-- dump date   	20140619_131654
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1229758000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1229758000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1229758000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758000004	Walker A motif; other site
1229758000005	ATP binding site [chemical binding]; other site
1229758000006	Walker B motif; other site
1229758000007	arginine finger; other site
1229758000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1229758000009	DnaA box-binding interface [nucleotide binding]; other site
1229758000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1229758000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1229758000012	putative DNA binding surface [nucleotide binding]; other site
1229758000013	dimer interface [polypeptide binding]; other site
1229758000014	beta-clamp/clamp loader binding surface; other site
1229758000015	beta-clamp/translesion DNA polymerase binding surface; other site
1229758000016	S4 domain; Region: S4_2; pfam13275
1229758000017	recombination protein F; Reviewed; Region: recF; PRK00064
1229758000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1229758000019	Walker A/P-loop; other site
1229758000020	ATP binding site [chemical binding]; other site
1229758000021	Q-loop/lid; other site
1229758000022	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1229758000023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758000024	Mg2+ binding site [ion binding]; other site
1229758000025	G-X-G motif; other site
1229758000026	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
1229758000027	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229758000028	anchoring element; other site
1229758000029	dimer interface [polypeptide binding]; other site
1229758000030	ATP binding site [chemical binding]; other site
1229758000031	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1229758000032	active site
1229758000033	putative metal-binding site [ion binding]; other site
1229758000034	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229758000035	DNA gyrase subunit A; Validated; Region: PRK05560
1229758000036	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229758000037	CAP-like domain; other site
1229758000038	active site
1229758000039	primary dimer interface [polypeptide binding]; other site
1229758000040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000041	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000042	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758000046	PspC domain; Region: PspC; pfam04024
1229758000047	Immunity protein Imm3; Region: Imm3; pfam14425
1229758000048	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1229758000049	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1229758000050	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229758000051	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229758000052	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758000053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000054	non-specific DNA binding site [nucleotide binding]; other site
1229758000055	salt bridge; other site
1229758000056	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000057	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1229758000058	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1229758000059	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758000060	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1229758000061	Predicted membrane protein [Function unknown]; Region: COG1511
1229758000062	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229758000063	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1229758000064	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1229758000065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000066	putative substrate translocation pore; other site
1229758000067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758000068	Predicted membrane protein [Function unknown]; Region: COG2246
1229758000069	GtrA-like protein; Region: GtrA; pfam04138
1229758000070	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1229758000071	Protein of unknown function (DUF975); Region: DUF975; cl10504
1229758000072	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1229758000073	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1229758000074	active site
1229758000075	HIGH motif; other site
1229758000076	dimer interface [polypeptide binding]; other site
1229758000077	KMSKS motif; other site
1229758000078	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758000079	RNA binding surface [nucleotide binding]; other site
1229758000080	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1229758000081	D-lactate dehydrogenase; Validated; Region: PRK08605
1229758000082	homodimer interface [polypeptide binding]; other site
1229758000083	ligand binding site [chemical binding]; other site
1229758000084	NAD binding site [chemical binding]; other site
1229758000085	catalytic site [active]
1229758000086	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1229758000087	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229758000088	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1229758000089	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1229758000090	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1229758000091	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1229758000092	CoenzymeA binding site [chemical binding]; other site
1229758000093	subunit interaction site [polypeptide binding]; other site
1229758000094	PHB binding site; other site
1229758000095	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1229758000096	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1229758000097	substrate binding site [chemical binding]; other site
1229758000098	oxyanion hole (OAH) forming residues; other site
1229758000099	trimer interface [polypeptide binding]; other site
1229758000100	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1229758000101	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1229758000102	putative active site [active]
1229758000103	catalytic triad [active]
1229758000104	putative dimer interface [polypeptide binding]; other site
1229758000105	transaminase; Reviewed; Region: PRK08068
1229758000106	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758000107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758000108	homodimer interface [polypeptide binding]; other site
1229758000109	catalytic residue [active]
1229758000110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000111	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758000112	putative substrate translocation pore; other site
1229758000113	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1229758000114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758000115	active site
1229758000116	motif I; other site
1229758000117	motif II; other site
1229758000118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758000119	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
1229758000120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229758000121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758000122	Coenzyme A binding pocket [chemical binding]; other site
1229758000123	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1229758000124	Sulfatase; Region: Sulfatase; pfam00884
1229758000125	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758000126	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1229758000127	putative ADP-binding pocket [chemical binding]; other site
1229758000128	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1229758000129	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229758000130	DNA binding residues [nucleotide binding]
1229758000131	putative dimer interface [polypeptide binding]; other site
1229758000132	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229758000133	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229758000134	active site
1229758000135	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1229758000136	amphipathic channel; other site
1229758000137	Asn-Pro-Ala signature motifs; other site
1229758000138	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1229758000139	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758000140	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229758000141	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1229758000142	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1229758000143	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
1229758000144	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1229758000145	acyl-activating enzyme (AAE) consensus motif; other site
1229758000146	putative AMP binding site [chemical binding]; other site
1229758000147	putative active site [active]
1229758000148	putative CoA binding site [chemical binding]; other site
1229758000149	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1229758000150	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758000151	S-adenosylmethionine binding site [chemical binding]; other site
1229758000152	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229758000153	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1229758000154	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1229758000155	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1229758000156	putative catalytic cysteine [active]
1229758000157	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1229758000158	putative active site [active]
1229758000159	metal binding site [ion binding]; metal-binding site
1229758000160	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229758000161	Predicted membrane protein [Function unknown]; Region: COG1511
1229758000162	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1229758000163	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1229758000164	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229758000165	Transcriptional regulator; Region: Rrf2; pfam02082
1229758000166	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1229758000167	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229758000168	putative ion selectivity filter; other site
1229758000169	putative pore gating glutamate residue; other site
1229758000170	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229758000171	active site
1229758000172	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1229758000173	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758000174	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758000175	ABC transporter; Region: ABC_tran_2; pfam12848
1229758000176	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758000177	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229758000178	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229758000179	Ca binding site [ion binding]; other site
1229758000180	active site
1229758000181	catalytic site [active]
1229758000182	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
1229758000183	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1229758000184	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000185	putative substrate translocation pore; other site
1229758000186	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758000187	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758000188	DNA binding site [nucleotide binding]
1229758000189	domain linker motif; other site
1229758000190	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229758000191	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1229758000192	MucBP domain; Region: MucBP; pfam06458
1229758000193	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1229758000194	Helix-turn-helix domain; Region: HTH_18; pfam12833
1229758000195	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229758000196	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1229758000197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000198	putative substrate translocation pore; other site
1229758000199	VanW like protein; Region: VanW; pfam04294
1229758000200	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229758000201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758000202	active site
1229758000203	motif I; other site
1229758000204	motif II; other site
1229758000205	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1229758000206	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1229758000207	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229758000208	active site
1229758000209	phosphorylation site [posttranslational modification]
1229758000210	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1229758000211	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1229758000212	active site
1229758000213	P-loop; other site
1229758000214	phosphorylation site [posttranslational modification]
1229758000215	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1229758000216	active site
1229758000217	dimer interface [polypeptide binding]; other site
1229758000218	magnesium binding site [ion binding]; other site
1229758000219	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1229758000220	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1229758000221	AP (apurinic/apyrimidinic) site pocket; other site
1229758000222	DNA interaction; other site
1229758000223	Metal-binding active site; metal-binding site
1229758000224	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1229758000225	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1229758000226	intersubunit interface [polypeptide binding]; other site
1229758000227	active site
1229758000228	Zn2+ binding site [ion binding]; other site
1229758000229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000230	non-specific DNA binding site [nucleotide binding]; other site
1229758000231	salt bridge; other site
1229758000232	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000233	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758000234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000235	non-specific DNA binding site [nucleotide binding]; other site
1229758000236	salt bridge; other site
1229758000237	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000238	BioY family; Region: BioY; pfam02632
1229758000239	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1229758000240	CHY zinc finger; Region: zf-CHY; pfam05495
1229758000241	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1229758000242	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1229758000243	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1229758000244	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1229758000245	BioY family; Region: BioY; pfam02632
1229758000246	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1229758000247	AAA domain; Region: AAA_17; pfam13207
1229758000248	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1229758000249	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1229758000250	active site
1229758000251	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229758000252	dimer interface [polypeptide binding]; other site
1229758000253	substrate binding site [chemical binding]; other site
1229758000254	catalytic residues [active]
1229758000255	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1229758000256	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229758000257	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1229758000258	putative active site [active]
1229758000259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229758000260	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1229758000261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758000262	Walker A/P-loop; other site
1229758000263	ATP binding site [chemical binding]; other site
1229758000264	Q-loop/lid; other site
1229758000265	ABC transporter signature motif; other site
1229758000266	Walker B; other site
1229758000267	D-loop; other site
1229758000268	H-loop/switch region; other site
1229758000269	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229758000270	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229758000271	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1229758000272	Walker A/P-loop; other site
1229758000273	ATP binding site [chemical binding]; other site
1229758000274	Q-loop/lid; other site
1229758000275	ABC transporter signature motif; other site
1229758000276	Walker B; other site
1229758000277	D-loop; other site
1229758000278	H-loop/switch region; other site
1229758000279	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229758000280	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229758000281	Walker A/P-loop; other site
1229758000282	ATP binding site [chemical binding]; other site
1229758000283	Q-loop/lid; other site
1229758000284	ABC transporter signature motif; other site
1229758000285	Walker B; other site
1229758000286	D-loop; other site
1229758000287	H-loop/switch region; other site
1229758000288	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758000289	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758000290	substrate binding pocket [chemical binding]; other site
1229758000291	membrane-bound complex binding site; other site
1229758000292	hinge residues; other site
1229758000293	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229758000294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000295	dimer interface [polypeptide binding]; other site
1229758000296	conserved gate region; other site
1229758000297	putative PBP binding loops; other site
1229758000298	ABC-ATPase subunit interface; other site
1229758000299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000300	dimer interface [polypeptide binding]; other site
1229758000301	putative PBP binding loops; other site
1229758000302	ABC-ATPase subunit interface; other site
1229758000303	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1229758000304	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1229758000305	peptide binding site [polypeptide binding]; other site
1229758000306	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1229758000307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000308	dimer interface [polypeptide binding]; other site
1229758000309	conserved gate region; other site
1229758000310	putative PBP binding loops; other site
1229758000311	ABC-ATPase subunit interface; other site
1229758000312	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1229758000313	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1229758000314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000315	dimer interface [polypeptide binding]; other site
1229758000316	conserved gate region; other site
1229758000317	putative PBP binding loops; other site
1229758000318	ABC-ATPase subunit interface; other site
1229758000319	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1229758000320	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229758000321	Walker A/P-loop; other site
1229758000322	ATP binding site [chemical binding]; other site
1229758000323	Q-loop/lid; other site
1229758000324	ABC transporter signature motif; other site
1229758000325	Walker B; other site
1229758000326	D-loop; other site
1229758000327	H-loop/switch region; other site
1229758000328	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1229758000329	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1229758000330	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1229758000331	Walker A/P-loop; other site
1229758000332	ATP binding site [chemical binding]; other site
1229758000333	Q-loop/lid; other site
1229758000334	ABC transporter signature motif; other site
1229758000335	Walker B; other site
1229758000336	D-loop; other site
1229758000337	H-loop/switch region; other site
1229758000338	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1229758000339	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1229758000340	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1229758000341	active site
1229758000342	Zn binding site [ion binding]; other site
1229758000343	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1229758000344	Aspartase; Region: Aspartase; cd01357
1229758000345	active sites [active]
1229758000346	tetramer interface [polypeptide binding]; other site
1229758000347	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1229758000348	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229758000349	active site
1229758000350	dimer interface [polypeptide binding]; other site
1229758000351	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758000352	Coenzyme A binding pocket [chemical binding]; other site
1229758000353	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1229758000354	trimer interface [polypeptide binding]; other site
1229758000355	active site
1229758000356	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229758000357	nudix motif; other site
1229758000358	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229758000359	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758000360	Walker A motif; other site
1229758000361	ATP binding site [chemical binding]; other site
1229758000362	Walker B motif; other site
1229758000363	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1229758000364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000365	non-specific DNA binding site [nucleotide binding]; other site
1229758000366	salt bridge; other site
1229758000367	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758000369	short chain dehydrogenase; Provisional; Region: PRK12828
1229758000370	NAD(P) binding site [chemical binding]; other site
1229758000371	active site
1229758000372	short chain dehydrogenase; Validated; Region: PRK06182
1229758000373	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1229758000374	NADP binding site [chemical binding]; other site
1229758000375	active site
1229758000376	steroid binding site; other site
1229758000377	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758000378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000379	non-specific DNA binding site [nucleotide binding]; other site
1229758000380	salt bridge; other site
1229758000381	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000382	EDD domain protein, DegV family; Region: DegV; TIGR00762
1229758000383	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1229758000384	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1229758000385	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1229758000386	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1229758000387	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1229758000388	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1229758000389	effector binding site; other site
1229758000390	active site
1229758000391	Zn binding site [ion binding]; other site
1229758000392	glycine loop; other site
1229758000393	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1229758000394	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1229758000395	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1229758000396	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1229758000397	active site
1229758000398	zinc binding site [ion binding]; other site
1229758000399	Membrane transport protein; Region: Mem_trans; cl09117
1229758000400	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1229758000401	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1229758000402	G1 box; other site
1229758000403	putative GEF interaction site [polypeptide binding]; other site
1229758000404	GTP/Mg2+ binding site [chemical binding]; other site
1229758000405	Switch I region; other site
1229758000406	G2 box; other site
1229758000407	G3 box; other site
1229758000408	Switch II region; other site
1229758000409	G4 box; other site
1229758000410	G5 box; other site
1229758000411	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1229758000412	uracil transporter; Provisional; Region: PRK10720
1229758000413	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1229758000414	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1229758000415	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1229758000416	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1229758000417	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1229758000418	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1229758000419	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1229758000420	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1229758000421	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229758000422	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1229758000423	beta subunit interaction interface [polypeptide binding]; other site
1229758000424	Walker A motif; other site
1229758000425	ATP binding site [chemical binding]; other site
1229758000426	Walker B motif; other site
1229758000427	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229758000428	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1229758000429	core domain interface [polypeptide binding]; other site
1229758000430	delta subunit interface [polypeptide binding]; other site
1229758000431	epsilon subunit interface [polypeptide binding]; other site
1229758000432	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1229758000433	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1229758000434	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1229758000435	alpha subunit interaction interface [polypeptide binding]; other site
1229758000436	Walker A motif; other site
1229758000437	ATP binding site [chemical binding]; other site
1229758000438	Walker B motif; other site
1229758000439	inhibitor binding site; inhibition site
1229758000440	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1229758000441	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1229758000442	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1229758000443	gamma subunit interface [polypeptide binding]; other site
1229758000444	epsilon subunit interface [polypeptide binding]; other site
1229758000445	LBP interface [polypeptide binding]; other site
1229758000446	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1229758000447	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
1229758000448	High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646
1229758000449	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1229758000450	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1229758000451	Walker A/P-loop; other site
1229758000452	ATP binding site [chemical binding]; other site
1229758000453	Q-loop/lid; other site
1229758000454	ABC transporter signature motif; other site
1229758000455	Walker B; other site
1229758000456	D-loop; other site
1229758000457	H-loop/switch region; other site
1229758000458	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1229758000459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000460	dimer interface [polypeptide binding]; other site
1229758000461	conserved gate region; other site
1229758000462	putative PBP binding loops; other site
1229758000463	ABC-ATPase subunit interface; other site
1229758000464	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1229758000465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000466	dimer interface [polypeptide binding]; other site
1229758000467	conserved gate region; other site
1229758000468	putative PBP binding loops; other site
1229758000469	ABC-ATPase subunit interface; other site
1229758000470	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229758000471	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229758000472	active site
1229758000473	metal binding site [ion binding]; metal-binding site
1229758000474	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229758000475	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1229758000476	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758000477	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1229758000478	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1229758000479	putative active site [active]
1229758000480	putative FMN binding site [chemical binding]; other site
1229758000481	putative substrate binding site [chemical binding]; other site
1229758000482	putative catalytic residue [active]
1229758000483	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1229758000484	Part of AAA domain; Region: AAA_19; pfam13245
1229758000485	Family description; Region: UvrD_C_2; pfam13538
1229758000486	pantothenate kinase; Provisional; Region: PRK05439
1229758000487	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1229758000488	active site
1229758000489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000490	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758000491	putative substrate translocation pore; other site
1229758000492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000493	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1229758000494	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229758000495	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1229758000496	Phosphoglycerate kinase; Region: PGK; pfam00162
1229758000497	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1229758000498	substrate binding site [chemical binding]; other site
1229758000499	hinge regions; other site
1229758000500	ADP binding site [chemical binding]; other site
1229758000501	catalytic site [active]
1229758000502	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1229758000503	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229758000504	active site
1229758000505	HIGH motif; other site
1229758000506	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1229758000507	KMSKS motif; other site
1229758000508	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1229758000509	tRNA binding surface [nucleotide binding]; other site
1229758000510	anticodon binding site; other site
1229758000511	seryl-tRNA synthetase; Provisional; Region: PRK05431
1229758000512	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1229758000513	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1229758000514	dimer interface [polypeptide binding]; other site
1229758000515	active site
1229758000516	motif 1; other site
1229758000517	motif 2; other site
1229758000518	motif 3; other site
1229758000519	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1229758000520	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1229758000521	peptide chain release factor 2; Provisional; Region: PRK05589
1229758000522	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229758000523	RF-1 domain; Region: RF-1; pfam00472
1229758000524	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1229758000525	Clp amino terminal domain; Region: Clp_N; pfam02861
1229758000526	Clp amino terminal domain; Region: Clp_N; pfam02861
1229758000527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758000528	Walker A motif; other site
1229758000529	ATP binding site [chemical binding]; other site
1229758000530	Walker B motif; other site
1229758000531	arginine finger; other site
1229758000532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758000533	Walker A motif; other site
1229758000534	ATP binding site [chemical binding]; other site
1229758000535	Walker B motif; other site
1229758000536	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229758000537	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1229758000538	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1229758000539	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1229758000540	S17 interaction site [polypeptide binding]; other site
1229758000541	S8 interaction site; other site
1229758000542	16S rRNA interaction site [nucleotide binding]; other site
1229758000543	streptomycin interaction site [chemical binding]; other site
1229758000544	23S rRNA interaction site [nucleotide binding]; other site
1229758000545	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1229758000546	30S ribosomal protein S7; Validated; Region: PRK05302
1229758000547	elongation factor G; Reviewed; Region: PRK12739
1229758000548	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1229758000549	G1 box; other site
1229758000550	putative GEF interaction site [polypeptide binding]; other site
1229758000551	GTP/Mg2+ binding site [chemical binding]; other site
1229758000552	Switch I region; other site
1229758000553	G2 box; other site
1229758000554	G3 box; other site
1229758000555	Switch II region; other site
1229758000556	G4 box; other site
1229758000557	G5 box; other site
1229758000558	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1229758000559	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1229758000560	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1229758000561	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1229758000562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000563	putative substrate translocation pore; other site
1229758000564	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1229758000565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758000566	Walker A/P-loop; other site
1229758000567	ATP binding site [chemical binding]; other site
1229758000568	Q-loop/lid; other site
1229758000569	ABC transporter signature motif; other site
1229758000570	Walker B; other site
1229758000571	D-loop; other site
1229758000572	H-loop/switch region; other site
1229758000573	TOBE domain; Region: TOBE_2; pfam08402
1229758000574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000575	dimer interface [polypeptide binding]; other site
1229758000576	conserved gate region; other site
1229758000577	putative PBP binding loops; other site
1229758000578	ABC-ATPase subunit interface; other site
1229758000579	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1229758000580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758000581	dimer interface [polypeptide binding]; other site
1229758000582	conserved gate region; other site
1229758000583	putative PBP binding loops; other site
1229758000584	ABC-ATPase subunit interface; other site
1229758000585	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1229758000586	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1229758000587	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1229758000588	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1229758000589	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1229758000590	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1229758000591	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1229758000592	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1229758000593	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1229758000594	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1229758000595	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1229758000596	putative translocon binding site; other site
1229758000597	protein-rRNA interface [nucleotide binding]; other site
1229758000598	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1229758000599	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1229758000600	G-X-X-G motif; other site
1229758000601	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1229758000602	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1229758000603	23S rRNA interface [nucleotide binding]; other site
1229758000604	5S rRNA interface [nucleotide binding]; other site
1229758000605	putative antibiotic binding site [chemical binding]; other site
1229758000606	L25 interface [polypeptide binding]; other site
1229758000607	L27 interface [polypeptide binding]; other site
1229758000608	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1229758000609	putative translocon interaction site; other site
1229758000610	23S rRNA interface [nucleotide binding]; other site
1229758000611	signal recognition particle (SRP54) interaction site; other site
1229758000612	L23 interface [polypeptide binding]; other site
1229758000613	trigger factor interaction site; other site
1229758000614	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1229758000615	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1229758000616	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1229758000617	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1229758000618	RNA binding site [nucleotide binding]; other site
1229758000619	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1229758000620	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1229758000621	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1229758000622	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1229758000623	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1229758000624	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229758000625	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1229758000626	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1229758000627	5S rRNA interface [nucleotide binding]; other site
1229758000628	L27 interface [polypeptide binding]; other site
1229758000629	23S rRNA interface [nucleotide binding]; other site
1229758000630	L5 interface [polypeptide binding]; other site
1229758000631	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1229758000632	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1229758000633	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1229758000634	50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611
1229758000635	23S rRNA binding site - archaea [nucleotide binding]; other site
1229758000636	23S rRNA binding site - prokaryotes [nucleotide binding]; other site
1229758000637	5S rRNA binding site - archaea; other site
1229758000638	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1229758000639	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1229758000640	SecY translocase; Region: SecY; pfam00344
1229758000641	adenylate kinase; Reviewed; Region: adk; PRK00279
1229758000642	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1229758000643	AMP-binding site [chemical binding]; other site
1229758000644	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1229758000645	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1229758000646	rRNA binding site [nucleotide binding]; other site
1229758000647	predicted 30S ribosome binding site; other site
1229758000648	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1229758000649	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1229758000650	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1229758000651	30S ribosomal protein S11; Validated; Region: PRK05309
1229758000652	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1229758000653	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1229758000654	alphaNTD - beta interaction site [polypeptide binding]; other site
1229758000655	alphaNTD homodimer interface [polypeptide binding]; other site
1229758000656	alphaNTD - beta' interaction site [polypeptide binding]; other site
1229758000657	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1229758000658	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1229758000659	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229758000660	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229758000661	substrate binding pocket [chemical binding]; other site
1229758000662	chain length determination region; other site
1229758000663	substrate-Mg2+ binding site; other site
1229758000664	catalytic residues [active]
1229758000665	aspartate-rich region 1; other site
1229758000666	active site lid residues [active]
1229758000667	aspartate-rich region 2; other site
1229758000668	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1229758000669	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758000670	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1229758000671	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758000672	Walker A/P-loop; other site
1229758000673	ATP binding site [chemical binding]; other site
1229758000674	Q-loop/lid; other site
1229758000675	ABC transporter signature motif; other site
1229758000676	Walker B; other site
1229758000677	D-loop; other site
1229758000678	H-loop/switch region; other site
1229758000679	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1229758000680	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758000681	Walker A/P-loop; other site
1229758000682	ATP binding site [chemical binding]; other site
1229758000683	Q-loop/lid; other site
1229758000684	ABC transporter signature motif; other site
1229758000685	Walker B; other site
1229758000686	D-loop; other site
1229758000687	H-loop/switch region; other site
1229758000688	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1229758000689	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1229758000690	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1229758000691	dimerization interface 3.5A [polypeptide binding]; other site
1229758000692	active site
1229758000693	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1229758000694	23S rRNA interface [nucleotide binding]; other site
1229758000695	L3 interface [polypeptide binding]; other site
1229758000696	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1229758000697	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000698	non-specific DNA binding site [nucleotide binding]; other site
1229758000699	salt bridge; other site
1229758000700	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000702	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758000703	putative substrate translocation pore; other site
1229758000704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000705	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1229758000706	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1229758000707	HflX GTPase family; Region: HflX; cd01878
1229758000708	G1 box; other site
1229758000709	GTP/Mg2+ binding site [chemical binding]; other site
