-- dump date 20140619_131820 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1229756000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1229756000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1229756000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756000004 Walker A motif; other site 1229756000005 ATP binding site [chemical binding]; other site 1229756000006 Walker B motif; other site 1229756000007 arginine finger; other site 1229756000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1229756000009 DnaA box-binding interface [nucleotide binding]; other site 1229756000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1229756000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1229756000012 putative DNA binding surface [nucleotide binding]; other site 1229756000013 dimer interface [polypeptide binding]; other site 1229756000014 beta-clamp/clamp loader binding surface; other site 1229756000015 beta-clamp/translesion DNA polymerase binding surface; other site 1229756000016 S4 domain; Region: S4_2; pfam13275 1229756000017 recombination protein F; Reviewed; Region: recF; PRK00064 1229756000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1229756000019 Walker A/P-loop; other site 1229756000020 ATP binding site [chemical binding]; other site 1229756000021 Q-loop/lid; other site 1229756000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000023 ABC transporter signature motif; other site 1229756000024 Walker B; other site 1229756000025 D-loop; other site 1229756000026 H-loop/switch region; other site 1229756000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1229756000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756000029 Mg2+ binding site [ion binding]; other site 1229756000030 G-X-G motif; other site 1229756000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1229756000032 anchoring element; other site 1229756000033 dimer interface [polypeptide binding]; other site 1229756000034 ATP binding site [chemical binding]; other site 1229756000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1229756000036 active site 1229756000037 putative metal-binding site [ion binding]; other site 1229756000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1229756000039 DNA gyrase subunit A; Validated; Region: PRK05560 1229756000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1229756000041 CAP-like domain; other site 1229756000042 active site 1229756000043 primary dimer interface [polypeptide binding]; other site 1229756000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756000050 PspC domain; Region: PspC; pfam04024 1229756000051 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1229756000052 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1229756000053 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756000054 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1229756000055 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1229756000056 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1229756000057 HlyD family secretion protein; Region: HlyD_3; pfam13437 1229756000058 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756000059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756000060 Walker A/P-loop; other site 1229756000061 ATP binding site [chemical binding]; other site 1229756000062 Q-loop/lid; other site 1229756000063 ABC transporter signature motif; other site 1229756000064 Walker B; other site 1229756000065 D-loop; other site 1229756000066 H-loop/switch region; other site 1229756000067 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1229756000068 FtsX-like permease family; Region: FtsX; pfam02687 1229756000069 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 1229756000070 PB1 interaction site [polypeptide binding]; other site 1229756000071 PB1 interaction site [polypeptide binding]; other site 1229756000072 PB1 interaction surface [polypeptide binding]; other site 1229756000073 PB1 interaction surface [polypeptide binding]; other site 1229756000074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1229756000075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756000076 Coenzyme A binding pocket [chemical binding]; other site 1229756000077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1229756000078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000079 salt bridge; other site 1229756000080 non-specific DNA binding site [nucleotide binding]; other site 1229756000081 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000082 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1229756000083 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1229756000084 active site 1229756000085 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1229756000086 active site 1229756000087 tetramer interface [polypeptide binding]; other site 1229756000088 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1229756000089 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1229756000090 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1229756000091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756000092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756000093 DNA binding site [nucleotide binding] 1229756000094 domain linker motif; other site 1229756000095 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1229756000096 dimerization interface [polypeptide binding]; other site 1229756000097 ligand binding site [chemical binding]; other site 1229756000098 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1229756000099 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1229756000100 substrate binding site [chemical binding]; other site 1229756000101 dimer interface [polypeptide binding]; other site 1229756000102 ATP binding site [chemical binding]; other site 1229756000103 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1229756000104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1229756000105 active site 1229756000106 dimer interface [polypeptide binding]; other site 1229756000107 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1229756000108 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1229756000109 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1229756000110 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1229756000111 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756000112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000113 non-specific DNA binding site [nucleotide binding]; other site 1229756000114 salt bridge; other site 1229756000115 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000116 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1229756000117 potential frameshift: common BLAST hit: gi|300172340|ref|YP_003771505.1| cyclase 1229756000118 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1229756000119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756000120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000121 non-specific DNA binding site [nucleotide binding]; other site 1229756000122 salt bridge; other site 1229756000123 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000124 HTH-like domain; Region: HTH_21; pfam13276 1229756000125 Transposase; Region: HTH_Tnp_1; cl17663 1229756000126 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1229756000127 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1229756000128 putative active site [active] 1229756000129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756000130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000131 Walker A/P-loop; other site 1229756000132 ATP binding site [chemical binding]; other site 1229756000133 Q-loop/lid; other site 1229756000134 ABC transporter signature motif; other site 1229756000135 Walker B; other site 1229756000136 D-loop; other site 1229756000137 H-loop/switch region; other site 1229756000138 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1229756000139 HlyD family secretion protein; Region: HlyD_3; pfam13437 1229756000140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000141 non-specific DNA binding site [nucleotide binding]; other site 1229756000142 salt bridge; other site 1229756000143 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000144 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1229756000145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000146 dimer interface [polypeptide binding]; other site 1229756000147 conserved gate region; other site 1229756000148 putative PBP binding loops; other site 1229756000149 ABC-ATPase subunit interface; other site 1229756000150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756000151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756000152 substrate binding pocket [chemical binding]; other site 1229756000153 membrane-bound complex binding site; other site 1229756000154 hinge residues; other site 1229756000155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1229756000156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000157 dimer interface [polypeptide binding]; other site 1229756000158 conserved gate region; other site 1229756000159 putative PBP binding loops; other site 1229756000160 ABC-ATPase subunit interface; other site 1229756000161 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1229756000162 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1229756000163 Walker A/P-loop; other site 1229756000164 ATP binding site [chemical binding]; other site 1229756000165 Q-loop/lid; other site 1229756000166 ABC transporter signature motif; other site 1229756000167 Walker B; other site 1229756000168 D-loop; other site 1229756000169 H-loop/switch region; other site 1229756000170 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1229756000171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756000172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756000173 homodimer interface [polypeptide binding]; other site 1229756000174 catalytic residue [active] 1229756000175 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1229756000176 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1229756000177 homodimer interface [polypeptide binding]; other site 1229756000178 ligand binding site [chemical binding]; other site 1229756000179 NAD binding site [chemical binding]; other site 1229756000180 catalytic site [active] 1229756000181 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1229756000182 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1229756000183 Walker A/P-loop; other site 1229756000184 ATP binding site [chemical binding]; other site 1229756000185 Q-loop/lid; other site 1229756000186 ABC transporter signature motif; other site 1229756000187 Walker B; other site 1229756000188 D-loop; other site 1229756000189 H-loop/switch region; other site 1229756000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756000192 putative substrate translocation pore; other site 1229756000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000194 