 523794005544 putative catalytic cysteine [active] 523794005545 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 523794005546 putative active site [active] 523794005547 metal binding site [ion binding]; metal-binding site 523794005548 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 523794005549 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 523794005550 tetrameric interface [polypeptide binding]; other site 523794005551 activator binding site; other site 523794005552 NADP binding site [chemical binding]; other site 523794005553 substrate binding site [chemical binding]; other site 523794005554 catalytic residues [active] 523794005555 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 523794005556 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 523794005557 ligand binding site [chemical binding]; other site 523794005558 flexible hinge region; other site 523794005559 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 523794005560 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 523794005561 glutaminase active site [active] 523794005562 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 523794005563 dimer interface [polypeptide binding]; other site 523794005564 active site 523794005565 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 523794005566 dimer interface [polypeptide binding]; other site 523794005567 active site 523794005568 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 523794005569 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 523794005570 Peptidase family M50; Region: Peptidase_M50; pfam02163 523794005571 active site 523794005572 putative substrate binding region [chemical binding]; other site 523794005573 Uncharacterized conserved protein [Function unknown]; Region: COG1739 523794005574 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 523794005575 hypothetical protein; Validated; Region: PRK00153 523794005576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 523794005577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 523794005578 putative substrate translocation pore; other site 523794005579 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 523794005580 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 523794005581 active site 523794005582 substrate binding site [chemical binding]; other site 523794005583 metal binding site [ion binding]; metal-binding site 523794005584 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 523794005585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 523794005586 FeS/SAM binding site; other site 523794005587 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 523794005588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 523794005589 catalytic residue [active] 523794005590 Protein of unknown function (DUF552); Region: DUF552; pfam04472 523794005591 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 523794005592 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 523794005593 protein binding site [polypeptide binding]; other site 523794005594 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 523794005595 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 523794005596 ABC1 family; Region: ABC1; cl17513 523794005597 Protein of unknown function (DUF456); Region: DUF456; pfam04306 523794005598 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 523794005599 acetyllysine binding site; other site 523794005600 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 523794005601 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 523794005602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 523794005603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 523794005604 Uncharacterized conserved protein [Function unknown]; Region: COG1359 523794005605 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 523794005606 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 523794005607 putative active site [active] 523794005608 UGMP family protein; Validated; Region: PRK09604 523794005609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 523794005610 nucleotide binding site [chemical binding]; other site 523794005611 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794005612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794005613 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794005614 active site 523794005615 motif I; other site 523794005616 motif II; other site 523794005617 Response regulator receiver domain; Region: Response_reg; pfam00072 523794005618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794005619 active site 523794005620 phosphorylation site [posttranslational modification] 523794005621 intermolecular recognition site; other site 523794005622 dimerization interface [polypeptide binding]; other site 523794005623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794005624 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 523794005625 active site 523794005626 motif I; other site 523794005627 motif II; other site 523794005628 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 523794005629 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 523794005630 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 523794005631 MutS domain III; Region: MutS_III; pfam05192 523794005632 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 523794005633 Walker A/P-loop; other site 523794005634 ATP binding site [chemical binding]; other site 523794005635 Q-loop/lid; other site 523794005636 ABC transporter signature motif; other site 523794005637 Walker B; other site 523794005638 D-loop; other site 523794005639 H-loop/switch region; other site 523794005640 Smr domain; Region: Smr; pfam01713 523794005641 AAA domain; Region: AAA_21; pfam13304 523794005642 RloB-like protein; Region: RloB; pfam13707 523794005643 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 523794005644 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 523794005645 active site 523794005646 HIGH motif; other site 523794005647 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 523794005648 KMSKS motif; other site 523794005649 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 523794005650 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 523794005651 Flavoprotein; Region: Flavoprotein; pfam02441 523794005652 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 523794005653 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 523794005654 Peptidase family M23; Region: Peptidase_M23; pfam01551 523794005655 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 523794005656 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794005657 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 523794005658 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 523794005659 active site 523794005660 