1229758000710	Switch I region; other site
1229758000711	G2 box; other site
1229758000712	G3 box; other site
1229758000713	Switch II region; other site
1229758000714	G4 box; other site
1229758000715	G5 box; other site
1229758000716	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758000717	catalytic core [active]
1229758000718	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1229758000719	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1229758000720	Domain of unknown function DUF21; Region: DUF21; pfam01595
1229758000721	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1229758000722	Transporter associated domain; Region: CorC_HlyC; smart01091
1229758000723	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1229758000724	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1229758000725	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1229758000726	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1229758000727	active site
1229758000728	dimer interface [polypeptide binding]; other site
1229758000729	catalytic residues [active]
1229758000730	effector binding site; other site
1229758000731	R2 peptide binding site; other site
1229758000732	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
1229758000733	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1229758000734	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1229758000735	dimer interface [polypeptide binding]; other site
1229758000736	putative radical transfer pathway; other site
1229758000737	diiron center [ion binding]; other site
1229758000738	tyrosyl radical; other site
1229758000739	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229758000740	active site
1229758000741	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758000742	catalytic core [active]
1229758000743	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758000744	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229758000745	DNA-binding site [nucleotide binding]; DNA binding site
1229758000746	RNA-binding motif; other site
1229758000747	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1229758000748	triosephosphate isomerase; Provisional; Region: PRK14565
1229758000749	substrate binding site [chemical binding]; other site
1229758000750	dimer interface [polypeptide binding]; other site
1229758000751	catalytic triad [active]
1229758000752	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1229758000753	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1229758000754	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1229758000755	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1229758000756	RPB1 interaction site [polypeptide binding]; other site
1229758000757	RPB10 interaction site [polypeptide binding]; other site
1229758000758	RPB11 interaction site [polypeptide binding]; other site
1229758000759	RPB3 interaction site [polypeptide binding]; other site
1229758000760	RPB12 interaction site [polypeptide binding]; other site
1229758000761	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1229758000762	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1229758000763	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1229758000764	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1229758000765	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1229758000766	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1229758000767	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1229758000768	DNA binding site [nucleotide binding]
1229758000769	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1229758000770	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1229758000771	active site
1229758000772	metal binding site [ion binding]; metal-binding site
1229758000773	dimerization interface [polypeptide binding]; other site
1229758000774	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1229758000775	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1229758000776	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229758000777	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1229758000778	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229758000779	enolase; Provisional; Region: eno; PRK00077
1229758000780	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1229758000781	dimer interface [polypeptide binding]; other site
1229758000782	metal binding site [ion binding]; metal-binding site
1229758000783	substrate binding pocket [chemical binding]; other site
1229758000784	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1229758000785	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1229758000786	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758000787	Zn2+ binding site [ion binding]; other site
1229758000788	Mg2+ binding site [ion binding]; other site
1229758000789	polyphosphate kinase; Provisional; Region: PRK05443
1229758000790	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1229758000791	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1229758000792	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1229758000793	putative domain interface [polypeptide binding]; other site
1229758000794	putative active site [active]
1229758000795	catalytic site [active]
1229758000796	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1229758000797	putative domain interface [polypeptide binding]; other site
1229758000798	putative active site [active]
1229758000799	catalytic site [active]
1229758000800	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1229758000801	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1229758000802	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1229758000803	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1229758000804	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1229758000805	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1229758000806	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758000807	ATP binding site [chemical binding]; other site
1229758000808	putative Mg++ binding site [ion binding]; other site
1229758000809	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758000810	nucleotide binding region [chemical binding]; other site
1229758000811	ATP-binding site [chemical binding]; other site
1229758000812	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1229758000813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758000814	active site
1229758000815	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1229758000816	30S subunit binding site; other site
1229758000817	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1229758000818	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758000819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758000820	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1229758000821	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
1229758000822	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1229758000823	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1229758000824	putative homodimer interface [polypeptide binding]; other site
1229758000825	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1229758000826	heterodimer interface [polypeptide binding]; other site
1229758000827	homodimer interface [polypeptide binding]; other site
1229758000828	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1229758000829	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1229758000830	23S rRNA interface [nucleotide binding]; other site
1229758000831	L7/L12 interface [polypeptide binding]; other site
1229758000832	putative thiostrepton binding site; other site
1229758000833	L25 interface [polypeptide binding]; other site
1229758000834	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1229758000835	mRNA/rRNA interface [nucleotide binding]; other site
1229758000836	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1229758000837	23S rRNA interface [nucleotide binding]; other site
1229758000838	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1229758000839	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1229758000840	peripheral dimer interface [polypeptide binding]; other site
1229758000841	core dimer interface [polypeptide binding]; other site
1229758000842	L10 interface [polypeptide binding]; other site
1229758000843	L11 interface [polypeptide binding]; other site
1229758000844	putative EF-Tu interaction site [polypeptide binding]; other site
1229758000845	putative EF-G interaction site [polypeptide binding]; other site
1229758000846	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1229758000847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758000848	S-adenosylmethionine binding site [chemical binding]; other site
1229758000849	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1229758000850	nucleoside/Zn binding site; other site
1229758000851	dimer interface [polypeptide binding]; other site
1229758000852	catalytic motif [active]
1229758000853	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758000854	Zn2+ binding site [ion binding]; other site
1229758000855	Mg2+ binding site [ion binding]; other site
1229758000856	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1229758000857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758000858	Walker A motif; other site
1229758000859	ATP binding site [chemical binding]; other site
1229758000860	Walker B motif; other site
1229758000861	recombination protein RecR; Reviewed; Region: recR; PRK00076
1229758000862	RecR protein; Region: RecR; pfam02132
1229758000863	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1229758000864	putative active site [active]
1229758000865	putative metal-binding site [ion binding]; other site
1229758000866	tetramer interface [polypeptide binding]; other site
1229758000867	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1229758000868	thymidylate kinase; Validated; Region: tmk; PRK00698
1229758000869	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1229758000870	TMP-binding site; other site
1229758000871	ATP-binding site [chemical binding]; other site
1229758000872	Protein of unknown function (DUF970); Region: DUF970; cl17525
1229758000873	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
1229758000874	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1229758000875	Predicted methyltransferases [General function prediction only]; Region: COG0313
1229758000876	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1229758000877	putative SAM binding site [chemical binding]; other site
1229758000878	putative homodimer interface [polypeptide binding]; other site
1229758000879	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1229758000880	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1229758000881	active site
1229758000882	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1229758000883	active site 2 [active]
1229758000884	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1229758000885	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1229758000886	NAD binding site [chemical binding]; other site
1229758000887	homodimer interface [polypeptide binding]; other site
1229758000888	active site
1229758000889	substrate binding site [chemical binding]; other site
1229758000890	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1229758000891	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1229758000892	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1229758000893	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1229758000894	Substrate-binding site [chemical binding]; other site
1229758000895	Substrate specificity [chemical binding]; other site
1229758000896	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1229758000897	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1229758000898	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1229758000899	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1229758000900	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1229758000901	active site
1229758000902	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1229758000903	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229758000904	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229758000905	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1229758000906	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1229758000907	ATP binding site [chemical binding]; other site
1229758000908	putative Mg++ binding site [ion binding]; other site
1229758000909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758000910	nucleotide binding region [chemical binding]; other site
1229758000911	ATP-binding site [chemical binding]; other site
1229758000912	EamA-like transporter family; Region: EamA; pfam00892
1229758000913	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1229758000914	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1229758000915	Sodium Bile acid symporter family; Region: SBF; pfam01758
1229758000916	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1229758000917	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1229758000918	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758000919	salt bridge; other site
1229758000920	non-specific DNA binding site [nucleotide binding]; other site
1229758000921	sequence-specific DNA binding site [nucleotide binding]; other site
1229758000922	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1229758000923	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1229758000924	Walker A/P-loop; other site
1229758000925	ATP binding site [chemical binding]; other site
1229758000926	Q-loop/lid; other site
1229758000927	ABC transporter signature motif; other site
1229758000928	Walker B; other site
1229758000929	D-loop; other site
1229758000930	H-loop/switch region; other site
1229758000931	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1229758000932	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1229758000933	FeS assembly protein SufD; Region: sufD; TIGR01981
1229758000934	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1229758000935	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1229758000936	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229758000937	catalytic residue [active]
1229758000938	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1229758000939	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1229758000940	trimerization site [polypeptide binding]; other site
1229758000941	active site
1229758000942	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1229758000943	FeS assembly protein SufB; Region: sufB; TIGR01980
1229758000944	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1229758000945	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1229758000946	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1229758000947	active site
1229758000948	catalytic residues [active]
1229758000949	metal binding site [ion binding]; metal-binding site
1229758000950	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1229758000951	tartrate dehydrogenase; Region: TTC; TIGR02089
1229758000952	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1229758000953	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1229758000954	substrate binding site [chemical binding]; other site
1229758000955	ligand binding site [chemical binding]; other site
1229758000956	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1229758000957	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1229758000958	substrate binding site [chemical binding]; other site
1229758000959	benzoate transport; Region: 2A0115; TIGR00895
1229758000960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758000961	putative substrate translocation pore; other site
1229758000962	High-affinity nickel-transport protein; Region: NicO; cl00964
1229758000963	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758000964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758000965	active site
1229758000966	phosphorylation site [posttranslational modification]
1229758000967	intermolecular recognition site; other site
1229758000968	dimerization interface [polypeptide binding]; other site
1229758000969	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758000970	DNA binding site [nucleotide binding]
1229758000971	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229758000972	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229758000973	dimer interface [polypeptide binding]; other site
1229758000974	phosphorylation site [posttranslational modification]
1229758000975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758000976	ATP binding site [chemical binding]; other site
1229758000977	Mg2+ binding site [ion binding]; other site
1229758000978	G-X-G motif; other site
1229758000979	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229758000980	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229758000981	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758000982	catalytic residues [active]
1229758000983	homoserine O-succinyltransferase; Region: metA; TIGR01001
1229758000984	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229758000985	conserved cys residue [active]
1229758000986	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1229758000987	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1229758000988	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229758000989	catalytic residue [active]
1229758000990	cystathionine beta-lyase; Provisional; Region: PRK08064
1229758000991	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229758000992	homodimer interface [polypeptide binding]; other site
1229758000993	substrate-cofactor binding pocket; other site
1229758000994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758000995	catalytic residue [active]
1229758000996	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1229758000997	substrate binding site [chemical binding]; other site
1229758000998	THF binding site; other site
1229758000999	zinc-binding site [ion binding]; other site
1229758001000	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229758001001	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1229758001002	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1229758001003	substrate binding site [chemical binding]; other site
1229758001004	THF binding site; other site
1229758001005	zinc-binding site [ion binding]; other site
1229758001006	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1229758001007	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229758001008	homodimer interface [polypeptide binding]; other site
1229758001009	substrate-cofactor binding pocket; other site
1229758001010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758001011	catalytic residue [active]
1229758001012	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1229758001013	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1229758001014	peptide binding site [polypeptide binding]; other site
1229758001015	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1229758001016	Peptidase C26; Region: Peptidase_C26; pfam07722
1229758001017	catalytic triad [active]
1229758001018	Amino acid permease; Region: AA_permease_2; pfam13520
1229758001019	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1229758001020	catalytic triad [active]
1229758001021	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1229758001022	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758001023	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1229758001024	thymidine kinase; Provisional; Region: PRK04296
1229758001025	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1229758001026	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1229758001027	RF-1 domain; Region: RF-1; pfam00472
1229758001028	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1229758001029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758001030	S-adenosylmethionine binding site [chemical binding]; other site
1229758001031	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1229758001032	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1229758001033	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1229758001034	dimerization domain swap beta strand [polypeptide binding]; other site
1229758001035	regulatory protein interface [polypeptide binding]; other site
1229758001036	active site
1229758001037	regulatory phosphorylation site [posttranslational modification]; other site
1229758001038	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1229758001039	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1229758001040	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1229758001041	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1229758001042	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1229758001043	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1229758001044	Glycoprotease family; Region: Peptidase_M22; pfam00814
1229758001045	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1229758001046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758001047	Coenzyme A binding pocket [chemical binding]; other site
1229758001048	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1229758001049	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758001050	Coenzyme A binding pocket [chemical binding]; other site
1229758001051	Domain of unknown function DUF87; Region: DUF87; pfam01935
1229758001052	AAA-like domain; Region: AAA_10; pfam12846
1229758001053	UGMP family protein; Validated; Region: PRK09604
1229758001054	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1229758001055	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1229758001056	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1229758001057	CoA binding domain; Region: CoA_binding; pfam02629
1229758001058	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1229758001059	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1229758001060	Predicted membrane protein [Function unknown]; Region: COG2246
1229758001061	GtrA-like protein; Region: GtrA; pfam04138
1229758001062	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1229758001063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758001064	active site
1229758001065	motif I; other site
1229758001066	motif II; other site
1229758001067	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1229758001068	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1229758001069	dimer interface [polypeptide binding]; other site
1229758001070	FMN binding site [chemical binding]; other site
1229758001071	NADPH bind site [chemical binding]; other site
1229758001072	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1229758001073	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1229758001074	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1229758001075	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1229758001076	active pocket/dimerization site; other site
1229758001077	active site
1229758001078	phosphorylation site [posttranslational modification]
1229758001079	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1229758001080	active site
1229758001081	phosphorylation site [posttranslational modification]
1229758001082	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1229758001083	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1229758001084	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1229758001085	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1229758001086	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1229758001087	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229758001088	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1229758001089	oligomerisation interface [polypeptide binding]; other site
1229758001090	mobile loop; other site
1229758001091	roof hairpin; other site
1229758001092	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1229758001093	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1229758001094	ring oligomerisation interface [polypeptide binding]; other site
1229758001095	ATP/Mg binding site [chemical binding]; other site
1229758001096	stacking interactions; other site
1229758001097	hinge regions; other site
1229758001098	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229758001099	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1229758001100	trimer interface [polypeptide binding]; other site
1229758001101	active site
1229758001102	G bulge; other site
1229758001103	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1229758001104	Predicted membrane protein [Function unknown]; Region: COG2323
1229758001105	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1229758001106	UbiA prenyltransferase family; Region: UbiA; pfam01040
1229758001107	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1229758001108	ACT domain; Region: ACT_4; pfam13291
1229758001109	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1229758001110	putative active site [active]
1229758001111	catalytic residue [active]
1229758001112	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1229758001113	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1229758001114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758001115	ATP binding site [chemical binding]; other site
1229758001116	putative Mg++ binding site [ion binding]; other site
1229758001117	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758001118	nucleotide binding region [chemical binding]; other site
1229758001119	ATP-binding site [chemical binding]; other site
1229758001120	TRCF domain; Region: TRCF; pfam03461
1229758001121	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758001122	RNA binding surface [nucleotide binding]; other site
1229758001123	Septum formation initiator; Region: DivIC; pfam04977
1229758001124	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1229758001125	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1229758001126	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1229758001127	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758001128	active site
1229758001129	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1229758001130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758001131	Walker A motif; other site
1229758001132	ATP binding site [chemical binding]; other site
1229758001133	Walker B motif; other site
1229758001134	arginine finger; other site
1229758001135	Peptidase family M41; Region: Peptidase_M41; pfam01434
1229758001136	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1229758001137	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1229758001138	domain crossover interface; other site
1229758001139	dimerization interface [polypeptide binding]; other site
1229758001140	redox-dependent activation switch; other site
1229758001141	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1229758001142	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1229758001143	dimer interface [polypeptide binding]; other site
1229758001144	putative anticodon binding site; other site
1229758001145	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1229758001146	motif 1; other site
1229758001147	active site
1229758001148	motif 2; other site
1229758001149	motif 3; other site
1229758001150	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1229758001151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
1229758001152	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
1229758001153	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758001154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758001155	non-specific DNA binding site [nucleotide binding]; other site
1229758001156	salt bridge; other site
1229758001157	sequence-specific DNA binding site [nucleotide binding]; other site
1229758001158	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1229758001159	GIY-YIG motif/motif A; other site
1229758001160	active site
1229758001161	catalytic site [active]
1229758001162	metal binding site [ion binding]; metal-binding site
1229758001163	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1229758001164	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1229758001165	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229758001166	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1229758001167	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229758001168	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229758001169	Walker A/P-loop; other site
1229758001170	ATP binding site [chemical binding]; other site
1229758001171	Q-loop/lid; other site
1229758001172	ABC transporter signature motif; other site
1229758001173	Walker B; other site
1229758001174	D-loop; other site
1229758001175	H-loop/switch region; other site
1229758001176	FtsX-like permease family; Region: FtsX; pfam02687
1229758001177	potential frameshift: common BLAST hit: gi|300172748|ref|YP_003771913.1| putative substrate-binding protein
1229758001178	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229758001179	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229758001180	Walker A/P-loop; other site
1229758001181	ATP binding site [chemical binding]; other site
1229758001182	Q-loop/lid; other site
1229758001183	ABC transporter signature motif; other site
1229758001184	Walker B; other site
1229758001185	D-loop; other site
1229758001186	H-loop/switch region; other site
1229758001187	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1229758001188	LytTr DNA-binding domain; Region: LytTR; smart00850
1229758001189	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1229758001190	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1229758001191	active site
1229758001192	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1229758001193	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229758001194	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229758001195	nudix motif; other site
1229758001196	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
1229758001197	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1229758001198	active site
1229758001199	putative interdomain interaction site [polypeptide binding]; other site
1229758001200	putative metal-binding site [ion binding]; other site
1229758001201	putative nucleotide binding site [chemical binding]; other site
1229758001202	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1229758001203	domain I; other site
1229758001204	DNA binding groove [nucleotide binding]
1229758001205	phosphate binding site [ion binding]; other site
1229758001206	domain II; other site
1229758001207	domain III; other site
1229758001208	nucleotide binding site [chemical binding]; other site
1229758001209	catalytic site [active]
1229758001210	domain IV; other site
1229758001211	benzoate transport; Region: 2A0115; TIGR00895
1229758001212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758001213	putative substrate translocation pore; other site
1229758001214	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229758001215	nudix motif; other site
1229758001216	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1229758001217	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1229758001218	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1229758001219	Cobalt transport protein; Region: CbiQ; cl00463
1229758001220	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229758001221	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758001222	Walker A/P-loop; other site
1229758001223	ATP binding site [chemical binding]; other site
1229758001224	Q-loop/lid; other site
1229758001225	ABC transporter signature motif; other site
1229758001226	Walker B; other site
1229758001227	D-loop; other site
1229758001228	H-loop/switch region; other site
1229758001229	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229758001230	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758001231	Walker A/P-loop; other site
1229758001232	ATP binding site [chemical binding]; other site
1229758001233	Q-loop/lid; other site
1229758001234	ABC transporter signature motif; other site
1229758001235	Walker B; other site
1229758001236	D-loop; other site
1229758001237	H-loop/switch region; other site
1229758001238	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1229758001239	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1229758001240	tetramer interfaces [polypeptide binding]; other site
1229758001241	binuclear metal-binding site [ion binding]; other site
1229758001242	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1229758001243	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1229758001244	active site
1229758001245	dimer interface [polypeptide binding]; other site
1229758001246	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229758001247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229758001248	DNA-binding site [nucleotide binding]; DNA binding site
1229758001249	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1229758001250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758001251	dimer interface [polypeptide binding]; other site
1229758001252	conserved gate region; other site
1229758001253	ABC-ATPase subunit interface; other site
1229758001254	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1229758001255	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1229758001256	Walker A/P-loop; other site
1229758001257	ATP binding site [chemical binding]; other site
1229758001258	Q-loop/lid; other site
1229758001259	ABC transporter signature motif; other site
1229758001260	Walker B; other site
1229758001261	D-loop; other site
1229758001262	H-loop/switch region; other site
1229758001263	NIL domain; Region: NIL; pfam09383
1229758001264	hypothetical protein; Provisional; Region: PRK06446
1229758001265	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
1229758001266	metal binding site [ion binding]; metal-binding site
1229758001267	dimer interface [polypeptide binding]; other site
1229758001268	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229758001269	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229758001270	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1229758001271	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1229758001272	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1229758001273	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1229758001274	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1229758001275	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758001276	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1229758001277	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229758001278	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1229758001279	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1229758001280	metal binding site 2 [ion binding]; metal-binding site
1229758001281	putative DNA binding helix; other site
1229758001282	metal binding site 1 [ion binding]; metal-binding site
1229758001283	dimer interface [polypeptide binding]; other site
1229758001284	structural Zn2+ binding site [ion binding]; other site
1229758001285	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1229758001286	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1229758001287	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1229758001288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1229758001289	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1229758001290	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1229758001291	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1229758001292	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1229758001293	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1229758001294	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1229758001295	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1229758001296	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1229758001297	phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655
1229758001298	phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751
1229758001299	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1229758001300	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229758001301	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1229758001302	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
1229758001303	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1229758001304	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1229758001305	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1229758001306	elongation factor P; Validated; Region: PRK00529
1229758001307	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1229758001308	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1229758001309	RNA binding site [nucleotide binding]; other site
1229758001310	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1229758001311	RNA binding site [nucleotide binding]; other site
1229758001312	Asp23 family; Region: Asp23; pfam03780
1229758001313	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1229758001314	putative RNA binding site [nucleotide binding]; other site
1229758001315	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1229758001316	active site
1229758001317	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1229758001318	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1229758001319	putative active site [active]
1229758001320	putative metal binding site [ion binding]; other site
1229758001321	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1229758001322	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1229758001323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758001324	S-adenosylmethionine binding site [chemical binding]; other site
1229758001325	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1229758001326	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1229758001327	intersubunit interface [polypeptide binding]; other site
1229758001328	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229758001329	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1229758001330	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1229758001331	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1229758001332	putative PBP binding regions; other site
1229758001333	ABC-ATPase subunit  interface; other site
1229758001334	pur operon repressor; Provisional; Region: PRK09213
1229758001335	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1229758001336	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758001337	active site
1229758001338	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1229758001339	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1229758001340	Substrate binding site; other site
1229758001341	Mg++ binding site; other site
1229758001342	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1229758001343	active site
1229758001344	substrate binding site [chemical binding]; other site
1229758001345	CoA binding site [chemical binding]; other site
1229758001346	SLBB domain; Region: SLBB; pfam10531
1229758001347	comEA protein; Region: comE; TIGR01259
1229758001348	Helix-hairpin-helix motif; Region: HHH; pfam00633
1229758001349	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1229758001350	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1229758001351	Competence protein; Region: Competence; pfam03772
1229758001352	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1229758001353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229758001354	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1229758001355	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1229758001356	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1229758001357	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1229758001358	16S/18S rRNA binding site [nucleotide binding]; other site
1229758001359	S13e-L30e interaction site [polypeptide binding]; other site
1229758001360	25S rRNA binding site [nucleotide binding]; other site
1229758001361	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1229758001362	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1229758001363	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1229758001364	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1229758001365	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1229758001366	GatB domain; Region: GatB_Yqey; smart00845
1229758001367	putative lipid kinase; Reviewed; Region: PRK13055
1229758001368	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1229758001369	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1229758001370	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1229758001371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229758001372	CTP synthetase; Validated; Region: pyrG; PRK05380
1229758001373	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1229758001374	Catalytic site [active]
1229758001375	active site
1229758001376	UTP binding site [chemical binding]; other site
1229758001377	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1229758001378	active site
1229758001379	putative oxyanion hole; other site
1229758001380	catalytic triad [active]
1229758001381	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1229758001382	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1229758001383	GIY-YIG motif/motif A; other site
1229758001384	active site
1229758001385	catalytic site [active]
1229758001386	putative DNA binding site [nucleotide binding]; other site
1229758001387	metal binding site [ion binding]; metal-binding site
1229758001388	UvrB/uvrC motif; Region: UVR; pfam02151
1229758001389	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1229758001390	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1229758001391	DNA binding site [nucleotide binding]
1229758001392	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1229758001393	GTP1/OBG; Region: GTP1_OBG; pfam01018
1229758001394	Obg GTPase; Region: Obg; cd01898
