-- dump date 20140619_131751 -- class Genbank::misc_feature -- table misc_feature_note -- id note 762550000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 762550000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 762550000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550000004 Walker A motif; other site 762550000005 ATP binding site [chemical binding]; other site 762550000006 Walker B motif; other site 762550000007 arginine finger; other site 762550000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 762550000009 DnaA box-binding interface [nucleotide binding]; other site 762550000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 762550000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 762550000012 putative DNA binding surface [nucleotide binding]; other site 762550000013 dimer interface [polypeptide binding]; other site 762550000014 beta-clamp/clamp loader binding surface; other site 762550000015 beta-clamp/translesion DNA polymerase binding surface; other site 762550000016 S4 domain; Region: S4_2; pfam13275 762550000017 recombination protein F; Reviewed; Region: recF; PRK00064 762550000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 762550000019 Walker A/P-loop; other site 762550000020 ATP binding site [chemical binding]; other site 762550000021 Q-loop/lid; other site 762550000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550000023 ABC transporter signature motif; other site 762550000024 Walker B; other site 762550000025 D-loop; other site 762550000026 H-loop/switch region; other site 762550000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762550000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550000029 Mg2+ binding site [ion binding]; other site 762550000030 G-X-G motif; other site 762550000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762550000032 anchoring element; other site 762550000033 dimer interface [polypeptide binding]; other site 762550000034 ATP binding site [chemical binding]; other site 762550000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762550000036 active site 762550000037 putative metal-binding site [ion binding]; other site 762550000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762550000039 DNA gyrase subunit A; Validated; Region: PRK05560 762550000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762550000041 CAP-like domain; other site 762550000042 active site 762550000043 primary dimer interface [polypeptide binding]; other site 762550000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550000050 PspC domain; Region: PspC; pfam04024 762550000051 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762550000052 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762550000053 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550000054 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762550000055 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 762550000056 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 762550000057 HlyD family secretion protein; Region: HlyD_3; pfam13437 762550000058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550000060 Walker A/P-loop; other site 762550000061 ATP binding site [chemical binding]; other site 762550000062 Q-loop/lid; other site 762550000063 ABC transporter signature motif; other site 762550000064 Walker B; other site 762550000065 D-loop; other site 762550000066 H-loop/switch region; other site 762550000067 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762550000068 FtsX-like permease family; Region: FtsX; pfam02687 762550000069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550000070 Coenzyme A binding pocket [chemical binding]; other site 762550000071 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762550000072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000073 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762550000074 Walker A/P-loop; other site 762550000075 ATP binding site [chemical binding]; other site 762550000076 Q-loop/lid; other site 762550000077 ABC transporter signature motif; other site 762550000078 Walker B; other site 762550000079 D-loop; other site 762550000080 H-loop/switch region; other site 762550000081 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 762550000082 active site 762550000083 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 762550000084 active site 762550000085 tetramer interface [polypeptide binding]; other site 762550000086 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 762550000087 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 762550000088 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 762550000089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000091 DNA binding site [nucleotide binding] 762550000092 domain linker motif; other site 762550000093 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550000094 dimerization interface [polypeptide binding]; other site 762550000095 ligand binding site [chemical binding]; other site 762550000096 D-ribose pyranase; Provisional; Region: PRK11797 762550000097 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 762550000098 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762550000099 Walker A/P-loop; other site 762550000100 ATP binding site [chemical binding]; other site 762550000101 Q-loop/lid; other site 762550000102 ABC transporter signature motif; other site 762550000103 Walker B; other site 762550000104 D-loop; other site 762550000105 H-loop/switch region; other site 762550000106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762550000107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762550000108 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 762550000109 TM-ABC transporter signature motif; other site 762550000110 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 762550000111 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 762550000112 ligand binding site [chemical binding]; other site 762550000113 dimerization interface [polypeptide binding]; other site 762550000114 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762550000115 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 762550000116 substrate binding site [chemical binding]; other site 762550000117 dimer interface [polypeptide binding]; other site 762550000118 ATP binding site [chemical binding]; other site 762550000119 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550000120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000121 active site 762550000122 dimer interface [polypeptide binding]; other site 762550000123 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762550000124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 762550000125 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 762550000126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762550000127 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550000128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762550000129 active site turn [active] 762550000130 phosphorylation site [posttranslational modification] 762550000131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762550000132 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762550000133 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550000134 substrate binding [chemical binding]; other site 762550000135 active site 762550000136 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762550000137 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762550000138 HPr interaction site; other site 762550000139 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550000140 active site 762550000141 phosphorylation site [posttranslational modification] 762550000142 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550000143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000144 non-specific DNA binding site [nucleotide binding]; other site 762550000145 salt bridge; other site 762550000146 sequence-specific DNA binding site [nucleotide binding]; other site 762550000147 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 762550000148 Putative cyclase; Region: Cyclase; pfam04199 762550000149 CAAX protease self-immunity; Region: Abi; pfam02517 762550000150 CAAX protease self-immunity; Region: Abi; pfam02517 762550000151 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550000152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000153 dimer interface [polypeptide binding]; other site 762550000154 conserved gate region; other site 762550000155 putative PBP binding loops; other site 762550000156 ABC-ATPase subunit interface; other site 762550000157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550000158 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550000159 substrate binding pocket [chemical binding]; other site 762550000160 membrane-bound complex binding site; other site 762550000161 hinge residues; other site 762550000162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000164 dimer interface [polypeptide binding]; other site 762550000165 conserved gate region; other site 762550000166 putative PBP binding loops; other site 762550000167 ABC-ATPase subunit interface; other site 762550000168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000169 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762550000170 Walker A/P-loop; other site 762550000171 ATP binding site [chemical binding]; other site 762550000172 Q-loop/lid; other site 762550000173 ABC transporter signature motif; other site 762550000174 Walker B; other site 762550000175 D-loop; other site 762550000176 H-loop/switch region; other site 762550000177 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 762550000178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550000179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000180 homodimer interface [polypeptide binding]; other site 762550000181 catalytic residue [active] 762550000182 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762550000183 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 762550000184 homodimer interface [polypeptide binding]; other site 762550000185 ligand binding site [chemical binding]; other site 762550000186 NAD binding site [chemical binding]; other site 762550000187 catalytic site [active] 762550000188 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000189 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762550000190 Walker A/P-loop; other site 762550000191 ATP binding site [chemical binding]; other site 762550000192 Q-loop/lid; other site 762550000193 ABC transporter signature motif; other site 762550000194 Walker B; other site 762550000195 D-loop; other site 762550000196 H-loop/switch region; other site 762550000197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000199 putative substrate translocation pore; other site 762550000200 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762550000201 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 762550000202 putative active site [active] 762550000203 putative FMN binding site [chemical binding]; other site 762550000204 putative substrate binding site [chemical binding]; other site 762550000205 putative catalytic residue [active] 762550000206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000208 putative substrate translocation pore; other site 762550000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000210 AAA domain; Region: AAA_28; pfam13521 762550000211 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 762550000212 Predicted transcriptional regulators [Transcription]; Region: COG1733 762550000213 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762550000214 EamA-like transporter family; Region: EamA; pfam00892 762550000215 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 762550000216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762550000217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762550000218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 762550000219 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550000220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000221 non-specific DNA binding site [nucleotide binding]; other site 762550000222 salt bridge; other site 762550000223 sequence-specific DNA binding site [nucleotide binding]; other site 762550000224 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 762550000225 potential frameshift: common BLAST hit: gi|116618234|ref|YP_818605.1| IS30 family transposase 762550000226 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550000227 Integrase core domain; Region: rve; pfam00665 762550000228 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550000229 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762550000230 Citrate transporter; Region: CitMHS; pfam03600 762550000231 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762550000232 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 762550000233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550000234 NAD(P) binding site [chemical binding]; other site 762550000235 active site 762550000236 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550000237 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762550000238 putative ligand binding site [chemical binding]; other site 762550000239 putative NAD binding site [chemical binding]; other site 762550000240 catalytic site [active] 762550000241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000243 DNA binding site [nucleotide binding] 762550000244 domain linker motif; other site 762550000245 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 762550000246 putative dimerization interface [polypeptide binding]; other site 762550000247 putative ligand binding site [chemical binding]; other site 762550000248 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 762550000249 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 762550000250 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762550000251 DNA binding residues [nucleotide binding] 762550000252 putative dimer interface [polypeptide binding]; other site 762550000253 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550000255 Walker A/P-loop; other site 762550000256 ATP binding site [chemical binding]; other site 762550000257 Q-loop/lid; other site 762550000258 ABC transporter signature motif; other site 762550000259 Walker B; other site 762550000260 D-loop; other site 762550000261 H-loop/switch region; other site 762550000262 FtsX-like permease family; Region: FtsX; pfam02687 762550000263 FtsX-like permease family; Region: FtsX; pfam02687 762550000264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762550000265 MarR family; Region: MarR; pfam01047 762550000266 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550000267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762550000268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550000269 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550000270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550000271 putative DNA binding site [nucleotide binding]; other site 762550000272 putative Zn2+ binding site [ion binding]; other site 762550000273 MarR family; Region: MarR_2; cl17246 762550000274 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550000275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550000277 Walker A/P-loop; other site 762550000278 ATP binding site [chemical binding]; other site 762550000279 Q-loop/lid; other site 762550000280 ABC transporter signature motif; other site 762550000281 Walker B; other site 762550000282 D-loop; other site 762550000283 H-loop/switch region; other site 762550000284 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550000285 Domain of unknown function DUF87; Region: DUF87; pfam01935 762550000286 AAA-like domain; Region: AAA_10; pfam12846 762550000287 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550000288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550000289 DNA binding site [nucleotide binding] 762550000290 domain linker motif; other site 762550000291 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550000292 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 762550000293 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550000294 substrate binding [chemical binding]; other site 762550000295 active site 762550000296 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 762550000297 galactoside permease; Reviewed; Region: lacY; PRK09528 762550000298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000299 putative substrate translocation pore; other site 762550000300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550000301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000302 salt bridge; other site 762550000303 non-specific DNA binding site [nucleotide binding]; other site 762550000304 sequence-specific DNA binding site [nucleotide binding]; other site 762550000305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550000306 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762550000307 Walker A/P-loop; other site 762550000308 ATP binding site [chemical binding]; other site 762550000309 Q-loop/lid; other site 762550000310 ABC transporter signature motif; other site 762550000311 Walker B; other site 762550000312 D-loop; other site 762550000313 H-loop/switch region; other site 762550000314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550000315 Transposase; Region: HTH_Tnp_1; cl17663 762550000316 Homeodomain-like domain; Region: HTH_23; cl17451 762550000317 putative transposase OrfB; Reviewed; Region: PHA02517 762550000318 HTH-like domain; Region: HTH_21; pfam13276 762550000319 Integrase core domain; Region: rve; pfam00665 762550000320 Integrase core domain; Region: rve_2; pfam13333 762550000321 Protein of unknown function (DUF975); Region: DUF975; cl10504 762550000322 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 762550000323 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 762550000324 active site 762550000325 HIGH motif; other site 762550000326 dimer interface [polypeptide binding]; other site 762550000327 KMSKS motif; other site 762550000328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550000329 RNA binding surface [nucleotide binding]; other site 762550000330 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 762550000331 D-lactate dehydrogenase; Validated; Region: PRK08605 762550000332 homodimer interface [polypeptide binding]; other site 762550000333 ligand binding site [chemical binding]; other site 762550000334 NAD binding site [chemical binding]; other site 762550000335 catalytic site [active] 762550000336 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 762550000337 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762550000338 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 762550000339 putative transporter; Provisional; Region: PRK03699 762550000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000341 putative substrate translocation pore; other site 762550000342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762550000343 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 762550000344 active site 762550000345 metal binding site [ion binding]; metal-binding site 762550000346 Predicted transcriptional regulators [Transcription]; Region: COG1733 762550000347 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762550000348 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 762550000349 potential frameshift: common BLAST hit: gi|170016351|ref|YP_001727271.1| putative transfer protein 762550000350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762550000351 active site 762550000352 motif I; other site 762550000353 motif II; other site 762550000354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550000355 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 762550000356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762550000357 minor groove reading motif; other site 762550000358 helix-hairpin-helix signature motif; other site 762550000359 substrate binding pocket [chemical binding]; other site 762550000360 active site 762550000361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550000362 S-adenosylmethionine binding site [chemical binding]; other site 762550000363 potential frameshift: common BLAST hit: gi|170017565|ref|YP_001728484.1| transposase 762550000364 HTH-like domain; Region: HTH_21; pfam13276 762550000365 putative transposase OrfB; Reviewed; Region: PHA02517 762550000366 YcaO-like family; Region: YcaO; pfam02624 762550000367 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550000368 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550000369 ABC transporter; Region: ABC_tran_2; pfam12848 762550000370 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 762550000371 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550000372 potential frameshift: common BLAST hit: gi|81428617|ref|YP_395617.1| putative zinc-containing alcohol dehydrogenase (oxidoreductase) 762550000373 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762550000374 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762550000375 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762550000376 substrate binding site [chemical binding]; other site 762550000377 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762550000378 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 762550000379 Walker A/P-loop; other site 762550000380 ATP binding site [chemical binding]; other site 762550000381 Q-loop/lid; other site 762550000382 ABC transporter signature motif; other site 762550000383 Walker B; other site 762550000384 D-loop; other site 762550000385 H-loop/switch region; other site 762550000386 TOBE domain; Region: TOBE_2; pfam08402 762550000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000388 dimer interface [polypeptide binding]; other site 762550000389 conserved gate region; other site 762550000390 putative PBP binding loops; other site 762550000391 ABC-ATPase subunit interface; other site 762550000392 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762550000393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000394 dimer interface [polypeptide binding]; other site 762550000395 conserved gate region; other site 762550000396 putative PBP binding loops; other site 762550000397 ABC-ATPase subunit interface; other site 762550000398 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762550000399 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762550000400 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762550000401 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550000402 active site 762550000403 catalytic site [active] 762550000404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550000405 catalytic core [active] 762550000406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762550000407 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000409 putative NAD(P) binding site [chemical binding]; other site 762550000410 Surface antigen [General function prediction only]; Region: COG3942 762550000411 CHAP domain; Region: CHAP; cl17642 762550000412 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 762550000413 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 762550000414 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 762550000415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550000416 active site 762550000417 phosphorylation site [posttranslational modification] 762550000418 intermolecular recognition site; other site 762550000419 dimerization interface [polypeptide binding]; other site 762550000420 LytTr DNA-binding domain; Region: LytTR; smart00850 762550000421 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 762550000422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550000423 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550000424 active site 762550000425 motif I; other site 762550000426 motif II; other site 762550000427 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762550000428 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 762550000429 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 762550000430 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550000431 transcriptional antiterminator BglG; Provisional; Region: PRK09772 762550000432 CAT RNA binding domain; Region: CAT_RBD; smart01061 762550000433 PRD domain; Region: PRD; pfam00874 762550000434 PRD domain; Region: PRD; pfam00874 762550000435 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 762550000436 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762550000437 active site turn [active] 762550000438 phosphorylation site [posttranslational modification] 762550000439 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762550000440 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762550000441 HPr interaction site; other site 762550000442 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550000443 active site 762550000444 phosphorylation site [posttranslational modification] 762550000445 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 762550000446 beta-galactosidase; Region: BGL; TIGR03356 762550000447 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 762550000448 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 762550000449 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 762550000450 dimer interface [polypeptide binding]; other site 762550000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000452 catalytic residue [active] 762550000453 cystathionine beta-lyase; Provisional; Region: PRK07671 762550000454 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 762550000455 homodimer interface [polypeptide binding]; other site 762550000456 substrate-cofactor binding pocket; other site 762550000457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550000458 catalytic residue [active] 762550000459 serine O-acetyltransferase; Region: cysE; TIGR01172 762550000460 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 762550000461 trimer interface [polypeptide binding]; other site 762550000462 active site 762550000463 substrate binding site [chemical binding]; other site 762550000464 CoA binding site [chemical binding]; other site 762550000465 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 762550000466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550000467 DNA-binding site [nucleotide binding]; DNA binding site 762550000468 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762550000469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762550000470 Walker A/P-loop; other site 762550000471 ATP binding site [chemical binding]; other site 762550000472 Q-loop/lid; other site 762550000473 ABC transporter signature motif; other site 762550000474 Walker B; other site 762550000475 D-loop; other site 762550000476 H-loop/switch region; other site 762550000477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762550000478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550000479 Walker A/P-loop; other site 762550000480 ATP binding site [chemical binding]; other site 762550000481 Q-loop/lid; other site 762550000482 ABC transporter signature motif; other site 762550000483 Walker B; other site 762550000484 D-loop; other site 762550000485 H-loop/switch region; other site 762550000486 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 762550000487 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 762550000488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762550000489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550000490 active site 762550000491 catalytic tetrad [active] 762550000492 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 762550000493 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762550000494 metal binding site [ion binding]; metal-binding site 762550000495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550000496 putative DNA binding site [nucleotide binding]; other site 762550000497 putative Zn2+ binding site [ion binding]; other site 762550000498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550000499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550000500 Walker A/P-loop; other site 762550000501 ATP binding site [chemical binding]; other site 762550000502 Q-loop/lid; other site 762550000503 ABC transporter signature motif; other site 762550000504 Walker B; other site 762550000505 D-loop; other site 762550000506 H-loop/switch region; other site 762550000507 potential frameshift: common BLAST hit: gi|296110890|ref|YP_003621271.1| ABC transporter permease and substrate binding protein 762550000508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550000509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550000510 active site 762550000511 phosphorylation site [posttranslational modification] 762550000512 intermolecular recognition site; other site 762550000513 dimerization interface [polypeptide binding]; other site 762550000514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550000515 DNA binding site [nucleotide binding] 762550000516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550000517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550000518 ATP binding site [chemical binding]; other site 762550000519 Mg2+ binding site [ion binding]; other site 762550000520 G-X-G motif; other site 762550000521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 762550000522 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 762550000523 Walker A/P-loop; other site 762550000524 ATP binding site [chemical binding]; other site 762550000525 Q-loop/lid; other site 762550000526 ABC transporter signature motif; other site 762550000527 Walker B; other site 762550000528 D-loop; other site 762550000529 H-loop/switch region; other site 762550000530 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 762550000531 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762550000532 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 762550000533 putative active site [active] 762550000534 catalytic site [active] 762550000535 putative metal binding site [ion binding]; other site 762550000536 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762550000537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762550000538 Walker A/P-loop; other site 762550000539 ATP binding site [chemical binding]; other site 762550000540 Q-loop/lid; other site 762550000541 ABC transporter signature motif; other site 762550000542 Walker B; other site 762550000543 D-loop; other site 762550000544 H-loop/switch region; other site 762550000545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000546 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 762550000547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762550000548 Walker A/P-loop; other site 762550000549 ATP binding site [chemical binding]; other site 762550000550 Q-loop/lid; other site 762550000551 ABC transporter signature motif; other site 762550000552 Walker B; other site 762550000553 D-loop; other site 762550000554 H-loop/switch region; other site 762550000555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762550000556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762550000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000558 dimer interface [polypeptide binding]; other site 762550000559 conserved gate region; other site 762550000560 putative PBP binding loops; other site 762550000561 ABC-ATPase subunit interface; other site 762550000562 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762550000563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000564 dimer interface [polypeptide binding]; other site 762550000565 conserved gate region; other site 762550000566 putative PBP binding loops; other site 762550000567 ABC-ATPase subunit interface; other site 762550000568 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 762550000569 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 762550000570 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 762550000571 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 762550000572 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 762550000573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550000574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000575 putative substrate translocation pore; other site 762550000576 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 762550000577 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 762550000578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550000579 ATP binding site [chemical binding]; other site 762550000580 putative Mg++ binding site [ion binding]; other site 762550000581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550000582 nucleotide binding region [chemical binding]; other site 762550000583 ATP-binding site [chemical binding]; other site 762550000584 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 762550000585 HRDC domain; Region: HRDC; pfam00570 762550000586 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 762550000587 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 762550000588 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 762550000589 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 762550000590 inhibitor binding site; inhibition site 762550000591 active site 762550000592 WIF domain; Region: WIF; cl02623 762550000593 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 762550000594 catalytic residues [active] 762550000595 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762550000596 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762550000597 nucleotide binding site [chemical binding]; other site 762550000598 xylose isomerase; Provisional; Region: PRK05474 762550000599 xylose isomerase; Region: xylose_isom_A; TIGR02630 762550000600 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 762550000601 N- and C-terminal domain interface [polypeptide binding]; other site 762550000602 D-xylulose kinase; Region: XylB; TIGR01312 762550000603 active site 762550000604 MgATP binding site [chemical binding]; other site 762550000605 catalytic site [active] 762550000606 metal binding site [ion binding]; metal-binding site 762550000607 xylulose binding site [chemical binding]; other site 762550000608 homodimer interface [polypeptide binding]; other site 762550000609 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 762550000610 Low molecular weight phosphatase family; Region: LMWPc; cd00115 762550000611 active site 762550000612 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 762550000613 transmembrane helices; other site 762550000614 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 762550000615 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 762550000616 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 762550000617 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 762550000618 Mga helix-turn-helix domain; Region: Mga; pfam05043 762550000619 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 762550000620 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550000621 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762550000622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550000623 NlpC/P60 family; Region: NLPC_P60; pfam00877 762550000624 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 762550000625 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 762550000626 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 762550000627 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550000628 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 762550000629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762550000630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762550000631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550000632 dimerization interface [polypeptide binding]; other site 762550000633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000634 benzoate transport; Region: 2A0115; TIGR00895 762550000635 putative substrate translocation pore; other site 762550000636 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 762550000637 nudix motif; other site 762550000638 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 762550000639 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550000640 Protein of unknown function (DUF805); Region: DUF805; pfam05656 762550000641 acetoin reductase; Validated; Region: PRK08643 762550000642 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 762550000643 NAD binding site [chemical binding]; other site 762550000644 homotetramer interface [polypeptide binding]; other site 762550000645 homodimer interface [polypeptide binding]; other site 762550000646 active site 762550000647 substrate binding site [chemical binding]; other site 762550000648 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 762550000649 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 762550000650 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 762550000651 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 762550000652 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762550000653 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 762550000654 NAD(P) binding pocket [chemical binding]; other site 762550000655 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 762550000656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550000657 active site 762550000658 nucleotide binding site [chemical binding]; other site 762550000659 HIGH motif; other site 762550000660 KMSKS motif; other site 762550000661 citrate lyase subunit gamma; Provisional; Region: PRK13253 762550000662 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 762550000663 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 762550000664 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 762550000665 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 762550000666 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762550000667 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 762550000668 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 762550000669 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 762550000670 putative catalytic cysteine [active] 762550000671 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 762550000672 putative active site [active] 762550000673 metal binding site [ion binding]; metal-binding site 762550000674 Predicted membrane protein [Function unknown]; Region: COG1511 762550000675 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550000676 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550000677 Predicted transcriptional regulator [Transcription]; Region: COG1959 762550000678 Transcriptional regulator; Region: Rrf2; pfam02082 762550000679 Transcriptional regulator; Region: Rrf2; cl17282 762550000680 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762550000681 MarR family; Region: MarR; pfam01047 762550000682 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550000683 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 762550000684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550000685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550000686 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000687 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000688 putative NAD(P) binding site [chemical binding]; other site 762550000689 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 762550000690 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550000691 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 762550000692 active site 762550000693 SH3-like domain; Region: SH3_8; pfam13457 762550000694 SH3-like domain; Region: SH3_8; pfam13457 762550000695 SH3-like domain; Region: SH3_8; pfam13457 762550000696 SH3-like domain; Region: SH3_8; pfam13457 762550000697 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 762550000698 putative ion selectivity filter; other site 762550000699 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762550000700 putative pore gating glutamate residue; other site 762550000701 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550000702 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000703 non-specific DNA binding site [nucleotide binding]; other site 762550000704 salt bridge; other site 762550000705 sequence-specific DNA binding site [nucleotide binding]; other site 762550000706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762550000707 active site 762550000708 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762550000709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550000710 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550000711 ABC transporter; Region: ABC_tran_2; pfam12848 762550000712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550000713 Biotin operon repressor [Transcription]; Region: BirA; COG1654 762550000714 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 762550000715 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 762550000716 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 762550000717 BioY family; Region: BioY; pfam02632 762550000718 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 762550000719 topology modulation protein; Reviewed; Region: PRK08118 762550000720 AAA domain; Region: AAA_17; pfam13207 762550000721 alanine racemase; Reviewed; Region: alr; PRK00053 762550000722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762550000723 active site 762550000724 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550000725 dimer interface [polypeptide binding]; other site 762550000726 substrate binding site [chemical binding]; other site 762550000727 catalytic residues [active] 762550000728 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 762550000729 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762550000730 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 762550000731 putative active site [active] 762550000732 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550000733 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 762550000734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550000735 Walker A/P-loop; other site 762550000736 ATP binding site [chemical binding]; other site 762550000737 Q-loop/lid; other site 762550000738 ABC transporter signature motif; other site 762550000739 Walker B; other site 762550000740 D-loop; other site 762550000741 H-loop/switch region; other site 762550000742 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 762550000743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550000744 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 762550000745 Walker A/P-loop; other site 762550000746 ATP binding site [chemical binding]; other site 762550000747 Q-loop/lid; other site 762550000748 ABC transporter signature motif; other site 762550000749 Walker B; other site 762550000750 D-loop; other site 762550000751 H-loop/switch region; other site 762550000752 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550000753 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762550000754 Walker A/P-loop; other site 762550000755 ATP binding site [chemical binding]; other site 762550000756 Q-loop/lid; other site 762550000757 ABC transporter signature motif; other site 762550000758 Walker B; other site 762550000759 D-loop; other site 762550000760 H-loop/switch region; other site 762550000761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550000762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550000763 substrate binding pocket [chemical binding]; other site 762550000764 membrane-bound complex binding site; other site 762550000765 hinge residues; other site 762550000766 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000768 dimer interface [polypeptide binding]; other site 762550000769 conserved gate region; other site 762550000770 putative PBP binding loops; other site 762550000771 ABC-ATPase subunit interface; other site 762550000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000773 dimer interface [polypeptide binding]; other site 762550000774 putative PBP binding loops; other site 762550000775 ABC-ATPase subunit interface; other site 762550000776 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550000777 