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1229756000195 EamA-like transporter family; Region: EamA; pfam00892 1229756000196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1229756000197 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1229756000198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1229756000199 YcaO-like family; Region: YcaO; pfam02624 1229756000200 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756000201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756000202 ABC transporter; Region: ABC_tran_2; pfam12848 1229756000203 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 1229756000204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756000205 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1229756000206 Citrate transporter; Region: CitMHS; pfam03600 1229756000207 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1229756000208 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1229756000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756000210 NAD(P) binding site [chemical binding]; other site 1229756000211 active site 1229756000212 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1229756000213 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1229756000214 putative ligand binding site [chemical binding]; other site 1229756000215 putative NAD binding site [chemical binding]; other site 1229756000216 catalytic site [active] 1229756000217 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756000218 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756000219 DNA binding site [nucleotide binding] 1229756000220 domain linker motif; other site 1229756000221 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1229756000222 putative dimerization interface [polypeptide binding]; other site 1229756000223 putative ligand binding site [chemical binding]; other site 1229756000224 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1229756000225 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1229756000226 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1229756000227 DNA binding residues [nucleotide binding] 1229756000228 putative dimer interface [polypeptide binding]; other site 1229756000229 CENP-B N-terminal DNA-binding domain; Region: CENP-B_N; pfam04218 1229756000230 CAAX protease self-immunity; Region: Abi; pfam02517 1229756000231 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 1229756000232 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1229756000233 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756000234 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756000235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756000236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756000237 Walker A/P-loop; other site 1229756000238 ATP binding site [chemical binding]; other site 1229756000239 Q-loop/lid; other site 1229756000240 ABC transporter signature motif; other site 1229756000241 Walker B; other site 1229756000242 D-loop; other site 1229756000243 H-loop/switch region; other site 1229756000244 FtsX-like permease family; Region: FtsX; pfam02687 1229756000245 FtsX-like permease family; Region: FtsX; pfam02687 1229756000246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756000247 putative DNA binding site [nucleotide binding]; other site 1229756000248 putative Zn2+ binding site [ion binding]; other site 1229756000249 MarR family; Region: MarR_2; cl17246 1229756000250 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1229756000251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756000252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000253 Walker A/P-loop; other site 1229756000254 ATP binding site [chemical binding]; other site 1229756000255 Q-loop/lid; other site 1229756000256 ABC transporter signature motif; other site 1229756000257 Walker B; other site 1229756000258 D-loop; other site 1229756000259 H-loop/switch region; other site 1229756000260 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1229756000261 Domain of unknown function DUF87; Region: DUF87; pfam01935 1229756000262 AAA-like domain; Region: AAA_10; pfam12846 1229756000263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756000264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756000265 DNA binding site [nucleotide binding] 1229756000266 domain linker motif; other site 1229756000267 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756000268 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1229756000269 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1229756000270 substrate binding [chemical binding]; other site 1229756000271 active site 1229756000272 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1229756000273 galactoside permease; Reviewed; Region: lacY; PRK09528 1229756000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000275 putative substrate translocation pore; other site 1229756000276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756000277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000278 salt bridge; other site 1229756000279 non-specific DNA binding site [nucleotide binding]; other site 1229756000280 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000281 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756000282 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1229756000283 Walker A/P-loop; other site 1229756000284 ATP binding site [chemical binding]; other site 1229756000285 Q-loop/lid; other site 1229756000286 ABC transporter signature motif; other site 1229756000287 Walker B; other site 1229756000288 D-loop; other site 1229756000289 H-loop/switch region; other site 1229756000290 Protein of unknown function (DUF975); Region: DUF975; cl10504 1229756000291 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756000292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000293 non-specific DNA binding site [nucleotide binding]; other site 1229756000294 salt bridge; other site 1229756000295 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000296 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1229756000297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000298 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1229756000299 Walker A/P-loop; other site 1229756000300 ATP binding site [chemical binding]; other site 1229756000301 Q-loop/lid; other site 1229756000302 ABC transporter signature motif; other site 1229756000303 Walker B; other site 1229756000304 D-loop; other site 1229756000305 H-loop/switch region; other site 1229756000306 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1229756000307 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1229756000308 active site 1229756000309 HIGH motif; other site 1229756000310 dimer interface [polypeptide binding]; other site 1229756000311 KMSKS motif; other site 1229756000312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756000313 RNA binding surface [nucleotide binding]; other site 1229756000314 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1229756000315 D-lactate dehydrogenase; Validated; Region: PRK08605 1229756000316 homodimer interface [polypeptide binding]; other site 1229756000317 ligand binding site [chemical binding]; other site 1229756000318 NAD binding site [chemical binding]; other site 1229756000319 catalytic site [active] 1229756000320 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1229756000321 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1229756000322 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1229756000323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000324 putative substrate translocation pore; other site 1229756000325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756000326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1229756000327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1229756000328 active site 1229756000329 metal binding site [ion binding]; metal-binding site 1229756000330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1229756000331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1229756000332 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756000333 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756000334 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1229756000335 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1229756000336 putative active site [active] 1229756000337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756000338 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1229756000339 putative active site [active] 1229756000340 COMC family; Region: ComC; pfam03047 1229756000341 CAAX protease self-immunity; Region: Abi; pfam02517 1229756000342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000343 non-specific DNA binding site [nucleotide binding]; other site 1229756000344 salt bridge; other site 1229756000345 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000346 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756000347 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756000348 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1229756000349 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1229756000350 putative NAD(P) binding site [chemical binding]; other site 1229756000351 dimer interface [polypeptide binding]; other site 1229756000352 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1229756000353 substrate binding site [chemical binding]; other site 1229756000354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756000355 dimerization interface [polypeptide binding]; other site 1229756000356 putative DNA binding site [nucleotide binding]; other site 1229756000357 putative Zn2+ binding site [ion binding]; other site 1229756000358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1229756000359 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1229756000360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756000362 putative substrate translocation pore; other site 1229756000363 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1229756000364 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1229756000365 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1229756000366 Walker A/P-loop; other site 1229756000367 ATP binding site [chemical binding]; other site 1229756000368 Q-loop/lid; other site 1229756000369 ABC transporter signature motif; other site 1229756000370 Walker B; other site 1229756000371 D-loop; other site 1229756000372 H-loop/switch region; other site 1229756000373 TOBE domain; Region: TOBE_2; pfam08402 1229756000374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000375 dimer interface [polypeptide binding]; other site 1229756000376 conserved gate region; other site 1229756000377 putative PBP binding loops; other site 1229756000378 ABC-ATPase subunit interface; other site 1229756000379 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1229756000380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000381 dimer interface [polypeptide binding]; other