1229758001395	G1 box; other site
1229758001396	GTP/Mg2+ binding site [chemical binding]; other site
1229758001397	Switch I region; other site
1229758001398	G2 box; other site
1229758001399	G3 box; other site
1229758001400	Switch II region; other site
1229758001401	G4 box; other site
1229758001402	G5 box; other site
1229758001403	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1229758001404	acetolactate synthase; Reviewed; Region: PRK08617
1229758001405	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229758001406	PYR/PP interface [polypeptide binding]; other site
1229758001407	dimer interface [polypeptide binding]; other site
1229758001408	TPP binding site [chemical binding]; other site
1229758001409	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229758001410	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1229758001411	TPP-binding site [chemical binding]; other site
1229758001412	potential frameshift: common BLAST hit: gi|376260482|ref|YP_005147202.1| DNA modification methylase
1229758001413	Terminase small subunit; Region: Terminase_2; cl01513
1229758001414	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229758001415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758001416	Coenzyme A binding pocket [chemical binding]; other site
1229758001417	thymidylate synthase; Region: thym_sym; TIGR03284
1229758001418	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1229758001419	dimerization interface [polypeptide binding]; other site
1229758001420	active site
1229758001421	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1229758001422	catalytic motif [active]
1229758001423	Zn binding site [ion binding]; other site
1229758001424	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1229758001425	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1229758001426	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1229758001427	homodimer interface [polypeptide binding]; other site
1229758001428	NADP binding site [chemical binding]; other site
1229758001429	substrate binding site [chemical binding]; other site
1229758001430	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229758001431	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229758001432	DNA-binding site [nucleotide binding]; DNA binding site
1229758001433	TrkA-C domain; Region: TrkA_C; pfam02080
1229758001434	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1229758001435	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1229758001436	Walker A/P-loop; other site
1229758001437	ATP binding site [chemical binding]; other site
1229758001438	Q-loop/lid; other site
1229758001439	ABC transporter signature motif; other site
1229758001440	Walker B; other site
1229758001441	D-loop; other site
1229758001442	H-loop/switch region; other site
1229758001443	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1229758001444	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1229758001445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758001446	dimer interface [polypeptide binding]; other site
1229758001447	conserved gate region; other site
1229758001448	putative PBP binding loops; other site
1229758001449	ABC-ATPase subunit interface; other site
1229758001450	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1229758001451	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229758001452	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1229758001453	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1229758001454	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1229758001455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758001456	Walker A/P-loop; other site
1229758001457	ATP binding site [chemical binding]; other site
1229758001458	Q-loop/lid; other site
1229758001459	ABC transporter signature motif; other site
1229758001460	Walker B; other site
1229758001461	D-loop; other site
1229758001462	H-loop/switch region; other site
1229758001463	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1229758001464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758001465	non-specific DNA binding site [nucleotide binding]; other site
1229758001466	salt bridge; other site
1229758001467	sequence-specific DNA binding site [nucleotide binding]; other site
1229758001468	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1229758001469	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1229758001470	active site
1229758001471	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1229758001472	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229758001473	DNA binding residues [nucleotide binding]
1229758001474	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
1229758001475	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1229758001476	Domain of unknown function (DUF955); Region: DUF955; cl01076
1229758001477	Predicted flavoprotein [General function prediction only]; Region: COG0431
1229758001478	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229758001479	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1229758001480	Y-family of DNA polymerases; Region: PolY; cl12025
1229758001481	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1229758001482	generic binding surface II; other site
1229758001483	ssDNA binding site; other site
1229758001484	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758001485	ATP binding site [chemical binding]; other site
1229758001486	putative Mg++ binding site [ion binding]; other site
1229758001487	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758001488	nucleotide binding region [chemical binding]; other site
1229758001489	ATP-binding site [chemical binding]; other site
1229758001490	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1229758001491	MutS domain I; Region: MutS_I; pfam01624
1229758001492	MutS domain II; Region: MutS_II; pfam05188
1229758001493	MutS domain III; Region: MutS_III; pfam05192
1229758001494	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1229758001495	Walker A/P-loop; other site
1229758001496	ATP binding site [chemical binding]; other site
1229758001497	Q-loop/lid; other site
1229758001498	ABC transporter signature motif; other site
1229758001499	Walker B; other site
1229758001500	D-loop; other site
1229758001501	H-loop/switch region; other site
1229758001502	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1229758001503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758001504	ATP binding site [chemical binding]; other site
1229758001505	Mg2+ binding site [ion binding]; other site
1229758001506	G-X-G motif; other site
1229758001507	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1229758001508	ATP binding site [chemical binding]; other site
1229758001509	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1229758001510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1229758001511	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1229758001512	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1229758001513	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1229758001514	active site
1229758001515	multimer interface [polypeptide binding]; other site
1229758001516	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1229758001517	FAD binding domain; Region: FAD_binding_4; pfam01565
1229758001518	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1229758001519	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1229758001520	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1229758001521	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1229758001522	YbbR-like protein; Region: YbbR; pfam07949
1229758001523	YbbR-like protein; Region: YbbR; pfam07949
1229758001524	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1229758001525	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1229758001526	active site
1229758001527	substrate binding site [chemical binding]; other site
1229758001528	metal binding site [ion binding]; metal-binding site
1229758001529	ribonuclease III; Reviewed; Region: rnc; PRK00102
1229758001530	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1229758001531	dimerization interface [polypeptide binding]; other site
1229758001532	active site
1229758001533	metal binding site [ion binding]; metal-binding site
1229758001534	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1229758001535	dsRNA binding site [nucleotide binding]; other site
1229758001536	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229758001537	AAA domain; Region: AAA_23; pfam13476
1229758001538	Walker A/P-loop; other site
1229758001539	ATP binding site [chemical binding]; other site
1229758001540	Q-loop/lid; other site
1229758001541	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1229758001542	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1229758001543	ABC transporter signature motif; other site
1229758001544	Walker B; other site
1229758001545	D-loop; other site
1229758001546	H-loop/switch region; other site
1229758001547	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1229758001548	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1229758001549	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229758001550	P loop; other site
1229758001551	GTP binding site [chemical binding]; other site
1229758001552	putative DNA-binding protein; Validated; Region: PRK00118
1229758001553	signal recognition particle protein; Provisional; Region: PRK10867
1229758001554	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1229758001555	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1229758001556	P loop; other site
1229758001557	GTP binding site [chemical binding]; other site
1229758001558	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1229758001559	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1229758001560	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229758001561	active site
1229758001562	motif I; other site
1229758001563	motif II; other site
1229758001564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758001565	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1229758001566	beta-galactosidase; Region: BGL; TIGR03356
1229758001567	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
1229758001568	active site
1229758001569	P-loop; other site
1229758001570	phosphorylation site [posttranslational modification]
1229758001571	potential frameshift: common BLAST hit: gi|300172920|ref|YP_003772085.1| BglG family transcriptional regulator
1229758001572	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1229758001573	methionine cluster; other site
1229758001574	active site
1229758001575	phosphorylation site [posttranslational modification]
1229758001576	metal binding site [ion binding]; metal-binding site
1229758001577	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1229758001578	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1229758001579	histidinol-phosphatase; Reviewed; Region: PRK08123
1229758001580	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1229758001581	active site
1229758001582	dimer interface [polypeptide binding]; other site
1229758001583	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1229758001584	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1229758001585	motif 1; other site
1229758001586	dimer interface [polypeptide binding]; other site
1229758001587	active site
1229758001588	motif 2; other site
1229758001589	motif 3; other site
1229758001590	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1229758001591	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1229758001592	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1229758001593	histidinol dehydrogenase; Region: hisD; TIGR00069
1229758001594	NAD binding site [chemical binding]; other site
1229758001595	dimerization interface [polypeptide binding]; other site
1229758001596	product binding site; other site
1229758001597	substrate binding site [chemical binding]; other site
1229758001598	zinc binding site [ion binding]; other site
1229758001599	catalytic residues [active]
1229758001600	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1229758001601	putative active site pocket [active]
1229758001602	4-fold oligomerization interface [polypeptide binding]; other site
1229758001603	metal binding residues [ion binding]; metal-binding site
1229758001604	3-fold/trimer interface [polypeptide binding]; other site
1229758001605	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1229758001606	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1229758001607	putative active site [active]
1229758001608	oxyanion strand; other site
1229758001609	catalytic triad [active]
1229758001610	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1229758001611	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1229758001612	catalytic residues [active]
1229758001613	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1229758001614	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1229758001615	substrate binding site [chemical binding]; other site
1229758001616	glutamase interaction surface [polypeptide binding]; other site
1229758001617	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1229758001618	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1229758001619	metal binding site [ion binding]; metal-binding site
1229758001620	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1229758001621	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758001622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758001623	homodimer interface [polypeptide binding]; other site
1229758001624	catalytic residue [active]
1229758001625	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1229758001626	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1229758001627	GDP-binding site [chemical binding]; other site
1229758001628	ACT binding site; other site
1229758001629	IMP binding site; other site
1229758001630	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1229758001631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758001632	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758001633	Walker A motif; other site
1229758001634	ATP binding site [chemical binding]; other site
1229758001635	Walker B motif; other site
1229758001636	arginine finger; other site
1229758001637	UvrB/uvrC motif; Region: UVR; pfam02151
1229758001638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758001639	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758001640	Walker A motif; other site
1229758001641	ATP binding site [chemical binding]; other site
1229758001642	Walker B motif; other site
1229758001643	arginine finger; other site
1229758001644	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1229758001645	rod shape-determining protein MreB; Provisional; Region: PRK13927
1229758001646	MreB and similar proteins; Region: MreB_like; cd10225
1229758001647	nucleotide binding site [chemical binding]; other site
1229758001648	Mg binding site [ion binding]; other site
1229758001649	putative protofilament interaction site [polypeptide binding]; other site
1229758001650	RodZ interaction site [polypeptide binding]; other site
1229758001651	rod shape-determining protein MreC; Provisional; Region: PRK13922
1229758001652	rod shape-determining protein MreC; Region: MreC; pfam04085
1229758001653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758001654	dimer interface [polypeptide binding]; other site
1229758001655	conserved gate region; other site
1229758001656	putative PBP binding loops; other site
1229758001657	ABC-ATPase subunit interface; other site
1229758001658	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229758001659	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758001660	Walker A/P-loop; other site
1229758001661	ATP binding site [chemical binding]; other site
1229758001662	Q-loop/lid; other site
1229758001663	ABC transporter signature motif; other site
1229758001664	Walker B; other site
1229758001665	D-loop; other site
1229758001666	H-loop/switch region; other site
1229758001667	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758001668	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758001669	substrate binding pocket [chemical binding]; other site
1229758001670	membrane-bound complex binding site; other site
1229758001671	hinge residues; other site
1229758001672	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1229758001673	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1229758001674	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1229758001675	putative active site [active]
1229758001676	catalytic site [active]
1229758001677	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1229758001678	putative active site [active]
1229758001679	catalytic site [active]
1229758001680	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1229758001681	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1229758001682	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1229758001683	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1229758001684	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1229758001685	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1229758001686	Helix-turn-helix domain; Region: HTH_25; pfam13413
1229758001687	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1229758001688	recombinase A; Provisional; Region: recA; PRK09354
1229758001689	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1229758001690	hexamer interface [polypeptide binding]; other site
1229758001691	Walker A motif; other site
1229758001692	ATP binding site [chemical binding]; other site
1229758001693	Walker B motif; other site
1229758001694	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758001695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758001696	active site
1229758001697	phosphorylation site [posttranslational modification]
1229758001698	intermolecular recognition site; other site
1229758001699	dimerization interface [polypeptide binding]; other site
1229758001700	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758001701	DNA binding site [nucleotide binding]
1229758001702	PBP superfamily domain; Region: PBP_like_2; cl17296
1229758001703	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1229758001704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229758001705	dimer interface [polypeptide binding]; other site
1229758001706	phosphorylation site [posttranslational modification]
1229758001707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758001708	ATP binding site [chemical binding]; other site
1229758001709	Mg2+ binding site [ion binding]; other site
1229758001710	G-X-G motif; other site
1229758001711	PBP superfamily domain; Region: PBP_like_2; cl17296
1229758001712	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1229758001713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758001714	dimer interface [polypeptide binding]; other site
1229758001715	conserved gate region; other site
1229758001716	putative PBP binding loops; other site
1229758001717	ABC-ATPase subunit interface; other site
1229758001718	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1229758001719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758001720	dimer interface [polypeptide binding]; other site
1229758001721	conserved gate region; other site
1229758001722	putative PBP binding loops; other site
1229758001723	ABC-ATPase subunit interface; other site
1229758001724	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1229758001725	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1229758001726	Walker A/P-loop; other site
1229758001727	ATP binding site [chemical binding]; other site
1229758001728	Q-loop/lid; other site
1229758001729	ABC transporter signature motif; other site
1229758001730	Walker B; other site
1229758001731	D-loop; other site
1229758001732	H-loop/switch region; other site
1229758001733	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1229758001734	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1229758001735	Walker A/P-loop; other site
1229758001736	ATP binding site [chemical binding]; other site
1229758001737	Q-loop/lid; other site
1229758001738	ABC transporter signature motif; other site
1229758001739	Walker B; other site
1229758001740	D-loop; other site
1229758001741	H-loop/switch region; other site
1229758001742	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1229758001743	PhoU domain; Region: PhoU; pfam01895
1229758001744	PhoU domain; Region: PhoU; pfam01895
1229758001745	Membrane protein of unknown function; Region: DUF360; pfam04020
1229758001746	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1229758001747	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1229758001748	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1229758001749	Hpr binding site; other site
1229758001750	active site
1229758001751	homohexamer subunit interaction site [polypeptide binding]; other site
1229758001752	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1229758001753	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1229758001754	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1229758001755	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1229758001756	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1229758001757	active site
1229758001758	tetramer interface; other site
1229758001759	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1229758001760	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758001761	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758001762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758001763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758001764	putative substrate translocation pore; other site
1229758001765	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
1229758001766	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
1229758001767	active site
1229758001768	homodimer interface [polypeptide binding]; other site
1229758001769	catalytic site [active]
1229758001770	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1229758001771	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1229758001772	active site
1229758001773	substrate binding site [chemical binding]; other site
1229758001774	metal binding site [ion binding]; metal-binding site
1229758001775	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1229758001776	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1229758001777	active site
1229758001778	DNA polymerase IV; Validated; Region: PRK02406
1229758001779	DNA binding site [nucleotide binding]
1229758001780	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1229758001781	DHH family; Region: DHH; pfam01368
1229758001782	DHHA1 domain; Region: DHHA1; pfam02272
1229758001783	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229758001784	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229758001785	ATP binding site [chemical binding]; other site
1229758001786	Mg++ binding site [ion binding]; other site
1229758001787	motif III; other site
1229758001788	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758001789	nucleotide binding region [chemical binding]; other site
1229758001790	ATP-binding site [chemical binding]; other site
1229758001791	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1229758001792	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1229758001793	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1229758001794	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1229758001795	acyl-activating enzyme (AAE) consensus motif; other site
1229758001796	AMP binding site [chemical binding]; other site
1229758001797	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1229758001798	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1229758001799	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1229758001800	DltD N-terminal region; Region: DltD_N; pfam04915
1229758001801	DltD central region; Region: DltD_M; pfam04918
1229758001802	DltD C-terminal region; Region: DltD_C; pfam04914
1229758001803	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1229758001804	glutamate racemase; Provisional; Region: PRK00865
1229758001805	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1229758001806	active site
1229758001807	dimerization interface [polypeptide binding]; other site
1229758001808	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1229758001809	active site
1229758001810	metal binding site [ion binding]; metal-binding site
1229758001811	homotetramer interface [polypeptide binding]; other site
1229758001812	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1229758001813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758001814	Walker A motif; other site
1229758001815	ATP binding site [chemical binding]; other site
1229758001816	Walker B motif; other site
1229758001817	arginine finger; other site
1229758001818	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1229758001819	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1229758001820	putative active site [active]
1229758001821	putative metal binding site [ion binding]; other site
1229758001822	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1229758001823	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1229758001824	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1229758001825	RuvA N terminal domain; Region: RuvA_N; pfam01330
1229758001826	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1229758001827	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1229758001828	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1229758001829	Substrate-binding site [chemical binding]; other site
1229758001830	Substrate specificity [chemical binding]; other site
1229758001831	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1229758001832	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1229758001833	Bacterial PH domain; Region: DUF304; cl01348
1229758001834	Predicted membrane protein [Function unknown]; Region: COG3428
1229758001835	Bacterial PH domain; Region: DUF304; pfam03703
1229758001836	Bacterial PH domain; Region: DUF304; cl01348
1229758001837	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1229758001838	HTH domain; Region: HTH_11; pfam08279
1229758001839	PRD domain; Region: PRD; pfam00874
1229758001840	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1229758001841	active site
1229758001842	P-loop; other site
1229758001843	phosphorylation site [posttranslational modification]
1229758001844	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1229758001845	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1229758001846	active site
1229758001847	phosphorylation site [posttranslational modification]
1229758001848	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1229758001849	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1229758001850	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1229758001851	active site
1229758001852	P-loop; other site
1229758001853	phosphorylation site [posttranslational modification]
1229758001854	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1229758001855	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1229758001856	DNA binding site [nucleotide binding]
1229758001857	active site
1229758001858	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1229758001859	RimM N-terminal domain; Region: RimM; pfam01782
1229758001860	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1229758001861	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229758001862	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229758001863	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758001864	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1229758001865	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1229758001866	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1229758001867	Walker A/P-loop; other site
1229758001868	ATP binding site [chemical binding]; other site
1229758001869	Q-loop/lid; other site
1229758001870	ABC transporter signature motif; other site
1229758001871	Walker B; other site
1229758001872	D-loop; other site
1229758001873	H-loop/switch region; other site
1229758001874	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1229758001875	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1229758001876	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1229758001877	putative ADP-binding pocket [chemical binding]; other site
1229758001878	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758001879	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758001880	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229758001881	Domain of unknown function (DUF1792); Region: DUF1792; cl07392
1229758001882	Domain of unknown function (DUF1792); Region: DUF1792; cl07392
1229758001883	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229758001884	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1229758001885	active site
1229758001886	nucleotide binding site [chemical binding]; other site
1229758001887	HIGH motif; other site
1229758001888	KMSKS motif; other site
1229758001889	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758001890	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229758001891	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229758001892	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229758001893	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758001894	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758001895	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229758001896	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229758001897	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229758001898	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1229758001899	ribonuclease Z; Region: RNase_Z; TIGR02651
1229758001900	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1229758001901	DHH family; Region: DHH; pfam01368
1229758001902	DHHA1 domain; Region: DHHA1; pfam02272
1229758001903	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1229758001904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758001905	active site
1229758001906	Thioredoxin; Region: Thioredoxin_5; pfam13743
1229758001907	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229758001908	synthetase active site [active]
1229758001909	NTP binding site [chemical binding]; other site
1229758001910	metal binding site [ion binding]; metal-binding site
1229758001911	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1229758001912	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1229758001913	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229758001914	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229758001915	active site
1229758001916	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1229758001917	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1229758001918	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1229758001919	Divalent cation transporter; Region: MgtE; pfam01769
1229758001920	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1229758001921	argininosuccinate synthase; Provisional; Region: PRK13820
1229758001922	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1229758001923	ANP binding site [chemical binding]; other site
1229758001924	Substrate Binding Site II [chemical binding]; other site
1229758001925	Substrate Binding Site I [chemical binding]; other site
1229758001926	argininosuccinate lyase; Provisional; Region: PRK00855
1229758001927	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1229758001928	active sites [active]
1229758001929	tetramer interface [polypeptide binding]; other site
1229758001930	ornithine carbamoyltransferase; Validated; Region: PRK02102
1229758001931	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229758001932	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229758001933	putative phosphoketolase; Provisional; Region: PRK05261
1229758001934	XFP N-terminal domain; Region: XFP_N; pfam09364
1229758001935	XFP C-terminal domain; Region: XFP_C; pfam09363
1229758001936	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1229758001937	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
1229758001938	dimerization interface [polypeptide binding]; other site
1229758001939	active site
1229758001940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758001941	S-adenosylmethionine binding site [chemical binding]; other site
1229758001942	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1229758001943	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1229758001944	CutC family; Region: CutC; cl01218
1229758001945	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1229758001946	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1229758001947	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1229758001948	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1229758001949	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1229758001950	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1229758001951	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1229758001952	active site
1229758001953	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1229758001954	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1229758001955	active site
1229758001956	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229758001957	substrate binding site [chemical binding]; other site
1229758001958	catalytic residues [active]
1229758001959	dimer interface [polypeptide binding]; other site
1229758001960	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1229758001961	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1229758001962	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1229758001963	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1229758001964	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1229758001965	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1229758001966	metal binding site [ion binding]; metal-binding site
1229758001967	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1229758001968	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1229758001969	dimer interface [polypeptide binding]; other site
1229758001970	active site
1229758001971	catalytic residue [active]
1229758001972	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1229758001973	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1229758001974	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1229758001975	RecX family; Region: RecX; cl00936
1229758001976	hypothetical protein; Provisional; Region: PRK13662
1229758001977	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1229758001978	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1229758001979	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1229758001980	Part of AAA domain; Region: AAA_19; pfam13245
1229758001981	Family description; Region: UvrD_C_2; pfam13538
1229758001982	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1229758001983	Rhomboid family; Region: Rhomboid; pfam01694
1229758001984	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1229758001985	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1229758001986	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229758001987	nucleotide binding site [chemical binding]; other site
1229758001988	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1229758001989	active site
1229758001990	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1229758001991	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1229758001992	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1229758001993	Walker A/P-loop; other site
1229758001994	ATP binding site [chemical binding]; other site
1229758001995	Q-loop/lid; other site
1229758001996	ABC transporter signature motif; other site
1229758001997	Walker B; other site
1229758001998	D-loop; other site
1229758001999	H-loop/switch region; other site
1229758002000	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1229758002001	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1229758002002	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
1229758002003	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1229758002004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229758002005	UDP-galactopyranose mutase; Region: GLF; pfam03275
1229758002006	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1229758002007	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1229758002008	Ligand binding site; other site
1229758002009	Putative Catalytic site; other site
1229758002010	DXD motif; other site
1229758002011	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229758002012	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1229758002013	active site
1229758002014	nucleotide binding site [chemical binding]; other site
1229758002015	HIGH motif; other site
1229758002016	KMSKS motif; other site
1229758002017	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229758002018	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758002019	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1229758002020	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1229758002021	Probable Catalytic site; other site
1229758002022	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1229758002023	active site
1229758002024	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758002025	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229758002026	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
1229758002027	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
1229758002028	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229758002029	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1229758002030	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1229758002031	DNA-binding site [nucleotide binding]; DNA binding site
1229758002032	RNA-binding motif; other site
1229758002033	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1229758002034	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1229758002035	dimer interface [polypeptide binding]; other site
1229758002036	ADP-ribose binding site [chemical binding]; other site
1229758002037	active site
1229758002038	nudix motif; other site
1229758002039	metal binding site [ion binding]; metal-binding site
1229758002040	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1229758002041	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1229758002042	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1229758002043	putative tRNA-binding site [nucleotide binding]; other site
1229758002044	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1229758002045	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229758002046	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758002047	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229758002048	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1229758002049	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1229758002050	DNA polymerase I; Provisional; Region: PRK05755
1229758002051	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1229758002052	active site
1229758002053	metal binding site 1 [ion binding]; metal-binding site
1229758002054	putative 5' ssDNA interaction site; other site
1229758002055	metal binding site 3; metal-binding site
1229758002056	metal binding site 2 [ion binding]; metal-binding site
1229758002057	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1229758002058	putative DNA binding site [nucleotide binding]; other site
1229758002059	putative metal binding site [ion binding]; other site
1229758002060	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1229758002061	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1229758002062	active site
1229758002063	DNA binding site [nucleotide binding]
1229758002064	catalytic site [active]
1229758002065	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1229758002066	DNA binding residues [nucleotide binding]
1229758002067	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1229758002068	putative dimer interface [polypeptide binding]; other site
1229758002069	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1229758002070	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1229758002071	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1229758002072	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1229758002073	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1229758002074	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229758002075	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1229758002076	active site 1 [active]
1229758002077	dimer interface [polypeptide binding]; other site
1229758002078	hexamer interface [polypeptide binding]; other site
1229758002079	active site 2 [active]
1229758002080	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758002081	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758002082	DNA binding site [nucleotide binding]
1229758002083	domain linker motif; other site
1229758002084	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1229758002085	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1229758002086	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229758002087	active site turn [active]
1229758002088	phosphorylation site [posttranslational modification]
1229758002089	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229758002090	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1229758002091	HPr interaction site; other site
1229758002092	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229758002093	active site
1229758002094	phosphorylation site [posttranslational modification]
1229758002095	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1229758002096	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1229758002097	substrate binding [chemical binding]; other site
1229758002098	active site