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550000778 peptide binding site [polypeptide binding]; other site 762550000779 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550000780 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550000781 peptide binding site [polypeptide binding]; other site 762550000782 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 762550000783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000784 dimer interface [polypeptide binding]; other site 762550000785 conserved gate region; other site 762550000786 putative PBP binding loops; other site 762550000787 ABC-ATPase subunit interface; other site 762550000788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 762550000789 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 762550000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550000791 dimer interface [polypeptide binding]; other site 762550000792 conserved gate region; other site 762550000793 putative PBP binding loops; other site 762550000794 ABC-ATPase subunit interface; other site 762550000795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 762550000796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762550000797 Walker A/P-loop; other site 762550000798 ATP binding site [chemical binding]; other site 762550000799 Q-loop/lid; other site 762550000800 ABC transporter signature motif; other site 762550000801 Walker B; other site 762550000802 D-loop; other site 762550000803 H-loop/switch region; other site 762550000804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 762550000805 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 762550000806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 762550000807 Walker A/P-loop; other site 762550000808 ATP binding site [chemical binding]; other site 762550000809 Q-loop/lid; other site 762550000810 ABC transporter signature motif; other site 762550000811 Walker B; other site 762550000812 D-loop; other site 762550000813 H-loop/switch region; other site 762550000814 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 762550000815 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 762550000816 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 762550000817 active site 762550000818 Zn binding site [ion binding]; other site 762550000819 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762550000820 Protein of unknown function (DUF419); Region: DUF419; pfam04237 762550000821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550000822 non-specific DNA binding site [nucleotide binding]; other site 762550000823 salt bridge; other site 762550000824 sequence-specific DNA binding site [nucleotide binding]; other site 762550000825 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 762550000826 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 762550000827 Walker A/P-loop; other site 762550000828 ATP binding site [chemical binding]; other site 762550000829 Q-loop/lid; other site 762550000830 ABC transporter signature motif; other site 762550000831 Walker B; other site 762550000832 D-loop; other site 762550000833 H-loop/switch region; other site 762550000834 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 762550000835 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 762550000836 FeS assembly protein SufD; Region: sufD; TIGR01981 762550000837 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 762550000838 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 762550000839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550000840 catalytic residue [active] 762550000841 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 762550000842 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 762550000843 trimerization site [polypeptide binding]; other site 762550000844 active site 762550000845 FeS assembly protein SufB; Region: sufB; TIGR01980 762550000846 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 762550000847 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 762550000848 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 762550000849 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 762550000850 active site 762550000851 catalytic residues [active] 762550000852 metal binding site [ion binding]; metal-binding site 762550000853 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 762550000854 tartrate dehydrogenase; Region: TTC; TIGR02089 762550000855 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 762550000856 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 762550000857 substrate binding site [chemical binding]; other site 762550000858 ligand binding site [chemical binding]; other site 762550000859 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 762550000860 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 762550000861 hypothetical protein; Provisional; Region: PRK14812 762550000862 substrate binding site [chemical binding]; other site 762550000863 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 762550000864 High-affinity nickel-transport protein; Region: NicO; cl00964 762550000865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550000866 DNA-binding site [nucleotide binding]; DNA binding site 762550000867 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 762550000868 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 762550000869 putative dimerization interface [polypeptide binding]; other site 762550000870 putative ligand binding site [chemical binding]; other site 762550000871 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 762550000872 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 762550000873 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 762550000874 intersubunit interface [polypeptide binding]; other site 762550000875 active site 762550000876 zinc binding site [ion binding]; other site 762550000877 Na+ binding site [ion binding]; other site 762550000878 L-arabinose isomerase; Provisional; Region: PRK02929 762550000879 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 762550000880 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762550000881 trimer interface [polypeptide binding]; other site 762550000882 substrate binding site [chemical binding]; other site 762550000883 Mn binding site [ion binding]; other site 762550000884 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 762550000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000886 putative substrate translocation pore; other site 762550000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550000888 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 762550000889 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 762550000890 putative N- and C-terminal domain interface [polypeptide binding]; other site 762550000891 putative active site [active] 762550000892 MgATP binding site [chemical binding]; other site 762550000893 catalytic site [active] 762550000894 metal binding site [ion binding]; metal-binding site 762550000895 putative carbohydrate binding site [chemical binding]; other site 762550000896 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 762550000897 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762550000898 intersubunit interface [polypeptide binding]; other site 762550000899 active site 762550000900 Zn2+ binding site [ion binding]; other site 762550000901 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 762550000902 Aspartase; Region: Aspartase; cd01357 762550000903 active sites [active] 762550000904 tetramer interface [polypeptide binding]; other site 762550000905 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550000906 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000907 active site 762550000908 dimer interface [polypeptide binding]; other site 762550000909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550000910 Coenzyme A binding pocket [chemical binding]; other site 762550000911 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762550000912 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 762550000913 ABC-ATPase subunit interface; other site 762550000914 dimer interface [polypeptide binding]; other site 762550000915 putative PBP binding regions; other site 762550000916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550000917 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 762550000918 Walker A/P-loop; other site 762550000919 ATP binding site [chemical binding]; other site 762550000920 Q-loop/lid; other site 762550000921 ABC transporter signature motif; other site 762550000922 Walker B; other site 762550000923 D-loop; other site 762550000924 H-loop/switch region; other site 762550000925 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 762550000926 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762550000927 metal binding site [ion binding]; metal-binding site 762550000928 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 762550000929 trimer interface [polypeptide binding]; other site 762550000930 active site 762550000931 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 762550000932 DNA repair protein RadA; Provisional; Region: PRK11823 762550000933 Walker A motif/ATP binding site; other site 762550000934 ATP binding site [chemical binding]; other site 762550000935 Walker B motif; other site 762550000936 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 762550000937 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550000938 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 762550000939 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550000940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550000941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550000942 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 762550000943 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762550000944 active site 762550000945 HIGH motif; other site 762550000946 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 762550000947 active site 762550000948 KMSKS motif; other site 762550000949 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550000950 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 762550000951 putative NAD(P) binding site [chemical binding]; other site 762550000952 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 762550000953 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 762550000954 NAD binding site [chemical binding]; other site 762550000955 substrate binding site [chemical binding]; other site 762550000956 catalytic Zn binding site [ion binding]; other site 762550000957 tetramer interface [polypeptide binding]; other site 762550000958 structural Zn binding site [ion binding]; other site 762550000959 hypothetical protein; Provisional; Region: PRK13661 762550000960 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550000961 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550000962 Walker A/P-loop; other site 762550000963 ATP binding site [chemical binding]; other site 762550000964 Q-loop/lid; other site 762550000965 ABC transporter signature motif; other site 762550000966 Walker B; other site 762550000967 D-loop; other site 762550000968 H-loop/switch region; other site 762550000969 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 762550000970 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550000971 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550000972 Walker A/P-loop; other site 762550000973 ATP binding site [chemical binding]; other site 762550000974 Q-loop/lid; other site 762550000975 ABC transporter signature motif; other site 762550000976 Walker B; other site 762550000977 D-loop; other site 762550000978 H-loop/switch region; other site 762550000979 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 762550000980 dipeptidase PepV; Reviewed; Region: PRK07318 762550000981 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762550000982 active site 762550000983 metal binding site [ion binding]; metal-binding site 762550000984 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 762550000985 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 762550000986 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 762550000987 dimer interface [polypeptide binding]; other site 762550000988 ssDNA binding site [nucleotide binding]; other site 762550000989 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550000990 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 762550000991 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 762550000992 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 762550000993 DHH family; Region: DHH; pfam01368 762550000994 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 762550000995 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 762550000996 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 762550000997 replicative DNA helicase; Region: DnaB; TIGR00665 762550000998 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 762550000999 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 762550001000 Walker A motif; other site 762550001001 ATP binding site [chemical binding]; other site 762550001002 Walker B motif; other site 762550001003 DNA binding loops [nucleotide binding] 762550001004 hypothetical protein; Provisional; Region: PRK04860 762550001005 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 762550001006 putative deacylase active site [active] 762550001007 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550001008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001009 DNA-binding site [nucleotide binding]; DNA binding site 762550001010 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762550001011 putative phosphoketolase; Provisional; Region: PRK05261 762550001012 XFP N-terminal domain; Region: XFP_N; pfam09364 762550001013 XFP C-terminal domain; Region: XFP_C; pfam09363 762550001014 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762550001015 nudix motif; other site 762550001016 sugar phosphate phosphatase; Provisional; Region: PRK10513 762550001017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550001018 active site 762550001019 motif I; other site 762550001020 motif II; other site 762550001021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550001022 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 762550001023 dimer interface [polypeptide binding]; other site 762550001024 catalytic triad [active] 762550001025 peroxidatic and resolving cysteines [active] 762550001026 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762550001027 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762550001028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550001029 active site 762550001030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550001031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550001032 active site 762550001033 phosphorylation site [posttranslational modification] 762550001034 intermolecular recognition site; other site 762550001035 dimerization interface [polypeptide binding]; other site 762550001036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550001037 DNA binding site [nucleotide binding] 762550001038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 762550001039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 762550001040 dimerization interface [polypeptide binding]; other site 762550001041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 762550001042 putative active site [active] 762550001043 heme pocket [chemical binding]; other site 762550001044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762550001045 dimer interface [polypeptide binding]; other site 762550001046 phosphorylation site [posttranslational modification] 762550001047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001048 ATP binding site [chemical binding]; other site 762550001049 Mg2+ binding site [ion binding]; other site 762550001050 G-X-G motif; other site 762550001051 YycH protein; Region: YycH; pfam07435 762550001052 YycH protein; Region: YycI; cl02015 762550001053 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762550001054 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 762550001055 protein binding site [polypeptide binding]; other site 762550001056 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 762550001057 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550001058 dimer interface [polypeptide binding]; other site 762550001059 substrate binding site [chemical binding]; other site 762550001060 ATP binding site [chemical binding]; other site 762550001061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550001062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550001063 putative substrate translocation pore; other site 762550001064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550001065 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 762550001066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 762550001067 minor groove reading motif; other site 762550001068 helix-hairpin-helix signature motif; other site 762550001069 substrate binding pocket [chemical binding]; other site 762550001070 active site 762550001071 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 762550001072 DNA binding and oxoG recognition site [nucleotide binding] 762550001073 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762550001074 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762550001075 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550001076 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762550001077 hypothetical protein; Validated; Region: PRK07668 762550001078 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550001079 TRAM domain; Region: TRAM; pfam01938 762550001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550001081 S-adenosylmethionine binding site [chemical binding]; other site 762550001082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762550001083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550001084 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 762550001085 Walker A motif; other site 762550001086 ATP binding site [chemical binding]; other site 762550001087 Walker B motif; other site 762550001088 arginine finger; other site 762550001089 UvrB/uvrC motif; Region: UVR; pfam02151 762550001090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550001091 Walker A motif; other site 762550001092 ATP binding site [chemical binding]; other site 762550001093 Walker B motif; other site 762550001094 arginine finger; other site 762550001095 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550001096 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 762550001097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001098 DNA-binding site [nucleotide binding]; DNA binding site 762550001099 UTRA domain; Region: UTRA; pfam07702 762550001100 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762550001101 HPr interaction site; other site 762550001102 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550001103 active site 762550001104 phosphorylation site [posttranslational modification] 762550001105 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550001106 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762550001107 active site turn [active] 762550001108 phosphorylation site [posttranslational modification] 762550001109 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762550001110 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 762550001111 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 762550001112 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 762550001113 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 762550001114 beta-phosphoglucomutase; Region: bPGM; TIGR01990 762550001115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550001116 motif II; other site 762550001117 Membrane transport protein; Region: Mem_trans; cl09117 762550001118 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 762550001119 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 762550001120 putative homodimer interface [polypeptide binding]; other site 762550001121 putative ligand binding site [chemical binding]; other site 762550001122 putative NAD binding site [chemical binding]; other site 762550001123 catalytic site [active] 762550001124 sensory histidine kinase DcuS; Provisional; Region: PRK11086 762550001125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001126 ATP binding site [chemical binding]; other site 762550001127 Mg2+ binding site [ion binding]; other site 762550001128 G-X-G motif; other site 762550001129 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 762550001130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550001131 active site 762550001132 phosphorylation site [posttranslational modification] 762550001133 intermolecular recognition site; other site 762550001134 dimerization interface [polypeptide binding]; other site 762550001135 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 762550001136 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762550001137 nudix motif; other site 762550001138 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 762550001139 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762550001140 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762550001141 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762550001142 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 762550001143 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 762550001144 active site 762550001145 HIGH motif; other site 762550001146 dimer interface [polypeptide binding]; other site 762550001147 KMSKS motif; other site 762550001148 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550001149 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 762550001150 active site 762550001151 lysine transporter; Provisional; Region: PRK10836 762550001152 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 762550001153 rod shape-determining protein MreB; Provisional; Region: PRK13930 762550001154 MreB and similar proteins; Region: MreB_like; cd10225 762550001155 nucleotide binding site [chemical binding]; other site 762550001156 Mg binding site [ion binding]; other site 762550001157 putative protofilament interaction site [polypeptide binding]; other site 762550001158 RodZ interaction site [polypeptide binding]; other site 762550001159 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 762550001160 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 762550001161 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 762550001162 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 762550001163 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 762550001164 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 762550001165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001167 non-specific DNA binding site [nucleotide binding]; other site 762550001168 salt bridge; other site 762550001169 sequence-specific DNA binding site [nucleotide binding]; other site 762550001170 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550001171 Ligand Binding Site [chemical binding]; other site 762550001172 recombination factor protein RarA; Reviewed; Region: PRK13342 762550001173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550001174 Walker A motif; other site 762550001175 ATP binding site [chemical binding]; other site 762550001176 Walker B motif; other site 762550001177 arginine finger; other site 762550001178 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 762550001179 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 762550001180 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 762550001181 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 762550001182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550001183 RNA binding surface [nucleotide binding]; other site 762550001184 septation ring formation regulator EzrA; Provisional; Region: PRK04778 762550001185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762550001186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 762550001187 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 762550001188 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550001189 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762550001190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550001191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550001192 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 762550001193 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 762550001194 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 762550001195 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 762550001196 putative homodimer interface [polypeptide binding]; other site 762550001197 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 762550001198 heterodimer interface [polypeptide binding]; other site 762550001199 homodimer interface [polypeptide binding]; other site 762550001200 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 762550001201 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 762550001202 23S rRNA interface [nucleotide binding]; other site 762550001203 L7/L12 interface [polypeptide binding]; other site 762550001204 putative thiostrepton binding site; other site 762550001205 L25 interface [polypeptide binding]; other site 762550001206 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 762550001207 mRNA/rRNA interface [nucleotide binding]; other site 762550001208 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 762550001209 23S rRNA interface [nucleotide binding]; other site 762550001210 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 762550001211 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 762550001212 peripheral dimer interface [polypeptide binding]; other site 762550001213 core dimer interface [polypeptide binding]; other site 762550001214 L10 interface [polypeptide binding]; other site 762550001215 L11 interface [polypeptide binding]; other site 762550001216 putative EF-Tu interaction site [polypeptide binding]; other site 762550001217 putative EF-G interaction site [polypeptide binding]; other site 762550001218 Methyltransferase domain; Region: Methyltransf_31; pfam13847 762550001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550001220 S-adenosylmethionine binding site [chemical binding]; other site 762550001221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 762550001222 nucleoside/Zn binding site; other site 762550001223 dimer interface [polypeptide binding]; other site 762550001224 catalytic motif [active] 762550001225 HD domain; Region: HD; pfam01966 762550001226 Zn2+ binding site [ion binding]; other site 762550001227 Mg2+ binding site [ion binding]; other site 762550001228 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 762550001229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550001230 Walker A motif; other site 762550001231 ATP binding site [chemical binding]; other site 762550001232 Walker B motif; other site 762550001233 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 762550001234 recombination protein RecR; Reviewed; Region: recR; PRK00076 762550001235 RecR protein; Region: RecR; pfam02132 762550001236 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 762550001237 putative active site [active] 762550001238 putative metal-binding site [ion binding]; other site 762550001239 tetramer interface [polypeptide binding]; other site 762550001240 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 762550001241 thymidylate kinase; Validated; Region: tmk; PRK00698 762550001242 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 762550001243 TMP-binding site; other site 762550001244 ATP-binding site [chemical binding]; other site 762550001245 Protein of unknown function (DUF970); Region: DUF970; cl17525 762550001246 DNA polymerase III subunit delta'; Validated; Region: PRK08058 762550001247 DNA polymerase III subunit delta'; Validated; Region: PRK08485 762550001248 Predicted methyltransferases [General function prediction only]; Region: COG0313 762550001249 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 762550001250 putative SAM binding site [chemical binding]; other site 762550001251 putative homodimer interface [polypeptide binding]; other site 762550001252 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 762550001253 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 762550001254 active site 762550001255 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 762550001256 active site 2 [active] 762550001257 active site 1 [active] 762550001258 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 762550001259 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 762550001260 NAD binding site [chemical binding]; other site 762550001261 homodimer interface [polypeptide binding]; other site 762550001262 active site 762550001263 substrate binding site [chemical binding]; other site 762550001264 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 762550001265 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762550001266 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762550001267 Substrate-binding site [chemical binding]; other site 762550001268 Substrate specificity [chemical binding]; other site 762550001269 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 762550001270 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 762550001271 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 762550001272 active site 762550001273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762550001274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762550001275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762550001276 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762550001277 ATP binding site [chemical binding]; other site 762550001278 putative Mg++ binding site [ion binding]; other site 762550001279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001280 nucleotide binding region [chemical binding]; other site 762550001281 ATP-binding site [chemical binding]; other site 762550001282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550001283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550001284 active site 762550001285 phosphorylation site [posttranslational modification] 762550001286 intermolecular recognition site; other site 762550001287 dimerization interface [polypeptide binding]; other site 762550001288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550001289 DNA binding site [nucleotide binding] 762550001290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550001291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762550001292 dimer interface [polypeptide binding]; other site 762550001293 phosphorylation site [posttranslational modification] 762550001294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001295 ATP binding site [chemical binding]; other site 762550001296 Mg2+ binding site [ion binding]; other site 762550001297 G-X-G motif; other site 762550001298 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 762550001299 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550001300 catalytic residues [active] 762550001301 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 762550001302 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 762550001303 substrate binding site [chemical binding]; other site 762550001304 THF binding site; other site 762550001305 zinc-binding site [ion binding]; other site 762550001306 S-ribosylhomocysteinase; Provisional; Region: PRK02260 762550001307 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 762550001308 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 762550001309 peptide binding site [polypeptide binding]; other site 762550001310 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 762550001311 Peptidase C26; Region: Peptidase_C26; pfam07722 762550001312 catalytic triad [active] 762550001313 Amino acid permease; Region: AA_permease_2; pfam13520 762550001314 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 762550001315 catalytic triad [active] 762550001316 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 762550001317 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550001318 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 762550001319 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762550001320 NlpC/P60 family; Region: NLPC_P60; cl17555 762550001321 thymidine kinase; Provisional; Region: PRK04296 762550001322 peptide chain release factor 1; Validated; Region: prfA; PRK00591 762550001323 This domain is found in peptide chain release factors; Region: PCRF; smart00937 762550001324 RF-1 domain; Region: RF-1; pfam00472 762550001325 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 762550001326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550001327 S-adenosylmethionine binding site [chemical binding]; other site 762550001328 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 762550001329 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 762550001330 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 762550001331 dimerization domain swap beta strand [polypeptide binding]; other site 762550001332 regulatory protein interface [polypeptide binding]; other site 762550001333 active site 762550001334 regulatory phosphorylation site [posttranslational modification]; other site 762550001335 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 762550001336 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 762550001337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 762550001338 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 762550001339 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 762550001340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550001341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 762550001342 DNA binding residues [nucleotide binding] 762550001343 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 762550001344 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 762550001345 Glycoprotease family; Region: Peptidase_M22; pfam00814 762550001346 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762550001347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550001348 Coenzyme A binding pocket [chemical binding]; other site 762550001349 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 762550001350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550001351 Coenzyme A binding pocket [chemical binding]; other site 762550001352 UGMP family protein; Validated; Region: PRK09604 762550001353 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 762550001354 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 762550001355 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 762550001356 CoA binding domain; Region: CoA_binding; pfam02629 762550001357 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 762550001358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 762550001359 Predicted membrane protein [Function unknown]; Region: COG2246 762550001360 GtrA-like protein; Region: GtrA; pfam04138 762550001361 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550001362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550001363 active site 762550001364 motif I; other site 762550001365 motif II; other site 762550001366 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 762550001367 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 762550001368 dimer interface [polypeptide binding]; other site 762550001369 FMN binding site [chemical binding]; other site 762550001370 NADPH bind site [chemical binding]; other site 762550001371 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001373 non-specific DNA binding site [nucleotide binding]; other site 762550001374 salt bridge; other site 762550001375 sequence-specific DNA binding site [nucleotide binding]; other site 762550001376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001377 non-specific DNA binding site [nucleotide binding]; other site 762550001378 salt bridge; other site 762550001379 sequence-specific DNA binding site [nucleotide binding]; other site 762550001380 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550001381 MucBP domain; Region: MucBP; pfam06458 762550001382 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 762550001383 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 762550001384 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 762550001385 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 762550001386 active pocket/dimerization site; other site 762550001387 active site 762550001388 phosphorylation site [posttranslational modification] 762550001389 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 762550001390 active site 762550001391 phosphorylation site [posttranslational modification] 762550001392 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 762550001393 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 762550001394 Domain of unknown function (DUF956); Region: DUF956; cl01917 762550001395 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550001396 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550001397 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550001398 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762550001399 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 762550001400 oligomerisation interface [polypeptide binding]; other site 762550001401 mobile loop; other site 762550001402 roof hairpin; other site 762550001403 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 762550001404 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 762550001405 ring oligomerisation interface [polypeptide binding]; other site 762550001406 ATP/Mg binding site [chemical binding]; other site 762550001407 stacking interactions; other site 762550001408 hinge regions; other site 762550001409 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762550001410 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 762550001411 trimer interface [polypeptide binding]; other site 762550001412 active site 762550001413 G bulge; other site 762550001414 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 762550001415 UbiA prenyltransferase family; Region: UbiA; pfam01040 762550001416 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 762550001417 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 762550001418 putative active site [active] 762550001419 catalytic residue [active] 762550001420 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 762550001421 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 762550001422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550001423 ATP binding site [chemical binding]; other site 762550001424 putative Mg++ binding site [ion binding]; other site 762550001425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001426 nucleotide binding region [chemical binding]; other site 762550001427 ATP-binding site [chemical binding]; other site 762550001428 TRCF domain; Region: TRCF; pfam03461 762550001429 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550001430 RNA binding surface [nucleotide binding]; other site 762550001431 Septum formation initiator; Region: DivIC; pfam04977 762550001432 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 762550001433 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 762550001434 Ligand Binding Site [chemical binding]; other site 762550001435 TilS substrate C-terminal domain; Region: TilS_C; smart00977 762550001436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550001437 active site 762550001438 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 762550001439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550001440 Walker A motif; other site 762550001441 ATP binding site [chemical binding]; other site 762550001442 Walker B motif; other site 762550001443 arginine finger; other site 762550001444 Peptidase family M41; Region: Peptidase_M41; pfam01434 762550001445 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 762550001446 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 762550001447 dimerization interface [polypeptide binding]; other site 762550001448 domain crossover interface; other site 762550001449 redox-dependent activation switch; other site 762550001450 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 762550001451 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 762550001452 dimer interface [polypeptide binding]; other site 762550001453 putative anticodon binding site; other site 762550001454 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 762550001455 motif 1; other site 762550001456 active site 762550001457 motif 2; other site 762550001458 motif 3; other site 762550001459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550001460 putative substrate translocation pore; other site 762550001461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550001462 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 762550001463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 762550001464 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 762550001465 Predicted transcriptional regulators [Transcription]; Region: COG1733 762550001466 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762550001467 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550001468 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550001469 Walker A/P-loop; other site 762550001470 ATP binding site [chemical binding]; other site 762550001471 Q-loop/lid; other site 762550001472 ABC transporter signature motif; other site 762550001473 Walker B; other site 762550001474 D-loop; other site 762550001475 H-loop/switch region; other site 762550001476 FtsX-like permease family; Region: FtsX; pfam02687 762550001477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550001478 active site 762550001479 HIGH motif; other site 762550001480 nucleotide binding site [chemical binding]; other site 762550001481 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001483 sequence-specific DNA binding site [nucleotide binding]; other site 762550001484 salt bridge; other site 762550001485 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 762550001486 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762550001487 AAA domain; Region: AAA_12; pfam13087 762550001488 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 762550001489 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762550001490 Sulfate transporter family; Region: Sulfate_transp; pfam00916 762550001491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550001492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762550001493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550001494 ABC transporter signature motif; other site 762550001495 Walker B; other site 762550001496 D-loop; other site 762550001497 H-loop/switch region; other site 762550001498 LytTr DNA-binding domain; Region: LytTR; smart00850 762550001499 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 762550001500 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 762550001501 active site 762550001502 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550001503 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 762550001504 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 762550001505 active site 762550001506 putative interdomain interaction site [polypeptide binding]; other site 762550001507 putative metal-binding site [ion binding]; other site 762550001508 putative nucleotide binding site [chemical binding]; other site 762550001509 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 762550001510 domain I; other site 762550001511 DNA binding groove [nucleotide binding] 762550001512 phosphate binding site [ion binding]; other site 762550001513 domain II; other site 762550001514 domain III; other site 762550001515 nucleotide binding site [chemical binding]; other site 762550001516 catalytic site [active] 762550001517 domain IV; other site 762550001518 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762550001519 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762550001520 substrate binding site [chemical binding]; other site 762550001521 dimer interface [polypeptide