site 1229756000382 conserved gate region; other site 1229756000383 putative PBP binding loops; other site 1229756000384 ABC-ATPase subunit interface; other site 1229756000385 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1229756000386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1229756000387 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756000388 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1229756000389 active site 1229756000390 catalytic site [active] 1229756000391 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756000392 catalytic core [active] 1229756000393 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1229756000394 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1229756000395 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756000396 putative NAD(P) binding site [chemical binding]; other site 1229756000397 Surface antigen [General function prediction only]; Region: COG3942 1229756000398 CHAP domain; Region: CHAP; cl17642 1229756000399 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1229756000400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1229756000401 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1229756000402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1229756000403 active site 1229756000404 phosphorylation site [posttranslational modification] 1229756000405 intermolecular recognition site; other site 1229756000406 dimerization interface [polypeptide binding]; other site 1229756000407 LytTr DNA-binding domain; Region: LytTR; smart00850 1229756000408 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1229756000409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756000410 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1229756000411 active site 1229756000412 motif I; other site 1229756000413 motif II; other site 1229756000414 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1229756000415 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1229756000416 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1229756000417 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1229756000418 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1229756000419 CAT RNA binding domain; Region: CAT_RBD; smart01061 1229756000420 PRD domain; Region: PRD; pfam00874 1229756000421 PRD domain; Region: PRD; pfam00874 1229756000422 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1229756000423 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1229756000424 active site turn [active] 1229756000425 phosphorylation site [posttranslational modification] 1229756000426 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1229756000427 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1229756000428 HPr interaction site; other site 1229756000429 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1229756000430 active site 1229756000431 phosphorylation site [posttranslational modification] 1229756000432 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1229756000433 beta-galactosidase; Region: BGL; TIGR03356 1229756000434 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1229756000435 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1229756000436 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1229756000437 dimer interface [polypeptide binding]; other site 1229756000438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756000439 catalytic residue [active] 1229756000440 cystathionine beta-lyase; Provisional; Region: PRK07671 1229756000441 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1229756000442 homodimer interface [polypeptide binding]; other site 1229756000443 substrate-cofactor binding pocket; other site 1229756000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756000445 catalytic residue [active] 1229756000446 serine O-acetyltransferase; Region: cysE; TIGR01172 1229756000447 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1229756000448 trimer interface [polypeptide binding]; other site 1229756000449 active site 1229756000450 substrate binding site [chemical binding]; other site 1229756000451 CoA binding site [chemical binding]; other site 1229756000452 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1229756000453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756000454 DNA-binding site [nucleotide binding]; DNA binding site 1229756000455 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1229756000456 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1229756000457 Walker A/P-loop; other site 1229756000458 ATP binding site [chemical binding]; other site 1229756000459 Q-loop/lid; other site 1229756000460 ABC transporter signature motif; other site 1229756000461 Walker B; other site 1229756000462 D-loop; other site 1229756000463 H-loop/switch region; other site 1229756000464 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1229756000465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000466 Walker A/P-loop; other site 1229756000467 ATP binding site [chemical binding]; other site 1229756000468 Q-loop/lid; other site 1229756000469 ABC transporter signature motif; other site 1229756000470 Walker B; other site 1229756000471 D-loop; other site 1229756000472 H-loop/switch region; other site 1229756000473 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1229756000474 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1229756000475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1229756000476 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1229756000477 active site 1229756000478 catalytic tetrad [active] 1229756000479 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1229756000480 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1229756000481 metal binding site [ion binding]; metal-binding site 1229756000482 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1229756000483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756000484 putative DNA binding site [nucleotide binding]; other site 1229756000485 putative Zn2+ binding site [ion binding]; other site 1229756000486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756000487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756000488 Walker A/P-loop; other site 1229756000489 ATP binding site [chemical binding]; other site 1229756000490 Q-loop/lid; other site 1229756000491 ABC transporter signature motif; other site 1229756000492 Walker B; other site 1229756000493 D-loop; other site 1229756000494 H-loop/switch region; other site 1229756000495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756000496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756000497 active site 1229756000498 phosphorylation site [posttranslational modification] 1229756000499 intermolecular recognition site; other site 1229756000500 dimerization interface [polypeptide binding]; other site 1229756000501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756000502 DNA binding site [nucleotide binding] 1229756000503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1229756000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756000505 ATP binding site [chemical binding]; other site 1229756000506 Mg2+ binding site [ion binding]; other site 1229756000507 G-X-G motif; other site 1229756000508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1229756000509 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1229756000510 Walker A/P-loop; other site 1229756000511 ATP binding site [chemical binding]; other site 1229756000512 Q-loop/lid; other site 1229756000513 ABC transporter signature motif; other site 1229756000514 Walker B; other site 1229756000515 D-loop; other site 1229756000516 H-loop/switch region; other site 1229756000517 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1229756000518 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756000519 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1229756000520 putative active site [active] 1229756000521 catalytic site [active] 1229756000522 putative metal binding site [ion binding]; other site 1229756000523 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1229756000524 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1229756000525 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1229756000526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756000527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000528 putative substrate translocation pore; other site 1229756000529 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1229756000530 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1229756000531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756000532 ATP binding site [chemical binding]; other site 1229756000533 putative Mg++ binding site [ion binding]; other site 1229756000534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756000535 nucleotide binding region [chemical binding]; other site 1229756000536 ATP-binding site [chemical binding]; other site 1229756000537 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1229756000538 HRDC domain; Region: HRDC; pfam00570 1229756000539 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1229756000540 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1229756000541 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1229756000542 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1229756000543 inhibitor binding site; inhibition site 1229756000544 active site 1229756000545 WIF domain; Region: WIF; cl02623 1229756000546 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1229756000547 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1229756000548 nucleotide binding site [chemical binding]; other site 1229756000549 xylose isomerase; Provisional; Region: PRK05474 1229756000550 xylose isomerase; Region: xylose_isom_A; TIGR02630 1229756000551 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1229756000552 N- and C-terminal domain interface [polypeptide binding]; other site 1229756000553 D-xylulose kinase; Region: XylB; TIGR01312 1229756000554 active site 1229756000555 MgATP binding site [chemical binding]; other site 1229756000556 catalytic site [active] 1229756000557 metal binding site [ion binding]; metal-binding site 1229756000558 xylulose binding site [chemical binding]; other site 1229756000559 homodimer interface [polypeptide binding]; other site 1229756000560 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1229756000561 Helix-turn-helix domain; Region: HTH_38; pfam13936 1229756000562 Integrase core domain; Region: rve; pfam00665 1229756000563 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1229756000564 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1229756000565 active site 1229756000566 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1229756000567 transmembrane helices; other site 1229756000568 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1229756000569 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1229756000570 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1229756000571 