1229758002099	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1229758002100	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229758002101	active site
1229758002102	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1229758002103	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758002104	RNA binding surface [nucleotide binding]; other site
1229758002105	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1229758002106	active site
1229758002107	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1229758002108	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758002109	active site
1229758002110	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
1229758002111	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1229758002112	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1229758002113	catalytic site [active]
1229758002114	subunit interface [polypeptide binding]; other site
1229758002115	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
1229758002116	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229758002117	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1229758002118	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
1229758002119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758002120	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758002121	putative substrate translocation pore; other site
1229758002122	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1229758002123	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758002124	Zn2+ binding site [ion binding]; other site
1229758002125	Mg2+ binding site [ion binding]; other site
1229758002126	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1229758002127	synthetase active site [active]
1229758002128	NTP binding site [chemical binding]; other site
1229758002129	metal binding site [ion binding]; metal-binding site
1229758002130	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1229758002131	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1229758002132	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1229758002133	putative active site [active]
1229758002134	dimerization interface [polypeptide binding]; other site
1229758002135	putative tRNAtyr binding site [nucleotide binding]; other site
1229758002136	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1229758002137	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1229758002138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758002139	ATP binding site [chemical binding]; other site
1229758002140	Mg2+ binding site [ion binding]; other site
1229758002141	G-X-G motif; other site
1229758002142	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1229758002143	anchoring element; other site
1229758002144	dimer interface [polypeptide binding]; other site
1229758002145	ATP binding site [chemical binding]; other site
1229758002146	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1229758002147	active site
1229758002148	putative metal-binding site [ion binding]; other site
1229758002149	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1229758002150	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1229758002151	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1229758002152	CAP-like domain; other site
1229758002153	active site
1229758002154	primary dimer interface [polypeptide binding]; other site
1229758002155	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1229758002156	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1229758002157	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1229758002158	DHHA2 domain; Region: DHHA2; pfam02833
1229758002159	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1229758002160	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1229758002161	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1229758002162	Sm and related proteins; Region: Sm_like; cl00259
1229758002163	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1229758002164	putative oligomer interface [polypeptide binding]; other site
1229758002165	putative RNA binding site [nucleotide binding]; other site
1229758002166	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1229758002167	NusA N-terminal domain; Region: NusA_N; pfam08529
1229758002168	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1229758002169	RNA binding site [nucleotide binding]; other site
1229758002170	homodimer interface [polypeptide binding]; other site
1229758002171	NusA-like KH domain; Region: KH_5; pfam13184
1229758002172	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1229758002173	G-X-X-G motif; other site
1229758002174	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1229758002175	putative RNA binding cleft [nucleotide binding]; other site
1229758002176	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1229758002177	translation initiation factor IF-2; Region: IF-2; TIGR00487
1229758002178	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1229758002179	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1229758002180	G1 box; other site
1229758002181	putative GEF interaction site [polypeptide binding]; other site
1229758002182	GTP/Mg2+ binding site [chemical binding]; other site
1229758002183	Switch I region; other site
1229758002184	G2 box; other site
1229758002185	G3 box; other site
1229758002186	Switch II region; other site
1229758002187	G4 box; other site
1229758002188	G5 box; other site
1229758002189	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1229758002190	Translation-initiation factor 2; Region: IF-2; pfam11987
1229758002191	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1229758002192	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1229758002193	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1229758002194	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758002195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758002196	homodimer interface [polypeptide binding]; other site
1229758002197	catalytic residue [active]
1229758002198	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1229758002199	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1229758002200	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1229758002201	RNA binding site [nucleotide binding]; other site
1229758002202	active site
1229758002203	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1229758002204	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1229758002205	active site
1229758002206	Riboflavin kinase; Region: Flavokinase; smart00904
1229758002207	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1229758002208	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1229758002209	GrpE; Region: GrpE; pfam01025
1229758002210	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1229758002211	dimer interface [polypeptide binding]; other site
1229758002212	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1229758002213	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1229758002214	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1229758002215	nucleotide binding site [chemical binding]; other site
1229758002216	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1229758002217	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1229758002218	HSP70 interaction site [polypeptide binding]; other site
1229758002219	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1229758002220	substrate binding site [polypeptide binding]; other site
1229758002221	dimer interface [polypeptide binding]; other site
1229758002222	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1229758002223	active site
1229758002224	catalytic residues [active]
1229758002225	metal binding site [ion binding]; metal-binding site
1229758002226	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
1229758002227	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1229758002228	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1229758002229	active site
1229758002230	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1229758002231	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1229758002232	G1 box; other site
1229758002233	putative GEF interaction site [polypeptide binding]; other site
1229758002234	GTP/Mg2+ binding site [chemical binding]; other site
1229758002235	Switch I region; other site
1229758002236	G2 box; other site
1229758002237	G3 box; other site
1229758002238	Switch II region; other site
1229758002239	G4 box; other site
1229758002240	G5 box; other site
1229758002241	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1229758002242	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1229758002243	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1229758002244	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1229758002245	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1229758002246	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229758002247	active site
1229758002248	metal binding site [ion binding]; metal-binding site
1229758002249	DNA binding site [nucleotide binding]
1229758002250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758002251	Walker A/P-loop; other site
1229758002252	ATP binding site [chemical binding]; other site
1229758002253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758002254	ABC transporter signature motif; other site
1229758002255	Walker B; other site
1229758002256	D-loop; other site
1229758002257	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1229758002258	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1229758002259	generic binding surface II; other site
1229758002260	generic binding surface I; other site
1229758002261	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
1229758002262	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758002263	Zn2+ binding site [ion binding]; other site
1229758002264	Mg2+ binding site [ion binding]; other site
1229758002265	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1229758002266	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1229758002267	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1229758002268	HIT family signature motif; other site
1229758002269	catalytic residue [active]
1229758002270	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1229758002271	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229758002272	Walker A/P-loop; other site
1229758002273	ATP binding site [chemical binding]; other site
1229758002274	Q-loop/lid; other site
1229758002275	ABC transporter signature motif; other site
1229758002276	Walker B; other site
1229758002277	D-loop; other site
1229758002278	H-loop/switch region; other site
1229758002279	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1229758002280	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1229758002281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758002282	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758002283	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1229758002284	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1229758002285	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1229758002286	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229758002287	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1229758002288	active site
1229758002289	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1229758002290	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229758002291	putative active site [active]
1229758002292	putative metal binding site [ion binding]; other site
1229758002293	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1229758002294	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229758002295	active site
1229758002296	metal binding site [ion binding]; metal-binding site
1229758002297	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229758002298	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
1229758002299	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1229758002300	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1229758002301	homodimer interface [polypeptide binding]; other site
1229758002302	substrate-cofactor binding pocket; other site
1229758002303	catalytic residue [active]
1229758002304	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1229758002305	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229758002306	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229758002307	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229758002308	NAD binding site [chemical binding]; other site
1229758002309	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229758002310	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1229758002311	putative active site [active]
1229758002312	catalytic site [active]
1229758002313	putative metal binding site [ion binding]; other site
1229758002314	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1229758002315	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229758002316	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
1229758002317	putative active site [active]
1229758002318	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1229758002319	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1229758002320	FMN binding site [chemical binding]; other site
1229758002321	active site
1229758002322	catalytic residues [active]
1229758002323	substrate binding site [chemical binding]; other site
1229758002324	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1229758002325	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758002326	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229758002327	HicB family; Region: HicB; pfam05534
1229758002328	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1229758002329	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1229758002330	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1229758002331	Flavoprotein; Region: Flavoprotein; pfam02441
1229758002332	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1229758002333	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1229758002334	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1229758002335	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1229758002336	active site
1229758002337	HIGH motif; other site
1229758002338	KMSK motif region; other site
1229758002339	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1229758002340	tRNA binding surface [nucleotide binding]; other site
1229758002341	anticodon binding site; other site
1229758002342	Arginine repressor [Transcription]; Region: ArgR; COG1438
1229758002343	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1229758002344	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1229758002345	Transglycosylase; Region: Transgly; pfam00912
1229758002346	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1229758002347	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229758002348	hypothetical protein; Provisional; Region: PRK13676
1229758002349	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1229758002350	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1229758002351	Catalytic site [active]
1229758002352	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229758002353	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1229758002354	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1229758002355	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1229758002356	dihydroorotase; Validated; Region: pyrC; PRK09357
1229758002357	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1229758002358	active site
1229758002359	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1229758002360	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1229758002361	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1229758002362	catalytic site [active]
1229758002363	subunit interface [polypeptide binding]; other site
1229758002364	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1229758002365	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229758002366	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1229758002367	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1229758002368	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229758002369	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229758002370	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1229758002371	IMP binding site; other site
1229758002372	dimer interface [polypeptide binding]; other site
1229758002373	interdomain contacts; other site
1229758002374	partial ornithine binding site; other site
1229758002375	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1229758002376	active site
1229758002377	dimer interface [polypeptide binding]; other site
1229758002378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758002379	active site
1229758002380	LexA repressor; Validated; Region: PRK00215
1229758002381	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1229758002382	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1229758002383	Catalytic site [active]
1229758002384	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1229758002385	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1229758002386	putative acyl-acceptor binding pocket; other site
1229758002387	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1229758002388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758002389	S-adenosylmethionine binding site [chemical binding]; other site
1229758002390	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1229758002391	GIY-YIG motif/motif A; other site
1229758002392	putative active site [active]
1229758002393	putative metal binding site [ion binding]; other site
1229758002394	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1229758002395	rRNA interaction site [nucleotide binding]; other site
1229758002396	S8 interaction site; other site
1229758002397	putative laminin-1 binding site; other site
1229758002398	elongation factor Ts; Provisional; Region: tsf; PRK09377
1229758002399	UBA/TS-N domain; Region: UBA; pfam00627
1229758002400	Elongation factor TS; Region: EF_TS; pfam00889
1229758002401	Elongation factor TS; Region: EF_TS; pfam00889
1229758002402	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1229758002403	putative nucleotide binding site [chemical binding]; other site
1229758002404	uridine monophosphate binding site [chemical binding]; other site
1229758002405	homohexameric interface [polypeptide binding]; other site
1229758002406	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1229758002407	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1229758002408	hinge region; other site
1229758002409	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
1229758002410	motif 1; other site
1229758002411	dimer interface [polypeptide binding]; other site
1229758002412	active site
1229758002413	motif 2; other site
1229758002414	motif 3; other site
1229758002415	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1229758002416	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758002417	Zn2+ binding site [ion binding]; other site
1229758002418	Mg2+ binding site [ion binding]; other site
1229758002419	putative oxidoreductase; Provisional; Region: PRK10206
1229758002420	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1229758002421	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1229758002422	GTP-binding protein LepA; Provisional; Region: PRK05433
1229758002423	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1229758002424	G1 box; other site
1229758002425	putative GEF interaction site [polypeptide binding]; other site
1229758002426	GTP/Mg2+ binding site [chemical binding]; other site
1229758002427	Switch I region; other site
1229758002428	G2 box; other site
1229758002429	G3 box; other site
1229758002430	Switch II region; other site
1229758002431	G4 box; other site
1229758002432	G5 box; other site
1229758002433	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1229758002434	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1229758002435	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1229758002436	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1229758002437	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1229758002438	putative NAD(P) binding site [chemical binding]; other site
1229758002439	dimer interface [polypeptide binding]; other site
1229758002440	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1229758002441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758002442	S-adenosylmethionine binding site [chemical binding]; other site
1229758002443	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1229758002444	RNA methyltransferase, RsmE family; Region: TIGR00046
1229758002445	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1229758002446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758002447	Walker A/P-loop; other site
1229758002448	ATP binding site [chemical binding]; other site
1229758002449	Q-loop/lid; other site
1229758002450	ABC transporter signature motif; other site
1229758002451	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758002452	Walker B; other site
1229758002453	D-loop; other site
1229758002454	ABC transporter; Region: ABC_tran_2; pfam12848
1229758002455	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758002456	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1229758002457	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1229758002458	dimer interface [polypeptide binding]; other site
1229758002459	active site
1229758002460	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1229758002461	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1229758002462	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1229758002463	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229758002464	active site
1229758002465	DNA binding site [nucleotide binding]
1229758002466	Int/Topo IB signature motif; other site
1229758002467	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1229758002468	active site
1229758002469	catalytic residues [active]
1229758002470	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1229758002471	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1229758002472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758002473	catalytic residue [active]
1229758002474	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1229758002475	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1229758002476	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1229758002477	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1229758002478	active site
1229758002479	ribulose/triose binding site [chemical binding]; other site
1229758002480	phosphate binding site [ion binding]; other site
1229758002481	substrate (anthranilate) binding pocket [chemical binding]; other site
1229758002482	product (indole) binding pocket [chemical binding]; other site
1229758002483	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1229758002484	active site
1229758002485	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1229758002486	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1229758002487	substrate binding site [chemical binding]; other site
1229758002488	active site
1229758002489	catalytic residues [active]
1229758002490	heterodimer interface [polypeptide binding]; other site
1229758002491	anthranilate synthase component I; Provisional; Region: PRK13570
1229758002492	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1229758002493	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1229758002494	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1229758002495	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1229758002496	glutamine binding [chemical binding]; other site
1229758002497	catalytic triad [active]
1229758002498	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1229758002499	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1229758002500	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1229758002501	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1229758002502	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1229758002503	RNA binding site [nucleotide binding]; other site
1229758002504	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229758002505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002506	Coenzyme A binding pocket [chemical binding]; other site
1229758002507	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1229758002508	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229758002509	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229758002510	dimer interface [polypeptide binding]; other site
1229758002511	substrate binding site [chemical binding]; other site
1229758002512	ATP binding site [chemical binding]; other site
1229758002513	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1229758002514	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1229758002515	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1229758002516	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1229758002517	dimer interface [polypeptide binding]; other site
1229758002518	tetramer interface [polypeptide binding]; other site
1229758002519	PYR/PP interface [polypeptide binding]; other site
1229758002520	TPP binding site [chemical binding]; other site
1229758002521	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1229758002522	TPP-binding site; other site
1229758002523	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1229758002524	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1229758002525	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1229758002526	metal binding site [ion binding]; metal-binding site
1229758002527	substrate binding pocket [chemical binding]; other site
1229758002528	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1229758002529	Family of unknown function (DUF633); Region: DUF633; pfam04816
1229758002530	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1229758002531	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1229758002532	peptidase T; Region: peptidase-T; TIGR01882
1229758002533	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1229758002534	metal binding site [ion binding]; metal-binding site
1229758002535	dimer interface [polypeptide binding]; other site
1229758002536	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1229758002537	active site
1229758002538	catalytic triad [active]
1229758002539	oxyanion hole [active]
1229758002540	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1229758002541	hypothetical protein; Provisional; Region: PRK13672
1229758002542	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1229758002543	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1229758002544	GTP/Mg2+ binding site [chemical binding]; other site
1229758002545	G4 box; other site
1229758002546	G5 box; other site
1229758002547	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
1229758002548	G1 box; other site
1229758002549	G1 box; other site
1229758002550	GTP/Mg2+ binding site [chemical binding]; other site
1229758002551	Switch I region; other site
1229758002552	G2 box; other site
1229758002553	G2 box; other site
1229758002554	Switch I region; other site
1229758002555	G3 box; other site
1229758002556	G3 box; other site
1229758002557	Switch II region; other site
1229758002558	Switch II region; other site
1229758002559	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1229758002560	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229758002561	active site
1229758002562	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1229758002563	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1229758002564	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758002565	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1229758002566	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758002567	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1229758002568	IncA protein; Region: IncA; pfam04156
1229758002569	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229758002570	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1229758002571	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1229758002572	potential frameshift: common BLAST hit: gi|338202966|ref|YP_004649111.1| ISL3 family transposase ISLasa4c
1229758002573	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229758002574	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229758002575	Integrase core domain; Region: rve; pfam00665
1229758002576	DNA primase; Validated; Region: dnaG; PRK05667
1229758002577	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1229758002578	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1229758002579	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1229758002580	active site
1229758002581	metal binding site [ion binding]; metal-binding site
1229758002582	interdomain interaction site; other site
1229758002583	HeH/LEM domain; Region: HeH; pfam12949
1229758002584	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1229758002585	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1229758002586	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1229758002587	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1229758002588	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1229758002589	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1229758002590	DNA binding residues [nucleotide binding]
1229758002591	QueT transporter; Region: QueT; pfam06177
1229758002592	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1229758002593	classical (c) SDRs; Region: SDR_c; cd05233
1229758002594	NAD(P) binding site [chemical binding]; other site
1229758002595	active site
1229758002596	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758002597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758002598	non-specific DNA binding site [nucleotide binding]; other site
1229758002599	salt bridge; other site
1229758002600	sequence-specific DNA binding site [nucleotide binding]; other site
1229758002601	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1229758002602	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002603	Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324
1229758002604	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229758002605	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002606	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002607	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002608	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002609	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002610	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758002611	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229758002612	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1229758002613	putative NAD(P) binding site [chemical binding]; other site
1229758002614	catalytic Zn binding site [ion binding]; other site
1229758002615	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1229758002616	catalytic residues [active]
1229758002617	dimer interface [polypeptide binding]; other site
1229758002618	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229758002619	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1229758002620	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1229758002621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229758002622	Protein of unknown function (DUF419); Region: DUF419; cl15265
1229758002623	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002624	Coenzyme A binding pocket [chemical binding]; other site
1229758002625	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1229758002626	Protein of unknown function DUF262; Region: DUF262; pfam03235
1229758002627	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1229758002628	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229758002629	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229758002630	Integrase core domain; Region: rve; pfam00665
1229758002631	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758002632	non-specific DNA binding site [nucleotide binding]; other site
1229758002633	salt bridge; other site
1229758002634	sequence-specific DNA binding site [nucleotide binding]; other site
1229758002635	Replication initiation factor; Region: Rep_trans; pfam02486
1229758002636	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1229758002637	Active site serine [active]
1229758002638	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758002639	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229758002640	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229758002641	AAA-like domain; Region: AAA_10; pfam12846
1229758002642	CHAP domain; Region: CHAP; pfam05257
1229758002643	Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340
1229758002644	Cgr1 family; Region: Cgr1; pfam03879
1229758002645	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1229758002646	DsrE/DsrF-like family; Region: DrsE; cl00672
1229758002647	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229758002648	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1229758002649	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1229758002650	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1229758002651	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1229758002652	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1229758002653	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1229758002654	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1229758002655	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758002656	ATP binding site [chemical binding]; other site
1229758002657	putative Mg++ binding site [ion binding]; other site
1229758002658	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1229758002659	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229758002660	active site
1229758002661	catalytic site [active]
1229758002662	substrate binding site [chemical binding]; other site
1229758002663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002664	Coenzyme A binding pocket [chemical binding]; other site
1229758002665	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1229758002666	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229758002667	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002668	Coenzyme A binding pocket [chemical binding]; other site
1229758002669	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1229758002670	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1229758002671	DNA binding residues [nucleotide binding]
1229758002672	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229758002673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002674	Coenzyme A binding pocket [chemical binding]; other site
1229758002675	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229758002676	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758002677	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758002678	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1229758002679	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1229758002680	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1229758002681	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1229758002682	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1229758002683	PYR/PP interface [polypeptide binding]; other site
1229758002684	dimer interface [polypeptide binding]; other site
1229758002685	tetramer interface [polypeptide binding]; other site
1229758002686	TPP binding site [chemical binding]; other site
1229758002687	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229758002688	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1229758002689	TPP-binding site [chemical binding]; other site
1229758002690	LrgB-like family; Region: LrgB; cl00596
1229758002691	LrgA family; Region: LrgA; cl00608
1229758002692	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
1229758002693	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758002694	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758002695	non-specific DNA binding site [nucleotide binding]; other site
1229758002696	salt bridge; other site
1229758002697	sequence-specific DNA binding site [nucleotide binding]; other site
1229758002698	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758002699	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758002700	DNA binding site [nucleotide binding]
1229758002701	domain linker motif; other site
1229758002702	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229758002703	dimerization interface [polypeptide binding]; other site
1229758002704	ligand binding site [chemical binding]; other site
1229758002705	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229758002706	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229758002707	Ca binding site [ion binding]; other site
1229758002708	active site
1229758002709	catalytic site [active]
1229758002710	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
1229758002711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758002712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758002713	putative substrate translocation pore; other site
1229758002714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758002715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758002716	Bacterial transcriptional repressor; Region: TetR; pfam13972
1229758002717	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
1229758002718	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229758002719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229758002720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1229758002721	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1229758002722	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758002723	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758002724	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229758002725	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229758002726	ligand binding site [chemical binding]; other site
1229758002727	flexible hinge region; other site
1229758002728	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
1229758002729	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1229758002730	conserved cys residue [active]
1229758002731	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229758002732	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
1229758002733	active site
1229758002734	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1229758002735	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1229758002736	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1229758002737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758002738	acetoin reductases; Region: 23BDH; TIGR02415
1229758002739	NAD(P) binding site [chemical binding]; other site
1229758002740	active site
1229758002741	CAAX protease self-immunity; Region: Abi; pfam02517
1229758002742	Putative transcription activator [Transcription]; Region: TenA; COG0819
1229758002743	acetylornithine deacetylase; Validated; Region: PRK08596
1229758002744	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1229758002745	metal binding site [ion binding]; metal-binding site
1229758002746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758002747	NAD(P) binding site [chemical binding]; other site
1229758002748	short chain dehydrogenase; Validated; Region: PRK07069
1229758002749	active site
1229758002750	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1229758002751	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1229758002752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758002753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758002754	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229758002755	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1229758002756	putative dimer interface [polypeptide binding]; other site
1229758002757	catalytic triad [active]
1229758002758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229758002760	Coenzyme A binding pocket [chemical binding]; other site
1229758002761	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1229758002762	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1229758002763	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1229758002764	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229758002765	MarR family; Region: MarR; pfam01047
1229758002766	Predicted transcriptional regulator [Transcription]; Region: COG1959
1229758002767	Transcriptional regulator; Region: Rrf2; pfam02082
1229758002768	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1229758002769	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758002770	NAD(P) binding site [chemical binding]; other site
1229758002771	active site
1229758002772	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1229758002773	GAF domain; Region: GAF_2; pfam13185
1229758002774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758002775	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758002776	putative substrate translocation pore; other site
1229758002777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758002778	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758002779	dimerization interface [polypeptide binding]; other site
1229758002780	putative DNA binding site [nucleotide binding]; other site
1229758002781	putative Zn2+ binding site [ion binding]; other site
1229758002782	MepB protein; Region: MepB; pfam08877
1229758002783	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229758002784	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229758002785	active site
1229758002786	catalytic tetrad [active]
1229758002787	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1229758002788	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1229758002789	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758002790	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1229758002791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758002792	motif II; other site