binding]; other site 762550001522 catalytic triad [active] 762550001523 competence damage-inducible protein A; Provisional; Region: PRK00549 762550001524 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 762550001525 putative MPT binding site; other site 762550001526 Competence-damaged protein; Region: CinA; cl00666 762550001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550001528 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762550001529 NAD(P) binding site [chemical binding]; other site 762550001530 active site 762550001531 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 762550001532 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 762550001533 dimer interface [polypeptide binding]; other site 762550001534 active site 762550001535 metal binding site [ion binding]; metal-binding site 762550001536 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 762550001537 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001538 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550001539 Walker A/P-loop; other site 762550001540 ATP binding site [chemical binding]; other site 762550001541 Q-loop/lid; other site 762550001542 ABC transporter signature motif; other site 762550001543 Walker B; other site 762550001544 D-loop; other site 762550001545 H-loop/switch region; other site 762550001546 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001547 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550001548 Walker A/P-loop; other site 762550001549 ATP binding site [chemical binding]; other site 762550001550 Q-loop/lid; other site 762550001551 ABC transporter signature motif; other site 762550001552 Walker B; other site 762550001553 D-loop; other site 762550001554 H-loop/switch region; other site 762550001555 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 762550001556 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762550001557 RibD C-terminal domain; Region: RibD_C; cl17279 762550001558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 762550001559 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 762550001560 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762550001561 tetramer interfaces [polypeptide binding]; other site 762550001562 binuclear metal-binding site [ion binding]; other site 762550001563 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 762550001564 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 762550001565 active site 762550001566 dimer interface [polypeptide binding]; other site 762550001567 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550001568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001569 DNA-binding site [nucleotide binding]; DNA binding site 762550001570 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762550001571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550001572 dimer interface [polypeptide binding]; other site 762550001573 conserved gate region; other site 762550001574 ABC-ATPase subunit interface; other site 762550001575 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 762550001576 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 762550001577 Walker A/P-loop; other site 762550001578 ATP binding site [chemical binding]; other site 762550001579 Q-loop/lid; other site 762550001580 ABC transporter signature motif; other site 762550001581 Walker B; other site 762550001582 D-loop; other site 762550001583 H-loop/switch region; other site 762550001584 NIL domain; Region: NIL; pfam09383 762550001585 hypothetical protein; Provisional; Region: PRK06446 762550001586 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 762550001587 metal binding site [ion binding]; metal-binding site 762550001588 dimer interface [polypeptide binding]; other site 762550001589 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762550001590 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762550001591 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 762550001592 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 762550001593 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 762550001594 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 762550001595 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 762550001596 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762550001597 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550001598 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762550001599 Soluble P-type ATPase [General function prediction only]; Region: COG4087 762550001600 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762550001601 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762550001602 metal binding site 2 [ion binding]; metal-binding site 762550001603 putative DNA binding helix; other site 762550001604 metal binding site 1 [ion binding]; metal-binding site 762550001605 dimer interface [polypeptide binding]; other site 762550001606 structural Zn2+ binding site [ion binding]; other site 762550001607 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762550001608 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 762550001609 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 762550001610 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 762550001611 S-adenosylmethionine synthetase; Validated; Region: PRK05250 762550001612 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 762550001613 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 762550001614 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 762550001615 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 762550001616 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 762550001617 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762550001618 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 762550001619 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 762550001620 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762550001621 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762550001622 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762550001623 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 762550001624 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 762550001625 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550001626 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 762550001627 elongation factor P; Validated; Region: PRK00529 762550001628 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 762550001629 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 762550001630 RNA binding site [nucleotide binding]; other site 762550001631 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 762550001632 RNA binding site [nucleotide binding]; other site 762550001633 Asp23 family; Region: Asp23; pfam03780 762550001634 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 762550001635 putative RNA binding site [nucleotide binding]; other site 762550001636 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 762550001637 active site 762550001638 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 762550001639 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 762550001640 putative active site [active] 762550001641 putative metal binding site [ion binding]; other site 762550001642 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 762550001643 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 762550001644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550001645 S-adenosylmethionine binding site [chemical binding]; other site 762550001646 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 762550001647 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 762550001648 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 762550001649 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550001650 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 762550001651 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 762550001652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 762550001653 pur operon repressor; Provisional; Region: PRK09213 762550001654 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 762550001655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550001656 active site 762550001657 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 762550001658 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 762550001659 Substrate binding site; other site 762550001660 Mg++ binding site; other site 762550001661 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 762550001662 active site 762550001663 substrate binding site [chemical binding]; other site 762550001664 CoA binding site [chemical binding]; other site 762550001665 SLBB domain; Region: SLBB; pfam10531 762550001666 comEA protein; Region: comE; TIGR01259 762550001667 Helix-hairpin-helix motif; Region: HHH; pfam00633 762550001668 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 762550001669 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 762550001670 Competence protein; Region: Competence; pfam03772 762550001671 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 762550001672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762550001673 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 762550001674 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 762550001675 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 762550001676 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 762550001677 16S/18S rRNA binding site [nucleotide binding]; other site 762550001678 S13e-L30e interaction site [polypeptide binding]; other site 762550001679 25S rRNA binding site [nucleotide binding]; other site 762550001680 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 762550001681 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 762550001682 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 762550001683 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 762550001684 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 762550001685 GatB domain; Region: GatB_Yqey; smart00845 762550001686 putative lipid kinase; Reviewed; Region: PRK13055 762550001687 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 762550001688 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 762550001689 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550001690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550001691 S-adenosylmethionine binding site [chemical binding]; other site 762550001692 CTP synthetase; Validated; Region: pyrG; PRK05380 762550001693 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 762550001694 Catalytic site [active] 762550001695 active site 762550001696 UTP binding site [chemical binding]; other site 762550001697 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 762550001698 active site 762550001699 putative oxyanion hole; other site 762550001700 catalytic triad [active] 762550001701 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 762550001702 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 762550001703 GIY-YIG motif/motif A; other site 762550001704 active site 762550001705 catalytic site [active] 762550001706 putative DNA binding site [nucleotide binding]; other site 762550001707 metal binding site [ion binding]; metal-binding site 762550001708 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 762550001709 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 762550001710 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 762550001711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762550001712 Walker A/P-loop; other site 762550001713 ATP binding site [chemical binding]; other site 762550001714 Q-loop/lid; other site 762550001715 ABC transporter signature motif; other site 762550001716 Walker B; other site 762550001717 D-loop; other site 762550001718 H-loop/switch region; other site 762550001719 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 762550001720 GTPase CgtA; Reviewed; Region: obgE; PRK12297 762550001721 GTP1/OBG; Region: GTP1_OBG; pfam01018 762550001722 Obg GTPase; Region: Obg; cd01898 762550001723 G1 box; other site 762550001724 GTP/Mg2+ binding site [chemical binding]; other site 762550001725 Switch I region; other site 762550001726 G2 box; other site 762550001727 G3 box; other site 762550001728 Switch II region; other site 762550001729 G4 box; other site 762550001730 G5 box; other site 762550001731 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 762550001732 acetolactate synthase; Reviewed; Region: PRK08617 762550001733 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 762550001734 PYR/PP interface [polypeptide binding]; other site 762550001735 dimer interface [polypeptide binding]; other site 762550001736 TPP binding site [chemical binding]; other site 762550001737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762550001738 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 762550001739 TPP-binding site [chemical binding]; other site 762550001740 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 762550001741 Class III ribonucleotide reductase; Region: RNR_III; cd01675 762550001742 effector binding site; other site 762550001743 active site 762550001744 Zn binding site [ion binding]; other site 762550001745 glycine loop; other site 762550001746 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 762550001747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 762550001748 FeS/SAM binding site; other site 762550001749 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 762550001750 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 762550001751 Walker A/P-loop; other site 762550001752 ATP binding site [chemical binding]; other site 762550001753 Q-loop/lid; other site 762550001754 ABC transporter signature motif; other site 762550001755 Walker B; other site 762550001756 D-loop; other site 762550001757 H-loop/switch region; other site 762550001758 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 762550001759 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 762550001760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550001761 active site 762550001762 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 762550001763 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 762550001764 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 762550001765 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 762550001766 Ligand binding site; other site 762550001767 Putative Catalytic site; other site 762550001768 DXD motif; other site 762550001769 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762550001770 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762550001771 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762550001772 Probable Catalytic site; other site 762550001773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 762550001774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 762550001775 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550001776 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 762550001777 SecY translocase; Region: SecY; pfam00344 762550001778 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 762550001779 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550001780 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762550001781 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 762550001782 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 762550001783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762550001784 ATP binding site [chemical binding]; other site 762550001785 putative Mg++ binding site [ion binding]; other site 762550001786 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 762550001787 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 762550001788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550001789 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 762550001790 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 762550001791 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 762550001792 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550001793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 762550001794 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 762550001795 active site 762550001796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 762550001797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550001798 Coenzyme A binding pocket [chemical binding]; other site 762550001799 thymidylate synthase; Region: thym_sym; TIGR03284 762550001800 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 762550001801 dimerization interface [polypeptide binding]; other site 762550001802 active site 762550001803 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 762550001804 catalytic motif [active] 762550001805 Zn binding site [ion binding]; other site 762550001806 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 762550001807 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 762550001808 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 762550001809 homodimer interface [polypeptide binding]; other site 762550001810 NADP binding site [chemical binding]; other site 762550001811 substrate binding site [chemical binding]; other site 762550001812 BioY family; Region: BioY; pfam02632 762550001813 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550001814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550001815 DNA-binding site [nucleotide binding]; DNA binding site 762550001816 TrkA-C domain; Region: TrkA_C; pfam02080 762550001817 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 762550001818 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 762550001819 Walker A/P-loop; other site 762550001820 ATP binding site [chemical binding]; other site 762550001821 Q-loop/lid; other site 762550001822 ABC transporter signature motif; other site 762550001823 Walker B; other site 762550001824 D-loop; other site 762550001825 H-loop/switch region; other site 762550001826 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 762550001827 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 762550001828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550001829 dimer interface [polypeptide binding]; other site 762550001830 conserved gate region; other site 762550001831 putative PBP binding loops; other site 762550001832 ABC-ATPase subunit interface; other site 762550001833 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 762550001834 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 762550001835 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762550001836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550001837 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 762550001838 HPr interaction site; other site 762550001839 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550001840 active site 762550001841 phosphorylation site [posttranslational modification] 762550001842 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550001843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550001844 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550001845 galactokinase; Provisional; Region: PRK05322 762550001846 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 762550001847 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762550001848 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550001849 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 762550001850 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 762550001851 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 762550001852 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 762550001853 active site 762550001854 catalytic residues [active] 762550001855 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 762550001856 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 762550001857 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 762550001858 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 762550001859 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 762550001860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762550001861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550001862 active site 762550001863 catalytic tetrad [active] 762550001864 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 762550001865 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 762550001866 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 762550001867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550001868 Walker A/P-loop; other site 762550001869 ATP binding site [chemical binding]; other site 762550001870 Q-loop/lid; other site 762550001871 ABC transporter signature motif; other site 762550001872 Walker B; other site 762550001873 D-loop; other site 762550001874 H-loop/switch region; other site 762550001875 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 762550001876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001878 non-specific DNA binding site [nucleotide binding]; other site 762550001879 salt bridge; other site 762550001880 sequence-specific DNA binding site [nucleotide binding]; other site 762550001881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001883 non-specific DNA binding site [nucleotide binding]; other site 762550001884 salt bridge; other site 762550001885 sequence-specific DNA binding site [nucleotide binding]; other site 762550001886 Domain of unknown function (DUF955); Region: DUF955; pfam06114 762550001887 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 762550001888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550001889 active site 762550001890 motif I; other site 762550001891 motif II; other site 762550001892 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550001893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550001894 non-specific DNA binding site [nucleotide binding]; other site 762550001895 salt bridge; other site 762550001896 sequence-specific DNA binding site [nucleotide binding]; other site 762550001897 RNA polymerase sigma factor; Provisional; Region: PRK12519 762550001898 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 762550001899 polymerase nucleotide-binding site; other site 762550001900 DNA-binding residues [nucleotide binding]; DNA binding site 762550001901 nucleotide binding site [chemical binding]; other site 762550001902 primase nucleotide-binding site [nucleotide binding]; other site 762550001903 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 762550001904 D5 N terminal like; Region: D5_N; cl07360 762550001905 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 762550001906 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 762550001907 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762550001908 DNA binding residues [nucleotide binding] 762550001909 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 762550001910 Int/Topo IB signature motif; other site 762550001911 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 762550001912 putative deacylase active site [active] 762550001913 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 762550001914 putative uracil binding site [chemical binding]; other site 762550001915 putative active site [active] 762550001916 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 762550001917 VanW like protein; Region: VanW; pfam04294 762550001918 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 762550001919 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 762550001920 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 762550001921 NAD(P) binding site [chemical binding]; other site 762550001922 catalytic residues [active] 762550001923 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 762550001924 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 762550001925 generic binding surface II; other site 762550001926 ssDNA binding site; other site 762550001927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550001928 ATP binding site [chemical binding]; other site 762550001929 putative Mg++ binding site [ion binding]; other site 762550001930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550001931 nucleotide binding region [chemical binding]; other site 762550001932 ATP-binding site [chemical binding]; other site 762550001933 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 762550001934 MutS domain I; Region: MutS_I; pfam01624 762550001935 MutS domain II; Region: MutS_II; pfam05188 762550001936 MutS domain III; Region: MutS_III; pfam05192 762550001937 MutS domain V; Region: MutS_V; pfam00488 762550001938 Walker A/P-loop; other site 762550001939 ATP binding site [chemical binding]; other site 762550001940 Q-loop/lid; other site 762550001941 ABC transporter signature motif; other site 762550001942 Walker B; other site 762550001943 D-loop; other site 762550001944 H-loop/switch region; other site 762550001945 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 762550001946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550001947 ATP binding site [chemical binding]; other site 762550001948 Mg2+ binding site [ion binding]; other site 762550001949 G-X-G motif; other site 762550001950 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 762550001951 ATP binding site [chemical binding]; other site 762550001952 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 762550001953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 762550001954 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762550001955 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 762550001956 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 762550001957 active site 762550001958 multimer interface [polypeptide binding]; other site 762550001959 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 762550001960 FAD binding domain; Region: FAD_binding_4; pfam01565 762550001961 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 762550001962 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762550001963 Uncharacterized conserved protein [Function unknown]; Region: COG1624 762550001964 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 762550001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 762550001966 YbbR-like protein; Region: YbbR; pfam07949 762550001967 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 762550001968 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 762550001969 active site 762550001970 substrate binding site [chemical binding]; other site 762550001971 metal binding site [ion binding]; metal-binding site 762550001972 ribonuclease III; Reviewed; Region: rnc; PRK00102 762550001973 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 762550001974 dimerization interface [polypeptide binding]; other site 762550001975 active site 762550001976 metal binding site [ion binding]; metal-binding site 762550001977 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 762550001978 dsRNA binding site [nucleotide binding]; other site 762550001979 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 762550001980 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762550001981 Walker A/P-loop; other site 762550001982 ATP binding site [chemical binding]; other site 762550001983 Q-loop/lid; other site 762550001984 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 762550001985 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 762550001986 ABC transporter signature motif; other site 762550001987 Walker B; other site 762550001988 D-loop; other site 762550001989 H-loop/switch region; other site 762550001990 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 762550001991 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 762550001992 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762550001993 P loop; other site 762550001994 GTP binding site [chemical binding]; other site 762550001995 putative DNA-binding protein; Validated; Region: PRK00118 762550001996 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 762550001997 signal recognition particle protein; Provisional; Region: PRK10867 762550001998 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 762550001999 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 762550002000 P loop; other site 762550002001 GTP binding site [chemical binding]; other site 762550002002 Signal peptide binding domain; Region: SRP_SPB; pfam02978 762550002003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 762550002004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550002005 active site 762550002006 motif I; other site 762550002007 motif II; other site 762550002008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550002009 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762550002010 Predicted flavoprotein [General function prediction only]; Region: COG0431 762550002011 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 762550002012 beta-galactosidase; Region: BGL; TIGR03356 762550002013 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 762550002014 active site 762550002015 P-loop; other site 762550002016 phosphorylation site [posttranslational modification] 762550002017 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 762550002018 HTH domain; Region: HTH_11; pfam08279 762550002019 Mga helix-turn-helix domain; Region: Mga; pfam05043 762550002020 PRD domain; Region: PRD; pfam00874 762550002021 PRD domain; Region: PRD; pfam00874 762550002022 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 762550002023 active site 762550002024 P-loop; other site 762550002025 phosphorylation site [posttranslational modification] 762550002026 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 762550002027 active site 762550002028 phosphorylation site [posttranslational modification] 762550002029 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550002030 methionine cluster; other site 762550002031 active site 762550002032 phosphorylation site [posttranslational modification] 762550002033 metal binding site [ion binding]; metal-binding site 762550002034 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 762550002035 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762550002036 histidinol-phosphatase; Reviewed; Region: PRK08123 762550002037 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 762550002038 active site 762550002039 dimer interface [polypeptide binding]; other site 762550002040 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 762550002041 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762550002042 dimer interface [polypeptide binding]; other site 762550002043 motif 1; other site 762550002044 active site 762550002045 motif 2; other site 762550002046 motif 3; other site 762550002047 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 762550002048 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 762550002049 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 762550002050 histidinol dehydrogenase; Region: hisD; TIGR00069 762550002051 NAD binding site [chemical binding]; other site 762550002052 dimerization interface [polypeptide binding]; other site 762550002053 product binding site; other site 762550002054 substrate binding site [chemical binding]; other site 762550002055 zinc binding site [ion binding]; other site 762550002056 catalytic residues [active] 762550002057 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 762550002058 putative active site pocket [active] 762550002059 4-fold oligomerization interface [polypeptide binding]; other site 762550002060 metal binding residues [ion binding]; metal-binding site 762550002061 3-fold/trimer interface [polypeptide binding]; other site 762550002062 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 762550002063 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 762550002064 catalytic residues [active] 762550002065 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 762550002066 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 762550002067 substrate binding site [chemical binding]; other site 762550002068 glutamase interaction surface [polypeptide binding]; other site 762550002069 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 762550002070 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 762550002071 metal binding site [ion binding]; metal-binding site 762550002072 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 762550002073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550002074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550002075 homodimer interface [polypeptide binding]; other site 762550002076 catalytic residue [active] 762550002077 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 762550002078 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 762550002079 GDP-binding site [chemical binding]; other site 762550002080 ACT binding site; other site 762550002081 IMP binding site; other site 762550002082 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 762550002083 AAA domain; Region: AAA_30; pfam13604 762550002084 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 762550002085 Uncharacterized conserved protein [Function unknown]; Region: COG3410 762550002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550002087 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762550002088 Walker A motif; other site 762550002089 ATP binding site [chemical binding]; other site 762550002090 Walker B motif; other site 762550002091 arginine finger; other site 762550002092 UvrB/uvrC motif; Region: UVR; pfam02151 762550002093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550002094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762550002095 Walker A motif; other site 762550002096 ATP binding site [chemical binding]; other site 762550002097 Walker B motif; other site 762550002098 arginine finger; other site 762550002099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550002100 rod shape-determining protein MreB; Provisional; Region: PRK13927 762550002101 MreB and similar proteins; Region: MreB_like; cd10225 762550002102 nucleotide binding site [chemical binding]; other site 762550002103 Mg binding site [ion binding]; other site 762550002104 putative protofilament interaction site [polypeptide binding]; other site 762550002105 RodZ interaction site [polypeptide binding]; other site 762550002106 rod shape-determining protein MreC; Provisional; Region: PRK13922 762550002107 rod shape-determining protein MreC; Region: MreC; pfam04085 762550002108 rod shape-determining protein MreD; Region: MreD; cl01087 762550002109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550002110 dimer interface [polypeptide binding]; other site 762550002111 conserved gate region; other site 762550002112 putative PBP binding loops; other site 762550002113 ABC-ATPase subunit interface; other site 762550002114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550002115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550002116 Walker A/P-loop; other site 762550002117 ATP binding site [chemical binding]; other site 762550002118 Q-loop/lid; other site 762550002119 ABC transporter signature motif; other site 762550002120 Walker B; other site 762550002121 D-loop; other site 762550002122 H-loop/switch region; other site 762550002123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550002124 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550002125 substrate binding pocket [chemical binding]; other site 762550002126 membrane-bound complex binding site; other site 762550002127 hinge residues; other site 762550002128 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 762550002129 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 762550002130 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 762550002131 putative active site [active] 762550002132 catalytic site [active] 762550002133 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 762550002134 putative active site [active] 762550002135 catalytic site [active] 762550002136 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762550002137 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762550002138 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 762550002139 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 762550002140 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 762550002141 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 762550002142 Helix-turn-helix domain; Region: HTH_25; pfam13413 762550002143 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 762550002144 recombinase A; Provisional; Region: recA; PRK09354 762550002145 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 762550002146 hexamer interface [polypeptide binding]; other site 762550002147 Walker A motif; other site 762550002148 ATP binding site [chemical binding]; other site 762550002149 Walker B motif; other site 762550002150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550002151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550002152 active site 762550002153 phosphorylation site [posttranslational modification] 762550002154 intermolecular recognition site; other site 762550002155 dimerization interface [polypeptide binding]; other site 762550002156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550002157 DNA binding site [nucleotide binding] 762550002158 PBP superfamily domain; Region: PBP_like_2; cl17296 762550002159 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762550002160 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 762550002161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 762550002162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762550002163 dimer interface [polypeptide binding]; other site 762550002164 phosphorylation site [posttranslational modification] 762550002165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550002166 ATP binding site [chemical binding]; other site 762550002167 Mg2+ binding site [ion binding]; other site 762550002168 G-X-G motif; other site 762550002169 PBP superfamily domain; Region: PBP_like_2; cl17296 762550002170 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 762550002171 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 762550002172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550002173 dimer interface [polypeptide binding]; other site 762550002174 conserved gate region; other site 762550002175 putative PBP binding loops; other site 762550002176 ABC-ATPase subunit interface; other site 762550002177 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 762550002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550002179 dimer interface [polypeptide binding]; other site 762550002180 conserved gate region; other site 762550002181 putative PBP binding loops; other site 762550002182 ABC-ATPase subunit interface; other site 762550002183 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 762550002184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762550002185 Walker A/P-loop; other site 762550002186 ATP binding site [chemical binding]; other site 762550002187 Q-loop/lid; other site 762550002188 ABC transporter signature motif; other site 762550002189 Walker B; other site 762550002190 D-loop; other site 762550002191 H-loop/switch region; other site 762550002192 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 762550002193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 762550002194 Walker A/P-loop; other site 762550002195 ATP binding site [chemical binding]; other site 762550002196 Q-loop/lid; other site 762550002197 ABC transporter signature motif; other site 762550002198 Walker B; other site 762550002199 D-loop; other site 762550002200 H-loop/switch region; other site 762550002201 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 762550002202 PhoU domain; Region: PhoU; pfam01895 762550002203 PhoU domain; Region: PhoU; pfam01895 762550002204 Membrane protein of unknown function; Region: DUF360; pfam04020 762550002205 HPr kinase/phosphorylase; Provisional; Region: PRK05428 762550002206 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 762550002207 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 762550002208 Hpr binding site; other site 762550002209 active site 762550002210 homohexamer subunit interaction site [polypeptide binding]; other site 762550002211 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 762550002212 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 762550002213 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 762550002214 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 762550002215 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 762550002216 active site 762550002217 tetramer interface; other site 762550002218 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 762550002219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762550002220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550002221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550002223 putative substrate translocation pore; other site 762550002224 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 762550002225 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 762550002226 active site 762550002227 homodimer interface [polypeptide binding]; other site 762550002228 catalytic site [active] 762550002229 potential frameshift: common BLAST hit: gi|170017597|ref|YP_001728516.1| DedA family protein 762550002230 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762550002231 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762550002232 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 762550002233 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 762550002234 active site 762550002235 substrate binding site [chemical binding]; other site 762550002236 metal binding site [ion binding]; metal-binding site 762550002237 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 762550002238 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 762550002239 active site 762550002240 DNA polymerase IV; Validated; Region: PRK02406 762550002241 DNA binding site [nucleotide binding] 762550002242 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 762550002243 DHH family; Region: DHH; pfam01368 762550002244 DHHA1 domain; Region: DHHA1; pfam02272 762550002245 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762550002246 DEAD-like helicases superfamily; Region: DEXDc; smart00487 762550002247 ATP binding site [chemical binding]; other site 762550002248 Mg++ binding site [ion binding]; other site 762550002249 motif III; other site 762550002250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550002251 nucleotide binding region [chemical binding]; other site 762550002252 ATP-binding site [chemical binding]; other site 762550002253 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 762550002254 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 762550002255 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 762550002256 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 762550002257 acyl-activating enzyme (AAE) consensus motif; other site 762550002258 AMP binding site [chemical binding]; other site 762550002259 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 762550002260 Phosphopantetheine attachment site; Region: PP-binding; cl09936 762550002261 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 762550002262 DltD N-terminal region; Region: DltD_N; pfam04915 762550002263 DltD central region; Region: DltD_M; pfam04918 762550002264 DltD C-terminal region; Region: DltD_C; pfam04914 762550002265 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 762550002266 glutamate racemase; Provisional; Region: PRK00865 762550002267 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762550002268 active site 762550002269 dimerization interface [polypeptide binding]; other site 762550002270 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 762550002271 active site 762550002272 metal binding site [ion binding]; metal-binding site 762550002273 homotetramer interface [polypeptide binding]; other site 762550002274 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 762550002275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550002276 Walker A motif; other site 762550002277 ATP binding site [chemical binding]; other site 762550002278 Walker B motif; other site 762550002279 arginine finger; other site 762550002280 