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1229756000572 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1229756000573 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1229756000574 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1229756000575 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756000576 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1229756000577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1229756000578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1229756000579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1229756000580 dimerization interface [polypeptide binding]; other site 1229756000581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000582 benzoate transport; Region: 2A0115; TIGR00895 1229756000583 putative substrate translocation pore; other site 1229756000584 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1229756000585 nudix motif; other site 1229756000586 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1229756000587 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1229756000588 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1229756000589 acetoin reductase; Validated; Region: PRK08643 1229756000590 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1229756000591 NAD binding site [chemical binding]; other site 1229756000592 homotetramer interface [polypeptide binding]; other site 1229756000593 homodimer interface [polypeptide binding]; other site 1229756000594 active site 1229756000595 substrate binding site [chemical binding]; other site 1229756000596 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1229756000597 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1229756000598 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1229756000599 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1229756000600 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1229756000601 NAD(P) binding pocket [chemical binding]; other site 1229756000602 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 1229756000603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756000604 active site 1229756000605 nucleotide binding site [chemical binding]; other site 1229756000606 HIGH motif; other site 1229756000607 KMSKS motif; other site 1229756000608 citrate lyase subunit gamma; Provisional; Region: PRK13253 1229756000609 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1229756000610 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1229756000611 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1229756000612 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1229756000613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1229756000614 PGAP1-like protein; Region: PGAP1; pfam07819 1229756000615 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1229756000616 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1229756000617 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1229756000618 putative catalytic cysteine [active] 1229756000619 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1229756000620 putative active site [active] 1229756000621 metal binding site [ion binding]; metal-binding site 1229756000622 Predicted membrane protein [Function unknown]; Region: COG1511 1229756000623 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1229756000624 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1229756000625 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1229756000626 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1229756000627 Predicted transcriptional regulator [Transcription]; Region: COG1959 1229756000628 Transcriptional regulator; Region: Rrf2; pfam02082 1229756000629 Transcriptional regulator; Region: Rrf2; cl17282 1229756000630 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1229756000631 MarR family; Region: MarR; pfam01047 1229756000632 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1229756000633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756000634 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1229756000635 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756000636 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1229756000637 putative NAD(P) binding site [chemical binding]; other site 1229756000638 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1229756000639 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1229756000640 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1229756000641 active site 1229756000642 SH3-like domain; Region: SH3_8; pfam13457 1229756000643 SH3-like domain; Region: SH3_8; pfam13457 1229756000644 SH3-like domain; Region: SH3_8; pfam13457 1229756000645 SH3-like domain; Region: SH3_8; pfam13457 1229756000646 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1229756000647 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1229756000648 putative ion selectivity filter; other site 1229756000649 putative pore gating glutamate residue; other site 1229756000650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000651 non-specific DNA binding site [nucleotide binding]; other site 1229756000652 salt bridge; other site 1229756000653 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000654 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1229756000655 active site 1229756000656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1229756000657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756000658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756000659 ABC transporter; Region: ABC_tran_2; pfam12848 1229756000660 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756000661 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1229756000662 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1229756000663 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1229756000664 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1229756000665 BioY family; Region: BioY; pfam02632 1229756000666 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1229756000667 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1229756000668 acyl-activating enzyme (AAE) consensus motif; other site 1229756000669 AMP binding site [chemical binding]; other site 1229756000670 active site 1229756000671 CoA binding site [chemical binding]; other site 1229756000672 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1229756000673 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1229756000674 dimer interface [polypeptide binding]; other site 1229756000675 active site 1229756000676 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1229756000677 AAA domain; Region: AAA_17; pfam13207 1229756000678 alanine racemase; Reviewed; Region: alr; PRK00053 1229756000679 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1229756000680 active site 1229756000681 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1229756000682 dimer interface [polypeptide binding]; other site 1229756000683 substrate binding site [chemical binding]; other site 1229756000684 catalytic residues [active] 1229756000685 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1229756000686 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1229756000687 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1229756000688 putative active site [active] 1229756000689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756000690 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1229756000691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000692 Walker A/P-loop; other site 1229756000693 ATP binding site [chemical binding]; other site 1229756000694 Q-loop/lid; other site 1229756000695 ABC transporter signature motif; other site 1229756000696 Walker B; other site 1229756000697 D-loop; other site 1229756000698 H-loop/switch region; other site 1229756000699 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1229756000700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756000701 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1229756000702 Walker A/P-loop; other site 1229756000703 ATP binding site [chemical binding]; other site 1229756000704 Q-loop/lid; other site 1229756000705 ABC transporter signature motif; other site 1229756000706 Walker B; other site 1229756000707 D-loop; other site 1229756000708 H-loop/switch region; other site 1229756000709 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1229756000710 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1229756000711 Walker A/P-loop; other site 1229756000712 ATP binding site [chemical binding]; other site 1229756000713 Q-loop/lid; other site 1229756000714 ABC transporter signature motif; other site 1229756000715 Walker B; other site 1229756000716 D-loop; other site 1229756000717 H-loop/switch region; other site 1229756000718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756000719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756000720 substrate binding pocket [chemical binding]; other site 1229756000721 membrane-bound complex binding site; other site 1229756000722 hinge residues; other site 1229756000723 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1229756000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000725 dimer interface [polypeptide binding]; other site 1229756000726 conserved gate region; other site 1229756000727 putative PBP binding loops; other site 1229756000728 ABC-ATPase subunit interface; other site 1229756000729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000730 dimer interface [polypeptide binding]; other site 1229756000731 putative PBP binding loops; other site 1229756000732 ABC-ATPase subunit interface; other site 1229756000733 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1229756000734 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1229756000735 peptide binding site [polypeptide binding]; other site 1229756000736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1229756000737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000738 dimer interface [polypeptide binding]; other site 1229756000739 conserved gate region; other site 1229756000740 putative PBP binding loops; other site 1229756000741 ABC-ATPase subunit interface; other site 1229756000742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1229756000743 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1229756000744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756000745 dimer interface [polypeptide binding]; other site 1229756000746 conserved gate region; other site 1229756000747 putative PBP binding loops; other site 1229756000748 ABC-ATPase subunit interface; other site 1229756000749 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1229756000750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1229756000751 Walker A/P-loop; other site 1229756000752 ATP binding site [chemical binding]; other site 1229756000753 Q-loop/lid; other site 1229756000754 ABC transporter signature motif; other site 1229756000755 Walker B; other site 1229756000756 D-loop; other