1229758002793	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1229758002794	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1229758002795	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1229758002796	substrate binding site [chemical binding]; other site
1229758002797	multimerization interface [polypeptide binding]; other site
1229758002798	ATP binding site [chemical binding]; other site
1229758002799	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
1229758002800	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
1229758002801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758002802	NAD(P) binding site [chemical binding]; other site
1229758002803	active site
1229758002804	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
1229758002805	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
1229758002806	putative catalytic cysteine [active]
1229758002807	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
1229758002808	xanthine permease; Region: pbuX; TIGR03173
1229758002809	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1229758002810	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229758002811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1229758002812	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
1229758002813	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1229758002814	Phosphotransferase enzyme family; Region: APH; pfam01636
1229758002815	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1229758002816	active site
1229758002817	ATP binding site [chemical binding]; other site
1229758002818	Ecdysteroid kinase; Region: EcKinase; cl17738
1229758002819	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1229758002820	substrate binding site [chemical binding]; other site
1229758002821	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1229758002822	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1229758002823	trimer interface [polypeptide binding]; other site
1229758002824	active site
1229758002825	substrate binding site [chemical binding]; other site
1229758002826	CoA binding site [chemical binding]; other site
1229758002827	cystathionine beta-lyase; Provisional; Region: PRK07671
1229758002828	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1229758002829	homodimer interface [polypeptide binding]; other site
1229758002830	substrate-cofactor binding pocket; other site
1229758002831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758002832	catalytic residue [active]
1229758002833	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1229758002834	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1229758002835	dimer interface [polypeptide binding]; other site
1229758002836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758002837	catalytic residue [active]
1229758002838	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1229758002839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758002840	motif II; other site
1229758002841	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1229758002842	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1229758002843	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1229758002844	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1229758002845	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1229758002846	HPr interaction site; other site
1229758002847	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229758002848	active site
1229758002849	phosphorylation site [posttranslational modification]
1229758002850	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1229758002851	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229758002852	active site turn [active]
1229758002853	phosphorylation site [posttranslational modification]
1229758002854	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229758002855	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229758002856	DNA-binding site [nucleotide binding]; DNA binding site
1229758002857	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1229758002858	UTRA domain; Region: UTRA; pfam07702
1229758002859	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1229758002860	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1229758002861	NAD(P) binding site [chemical binding]; other site
1229758002862	catalytic residues [active]
1229758002863	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
1229758002864	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1229758002865	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229758002866	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1229758002867	active site
1229758002868	catalytic site [active]
1229758002869	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
1229758002870	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1229758002871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758002872	Coenzyme A binding pocket [chemical binding]; other site
1229758002873	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1229758002874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758002875	S-adenosylmethionine binding site [chemical binding]; other site
1229758002876	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758002877	catalytic core [active]
1229758002878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229758002879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229758002880	Walker A/P-loop; other site
1229758002881	ATP binding site [chemical binding]; other site
1229758002882	Q-loop/lid; other site
1229758002883	ABC transporter signature motif; other site
1229758002884	Walker B; other site
1229758002885	D-loop; other site
1229758002886	H-loop/switch region; other site
1229758002887	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229758002888	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229758002889	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1229758002890	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1229758002891	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1229758002892	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
1229758002893	active site
1229758002894	phosphorylation site [posttranslational modification]
1229758002895	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1229758002896	active pocket/dimerization site; other site
1229758002897	active site
1229758002898	phosphorylation site [posttranslational modification]
1229758002899	DNA topoisomerase I; Validated; Region: PRK05582
1229758002900	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1229758002901	active site
1229758002902	interdomain interaction site; other site
1229758002903	putative metal-binding site [ion binding]; other site
1229758002904	nucleotide binding site [chemical binding]; other site
1229758002905	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1229758002906	domain I; other site
1229758002907	DNA binding groove [nucleotide binding]
1229758002908	phosphate binding site [ion binding]; other site
1229758002909	domain II; other site
1229758002910	domain III; other site
1229758002911	nucleotide binding site [chemical binding]; other site
1229758002912	catalytic site [active]
1229758002913	domain IV; other site
1229758002914	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1229758002915	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1229758002916	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1229758002917	DNA protecting protein DprA; Region: dprA; TIGR00732
1229758002918	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1229758002919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758002920	Walker A/P-loop; other site
1229758002921	ATP binding site [chemical binding]; other site
1229758002922	Q-loop/lid; other site
1229758002923	ABC transporter signature motif; other site
1229758002924	Walker B; other site
1229758002925	D-loop; other site
1229758002926	H-loop/switch region; other site
1229758002927	ABC transporter; Region: ABC_tran_2; pfam12848
1229758002928	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1229758002929	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1229758002930	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1229758002931	active site
1229758002932	FMN binding site [chemical binding]; other site
1229758002933	substrate binding site [chemical binding]; other site
1229758002934	catalytic residues [active]
1229758002935	homodimer interface [polypeptide binding]; other site
1229758002936	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1229758002937	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229758002938	Catalytic site [active]
1229758002939	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1229758002940	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1229758002941	propionate/acetate kinase; Provisional; Region: PRK12379
1229758002942	Bacterial SH3 domain; Region: SH3_3; pfam08239
1229758002943	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1229758002944	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1229758002945	active site
1229758002946	metal binding site [ion binding]; metal-binding site
1229758002947	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1229758002948	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1229758002949	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1229758002950	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1229758002951	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1229758002952	dimer interface [polypeptide binding]; other site
1229758002953	active site
1229758002954	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1229758002955	folate binding site [chemical binding]; other site
1229758002956	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1229758002957	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1229758002958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758002959	catalytic residue [active]
1229758002960	homoserine dehydrogenase; Provisional; Region: PRK06349
1229758002961	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1229758002962	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1229758002963	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229758002964	homoserine kinase; Provisional; Region: PRK01212
1229758002965	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229758002966	aspartate kinase; Reviewed; Region: PRK09034
1229758002967	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1229758002968	putative catalytic residues [active]
1229758002969	putative nucleotide binding site [chemical binding]; other site
1229758002970	putative aspartate binding site [chemical binding]; other site
1229758002971	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1229758002972	allosteric regulatory residue; other site
1229758002973	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229758002974	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1229758002975	active site
1229758002976	homotetramer interface [polypeptide binding]; other site
1229758002977	homodimer interface [polypeptide binding]; other site
1229758002978	DNA repair protein RecO; Region: reco; TIGR00613
1229758002979	Recombination protein O N terminal; Region: RecO_N; pfam11967
1229758002980	Recombination protein O C terminal; Region: RecO_C; pfam02565
1229758002981	Predicted ATPase [General function prediction only]; Region: COG3910
1229758002982	GTPase Era; Reviewed; Region: era; PRK00089
1229758002983	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1229758002984	G1 box; other site
1229758002985	GTP/Mg2+ binding site [chemical binding]; other site
1229758002986	Switch I region; other site
1229758002987	G2 box; other site
1229758002988	Switch II region; other site
1229758002989	G3 box; other site
1229758002990	G4 box; other site
1229758002991	G5 box; other site
1229758002992	KH domain; Region: KH_2; pfam07650
1229758002993	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1229758002994	metal-binding heat shock protein; Provisional; Region: PRK00016
1229758002995	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1229758002996	PhoH-like protein; Region: PhoH; pfam02562
1229758002997	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1229758002998	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
1229758002999	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1229758003000	domain interfaces; other site
1229758003001	active site
1229758003002	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1229758003003	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1229758003004	active site
1229758003005	PHP Thumb interface [polypeptide binding]; other site
1229758003006	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1229758003007	generic binding surface II; other site
1229758003008	generic binding surface I; other site
1229758003009	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1229758003010	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1229758003011	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1229758003012	active site
1229758003013	catalytic residue [active]
1229758003014	dimer interface [polypeptide binding]; other site
1229758003015	Prephenate dehydratase; Region: PDT; pfam00800
1229758003016	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1229758003017	shikimate kinase; Reviewed; Region: aroK; PRK00131
1229758003018	ADP binding site [chemical binding]; other site
1229758003019	magnesium binding site [ion binding]; other site
1229758003020	putative shikimate binding site; other site
1229758003021	Chorismate mutase type II; Region: CM_2; smart00830
1229758003022	prephenate dehydrogenase; Validated; Region: PRK08507
1229758003023	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1229758003024	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1229758003025	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1229758003026	hinge; other site
1229758003027	active site
1229758003028	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1229758003029	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1229758003030	Tetramer interface [polypeptide binding]; other site
1229758003031	active site
1229758003032	FMN-binding site [chemical binding]; other site
1229758003033	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1229758003034	active site
1229758003035	dimer interface [polypeptide binding]; other site
1229758003036	metal binding site [ion binding]; metal-binding site
1229758003037	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1229758003038	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1229758003039	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1229758003040	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1229758003041	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1229758003042	shikimate binding site; other site
1229758003043	NAD(P) binding site [chemical binding]; other site
1229758003044	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1229758003045	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1229758003046	TPP-binding site [chemical binding]; other site
1229758003047	dimer interface [polypeptide binding]; other site
1229758003048	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1229758003049	PYR/PP interface [polypeptide binding]; other site
1229758003050	dimer interface [polypeptide binding]; other site
1229758003051	TPP binding site [chemical binding]; other site
1229758003052	EDD domain protein, DegV family; Region: DegV; TIGR00762
1229758003053	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1229758003054	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1229758003055	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1229758003056	folate binding site [chemical binding]; other site
1229758003057	NADP+ binding site [chemical binding]; other site
1229758003058	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1229758003059	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1229758003060	active site
1229758003061	NTP binding site [chemical binding]; other site
1229758003062	metal binding triad [ion binding]; metal-binding site
1229758003063	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1229758003064	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1229758003065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229758003066	binding surface
1229758003067	TPR motif; other site
1229758003068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229758003069	binding surface
1229758003070	TPR motif; other site
1229758003071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1229758003072	binding surface
1229758003073	TPR motif; other site
1229758003074	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1229758003075	IHF dimer interface [polypeptide binding]; other site
1229758003076	IHF - DNA interface [nucleotide binding]; other site
1229758003077	GTP-binding protein Der; Reviewed; Region: PRK00093
1229758003078	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1229758003079	G1 box; other site
1229758003080	GTP/Mg2+ binding site [chemical binding]; other site
1229758003081	Switch I region; other site
1229758003082	G2 box; other site
1229758003083	Switch II region; other site
1229758003084	G3 box; other site
1229758003085	G4 box; other site
1229758003086	G5 box; other site
1229758003087	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1229758003088	G1 box; other site
1229758003089	GTP/Mg2+ binding site [chemical binding]; other site
1229758003090	Switch I region; other site
1229758003091	G2 box; other site
1229758003092	G3 box; other site
1229758003093	Switch II region; other site
1229758003094	G4 box; other site
1229758003095	G5 box; other site
1229758003096	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1229758003097	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1229758003098	RNA binding site [nucleotide binding]; other site
1229758003099	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1229758003100	RNA binding site [nucleotide binding]; other site
1229758003101	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1229758003102	RNA binding site [nucleotide binding]; other site
1229758003103	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1229758003104	RNA binding site [nucleotide binding]; other site
1229758003105	cytidylate kinase; Provisional; Region: cmk; PRK00023
1229758003106	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1229758003107	CMP-binding site; other site
1229758003108	The sites determining sugar specificity; other site
1229758003109	Predicted membrane protein [Function unknown]; Region: COG3601
1229758003110	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229758003111	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1229758003112	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758003113	RNA binding surface [nucleotide binding]; other site
1229758003114	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1229758003115	active site
1229758003116	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1229758003117	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1229758003118	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1229758003119	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1229758003120	active site
1229758003121	Int/Topo IB signature motif; other site
1229758003122	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1229758003123	S1 domain; Region: S1_2; pfam13509
1229758003124	Yqey-like protein; Region: YqeY; pfam09424
1229758003125	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1229758003126	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1229758003127	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1229758003128	active site
1229758003129	Zn binding site [ion binding]; other site
1229758003130	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1229758003131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003132	putative substrate translocation pore; other site
1229758003133	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1229758003134	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1229758003135	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229758003136	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1229758003137	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1229758003138	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1229758003139	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1229758003140	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1229758003141	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1229758003142	dimer interface [polypeptide binding]; other site
1229758003143	anticodon binding site; other site
1229758003144	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229758003145	motif 1; other site
1229758003146	dimer interface [polypeptide binding]; other site
1229758003147	active site
1229758003148	motif 2; other site
1229758003149	GAD domain; Region: GAD; pfam02938
1229758003150	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229758003151	active site
1229758003152	motif 3; other site
1229758003153	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1229758003154	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1229758003155	dimer interface [polypeptide binding]; other site
1229758003156	motif 1; other site
1229758003157	active site
1229758003158	motif 2; other site
1229758003159	motif 3; other site
1229758003160	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1229758003161	anticodon binding site; other site
1229758003162	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229758003163	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229758003164	Ca binding site [ion binding]; other site
1229758003165	active site
1229758003166	catalytic site [active]
1229758003167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003168	putative substrate translocation pore; other site
1229758003169	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758003170	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1229758003171	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1229758003172	Ca binding site [ion binding]; other site
1229758003173	active site
1229758003174	catalytic site [active]
1229758003175	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1229758003176	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758003177	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758003178	DNA binding site [nucleotide binding]
1229758003179	domain linker motif; other site
1229758003180	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229758003181	dimerization interface [polypeptide binding]; other site
1229758003182	ligand binding site [chemical binding]; other site
1229758003183	maltose phosphorylase; Provisional; Region: PRK13807
1229758003184	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1229758003185	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1229758003186	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1229758003187	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1229758003188	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1229758003189	trimer interface [polypeptide binding]; other site
1229758003190	active site
1229758003191	substrate binding site [chemical binding]; other site
1229758003192	CoA binding site [chemical binding]; other site
1229758003193	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1229758003194	dimer interface [polypeptide binding]; other site
1229758003195	FMN binding site [chemical binding]; other site
1229758003196	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229758003197	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1229758003198	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758003199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758003200	homodimer interface [polypeptide binding]; other site
1229758003201	catalytic residue [active]
1229758003202	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1229758003203	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1229758003204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1229758003205	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1229758003206	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1229758003207	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1229758003208	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1229758003209	putative dimer interface [polypeptide binding]; other site
1229758003210	putative anticodon binding site; other site
1229758003211	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1229758003212	homodimer interface [polypeptide binding]; other site
1229758003213	motif 1; other site
1229758003214	motif 2; other site
1229758003215	active site
1229758003216	motif 3; other site
1229758003217	aspartate aminotransferase; Provisional; Region: PRK05764
1229758003218	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758003219	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758003220	homodimer interface [polypeptide binding]; other site
1229758003221	catalytic residue [active]
1229758003222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1229758003223	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229758003224	active site
1229758003225	catalytic site [active]
1229758003226	substrate binding site [chemical binding]; other site
1229758003227	mevalonate kinase; Region: mevalon_kin; TIGR00549
1229758003228	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229758003229	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1229758003230	active site
1229758003231	catalytic site [active]
1229758003232	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229758003233	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229758003234	active site
1229758003235	catalytic tetrad [active]
1229758003236	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1229758003237	active site
1229758003238	catalytic triad [active]
1229758003239	oxyanion hole [active]
1229758003240	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1229758003241	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1229758003242	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758003243	active site
1229758003244	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1229758003245	AAA domain; Region: AAA_30; pfam13604
1229758003246	Family description; Region: UvrD_C_2; pfam13538
1229758003247	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758003248	catalytic core [active]
1229758003249	Putative amino acid metabolism; Region: DUF1831; pfam08866
1229758003250	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1229758003251	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1229758003252	ligand binding site [chemical binding]; other site
1229758003253	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1229758003254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758003255	S-adenosylmethionine binding site [chemical binding]; other site
1229758003256	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1229758003257	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229758003258	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1229758003259	substrate binding site [chemical binding]; other site
1229758003260	dimer interface [polypeptide binding]; other site
1229758003261	ATP binding site [chemical binding]; other site
1229758003262	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1229758003263	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1229758003264	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1229758003265	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1229758003266	generic binding surface II; other site
1229758003267	generic binding surface I; other site
1229758003268	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1229758003269	active site
1229758003270	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1229758003271	active site
1229758003272	catalytic site [active]
1229758003273	substrate binding site [chemical binding]; other site
1229758003274	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1229758003275	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1229758003276	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1229758003277	dimer interface [polypeptide binding]; other site
1229758003278	motif 1; other site
1229758003279	active site
1229758003280	motif 2; other site
1229758003281	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1229758003282	putative deacylase active site [active]
1229758003283	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1229758003284	active site
1229758003285	motif 3; other site
1229758003286	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1229758003287	anticodon binding site; other site
1229758003288	RIP metalloprotease RseP; Region: TIGR00054
1229758003289	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229758003290	active site
1229758003291	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1229758003292	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1229758003293	protein binding site [polypeptide binding]; other site
1229758003294	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1229758003295	putative substrate binding region [chemical binding]; other site
1229758003296	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1229758003297	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1229758003298	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1229758003299	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1229758003300	catalytic residue [active]
1229758003301	putative FPP diphosphate  binding site; other site
1229758003302	putative FPP binding hydrophobic cleft; other site
1229758003303	dimer interface [polypeptide binding]; other site
1229758003304	putative IPP diphosphate binding site; other site
1229758003305	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1229758003306	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1229758003307	glutaminase active site [active]
1229758003308	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1229758003309	dimer interface [polypeptide binding]; other site
1229758003310	active site
1229758003311	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1229758003312	dimer interface [polypeptide binding]; other site
1229758003313	active site
1229758003314	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1229758003315	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1229758003316	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1229758003317	active site
1229758003318	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1229758003319	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1229758003320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003321	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229758003322	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1229758003323	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1229758003324	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229758003325	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229758003326	diphosphomevalonate decarboxylase; Region: PLN02407
1229758003327	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1229758003328	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1229758003329	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1229758003330	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1229758003331	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1229758003332	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1229758003333	homotetramer interface [polypeptide binding]; other site
1229758003334	FMN binding site [chemical binding]; other site
1229758003335	homodimer contacts [polypeptide binding]; other site
1229758003336	putative active site [active]
1229758003337	putative substrate binding site [chemical binding]; other site
1229758003338	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1229758003339	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758003340	active site
1229758003341	adenylosuccinate lyase; Provisional; Region: PRK07492
1229758003342	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1229758003343	tetramer interface [polypeptide binding]; other site
1229758003344	active site
1229758003345	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1229758003346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003347	putative substrate translocation pore; other site
1229758003348	Predicted esterase [General function prediction only]; Region: COG0627
1229758003349	S-formylglutathione hydrolase; Region: PLN02442
1229758003350	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1229758003351	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1229758003352	Potassium binding sites [ion binding]; other site
1229758003353	Cesium cation binding sites [ion binding]; other site
1229758003354	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1229758003355	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1229758003356	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1229758003357	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1229758003358	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1229758003359	putative active site [active]
1229758003360	nucleotide binding site [chemical binding]; other site
1229758003361	nudix motif; other site
1229758003362	putative metal binding site [ion binding]; other site
1229758003363	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1229758003364	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1229758003365	purine monophosphate binding site [chemical binding]; other site
1229758003366	dimer interface [polypeptide binding]; other site
1229758003367	putative catalytic residues [active]
1229758003368	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1229758003369	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1229758003370	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1229758003371	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1229758003372	active site
1229758003373	substrate binding site [chemical binding]; other site
1229758003374	cosubstrate binding site; other site
1229758003375	catalytic site [active]
1229758003376	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1229758003377	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1229758003378	dimerization interface [polypeptide binding]; other site
1229758003379	putative ATP binding site [chemical binding]; other site
1229758003380	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1229758003381	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1229758003382	active site
1229758003383	tetramer interface [polypeptide binding]; other site
1229758003384	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758003385	active site
1229758003386	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1229758003387	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1229758003388	dimerization interface [polypeptide binding]; other site
1229758003389	ATP binding site [chemical binding]; other site
1229758003390	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1229758003391	dimerization interface [polypeptide binding]; other site
1229758003392	ATP binding site [chemical binding]; other site
1229758003393	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1229758003394	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1229758003395	putative active site [active]
1229758003396	catalytic triad [active]
1229758003397	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1229758003398	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1229758003399	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1229758003400	ATP binding site [chemical binding]; other site
1229758003401	active site
1229758003402	substrate binding site [chemical binding]; other site
1229758003403	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1229758003404	ATP-grasp domain; Region: ATP-grasp; pfam02222
1229758003405	AIR carboxylase; Region: AIRC; pfam00731
1229758003406	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758003407	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758003408	substrate binding pocket [chemical binding]; other site
1229758003409	membrane-bound complex binding site; other site
1229758003410	hinge residues; other site
1229758003411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758003412	dimer interface [polypeptide binding]; other site
1229758003413	conserved gate region; other site
1229758003414	ABC-ATPase subunit interface; other site
1229758003415	cell division protein GpsB; Provisional; Region: PRK14127
1229758003416	DivIVA domain; Region: DivI1A_domain; TIGR03544
1229758003417	hypothetical protein; Provisional; Region: PRK13660
1229758003418	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1229758003419	Transglycosylase; Region: Transgly; pfam00912
1229758003420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1229758003421	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1229758003422	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1229758003423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758003424	Coenzyme A binding pocket [chemical binding]; other site
1229758003425	GMP synthase; Reviewed; Region: guaA; PRK00074
1229758003426	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1229758003427	AMP/PPi binding site [chemical binding]; other site
1229758003428	candidate oxyanion hole; other site
1229758003429	catalytic triad [active]
1229758003430	potential glutamine specificity residues [chemical binding]; other site
1229758003431	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1229758003432	ATP Binding subdomain [chemical binding]; other site
1229758003433	Dimerization subdomain; other site
1229758003434	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
1229758003435	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1229758003436	phosphate binding site [ion binding]; other site
1229758003437	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
1229758003438	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1229758003439	active site
1229758003440	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758003441	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1229758003442	NlpC/P60 family; Region: NLPC_P60; pfam00877
1229758003443	heat shock protein HtpX; Provisional; Region: PRK04897
1229758003444	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1229758003445	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1229758003446	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1229758003447	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1229758003448	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1229758003449	HIGH motif; other site
1229758003450	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229758003451	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1229758003452	active site
1229758003453	KMSKS motif; other site
1229758003454	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1229758003455	tRNA binding surface [nucleotide binding]; other site
1229758003456	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1229758003457	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1229758003458	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1229758003459	active site
1229758003460	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1229758003461	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1229758003462	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
1229758003463	active site
1229758003464	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229758003465	Ligand Binding Site [chemical binding]; other site
1229758003466	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1229758003467	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229758003468	active site
1229758003469	dimer interface [polypeptide binding]; other site
1229758003470	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229758003471	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229758003472	Walker A/P-loop; other site
1229758003473	ATP binding site [chemical binding]; other site
1229758003474	Q-loop/lid; other site
1229758003475	ABC transporter signature motif; other site
1229758003476	Walker B; other site
1229758003477	D-loop; other site
1229758003478	H-loop/switch region; other site
1229758003479	elongation factor Tu; Reviewed; Region: PRK00049
1229758003480	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1229758003481	G1 box; other site
1229758003482	GEF interaction site [polypeptide binding]; other site
1229758003483	GTP/Mg2+ binding site [chemical binding]; other site
1229758003484	Switch I region; other site
1229758003485	G2 box; other site
1229758003486	G3 box; other site
1229758003487	Switch II region; other site
1229758003488	G4 box; other site
1229758003489	G5 box; other site
1229758003490	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1229758003491	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1229758003492	Antibiotic Binding Site [chemical binding]; other site
1229758003493	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1229758003494	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1229758003495	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1229758003496	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1229758003497	23S rRNA binding site [nucleotide binding]; other site
1229758003498	L21 binding site [polypeptide binding]; other site
1229758003499	L13 binding site [polypeptide binding]; other site
1229758003500	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1229758003501	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1229758003502	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1229758003503	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1229758003504	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