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 762550002281 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 762550002282 putative active site [active] 762550002283 putative metal binding site [ion binding]; other site 762550002284 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 762550002285 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 762550002286 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 762550002287 RuvA N terminal domain; Region: RuvA_N; pfam01330 762550002288 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 762550002289 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 762550002290 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 762550002291 Substrate-binding site [chemical binding]; other site 762550002292 Substrate specificity [chemical binding]; other site 762550002293 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 762550002294 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 762550002295 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 762550002296 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 762550002297 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 762550002298 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 762550002299 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 762550002300 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 762550002301 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 762550002302 putative substrate binding site [chemical binding]; other site 762550002303 putative ATP binding site [chemical binding]; other site 762550002304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762550002305 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 762550002306 active site 762550002307 phosphorylation site [posttranslational modification] 762550002308 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 762550002309 active site 762550002310 P-loop; other site 762550002311 phosphorylation site [posttranslational modification] 762550002312 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 762550002313 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762550002314 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762550002315 DNA binding site [nucleotide binding] 762550002316 active site 762550002317 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 762550002318 RimM N-terminal domain; Region: RimM; pfam01782 762550002319 PRC-barrel domain; Region: PRC; pfam05239 762550002320 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 762550002321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002322 non-specific DNA binding site [nucleotide binding]; other site 762550002323 salt bridge; other site 762550002324 sequence-specific DNA binding site [nucleotide binding]; other site 762550002325 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762550002326 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550002327 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 762550002328 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002329 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762550002330 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762550002331 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 762550002332 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002333 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002334 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002335 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550002336 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 762550002337 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 762550002338 Chain length determinant protein; Region: Wzz; cl15801 762550002339 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 762550002340 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 762550002341 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 762550002342 Nucleotide binding site [chemical binding]; other site 762550002343 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762550002344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550002345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550002346 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 762550002347 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 762550002348 putative ADP-binding pocket [chemical binding]; other site 762550002349 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762550002350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550002351 active site 762550002352 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 762550002353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 762550002354 active site 762550002355 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762550002356 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 762550002357 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 762550002358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550002359 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 762550002360 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 762550002361 NADP binding site [chemical binding]; other site 762550002362 active site 762550002363 putative substrate binding site [chemical binding]; other site 762550002364 Uncharacterized conserved protein [Function unknown]; Region: COG2966 762550002365 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 762550002366 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 762550002367 myosin-cross-reactive antigen; Provisional; Region: PRK13977 762550002368 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 762550002369 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 762550002370 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 762550002371 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 762550002372 ribonuclease Z; Region: RNase_Z; TIGR02651 762550002373 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 762550002374 DHH family; Region: DHH; pfam01368 762550002375 DHHA1 domain; Region: DHHA1; pfam02272 762550002376 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 762550002377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550002378 active site 762550002379 Thioredoxin; Region: Thioredoxin_5; pfam13743 762550002380 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762550002381 synthetase active site [active] 762550002382 NTP binding site [chemical binding]; other site 762550002383 metal binding site [ion binding]; metal-binding site 762550002384 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 762550002385 ATP-NAD kinase; Region: NAD_kinase; pfam01513 762550002386 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762550002387 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762550002388 active site 762550002389 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 762550002390 MgtE intracellular N domain; Region: MgtE_N; pfam03448 762550002391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 762550002392 Divalent cation transporter; Region: MgtE; pfam01769 762550002393 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550002394 argininosuccinate synthase; Provisional; Region: PRK13820 762550002395 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 762550002396 ANP binding site [chemical binding]; other site 762550002397 Substrate Binding Site II [chemical binding]; other site 762550002398 Substrate Binding Site I [chemical binding]; other site 762550002399 argininosuccinate lyase; Provisional; Region: PRK00855 762550002400 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 762550002401 active sites [active] 762550002402 tetramer interface [polypeptide binding]; other site 762550002403 ornithine carbamoyltransferase; Validated; Region: PRK02102 762550002404 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762550002405 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762550002406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550002408 putative substrate translocation pore; other site 762550002409 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 762550002410 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 762550002411 metal binding site [ion binding]; metal-binding site 762550002412 dimer interface [polypeptide binding]; other site 762550002413 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 762550002414 Domain of unknown function (DUF814); Region: DUF814; pfam05670 762550002415 CutC family; Region: CutC; cl01218 762550002416 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 762550002417 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762550002418 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 762550002419 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 762550002420 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 762550002421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550002422 non-specific DNA binding site [nucleotide binding]; other site 762550002423 salt bridge; other site 762550002424 sequence-specific DNA binding site [nucleotide binding]; other site 762550002425 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 762550002426 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 762550002427 active site 762550002428 diaminopimelate decarboxylase; Region: lysA; TIGR01048 762550002429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 762550002430 active site 762550002431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550002432 substrate binding site [chemical binding]; other site 762550002433 catalytic residues [active] 762550002434 dimer interface [polypeptide binding]; other site 762550002435 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 762550002436 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 762550002437 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762550002438 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 762550002439 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 762550002440 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 762550002441 metal binding site [ion binding]; metal-binding site 762550002442 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 762550002443 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 762550002444 dimer interface [polypeptide binding]; other site 762550002445 active site 762550002446 catalytic residue [active] 762550002447 dihydrodipicolinate reductase; Provisional; Region: PRK00048 762550002448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 762550002449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 762550002450 RecX family; Region: RecX; cl00936 762550002451 hypothetical protein; Provisional; Region: PRK13662 762550002452 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 762550002453 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762550002454 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 762550002455 Part of AAA domain; Region: AAA_19; pfam13245 762550002456 Family description; Region: UvrD_C_2; pfam13538 762550002457 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 762550002458 Rhomboid family; Region: Rhomboid; pfam01694 762550002459 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 762550002460 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 762550002461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762550002462 nucleotide binding site [chemical binding]; other site 762550002463 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 762550002464 active site 762550002465 Bacterial sugar transferase; Region: Bac_transf; pfam02397 762550002466 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 762550002467 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 762550002468 Surface antigen [General function prediction only]; Region: COG3942 762550002469 CHAP domain; Region: CHAP; cl17642 762550002470 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 762550002471 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762550002472 UDP-galactopyranose mutase; Region: GLF; pfam03275 762550002473 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 762550002474 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 762550002475 Ligand binding site; other site 762550002476 Putative Catalytic site; other site 762550002477 DXD motif; other site 762550002478 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550002479 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 762550002480 active site 762550002481 nucleotide binding site [chemical binding]; other site 762550002482 HIGH motif; other site 762550002483 KMSKS motif; other site 762550002484 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 762550002485 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 762550002486 Probable Catalytic site; other site 762550002487 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762550002488 DNA-binding site [nucleotide binding]; DNA binding site 762550002489 RNA-binding motif; other site 762550002490 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 762550002491 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 762550002492 dimer interface [polypeptide binding]; other site 762550002493 ADP-ribose binding site [chemical binding]; other site 762550002494 active site 762550002495 nudix motif; other site 762550002496 metal binding site [ion binding]; metal-binding site 762550002497 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 762550002498 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 762550002499 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762550002500 putative tRNA-binding site [nucleotide binding]; other site 762550002501 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 762550002502 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762550002503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550002504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762550002505 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 762550002506 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 762550002507 DNA polymerase I; Provisional; Region: PRK05755 762550002508 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 762550002509 active site 762550002510 metal binding site 1 [ion binding]; metal-binding site 762550002511 putative 5' ssDNA interaction site; other site 762550002512 metal binding site 3; metal-binding site 762550002513 metal binding site 2 [ion binding]; metal-binding site 762550002514 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 762550002515 putative DNA binding site [nucleotide binding]; other site 762550002516 putative metal binding site [ion binding]; other site 762550002517 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 762550002518 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 762550002519 active site 762550002520 DNA binding site [nucleotide binding] 762550002521 catalytic site [active] 762550002522 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762550002523 DNA binding residues [nucleotide binding] 762550002524 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 762550002525 putative dimer interface [polypeptide binding]; other site 762550002526 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 762550002527 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 762550002528 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 762550002529 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550002530 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550002531 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762550002532 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 762550002533 active site 1 [active] 762550002534 dimer interface [polypeptide binding]; other site 762550002535 hexamer interface [polypeptide binding]; other site 762550002536 active site 2 [active] 762550002537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550002538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550002539 DNA binding site [nucleotide binding] 762550002540 domain linker motif; other site 762550002541 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550002542 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 762550002543 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 762550002544 active site turn [active] 762550002545 phosphorylation site [posttranslational modification] 762550002546 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 762550002547 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 762550002548 HPr interaction site; other site 762550002549 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550002550 active site 762550002551 phosphorylation site [posttranslational modification] 762550002552 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 762550002553 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 762550002554 substrate binding [chemical binding]; other site 762550002555 active site 762550002556 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 762550002557 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550002558 active site 762550002559 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762550002560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550002561 RNA binding surface [nucleotide binding]; other site 762550002562 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762550002563 active site 762550002564 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 762550002565 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550002566 active site 762550002567 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 762550002568 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 762550002569 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762550002570 catalytic site [active] 762550002571 subunit interface [polypeptide binding]; other site 762550002572 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 762550002573 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762550002574 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762550002575 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 762550002576 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550002577 drug efflux system protein MdtG; Provisional; Region: PRK09874 762550002578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550002579 putative substrate translocation pore; other site 762550002580 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 762550002581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550002582 Zn2+ binding site [ion binding]; other site 762550002583 Mg2+ binding site [ion binding]; other site 762550002584 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 762550002585 synthetase active site [active] 762550002586 NTP binding site [chemical binding]; other site 762550002587 metal binding site [ion binding]; metal-binding site 762550002588 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 762550002589 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 762550002590 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 762550002591 putative active site [active] 762550002592 dimerization interface [polypeptide binding]; other site 762550002593 putative tRNAtyr binding site [nucleotide binding]; other site 762550002594 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 762550002595 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 762550002596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550002597 ATP binding site [chemical binding]; other site 762550002598 Mg2+ binding site [ion binding]; other site 762550002599 G-X-G motif; other site 762550002600 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 762550002601 anchoring element; other site 762550002602 dimer interface [polypeptide binding]; other site 762550002603 ATP binding site [chemical binding]; other site 762550002604 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 762550002605 active site 762550002606 putative metal-binding site [ion binding]; other site 762550002607 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 762550002608 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 762550002609 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 762550002610 CAP-like domain; other site 762550002611 active site 762550002612 primary dimer interface [polypeptide binding]; other site 762550002613 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 762550002614 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 762550002615 DHH family; Region: DHH; pfam01368 762550002616 DHHA2 domain; Region: DHHA2; pfam02833 762550002617 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 762550002618 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 762550002619 ribosome maturation protein RimP; Reviewed; Region: PRK00092 762550002620 Sm and related proteins; Region: Sm_like; cl00259 762550002621 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 762550002622 putative oligomer interface [polypeptide binding]; other site 762550002623 putative RNA binding site [nucleotide binding]; other site 762550002624 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 762550002625 NusA N-terminal domain; Region: NusA_N; pfam08529 762550002626 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 762550002627 RNA binding site [nucleotide binding]; other site 762550002628 homodimer interface [polypeptide binding]; other site 762550002629 NusA-like KH domain; Region: KH_5; pfam13184 762550002630 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 762550002631 G-X-X-G motif; other site 762550002632 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 762550002633 putative RNA binding cleft [nucleotide binding]; other site 762550002634 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 762550002635 translation initiation factor IF-2; Region: IF-2; TIGR00487 762550002636 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 762550002637 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 762550002638 G1 box; other site 762550002639 putative GEF interaction site [polypeptide binding]; other site 762550002640 GTP/Mg2+ binding site [chemical binding]; other site 762550002641 Switch I region; other site 762550002642 G2 box; other site 762550002643 G3 box; other site 762550002644 Switch II region; other site 762550002645 G4 box; other site 762550002646 G5 box; other site 762550002647 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 762550002648 Translation-initiation factor 2; Region: IF-2; pfam11987 762550002649 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 762550002650 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 762550002651 aromatic amino acid aminotransferase; Validated; Region: PRK07309 762550002652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550002653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550002654 homodimer interface [polypeptide binding]; other site 762550002655 catalytic residue [active] 762550002656 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 762550002657 glycerol kinase (GK) interaction site [polypeptide binding]; other site 762550002658 HPr interaction site; other site 762550002659 active site 762550002660 phosphorylation site [posttranslational modification] 762550002661 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 762550002662 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 762550002663 RNA binding site [nucleotide binding]; other site 762550002664 active site 762550002665 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 762550002666 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 762550002667 active site 762550002668 Riboflavin kinase; Region: Flavokinase; smart00904 762550002669 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 762550002670 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 762550002671 heat shock protein GrpE; Provisional; Region: PRK14140 762550002672 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 762550002673 dimer interface [polypeptide binding]; other site 762550002674 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 762550002675 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 762550002676 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 762550002677 nucleotide binding site [chemical binding]; other site 762550002678 NEF interaction site [polypeptide binding]; other site 762550002679 SBD interface [polypeptide binding]; other site 762550002680 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 762550002681 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 762550002682 HSP70 interaction site [polypeptide binding]; other site 762550002683 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 762550002684 substrate binding site [polypeptide binding]; other site 762550002685 dimer interface [polypeptide binding]; other site 762550002686 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 762550002687 active site 762550002688 catalytic residues [active] 762550002689 metal binding site [ion binding]; metal-binding site 762550002690 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 762550002691 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 762550002692 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 762550002693 active site 762550002694 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 762550002695 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 762550002696 G1 box; other site 762550002697 putative GEF interaction site [polypeptide binding]; other site 762550002698 GTP/Mg2+ binding site [chemical binding]; other site 762550002699 Switch I region; other site 762550002700 G2 box; other site 762550002701 G3 box; other site 762550002702 Switch II region; other site 762550002703 G4 box; other site 762550002704 G5 box; other site 762550002705 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 762550002706 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 762550002707 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 762550002708 active site 762550002709 catalytic triad [active] 762550002710 oxyanion hole [active] 762550002711 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 762550002712 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 762550002713 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762550002714 active site 762550002715 metal binding site [ion binding]; metal-binding site 762550002716 DNA binding site [nucleotide binding] 762550002717 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762550002718 Uncharacterized conserved protein [Function unknown]; Region: COG4717 762550002719 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 762550002720 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 762550002721 generic binding surface II; other site 762550002722 generic binding surface I; other site 762550002723 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 762550002724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550002725 Zn2+ binding site [ion binding]; other site 762550002726 Mg2+ binding site [ion binding]; other site 762550002727 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 762550002728 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 762550002729 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 762550002730 HIT family signature motif; other site 762550002731 catalytic residue [active] 762550002732 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 762550002733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 762550002734 Walker A/P-loop; other site 762550002735 ATP binding site [chemical binding]; other site 762550002736 Q-loop/lid; other site 762550002737 ABC transporter signature motif; other site 762550002738 Walker B; other site 762550002739 D-loop; other site 762550002740 H-loop/switch region; other site 762550002741 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 762550002742 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 762550002743 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 762550002744 Terminase small subunit; Region: Terminase_2; pfam03592 762550002745 Phage terminase large subunit; Region: Terminase_3; cl12054 762550002746 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 762550002747 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 762550002748 MepB protein; Region: MepB; pfam08877 762550002749 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 762550002750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550002751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550002752 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 762550002753 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 762550002754 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 762550002755 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762550002756 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762550002757 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762550002758 active site 762550002759 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762550002760 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 762550002761 active site 762550002762 metal binding site [ion binding]; metal-binding site 762550002763 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762550002764 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 762550002765 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 762550002766 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 762550002767 homodimer interface [polypeptide binding]; other site 762550002768 substrate-cofactor binding pocket; other site 762550002769 catalytic residue [active] 762550002770 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762550002771 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762550002772 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 762550002773 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550002774 NAD binding site [chemical binding]; other site 762550002775 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762550002776 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 762550002777 putative active site [active] 762550002778 catalytic site [active] 762550002779 putative metal binding site [ion binding]; other site 762550002780 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762550002781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762550002782 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 762550002783 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 762550002784 FMN binding site [chemical binding]; other site 762550002785 active site 762550002786 catalytic residues [active] 762550002787 substrate binding site [chemical binding]; other site 762550002788 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 762550002789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550002790 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 762550002791 HicB family; Region: HicB; pfam05534 762550002792 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 762550002793 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 762550002794 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 762550002795 Flavoprotein; Region: Flavoprotein; pfam02441 762550002796 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 762550002797 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 762550002798 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 762550002799 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 762550002800 active site 762550002801 HIGH motif; other site 762550002802 KMSK motif region; other site 762550002803 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 762550002804 tRNA binding surface [nucleotide binding]; other site 762550002805 anticodon binding site; other site 762550002806 Arginine repressor [Transcription]; Region: ArgR; COG1438 762550002807 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762550002808 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762550002809 Transglycosylase; Region: Transgly; pfam00912 762550002810 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 762550002811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762550002812 Protein of unknown function (DUF964); Region: DUF964; cl01483 762550002813 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 762550002814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762550002815 Catalytic site [active] 762550002816 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 762550002817 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 762550002818 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 762550002819 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 762550002820 dihydroorotase; Validated; Region: pyrC; PRK09357 762550002821 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 762550002822 active site 762550002823 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 762550002824 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 762550002825 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 762550002826 catalytic site [active] 762550002827 subunit interface [polypeptide binding]; other site 762550002828 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 762550002829 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550002830 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 762550002831 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 762550002832 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550002833 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762550002834 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 762550002835 IMP binding site; other site 762550002836 dimer interface [polypeptide binding]; other site 762550002837 interdomain contacts; other site 762550002838 partial ornithine binding site; other site 762550002839 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 762550002840 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 762550002841 heterodimer interface [polypeptide binding]; other site 762550002842 active site 762550002843 FMN binding site [chemical binding]; other site 762550002844 homodimer interface [polypeptide binding]; other site 762550002845 substrate binding site [chemical binding]; other site 762550002846 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 762550002847 active site 762550002848 dimer interface [polypeptide binding]; other site 762550002849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550002850 active site 762550002851 LexA repressor; Validated; Region: PRK00215 762550002852 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 762550002853 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 762550002854 Catalytic site [active] 762550002855 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 762550002856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 762550002857 putative acyl-acceptor binding pocket; other site 762550002858 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 762550002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550002860 S-adenosylmethionine binding site [chemical binding]; other site 762550002861 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 762550002862 GIY-YIG motif/motif A; other site 762550002863 putative active site [active] 762550002864 putative metal binding site [ion binding]; other site 762550002865 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 762550002866 rRNA interaction site [nucleotide binding]; other site 762550002867 S8 interaction site; other site 762550002868 putative laminin-1 binding site; other site 762550002869 elongation factor Ts; Provisional; Region: tsf; PRK09377 762550002870 UBA/TS-N domain; Region: UBA; pfam00627 762550002871 Elongation factor TS; Region: EF_TS; pfam00889 762550002872 Elongation factor TS; Region: EF_TS; pfam00889 762550002873 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 762550002874 putative nucleotide binding site [chemical binding]; other site 762550002875 uridine monophosphate binding site [chemical binding]; other site 762550002876 homohexameric interface [polypeptide binding]; other site 762550002877 ribosome recycling factor; Reviewed; Region: frr; PRK00083 762550002878 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 762550002879 hinge region; other site 762550002880 Predicted membrane protein [Function unknown]; Region: COG3152 762550002881 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 762550002882 motif 1; other site 762550002883 dimer interface [polypeptide binding]; other site 762550002884 active site 762550002885 motif 2; other site 762550002886 motif 3; other site 762550002887 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 762550002888 putative oxidoreductase; Provisional; Region: PRK10206 762550002889 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762550002890 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 762550002891 GTP-binding protein LepA; Provisional; Region: PRK05433 762550002892 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 762550002893 G1 box; other site 762550002894 putative GEF interaction site [polypeptide binding]; other site 762550002895 GTP/Mg2+ binding site [chemical binding]; other site 762550002896 Switch I region; other site 762550002897 G2 box; other site 762550002898 G3 box; other site 762550002899 Switch II region; other site 762550002900 G4 box; other site 762550002901 G5 box; other site 762550002902 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 762550002903 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 762550002904 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 762550002905 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 762550002906 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 762550002907 putative NAD(P) binding site [chemical binding]; other site 762550002908 dimer interface [polypeptide binding]; other site 762550002909 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 762550002910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550002911 S-adenosylmethionine binding site [chemical binding]; other site 762550002912 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 762550002913 RNA methyltransferase, RsmE family; Region: TIGR00046 762550002914 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 762550002915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550002916 Walker A/P-loop; other site 762550002917 ATP binding site [chemical binding]; other site 762550002918 Q-loop/lid; other site 762550002919 ABC transporter signature motif; other site 762550002920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550002921 Walker B; other site 762550002922 D-loop; other site 762550002923 ABC transporter; Region: ABC_tran_2; pfam12848 762550002924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550002925 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 762550002926 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 762550002927 dimer interface [polypeptide binding]; other site 762550002928 active site 762550002929 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 762550002930 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 762550002931 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 762550002932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762550002933 active site 762550002934 DNA binding site [nucleotide binding] 762550002935 Int/Topo IB signature motif; other site 762550002936 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 762550002937 active site 762550002938 catalytic residues [active] 762550002939 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 762550002940 active site 762550002941 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 762550002942 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 762550002943 active site 762550002944 dimerization interface [polypeptide binding]; other site 762550002945 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 762550002946 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 762550002947 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 762550002948 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762550002949 RNA binding site [nucleotide binding]; other site 762550002950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550002951 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762550002952 Coenzyme A binding pocket [chemical binding]; other site 762550002953 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550002954 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550002955 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762550002956 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550002957 dimer interface [polypeptide binding]; other site 762550002958 substrate binding site [chemical binding]; other site 762550002959 ATP binding site [chemical binding]; other site 762550002960 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 762550002961 chorismate binding enzyme; Region: Chorismate_bind; cl10555 762550002962 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 762550002963 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 762550002964 dimer interface [polypeptide binding]; other site 762550002965 tetramer interface [polypeptide binding]; other site 762550002966 PYR/PP interface [polypeptide binding]; other site 762550002967 TPP binding site [chemical binding]; other site 762550002968 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 762550002969 TPP-binding site; other site 762550002970 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 762550002971 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 762550002972 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 762550002973 metal binding site [ion binding]; metal-binding site 762550002974 substrate binding pocket [chemical binding]; other site 762550002975 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 762550002976 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 762550002977 dimer interface [polypeptide binding]; other site 762550002978 active site 762550002979 metal binding site [ion binding]; metal-binding site 762550002980 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 762550002981 Family of unknown function (DUF633); Region: DUF633; pfam04816 762550002982 Uncharacterized conserved protein [Function unknown]; Region: COG0327 762550002983 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 762550002984 peptidase T; Region: peptidase-T; TIGR01882 762550002985 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 762550002986 metal binding site [ion binding]; metal-binding site 762550002987 dimer interface [polypeptide binding]; other site 762550002988 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762550002989 active site 762550002990 catalytic triad [active] 762550002991 oxyanion hole [active] 762550002992 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 762550002993 hypothetical protein; Provisional; Region: PRK13672 762550002994 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 762550002995 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 762550002996 GTP/Mg2+ binding site [chemical binding]; other site 762550002997 G4 box; other site 762550002998 G5 box; other site 762550002999 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 762550003000 G1 box; other site 762550003001 G1 box; other site 762550003002 GTP/Mg2+ binding site [chemical binding]; other site 762550003003 Switch I region; other site 762550003004 G2 box; other site 762550003005 G2 box; other site 762550003006 G3 box; other site 762550003007 G3 box; other site 762550003008 Switch II region; other site 762550003009 Switch II region; other site 762550003010 G4 box; other site 762550003011 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 762550003012 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550003013 active site 762550003014 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 762550003015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 762550003016 ligand binding site [chemical binding]; other site 762550003017 flexible hinge region; other site 762550003018 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 762550003019 non-specific DNA interactions [nucleotide binding]; other site 762550003020 DNA binding site [nucleotide binding] 762550003021 sequence specific DNA binding site [nucleotide binding]; other site 762550003022 putative cAMP binding site [chemical