site 1229756000757 H-loop/switch region; other site 1229756000758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1229756000759 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1229756000760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1229756000761 Walker A/P-loop; other site 1229756000762 ATP binding site [chemical binding]; other site 1229756000763 Q-loop/lid; other site 1229756000764 ABC transporter signature motif; other site 1229756000765 Walker B; other site 1229756000766 D-loop; other site 1229756000767 H-loop/switch region; other site 1229756000768 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1229756000769 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1229756000770 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1229756000771 active site 1229756000772 Zn binding site [ion binding]; other site 1229756000773 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1229756000774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000775 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1229756000776 putative substrate translocation pore; other site 1229756000777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000778 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1229756000779 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1229756000780 dimer interface [polypeptide binding]; other site 1229756000781 active site 1229756000782 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1229756000783 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1229756000784 active site 2 [active] 1229756000785 active site 1 [active] 1229756000786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1229756000787 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1229756000788 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756000789 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1229756000790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756000791 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1229756000792 NAD(P) binding site [chemical binding]; other site 1229756000793 active site 1229756000794 putative phosphoketolase; Provisional; Region: PRK05261 1229756000795 XFP N-terminal domain; Region: XFP_N; pfam09364 1229756000796 XFP C-terminal domain; Region: XFP_C; pfam09363 1229756000797 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1229756000798 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1229756000799 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1229756000800 dimerization interface [polypeptide binding]; other site 1229756000801 active site 1229756000802 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1229756000803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756000804 S-adenosylmethionine binding site [chemical binding]; other site 1229756000805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756000806 non-specific DNA binding site [nucleotide binding]; other site 1229756000807 salt bridge; other site 1229756000808 sequence-specific DNA binding site [nucleotide binding]; other site 1229756000809 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1229756000810 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1229756000811 Walker A/P-loop; other site 1229756000812 ATP binding site [chemical binding]; other site 1229756000813 Q-loop/lid; other site 1229756000814 ABC transporter signature motif; other site 1229756000815 Walker B; other site 1229756000816 D-loop; other site 1229756000817 H-loop/switch region; other site 1229756000818 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1229756000819 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1229756000820 FeS assembly protein SufD; Region: sufD; TIGR01981 1229756000821 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1229756000822 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1229756000823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1229756000824 catalytic residue [active] 1229756000825 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1229756000826 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1229756000827 trimerization site [polypeptide binding]; other site 1229756000828 active site 1229756000829 FeS assembly protein SufB; Region: sufB; TIGR01980 1229756000830 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1229756000831 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1229756000832 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1229756000833 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1229756000834 active site 1229756000835 catalytic residues [active] 1229756000836 metal binding site [ion binding]; metal-binding site 1229756000837 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1229756000838 tartrate dehydrogenase; Region: TTC; TIGR02089 1229756000839 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1229756000840 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1229756000841 substrate binding site [chemical binding]; other site 1229756000842 ligand binding site [chemical binding]; other site 1229756000843 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1229756000844 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1229756000845 hypothetical protein; Provisional; Region: PRK14812 1229756000846 substrate binding site [chemical binding]; other site 1229756000847 High-affinity nickel-transport protein; Region: NicO; cl00964 1229756000848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756000849 DNA-binding site [nucleotide binding]; DNA binding site 1229756000850 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1229756000851 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1229756000852 putative dimerization interface [polypeptide binding]; other site 1229756000853 putative ligand binding site [chemical binding]; other site 1229756000854 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1229756000855 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1229756000856 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1229756000857 intersubunit interface [polypeptide binding]; other site 1229756000858 active site 1229756000859 zinc binding site [ion binding]; other site 1229756000860 Na+ binding site [ion binding]; other site 1229756000861 L-arabinose isomerase; Provisional; Region: PRK02929 1229756000862 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1229756000863 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1229756000864 trimer interface [polypeptide binding]; other site 1229756000865 substrate binding site [chemical binding]; other site 1229756000866 Mn binding site [ion binding]; other site 1229756000867 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1229756000868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000869 putative substrate translocation pore; other site 1229756000870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000871 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1229756000872 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1229756000873 putative N- and C-terminal domain interface [polypeptide binding]; other site 1229756000874 putative active site [active] 1229756000875 MgATP binding site [chemical binding]; other site 1229756000876 catalytic site [active] 1229756000877 metal binding site [ion binding]; metal-binding site 1229756000878 putative carbohydrate binding site [chemical binding]; other site 1229756000879 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1229756000880 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1229756000881 intersubunit interface [polypeptide binding]; other site 1229756000882 active site 1229756000883 Zn2+ binding site [ion binding]; other site 1229756000884 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1229756000885 Aspartase; Region: Aspartase; cd01357 1229756000886 active sites [active] 1229756000887 tetramer interface [polypeptide binding]; other site 1229756000888 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1229756000889 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1229756000890 active site 1229756000891 dimer interface [polypeptide binding]; other site 1229756000892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756000893 Coenzyme A binding pocket [chemical binding]; other site 1229756000894 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1229756000895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1229756000896 ABC-ATPase subunit interface; other site 1229756000897 dimer interface [polypeptide binding]; other site 1229756000898 putative PBP binding regions; other site 1229756000899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756000900 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756000901 Walker A/P-loop; other site 1229756000902 ATP binding site [chemical binding]; other site 1229756000903 Q-loop/lid; other site 1229756000904 ABC transporter signature motif; other site 1229756000905 Walker B; other site 1229756000906 D-loop; other site 1229756000907 H-loop/switch region; other site 1229756000908 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1229756000909 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1229756000910 metal binding site [ion binding]; metal-binding site 1229756000911 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1229756000912 trimer interface [polypeptide binding]; other site 1229756000913 active site 1229756000914 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1229756000915 DNA repair protein RadA; Provisional; Region: PRK11823 1229756000916 Walker A motif/ATP binding site; other site 1229756000917 ATP binding site [chemical binding]; other site 1229756000918 Walker B motif; other site 1229756000919 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1229756000920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756000921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756000922 putative substrate translocation pore; other site 1229756000923 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 1229756000924 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1229756000925 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1229756000926 active site 1229756000927 HIGH motif; other site 1229756000928 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1229756000929 active site 1229756000930 KMSKS motif; other site 1229756000931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756000932 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1229756000933 putative NAD(P) binding site [chemical binding]; other site 1229756000934 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1229756000935 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1229756000936 NAD binding site [chemical binding]; other site 1229756000937 substrate binding site [chemical binding]; other site 1229756000938 catalytic Zn binding site [ion binding]; other site 1229756000939 tetramer interface [polypeptide binding]; other site 1229756000940 structural Zn binding site [ion binding]; other site 