1229758003505	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1229758003506	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1229758003507	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1229758003508	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229758003509	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1229758003510	active site
1229758003511	dimer interface [polypeptide binding]; other site
1229758003512	motif 1; other site
1229758003513	motif 2; other site
1229758003514	motif 3; other site
1229758003515	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1229758003516	anticodon binding site; other site
1229758003517	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1229758003518	amphipathic channel; other site
1229758003519	Asn-Pro-Ala signature motifs; other site
1229758003520	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1229758003521	hypothetical protein; Validated; Region: PRK00110
1229758003522	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1229758003523	tetramer interfaces [polypeptide binding]; other site
1229758003524	binuclear metal-binding site [ion binding]; other site
1229758003525	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1229758003526	putative ligand binding site [chemical binding]; other site
1229758003527	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229758003528	putative NAD binding site [chemical binding]; other site
1229758003529	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1229758003530	L-serine binding site [chemical binding]; other site
1229758003531	ACT domain interface; other site
1229758003532	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1229758003533	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1229758003534	catalytic residue [active]
1229758003535	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1229758003536	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1229758003537	ligand binding site [chemical binding]; other site
1229758003538	active site
1229758003539	UGI interface [polypeptide binding]; other site
1229758003540	catalytic site [active]
1229758003541	Tubby C 2; Region: Tub_2; cl02043
1229758003542	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1229758003543	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1229758003544	THF binding site; other site
1229758003545	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1229758003546	substrate binding site [chemical binding]; other site
1229758003547	THF binding site; other site
1229758003548	zinc-binding site [ion binding]; other site
1229758003549	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1229758003550	FAD binding site [chemical binding]; other site
1229758003551	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1229758003552	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1229758003553	Walker A/P-loop; other site
1229758003554	ATP binding site [chemical binding]; other site
1229758003555	Q-loop/lid; other site
1229758003556	ABC transporter signature motif; other site
1229758003557	Walker B; other site
1229758003558	D-loop; other site
1229758003559	H-loop/switch region; other site
1229758003560	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1229758003561	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1229758003562	Walker A/P-loop; other site
1229758003563	ATP binding site [chemical binding]; other site
1229758003564	Q-loop/lid; other site
1229758003565	ABC transporter signature motif; other site
1229758003566	Walker B; other site
1229758003567	D-loop; other site
1229758003568	H-loop/switch region; other site
1229758003569	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1229758003570	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1229758003571	TM-ABC transporter signature motif; other site
1229758003572	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229758003573	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1229758003574	TM-ABC transporter signature motif; other site
1229758003575	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1229758003576	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1229758003577	putative ligand binding site [chemical binding]; other site
1229758003578	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1229758003579	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229758003580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758003581	active site
1229758003582	potential frameshift: common BLAST hit: gi|296110591|ref|YP_003620972.1| branched-chain amino acid transporter
1229758003583	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1229758003584	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1229758003585	Predicted membrane protein [Function unknown]; Region: COG4684
1229758003586	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
1229758003587	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229758003588	active site
1229758003589	HIGH motif; other site
1229758003590	nucleotide binding site [chemical binding]; other site
1229758003591	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1229758003592	active site
1229758003593	KMSKS motif; other site
1229758003594	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1229758003595	tRNA binding surface [nucleotide binding]; other site
1229758003596	anticodon binding site; other site
1229758003597	DivIVA protein; Region: DivIVA; pfam05103
1229758003598	DivIVA domain; Region: DivI1A_domain; TIGR03544
1229758003599	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1229758003600	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758003601	RNA binding surface [nucleotide binding]; other site
1229758003602	YGGT family; Region: YGGT; pfam02325
1229758003603	Protein of unknown function (DUF552); Region: DUF552; cl00775
1229758003604	cell division protein FtsZ; Validated; Region: PRK09330
1229758003605	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1229758003606	nucleotide binding site [chemical binding]; other site
1229758003607	SulA interaction site; other site
1229758003608	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1229758003609	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229758003610	nucleotide binding site [chemical binding]; other site
1229758003611	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
1229758003612	Cell division protein FtsA; Region: FtsA; pfam14450
1229758003613	Cell division protein FtsQ; Region: FtsQ; pfam03799
1229758003614	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1229758003615	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1229758003616	active site
1229758003617	homodimer interface [polypeptide binding]; other site
1229758003618	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1229758003619	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758003620	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1229758003621	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1229758003622	Mg++ binding site [ion binding]; other site
1229758003623	putative catalytic motif [active]
1229758003624	putative substrate binding site [chemical binding]; other site
1229758003625	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1229758003626	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229758003627	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229758003628	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1229758003629	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1229758003630	Cell division protein FtsL; Region: FtsL; cl11433
1229758003631	MraW methylase family; Region: Methyltransf_5; cl17771
1229758003632	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1229758003633	cell division protein MraZ; Reviewed; Region: PRK00326
1229758003634	MraZ protein; Region: MraZ; pfam02381
1229758003635	MraZ protein; Region: MraZ; pfam02381
1229758003636	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
1229758003637	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1229758003638	DAK2 domain; Region: Dak2; pfam02734
1229758003639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1229758003640	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1229758003641	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758003642	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229758003643	catalytic residues [active]
1229758003644	Thiamine pyrophosphokinase; Region: TPK; cd07995
1229758003645	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1229758003646	active site
1229758003647	dimerization interface [polypeptide binding]; other site
1229758003648	thiamine binding site [chemical binding]; other site
1229758003649	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1229758003650	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1229758003651	substrate binding site [chemical binding]; other site
1229758003652	hexamer interface [polypeptide binding]; other site
1229758003653	metal binding site [ion binding]; metal-binding site
1229758003654	GTPase RsgA; Reviewed; Region: PRK00098
1229758003655	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1229758003656	RNA binding site [nucleotide binding]; other site
1229758003657	homodimer interface [polypeptide binding]; other site
1229758003658	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1229758003659	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1229758003660	GTP/Mg2+ binding site [chemical binding]; other site
1229758003661	G4 box; other site
1229758003662	G5 box; other site
1229758003663	G1 box; other site
1229758003664	Switch I region; other site
1229758003665	G2 box; other site
1229758003666	G3 box; other site
1229758003667	Switch II region; other site
1229758003668	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1229758003669	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1229758003670	active site
1229758003671	ATP binding site [chemical binding]; other site
1229758003672	substrate binding site [chemical binding]; other site
1229758003673	activation loop (A-loop); other site
1229758003674	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229758003675	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229758003676	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1229758003677	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1229758003678	active site
1229758003679	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1229758003680	NusB family; Region: NusB; pfam01029
1229758003681	putative RNA binding site [nucleotide binding]; other site
1229758003682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758003683	S-adenosylmethionine binding site [chemical binding]; other site
1229758003684	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1229758003685	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1229758003686	putative active site [active]
1229758003687	substrate binding site [chemical binding]; other site
1229758003688	putative cosubstrate binding site; other site
1229758003689	catalytic site [active]
1229758003690	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1229758003691	substrate binding site [chemical binding]; other site
1229758003692	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1229758003693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758003694	ATP binding site [chemical binding]; other site
1229758003695	putative Mg++ binding site [ion binding]; other site
1229758003696	nucleotide binding region [chemical binding]; other site
1229758003697	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1229758003698	ATP-binding site [chemical binding]; other site
1229758003699	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1229758003700	G1 box; other site
1229758003701	GTP/Mg2+ binding site [chemical binding]; other site
1229758003702	Switch I region; other site
1229758003703	G2 box; other site
1229758003704	G3 box; other site
1229758003705	Switch II region; other site
1229758003706	G4 box; other site
1229758003707	G5 box; other site
1229758003708	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1229758003709	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1229758003710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758003711	Walker A motif; other site
1229758003712	ATP binding site [chemical binding]; other site
1229758003713	Walker B motif; other site
1229758003714	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229758003715	trigger factor; Provisional; Region: tig; PRK01490
1229758003716	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1229758003717	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1229758003718	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
1229758003719	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
1229758003720	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1229758003721	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229758003722	active site
1229758003723	nucleotide binding site [chemical binding]; other site
1229758003724	HIGH motif; other site
1229758003725	KMSKS motif; other site
1229758003726	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1229758003727	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1229758003728	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1229758003729	SelR domain; Region: SelR; pfam01641
1229758003730	dipeptidase PepV; Reviewed; Region: PRK07318
1229758003731	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1229758003732	active site
1229758003733	metal binding site [ion binding]; metal-binding site
1229758003734	CsbD-like; Region: CsbD; pfam05532
1229758003735	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1229758003736	putative substrate binding site [chemical binding]; other site
1229758003737	putative ATP binding site [chemical binding]; other site
1229758003738	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1229758003739	active site
1229758003740	putative catalytic site [active]
1229758003741	DNA binding site [nucleotide binding]
1229758003742	putative phosphate binding site [ion binding]; other site
1229758003743	metal binding site A [ion binding]; metal-binding site
1229758003744	AP binding site [nucleotide binding]; other site
1229758003745	metal binding site B [ion binding]; metal-binding site
1229758003746	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1229758003747	active site
1229758003748	catalytic site [active]
1229758003749	substrate binding site [chemical binding]; other site
1229758003750	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1229758003751	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1229758003752	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1229758003753	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1229758003754	active site
1229758003755	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1229758003756	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1229758003757	homodimer interface [polypeptide binding]; other site
1229758003758	NAD binding pocket [chemical binding]; other site
1229758003759	ATP binding pocket [chemical binding]; other site
1229758003760	Mg binding site [ion binding]; other site
1229758003761	active-site loop [active]
1229758003762	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1229758003763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758003764	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1229758003765	Walker A/P-loop; other site
1229758003766	ATP binding site [chemical binding]; other site
1229758003767	Q-loop/lid; other site
1229758003768	ABC transporter signature motif; other site
1229758003769	Walker B; other site
1229758003770	D-loop; other site
1229758003771	H-loop/switch region; other site
1229758003772	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758003773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758003774	non-specific DNA binding site [nucleotide binding]; other site
1229758003775	salt bridge; other site
1229758003776	sequence-specific DNA binding site [nucleotide binding]; other site
1229758003777	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1229758003778	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1229758003779	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1229758003780	protein binding site [polypeptide binding]; other site
1229758003781	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1229758003782	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1229758003783	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1229758003784	active site
1229758003785	(T/H)XGH motif; other site
1229758003786	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1229758003787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758003788	S-adenosylmethionine binding site [chemical binding]; other site
1229758003789	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
1229758003790	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1229758003791	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1229758003792	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1229758003793	oligomer interface [polypeptide binding]; other site
1229758003794	active site
1229758003795	metal binding site [ion binding]; metal-binding site
1229758003796	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758003797	catalytic core [active]
1229758003798	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758003799	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1229758003800	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1229758003801	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229758003802	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1229758003803	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229758003804	Walker A/P-loop; other site
1229758003805	ATP binding site [chemical binding]; other site
1229758003806	Q-loop/lid; other site
1229758003807	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1229758003808	ABC transporter signature motif; other site
1229758003809	Walker B; other site
1229758003810	D-loop; other site
1229758003811	H-loop/switch region; other site
1229758003812	Arginine repressor [Transcription]; Region: ArgR; COG1438
1229758003813	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1229758003814	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1229758003815	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1229758003816	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758003817	RNA binding surface [nucleotide binding]; other site
1229758003818	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1229758003819	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1229758003820	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1229758003821	substrate binding pocket [chemical binding]; other site
1229758003822	chain length determination region; other site
1229758003823	catalytic residues [active]
1229758003824	aspartate-rich region 1; other site
1229758003825	substrate-Mg2+ binding site; other site
1229758003826	active site lid residues [active]
1229758003827	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1229758003828	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1229758003829	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1229758003830	generic binding surface II; other site
1229758003831	generic binding surface I; other site
1229758003832	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1229758003833	putative dimer interface [polypeptide binding]; other site
1229758003834	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1229758003835	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1229758003836	putative dimer interface [polypeptide binding]; other site
1229758003837	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1229758003838	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1229758003839	nucleotide binding pocket [chemical binding]; other site
1229758003840	K-X-D-G motif; other site
1229758003841	catalytic site [active]
1229758003842	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1229758003843	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1229758003844	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1229758003845	Dimer interface [polypeptide binding]; other site
1229758003846	BRCT sequence motif; other site
1229758003847	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1229758003848	Part of AAA domain; Region: AAA_19; pfam13245
1229758003849	Family description; Region: UvrD_C_2; pfam13538
1229758003850	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1229758003851	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1229758003852	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229758003853	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1229758003854	Walker A/P-loop; other site
1229758003855	ATP binding site [chemical binding]; other site
1229758003856	Q-loop/lid; other site
1229758003857	ABC transporter signature motif; other site
1229758003858	Walker B; other site
1229758003859	D-loop; other site
1229758003860	H-loop/switch region; other site
1229758003861	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1229758003862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758003863	Walker A/P-loop; other site
1229758003864	ATP binding site [chemical binding]; other site
1229758003865	Q-loop/lid; other site
1229758003866	ABC transporter signature motif; other site
1229758003867	Walker B; other site
1229758003868	D-loop; other site
1229758003869	H-loop/switch region; other site
1229758003870	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1229758003871	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1229758003872	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1229758003873	hypothetical protein; Provisional; Region: PRK13678
1229758003874	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1229758003875	hypothetical protein; Provisional; Region: PRK05473
1229758003876	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1229758003877	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1229758003878	motif 1; other site
1229758003879	active site
1229758003880	motif 2; other site
1229758003881	motif 3; other site
1229758003882	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1229758003883	DHHA1 domain; Region: DHHA1; pfam02272
1229758003884	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
1229758003885	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229758003886	inhibitor-cofactor binding pocket; inhibition site
1229758003887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758003888	catalytic residue [active]
1229758003889	amino acid transporter; Region: 2A0306; TIGR00909
1229758003890	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1229758003891	GntP family permease; Region: GntP_permease; pfam02447
1229758003892	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1229758003893	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1229758003894	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1229758003895	N- and C-terminal domain interface [polypeptide binding]; other site
1229758003896	active site
1229758003897	catalytic site [active]
1229758003898	metal binding site [ion binding]; metal-binding site
1229758003899	carbohydrate binding site [chemical binding]; other site
1229758003900	ATP binding site [chemical binding]; other site
1229758003901	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1229758003902	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1229758003903	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1229758003904	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1229758003905	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1229758003906	putative active site [active]
1229758003907	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1229758003908	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1229758003909	Sugar specificity; other site
1229758003910	Pyrimidine base specificity; other site
1229758003911	ATP-binding site [chemical binding]; other site
1229758003912	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1229758003913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003914	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758003915	putative substrate translocation pore; other site
1229758003916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003917	putative substrate translocation pore; other site
1229758003918	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1229758003919	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1229758003920	catalytic triad [active]
1229758003921	catalytic triad [active]
1229758003922	oxyanion hole [active]
1229758003923	catabolite control protein A; Region: ccpA; TIGR01481
1229758003924	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758003925	DNA binding site [nucleotide binding]
1229758003926	domain linker motif; other site
1229758003927	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1229758003928	dimerization interface [polypeptide binding]; other site
1229758003929	effector binding site; other site
1229758003930	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1229758003931	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1229758003932	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1229758003933	active site
1229758003934	CAAX protease self-immunity; Region: Abi; pfam02517
1229758003935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758003936	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229758003937	active site
1229758003938	motif I; other site
1229758003939	motif II; other site
1229758003940	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229758003941	hypothetical protein; Provisional; Region: PRK04351
1229758003942	SprT homologues; Region: SprT; cl01182
1229758003943	acyl carrier protein; Provisional; Region: acpP; PRK00982
1229758003944	putative phosphate acyltransferase; Provisional; Region: PRK05331
1229758003945	putative transport protein YifK; Provisional; Region: PRK10746
1229758003946	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1229758003947	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1229758003948	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1229758003949	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758003950	Zn2+ binding site [ion binding]; other site
1229758003951	Mg2+ binding site [ion binding]; other site
1229758003952	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1229758003953	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696
1229758003954	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1229758003955	benzoate transport; Region: 2A0115; TIGR00895
1229758003956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003957	putative substrate translocation pore; other site
1229758003958	Peptidase family M1; Region: Peptidase_M1; pfam01433
1229758003959	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1229758003960	Zn binding site [ion binding]; other site
1229758003961	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
1229758003962	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1229758003963	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1229758003964	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1229758003965	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1229758003966	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1229758003967	active site
1229758003968	catalytic site [active]
1229758003969	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1229758003970	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758003971	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758003972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003973	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758003974	putative substrate translocation pore; other site
1229758003975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758003976	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758003977	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758003978	peroxiredoxin; Region: AhpC; TIGR03137
1229758003979	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1229758003980	dimer interface [polypeptide binding]; other site
1229758003981	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1229758003982	catalytic triad [active]
1229758003983	peroxidatic and resolving cysteines [active]
1229758003984	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
1229758003985	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758003986	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1229758003987	catalytic residue [active]
1229758003988	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1229758003989	catalytic residues [active]
1229758003990	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1229758003991	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1229758003992	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1229758003993	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758003994	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758003995	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1229758003996	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1229758003997	E3 interaction surface; other site
1229758003998	lipoyl attachment site [posttranslational modification]; other site
1229758003999	e3 binding domain; Region: E3_binding; pfam02817
1229758004000	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1229758004001	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1229758004002	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1229758004003	alpha subunit interface [polypeptide binding]; other site
1229758004004	TPP binding site [chemical binding]; other site
1229758004005	heterodimer interface [polypeptide binding]; other site
1229758004006	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1229758004007	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1229758004008	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1229758004009	tetramer interface [polypeptide binding]; other site
1229758004010	TPP-binding site [chemical binding]; other site
1229758004011	heterodimer interface [polypeptide binding]; other site
1229758004012	phosphorylation loop region [posttranslational modification]
1229758004013	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1229758004014	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1229758004015	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1229758004016	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1229758004017	active site residue [active]
1229758004018	adaptor protein; Provisional; Region: PRK02315
1229758004019	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1229758004020	ArsC family; Region: ArsC; pfam03960
1229758004021	putative catalytic residues [active]
1229758004022	thiol/disulfide switch; other site
1229758004023	general stress protein 13; Validated; Region: PRK08059
1229758004024	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
1229758004025	RNA binding site [nucleotide binding]; other site
1229758004026	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1229758004027	active site
1229758004028	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1229758004029	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1229758004030	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1229758004031	catalytic site [active]
1229758004032	G-X2-G-X-G-K; other site
1229758004033	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1229758004034	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1229758004035	phosphodiesterase; Provisional; Region: PRK12704
1229758004036	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758004037	Zn2+ binding site [ion binding]; other site
1229758004038	Mg2+ binding site [ion binding]; other site
1229758004039	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1229758004040	SmpB-tmRNA interface; other site
1229758004041	ribonuclease R; Region: RNase_R; TIGR02063
1229758004042	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1229758004043	RNB domain; Region: RNB; pfam00773
1229758004044	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1229758004045	RNA binding site [nucleotide binding]; other site
1229758004046	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1229758004047	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1229758004048	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1229758004049	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1229758004050	OxaA-like protein precursor; Provisional; Region: PRK02463
1229758004051	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1229758004052	Acylphosphatase; Region: Acylphosphatase; pfam00708
1229758004053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229758004054	HAMP domain; Region: HAMP; pfam00672
1229758004055	dimerization interface [polypeptide binding]; other site
1229758004056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229758004057	dimer interface [polypeptide binding]; other site
1229758004058	phosphorylation site [posttranslational modification]
1229758004059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758004060	ATP binding site [chemical binding]; other site
1229758004061	Mg2+ binding site [ion binding]; other site
1229758004062	G-X-G motif; other site
1229758004063	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758004064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758004065	active site
1229758004066	phosphorylation site [posttranslational modification]
1229758004067	intermolecular recognition site; other site
1229758004068	dimerization interface [polypeptide binding]; other site
1229758004069	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758004070	DNA binding site [nucleotide binding]
1229758004071	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1229758004072	hypothetical protein; Provisional; Region: PRK13670
1229758004073	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1229758004074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758004075	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1229758004076	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758004077	Zn2+ binding site [ion binding]; other site
1229758004078	Mg2+ binding site [ion binding]; other site
1229758004079	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1229758004080	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1229758004081	active site
1229758004082	(T/H)XGH motif; other site
1229758004083	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1229758004084	GTPase YqeH; Provisional; Region: PRK13796
1229758004085	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1229758004086	GTP/Mg2+ binding site [chemical binding]; other site
1229758004087	G4 box; other site
1229758004088	G5 box; other site
1229758004089	G1 box; other site
1229758004090	Switch I region; other site
1229758004091	G2 box; other site
1229758004092	G3 box; other site
1229758004093	Switch II region; other site
1229758004094	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1229758004095	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758004096	active site
1229758004097	motif I; other site
1229758004098	motif II; other site
1229758004099	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1229758004100	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1229758004101	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1229758004102	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
1229758004103	homodimer interface [polypeptide binding]; other site
1229758004104	ligand binding site [chemical binding]; other site
1229758004105	NAD binding site [chemical binding]; other site
1229758004106	catalytic site [active]
1229758004107	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1229758004108	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1229758004109	oligomer interface [polypeptide binding]; other site
1229758004110	active site residues [active]
1229758004111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1229758004112	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1229758004113	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1229758004114	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1229758004115	phosphate binding site [ion binding]; other site
1229758004116	putative substrate binding pocket [chemical binding]; other site
1229758004117	dimer interface [polypeptide binding]; other site
1229758004118	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1229758004119	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229758004120	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1229758004121	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1229758004122	excinuclease ABC subunit B; Provisional; Region: PRK05298
1229758004123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758004124	ATP binding site [chemical binding]; other site
1229758004125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758004126	nucleotide binding region [chemical binding]; other site
1229758004127	ATP-binding site [chemical binding]; other site
1229758004128	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1229758004129	UvrB/uvrC motif; Region: UVR; pfam02151
1229758004130	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1229758004131	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1229758004132	Sulfatase; Region: Sulfatase; pfam00884
1229758004133	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
1229758004134	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1229758004135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758004136	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1229758004137	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1229758004138	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1229758004139	putative ADP-binding pocket [chemical binding]; other site
1229758004140	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229758004141	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229758004142	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758004143	Walker A/P-loop; other site
1229758004144	ATP binding site [chemical binding]; other site
1229758004145	Q-loop/lid; other site
1229758004146	ABC transporter signature motif; other site
1229758004147	Walker B; other site
1229758004148	D-loop; other site
1229758004149	H-loop/switch region; other site
1229758004150	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1229758004151	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1229758004152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758004153	Walker A/P-loop; other site
1229758004154	ATP binding site [chemical binding]; other site
1229758004155	Q-loop/lid; other site
1229758004156	ABC transporter signature motif; other site
1229758004157	Walker B; other site
1229758004158	D-loop; other site
1229758004159	H-loop/switch region; other site
1229758004160	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229758004161	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229758004162	Walker A/P-loop; other site
1229758004163	ATP binding site [chemical binding]; other site
1229758004164	Q-loop/lid; other site
1229758004165	ABC transporter signature motif; other site
1229758004166	Walker B; other site
1229758004167	D-loop; other site
1229758004168	H-loop/switch region; other site
1229758004169	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1229758004170	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229758004171	FtsX-like permease family; Region: FtsX; pfam02687
1229758004172	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1229758004173	Zn2+ binding site [ion binding]; other site
1229758004174	Mg2+ binding site [ion binding]; other site
1229758004175	Preprotein translocase subunit; Region: YajC; cl00806
1229758004176	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1229758004177	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1229758004178	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1229758004179	dimerization domain swap beta strand [polypeptide binding]; other site
1229758004180	regulatory protein interface [polypeptide binding]; other site
1229758004181	active site
1229758004182	regulatory phosphorylation site [posttranslational modification]; other site
1229758004183	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1229758004184	MPN+ (JAMM) motif; other site
1229758004185	Zinc-binding site [ion binding]; other site
1229758004186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758004188	putative substrate translocation pore; other site
1229758004189	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1229758004190	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758004191	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229758004192	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1229758004193	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229758004194	ATP binding site [chemical binding]; other site
1229758004195	Mg++ binding site [ion binding]; other site
1229758004196	motif III; other site
1229758004197	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758004198	nucleotide binding region [chemical binding]; other site
1229758004199	ATP-binding site [chemical binding]; other site
1229758004200	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1229758004201	Beta-lactamase; Region: Beta-lactamase; pfam00144
1229758004202	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1229758004203	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1229758004204	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1229758004205	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1229758004206	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1229758004207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758004208	S-adenosylmethionine binding site [chemical binding]; other site