binding]; other site 762550003023 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 762550003024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762550003025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550003026 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550003027 Domain of unknown function DUF77; Region: DUF77; pfam01910 762550003028 Protein of unknown function, DUF606; Region: DUF606; pfam04657 762550003029 Protein of unknown function, DUF606; Region: DUF606; pfam04657 762550003030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 762550003031 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 762550003032 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 762550003033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550003034 S-adenosylmethionine binding site [chemical binding]; other site 762550003035 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762550003036 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 762550003037 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 762550003038 Predicted membrane protein [Function unknown]; Region: COG2261 762550003039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762550003040 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550003041 active site 762550003042 catalytic tetrad [active] 762550003043 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 762550003044 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 762550003045 putative active site [active] 762550003046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 762550003047 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 762550003048 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 762550003049 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 762550003050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 762550003051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 762550003052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 762550003053 dimerization interface [polypeptide binding]; other site 762550003054 malate dehydrogenase; Provisional; Region: PRK13529 762550003055 Malic enzyme, N-terminal domain; Region: malic; pfam00390 762550003056 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 762550003057 NAD(P) binding site [chemical binding]; other site 762550003058 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 762550003059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 762550003060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003061 putative substrate translocation pore; other site 762550003062 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550003063 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 762550003064 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762550003065 active site 762550003066 metal binding site [ion binding]; metal-binding site 762550003067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550003068 Coenzyme A binding pocket [chemical binding]; other site 762550003069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550003070 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762550003071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550003072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550003073 Walker A/P-loop; other site 762550003074 ATP binding site [chemical binding]; other site 762550003075 Q-loop/lid; other site 762550003076 ABC transporter signature motif; other site 762550003077 Walker B; other site 762550003078 D-loop; other site 762550003079 H-loop/switch region; other site 762550003080 Predicted membrane protein [Function unknown]; Region: COG2261 762550003081 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 762550003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 762550003083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003084 sequence-specific DNA binding site [nucleotide binding]; other site 762550003085 salt bridge; other site 762550003086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003087 putative substrate translocation pore; other site 762550003088 H+ Antiporter protein; Region: 2A0121; TIGR00900 762550003089 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 762550003090 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 762550003091 NAD binding site [chemical binding]; other site 762550003092 catalytic residues [active] 762550003093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550003095 putative substrate translocation pore; other site 762550003096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550003097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550003098 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 762550003099 conserved cys residue [active] 762550003100 LssY C-terminus; Region: LssY_C; pfam14067 762550003101 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 762550003102 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762550003103 NAD(P) binding site [chemical binding]; other site 762550003104 SAP domain; Region: SAP; pfam02037 762550003105 SnoaL-like domain; Region: SnoaL_2; pfam12680 762550003106 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 762550003107 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 762550003108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003109 non-specific DNA binding site [nucleotide binding]; other site 762550003110 salt bridge; other site 762550003111 sequence-specific DNA binding site [nucleotide binding]; other site 762550003112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550003113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003114 non-specific DNA binding site [nucleotide binding]; other site 762550003115 salt bridge; other site 762550003116 sequence-specific DNA binding site [nucleotide binding]; other site 762550003117 potential frameshift: common BLAST hit: gi|116618146|ref|YP_818517.1| transcriptional regulator 762550003118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003119 non-specific DNA binding site [nucleotide binding]; other site 762550003120 salt bridge; other site 762550003121 sequence-specific DNA binding site [nucleotide binding]; other site 762550003122 potential frameshift: common BLAST hit: gi|170017219|ref|YP_001728138.1| transcriptional regulator 762550003123 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550003124 Helix-turn-helix domain; Region: HTH_38; pfam13936 762550003125 Integrase core domain; Region: rve; pfam00665 762550003126 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 762550003127 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 762550003128 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 762550003129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550003130 ATP binding site [chemical binding]; other site 762550003131 putative Mg++ binding site [ion binding]; other site 762550003132 HsdM N-terminal domain; Region: HsdM_N; pfam12161 762550003133 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 762550003134 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762550003135 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762550003136 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 762550003137 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 762550003138 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 762550003139 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 762550003140 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 762550003141 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 762550003142 CHAP domain; Region: CHAP; pfam05257 762550003143 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550003144 catalytic residues [active] 762550003145 AAA-like domain; Region: AAA_10; pfam12846 762550003146 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 762550003147 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762550003148 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 762550003149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003150 non-specific DNA binding site [nucleotide binding]; other site 762550003151 salt bridge; other site 762550003152 sequence-specific DNA binding site [nucleotide binding]; other site 762550003153 Replication initiation factor; Region: Rep_trans; pfam02486 762550003154 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550003155 Helix-turn-helix domain; Region: HTH_38; pfam13936 762550003156 Integrase core domain; Region: rve; pfam00665 762550003157 DNA polymerase IV; Reviewed; Region: PRK03103 762550003158 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762550003159 active site 762550003160 DNA binding site [nucleotide binding] 762550003161 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 762550003162 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 762550003163 putative dimer interface [polypeptide binding]; other site 762550003164 catalytic triad [active] 762550003165 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 762550003166 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762550003167 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 762550003168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003169 Walker A/P-loop; other site 762550003170 ATP binding site [chemical binding]; other site 762550003171 Q-loop/lid; other site 762550003172 ABC transporter signature motif; other site 762550003173 Walker B; other site 762550003174 D-loop; other site 762550003175 H-loop/switch region; other site 762550003176 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 762550003177 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 762550003178 GntP family permease; Region: GntP_permease; pfam02447 762550003179 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762550003180 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 762550003181 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 762550003182 NADP binding site [chemical binding]; other site 762550003183 homodimer interface [polypeptide binding]; other site 762550003184 active site 762550003185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003187 DNA binding site [nucleotide binding] 762550003188 domain linker motif; other site 762550003189 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550003190 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 762550003191 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003192 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 762550003193 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 762550003194 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003195 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003196 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003197 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003198 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550003199 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550003200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003201 non-specific DNA binding site [nucleotide binding]; other site 762550003202 salt bridge; other site 762550003203 sequence-specific DNA binding site [nucleotide binding]; other site 762550003204 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 762550003205 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 762550003206 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 762550003207 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550003208 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 762550003209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550003210 motif II; other site 762550003211 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 762550003212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550003213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762550003214 active site 762550003215 catalytic tetrad [active] 762550003216 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762550003217 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 762550003218 catalytic residues [active] 762550003219 dimer interface [polypeptide binding]; other site 762550003220 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 762550003221 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762550003222 putative NAD(P) binding site [chemical binding]; other site 762550003223 catalytic Zn binding site [ion binding]; other site 762550003224 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 762550003225 classical (c) SDRs; Region: SDR_c; cd05233 762550003226 NAD(P) binding site [chemical binding]; other site 762550003227 active site 762550003228 QueT transporter; Region: QueT; pfam06177 762550003229 HeH/LEM domain; Region: HeH; pfam12949 762550003230 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 762550003231 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 762550003232 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 762550003233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550003234 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 762550003235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 762550003236 DNA binding residues [nucleotide binding] 762550003237 DNA primase; Validated; Region: dnaG; PRK05667 762550003238 CHC2 zinc finger; Region: zf-CHC2; cl17510 762550003239 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 762550003240 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 762550003241 active site 762550003242 metal binding site [ion binding]; metal-binding site 762550003243 interdomain interaction site; other site 762550003244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 762550003245 MarR family; Region: MarR_2; pfam12802 762550003246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550003247 Coenzyme A binding pocket [chemical binding]; other site 762550003248 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 762550003249 putative active site [active] 762550003250 DNA polymerase IV; Reviewed; Region: PRK03103 762550003251 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 762550003252 active site 762550003253 DNA binding site [nucleotide binding] 762550003254 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 762550003255 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 762550003256 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 762550003257 trimer interface [polypeptide binding]; other site 762550003258 active site 762550003259 substrate binding site [chemical binding]; other site 762550003260 CoA binding site [chemical binding]; other site 762550003261 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 762550003262 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 762550003263 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 762550003264 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 762550003265 DNA binding site [nucleotide binding] 762550003266 active site 762550003267 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 762550003268 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 762550003269 tetramer interface [polypeptide binding]; other site 762550003270 active site 762550003271 Mg2+/Mn2+ binding site [ion binding]; other site 762550003272 hypothetical protein; Validated; Region: PRK06769 762550003273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550003274 active site 762550003275 motif I; other site 762550003276 motif II; other site 762550003277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003278 Walker A/P-loop; other site 762550003279 ATP binding site [chemical binding]; other site 762550003280 Q-loop/lid; other site 762550003281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003282 ABC transporter signature motif; other site 762550003283 Walker B; other site 762550003284 D-loop; other site 762550003285 H-loop/switch region; other site 762550003286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003287 AAA domain; Region: AAA_21; pfam13304 762550003288 Walker A/P-loop; other site 762550003289 ATP binding site [chemical binding]; other site 762550003290 Q-loop/lid; other site 762550003291 ABC transporter signature motif; other site 762550003292 Walker B; other site 762550003293 D-loop; other site 762550003294 H-loop/switch region; other site 762550003295 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550003296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550003297 Transposase; Region: HTH_Tnp_1; cl17663 762550003298 Helix-turn-helix domain; Region: HTH_28; pfam13518 762550003299 Homeodomain-like domain; Region: HTH_32; pfam13565 762550003300 putative transposase OrfB; Reviewed; Region: PHA02517 762550003301 HTH-like domain; Region: HTH_21; pfam13276 762550003302 Integrase core domain; Region: rve; pfam00665 762550003303 Integrase core domain; Region: rve_2; pfam13333 762550003304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550003305 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 762550003306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003307 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 762550003308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003309 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 762550003310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003311 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003312 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550003314 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 762550003315 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 762550003316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003317 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003318 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 762550003319 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 762550003320 Cl- selectivity filter; other site 762550003321 Cl- binding residues [ion binding]; other site 762550003322 pore gating glutamate residue; other site 762550003323 dimer interface [polypeptide binding]; other site 762550003324 H+/Cl- coupling transport residue; other site 762550003325 TrkA-C domain; Region: TrkA_C; pfam02080 762550003326 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550003327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550003328 non-specific DNA binding site [nucleotide binding]; other site 762550003329 salt bridge; other site 762550003330 sequence-specific DNA binding site [nucleotide binding]; other site 762550003331 Cupin domain; Region: Cupin_2; pfam07883 762550003332 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 762550003333 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 762550003334 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 762550003335 PYR/PP interface [polypeptide binding]; other site 762550003336 dimer interface [polypeptide binding]; other site 762550003337 tetramer interface [polypeptide binding]; other site 762550003338 TPP binding site [chemical binding]; other site 762550003339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 762550003340 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 762550003341 TPP-binding site [chemical binding]; other site 762550003342 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003343 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762550003344 Ca binding site [ion binding]; other site 762550003345 active site 762550003346 catalytic site [active] 762550003347 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762550003348 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 762550003349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550003350 Coenzyme A binding pocket [chemical binding]; other site 762550003351 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 762550003352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 762550003353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762550003354 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762550003355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550003356 dimer interface [polypeptide binding]; other site 762550003357 conserved gate region; other site 762550003358 putative PBP binding loops; other site 762550003359 ABC-ATPase subunit interface; other site 762550003360 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 762550003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550003362 dimer interface [polypeptide binding]; other site 762550003363 conserved gate region; other site 762550003364 putative PBP binding loops; other site 762550003365 ABC-ATPase subunit interface; other site 762550003366 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 762550003367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003368 Walker A/P-loop; other site 762550003369 ATP binding site [chemical binding]; other site 762550003370 Q-loop/lid; other site 762550003371 ABC transporter signature motif; other site 762550003372 Walker B; other site 762550003373 D-loop; other site 762550003374 H-loop/switch region; other site 762550003375 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 762550003376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003377 putative substrate translocation pore; other site 762550003378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003379 Collagen binding domain; Region: Collagen_bind; pfam05737 762550003380 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 762550003381 domain interaction interfaces [polypeptide binding]; other site 762550003382 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 762550003383 domain interaction interfaces [polypeptide binding]; other site 762550003384 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 762550003385 N-glycosyltransferase; Provisional; Region: PRK11204 762550003386 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 762550003387 DXD motif; other site 762550003388 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 762550003389 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 762550003390 legume lectins; Region: lectin_L-type; cl14058 762550003391 homotetramer interaction site [polypeptide binding]; other site 762550003392 carbohydrate binding site [chemical binding]; other site 762550003393 metal binding site [ion binding]; metal-binding site 762550003394 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762550003395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550003396 MarR family; Region: MarR_2; pfam12802 762550003397 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 762550003398 hydrophobic ligand binding site; other site 762550003399 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 762550003400 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 762550003401 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 762550003402 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 762550003403 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 762550003404 active site 762550003405 phosphorylation site [posttranslational modification] 762550003406 PTS system fructose IIA component; Region: EIIA-man; pfam03610 762550003407 active pocket/dimerization site; other site 762550003408 active site 762550003409 phosphorylation site [posttranslational modification] 762550003410 DNA topoisomerase I; Validated; Region: PRK05582 762550003411 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 762550003412 active site 762550003413 interdomain interaction site; other site 762550003414 putative metal-binding site [ion binding]; other site 762550003415 nucleotide binding site [chemical binding]; other site 762550003416 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 762550003417 domain I; other site 762550003418 DNA binding groove [nucleotide binding] 762550003419 phosphate binding site [ion binding]; other site 762550003420 domain II; other site 762550003421 domain III; other site 762550003422 nucleotide binding site [chemical binding]; other site 762550003423 catalytic site [active] 762550003424 domain IV; other site 762550003425 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762550003426 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 762550003427 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 762550003428 DNA protecting protein DprA; Region: dprA; TIGR00732 762550003429 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 762550003430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550003431 Walker A/P-loop; other site 762550003432 ATP binding site [chemical binding]; other site 762550003433 Q-loop/lid; other site 762550003434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550003435 ABC transporter signature motif; other site 762550003436 Walker B; other site 762550003437 D-loop; other site 762550003438 ABC transporter; Region: ABC_tran_2; pfam12848 762550003439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 762550003440 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 762550003441 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 762550003442 active site 762550003443 FMN binding site [chemical binding]; other site 762550003444 substrate binding site [chemical binding]; other site 762550003445 catalytic residues [active] 762550003446 homodimer interface [polypeptide binding]; other site 762550003447 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762550003448 propionate/acetate kinase; Provisional; Region: PRK12379 762550003449 Bacterial SH3 domain; Region: SH3_3; pfam08239 762550003450 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 762550003451 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 762550003452 active site 762550003453 metal binding site [ion binding]; metal-binding site 762550003454 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 762550003455 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 762550003456 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 762550003457 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 762550003458 dimer interface [polypeptide binding]; other site 762550003459 active site 762550003460 glycine-pyridoxal phosphate binding site [chemical binding]; other site 762550003461 folate binding site [chemical binding]; other site 762550003462 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 762550003463 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 762550003464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550003465 catalytic residue [active] 762550003466 homoserine dehydrogenase; Provisional; Region: PRK06349 762550003467 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 762550003468 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 762550003469 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762550003470 homoserine kinase; Provisional; Region: PRK01212 762550003471 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550003472 aspartate kinase; Reviewed; Region: PRK09034 762550003473 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 762550003474 putative catalytic residues [active] 762550003475 putative nucleotide binding site [chemical binding]; other site 762550003476 putative aspartate binding site [chemical binding]; other site 762550003477 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 762550003478 allosteric regulatory residue; other site 762550003479 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 762550003480 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 762550003481 active site 762550003482 homotetramer interface [polypeptide binding]; other site 762550003483 homodimer interface [polypeptide binding]; other site 762550003484 Recombination protein O N terminal; Region: RecO_N; pfam11967 762550003485 DNA repair protein RecO; Region: reco; TIGR00613 762550003486 Recombination protein O C terminal; Region: RecO_C; pfam02565 762550003487 GTPase Era; Reviewed; Region: era; PRK00089 762550003488 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 762550003489 G1 box; other site 762550003490 GTP/Mg2+ binding site [chemical binding]; other site 762550003491 Switch I region; other site 762550003492 G2 box; other site 762550003493 Switch II region; other site 762550003494 G3 box; other site 762550003495 G4 box; other site 762550003496 G5 box; other site 762550003497 KH domain; Region: KH_2; pfam07650 762550003498 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 762550003499 metal-binding heat shock protein; Provisional; Region: PRK00016 762550003500 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 762550003501 PhoH-like protein; Region: PhoH; pfam02562 762550003502 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 762550003503 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 762550003504 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 762550003505 domain interfaces; other site 762550003506 active site 762550003507 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 762550003508 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 762550003509 active site 762550003510 PHP Thumb interface [polypeptide binding]; other site 762550003511 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 762550003512 generic binding surface II; other site 762550003513 generic binding surface I; other site 762550003514 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 762550003515 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 762550003516 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 762550003517 active site 762550003518 catalytic residue [active] 762550003519 dimer interface [polypeptide binding]; other site 762550003520 Prephenate dehydratase; Region: PDT; pfam00800 762550003521 shikimate kinase; Reviewed; Region: aroK; PRK00131 762550003522 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 762550003523 ADP binding site [chemical binding]; other site 762550003524 magnesium binding site [ion binding]; other site 762550003525 putative shikimate binding site; other site 762550003526 Chorismate mutase type II; Region: CM_2; smart00830 762550003527 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 762550003528 prephenate dehydrogenase; Validated; Region: PRK08507 762550003529 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 762550003530 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 762550003531 hinge; other site 762550003532 active site 762550003533 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 762550003534 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 762550003535 Tetramer interface [polypeptide binding]; other site 762550003536 active site 762550003537 FMN-binding site [chemical binding]; other site 762550003538 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 762550003539 active site 762550003540 dimer interface [polypeptide binding]; other site 762550003541 metal binding site [ion binding]; metal-binding site 762550003542 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 762550003543 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 762550003544 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 762550003545 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 762550003546 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 762550003547 shikimate binding site; other site 762550003548 NAD(P) binding site [chemical binding]; other site 762550003549 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 762550003550 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 762550003551 TPP-binding site [chemical binding]; other site 762550003552 dimer interface [polypeptide binding]; other site 762550003553 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 762550003554 PYR/PP interface [polypeptide binding]; other site 762550003555 dimer interface [polypeptide binding]; other site 762550003556 TPP binding site [chemical binding]; other site 762550003557 CsbD-like; Region: CsbD; pfam05532 762550003558 EDD domain protein, DegV family; Region: DegV; TIGR00762 762550003559 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 762550003560 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 762550003561 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 762550003562 folate binding site [chemical binding]; other site 762550003563 NADP+ binding site [chemical binding]; other site 762550003564 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 762550003565 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 762550003566 active site 762550003567 NTP binding site [chemical binding]; other site 762550003568 metal binding triad [ion binding]; metal-binding site 762550003569 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 762550003570 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 762550003571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762550003572 binding surface 762550003573 TPR motif; other site 762550003574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762550003575 TPR motif; other site 762550003576 binding surface 762550003577 TPR repeat; Region: TPR_11; pfam13414 762550003578 TPR repeat; Region: TPR_11; pfam13414 762550003579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 762550003580 TPR motif; other site 762550003581 binding surface 762550003582 CsbD-like; Region: CsbD; pfam05532 762550003583 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 762550003584 IHF dimer interface [polypeptide binding]; other site 762550003585 IHF - DNA interface [nucleotide binding]; other site 762550003586 GTP-binding protein Der; Reviewed; Region: PRK00093 762550003587 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 762550003588 G1 box; other site 762550003589 GTP/Mg2+ binding site [chemical binding]; other site 762550003590 Switch I region; other site 762550003591 G2 box; other site 762550003592 Switch II region; other site 762550003593 G3 box; other site 762550003594 G4 box; other site 762550003595 G5 box; other site 762550003596 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 762550003597 G1 box; other site 762550003598 GTP/Mg2+ binding site [chemical binding]; other site 762550003599 Switch I region; other site 762550003600 G2 box; other site 762550003601 G3 box; other site 762550003602 Switch II region; other site 762550003603 G4 box; other site 762550003604 G5 box; other site 762550003605 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 762550003606 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 762550003607 RNA binding site [nucleotide binding]; other site 762550003608 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 762550003609 RNA binding site [nucleotide binding]; other site 762550003610 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762550003611 RNA binding site [nucleotide binding]; other site 762550003612 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 762550003613 RNA binding site [nucleotide binding]; other site 762550003614 cytidylate kinase; Provisional; Region: cmk; PRK00023 762550003615 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 762550003616 CMP-binding site; other site 762550003617 The sites determining sugar specificity; other site 762550003618 Predicted membrane protein [Function unknown]; Region: COG3601 762550003619 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 762550003620 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 762550003621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550003622 RNA binding surface [nucleotide binding]; other site 762550003623 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 762550003624 active site 762550003625 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 762550003626 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 762550003627 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 762550003628 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 762550003629 active site 762550003630 Int/Topo IB signature motif; other site 762550003631 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 762550003632 S1 domain; Region: S1_2; pfam13509 762550003633 Yqey-like protein; Region: YqeY; pfam09424 762550003634 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 762550003635 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 762550003636 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 762550003637 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 762550003638 active site 762550003639 Zn binding site [ion binding]; other site 762550003640 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 762550003641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003642 putative substrate translocation pore; other site 762550003643 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 762550003644 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 762550003645 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762550003646 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 762550003647 Enterocin A Immunity; Region: EntA_Immun; pfam08951 762550003648 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 762550003649 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003650 Uncharacterized conserved protein [Function unknown]; Region: COG1284 762550003651 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 762550003652 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 762550003653 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 762550003654 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 762550003655 dimer interface [polypeptide binding]; other site 762550003656 anticodon binding site; other site 762550003657 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550003658 motif 1; other site 762550003659 dimer interface [polypeptide binding]; other site 762550003660 active site 762550003661 motif 2; other site 762550003662 GAD domain; Region: GAD; pfam02938 762550003663 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550003664 active site 762550003665 motif 3; other site 762550003666 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 762550003667 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 762550003668 dimer interface [polypeptide binding]; other site 762550003669 motif 1; other site 762550003670 active site 762550003671 motif 2; other site 762550003672 motif 3; other site 762550003673 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 762550003674 anticodon binding site; other site 762550003675 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003676 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762550003677 Ca binding site [ion binding]; other site 762550003678 active site 762550003679 catalytic site [active] 762550003680 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762550003681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003682 putative substrate translocation pore; other site 762550003683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550003684 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003685 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762550003686 Ca binding site [ion binding]; other site 762550003687 active site 762550003688 catalytic site [active] 762550003689 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762550003690 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003692 DNA binding site [nucleotide binding] 762550003693 domain linker motif; other site 762550003694 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550003695 dimerization interface [polypeptide binding]; other site 762550003696 ligand binding site [chemical binding]; other site 762550003697 beta-phosphoglucomutase; Region: bPGM; TIGR01990 762550003698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550003699 motif II; other site 762550003700 maltose phosphorylase; Provisional; Region: PRK13807 762550003701 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 762550003702 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 762550003703 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 762550003704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550003706 putative substrate translocation pore; other site 762550003707 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003708 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003709 DNA binding site [nucleotide binding] 762550003710 domain linker motif; other site 762550003711 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 762550003712 ligand binding site [chemical binding]; other site 762550003713 dimerization interface [polypeptide binding]; other site 762550003714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550003715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550003716 DNA binding site [nucleotide binding] 762550003717 domain linker motif; other site 762550003718 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550003719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 762550003720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550003721 dimer interface [polypeptide binding]; other site 762550003722 conserved gate region; other site 762550003723 putative PBP binding loops; other site 762550003724 ABC-ATPase subunit interface; other site 762550003725 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 762550003726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550003727 dimer interface [polypeptide binding]; other site 762550003728 conserved gate region; other site 762550003729 putative PBP binding loops; other site 762550003730 ABC-ATPase subunit interface; other site 762550003731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 762550003732 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 762550003733 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 762550003734 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 762550003735 Walker A/P-loop; other site 762550003736 ATP binding site [chemical binding]; other site 762550003737 Q-loop/lid; other site 762550003738 ABC transporter signature motif; other site 762550003739 Walker B; other site 762550003740 D-loop; other site 762550003741 H-loop/switch region; other site 762550003742 TOBE domain; Region: TOBE; pfam03459 762550003743 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 762550003744 homodimer interface [polypeptide binding]; other site 762550003745 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 762550003746 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 762550003747 active site 762550003748 homodimer interface [polypeptide binding]; other site 762550003749 catalytic site [active] 762550003750 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550003751 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762550003752 Ca binding site [ion binding]; other site 762550003753 active site 762550003754 catalytic site [active] 762550003755 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 762550003756 dimer interface [polypeptide binding]; other site 762550003757 FMN binding site [chemical binding]; other site 762550003758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550003759 Coenzyme A binding pocket [chemical binding]; other site 762550003760 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 762550003761 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 762550003762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 762550003763 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 762550003764 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 762550003765 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 762550003766 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 762550003767 putative dimer interface [polypeptide binding]; other site 762550003768 putative anticodon binding site; other site 762550003769 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 762550003770 homodimer interface [polypeptide binding]; other site 762550003771 motif 1; other site 762550003772 motif 2; other site 762550003773 active site 762550003774 motif 3; other site 762550003775 aspartate aminotransferase; Provisional; Region: PRK05764 762550003776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550003777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550003778 homodimer interface [polypeptide binding]; other site 762550003779 catalytic residue [active] 762550003780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 762550003781 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762550003782 active site 762550003783 catalytic site [active] 762550003784 substrate binding site [chemical binding]; other site 762550003785 mevalonate kinase; Region: mevalon_kin; TIGR00549 