1229756000941 hypothetical protein; Provisional; Region: PRK13661 1229756000942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756000943 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756000944 Walker A/P-loop; other site 1229756000945 ATP binding site [chemical binding]; other site 1229756000946 Q-loop/lid; other site 1229756000947 ABC transporter signature motif; other site 1229756000948 Walker B; other site 1229756000949 D-loop; other site 1229756000950 H-loop/switch region; other site 1229756000951 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1229756000952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756000953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756000954 Walker A/P-loop; other site 1229756000955 ATP binding site [chemical binding]; other site 1229756000956 Q-loop/lid; other site 1229756000957 ABC transporter signature motif; other site 1229756000958 Walker B; other site 1229756000959 D-loop; other site 1229756000960 H-loop/switch region; other site 1229756000961 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1229756000962 dipeptidase PepV; Reviewed; Region: PRK07318 1229756000963 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1229756000964 active site 1229756000965 metal binding site [ion binding]; metal-binding site 1229756000966 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1229756000967 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1229756000968 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1229756000969 dimer interface [polypeptide binding]; other site 1229756000970 ssDNA binding site [nucleotide binding]; other site 1229756000971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1229756000972 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1229756000973 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1229756000974 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1229756000975 DHH family; Region: DHH; pfam01368 1229756000976 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1229756000977 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1229756000978 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1229756000979 replicative DNA helicase; Region: DnaB; TIGR00665 1229756000980 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1229756000981 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1229756000982 Walker A motif; other site 1229756000983 ATP binding site [chemical binding]; other site 1229756000984 Walker B motif; other site 1229756000985 DNA binding loops [nucleotide binding] 1229756000986 hypothetical protein; Provisional; Region: PRK04860 1229756000987 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1229756000988 putative deacylase active site [active] 1229756000989 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1229756000990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756000991 DNA-binding site [nucleotide binding]; DNA binding site 1229756000992 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1229756000993 putative phosphoketolase; Provisional; Region: PRK05261 1229756000994 XFP N-terminal domain; Region: XFP_N; pfam09364 1229756000995 XFP C-terminal domain; Region: XFP_C; pfam09363 1229756000996 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1229756000997 nudix motif; other site 1229756000998 sugar phosphate phosphatase; Provisional; Region: PRK10513 1229756000999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756001000 active site 1229756001001 motif I; other site 1229756001002 motif II; other site 1229756001003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756001004 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1229756001005 dimer interface [polypeptide binding]; other site 1229756001006 catalytic triad [active] 1229756001007 peroxidatic and resolving cysteines [active] 1229756001008 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1229756001009 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1229756001010 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756001011 active site 1229756001012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756001013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756001014 active site 1229756001015 phosphorylation site [posttranslational modification] 1229756001016 intermolecular recognition site; other site 1229756001017 dimerization interface [polypeptide binding]; other site 1229756001018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756001019 DNA binding site [nucleotide binding] 1229756001020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1229756001021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1229756001022 dimerization interface [polypeptide binding]; other site 1229756001023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1229756001024 putative active site [active] 1229756001025 heme pocket [chemical binding]; other site 1229756001026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1229756001027 dimer interface [polypeptide binding]; other site 1229756001028 phosphorylation site [posttranslational modification] 1229756001029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756001030 ATP binding site [chemical binding]; other site 1229756001031 Mg2+ binding site [ion binding]; other site 1229756001032 G-X-G motif; other site 1229756001033 YycH protein; Region: YycH; pfam07435 1229756001034 YycH protein; Region: YycI; cl02015 1229756001035 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1229756001036 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1229756001037 protein binding site [polypeptide binding]; other site 1229756001038 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1229756001039 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1229756001040 dimer interface [polypeptide binding]; other site 1229756001041 substrate binding site [chemical binding]; other site 1229756001042 ATP binding site [chemical binding]; other site 1229756001043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756001044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756001045 putative substrate translocation pore; other site 1229756001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756001047 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1229756001048 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1229756001049 minor groove reading motif; other site 1229756001050 helix-hairpin-helix signature motif; other site 1229756001051 substrate binding pocket [chemical binding]; other site 1229756001052 active site 1229756001053 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1229756001054 DNA binding and oxoG recognition site [nucleotide binding] 1229756001055 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1229756001056 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1229756001057 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756001058 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1229756001059 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1229756001060 TRAM domain; Region: TRAM; pfam01938 1229756001061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756001062 S-adenosylmethionine binding site [chemical binding]; other site 1229756001063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1229756001064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756001065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1229756001066 Walker A motif; other site 1229756001067 ATP binding site [chemical binding]; other site 1229756001068 Walker B motif; other site 1229756001069 arginine finger; other site 1229756001070 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1229756001071 UvrB/uvrC motif; Region: UVR; pfam02151 1229756001072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756001073 Walker A motif; other site 1229756001074 ATP binding site [chemical binding]; other site 1229756001075 Walker B motif; other site 1229756001076 arginine finger; other site 1229756001077 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1229756001078 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1229756001079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756001080 DNA-binding site [nucleotide binding]; DNA binding site 1229756001081 UTRA domain; Region: UTRA; pfam07702 1229756001082 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1229756001083 HPr interaction site; other site 1229756001084 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1229756001085 active site 1229756001086 phosphorylation site [posttranslational modification] 1229756001087 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1229756001088 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1229756001089 active site turn [active] 1229756001090 phosphorylation site [posttranslational modification] 1229756001091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1229756001092 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1229756001093 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1229756001094 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1229756001095 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1229756001096 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1229756001097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756001098 motif II; other site 1229756001099 Membrane transport protein; Region: Mem_trans; cl09117 1229756001100 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 1229756001101 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1229756001102 putative homodimer interface [polypeptide binding]; other site 1229756001103 putative ligand binding site [chemical binding]; other site 1229756001104 putative NAD binding site [chemical binding]; other site 1229756001105 catalytic site [active] 1229756001106 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1229756001107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756001108 ATP binding site [chemical binding]; other site 1229756001109 Mg2+ binding site [ion binding]; other site 1229756001110 G-X-G motif; other site 1229756001111 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1229756001112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756001113 active site 1229756001114 phosphorylation site [posttranslational modification] 1229756001115 intermolecular recognition site; other site 1229756001116 dimerization interface [polypeptide binding]; other site 1229756001117 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1229756001118 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1229756001119 nudix motif; other site 1229756001120 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1229756001121 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1229756001122 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1229756001123 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1229756001124 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1229756001125 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1229756001126 