1229758004209	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1229758004210	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1229758004211	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1229758004212	hinge; other site
1229758004213	active site
1229758004214	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1229758004215	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1229758004216	putative tRNA-binding site [nucleotide binding]; other site
1229758004217	B3/4 domain; Region: B3_4; pfam03483
1229758004218	tRNA synthetase B5 domain; Region: B5; smart00874
1229758004219	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1229758004220	dimer interface [polypeptide binding]; other site
1229758004221	motif 1; other site
1229758004222	motif 3; other site
1229758004223	motif 2; other site
1229758004224	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1229758004225	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1229758004226	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1229758004227	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1229758004228	dimer interface [polypeptide binding]; other site
1229758004229	motif 1; other site
1229758004230	active site
1229758004231	motif 2; other site
1229758004232	motif 3; other site
1229758004233	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229758004234	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1229758004235	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1229758004236	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1229758004237	nucleotide binding site [chemical binding]; other site
1229758004238	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1229758004239	active site
1229758004240	metal binding site [ion binding]; metal-binding site
1229758004241	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
1229758004242	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1229758004243	putative NAD(P) binding site [chemical binding]; other site
1229758004244	catalytic Zn binding site [ion binding]; other site
1229758004245	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758004246	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758004247	DNA binding site [nucleotide binding]
1229758004248	domain linker motif; other site
1229758004249	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1229758004250	dimerization interface [polypeptide binding]; other site
1229758004251	ligand binding site [chemical binding]; other site
1229758004252	sodium binding site [ion binding]; other site
1229758004253	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1229758004254	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
1229758004255	putative ligand binding site [chemical binding]; other site
1229758004256	putative NAD binding site [chemical binding]; other site
1229758004257	catalytic site [active]
1229758004258	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1229758004259	active site
1229758004260	catalytic motif [active]
1229758004261	Zn binding site [ion binding]; other site
1229758004262	oligoendopeptidase F; Region: pepF; TIGR00181
1229758004263	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1229758004264	active site
1229758004265	Zn binding site [ion binding]; other site
1229758004266	Competence protein CoiA-like family; Region: CoiA; cl11541
1229758004267	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758004268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758004269	substrate binding pocket [chemical binding]; other site
1229758004270	membrane-bound complex binding site; other site
1229758004271	hinge residues; other site
1229758004272	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229758004273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758004274	dimer interface [polypeptide binding]; other site
1229758004275	conserved gate region; other site
1229758004276	putative PBP binding loops; other site
1229758004277	ABC-ATPase subunit interface; other site
1229758004278	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229758004279	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229758004280	Walker A/P-loop; other site
1229758004281	ATP binding site [chemical binding]; other site
1229758004282	Q-loop/lid; other site
1229758004283	ABC transporter signature motif; other site
1229758004284	Walker B; other site
1229758004285	D-loop; other site
1229758004286	H-loop/switch region; other site
1229758004287	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758004288	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758004289	substrate binding pocket [chemical binding]; other site
1229758004290	membrane-bound complex binding site; other site
1229758004291	hinge residues; other site
1229758004292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758004293	dimer interface [polypeptide binding]; other site
1229758004294	conserved gate region; other site
1229758004295	putative PBP binding loops; other site
1229758004296	ABC-ATPase subunit interface; other site
1229758004297	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1229758004298	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1229758004299	ligand binding site [chemical binding]; other site
1229758004300	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
1229758004301	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
1229758004302	YibE/F-like protein; Region: YibE_F; pfam07907
1229758004303	YibE/F-like protein; Region: YibE_F; pfam07907
1229758004304	primosomal protein DnaI; Reviewed; Region: PRK08939
1229758004305	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1229758004306	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229758004307	Walker A motif; other site
1229758004308	ATP binding site [chemical binding]; other site
1229758004309	Walker B motif; other site
1229758004310	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1229758004311	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1229758004312	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1229758004313	CoA-binding site [chemical binding]; other site
1229758004314	ATP-binding [chemical binding]; other site
1229758004315	Protein of unknown function (DUF975); Region: DUF975; cl10504
1229758004316	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1229758004317	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1229758004318	DNA binding site [nucleotide binding]
1229758004319	catalytic residue [active]
1229758004320	H2TH interface [polypeptide binding]; other site
1229758004321	putative catalytic residues [active]
1229758004322	turnover-facilitating residue; other site
1229758004323	intercalation triad [nucleotide binding]; other site
1229758004324	8OG recognition residue [nucleotide binding]; other site
1229758004325	putative reading head residues; other site
1229758004326	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1229758004327	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1229758004328	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1229758004329	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1229758004330	MutS domain III; Region: MutS_III; pfam05192
1229758004331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758004332	Walker A/P-loop; other site
1229758004333	ATP binding site [chemical binding]; other site
1229758004334	Q-loop/lid; other site
1229758004335	ABC transporter signature motif; other site
1229758004336	Walker B; other site
1229758004337	D-loop; other site
1229758004338	H-loop/switch region; other site
1229758004339	Smr domain; Region: Smr; pfam01713
1229758004340	Colicin V production protein; Region: Colicin_V; pfam02674
1229758004341	Cell division protein ZapA; Region: ZapA; cl01146
1229758004342	ribonuclease HIII; Provisional; Region: PRK00996
1229758004343	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1229758004344	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1229758004345	RNA/DNA hybrid binding site [nucleotide binding]; other site
1229758004346	active site
1229758004347	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1229758004348	Predicted flavoprotein [General function prediction only]; Region: COG0431
1229758004349	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1229758004350	thiamine phosphate binding site [chemical binding]; other site
1229758004351	active site
1229758004352	pyrophosphate binding site [ion binding]; other site
1229758004353	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1229758004354	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1229758004355	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229758004356	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229758004357	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229758004358	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1229758004359	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1229758004360	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229758004361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758004362	NAD(P) binding site [chemical binding]; other site
1229758004363	active site
1229758004364	TspO/MBR family; Region: TspO_MBR; pfam03073
1229758004365	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1229758004366	putative uracil binding site [chemical binding]; other site
1229758004367	putative active site [active]
1229758004368	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1229758004369	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1229758004370	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1229758004371	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1229758004372	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1229758004373	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1229758004374	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1229758004375	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1229758004376	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1229758004377	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1229758004378	carboxyltransferase (CT) interaction site; other site
1229758004379	biotinylation site [posttranslational modification]; other site
1229758004380	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1229758004381	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1229758004382	dimer interface [polypeptide binding]; other site
1229758004383	active site
1229758004384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758004385	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1229758004386	NAD(P) binding site [chemical binding]; other site
1229758004387	active site
1229758004388	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1229758004389	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1229758004390	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1229758004391	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1229758004392	FMN binding site [chemical binding]; other site
1229758004393	substrate binding site [chemical binding]; other site
1229758004394	putative catalytic residue [active]
1229758004395	acyl carrier protein; Provisional; Region: acpP; PRK00982
1229758004396	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1229758004397	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229758004398	dimer interface [polypeptide binding]; other site
1229758004399	active site
1229758004400	CoA binding pocket [chemical binding]; other site
1229758004401	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1229758004402	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758004403	putative Zn2+ binding site [ion binding]; other site
1229758004404	putative DNA binding site [nucleotide binding]; other site
1229758004405	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1229758004406	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1229758004407	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
1229758004408	active site
1229758004409	metal binding site [ion binding]; metal-binding site
1229758004410	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1229758004411	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1229758004412	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1229758004413	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1229758004414	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1229758004415	active site
1229758004416	HIGH motif; other site
1229758004417	KMSKS motif; other site
1229758004418	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1229758004419	tRNA binding surface [nucleotide binding]; other site
1229758004420	anticodon binding site; other site
1229758004421	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1229758004422	dimer interface [polypeptide binding]; other site
1229758004423	putative tRNA-binding site [nucleotide binding]; other site
1229758004424	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1229758004425	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1229758004426	Predicted membrane protein [Function unknown]; Region: COG4640
1229758004427	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1229758004428	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758004429	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758004430	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1229758004431	active site
1229758004432	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1229758004433	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1229758004434	putative catalytic cysteine [active]
1229758004435	gamma-glutamyl kinase; Provisional; Region: PRK05429
1229758004436	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1229758004437	nucleotide binding site [chemical binding]; other site
1229758004438	homotetrameric interface [polypeptide binding]; other site
1229758004439	putative phosphate binding site [ion binding]; other site
1229758004440	putative allosteric binding site; other site
1229758004441	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1229758004442	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229758004443	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1229758004444	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1229758004445	active site
1229758004446	Zn binding site [ion binding]; other site
1229758004447	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1229758004448	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229758004449	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1229758004450	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1229758004451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758004452	NAD(P) binding site [chemical binding]; other site
1229758004453	active site
1229758004454	Domain of unknown function (DUF368); Region: DUF368; cl00893
1229758004455	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1229758004456	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1229758004457	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1229758004458	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1229758004459	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1229758004460	Predicted membrane protein [Function unknown]; Region: COG4709
1229758004461	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229758004462	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229758004463	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1229758004464	thiamine phosphate binding site [chemical binding]; other site
1229758004465	active site
1229758004466	pyrophosphate binding site [ion binding]; other site
1229758004467	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229758004468	dimer interface [polypeptide binding]; other site
1229758004469	substrate binding site [chemical binding]; other site
1229758004470	ATP binding site [chemical binding]; other site
1229758004471	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1229758004472	substrate binding site [chemical binding]; other site
1229758004473	multimerization interface [polypeptide binding]; other site
1229758004474	ATP binding site [chemical binding]; other site
1229758004475	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
1229758004476	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1229758004477	metal ion-dependent adhesion site (MIDAS); other site
1229758004478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1229758004479	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758004480	Walker A motif; other site
1229758004481	ATP binding site [chemical binding]; other site
1229758004482	Walker B motif; other site
1229758004483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1229758004484	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229758004485	NAD(P) binding site [chemical binding]; other site
1229758004486	active site
1229758004487	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1229758004488	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1229758004489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1229758004490	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1229758004491	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1229758004492	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1229758004493	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1229758004494	Sugar transport protein; Region: Sugar_transport; pfam06800
1229758004495	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
1229758004496	dimerization interface [polypeptide binding]; other site
1229758004497	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1229758004498	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1229758004499	propionate/acetate kinase; Provisional; Region: PRK12379
1229758004500	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1229758004501	hypothetical protein; Provisional; Region: PRK10506
1229758004502	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1229758004503	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229758004504	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1229758004505	Type II/IV secretion system protein; Region: T2SE; pfam00437
1229758004506	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229758004507	Walker A motif; other site
1229758004508	ATP binding site [chemical binding]; other site
1229758004509	Walker B motif; other site
1229758004510	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1229758004511	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1229758004512	active site
1229758004513	dimer interface [polypeptide binding]; other site
1229758004514	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1229758004515	dimer interface [polypeptide binding]; other site
1229758004516	active site
1229758004517	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1229758004518	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1229758004519	active site
1229758004520	trimer interface [polypeptide binding]; other site
1229758004521	allosteric site; other site
1229758004522	active site lid [active]
1229758004523	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1229758004524	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229758004525	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1229758004526	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1229758004527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229758004528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229758004529	dimer interface [polypeptide binding]; other site
1229758004530	phosphorylation site [posttranslational modification]
1229758004531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758004532	ATP binding site [chemical binding]; other site
1229758004533	Mg2+ binding site [ion binding]; other site
1229758004534	G-X-G motif; other site
1229758004535	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758004536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758004537	active site
1229758004538	phosphorylation site [posttranslational modification]
1229758004539	intermolecular recognition site; other site
1229758004540	dimerization interface [polypeptide binding]; other site
1229758004541	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758004542	DNA binding site [nucleotide binding]
1229758004543	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
1229758004544	GTP-binding protein YchF; Reviewed; Region: PRK09601
1229758004545	YchF GTPase; Region: YchF; cd01900
1229758004546	G1 box; other site
1229758004547	GTP/Mg2+ binding site [chemical binding]; other site
1229758004548	Switch I region; other site
1229758004549	G2 box; other site
1229758004550	Switch II region; other site
1229758004551	G3 box; other site
1229758004552	G4 box; other site
1229758004553	G5 box; other site
1229758004554	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1229758004555	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1229758004556	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1229758004557	ParB-like nuclease domain; Region: ParB; smart00470
1229758004558	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229758004559	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758004560	P-loop; other site
1229758004561	Magnesium ion binding site [ion binding]; other site
1229758004562	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229758004563	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1229758004564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758004565	S-adenosylmethionine binding site [chemical binding]; other site
1229758004566	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758004567	dimerization interface [polypeptide binding]; other site
1229758004568	putative DNA binding site [nucleotide binding]; other site
1229758004569	putative Zn2+ binding site [ion binding]; other site
1229758004570	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1229758004571	Cadmium resistance transporter; Region: Cad; pfam03596
1229758004572	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229758004573	Ligand Binding Site [chemical binding]; other site
1229758004574	manganese transport protein MntH; Reviewed; Region: PRK00701
1229758004575	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1229758004576	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1229758004577	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1229758004578	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1229758004579	metal binding site [ion binding]; metal-binding site
1229758004580	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1229758004581	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1229758004582	ABC-ATPase subunit  interface; other site
1229758004583	dimer interface [polypeptide binding]; other site
1229758004584	putative PBP binding regions; other site
1229758004585	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1229758004586	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1229758004587	NAD-dependent deacetylase; Provisional; Region: PRK00481
1229758004588	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1229758004589	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1229758004590	homodimer interface [polypeptide binding]; other site
1229758004591	catalytic residues [active]
1229758004592	NAD binding site [chemical binding]; other site
1229758004593	substrate binding pocket [chemical binding]; other site
1229758004594	flexible flap; other site
1229758004595	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1229758004596	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1229758004597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1229758004598	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1229758004599	FemAB family; Region: FemAB; pfam02388
1229758004600	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758004601	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758004602	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1229758004603	NlpC/P60 family; Region: NLPC_P60; cl17555
1229758004604	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758004605	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1229758004606	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1229758004607	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1229758004608	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1229758004609	dimer interface [polypeptide binding]; other site
1229758004610	active site
1229758004611	CoA binding pocket [chemical binding]; other site
1229758004612	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1229758004613	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1229758004614	active site
1229758004615	HIGH motif; other site
1229758004616	nucleotide binding site [chemical binding]; other site
1229758004617	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1229758004618	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1229758004619	active site
1229758004620	KMSKS motif; other site
1229758004621	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1229758004622	tRNA binding surface [nucleotide binding]; other site
1229758004623	anticodon binding site; other site
1229758004624	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1229758004625	PemK-like protein; Region: PemK; pfam02452
1229758004626	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1229758004627	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1229758004628	active site
1229758004629	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1229758004630	dimer interface [polypeptide binding]; other site
1229758004631	substrate binding site [chemical binding]; other site
1229758004632	catalytic residues [active]
1229758004633	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1229758004634	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758004635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758004636	homodimer interface [polypeptide binding]; other site
1229758004637	catalytic residue [active]
1229758004638	Guanylate kinase; Region: Guanylate_kin; pfam00625
1229758004639	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1229758004640	active site
1229758004641	amino acid transporter; Region: 2A0306; TIGR00909
1229758004642	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1229758004643	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1229758004644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1229758004645	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1229758004646	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1229758004647	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1229758004648	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1229758004649	RNA binding surface [nucleotide binding]; other site
1229758004650	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
1229758004651	recombination factor protein RarA; Reviewed; Region: PRK13342
1229758004652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758004653	Walker A motif; other site
1229758004654	ATP binding site [chemical binding]; other site
1229758004655	Walker B motif; other site
1229758004656	arginine finger; other site
1229758004657	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1229758004658	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1229758004659	Ligand Binding Site [chemical binding]; other site
1229758004660	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758004661	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758004662	non-specific DNA binding site [nucleotide binding]; other site
1229758004663	salt bridge; other site
1229758004664	sequence-specific DNA binding site [nucleotide binding]; other site
1229758004665	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1229758004666	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1229758004667	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1229758004668	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1229758004669	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1229758004670	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1229758004671	rod shape-determining protein MreB; Provisional; Region: PRK13930
1229758004672	MreB and similar proteins; Region: MreB_like; cd10225
1229758004673	nucleotide binding site [chemical binding]; other site
1229758004674	Mg binding site [ion binding]; other site
1229758004675	putative protofilament interaction site [polypeptide binding]; other site
1229758004676	RodZ interaction site [polypeptide binding]; other site
1229758004677	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1229758004678	lysine transporter; Provisional; Region: PRK10836
1229758004679	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1229758004680	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1229758004681	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1229758004682	active site
1229758004683	HIGH motif; other site
1229758004684	dimer interface [polypeptide binding]; other site
1229758004685	KMSKS motif; other site
1229758004686	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1229758004687	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1229758004688	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1229758004689	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758004690	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
1229758004691	putative active site [active]
1229758004692	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229758004693	nudix motif; other site
1229758004694	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
1229758004695	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
1229758004696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758004697	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1229758004698	Walker A motif; other site
1229758004699	ATP binding site [chemical binding]; other site
1229758004700	Walker B motif; other site
1229758004701	arginine finger; other site
1229758004702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1229758004703	Walker A motif; other site
1229758004704	ATP binding site [chemical binding]; other site
1229758004705	Walker B motif; other site
1229758004706	arginine finger; other site
1229758004707	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1229758004708	TRAM domain; Region: TRAM; pfam01938
1229758004709	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1229758004710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1229758004711	S-adenosylmethionine binding site [chemical binding]; other site
1229758004712	hypothetical protein; Validated; Region: PRK07668
1229758004713	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229758004714	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229758004715	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1229758004716	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1229758004717	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1229758004718	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1229758004719	minor groove reading motif; other site
1229758004720	helix-hairpin-helix signature motif; other site
1229758004721	substrate binding pocket [chemical binding]; other site
1229758004722	active site
1229758004723	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1229758004724	DNA binding and oxoG recognition site [nucleotide binding]
1229758004725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004726	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758004727	putative substrate translocation pore; other site
1229758004728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004729	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1229758004730	dimer interface [polypeptide binding]; other site
1229758004731	substrate binding site [chemical binding]; other site
1229758004732	ATP binding site [chemical binding]; other site
1229758004733	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1229758004734	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1229758004735	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1229758004736	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1229758004737	protein binding site [polypeptide binding]; other site
1229758004738	YycH protein; Region: YycI; pfam09648
1229758004739	YycH protein; Region: YycH; pfam07435
1229758004740	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1229758004741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1229758004742	dimerization interface [polypeptide binding]; other site
1229758004743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1229758004744	putative active site [active]
1229758004745	heme pocket [chemical binding]; other site
1229758004746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1229758004747	dimer interface [polypeptide binding]; other site
1229758004748	phosphorylation site [posttranslational modification]
1229758004749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758004750	ATP binding site [chemical binding]; other site
1229758004751	Mg2+ binding site [ion binding]; other site
1229758004752	G-X-G motif; other site
1229758004753	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758004754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758004755	active site
1229758004756	phosphorylation site [posttranslational modification]
1229758004757	intermolecular recognition site; other site
1229758004758	dimerization interface [polypeptide binding]; other site
1229758004759	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758004760	DNA binding site [nucleotide binding]
1229758004761	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1229758004762	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1229758004763	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758004764	active site
1229758004765	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1229758004766	dimer interface [polypeptide binding]; other site
1229758004767	catalytic triad [active]
1229758004768	peroxidatic and resolving cysteines [active]
1229758004769	sugar phosphate phosphatase; Provisional; Region: PRK10513
1229758004770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758004771	active site
1229758004772	motif I; other site
1229758004773	motif II; other site
1229758004774	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758004775	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1229758004776	homotrimer interaction site [polypeptide binding]; other site
1229758004777	putative active site [active]
1229758004778	threonine dehydratase; Validated; Region: PRK08639
1229758004779	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1229758004780	tetramer interface [polypeptide binding]; other site
1229758004781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758004782	catalytic residue [active]
1229758004783	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229758004784	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1229758004785	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1229758004786	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1229758004787	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1229758004788	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
1229758004789	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1229758004790	PYR/PP interface [polypeptide binding]; other site
1229758004791	dimer interface [polypeptide binding]; other site
1229758004792	TPP binding site [chemical binding]; other site
1229758004793	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1229758004794	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1229758004795	TPP-binding site [chemical binding]; other site
1229758004796	dimer interface [polypeptide binding]; other site
1229758004797	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1229758004798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758004799	Walker A/P-loop; other site
1229758004800	ATP binding site [chemical binding]; other site
1229758004801	Q-loop/lid; other site
1229758004802	ABC transporter signature motif; other site
1229758004803	Walker B; other site
1229758004804	D-loop; other site
1229758004805	H-loop/switch region; other site
1229758004806	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1229758004807	nudix motif; other site
1229758004808	putative phosphoketolase; Provisional; Region: PRK05261
1229758004809	XFP N-terminal domain; Region: XFP_N; pfam09364
1229758004810	XFP C-terminal domain; Region: XFP_C; pfam09363
1229758004811	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1229758004812	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229758004813	DNA-binding site [nucleotide binding]; DNA binding site
1229758004814	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1229758004815	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1229758004816	putative deacylase active site [active]
1229758004817	replicative DNA helicase; Region: DnaB; TIGR00665
1229758004818	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1229758004819	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1229758004820	Walker A motif; other site
1229758004821	ATP binding site [chemical binding]; other site
1229758004822	Walker B motif; other site
1229758004823	DNA binding loops [nucleotide binding]
1229758004824	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1229758004825	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1229758004826	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1229758004827	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1229758004828	DHH family; Region: DHH; pfam01368
1229758004829	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1229758004830	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1229758004831	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1229758004832	dimer interface [polypeptide binding]; other site
1229758004833	ssDNA binding site [nucleotide binding]; other site
1229758004834	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229758004835	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1229758004836	dipeptidase PepV; Reviewed; Region: PRK07318
1229758004837	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1229758004838	active site
1229758004839	metal binding site [ion binding]; metal-binding site
1229758004840	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1229758004841	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1229758004842	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758004843	Walker A/P-loop; other site
1229758004844	ATP binding site [chemical binding]; other site
1229758004845	Q-loop/lid; other site
1229758004846	ABC transporter signature motif; other site
1229758004847	Walker B; other site
1229758004848	D-loop; other site
1229758004849	H-loop/switch region; other site
1229758004850	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1229758004851	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758004852	Walker A/P-loop; other site
1229758004853	ATP binding site [chemical binding]; other site
1229758004854	Q-loop/lid; other site
1229758004855	ABC transporter signature motif; other site
1229758004856	Walker B; other site
1229758004857	D-loop; other site
1229758004858	H-loop/switch region; other site
1229758004859	hypothetical protein; Provisional; Region: PRK13661
1229758004860	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1229758004861	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1229758004862	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1229758004863	NAD binding site [chemical binding]; other site
1229758004864	substrate binding site [chemical binding]; other site
1229758004865	catalytic Zn binding site [ion binding]; other site
1229758004866	tetramer interface [polypeptide binding]; other site
1229758004867	structural Zn binding site [ion binding]; other site
1229758004868	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1229758004869	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229758004870	active site
1229758004871	HIGH motif; other site
1229758004872	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1229758004873	active site
1229758004874	KMSKS motif; other site
1229758004875	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1229758004876	zinc binding site [ion binding]; other site
1229758004877	putative ligand binding site [chemical binding]; other site
1229758004878	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229758004879	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1229758004880	TM-ABC transporter signature motif; other site
1229758004881	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1229758004882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758004883	Walker A/P-loop; other site
1229758004884	ATP binding site [chemical binding]; other site
1229758004885	Q-loop/lid; other site
1229758004886	ABC transporter signature motif; other site
1229758004887	Walker B; other site
1229758004888	D-loop; other site
1229758004889	H-loop/switch region; other site
1229758004890	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1229758004891	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229758004892	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1229758004893	NAD binding site [chemical binding]; other site
1229758004894	dimer interface [polypeptide binding]; other site
1229758004895	substrate binding site [chemical binding]; other site
1229758004896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229758004897	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1229758004898	TM-ABC transporter signature motif; other site
1229758004899	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229758004900	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1229758004901	TM-ABC transporter signature motif; other site