762550003786 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762550003787 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 762550003788 active site 762550003789 catalytic site [active] 762550003790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 762550003791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 762550003792 active site 762550003793 catalytic tetrad [active] 762550003794 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 762550003795 active site 762550003796 catalytic triad [active] 762550003797 oxyanion hole [active] 762550003798 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 762550003799 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 762550003800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550003801 active site 762550003802 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 762550003803 AAA domain; Region: AAA_30; pfam13604 762550003804 Family description; Region: UvrD_C_2; pfam13538 762550003805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550003806 catalytic core [active] 762550003807 Putative amino acid metabolism; Region: DUF1831; pfam08866 762550003808 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550003809 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762550003810 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 762550003811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550003812 S-adenosylmethionine binding site [chemical binding]; other site 762550003813 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 762550003814 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762550003815 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 762550003816 substrate binding site [chemical binding]; other site 762550003817 dimer interface [polypeptide binding]; other site 762550003818 ATP binding site [chemical binding]; other site 762550003819 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 762550003820 DNA polymerase III PolC; Validated; Region: polC; PRK00448 762550003821 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 762550003822 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 762550003823 generic binding surface II; other site 762550003824 generic binding surface I; other site 762550003825 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 762550003826 active site 762550003827 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 762550003828 active site 762550003829 catalytic site [active] 762550003830 substrate binding site [chemical binding]; other site 762550003831 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 762550003832 prolyl-tRNA synthetase; Provisional; Region: PRK09194 762550003833 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 762550003834 dimer interface [polypeptide binding]; other site 762550003835 motif 1; other site 762550003836 active site 762550003837 motif 2; other site 762550003838 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 762550003839 putative deacylase active site [active] 762550003840 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 762550003841 active site 762550003842 motif 3; other site 762550003843 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 762550003844 anticodon binding site; other site 762550003845 RIP metalloprotease RseP; Region: TIGR00054 762550003846 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762550003847 active site 762550003848 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 762550003849 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 762550003850 protein binding site [polypeptide binding]; other site 762550003851 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 762550003852 putative substrate binding region [chemical binding]; other site 762550003853 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 762550003854 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 762550003855 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 762550003856 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 762550003857 catalytic residue [active] 762550003858 putative FPP diphosphate binding site; other site 762550003859 putative FPP binding hydrophobic cleft; other site 762550003860 dimer interface [polypeptide binding]; other site 762550003861 putative IPP diphosphate binding site; other site 762550003862 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 762550003863 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 762550003864 glutaminase active site [active] 762550003865 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 762550003866 dimer interface [polypeptide binding]; other site 762550003867 active site 762550003868 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 762550003869 dimer interface [polypeptide binding]; other site 762550003870 active site 762550003871 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 762550003872 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 762550003873 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 762550003874 active site 762550003875 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 762550003876 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 762550003877 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 762550003878 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 762550003879 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 762550003880 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 762550003881 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 762550003882 Domain of unknown function DUF20; Region: UPF0118; pfam01594 762550003883 diphosphomevalonate decarboxylase; Region: PLN02407 762550003884 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 762550003885 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 762550003886 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 762550003887 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 762550003888 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 762550003889 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 762550003890 homotetramer interface [polypeptide binding]; other site 762550003891 FMN binding site [chemical binding]; other site 762550003892 homodimer contacts [polypeptide binding]; other site 762550003893 putative active site [active] 762550003894 putative substrate binding site [chemical binding]; other site 762550003895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550003896 active site 762550003897 adenylosuccinate lyase; Provisional; Region: PRK07492 762550003898 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 762550003899 tetramer interface [polypeptide binding]; other site 762550003900 active site 762550003901 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 762550003902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550003903 putative substrate translocation pore; other site 762550003904 Predicted esterase [General function prediction only]; Region: COG0627 762550003905 S-formylglutathione hydrolase; Region: PLN02442 762550003906 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 762550003907 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 762550003908 Potassium binding sites [ion binding]; other site 762550003909 Cesium cation binding sites [ion binding]; other site 762550003910 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 762550003911 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 762550003912 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 762550003913 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 762550003914 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 762550003915 putative active site [active] 762550003916 nucleotide binding site [chemical binding]; other site 762550003917 nudix motif; other site 762550003918 putative metal binding site [ion binding]; other site 762550003919 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 762550003920 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 762550003921 purine monophosphate binding site [chemical binding]; other site 762550003922 dimer interface [polypeptide binding]; other site 762550003923 putative catalytic residues [active] 762550003924 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 762550003925 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 762550003926 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 762550003927 active site 762550003928 substrate binding site [chemical binding]; other site 762550003929 cosubstrate binding site; other site 762550003930 catalytic site [active] 762550003931 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 762550003932 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 762550003933 dimerization interface [polypeptide binding]; other site 762550003934 putative ATP binding site [chemical binding]; other site 762550003935 amidophosphoribosyltransferase; Provisional; Region: PRK07272 762550003936 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 762550003937 active site 762550003938 tetramer interface [polypeptide binding]; other site 762550003939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550003940 active site 762550003941 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 762550003942 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 762550003943 dimerization interface [polypeptide binding]; other site 762550003944 ATP binding site [chemical binding]; other site 762550003945 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 762550003946 dimerization interface [polypeptide binding]; other site 762550003947 ATP binding site [chemical binding]; other site 762550003948 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 762550003949 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 762550003950 putative active site [active] 762550003951 catalytic triad [active] 762550003952 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 762550003953 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 762550003954 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 762550003955 ATP binding site [chemical binding]; other site 762550003956 active site 762550003957 substrate binding site [chemical binding]; other site 762550003958 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 762550003959 ATP-grasp domain; Region: ATP-grasp; pfam02222 762550003960 AIR carboxylase; Region: AIRC; pfam00731 762550003961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550003962 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550003963 substrate binding pocket [chemical binding]; other site 762550003964 membrane-bound complex binding site; other site 762550003965 hinge residues; other site 762550003966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550003967 dimer interface [polypeptide binding]; other site 762550003968 conserved gate region; other site 762550003969 ABC-ATPase subunit interface; other site 762550003970 cell division protein GpsB; Provisional; Region: PRK14127 762550003971 DivIVA domain; Region: DivI1A_domain; TIGR03544 762550003972 hypothetical protein; Provisional; Region: PRK13660 762550003973 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 762550003974 Transglycosylase; Region: Transgly; pfam00912 762550003975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 762550003976 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 762550003977 GMP synthase; Reviewed; Region: guaA; PRK00074 762550003978 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 762550003979 AMP/PPi binding site [chemical binding]; other site 762550003980 candidate oxyanion hole; other site 762550003981 catalytic triad [active] 762550003982 potential glutamine specificity residues [chemical binding]; other site 762550003983 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 762550003984 ATP Binding subdomain [chemical binding]; other site 762550003985 Dimerization subdomain; other site 762550003986 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762550003987 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 762550003988 phosphate binding site [ion binding]; other site 762550003989 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 762550003990 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 762550003991 active site 762550003992 heat shock protein HtpX; Provisional; Region: PRK04897 762550003993 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 762550003994 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 762550003995 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 762550003996 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 762550003997 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762550003998 HIGH motif; other site 762550003999 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762550004000 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 762550004001 active site 762550004002 KMSKS motif; other site 762550004003 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 762550004004 tRNA binding surface [nucleotide binding]; other site 762550004005 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762550004006 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762550004007 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762550004008 active site 762550004009 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 762550004010 active site 762550004011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550004012 Ligand Binding Site [chemical binding]; other site 762550004013 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 762550004014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550004015 active site 762550004016 dimer interface [polypeptide binding]; other site 762550004017 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550004018 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762550004019 Walker A/P-loop; other site 762550004020 ATP binding site [chemical binding]; other site 762550004021 Q-loop/lid; other site 762550004022 ABC transporter signature motif; other site 762550004023 Walker B; other site 762550004024 D-loop; other site 762550004025 H-loop/switch region; other site 762550004026 elongation factor Tu; Reviewed; Region: PRK00049 762550004027 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 762550004028 G1 box; other site 762550004029 GEF interaction site [polypeptide binding]; other site 762550004030 GTP/Mg2+ binding site [chemical binding]; other site 762550004031 Switch I region; other site 762550004032 G2 box; other site 762550004033 G3 box; other site 762550004034 Switch II region; other site 762550004035 G4 box; other site 762550004036 G5 box; other site 762550004037 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 762550004038 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 762550004039 Antibiotic Binding Site [chemical binding]; other site 762550004040 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 762550004041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 762550004042 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 762550004043 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 762550004044 23S rRNA binding site [nucleotide binding]; other site 762550004045 L21 binding site [polypeptide binding]; other site 762550004046 L13 binding site [polypeptide binding]; other site 762550004047 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 762550004048 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 762550004049 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 762550004050 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 762550004051 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 762550004052 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762550004053 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 762550004054 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 762550004055 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762550004056 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 762550004057 active site 762550004058 dimer interface [polypeptide binding]; other site 762550004059 motif 1; other site 762550004060 motif 2; other site 762550004061 motif 3; other site 762550004062 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 762550004063 anticodon binding site; other site 762550004064 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 762550004065 amphipathic channel; other site 762550004066 Asn-Pro-Ala signature motifs; other site 762550004067 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 762550004068 hypothetical protein; Validated; Region: PRK00110 762550004069 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 762550004070 tetramer interfaces [polypeptide binding]; other site 762550004071 binuclear metal-binding site [ion binding]; other site 762550004072 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 762550004073 putative ligand binding site [chemical binding]; other site 762550004074 putative NAD binding site [chemical binding]; other site 762550004075 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550004076 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 762550004077 L-serine binding site [chemical binding]; other site 762550004078 ACT domain interface; other site 762550004079 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 762550004080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550004081 catalytic residue [active] 762550004082 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550004083 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550004084 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 762550004085 Walker A/P-loop; other site 762550004086 ATP binding site [chemical binding]; other site 762550004087 Q-loop/lid; other site 762550004088 ABC transporter signature motif; other site 762550004089 Walker B; other site 762550004090 D-loop; other site 762550004091 H-loop/switch region; other site 762550004092 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 762550004093 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 762550004094 ligand binding site [chemical binding]; other site 762550004095 active site 762550004096 UGI interface [polypeptide binding]; other site 762550004097 catalytic site [active] 762550004098 Tubby C 2; Region: Tub_2; cl02043 762550004099 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 762550004100 FAD binding site [chemical binding]; other site 762550004101 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 762550004102 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 762550004103 S-methylmethionine transporter; Provisional; Region: PRK11387 762550004104 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762550004105 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762550004106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550004107 active site 762550004108 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 762550004109 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 762550004110 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550004111 active site 762550004112 HIGH motif; other site 762550004113 nucleotide binding site [chemical binding]; other site 762550004114 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 762550004115 active site 762550004116 KMSKS motif; other site 762550004117 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 762550004118 tRNA binding surface [nucleotide binding]; other site 762550004119 anticodon binding site; other site 762550004120 DivIVA protein; Region: DivIVA; pfam05103 762550004121 DivIVA domain; Region: DivI1A_domain; TIGR03544 762550004122 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 762550004123 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550004124 RNA binding surface [nucleotide binding]; other site 762550004125 YGGT family; Region: YGGT; pfam02325 762550004126 Protein of unknown function (DUF552); Region: DUF552; pfam04472 762550004127 cell division protein FtsZ; Validated; Region: PRK09330 762550004128 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 762550004129 nucleotide binding site [chemical binding]; other site 762550004130 SulA interaction site; other site 762550004131 cell division protein FtsA; Region: ftsA; TIGR01174 762550004132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762550004133 nucleotide binding site [chemical binding]; other site 762550004134 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 762550004135 Cell division protein FtsA; Region: FtsA; pfam14450 762550004136 Cell division protein FtsQ; Region: FtsQ; pfam03799 762550004137 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 762550004138 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 762550004139 active site 762550004140 homodimer interface [polypeptide binding]; other site 762550004141 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 762550004142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550004143 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 762550004144 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 762550004145 Mg++ binding site [ion binding]; other site 762550004146 putative catalytic motif [active] 762550004147 putative substrate binding site [chemical binding]; other site 762550004148 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762550004149 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762550004150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762550004151 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 762550004152 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 762550004153 Cell division protein FtsL; Region: FtsL; cl11433 762550004154 MraW methylase family; Region: Methyltransf_5; pfam01795 762550004155 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 762550004156 cell division protein MraZ; Reviewed; Region: PRK00326 762550004157 MraZ protein; Region: MraZ; pfam02381 762550004158 MraZ protein; Region: MraZ; pfam02381 762550004159 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 762550004160 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 762550004161 DAK2 domain; Region: Dak2; pfam02734 762550004162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 762550004163 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 762550004164 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 762550004165 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 762550004166 catalytic residues [active] 762550004167 Thiamine pyrophosphokinase; Region: TPK; cd07995 762550004168 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 762550004169 active site 762550004170 dimerization interface [polypeptide binding]; other site 762550004171 thiamine binding site [chemical binding]; other site 762550004172 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 762550004173 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 762550004174 substrate binding site [chemical binding]; other site 762550004175 hexamer interface [polypeptide binding]; other site 762550004176 metal binding site [ion binding]; metal-binding site 762550004177 GTPase RsgA; Reviewed; Region: PRK00098 762550004178 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 762550004179 RNA binding site [nucleotide binding]; other site 762550004180 homodimer interface [polypeptide binding]; other site 762550004181 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 762550004182 GTPase/Zn-binding domain interface [polypeptide binding]; other site 762550004183 GTP/Mg2+ binding site [chemical binding]; other site 762550004184 G4 box; other site 762550004185 G5 box; other site 762550004186 G1 box; other site 762550004187 Switch I region; other site 762550004188 G2 box; other site 762550004189 G3 box; other site 762550004190 Switch II region; other site 762550004191 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 762550004192 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 762550004193 active site 762550004194 ATP binding site [chemical binding]; other site 762550004195 substrate binding site [chemical binding]; other site 762550004196 activation loop (A-loop); other site 762550004197 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762550004198 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762550004199 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 762550004200 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 762550004201 active site 762550004202 16S rRNA methyltransferase B; Provisional; Region: PRK14902 762550004203 NusB family; Region: NusB; pfam01029 762550004204 putative RNA binding site [nucleotide binding]; other site 762550004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550004206 S-adenosylmethionine binding site [chemical binding]; other site 762550004207 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 762550004208 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 762550004209 putative active site [active] 762550004210 substrate binding site [chemical binding]; other site 762550004211 putative cosubstrate binding site; other site 762550004212 catalytic site [active] 762550004213 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 762550004214 substrate binding site [chemical binding]; other site 762550004215 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 762550004216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550004217 ATP binding site [chemical binding]; other site 762550004218 putative Mg++ binding site [ion binding]; other site 762550004219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004220 ATP-binding site [chemical binding]; other site 762550004221 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 762550004222 G1 box; other site 762550004223 GTP/Mg2+ binding site [chemical binding]; other site 762550004224 Switch I region; other site 762550004225 G2 box; other site 762550004226 G3 box; other site 762550004227 Switch II region; other site 762550004228 G4 box; other site 762550004229 G5 box; other site 762550004230 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 762550004231 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 762550004232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550004233 Walker A motif; other site 762550004234 ATP binding site [chemical binding]; other site 762550004235 Walker B motif; other site 762550004236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 762550004237 trigger factor; Provisional; Region: tig; PRK01490 762550004238 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 762550004239 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 762550004240 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550004241 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 762550004242 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 762550004243 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 762550004244 acetoin reductases; Region: 23BDH; TIGR02415 762550004245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004246 NAD(P) binding site [chemical binding]; other site 762550004247 active site 762550004248 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 762550004249 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550004250 active site 762550004251 nucleotide binding site [chemical binding]; other site 762550004252 HIGH motif; other site 762550004253 KMSKS motif; other site 762550004254 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 762550004255 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 762550004256 methionine sulfoxide reductase B; Provisional; Region: PRK00222 762550004257 SelR domain; Region: SelR; pfam01641 762550004258 dipeptidase PepV; Reviewed; Region: PRK07318 762550004259 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 762550004260 active site 762550004261 metal binding site [ion binding]; metal-binding site 762550004262 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 762550004263 putative substrate binding site [chemical binding]; other site 762550004264 putative ATP binding site [chemical binding]; other site 762550004265 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 762550004266 active site 762550004267 putative catalytic site [active] 762550004268 DNA binding site [nucleotide binding] 762550004269 putative phosphate binding site [ion binding]; other site 762550004270 metal binding site A [ion binding]; metal-binding site 762550004271 AP binding site [nucleotide binding]; other site 762550004272 metal binding site B [ion binding]; metal-binding site 762550004273 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 762550004274 active site 762550004275 catalytic site [active] 762550004276 substrate binding site [chemical binding]; other site 762550004277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 762550004278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550004279 Coenzyme A binding pocket [chemical binding]; other site 762550004280 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 762550004281 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 762550004282 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 762550004283 active site 762550004284 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 762550004285 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 762550004286 homodimer interface [polypeptide binding]; other site 762550004287 NAD binding pocket [chemical binding]; other site 762550004288 ATP binding pocket [chemical binding]; other site 762550004289 Mg binding site [ion binding]; other site 762550004290 active-site loop [active] 762550004291 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 762550004292 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 762550004293 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 762550004294 protein binding site [polypeptide binding]; other site 762550004295 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 762550004296 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 762550004297 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 762550004298 active site 762550004299 (T/H)XGH motif; other site 762550004300 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 762550004301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550004302 S-adenosylmethionine binding site [chemical binding]; other site 762550004303 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 762550004304 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 762550004305 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 762550004306 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 762550004307 oligomer interface [polypeptide binding]; other site 762550004308 active site 762550004309 metal binding site [ion binding]; metal-binding site 762550004310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004311 catalytic core [active] 762550004312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004313 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 762550004314 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 762550004315 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762550004316 Walker A/P-loop; other site 762550004317 ATP binding site [chemical binding]; other site 762550004318 Q-loop/lid; other site 762550004319 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 762550004320 ABC transporter signature motif; other site 762550004321 Walker B; other site 762550004322 D-loop; other site 762550004323 H-loop/switch region; other site 762550004324 Arginine repressor [Transcription]; Region: ArgR; COG1438 762550004325 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 762550004326 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 762550004327 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 762550004328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 762550004329 RNA binding surface [nucleotide binding]; other site 762550004330 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 762550004331 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762550004332 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762550004333 substrate binding pocket [chemical binding]; other site 762550004334 chain length determination region; other site 762550004335 catalytic residues [active] 762550004336 aspartate-rich region 1; other site 762550004337 substrate-Mg2+ binding site; other site 762550004338 active site lid residues [active] 762550004339 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 762550004340 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 762550004341 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 762550004342 generic binding surface II; other site 762550004343 generic binding surface I; other site 762550004344 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 762550004345 putative dimer interface [polypeptide binding]; other site 762550004346 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 762550004347 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 762550004348 putative dimer interface [polypeptide binding]; other site 762550004349 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 762550004350 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 762550004351 nucleotide binding pocket [chemical binding]; other site 762550004352 K-X-D-G motif; other site 762550004353 catalytic site [active] 762550004354 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 762550004355 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 762550004356 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 762550004357 Dimer interface [polypeptide binding]; other site 762550004358 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 762550004359 Part of AAA domain; Region: AAA_19; pfam13245 762550004360 Family description; Region: UvrD_C_2; pfam13538 762550004361 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 762550004362 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 762550004363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550004364 Walker A/P-loop; other site 762550004365 ATP binding site [chemical binding]; other site 762550004366 Q-loop/lid; other site 762550004367 ABC transporter signature motif; other site 762550004368 Walker B; other site 762550004369 D-loop; other site 762550004370 H-loop/switch region; other site 762550004371 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 762550004372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550004373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550004374 Walker A/P-loop; other site 762550004375 ATP binding site [chemical binding]; other site 762550004376 Q-loop/lid; other site 762550004377 ABC transporter signature motif; other site 762550004378 Walker B; other site 762550004379 D-loop; other site 762550004380 H-loop/switch region; other site 762550004381 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 762550004382 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 762550004383 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 762550004384 hypothetical protein; Provisional; Region: PRK13678 762550004385 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 762550004386 hypothetical protein; Provisional; Region: PRK05473 762550004387 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 762550004388 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 762550004389 motif 1; other site 762550004390 active site 762550004391 motif 2; other site 762550004392 motif 3; other site 762550004393 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 762550004394 DHHA1 domain; Region: DHHA1; pfam02272 762550004395 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 762550004396 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762550004397 inhibitor-cofactor binding pocket; inhibition site 762550004398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550004399 catalytic residue [active] 762550004400 amino acid transporter; Region: 2A0306; TIGR00909 762550004401 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 762550004402 GntP family permease; Region: GntP_permease; pfam02447 762550004403 fructuronate transporter; Provisional; Region: PRK10034; cl15264 762550004404 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 762550004405 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 762550004406 N- and C-terminal domain interface [polypeptide binding]; other site 762550004407 active site 762550004408 catalytic site [active] 762550004409 metal binding site [ion binding]; metal-binding site 762550004410 carbohydrate binding site [chemical binding]; other site 762550004411 ATP binding site [chemical binding]; other site 762550004412 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 762550004413 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 762550004414 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 762550004415 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 762550004416 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 762550004417 putative active site [active] 762550004418 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 762550004419 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 762550004420 Sugar specificity; other site 762550004421 Pyrimidine base specificity; other site 762550004422 ATP-binding site [chemical binding]; other site 762550004423 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 762550004424 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762550004425 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 762550004426 catalytic triad [active] 762550004427 catalytic triad [active] 762550004428 oxyanion hole [active] 762550004429 catabolite control protein A; Region: ccpA; TIGR01481 762550004430 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004431 DNA binding site [nucleotide binding] 762550004432 domain linker motif; other site 762550004433 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 762550004434 dimerization interface [polypeptide binding]; other site 762550004435 effector binding site; other site 762550004436 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 762550004437 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 762550004438 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 762550004439 active site 762550004440 CAAX protease self-immunity; Region: Abi; pfam02517 762550004441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550004442 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550004443 active site 762550004444 motif I; other site 762550004445 motif II; other site 762550004446 hypothetical protein; Provisional; Region: PRK04351 762550004447 SprT homologues; Region: SprT; cl01182 762550004448 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 762550004449 acyl carrier protein; Provisional; Region: acpP; PRK00982 762550004450 putative phosphate acyltransferase; Provisional; Region: PRK05331 762550004451 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 762550004452 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 762550004453 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 762550004454 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 762550004455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004456 Zn2+ binding site [ion binding]; other site 762550004457 Mg2+ binding site [ion binding]; other site 762550004458 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 762550004459 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 762550004460 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 762550004461 benzoate transport; Region: 2A0115; TIGR00895 762550004462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004463 putative substrate translocation pore; other site 762550004464 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 762550004465 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 762550004466 Zn binding site [ion binding]; other site 762550004467 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550004468 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762550004469 putative ligand binding site [chemical binding]; other site 762550004470 putative NAD binding site [chemical binding]; other site 762550004471 catalytic site [active] 762550004472 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 762550004473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 762550004474 substrate binding site [chemical binding]; other site 762550004475 ATP binding site [chemical binding]; other site 762550004476 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 762550004477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004479 DNA binding site [nucleotide binding] 762550004480 domain linker motif; other site 762550004481 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 762550004482 putative dimerization interface [polypeptide binding]; other site 762550004483 putative ligand binding site [chemical binding]; other site 762550004484 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 762550004485 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 762550004486 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 762550004487 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762550004488 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550004489 active site 762550004490 catalytic site [active] 762550004491 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 762550004492 peroxiredoxin; Region: AhpC; TIGR03137 762550004493 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 762550004494 dimer interface [polypeptide binding]; other site 762550004495 decamer (pentamer of dimers) interface [polypeptide binding]; other site 762550004496 catalytic triad [active] 762550004497 peroxidatic and resolving cysteines [active] 762550004498 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 762550004499 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 762550004500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550004501 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 762550004502 catalytic residue [active] 762550004503 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 762550004504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 762550004505 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 762550004506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 762550004507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550004508 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550004509 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 762550004510 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 762550004511 E3 interaction surface; other site 762550004512 lipoyl attachment site [posttranslational modification]; other site 762550004513 e3 binding domain; Region: E3_binding; pfam02817 762550004514 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 762550004515 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 762550004516 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 762550004517 alpha subunit interface [polypeptide binding]; other site 762550004518 TPP binding site [chemical binding]; other site 762550004519 heterodimer interface [polypeptide binding]; other site 762550004520 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 762550004521 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 762550004522 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 762550004523 tetramer interface [polypeptide binding]; other site 762550004524 TPP-binding site [chemical binding]; other site 762550004525 heterodimer interface [polypeptide binding]; other site 762550004526 phosphorylation loop region [posttranslational modification] 762550004527 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 762550004528 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 762550004529 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 762550004530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 762550004531 active site residue [active] 762550004532 adaptor protein; Provisional; Region: PRK02315 762550004533 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 762550004534 ArsC family; Region: ArsC; pfam03960 762550004535 putative catalytic residues [active] 762550004536 thiol/disulfide switch; other site 762550004537 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 762550004538 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 