active site 1229756001127 HIGH motif; other site 1229756001128 dimer interface [polypeptide binding]; other site 1229756001129 KMSKS motif; other site 1229756001130 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1229756001131 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1229756001132 active site 1229756001133 lysine transporter; Provisional; Region: PRK10836 1229756001134 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1229756001135 rod shape-determining protein MreB; Provisional; Region: PRK13930 1229756001136 MreB and similar proteins; Region: MreB_like; cd10225 1229756001137 nucleotide binding site [chemical binding]; other site 1229756001138 Mg binding site [ion binding]; other site 1229756001139 putative protofilament interaction site [polypeptide binding]; other site 1229756001140 RodZ interaction site [polypeptide binding]; other site 1229756001141 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1229756001142 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1229756001143 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1229756001144 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1229756001145 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1229756001146 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1229756001147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756001148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756001149 non-specific DNA binding site [nucleotide binding]; other site 1229756001150 salt bridge; other site 1229756001151 sequence-specific DNA binding site [nucleotide binding]; other site 1229756001152 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1229756001153 Ligand Binding Site [chemical binding]; other site 1229756001154 recombination factor protein RarA; Reviewed; Region: PRK13342 1229756001155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756001156 Walker A motif; other site 1229756001157 ATP binding site [chemical binding]; other site 1229756001158 Walker B motif; other site 1229756001159 arginine finger; other site 1229756001160 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1229756001161 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1229756001162 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1229756001163 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1229756001164 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756001165 RNA binding surface [nucleotide binding]; other site 1229756001166 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1229756001167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1229756001168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1229756001169 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1229756001170 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1229756001171 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1229756001172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756001173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756001174 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1229756001175 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1229756001176 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1229756001177 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1229756001178 putative homodimer interface [polypeptide binding]; other site 1229756001179 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1229756001180 heterodimer interface [polypeptide binding]; other site 1229756001181 homodimer interface [polypeptide binding]; other site 1229756001182 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1229756001183 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1229756001184 23S rRNA interface [nucleotide binding]; other site 1229756001185 L7/L12 interface [polypeptide binding]; other site 1229756001186 putative thiostrepton binding site; other site 1229756001187 L25 interface [polypeptide binding]; other site 1229756001188 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1229756001189 mRNA/rRNA interface [nucleotide binding]; other site 1229756001190 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1229756001191 23S rRNA interface [nucleotide binding]; other site 1229756001192 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1229756001193 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1229756001194 peripheral dimer interface [polypeptide binding]; other site 1229756001195 core dimer interface [polypeptide binding]; other site 1229756001196 L10 interface [polypeptide binding]; other site 1229756001197 L11 interface [polypeptide binding]; other site 1229756001198 putative EF-Tu interaction site [polypeptide binding]; other site 1229756001199 putative EF-G interaction site [polypeptide binding]; other site 1229756001200 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1229756001201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756001202 S-adenosylmethionine binding site [chemical binding]; other site 1229756001203 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1229756001204 nucleoside/Zn binding site; other site 1229756001205 dimer interface [polypeptide binding]; other site 1229756001206 catalytic motif [active] 1229756001207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756001208 Zn2+ binding site [ion binding]; other site 1229756001209 Mg2+ binding site [ion binding]; other site 1229756001210 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1229756001211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756001212 Walker A motif; other site 1229756001213 ATP binding site [chemical binding]; other site 1229756001214 Walker B motif; other site 1229756001215 recombination protein RecR; Reviewed; Region: recR; PRK00076 1229756001216 RecR protein; Region: RecR; pfam02132 1229756001217 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1229756001218 putative active site [active] 1229756001219 putative metal-binding site [ion binding]; other site 1229756001220 tetramer interface [polypeptide binding]; other site 1229756001221 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1229756001222 thymidylate kinase; Validated; Region: tmk; PRK00698 1229756001223 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1229756001224 TMP-binding site; other site 1229756001225 ATP-binding site [chemical binding]; other site 1229756001226 Protein of unknown function (DUF970); Region: DUF970; cl17525 1229756001227 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1229756001228 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1229756001229 Predicted methyltransferases [General function prediction only]; Region: COG0313 1229756001230 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1229756001231 putative SAM binding site [chemical binding]; other site 1229756001232 putative homodimer interface [polypeptide binding]; other site 1229756001233 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1229756001234 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1229756001235 active site 1229756001236 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1229756001237 active site 2 [active] 1229756001238 active site 1 [active] 1229756001239 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1229756001240 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1229756001241 NAD binding site [chemical binding]; other site 1229756001242 homodimer interface [polypeptide binding]; other site 1229756001243 active site 1229756001244 substrate binding site [chemical binding]; other site 1229756001245 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1229756001246 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1229756001247 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1229756001248 Substrate-binding site [chemical binding]; other site 1229756001249 Substrate specificity [chemical binding]; other site 1229756001250 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1229756001251 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1229756001252 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1229756001253 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1229756001254 active site 1229756001255 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1229756001256 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1229756001257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1229756001258 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1229756001259 ATP binding site [chemical binding]; other site 1229756001260 putative Mg++ binding site [ion binding]; other site 1229756001261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756001262 nucleotide binding region [chemical binding]; other site 1229756001263 ATP-binding site [chemical binding]; other site 1229756001264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756001265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756001266 active site 1229756001267 phosphorylation site [posttranslational modification] 1229756001268 intermolecular recognition site; other site 1229756001269 dimerization interface [polypeptide binding]; other site 1229756001270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756001271 DNA binding site [nucleotide binding] 1229756001272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1229756001273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1229756001274 dimer interface [polypeptide binding]; other site 1229756001275 phosphorylation site [posttranslational modification] 1229756001276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756001277 ATP binding site [chemical binding]; other site 1229756001278 Mg2+ binding site [ion binding]; other site 1229756001279 G-X-G motif; other site 1229756001280 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1229756001281 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1229756001282 catalytic residues [active] 1229756001283 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1229756001284 conserved cys residue [active] 1229756001285 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1229756001286 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1229756001287 homodimer interface [polypeptide binding]; other site 1229756001288 substrate-cofactor binding pocket; other site 1229756001289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756001290 catalytic residue [active] 1229756001291 cystathionine beta-lyase; Provisional; Region: PRK08064 1229756001292 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1229756001293 homodimer interface [polypeptide binding]; other site 1229756001294 substrate-cofactor binding pocket; other site 1229756001295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756001296 catalytic residue [active] 1229756001297 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1229756001298 substrate binding site [chemical binding]; other site 1229756001299 THF binding site; other site 1229756001300 zinc-binding site [ion binding]; other site 1229756001301 