adenylate kinase; Reviewed; Region: adk; PRK00279 523794005661 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 523794005662 AMP-binding site [chemical binding]; other site 523794005663 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 523794005664 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 523794005665 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 523794005666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 523794005667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 523794005668 homodimer interface [polypeptide binding]; other site 523794005669 catalytic residue [active] 523794005670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 523794005671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 523794005672 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 523794005673 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 523794005674 DHH family; Region: DHH; pfam01368 523794005675 DHHA1 domain; Region: DHHA1; pfam02272 523794005676 Sporulation related domain; Region: SPOR; cl10051 523794005677 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 523794005678 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 523794005679 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 523794005680 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 523794005681 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 523794005682 active site 523794005683 trimer interface [polypeptide binding]; other site 523794005684 allosteric site; other site 523794005685 active site lid [active] 523794005686 hexamer (dimer of trimers) interface [polypeptide binding]; other site 523794005687 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 523794005688 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 523794005689 active site 523794005690 dimer interface [polypeptide binding]; other site 523794005691 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 523794005692 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 523794005693 active site 523794005694 dimer interface [polypeptide binding]; other site 523794005695 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 523794005696 dimer interface [polypeptide binding]; other site 523794005697 active site 523794005698 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 523794005699 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 523794005700 oligomer interface [polypeptide binding]; other site 523794005701 putative active site [active] 523794005702 metal binding site [ion binding]; metal-binding site 523794005703 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 523794005704 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 523794005705 homodimer interface [polypeptide binding]; other site 523794005706 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 523794005707 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 523794005708 active site 523794005709 homodimer interface [polypeptide binding]; other site 523794005710 catalytic site [active] 523794005711 hypothetical protein; Reviewed; Region: PRK00024 523794005712 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 523794005713 MPN+ (JAMM) motif; other site 523794005714 Zinc-binding site [ion binding]; other site 523794005715 PSP1 C-terminal conserved region; Region: PSP1; cl00770 523794005716 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 523794005717 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 523794005718 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 523794005719 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 523794005720 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 523794005721 NADP binding site [chemical binding]; other site 523794005722 active site 523794005723 putative substrate binding site [chemical binding]; other site 523794005724 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 523794005725 active site 523794005726 catalytic residues [active] 523794005727 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 523794005728 active site 523794005729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 523794005730 active site 523794005731 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 523794005732 Ligand binding site; other site 523794005733 Cupin domain; Region: Cupin_2; cl17218 523794005734 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 523794005735 Ligand binding site; other site 523794005736 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 523794005737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794005738 motif II; other site 523794005739 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 523794005740 putative active site [active] 523794005741 catalytic site [active] 523794005742 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523794005743 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 523794005744 Ligand binding site; other site 523794005745 Putative Catalytic site; other site 523794005746 DXD motif; other site 523794005747 Predicted membrane protein [Function unknown]; Region: COG2246 523794005748 GtrA-like protein; Region: GtrA; pfam04138 523794005749 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00163 523794005750 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 523794005751 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 523794005752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 523794005753 active site 523794005754 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 523794005755 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 523794005756 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 523794005757 Walker A/P-loop; other site 523794005758 ATP binding site [chemical binding]; other site 523794005759 Q-loop/lid; other site 523794005760 ABC transporter signature motif; other site 523794005761 Walker B; other site 523794005762 D-loop; other site 523794005763 H-loop/switch region; other site 523794005764 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 523794005765 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 523794005766 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 523794005767 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 523794005768 substrate binding site; other site 523794005769 tetramer interface; other site 523794005770 Bacterial sugar transferase; Region: Bac_transf; pfam02397 523794005771 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 523794005772 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 523794005773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 523794005774 active site 523794005775 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 523794005776 putative active site [active] 523794005777 catalytic residue [active] 523794005778 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 