762550004539 RNA binding site [nucleotide binding]; other site 762550004540 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 762550004541 active site 762550004542 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 762550004543 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 762550004544 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 762550004545 catalytic site [active] 762550004546 G-X2-G-X-G-K; other site 762550004547 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 762550004548 phosphodiesterase; Provisional; Region: PRK12704 762550004549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004550 Zn2+ binding site [ion binding]; other site 762550004551 Mg2+ binding site [ion binding]; other site 762550004552 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 762550004553 SmpB-tmRNA interface; other site 762550004554 ribonuclease R; Region: RNase_R; TIGR02063 762550004555 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 762550004556 RNB domain; Region: RNB; pfam00773 762550004557 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 762550004558 RNA binding site [nucleotide binding]; other site 762550004559 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 762550004560 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 762550004561 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 762550004562 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762550004563 OxaA-like protein precursor; Provisional; Region: PRK02463 762550004564 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762550004565 Acylphosphatase; Region: Acylphosphatase; pfam00708 762550004566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550004567 HAMP domain; Region: HAMP; pfam00672 762550004568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762550004569 dimer interface [polypeptide binding]; other site 762550004570 phosphorylation site [posttranslational modification] 762550004571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550004572 ATP binding site [chemical binding]; other site 762550004573 Mg2+ binding site [ion binding]; other site 762550004574 G-X-G motif; other site 762550004575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550004576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550004577 active site 762550004578 phosphorylation site [posttranslational modification] 762550004579 intermolecular recognition site; other site 762550004580 dimerization interface [polypeptide binding]; other site 762550004581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550004582 DNA binding site [nucleotide binding] 762550004583 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 762550004584 hypothetical protein; Provisional; Region: PRK13670 762550004585 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 762550004586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550004587 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 762550004588 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004589 Zn2+ binding site [ion binding]; other site 762550004590 Mg2+ binding site [ion binding]; other site 762550004591 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 762550004592 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 762550004593 active site 762550004594 (T/H)XGH motif; other site 762550004595 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 762550004596 GTPase YqeH; Provisional; Region: PRK13796 762550004597 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 762550004598 GTP/Mg2+ binding site [chemical binding]; other site 762550004599 G4 box; other site 762550004600 G5 box; other site 762550004601 G1 box; other site 762550004602 Switch I region; other site 762550004603 G2 box; other site 762550004604 G3 box; other site 762550004605 Switch II region; other site 762550004606 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 762550004607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550004608 active site 762550004609 motif I; other site 762550004610 motif II; other site 762550004611 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762550004612 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762550004613 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 762550004614 D-lactate dehydrogenase; Validated; Region: PRK08605 762550004615 homodimer interface [polypeptide binding]; other site 762550004616 ligand binding site [chemical binding]; other site 762550004617 NAD binding site [chemical binding]; other site 762550004618 catalytic site [active] 762550004619 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 762550004620 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 762550004621 oligomer interface [polypeptide binding]; other site 762550004622 active site residues [active] 762550004623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 762550004624 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 762550004625 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 762550004626 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 762550004627 phosphate binding site [ion binding]; other site 762550004628 putative substrate binding pocket [chemical binding]; other site 762550004629 dimer interface [polypeptide binding]; other site 762550004630 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 762550004631 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762550004632 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 762550004633 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 762550004634 excinuclease ABC subunit B; Provisional; Region: PRK05298 762550004635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550004636 ATP binding site [chemical binding]; other site 762550004637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004638 nucleotide binding region [chemical binding]; other site 762550004639 ATP-binding site [chemical binding]; other site 762550004640 Ultra-violet resistance protein B; Region: UvrB; pfam12344 762550004641 UvrB/uvrC motif; Region: UVR; pfam02151 762550004642 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762550004643 Sulfatase; Region: Sulfatase; pfam00884 762550004644 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 762550004645 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 762550004646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550004647 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 762550004648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550004649 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 762550004650 putative ADP-binding pocket [chemical binding]; other site 762550004651 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550004652 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550004653 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 762550004654 Walker A/P-loop; other site 762550004655 ATP binding site [chemical binding]; other site 762550004656 Q-loop/lid; other site 762550004657 ABC transporter signature motif; other site 762550004658 Walker B; other site 762550004659 D-loop; other site 762550004660 H-loop/switch region; other site 762550004661 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 762550004662 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 762550004663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550004664 Walker A/P-loop; other site 762550004665 ATP binding site [chemical binding]; other site 762550004666 Q-loop/lid; other site 762550004667 ABC transporter signature motif; other site 762550004668 Walker B; other site 762550004669 D-loop; other site 762550004670 H-loop/switch region; other site 762550004671 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 762550004672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550004673 Walker A/P-loop; other site 762550004674 ATP binding site [chemical binding]; other site 762550004675 Q-loop/lid; other site 762550004676 ABC transporter signature motif; other site 762550004677 Walker B; other site 762550004678 D-loop; other site 762550004679 H-loop/switch region; other site 762550004680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 762550004681 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 762550004682 FtsX-like permease family; Region: FtsX; pfam02687 762550004683 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 762550004684 nudix motif; other site 762550004685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004686 Zn2+ binding site [ion binding]; other site 762550004687 Mg2+ binding site [ion binding]; other site 762550004688 Predicted integral membrane protein [Function unknown]; Region: COG0392 762550004689 Uncharacterized conserved protein [Function unknown]; Region: COG2898 762550004690 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 762550004691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 762550004692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 762550004693 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 762550004694 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 762550004695 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 762550004696 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 762550004697 MPN+ (JAMM) motif; other site 762550004698 Zinc-binding site [ion binding]; other site 762550004699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550004700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550004701 putative substrate translocation pore; other site 762550004702 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 762550004703 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550004704 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 762550004705 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 762550004706 ATP binding site [chemical binding]; other site 762550004707 Mg++ binding site [ion binding]; other site 762550004708 motif III; other site 762550004709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550004710 nucleotide binding region [chemical binding]; other site 762550004711 ATP-binding site [chemical binding]; other site 762550004712 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 762550004713 Beta-lactamase; Region: Beta-lactamase; pfam00144 762550004714 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 762550004715 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 762550004716 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 762550004717 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 762550004718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550004719 S-adenosylmethionine binding site [chemical binding]; other site 762550004720 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 762550004721 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 762550004722 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 762550004723 hinge; other site 762550004724 active site 762550004725 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 762550004726 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 762550004727 putative tRNA-binding site [nucleotide binding]; other site 762550004728 B3/4 domain; Region: B3_4; pfam03483 762550004729 tRNA synthetase B5 domain; Region: B5; smart00874 762550004730 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 762550004731 dimer interface [polypeptide binding]; other site 762550004732 motif 1; other site 762550004733 motif 3; other site 762550004734 motif 2; other site 762550004735 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 762550004736 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 762550004737 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 762550004738 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 762550004739 dimer interface [polypeptide binding]; other site 762550004740 motif 1; other site 762550004741 active site 762550004742 motif 2; other site 762550004743 motif 3; other site 762550004744 Predicted transcriptional regulators [Transcription]; Region: COG1733 762550004745 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762550004746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 762550004747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 762550004748 nucleotide binding site [chemical binding]; other site 762550004749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 762550004750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 762550004751 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 762550004752 active site 762550004753 metal binding site [ion binding]; metal-binding site 762550004754 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 762550004755 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 762550004756 putative NAD(P) binding site [chemical binding]; other site 762550004757 catalytic Zn binding site [ion binding]; other site 762550004758 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004759 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004760 DNA binding site [nucleotide binding] 762550004761 domain linker motif; other site 762550004762 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550004763 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 762550004764 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 762550004765 putative ligand binding site [chemical binding]; other site 762550004766 putative NAD binding site [chemical binding]; other site 762550004767 catalytic site [active] 762550004768 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 762550004769 active site 762550004770 catalytic motif [active] 762550004771 Zn binding site [ion binding]; other site 762550004772 oligoendopeptidase F; Region: pepF; TIGR00181 762550004773 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 762550004774 active site 762550004775 Zn binding site [ion binding]; other site 762550004776 Competence protein CoiA-like family; Region: CoiA; cl11541 762550004777 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550004778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550004779 substrate binding pocket [chemical binding]; other site 762550004780 membrane-bound complex binding site; other site 762550004781 hinge residues; other site 762550004782 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550004783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550004784 dimer interface [polypeptide binding]; other site 762550004785 conserved gate region; other site 762550004786 putative PBP binding loops; other site 762550004787 ABC-ATPase subunit interface; other site 762550004788 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 762550004789 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 762550004790 Walker A/P-loop; other site 762550004791 ATP binding site [chemical binding]; other site 762550004792 Q-loop/lid; other site 762550004793 ABC transporter signature motif; other site 762550004794 Walker B; other site 762550004795 D-loop; other site 762550004796 H-loop/switch region; other site 762550004797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 762550004798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 762550004799 substrate binding pocket [chemical binding]; other site 762550004800 membrane-bound complex binding site; other site 762550004801 hinge residues; other site 762550004802 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 762550004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550004804 dimer interface [polypeptide binding]; other site 762550004805 conserved gate region; other site 762550004806 putative PBP binding loops; other site 762550004807 ABC-ATPase subunit interface; other site 762550004808 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 762550004809 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 762550004810 ligand binding site [chemical binding]; other site 762550004811 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 762550004812 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 762550004813 YibE/F-like protein; Region: YibE_F; pfam07907 762550004814 YibE/F-like protein; Region: YibE_F; pfam07907 762550004815 primosomal protein DnaI; Reviewed; Region: PRK08939 762550004816 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 762550004817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 762550004818 Walker A motif; other site 762550004819 ATP binding site [chemical binding]; other site 762550004820 Walker B motif; other site 762550004821 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 762550004822 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 762550004823 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 762550004824 CoA-binding site [chemical binding]; other site 762550004825 Protein of unknown function (DUF975); Region: DUF975; cl10504 762550004826 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 762550004827 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 762550004828 DNA binding site [nucleotide binding] 762550004829 catalytic residue [active] 762550004830 H2TH interface [polypeptide binding]; other site 762550004831 putative catalytic residues [active] 762550004832 turnover-facilitating residue; other site 762550004833 intercalation triad [nucleotide binding]; other site 762550004834 8OG recognition residue [nucleotide binding]; other site 762550004835 putative reading head residues; other site 762550004836 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 762550004837 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 762550004838 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 762550004839 MutS domain III; Region: MutS_III; pfam05192 762550004840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550004841 Walker A/P-loop; other site 762550004842 ATP binding site [chemical binding]; other site 762550004843 Q-loop/lid; other site 762550004844 ABC transporter signature motif; other site 762550004845 Walker B; other site 762550004846 D-loop; other site 762550004847 H-loop/switch region; other site 762550004848 N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275 762550004849 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 762550004850 Smr domain; Region: Smr; pfam01713 762550004851 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 762550004852 Colicin V production protein; Region: Colicin_V; pfam02674 762550004853 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 762550004854 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 762550004855 Phage capsid family; Region: Phage_capsid; pfam05065 762550004856 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 762550004857 Phage-related protein [Function unknown]; Region: COG4695; cl01923 762550004858 potential frameshift: common BLAST hit: gi|15672451|ref|NP_266625.1| terminase large subunit 762550004859 Phage Terminase; Region: Terminase_1; pfam03354 762550004860 potential frameshift: common BLAST hit: gi|15672451|ref|NP_266625.1| terminase large subunit 762550004861 Phage Terminase; Region: Terminase_1; pfam03354 762550004862 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 762550004863 Phage terminase, small subunit; Region: Terminase_4; pfam05119 762550004864 HTH-like domain; Region: HTH_21; pfam13276 762550004865 Integrase core domain; Region: rve; pfam00665 762550004866 Transposase; Region: HTH_Tnp_1; cl17663 762550004867 ribonuclease HIII; Provisional; Region: PRK00996 762550004868 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 762550004869 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 762550004870 RNA/DNA hybrid binding site [nucleotide binding]; other site 762550004871 active site 762550004872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550004873 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762550004874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762550004875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550004876 Coenzyme A binding pocket [chemical binding]; other site 762550004877 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 762550004878 DsrE/DsrF-like family; Region: DrsE; cl00672 762550004879 Virulence-associated protein E; Region: VirE; pfam05272 762550004880 potential frameshift: common BLAST hit: gi|296110912|ref|YP_003621293.1| prophage Lp4 protein 7, DNA replication 762550004881 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 762550004882 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 762550004883 polymerase nucleotide-binding site; other site 762550004884 DNA-binding residues [nucleotide binding]; DNA binding site 762550004885 nucleotide binding site [chemical binding]; other site 762550004886 primase nucleotide-binding site [nucleotide binding]; other site 762550004887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762550004888 sequence-specific DNA binding site [nucleotide binding]; other site 762550004889 salt bridge; other site 762550004890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550004891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550004892 sequence-specific DNA binding site [nucleotide binding]; other site 762550004893 salt bridge; other site 762550004894 Fic/DOC family; Region: Fic; cl00960 762550004895 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 762550004896 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 762550004897 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 762550004898 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 762550004899 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 762550004900 ATP-grasp domain; Region: ATP-grasp_4; cl17255 762550004901 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 762550004902 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762550004903 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 762550004904 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 762550004905 carboxyltransferase (CT) interaction site; other site 762550004906 biotinylation site [posttranslational modification]; other site 762550004907 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 762550004908 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 762550004909 dimer interface [polypeptide binding]; other site 762550004910 active site 762550004911 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 762550004912 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 762550004913 NAD(P) binding site [chemical binding]; other site 762550004914 homotetramer interface [polypeptide binding]; other site 762550004915 homodimer interface [polypeptide binding]; other site 762550004916 active site 762550004917 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 762550004918 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762550004919 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 762550004920 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 762550004921 FMN binding site [chemical binding]; other site 762550004922 substrate binding site [chemical binding]; other site 762550004923 putative catalytic residue [active] 762550004924 acyl carrier protein; Provisional; Region: acpP; PRK00982 762550004925 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762550004926 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762550004927 dimer interface [polypeptide binding]; other site 762550004928 active site 762550004929 CoA binding pocket [chemical binding]; other site 762550004930 MarR family; Region: MarR_2; pfam12802 762550004931 Transcriptional regulators [Transcription]; Region: MarR; COG1846 762550004932 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 762550004933 putative phosphoesterase; Region: acc_ester; TIGR03729 762550004934 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 762550004935 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 762550004936 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 762550004937 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 762550004938 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 762550004939 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 762550004940 active site 762550004941 HIGH motif; other site 762550004942 KMSKS motif; other site 762550004943 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 762550004944 tRNA binding surface [nucleotide binding]; other site 762550004945 anticodon binding site; other site 762550004946 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 762550004947 dimer interface [polypeptide binding]; other site 762550004948 putative tRNA-binding site [nucleotide binding]; other site 762550004949 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 762550004950 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550004951 Zn2+ binding site [ion binding]; other site 762550004952 Mg2+ binding site [ion binding]; other site 762550004953 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 762550004954 Predicted membrane protein [Function unknown]; Region: COG4640 762550004955 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 762550004956 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 762550004957 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 762550004958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762550004959 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 762550004960 active site 762550004961 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550004962 catalytic core [active] 762550004963 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 762550004964 Melibiase; Region: Melibiase; pfam02065 762550004965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550004966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550004967 DNA binding site [nucleotide binding] 762550004968 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550004969 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 762550004970 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 762550004971 putative catalytic cysteine [active] 762550004972 gamma-glutamyl kinase; Provisional; Region: PRK05429 762550004973 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 762550004974 nucleotide binding site [chemical binding]; other site 762550004975 homotetrameric interface [polypeptide binding]; other site 762550004976 putative phosphate binding site [ion binding]; other site 762550004977 putative allosteric binding site; other site 762550004978 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 762550004979 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 762550004980 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 762550004981 active site 762550004982 Zn binding site [ion binding]; other site 762550004983 Domain of unknown function (DUF368); Region: DUF368; cl00893 762550004984 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 762550004985 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762550004986 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 762550004987 Predicted membrane protein [Function unknown]; Region: COG4709 762550004988 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550004989 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762550004990 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 762550004991 thiamine phosphate binding site [chemical binding]; other site 762550004992 active site 762550004993 pyrophosphate binding site [ion binding]; other site 762550004994 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 762550004995 dimer interface [polypeptide binding]; other site 762550004996 substrate binding site [chemical binding]; other site 762550004997 ATP binding site [chemical binding]; other site 762550004998 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 762550004999 substrate binding site [chemical binding]; other site 762550005000 multimerization interface [polypeptide binding]; other site 762550005001 ATP binding site [chemical binding]; other site 762550005002 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 762550005003 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 762550005004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550005005 Walker A motif; other site 762550005006 ATP binding site [chemical binding]; other site 762550005007 Walker B motif; other site 762550005008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005009 NADH(P)-binding; Region: NAD_binding_10; pfam13460 762550005010 NAD(P) binding site [chemical binding]; other site 762550005011 active site 762550005012 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 762550005013 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 762550005014 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 762550005015 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 762550005016 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 762550005017 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 762550005018 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 762550005019 Sugar transport protein; Region: Sugar_transport; pfam06800 762550005020 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 762550005021 dimerization interface [polypeptide binding]; other site 762550005022 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 762550005023 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 762550005024 propionate/acetate kinase; Provisional; Region: PRK12379 762550005025 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 762550005026 Methyltransferase domain; Region: Methyltransf_26; pfam13659 762550005027 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 762550005028 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 762550005029 amidase catalytic site [active] 762550005030 Zn binding residues [ion binding]; other site 762550005031 substrate binding site [chemical binding]; other site 762550005032 Phage holin; Region: Phage_holin_5; pfam06946 762550005033 Homeobox associated leucine zipper; Region: HALZ; cl02577 762550005034 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 762550005035 Phage tail protein; Region: Sipho_tail; cl17486 762550005036 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 762550005037 Phage-related protein [Function unknown]; Region: COG5412 762550005038 membrane protein P6; Region: PHA01399 762550005039 Phage protein; Region: DUF3647; pfam12363 762550005040 Phage major tail protein 2; Region: Phage_tail_2; cl11463 762550005041 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 762550005042 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 762550005043 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 762550005044 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 762550005045 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 762550005046 Phage terminase large subunit; Region: Terminase_3; cl12054 762550005047 Terminase-like family; Region: Terminase_6; pfam03237 762550005048 Homeodomain-like domain; Region: HTH_23; pfam13384 762550005049 Terminase small subunit; Region: Terminase_2; cl01513 762550005050 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 762550005051 Protein of unknown function (DUF722); Region: DUF722; pfam05263 762550005052 Endodeoxyribonuclease RusA; Region: RusA; cl01885 762550005053 Protein of unknown function (DUF968); Region: DUF968; pfam06147 762550005054 ERF superfamily; Region: ERF; pfam04404 762550005055 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 762550005056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 762550005057 sequence-specific DNA binding site [nucleotide binding]; other site 762550005058 salt bridge; other site 762550005059 AntA/AntB antirepressor; Region: AntA; cl01430 762550005060 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 762550005061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005062 non-specific DNA binding site [nucleotide binding]; other site 762550005063 salt bridge; other site 762550005064 sequence-specific DNA binding site [nucleotide binding]; other site 762550005065 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 762550005066 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 762550005067 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 762550005068 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 762550005069 catalytic residues [active] 762550005070 catalytic nucleophile [active] 762550005071 Recombinase; Region: Recombinase; pfam07508 762550005072 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 762550005073 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 762550005074 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762550005075 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 762550005076 Type II/IV secretion system protein; Region: T2SE; pfam00437 762550005077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 762550005078 Walker A motif; other site 762550005079 ATP binding site [chemical binding]; other site 762550005080 Walker B motif; other site 762550005081 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 762550005082 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 762550005083 active site 762550005084 dimer interface [polypeptide binding]; other site 762550005085 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 762550005086 dimer interface [polypeptide binding]; other site 762550005087 active site 762550005088 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 762550005089 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 762550005090 active site 762550005091 trimer interface [polypeptide binding]; other site 762550005092 allosteric site; other site 762550005093 active site lid [active] 762550005094 hexamer (dimer of trimers) interface [polypeptide binding]; other site 762550005095 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 762550005096 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 762550005097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 762550005098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 762550005099 dimer interface [polypeptide binding]; other site 762550005100 phosphorylation site [posttranslational modification] 762550005101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 762550005102 ATP binding site [chemical binding]; other site 762550005103 Mg2+ binding site [ion binding]; other site 762550005104 G-X-G motif; other site 762550005105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 762550005106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 762550005107 active site 762550005108 phosphorylation site [posttranslational modification] 762550005109 intermolecular recognition site; other site 762550005110 dimerization interface [polypeptide binding]; other site 762550005111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 762550005112 DNA binding site [nucleotide binding] 762550005113 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 762550005114 GTP-binding protein YchF; Reviewed; Region: PRK09601 762550005115 YchF GTPase; Region: YchF; cd01900 762550005116 G1 box; other site 762550005117 GTP/Mg2+ binding site [chemical binding]; other site 762550005118 Switch I region; other site 762550005119 G2 box; other site 762550005120 Switch II region; other site 762550005121 G3 box; other site 762550005122 G4 box; other site 762550005123 G5 box; other site 762550005124 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 762550005125 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 762550005126 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 762550005127 ParB-like nuclease domain; Region: ParB; smart00470 762550005128 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 762550005129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762550005130 P-loop; other site 762550005131 Magnesium ion binding site [ion binding]; other site 762550005132 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 762550005133 Magnesium ion binding site [ion binding]; other site 762550005134 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 762550005135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550005136 S-adenosylmethionine binding site [chemical binding]; other site 762550005137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550005138 dimerization interface [polypeptide binding]; other site 762550005139 putative DNA binding site [nucleotide binding]; other site 762550005140 putative Zn2+ binding site [ion binding]; other site 762550005141 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 762550005142 Ligand Binding Site [chemical binding]; other site 762550005143 manganese transport protein MntH; Reviewed; Region: PRK00701 762550005144 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 762550005145 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 762550005146 NAD-dependent deacetylase; Provisional; Region: PRK00481 762550005147 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 762550005148 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 762550005149 nucleophile elbow; other site 762550005150 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 762550005151 homodimer interface [polypeptide binding]; other site 762550005152 catalytic residues [active] 762550005153 NAD binding site [chemical binding]; other site 762550005154 substrate binding pocket [chemical binding]; other site 762550005155 flexible flap; other site 762550005156 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762550005157 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550005158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 762550005159 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 762550005160 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762550005161 active site 762550005162 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550005163 FemAB family; Region: FemAB; pfam02388 762550005164 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 762550005165 NlpC/P60 family; Region: NLPC_P60; cl17555 762550005166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550005167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 762550005168 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 762550005169 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 762550005170 dimer interface [polypeptide binding]; other site 762550005171 active site 762550005172 CoA binding pocket [chemical binding]; other site 762550005173 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 762550005174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 762550005175 active site 762550005176 HIGH motif; other site 762550005177 nucleotide binding site [chemical binding]; other site 762550005178 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 762550005179 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 762550005180 active site 762550005181 KMSKS motif; other site 762550005182 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 762550005183 tRNA binding surface [nucleotide binding]; other site 762550005184 anticodon binding site; other site 762550005185 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 762550005186 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 762550005187 Acyltransferase family; Region: Acyl_transf_3; pfam01757 762550005188 PemK-like protein; Region: PemK; pfam02452 762550005189 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 762550005190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 762550005191 active site 762550005192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 762550005193 dimer interface [polypeptide binding]; other site 762550005194 substrate binding site [chemical binding]; other site 762550005195 catalytic residues [active] 762550005196 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 762550005197 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 762550005198 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 762550005199 aromatic amino acid aminotransferase; Validated; Region: PRK07309 762550005200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550005201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550005202 homodimer interface [polypeptide binding]; other site 762550005203 catalytic residue [active] 762550005204 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 762550005205 active site 762550005206 amino acid transporter; Region: 2A0306; TIGR00909 762550005207 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 762550005208 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 762550005209 30S subunit binding site; other site 762550005210 comF family protein; Region: comF; TIGR00201 762550005211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550005212 active site 762550005213 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 762550005214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 762550005215 ATP binding site [chemical binding]; other site 762550005216 putative Mg++ binding site [ion binding]; other site 762550005217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 762550005218 nucleotide binding region [chemical binding]; other site 762550005219 ATP-binding site [chemical binding]; other site 762550005220 Uncharacterized conserved protein [Function unknown]; Region: COG1739 762550005221 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 762550005222 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 762550005223 exopolyphosphatase; Region: exo_poly_only; TIGR03706 762550005224 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550005225 polyphosphate kinase; Provisional; Region: PRK05443 762550005226 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 762550005227 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 762550005228 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 762550005229 putative domain interface [polypeptide binding]; other site 762550005230 putative active site [active] 762550005231 catalytic site [active] 762550005232 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 762550005233 putative domain interface [polypeptide binding]; other site 762550005234 putative active site [active] 762550005235 catalytic site [active] 762550005236 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 762550005237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 762550005238 Zn2+ binding site [ion binding]; other site 762550005239 Mg2+ binding site [ion binding]; other site 762550005240 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 762550005241 enolase; Provisional; Region: eno; PRK00077 762550005242 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 762550005243 dimer interface [polypeptide binding]; other site 762550005244 metal binding site [ion binding]; metal-binding site 762550005245 substrate binding pocket [chemical binding]; other site 762550005246 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 762550005247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 762550005248 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 762550005249 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 762550005250 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 762550005251 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 762550005252 active site 762550005253 metal binding site [ion binding]; metal-binding site 762550005254 dimerization interface [polypeptide binding]; other site 762550005255 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 762550005256 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 762550005257 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 762550005258 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 762550005259 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 762550005260 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 762550005261 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 762550005262 DNA binding site [nucleotide binding] 762550005263 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 762550005264 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 762550005265 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 762550005266 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 762550005267 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 762550005268 RPB1 interaction site [polypeptide binding]; other site 762550005269 RPB10 interaction site [polypeptide binding]; other site 762550005270 RPB11 interaction site [polypeptide binding]; other site 762550005271 RPB3 interaction site [polypeptide binding]; other site 762550005272 RPB12 