1229758004902	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1229758004903	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229758004904	Walker A/P-loop; other site
1229758004905	ATP binding site [chemical binding]; other site
1229758004906	Q-loop/lid; other site
1229758004907	ABC transporter signature motif; other site
1229758004908	Walker B; other site
1229758004909	D-loop; other site
1229758004910	H-loop/switch region; other site
1229758004911	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229758004912	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1229758004913	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1229758004914	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1229758004915	TrkA-N domain; Region: TrkA_N; pfam02254
1229758004916	TrkA-C domain; Region: TrkA_C; pfam02080
1229758004917	D-lactate dehydrogenase; Provisional; Region: PRK11183
1229758004918	FAD binding domain; Region: FAD_binding_4; pfam01565
1229758004919	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1229758004920	OsmC-like protein; Region: OsmC; cl00767
1229758004921	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229758004922	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229758004923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004924	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758004925	putative substrate translocation pore; other site
1229758004926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004927	putative substrate translocation pore; other site
1229758004928	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1229758004929	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758004930	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758004931	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758004932	Predicted transcriptional regulator [Transcription]; Region: COG2378
1229758004933	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229758004934	substrate binding site [chemical binding]; other site
1229758004935	Predicted transcriptional regulators [Transcription]; Region: COG1695
1229758004936	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1229758004937	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1229758004938	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1229758004939	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1229758004940	heterotetramer interface [polypeptide binding]; other site
1229758004941	active site pocket [active]
1229758004942	cleavage site
1229758004943	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1229758004944	nucleotide binding site [chemical binding]; other site
1229758004945	N-acetyl-L-glutamate binding site [chemical binding]; other site
1229758004946	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1229758004947	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
1229758004948	inhibitor-cofactor binding pocket; inhibition site
1229758004949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758004950	catalytic residue [active]
1229758004951	conserved hypothetical protein; Region: TIGR02328
1229758004952	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1229758004953	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758004954	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758004955	non-specific DNA binding site [nucleotide binding]; other site
1229758004956	salt bridge; other site
1229758004957	sequence-specific DNA binding site [nucleotide binding]; other site
1229758004958	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1229758004959	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758004960	ATP binding site [chemical binding]; other site
1229758004961	putative Mg++ binding site [ion binding]; other site
1229758004962	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1229758004963	nucleotide binding region [chemical binding]; other site
1229758004964	ATP-binding site [chemical binding]; other site
1229758004965	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1229758004966	HRDC domain; Region: HRDC; pfam00570
1229758004967	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1229758004968	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1229758004969	catalytic core [active]
1229758004970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229758004971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229758004972	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1229758004973	dimerization interface [polypeptide binding]; other site
1229758004974	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1229758004975	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1229758004976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758004977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758004978	putative substrate translocation pore; other site
1229758004979	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1229758004980	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1229758004981	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1229758004982	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1229758004983	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1229758004984	active site
1229758004985	metal binding site [ion binding]; metal-binding site
1229758004986	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1229758004987	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1229758004988	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
1229758004989	Walker A/P-loop; other site
1229758004990	ATP binding site [chemical binding]; other site
1229758004991	Q-loop/lid; other site
1229758004992	ABC transporter signature motif; other site
1229758004993	Walker B; other site
1229758004994	D-loop; other site
1229758004995	H-loop/switch region; other site
1229758004996	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1229758004997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758004998	ATP binding site [chemical binding]; other site
1229758004999	Mg2+ binding site [ion binding]; other site
1229758005000	G-X-G motif; other site
1229758005001	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1229758005002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758005003	active site
1229758005004	phosphorylation site [posttranslational modification]
1229758005005	intermolecular recognition site; other site
1229758005006	dimerization interface [polypeptide binding]; other site
1229758005007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1229758005008	DNA binding site [nucleotide binding]
1229758005009	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1229758005010	FtsX-like permease family; Region: FtsX; pfam02687
1229758005011	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1229758005012	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1229758005013	Walker A/P-loop; other site
1229758005014	ATP binding site [chemical binding]; other site
1229758005015	Q-loop/lid; other site
1229758005016	ABC transporter signature motif; other site
1229758005017	Walker B; other site
1229758005018	D-loop; other site
1229758005019	H-loop/switch region; other site
1229758005020	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758005021	putative DNA binding site [nucleotide binding]; other site
1229758005022	putative Zn2+ binding site [ion binding]; other site
1229758005023	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1229758005024	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1229758005025	metal binding site [ion binding]; metal-binding site
1229758005026	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1229758005027	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1229758005028	active site
1229758005029	catalytic tetrad [active]
1229758005030	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1229758005031	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1229758005032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758005033	Walker A/P-loop; other site
1229758005034	ATP binding site [chemical binding]; other site
1229758005035	Q-loop/lid; other site
1229758005036	ABC transporter signature motif; other site
1229758005037	Walker B; other site
1229758005038	D-loop; other site
1229758005039	H-loop/switch region; other site
1229758005040	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1229758005041	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229758005042	Walker A/P-loop; other site
1229758005043	ATP binding site [chemical binding]; other site
1229758005044	Q-loop/lid; other site
1229758005045	ABC transporter signature motif; other site
1229758005046	Walker B; other site
1229758005047	D-loop; other site
1229758005048	H-loop/switch region; other site
1229758005049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1229758005050	DNA-binding site [nucleotide binding]; DNA binding site
1229758005051	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
1229758005052	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1229758005053	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1229758005054	ligand binding site [chemical binding]; other site
1229758005055	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
1229758005056	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1229758005057	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1229758005058	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1229758005059	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1229758005060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758005061	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1229758005062	active site
1229758005063	motif I; other site
1229758005064	motif II; other site
1229758005065	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1229758005066	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1229758005067	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1229758005068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1229758005069	active site
1229758005070	phosphorylation site [posttranslational modification]
1229758005071	intermolecular recognition site; other site
1229758005072	dimerization interface [polypeptide binding]; other site
1229758005073	LytTr DNA-binding domain; Region: LytTR; pfam04397
1229758005074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1229758005075	ATP binding site [chemical binding]; other site
1229758005076	Mg2+ binding site [ion binding]; other site
1229758005077	G-X-G motif; other site
1229758005078	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1229758005079	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1229758005080	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1229758005081	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1229758005082	active site
1229758005083	tetramer interface [polypeptide binding]; other site
1229758005084	CAAX protease self-immunity; Region: Abi; pfam02517
1229758005085	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1229758005086	HPr interaction site; other site
1229758005087	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1229758005088	active site
1229758005089	phosphorylation site [posttranslational modification]
1229758005090	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1229758005091	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1229758005092	substrate binding [chemical binding]; other site
1229758005093	active site
1229758005094	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1229758005095	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1229758005096	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1229758005097	active site turn [active]
1229758005098	phosphorylation site [posttranslational modification]
1229758005099	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1229758005100	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1229758005101	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229758005102	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1229758005103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1229758005104	hypothetical protein; Provisional; Region: PRK10281
1229758005105	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229758005106	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229758005107	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229758005108	catalytic residues [active]
1229758005109	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229758005110	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229758005111	Synaptic Site I dimer interface [polypeptide binding]; other site
1229758005112	DNA binding site [nucleotide binding]
1229758005113	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229758005114	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1229758005115	substrate binding site [chemical binding]; other site
1229758005116	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1229758005117	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1229758005118	putative NAD(P) binding site [chemical binding]; other site
1229758005119	dimer interface [polypeptide binding]; other site
1229758005120	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229758005121	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1229758005122	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1229758005123	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758005124	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758005125	non-specific DNA binding site [nucleotide binding]; other site
1229758005126	salt bridge; other site
1229758005127	sequence-specific DNA binding site [nucleotide binding]; other site
1229758005128	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229758005129	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1229758005130	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1229758005131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758005132	Walker A/P-loop; other site
1229758005133	ATP binding site [chemical binding]; other site
1229758005134	Q-loop/lid; other site
1229758005135	ABC transporter signature motif; other site
1229758005136	Walker B; other site
1229758005137	D-loop; other site
1229758005138	H-loop/switch region; other site
1229758005139	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758005140	dimerization interface [polypeptide binding]; other site
1229758005141	putative DNA binding site [nucleotide binding]; other site
1229758005142	putative Zn2+ binding site [ion binding]; other site
1229758005143	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1229758005144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1229758005145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1229758005146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1229758005147	dimerization interface [polypeptide binding]; other site
1229758005148	EamA-like transporter family; Region: EamA; pfam00892
1229758005149	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1229758005150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758005151	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229758005152	putative substrate translocation pore; other site
1229758005153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758005154	non-specific DNA binding site [nucleotide binding]; other site
1229758005155	salt bridge; other site
1229758005156	sequence-specific DNA binding site [nucleotide binding]; other site
1229758005157	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1229758005158	Mucin-like glycoprotein; Region: Mucin; pfam01456
1229758005159	Mucin-like glycoprotein; Region: Mucin; pfam01456
1229758005160	Mucin-like glycoprotein; Region: Mucin; pfam01456
1229758005161	Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324
1229758005162	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229758005163	active site
1229758005164	catalytic site [active]
1229758005165	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229758005166	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1229758005167	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005168	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005169	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005170	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005171	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005172	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005173	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005174	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005175	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005176	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005177	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1229758005178	Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324
1229758005179	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1229758005180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1229758005181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758005182	non-specific DNA binding site [nucleotide binding]; other site
1229758005183	salt bridge; other site
1229758005184	sequence-specific DNA binding site [nucleotide binding]; other site
1229758005185	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1229758005186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758005187	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1229758005188	putative substrate translocation pore; other site
1229758005189	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229758005190	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229758005191	Walker A/P-loop; other site
1229758005192	ATP binding site [chemical binding]; other site
1229758005193	Q-loop/lid; other site
1229758005194	ABC transporter signature motif; other site
1229758005195	Walker B; other site
1229758005196	D-loop; other site
1229758005197	H-loop/switch region; other site
1229758005198	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1229758005199	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1229758005200	NAD binding site [chemical binding]; other site
1229758005201	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1229758005202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1229758005203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1229758005204	homodimer interface [polypeptide binding]; other site
1229758005205	catalytic residue [active]
1229758005206	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1229758005207	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1229758005208	Walker A/P-loop; other site
1229758005209	ATP binding site [chemical binding]; other site
1229758005210	Q-loop/lid; other site
1229758005211	ABC transporter signature motif; other site
1229758005212	Walker B; other site
1229758005213	D-loop; other site
1229758005214	H-loop/switch region; other site
1229758005215	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1229758005216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758005217	dimer interface [polypeptide binding]; other site
1229758005218	conserved gate region; other site
1229758005219	putative PBP binding loops; other site
1229758005220	ABC-ATPase subunit interface; other site
1229758005221	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1229758005222	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1229758005223	substrate binding pocket [chemical binding]; other site
1229758005224	membrane-bound complex binding site; other site
1229758005225	hinge residues; other site
1229758005226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758005227	dimer interface [polypeptide binding]; other site
1229758005228	conserved gate region; other site
1229758005229	putative PBP binding loops; other site
1229758005230	ABC-ATPase subunit interface; other site
1229758005231	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1229758005232	CHAP domain; Region: CHAP; cl17642
1229758005233	Surface antigen [General function prediction only]; Region: COG3942
1229758005234	Predicted membrane protein [Function unknown]; Region: COG2261
1229758005235	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1229758005236	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1229758005237	active site
1229758005238	dimer interface [polypeptide binding]; other site
1229758005239	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1229758005240	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1229758005241	substrate binding site [chemical binding]; other site
1229758005242	dimer interface [polypeptide binding]; other site
1229758005243	ATP binding site [chemical binding]; other site
1229758005244	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1229758005245	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1229758005246	ligand binding site [chemical binding]; other site
1229758005247	dimerization interface [polypeptide binding]; other site
1229758005248	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1229758005249	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1229758005250	TM-ABC transporter signature motif; other site
1229758005251	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1229758005252	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1229758005253	Walker A/P-loop; other site
1229758005254	ATP binding site [chemical binding]; other site
1229758005255	Q-loop/lid; other site
1229758005256	ABC transporter signature motif; other site
1229758005257	Walker B; other site
1229758005258	D-loop; other site
1229758005259	H-loop/switch region; other site
1229758005260	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1229758005261	D-ribose pyranase; Provisional; Region: PRK11797
1229758005262	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1229758005263	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1229758005264	DNA binding site [nucleotide binding]
1229758005265	domain linker motif; other site
1229758005266	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1229758005267	dimerization interface [polypeptide binding]; other site
1229758005268	ligand binding site [chemical binding]; other site
1229758005269	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1229758005270	active site
1229758005271	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1229758005272	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1229758005273	Cl binding site [ion binding]; other site
1229758005274	oligomer interface [polypeptide binding]; other site
1229758005275	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1229758005276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1229758005277	Coenzyme A binding pocket [chemical binding]; other site
1229758005278	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1229758005279	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1229758005280	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1229758005281	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1229758005282	hypothetical protein; Provisional; Region: PRK12378
1229758005283	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1229758005284	pseudouridine synthase; Region: TIGR00093
1229758005285	probable active site [active]
1229758005286	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1229758005287	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229758005288	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005289	Magnesium ion binding site [ion binding]; other site
1229758005290	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1229758005291	Integrase core domain; Region: rve; pfam00665
1229758005292	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1229758005293	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758005294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758005295	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758005296	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1229758005297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758005298	Walker A/P-loop; other site
1229758005299	ATP binding site [chemical binding]; other site
1229758005300	Q-loop/lid; other site
1229758005301	ABC transporter signature motif; other site
1229758005302	Walker B; other site
1229758005303	D-loop; other site
1229758005304	H-loop/switch region; other site
1229758005305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1229758005306	dimer interface [polypeptide binding]; other site
1229758005307	conserved gate region; other site
1229758005308	ABC-ATPase subunit interface; other site
1229758005309	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1229758005310	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229758005311	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229758005312	catalytic residues [active]
1229758005313	catalytic nucleophile [active]
1229758005314	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229758005315	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229758005316	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229758005317	Synaptic Site I dimer interface [polypeptide binding]; other site
1229758005318	DNA binding site [nucleotide binding]
1229758005319	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758005320	catalytic residues [active]
1229758005321	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1229758005322	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1229758005323	NAD binding site [chemical binding]; other site
1229758005324	substrate binding site [chemical binding]; other site
1229758005325	putative active site [active]
1229758005326	Predicted transcriptional regulators [Transcription]; Region: COG1733
1229758005327	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1229758005328	putative DNA binding site [nucleotide binding]; other site
1229758005329	putative Zn2+ binding site [ion binding]; other site
1229758005330	potential frameshift: common BLAST hit: gi|254557662|ref|YP_003064079.1| GTP-binding protein LepA
1229758005331	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1229758005332	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1229758005333	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1229758005334	putative homodimer interface [polypeptide binding]; other site
1229758005335	putative homotetramer interface [polypeptide binding]; other site
1229758005336	putative metal binding site [ion binding]; other site
1229758005337	putative homodimer-homodimer interface [polypeptide binding]; other site
1229758005338	putative allosteric switch controlling residues; other site
1229758005339	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1229758005340	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1229758005341	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758005342	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758005343	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
1229758005344	active site residue [active]
1229758005345	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758005346	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1229758005347	catalytic residues [active]
1229758005348	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1229758005349	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1229758005350	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1229758005351	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1229758005352	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1229758005353	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1229758005354	Walker A/P-loop; other site
1229758005355	ATP binding site [chemical binding]; other site
1229758005356	Q-loop/lid; other site
1229758005357	ABC transporter signature motif; other site
1229758005358	Walker B; other site
1229758005359	D-loop; other site
1229758005360	H-loop/switch region; other site
1229758005361	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229758005362	Integrase core domain; Region: rve; pfam00665
1229758005363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1229758005364	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229758005365	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229758005366	catalytic residues [active]
1229758005367	catalytic nucleophile [active]
1229758005368	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229758005369	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229758005370	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229758005371	Synaptic Site I dimer interface [polypeptide binding]; other site
1229758005372	DNA binding site [nucleotide binding]
1229758005373	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1229758005374	Fic/DOC family; Region: Fic; cl00960
1229758005375	SIR2-like domain; Region: SIR2_2; pfam13289
1229758005376	Domain of unknown function DUF87; Region: DUF87; pfam01935
1229758005377	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1229758005378	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
1229758005379	active site
1229758005380	NTP binding site [chemical binding]; other site
1229758005381	metal binding triad [ion binding]; metal-binding site
1229758005382	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229758005383	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005384	P-loop; other site
1229758005385	Magnesium ion binding site [ion binding]; other site
1229758005386	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005387	Magnesium ion binding site [ion binding]; other site
1229758005388	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1229758005389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1229758005390	non-specific DNA binding site [nucleotide binding]; other site
1229758005391	salt bridge; other site
1229758005392	sequence-specific DNA binding site [nucleotide binding]; other site
1229758005393	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1229758005394	Replication initiation factor; Region: Rep_trans; pfam02486
1229758005395	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1229758005396	TcpE family; Region: TcpE; pfam12648
1229758005397	Antirestriction protein (ArdA); Region: ArdA; cl01953
1229758005398	AAA-like domain; Region: AAA_10; pfam12846
1229758005399	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1229758005400	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758005401	catalytic residues [active]
1229758005402	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1229758005403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1229758005404	HTH-like domain; Region: HTH_21; pfam13276
1229758005405	Integrase core domain; Region: rve; pfam00665
1229758005406	Integrase core domain; Region: rve_2; pfam13333
1229758005407	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1229758005408	Transposase; Region: HTH_Tnp_1; pfam01527
1229758005409	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1229758005410	active site
1229758005411	catalytic site [active]
1229758005412	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1229758005413	active site
1229758005414	catalytic site [active]
1229758005415	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1229758005416	Cna protein B-type domain; Region: Cna_B; pfam05738
1229758005417	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1229758005418	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1229758005419	metal ion-dependent adhesion site (MIDAS); other site
1229758005420	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1229758005421	domain interaction interfaces [polypeptide binding]; other site
1229758005422	Cna protein B-type domain; Region: Cna_B; pfam05738
1229758005423	Cna protein B-type domain; Region: Cna_B; pfam05738
1229758005424	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1229758005425	HTH-like domain; Region: HTH_21; pfam13276
1229758005426	Integrase core domain; Region: rve; pfam00665
1229758005427	Integrase core domain; Region: rve_2; pfam13333
1229758005428	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229758005429	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005430	P-loop; other site
1229758005431	Magnesium ion binding site [ion binding]; other site
1229758005432	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005433	Magnesium ion binding site [ion binding]; other site
1229758005434	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1229758005435	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1229758005436	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1229758005437	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1229758005438	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1229758005439	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1229758005440	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1229758005441	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1229758005442	Cl- selectivity filter; other site
1229758005443	Cl- binding residues [ion binding]; other site
1229758005444	pore gating glutamate residue; other site
1229758005445	dimer interface [polypeptide binding]; other site
1229758005446	H+/Cl- coupling transport residue; other site
1229758005447	TrkA-C domain; Region: TrkA_C; pfam02080
1229758005448	CrcB-like protein; Region: CRCB; cl09114
1229758005449	CrcB-like protein; Region: CRCB; pfam02537
1229758005450	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1229758005451	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229758005452	catalytic residues [active]
1229758005453	catalytic nucleophile [active]
1229758005454	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229758005455	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229758005456	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229758005457	Synaptic Site I dimer interface [polypeptide binding]; other site
1229758005458	DNA binding site [nucleotide binding]
1229758005459	Transposase; Region: HTH_Tnp_1; cl17663
1229758005460	HTH-like domain; Region: HTH_21; pfam13276
1229758005461	Integrase core domain; Region: rve; pfam00665
1229758005462	Integrase core domain; Region: rve_3; cl15866
1229758005463	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1229758005464	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1229758005465	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1229758005466	putative uracil binding site [chemical binding]; other site
1229758005467	putative active site [active]
1229758005468	Transposase; Region: HTH_Tnp_1; pfam01527
1229758005469	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1229758005470	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1229758005471	active site
1229758005472	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1229758005473	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1229758005474	Walker A/P-loop; other site
1229758005475	ATP binding site [chemical binding]; other site
1229758005476	Q-loop/lid; other site
1229758005477	ABC transporter signature motif; other site
1229758005478	Walker B; other site
1229758005479	D-loop; other site
1229758005480	H-loop/switch region; other site
1229758005481	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1229758005482	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229758005483	active site
1229758005484	DNA binding site [nucleotide binding]
1229758005485	Int/Topo IB signature motif; other site
1229758005486	CCC1-related family of proteins; Region: CCC1_like; cd01059
1229758005487	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1229758005488	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1229758005489	ligand binding site [chemical binding]; other site
1229758005490	flexible hinge region; other site
1229758005491	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1229758005492	putative switch regulator; other site
1229758005493	non-specific DNA interactions [nucleotide binding]; other site
1229758005494	DNA binding site [nucleotide binding]
1229758005495	sequence specific DNA binding site [nucleotide binding]; other site
1229758005496	putative cAMP binding site [chemical binding]; other site
1229758005497	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1229758005498	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1229758005499	dimerization interface [polypeptide binding]; other site
1229758005500	DPS ferroxidase diiron center [ion binding]; other site
1229758005501	ion pore; other site
1229758005502	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1229758005503	metal-binding site [ion binding]
1229758005504	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1229758005505	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758005506	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1229758005507	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1229758005508	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1229758005509	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1229758005510	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1229758005511	Helix-turn-helix domain; Region: HTH_38; pfam13936
1229758005512	Integrase core domain; Region: rve; pfam00665
1229758005513	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1229758005514	TrkA-N domain; Region: TrkA_N; pfam02254
1229758005515	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1229758005516	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1229758005517	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1229758005518	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
1229758005519	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
1229758005520	AAA-like domain; Region: AAA_10; pfam12846
1229758005521	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1229758005522	MobA/MobL family; Region: MobA_MobL; pfam03389
1229758005523	MobA/MobL family; Region: MobA_MobL; pfam03389
1229758005524	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
1229758005525	Zeta toxin; Region: Zeta_toxin; pfam06414
1229758005526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1229758005527	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1229758005528	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1229758005529	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005530	P-loop; other site
1229758005531	Magnesium ion binding site [ion binding]; other site
1229758005532	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1229758005533	Magnesium ion binding site [ion binding]; other site
1229758005534	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1229758005535	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1229758005536	catalytic residues [active]
1229758005537	catalytic nucleophile [active]
1229758005538	Presynaptic Site I dimer interface [polypeptide binding]; other site
1229758005539	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1229758005540	Synaptic Flat tetramer interface [polypeptide binding]; other site
1229758005541	Synaptic Site I dimer interface [polypeptide binding]; other site
1229758005542	DNA binding site [nucleotide binding]
1229758005543	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1229758005544	DNA-binding interface [nucleotide binding]; DNA binding site
1229758005545	Integrase core domain; Region: rve; pfam00665
1229758005546	Integrase core domain; Region: rve_3; cl15866
1229758005547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1229758005548	putative substrate translocation pore; other site
1229758005549	H+ Antiporter protein; Region: 2A0121; TIGR00900
1229758005550	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
1229758005551	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1229758005552	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1229758005553	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1229758005554	motif II; other site
1229758005555	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1229758005556	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1229758005557	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1229758005558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
1229758005559	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1229758005560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1229758005561	ATP binding site [chemical binding]; other site
1229758005562	putative Mg++ binding site [ion binding]; other site
1229758005563	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1229758005564	Alphavirus E1 glycoprotein; Region: Alpha_E1_glycop; pfam01589
1229758005565	Domain of unknown function (DUF955); Region: DUF955; cl01076
1229758005566	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1229758005567	DNA topoisomerase III; Provisional; Region: PRK07726
1229758005568	active site
1229758005569	putative interdomain interaction site [polypeptide binding]; other site
1229758005570	putative metal-binding site [ion binding]; other site
1229758005571	putative nucleotide binding site [chemical binding]; other site
1229758005572	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1229758005573	domain I; other site
1229758005574	DNA binding groove [nucleotide binding]
1229758005575	phosphate binding site [ion binding]; other site
1229758005576	domain II; other site
1229758005577	domain III; other site
1229758005578	nucleotide binding site [chemical binding]; other site
1229758005579	catalytic site [active]
1229758005580	domain IV; other site
1229758005581	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1229758005582	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1229758005583	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1229758005584	Walker A motif; other site
1229758005585	ATP binding site [chemical binding]; other site
1229758005586	Walker B motif; other site
1229758005587	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1229758005588	catalytic residues [active]
1229758005589	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1229758005590	catalytic residue [active]
1229758005591	NlpC/P60 family; Region: NLPC_P60; cl17555