523794005779 Thiamine pyrophosphokinase; Region: TPK; cd07995 523794005780 active site 523794005781 dimerization interface [polypeptide binding]; other site 523794005782 thiamine binding site [chemical binding]; other site 523794005783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 523794005784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 523794005785 dimer interface [polypeptide binding]; other site 523794005786 phosphorylation site [posttranslational modification] 523794005787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794005788 ATP binding site [chemical binding]; other site 523794005789 Mg2+ binding site [ion binding]; other site 523794005790 G-X-G motif; other site 523794005791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 523794005792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 523794005793 active site 523794005794 phosphorylation site [posttranslational modification] 523794005795 intermolecular recognition site; other site 523794005796 dimerization interface [polypeptide binding]; other site 523794005797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 523794005798 DNA binding site [nucleotide binding] 523794005799 HRDC domain; Region: HRDC; pfam00570 523794005800 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 523794005801 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 523794005802 putative tRNA-binding site [nucleotide binding]; other site 523794005803 B3/4 domain; Region: B3_4; pfam03483 523794005804 tRNA synthetase B5 domain; Region: B5; smart00874 523794005805 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 523794005806 dimer interface [polypeptide binding]; other site 523794005807 motif 1; other site 523794005808 motif 3; other site 523794005809 motif 2; other site 523794005810 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 523794005811 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 523794005812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 523794005813 Coenzyme A binding pocket [chemical binding]; other site 523794005814 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 523794005815 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 523794005816 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 523794005817 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 523794005818 dimer interface [polypeptide binding]; other site 523794005819 motif 1; other site 523794005820 active site 523794005821 motif 2; other site 523794005822 motif 3; other site 523794005823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 523794005824 dimerization interface [polypeptide binding]; other site 523794005825 putative DNA binding site [nucleotide binding]; other site 523794005826 putative Zn2+ binding site [ion binding]; other site 523794005827 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 523794005828 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 523794005829 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 523794005830 NAD(P) binding site [chemical binding]; other site 523794005831 Predicted peptidase [General function prediction only]; Region: COG4099 523794005832 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 523794005833 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 523794005834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 523794005835 Probable transposase; Region: OrfB_IS605; pfam01385 523794005836 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 523794005837 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 523794005838 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 523794005839 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 523794005840 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 523794005841 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523794005842 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523794005843 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 523794005844 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 523794005845 GTPase/Zn-binding domain interface [polypeptide binding]; other site 523794005846 GTP/Mg2+ binding site [chemical binding]; other site 523794005847 G4 box; other site 523794005848 G5 box; other site 523794005849 G1 box; other site 523794005850 Switch I region; other site 523794005851 G2 box; other site 523794005852 G3 box; other site 523794005853 Switch II region; other site 523794005854 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 523794005855 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 523794005856 substrate binding site [chemical binding]; other site 523794005857 hexamer interface [polypeptide binding]; other site 523794005858 metal binding site [ion binding]; metal-binding site 523794005859 Transcriptional regulators [Transcription]; Region: MarR; COG1846 523794005860 MarR family; Region: MarR_2; pfam12802 523794005861 Abi-like protein; Region: Abi_2; cl01988 523794005862 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 523794005863 Domain of unknown function (DUF814); Region: DUF814; pfam05670 523794005864 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 523794005865 dimerization domain swap beta strand [polypeptide binding]; other site 523794005866 regulatory protein interface [polypeptide binding]; other site 523794005867 active site 523794005868 regulatory phosphorylation site [posttranslational modification]; other site 523794005869 CTP synthetase; Validated; Region: pyrG; PRK05380 523794005870 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 523794005871 Catalytic site [active] 523794005872 active site 523794005873 UTP binding site [chemical binding]; other site 523794005874 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 523794005875 active site 523794005876 putative oxyanion hole; other site 523794005877 catalytic triad [active] 523794005878 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 523794005879 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 523794005880 intersubunit interface [polypeptide binding]; other site 523794005881 active site 523794005882 zinc binding site [ion binding]; other site 523794005883 Na+ binding site [ion binding]; other site 523794005884 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 523794005885 active site 523794005886 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 523794005887 seryl-tRNA synthetase; Provisional; Region: PRK05431 523794005888 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 523794005889 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 523794005890 dimer interface [polypeptide binding]; other site 523794005891 active site 523794005892 motif 1; other site 523794005893 motif 2; other site 523794005894 motif 3; other site 523794005895 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 