interaction site [polypeptide binding]; other site 762550005273 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 762550005274 triosephosphate isomerase; Provisional; Region: PRK14565 762550005275 substrate binding site [chemical binding]; other site 762550005276 dimer interface [polypeptide binding]; other site 762550005277 catalytic triad [active] 762550005278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550005279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005280 non-specific DNA binding site [nucleotide binding]; other site 762550005281 salt bridge; other site 762550005282 sequence-specific DNA binding site [nucleotide binding]; other site 762550005283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 762550005284 DNA-binding site [nucleotide binding]; DNA binding site 762550005285 RNA-binding motif; other site 762550005286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550005287 catalytic core [active] 762550005288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550005289 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 762550005290 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 762550005291 active site 762550005292 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 762550005293 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 762550005294 dimer interface [polypeptide binding]; other site 762550005295 putative radical transfer pathway; other site 762550005296 diiron center [ion binding]; other site 762550005297 tyrosyl radical; other site 762550005298 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 762550005299 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 762550005300 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 762550005301 Class I ribonucleotide reductase; Region: RNR_I; cd01679 762550005302 active site 762550005303 dimer interface [polypeptide binding]; other site 762550005304 catalytic residues [active] 762550005305 effector binding site; other site 762550005306 R2 peptide binding site; other site 762550005307 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 762550005308 catalytic residues [active] 762550005309 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 762550005310 Domain of unknown function DUF21; Region: DUF21; pfam01595 762550005311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 762550005312 Transporter associated domain; Region: CorC_HlyC; smart01091 762550005313 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 762550005314 catalytic core [active] 762550005315 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 762550005316 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 762550005317 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 762550005318 HflX GTPase family; Region: HflX; cd01878 762550005319 G1 box; other site 762550005320 GTP/Mg2+ binding site [chemical binding]; other site 762550005321 Switch I region; other site 762550005322 G2 box; other site 762550005323 G3 box; other site 762550005324 Switch II region; other site 762550005325 G4 box; other site 762550005326 G5 box; other site 762550005327 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 762550005328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005329 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005331 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 762550005332 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 762550005333 23S rRNA interface [nucleotide binding]; other site 762550005334 L3 interface [polypeptide binding]; other site 762550005335 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 762550005336 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 762550005337 dimerization interface 3.5A [polypeptide binding]; other site 762550005338 active site 762550005339 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 762550005340 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 762550005341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550005342 Walker A/P-loop; other site 762550005343 ATP binding site [chemical binding]; other site 762550005344 Q-loop/lid; other site 762550005345 ABC transporter signature motif; other site 762550005346 Walker B; other site 762550005347 D-loop; other site 762550005348 H-loop/switch region; other site 762550005349 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 762550005350 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 762550005351 Walker A/P-loop; other site 762550005352 ATP binding site [chemical binding]; other site 762550005353 Q-loop/lid; other site 762550005354 ABC transporter signature motif; other site 762550005355 Walker B; other site 762550005356 D-loop; other site 762550005357 H-loop/switch region; other site 762550005358 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 762550005359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550005360 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 762550005361 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 762550005362 substrate binding pocket [chemical binding]; other site 762550005363 chain length determination region; other site 762550005364 substrate-Mg2+ binding site; other site 762550005365 catalytic residues [active] 762550005366 aspartate-rich region 1; other site 762550005367 active site lid residues [active] 762550005368 aspartate-rich region 2; other site 762550005369 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 762550005370 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 762550005371 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 762550005372 alphaNTD - beta interaction site [polypeptide binding]; other site 762550005373 alphaNTD homodimer interface [polypeptide binding]; other site 762550005374 alphaNTD - beta' interaction site [polypeptide binding]; other site 762550005375 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 762550005376 30S ribosomal protein S11; Validated; Region: PRK05309 762550005377 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 762550005378 30S ribosomal protein S13; Region: bact_S13; TIGR03631 762550005379 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 762550005380 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 762550005381 rRNA binding site [nucleotide binding]; other site 762550005382 predicted 30S ribosome binding site; other site 762550005383 adenylate kinase; Reviewed; Region: adk; PRK00279 762550005384 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 762550005385 AMP-binding site [chemical binding]; other site 762550005386 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 762550005387 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 762550005388 SecY translocase; Region: SecY; pfam00344 762550005389 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 762550005390 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 762550005391 23S rRNA binding site - archaea [nucleotide binding]; other site 762550005392 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 762550005393 5S rRNA binding site - archaea; other site 762550005394 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 762550005395 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 762550005396 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 762550005397 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 762550005398 5S rRNA interface [nucleotide binding]; other site 762550005399 L27 interface [polypeptide binding]; other site 762550005400 23S rRNA interface [nucleotide binding]; other site 762550005401 L5 interface [polypeptide binding]; other site 762550005402 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 762550005403 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762550005404 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 762550005405 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 762550005406 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 762550005407 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 762550005408 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 762550005409 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 762550005410 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 762550005411 RNA binding site [nucleotide binding]; other site 762550005412 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 762550005413 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 762550005414 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 762550005415 putative translocon interaction site; other site 762550005416 23S rRNA interface [nucleotide binding]; other site 762550005417 signal recognition particle (SRP54) interaction site; other site 762550005418 L23 interface [polypeptide binding]; other site 762550005419 trigger factor interaction site; other site 762550005420 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 762550005421 23S rRNA interface [nucleotide binding]; other site 762550005422 5S rRNA interface [nucleotide binding]; other site 762550005423 putative antibiotic binding site [chemical binding]; other site 762550005424 L25 interface [polypeptide binding]; other site 762550005425 L27 interface [polypeptide binding]; other site 762550005426 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 762550005427 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 762550005428 G-X-X-G motif; other site 762550005429 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 762550005430 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 762550005431 putative translocon binding site; other site 762550005432 protein-rRNA interface [nucleotide binding]; other site 762550005433 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 762550005434 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 762550005435 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 762550005436 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 762550005437 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 762550005438 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 762550005439 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 762550005440 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 762550005441 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 762550005442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 762550005443 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 762550005444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550005445 dimer interface [polypeptide binding]; other site 762550005446 conserved gate region; other site 762550005447 ABC-ATPase subunit interface; other site 762550005448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550005449 dimer interface [polypeptide binding]; other site 762550005450 conserved gate region; other site 762550005451 putative PBP binding loops; other site 762550005452 ABC-ATPase subunit interface; other site 762550005453 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 762550005454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550005455 Walker A/P-loop; other site 762550005456 ATP binding site [chemical binding]; other site 762550005457 Q-loop/lid; other site 762550005458 ABC transporter signature motif; other site 762550005459 Walker B; other site 762550005460 D-loop; other site 762550005461 H-loop/switch region; other site 762550005462 TOBE domain; Region: TOBE_2; pfam08402 762550005463 cyanate transporter; Region: CynX; TIGR00896 762550005464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005465 putative substrate translocation pore; other site 762550005466 elongation factor G; Reviewed; Region: PRK12739 762550005467 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 762550005468 G1 box; other site 762550005469 putative GEF interaction site [polypeptide binding]; other site 762550005470 GTP/Mg2+ binding site [chemical binding]; other site 762550005471 Switch I region; other site 762550005472 G2 box; other site 762550005473 G3 box; other site 762550005474 Switch II region; other site 762550005475 G4 box; other site 762550005476 G5 box; other site 762550005477 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 762550005478 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 762550005479 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 762550005480 30S ribosomal protein S7; Validated; Region: PRK05302 762550005481 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 762550005482 S17 interaction site [polypeptide binding]; other site 762550005483 S8 interaction site; other site 762550005484 16S rRNA interaction site [nucleotide binding]; other site 762550005485 streptomycin interaction site [chemical binding]; other site 762550005486 23S rRNA interaction site [nucleotide binding]; other site 762550005487 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 762550005488 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 762550005489 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 762550005490 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 762550005491 Clp amino terminal domain; Region: Clp_N; pfam02861 762550005492 Clp amino terminal domain; Region: Clp_N; pfam02861 762550005493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550005494 Walker A motif; other site 762550005495 ATP binding site [chemical binding]; other site 762550005496 Walker B motif; other site 762550005497 arginine finger; other site 762550005498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 762550005499 Walker A motif; other site 762550005500 ATP binding site [chemical binding]; other site 762550005501 Walker B motif; other site 762550005502 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 762550005503 peptide chain release factor 2; Validated; Region: prfB; PRK00578 762550005504 PCRF domain; Region: PCRF; pfam03462 762550005505 RF-1 domain; Region: RF-1; pfam00472 762550005506 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 762550005507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 762550005508 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 762550005509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 762550005510 nucleotide binding region [chemical binding]; other site 762550005511 ATP-binding site [chemical binding]; other site 762550005512 seryl-tRNA synthetase; Provisional; Region: PRK05431 762550005513 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 762550005514 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 762550005515 dimer interface [polypeptide binding]; other site 762550005516 active site 762550005517 motif 1; other site 762550005518 motif 2; other site 762550005519 motif 3; other site 762550005520 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 762550005521 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762550005522 active site 762550005523 HIGH motif; other site 762550005524 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 762550005525 KMSKS motif; other site 762550005526 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 762550005527 tRNA binding surface [nucleotide binding]; other site 762550005528 anticodon binding site; other site 762550005529 Phosphoglycerate kinase; Region: PGK; pfam00162 762550005530 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 762550005531 substrate binding site [chemical binding]; other site 762550005532 hinge regions; other site 762550005533 ADP binding site [chemical binding]; other site 762550005534 catalytic site [active] 762550005535 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 762550005536 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 762550005537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 762550005538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005540 putative substrate translocation pore; other site 762550005541 pantothenate kinase; Provisional; Region: PRK05439 762550005542 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 762550005543 active site 762550005544 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 762550005545 Part of AAA domain; Region: AAA_19; pfam13245 762550005546 Family description; Region: UvrD_C_2; pfam13538 762550005547 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 762550005548 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 762550005549 putative active site [active] 762550005550 putative FMN binding site [chemical binding]; other site 762550005551 putative substrate binding site [chemical binding]; other site 762550005552 putative catalytic residue [active] 762550005553 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 762550005554 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 762550005555 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 762550005556 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 762550005557 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 762550005558 active site 762550005559 metal binding site [ion binding]; metal-binding site 762550005560 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 762550005561 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762550005562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550005563 dimer interface [polypeptide binding]; other site 762550005564 conserved gate region; other site 762550005565 ABC-ATPase subunit interface; other site 762550005566 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 762550005567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 762550005568 dimer interface [polypeptide binding]; other site 762550005569 conserved gate region; other site 762550005570 putative PBP binding loops; other site 762550005571 ABC-ATPase subunit interface; other site 762550005572 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 762550005573 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 762550005574 Walker A/P-loop; other site 762550005575 ATP binding site [chemical binding]; other site 762550005576 Q-loop/lid; other site 762550005577 ABC transporter signature motif; other site 762550005578 Walker B; other site 762550005579 D-loop; other site 762550005580 H-loop/switch region; other site 762550005581 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 762550005582 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 762550005583 putative transposase OrfB; Reviewed; Region: PHA02517 762550005584 HTH-like domain; Region: HTH_21; pfam13276 762550005585 Integrase core domain; Region: rve; pfam00665 762550005586 Integrase core domain; Region: rve_2; pfam13333 762550005587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550005588 Transposase; Region: HTH_Tnp_1; cl17663 762550005589 Helix-turn-helix domain; Region: HTH_28; pfam13518 762550005590 Homeodomain-like domain; Region: HTH_32; pfam13565 762550005591 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 762550005592 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 762550005593 gamma subunit interface [polypeptide binding]; other site 762550005594 epsilon subunit interface [polypeptide binding]; other site 762550005595 LBP interface [polypeptide binding]; other site 762550005596 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 762550005597 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762550005598 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 762550005599 alpha subunit interaction interface [polypeptide binding]; other site 762550005600 Walker A motif; other site 762550005601 ATP binding site [chemical binding]; other site 762550005602 Walker B motif; other site 762550005603 inhibitor binding site; inhibition site 762550005604 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762550005605 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 762550005606 core domain interface [polypeptide binding]; other site 762550005607 delta subunit interface [polypeptide binding]; other site 762550005608 epsilon subunit interface [polypeptide binding]; other site 762550005609 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 762550005610 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 762550005611 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 762550005612 beta subunit interaction interface [polypeptide binding]; other site 762550005613 Walker A motif; other site 762550005614 ATP binding site [chemical binding]; other site 762550005615 Walker B motif; other site 762550005616 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 762550005617 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 762550005618 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 762550005619 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 762550005620 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 762550005621 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 762550005622 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 762550005623 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 762550005624 uracil transporter; Provisional; Region: PRK10720 762550005625 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 762550005626 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 762550005627 G1 box; other site 762550005628 GTP/Mg2+ binding site [chemical binding]; other site 762550005629 G2 box; other site 762550005630 Switch I region; other site 762550005631 G3 box; other site 762550005632 Switch II region; other site 762550005633 G4 box; other site 762550005634 G5 box; other site 762550005635 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 762550005636 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 762550005637 active site 762550005638 zinc binding site [ion binding]; other site 762550005639 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 762550005640 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 762550005641 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 762550005642 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 762550005643 EDD domain protein, DegV family; Region: DegV; TIGR00762 762550005644 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 762550005645 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 762550005646 CrcB-like protein; Region: CRCB; pfam02537 762550005647 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550005648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005649 non-specific DNA binding site [nucleotide binding]; other site 762550005650 salt bridge; other site 762550005651 sequence-specific DNA binding site [nucleotide binding]; other site 762550005652 short chain dehydrogenase; Validated; Region: PRK06182 762550005653 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 762550005654 NADP binding site [chemical binding]; other site 762550005655 active site 762550005656 steroid binding site; other site 762550005657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005658 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 762550005659 NAD(P) binding site [chemical binding]; other site 762550005660 active site 762550005661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550005662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005663 non-specific DNA binding site [nucleotide binding]; other site 762550005664 salt bridge; other site 762550005665 sequence-specific DNA binding site [nucleotide binding]; other site 762550005666 potential frameshift: common BLAST hit: gi|73661547|ref|YP_300328.1| phosphotransferase system cellobiose-specific component IIC 762550005667 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762550005668 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 762550005669 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762550005670 Uncharacterized conserved protein [Function unknown]; Region: COG3589 762550005671 Uncharacterized conserved protein [Function unknown]; Region: COG3589 762550005672 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 762550005673 active site 762550005674 P-loop; other site 762550005675 phosphorylation site [posttranslational modification] 762550005676 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550005677 active site 762550005678 methionine cluster; other site 762550005679 phosphorylation site [posttranslational modification] 762550005680 metal binding site [ion binding]; metal-binding site 762550005681 amino acid transporter; Region: 2A0306; TIGR00909 762550005682 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 762550005683 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 762550005684 intersubunit interface [polypeptide binding]; other site 762550005685 active site 762550005686 Zn2+ binding site [ion binding]; other site 762550005687 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 762550005688 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 762550005689 AP (apurinic/apyrimidinic) site pocket; other site 762550005690 DNA interaction; other site 762550005691 Metal-binding active site; metal-binding site 762550005692 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 762550005693 active site 762550005694 dimer interface [polypeptide binding]; other site 762550005695 magnesium binding site [ion binding]; other site 762550005696 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 762550005697 active site 762550005698 P-loop; other site 762550005699 phosphorylation site [posttranslational modification] 762550005700 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 762550005701 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 762550005702 active site 762550005703 phosphorylation site [posttranslational modification] 762550005704 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 762550005705 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 762550005706 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 762550005707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550005708 active site 762550005709 motif I; other site 762550005710 motif II; other site 762550005711 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762550005712 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 762550005713 metal binding site 2 [ion binding]; metal-binding site 762550005714 putative DNA binding helix; other site 762550005715 metal binding site 1 [ion binding]; metal-binding site 762550005716 dimer interface [polypeptide binding]; other site 762550005717 structural Zn2+ binding site [ion binding]; other site 762550005718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 762550005719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 762550005720 DNA binding site [nucleotide binding] 762550005721 domain linker motif; other site 762550005722 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 762550005723 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 762550005724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005725 putative substrate translocation pore; other site 762550005726 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 762550005727 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 762550005728 Ca binding site [ion binding]; other site 762550005729 active site 762550005730 catalytic site [active] 762550005731 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 762550005732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 762550005733 dimerization interface [polypeptide binding]; other site 762550005734 putative DNA binding site [nucleotide binding]; other site 762550005735 putative Zn2+ binding site [ion binding]; other site 762550005736 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 762550005737 Cadmium resistance transporter; Region: Cad; pfam03596 762550005738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005740 putative substrate translocation pore; other site 762550005741 Predicted transcriptional regulators [Transcription]; Region: COG1733 762550005742 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 762550005743 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 762550005744 zinc binding site [ion binding]; other site 762550005745 putative ligand binding site [chemical binding]; other site 762550005746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762550005747 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 762550005748 TM-ABC transporter signature motif; other site 762550005749 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 762550005750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550005751 Walker A/P-loop; other site 762550005752 ATP binding site [chemical binding]; other site 762550005753 Q-loop/lid; other site 762550005754 ABC transporter signature motif; other site 762550005755 Walker B; other site 762550005756 D-loop; other site 762550005757 H-loop/switch region; other site 762550005758 K+ potassium transporter; Region: K_trans; pfam02705 762550005759 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 762550005760 tetramer (dimer of dimers) interface [polypeptide binding]; other site 762550005761 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 762550005762 NAD binding site [chemical binding]; other site 762550005763 dimer interface [polypeptide binding]; other site 762550005764 substrate binding site [chemical binding]; other site 762550005765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 762550005766 Transposase; Region: HTH_Tnp_1; cl17663 762550005767 Helix-turn-helix domain; Region: HTH_28; pfam13518 762550005768 Homeodomain-like domain; Region: HTH_32; pfam13565 762550005769 putative transposase OrfB; Reviewed; Region: PHA02517 762550005770 HTH-like domain; Region: HTH_21; pfam13276 762550005771 Integrase core domain; Region: rve; pfam00665 762550005772 Integrase core domain; Region: rve_2; pfam13333 762550005773 AAA domain; Region: AAA_22; pfam13401 762550005774 AAA domain; Region: AAA_21; pfam13304 762550005775 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 762550005776 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 762550005777 putative active site [active] 762550005778 putative metal-binding site [ion binding]; other site 762550005779 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 762550005780 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 762550005781 putative active site [active] 762550005782 putative NTP binding site [chemical binding]; other site 762550005783 putative nucleic acid binding site [nucleotide binding]; other site 762550005784 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 762550005785 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 762550005786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005788 ABC-2 type transporter; Region: ABC2_membrane; cl17235 762550005789 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 762550005790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550005791 Walker A/P-loop; other site 762550005792 ATP binding site [chemical binding]; other site 762550005793 Q-loop/lid; other site 762550005794 ABC transporter signature motif; other site 762550005795 Walker B; other site 762550005796 D-loop; other site 762550005797 H-loop/switch region; other site 762550005798 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 762550005799 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 762550005800 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 762550005801 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 762550005802 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 762550005803 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 762550005804 putative NADP binding site [chemical binding]; other site 762550005805 active site 762550005806 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 762550005807 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 762550005808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 762550005809 catalytic residue [active] 762550005810 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 762550005811 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 762550005812 active site 762550005813 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 762550005814 active site 762550005815 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 762550005816 Integrase core domain; Region: rve; pfam00665 762550005817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 762550005818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 762550005819 non-specific DNA binding site [nucleotide binding]; other site 762550005820 salt bridge; other site 762550005821 sequence-specific DNA binding site [nucleotide binding]; other site 762550005822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 762550005823 Predicted helicase [General function prediction only]; Region: COG4889 762550005824 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 762550005825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005826 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 762550005827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 762550005828 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 762550005829 Walker A/P-loop; other site 762550005830 ATP binding site [chemical binding]; other site 762550005831 Q-loop/lid; other site 762550005832 ABC transporter signature motif; other site 762550005833 Walker B; other site 762550005834 D-loop; other site 762550005835 H-loop/switch region; other site 762550005836 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762550005837 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762550005838 TM-ABC transporter signature motif; other site 762550005839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 762550005840 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 762550005841 TM-ABC transporter signature motif; other site 762550005842 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 762550005843 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 762550005844 Walker A/P-loop; other site 762550005845 ATP binding site [chemical binding]; other site 762550005846 Q-loop/lid; other site 762550005847 ABC transporter signature motif; other site 762550005848 Walker B; other site 762550005849 D-loop; other site 762550005850 H-loop/switch region; other site 762550005851 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 762550005852 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 762550005853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005857 putative substrate translocation pore; other site 762550005858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005859 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 762550005860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 762550005861 NAD(P) binding site [chemical binding]; other site 762550005862 active site 762550005863 Predicted transcriptional regulator [Transcription]; Region: COG1959 762550005864 Transcriptional regulator; Region: Rrf2; pfam02082 762550005865 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 762550005866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005868 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 762550005869 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 762550005870 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 762550005871 TrkA-N domain; Region: TrkA_N; pfam02254 762550005872 TrkA-C domain; Region: TrkA_C; pfam02080 762550005873 D-lactate dehydrogenase; Provisional; Region: PRK11183 762550005874 FAD binding domain; Region: FAD_binding_4; pfam01565 762550005875 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 762550005876 OsmC-like protein; Region: OsmC; cl00767 762550005877 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550005878 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762550005879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005881 putative substrate translocation pore; other site 762550005882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005883 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 762550005884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 762550005885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 762550005886 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 762550005887 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 762550005888 active site 762550005889 methionine cluster; other site 762550005890 phosphorylation site [posttranslational modification] 762550005891 metal binding site [ion binding]; metal-binding site 762550005892 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 762550005893 active site 762550005894 P-loop; other site 762550005895 phosphorylation site [posttranslational modification] 762550005896 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 762550005897 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 762550005898 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 762550005899 beta-galactosidase; Region: BGL; TIGR03356 762550005900 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 762550005901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 762550005902 DNA-binding site [nucleotide binding]; DNA binding site 762550005903 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 762550005904 Predicted transcriptional regulator [Transcription]; Region: COG2378 762550005905 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 762550005906 substrate binding site [chemical binding]; other site 762550005907 Predicted transcriptional regulators [Transcription]; Region: COG1695 762550005908 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 762550005909 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 762550005910 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 762550005911 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 762550005912 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 762550005913 heterotetramer interface [polypeptide binding]; other site 762550005914 active site pocket [active] 762550005915 cleavage site 762550005916 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 762550005917 nucleotide binding site [chemical binding]; other site 762550005918 N-acetyl-L-glutamate binding site [chemical binding]; other site 762550005919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 762550005920 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 762550005921 inhibitor-cofactor binding pocket; inhibition site 762550005922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550005923 catalytic residue [active] 762550005924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 762550005925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 762550005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005928 putative substrate translocation pore; other site 762550005929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005930 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 762550005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 762550005932 S-adenosylmethionine binding site [chemical binding]; other site 762550005933 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 762550005934 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 762550005935 acyl-activating enzyme (AAE) consensus motif; other site 762550005936 putative AMP binding site [chemical binding]; other site 762550005937 putative active site [active] 762550005938 putative CoA binding site [chemical binding]; other site 762550005939 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 762550005940 Penicillinase repressor; Region: Pencillinase_R; pfam03965 762550005941 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 762550005942 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 762550005943 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 762550005944 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 762550005945 amphipathic channel; other site 762550005946 Asn-Pro-Ala signature motifs; other site 762550005947 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 762550005948 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 762550005949 active site 762550005950 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 762550005951 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 762550005952 DNA binding residues [nucleotide binding] 762550005953 putative dimer interface [polypeptide binding]; other site 762550005954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 762550005955 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 762550005956 putative ADP-binding pocket [chemical binding]; other site 762550005957 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 762550005958 Sulfatase; Region: Sulfatase; pfam00884 762550005959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550005960 Coenzyme A binding pocket [chemical binding]; other site 762550005961 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 762550005962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550005963 active site 762550005964 motif I; other site 762550005965 motif II; other site 762550005966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 762550005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 762550005968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 762550005969 putative substrate translocation pore; other site 762550005970 transaminase; Reviewed; Region: PRK08068 762550005971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 762550005972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 762550005973 homodimer interface [polypeptide binding]; other site 762550005974 catalytic residue [active] 762550005975 Predicted amidohydrolase [General function prediction only]; Region: COG0388 762550005976 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 762550005977 putative active site [active] 762550005978 catalytic triad [active] 762550005979 putative dimer interface [polypeptide binding]; other site 762550005980 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 762550005981 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 762550005982 substrate binding site [chemical binding]; other site 762550005983 oxyanion hole (OAH) forming residues; other site 762550005984 trimer interface [polypeptide binding]; other site 762550005985 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 762550005986 CoenzymeA binding site [chemical binding]; other site 762550005987 subunit interaction site [polypeptide binding]; other site 762550005988 PHB binding site; other site 762550005989 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 762550005990 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 762550005991 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 762550005992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550005993 Coenzyme A binding pocket [chemical binding]; other site 762550005994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 762550005995 active site 762550005996 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 762550005997 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 762550005998 Cl binding site [ion binding]; other site 762550005999 oligomer interface [polypeptide binding]; other site 762550006000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 762550006001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 762550006002 Coenzyme A binding pocket [chemical binding]; other site 762550006003 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 762550006004 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 762550006005 active site 762550006006 catalytic site [active] 762550006007 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 762550006008 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 762550006009 ribonuclease P; Reviewed; Region: rnpA; PRK00499 762550006010 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 762550006011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 762550006012 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 762550006013 Walker A/P-loop; other site 762550006014 ATP binding site [chemical binding]; other site 762550006015 Q-loop/lid; other site 762550006016 ABC transporter signature motif; other site 762550006017 Walker B; other site 762550006018 D-loop; other site 762550006019 H-loop/switch region; other site 762550006020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 762550006021 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 762550006022 hypothetical protein; Provisional; Region: PRK12378 762550006023 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 762550006024 pseudouridine synthase; Region: TIGR00093 762550006025 probable active site [active]