523794005896 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 523794005897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 523794005898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 523794005899 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 523794005900 catalytic residues [active] 523794005901 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 523794005902 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 523794005903 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 523794005904 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 523794005905 NAD binding site [chemical binding]; other site 523794005906 substrate binding site [chemical binding]; other site 523794005907 homodimer interface [polypeptide binding]; other site 523794005908 active site 523794005909 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 523794005910 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 523794005911 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 523794005912 putative ligand binding site [chemical binding]; other site 523794005913 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 523794005914 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 523794005915 putative ligand binding site [chemical binding]; other site 523794005916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 523794005917 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 523794005918 TM-ABC transporter signature motif; other site 523794005919 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 523794005920 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 523794005921 TM-ABC transporter signature motif; other site 523794005922 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 523794005923 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 523794005924 Walker A/P-loop; other site 523794005925 ATP binding site [chemical binding]; other site 523794005926 Q-loop/lid; other site 523794005927 ABC transporter signature motif; other site 523794005928 Walker B; other site 523794005929 D-loop; other site 523794005930 H-loop/switch region; other site 523794005931 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 523794005932 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 523794005933 Walker A/P-loop; other site 523794005934 ATP binding site [chemical binding]; other site 523794005935 Q-loop/lid; other site 523794005936 ABC transporter signature motif; other site 523794005937 Walker B; other site 523794005938 D-loop; other site 523794005939 H-loop/switch region; other site 523794005940 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 523794005941 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 523794005942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 523794005943 DNA-binding site [nucleotide binding]; DNA binding site 523794005944 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 523794005945 GrpE; Region: GrpE; pfam01025 523794005946 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 523794005947 dimer interface [polypeptide binding]; other site 523794005948 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 523794005949 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 523794005950 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 523794005951 nucleotide binding site [chemical binding]; other site 523794005952 NEF interaction site [polypeptide binding]; other site 523794005953 SBD interface [polypeptide binding]; other site 523794005954 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 523794005955 active site 523794005956 catalytic residues [active] 523794005957 chaperone protein DnaJ; Provisional; Region: PRK10767 523794005958 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 523794005959 HSP70 interaction site [polypeptide binding]; other site 523794005960 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 523794005961 substrate binding site [polypeptide binding]; other site 523794005962 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 523794005963 Zn binding sites [ion binding]; other site 523794005964 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 523794005965 dimer interface [polypeptide binding]; other site 523794005966 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 523794005967 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 523794005968 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 523794005969 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 523794005970 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 523794005971 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 523794005972 minor groove reading motif; other site 523794005973 helix-hairpin-helix signature motif; other site 523794005974 active site 523794005975 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 523794005976 catalytic triad [active] 523794005977 putative active site [active] 523794005978 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 523794005979 Autotransporter beta-domain; Region: Autotransporter; pfam03797 523794005980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 523794005981 binding surface 523794005982 TPR motif; other site 523794005983 Tetratricopeptide repeat; Region: TPR_16; pfam13432 523794005984 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 523794005985 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 523794005986 active site 523794005987 FMN binding site [chemical binding]; other site 523794005988 substrate binding site [chemical binding]; other site 523794005989 catalytic residues [active] 523794005990 homodimer interface [polypeptide binding]; other site 523794005991 NAD-dependent deacetylase; Provisional; Region: PRK00481 523794005992 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 523794005993 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 523794005994 Low molecular weight phosphatase family; Region: LMWPc; cd00115 523794005995 active site 523794005996 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 523794005997 beta-galactosidase; Region: BGL; TIGR03356 523794005998 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 523794005999 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 523794006000 active site turn [active] 523794006001 phosphorylation site [posttranslational modification] 523794006002 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 523794006003 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 523794006004 HPr interaction site; other site 523794006005 glycerol kinase (GK) interaction site [polypeptide binding]; other site 523794006006 active site 523794006007 phosphorylation site [posttranslational modification] 523794006008 primosome assembly protein PriA; Validated; Region: PRK05580 523794006009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794006010 ATP binding site [chemical binding]; other site 523794006011 putative Mg++ binding site [ion binding]; other site 523794006012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794006013 ATP-binding site [chemical binding]; other site 523794006014 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 523794006015 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 523794006016 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 523794006017 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 523794006018 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 523794006019 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 523794006020 GatB domain; Region: GatB_Yqey; smart00845 523794006021 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 523794006022 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 523794006023 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 523794006024 DNA methylase; Region: N6_N4_Mtase; cl17433 523794006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 523794006026 S-adenosylmethionine binding site [chemical binding]; other site 523794006027 DNA methylase; Region: N6_N4_Mtase; cl17433 523794006028 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 523794006029 Zeta toxin; Region: Zeta_toxin; pfam06414 523794006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 523794006031 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 523794006032 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 523794006033 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794006034 RNA binding surface [nucleotide binding]; other site 523794006035 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 523794006036 active site 523794006037 uracil binding [chemical binding]; other site 523794006038 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 523794006039 rod shape-determining protein MreB; Provisional; Region: PRK13927 523794006040 MreB and similar proteins; Region: MreB_like; cd10225 523794006041 nucleotide binding site [chemical binding]; other site 523794006042 Mg binding site [ion binding]; other site 523794006043 putative protofilament interaction site [polypeptide binding]; other site 523794006044 RodZ interaction site [polypeptide binding]; other site 523794006045 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 523794006046 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 523794006047 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 523794006048 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 523794006049 catalytic residue [active] 523794006050 putative FPP diphosphate binding site; other site 523794006051 putative FPP binding hydrophobic cleft; other site 523794006052 dimer interface [polypeptide binding]; other site 523794006053 putative IPP diphosphate binding site; other site 523794006054 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 523794006055 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 523794006056 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 523794006057 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 523794006058 active site 523794006059 HIGH motif; other site 523794006060 dimer interface [polypeptide binding]; other site 523794006061 KMSKS motif; other site 523794006062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794006063 RNA binding surface [nucleotide binding]; other site 523794006064 Phosphotransferase enzyme family; Region: APH; pfam01636 523794006065 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 523794006066 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 523794006067 putative active site [active] 523794006068 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 523794006069 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 523794006070 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 523794006071 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 523794006072 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 523794006073 putative ADP-binding pocket [chemical binding]; other site 523794006074 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 523794006075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794006076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794006077 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 523794006078 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794006079 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 523794006080 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 523794006081 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 523794006082 putative metal binding site; other site 523794006083 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 523794006084 Substrate binding site; other site 523794006085 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 523794006086 metal-binding site 523794006087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 523794006088 active site 523794006089 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 523794006090 putative active site [active] 523794006091 putative metal binding site [ion binding]; other site 523794006092 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 523794006093 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 523794006094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 523794006095 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 523794006096 Walker A/P-loop; other site 523794006097 ATP binding site [chemical binding]; other site 523794006098 Q-loop/lid; other site 523794006099 ABC transporter signature motif; other site 523794006100 Walker B; other site 523794006101 D-loop; other site 523794006102 H-loop/switch region; other site 523794006103 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 523794006104 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 523794006105 DEAD-like helicases superfamily; Region: DEXDc; smart00487 523794006106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 523794006107 ATP binding site [chemical binding]; other site 523794006108 putative Mg++ binding site [ion binding]; other site 523794006109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 523794006110 nucleotide binding region [chemical binding]; other site 523794006111 ATP-binding site [chemical binding]; other site 523794006112 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 523794006113 Predicted peptidase [General function prediction only]; Region: COG4099 523794006114 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 523794006115 Uncharacterized protein, involved in the regulation of septum location [Cell envelope biogenesis, outer membrane]; Region: SpoVG; COG2088 523794006116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 523794006117 RNA binding surface [nucleotide binding]; other site 523794006118 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 523794006119 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 523794006120 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 523794006121 metal ion-dependent adhesion site (MIDAS); other site 523794006122 oxaloacetate decarboxylase; Provisional; Region: PRK12331 523794006123 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 523794006124 active site 523794006125 catalytic residues [active] 523794006126 metal binding site [ion binding]; metal-binding site 523794006127 homodimer binding site [polypeptide binding]; other site 523794006128 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 523794006129 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 523794006130 active site 523794006131 substrate-binding site [chemical binding]; other site 523794006132 metal-binding site [ion binding] 523794006133 ATP binding site [chemical binding]; other site 523794006134 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 523794006135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 523794006136 active site 523794006137 motif I; other site 523794006138 motif II; other site 523794006139 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523794006140 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523794006141 peptide binding site [polypeptide binding]; other site 523794006142 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523794006143 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523794006144 peptide binding site [polypeptide binding]; other site 523794006145 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523794006146 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523794006147 peptide binding site [polypeptide binding]; other site 523794006148 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 523794006149 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 523794006150 peptide binding site [polypeptide binding]; other site 523794006151 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 523794006152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794006153 Walker A/P-loop; other site 523794006154 ATP binding site [chemical binding]; other site 523794006155 Q-loop/lid; other site 523794006156 ABC transporter signature motif; other site 523794006157 Walker B; other site 523794006158 D-loop; other site 523794006159 H-loop/switch region; other site 523794006160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523794006161 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 523794006162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 523794006163 Walker A/P-loop; other site 523794006164 ATP binding site [chemical binding]; other site 523794006165 Q-loop/lid; other site 523794006166 ABC transporter signature motif; other site 523794006167 Walker B; other site 523794006168 D-loop; other site 523794006169 H-loop/switch region; other site 523794006170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 523794006171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 523794006172 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 523794006173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794006174 dimer interface [polypeptide binding]; other site 523794006175 conserved gate region; other site 523794006176 putative PBP binding loops; other site 523794006177 ABC-ATPase subunit interface; other site 523794006178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 523794006179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 523794006180 dimer interface [polypeptide binding]; other site 523794006181 conserved gate region; other site 523794006182 putative PBP binding loops; other site 523794006183 ABC-ATPase subunit interface; other site 523794006184 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 523794006185 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 523794006186 potential frameshift: common BLAST hit: gi|190150993|ref|YP_001969518.1| PTS system mannose-specific EIIAB component 523794006187 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 523794006188 active site 523794006189 phosphorylation site [posttranslational modification] 523794006190 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 523794006191 active pocket/dimerization site; other site 523794006192 active site 523794006193 phosphorylation site [posttranslational modification] 523794006194 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 523794006195 active site 523794006196 metal binding site [ion binding]; metal-binding site 523794006197 homotetramer interface [polypeptide binding]; other site 523794006198 DNA gyrase subunit A; Validated; Region: PRK05560 523794006199 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 523794006200 CAP-like domain; other site 523794006201 active site 523794006202 primary dimer interface [polypeptide binding]; other site 523794006203 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 523794006209 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 523794006210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 523794006211 Mg2+ binding site [ion binding]; other site 523794006212 G-X-G motif; other site 523794006213 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 523794006214 anchoring element; other site 523794006215 dimer interface [polypeptide binding]; other site 523794006216 ATP binding site [chemical binding]; other site 523794006217 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 523794006218 active site 523794006219 putative metal-binding site [ion binding]; other site 523794006220 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 523794006221 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 523794006222 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 523794006223 trmE is a tRNA modification GTPase; Region: trmE; cd04164 523794006224 G1 box; other site 523794006225 GTP/Mg2+ binding site [chemical binding]; other site 523794006226 Switch I region; other site 523794006227 G2 box; other site 523794006228 Switch II region; other site 523794006229 G3 box; other site 523794006230 G4 box; other site 523794006231 G5 box; other site 523794006232 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 523794006233 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 523794006234 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 523794006235 G-X-X-G motif; other site 523794006236 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 523794006237 RxxxH motif; other site 523794006238 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 523794006239 Haemolytic domain; Region: Haemolytic; pfam01809 523794006240 Ribonuclease P; Region: Ribonuclease_P; pfam00825 523794006241 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399