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1229756001302 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1229756001303 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1229756001304 peptide binding site [polypeptide binding]; other site 1229756001305 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1229756001306 Peptidase C26; Region: Peptidase_C26; pfam07722 1229756001307 catalytic triad [active] 1229756001308 Amino acid permease; Region: AA_permease_2; pfam13520 1229756001309 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1229756001310 catalytic triad [active] 1229756001311 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1229756001312 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756001313 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1229756001314 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1229756001315 NlpC/P60 family; Region: NLPC_P60; cl17555 1229756001316 thymidine kinase; Provisional; Region: PRK04296 1229756001317 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1229756001318 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1229756001319 RF-1 domain; Region: RF-1; pfam00472 1229756001320 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1229756001321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756001322 S-adenosylmethionine binding site [chemical binding]; other site 1229756001323 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1229756001324 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1229756001325 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1229756001326 dimerization domain swap beta strand [polypeptide binding]; other site 1229756001327 regulatory protein interface [polypeptide binding]; other site 1229756001328 active site 1229756001329 regulatory phosphorylation site [posttranslational modification]; other site 1229756001330 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1229756001331 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1229756001332 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1229756001333 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1229756001334 potential frameshift: common BLAST hit: gi|300172701|ref|YP_003771866.1| RNA polymerase ECF sigma factor 1229756001335 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1229756001336 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1229756001337 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1229756001338 Glycoprotease family; Region: Peptidase_M22; pfam00814 1229756001339 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1229756001340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756001341 Coenzyme A binding pocket [chemical binding]; other site 1229756001342 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1229756001343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756001344 Coenzyme A binding pocket [chemical binding]; other site 1229756001345 UGMP family protein; Validated; Region: PRK09604 1229756001346 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1229756001347 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1229756001348 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1229756001349 CoA binding domain; Region: CoA_binding; pfam02629 1229756001350 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1229756001351 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1229756001352 Predicted membrane protein [Function unknown]; Region: COG2246 1229756001353 GtrA-like protein; Region: GtrA; pfam04138 1229756001354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1229756001355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756001356 active site 1229756001357 motif I; other site 1229756001358 motif II; other site 1229756001359 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1229756001360 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1229756001361 dimer interface [polypeptide binding]; other site 1229756001362 FMN binding site [chemical binding]; other site 1229756001363 NADPH bind site [chemical binding]; other site 1229756001364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756001365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756001366 non-specific DNA binding site [nucleotide binding]; other site 1229756001367 salt bridge; other site 1229756001368 sequence-specific DNA binding site [nucleotide binding]; other site 1229756001369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756001370 non-specific DNA binding site [nucleotide binding]; other site 1229756001371 salt bridge; other site 1229756001372 sequence-specific DNA binding site [nucleotide binding]; other site 1229756001373 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1229756001374 Ligand binding site; other site 1229756001375 Putative Catalytic site; other site 1229756001376 DXD motif; other site 1229756001377 GtrA-like protein; Region: GtrA; pfam04138 1229756001378 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1229756001379 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1229756001380 DXD motif; other site 1229756001381 Cellulose synthase-like protein; Region: PLN02893 1229756001382 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 1229756001383 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1229756001384 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1229756001385 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1229756001386 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1229756001387 active pocket/dimerization site; other site 1229756001388 active site 1229756001389 phosphorylation site [posttranslational modification] 1229756001390 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1229756001391 active site 1229756001392 phosphorylation site [posttranslational modification] 1229756001393 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1229756001394 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1229756001395 Domain of unknown function (DUF956); Region: DUF956; cl01917 1229756001396 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1229756001397 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756001398 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756001399 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1229756001400 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1229756001401 oligomerisation interface [polypeptide binding]; other site 1229756001402 mobile loop; other site 1229756001403 roof hairpin; other site 1229756001404 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1229756001405 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1229756001406 ring oligomerisation interface [polypeptide binding]; other site 1229756001407 ATP/Mg binding site [chemical binding]; other site 1229756001408 stacking interactions; other site 1229756001409 hinge regions; other site 1229756001410 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1229756001411 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1229756001412 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1229756001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756001414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756001415 putative substrate translocation pore; other site 1229756001416 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1229756001417 trimer interface [polypeptide binding]; other site 1229756001418 active site 1229756001419 G bulge; other site 1229756001420 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1229756001421 UbiA prenyltransferase family; Region: UbiA; pfam01040 1229756001422 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1229756001423 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1229756001424 putative active site [active] 1229756001425 catalytic residue [active] 1229756001426 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1229756001427 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1229756001428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756001429 ATP binding site [chemical binding]; other site 1229756001430 putative Mg++ binding site [ion binding]; other site 1229756001431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756001432 nucleotide binding region [chemical binding]; other site 1229756001433 ATP-binding site [chemical binding]; other site 1229756001434 TRCF domain; Region: TRCF; pfam03461 1229756001435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756001436 RNA binding surface [nucleotide binding]; other site 1229756001437 Septum formation initiator; Region: DivIC; pfam04977 1229756001438 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1229756001439 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1229756001440 Ligand Binding Site [chemical binding]; other site 1229756001441 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1229756001442 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756001443 active site 1229756001444 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1229756001445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756001446 Walker A motif; other site 1229756001447 ATP binding site [chemical binding]; other site 1229756001448 Walker B motif; other site 1229756001449 arginine finger; other site 1229756001450 Peptidase family M41; Region: Peptidase_M41; pfam01434 1229756001451 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1229756001452 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1229756001453 dimerization interface [polypeptide binding]; other site 1229756001454 domain crossover interface; other site 1229756001455 redox-dependent activation switch; other site 1229756001456 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1229756001457 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1229756001458 dimer interface [polypeptide binding]; other site 1229756001459 putative anticodon binding site; other site 1229756001460 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1229756001461 motif 1; other site 1229756001462 active site 1229756001463 motif 2; other site 1229756001464 motif 3; other site 1229756001465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756001466 putative substrate translocation pore; other site 1229756001467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756001468 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1229756001469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1229756001470 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1229756001471 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1229756001472 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756001473 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756001474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756001475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756001476 Walker A/P-loop; other site 1229756001477 ATP binding site [chemical binding]; other site 1229756001478 Q-loop/lid; other site 1229756001479 ABC transporter signature motif; other site 1229756001480 Walker B; other site 1229756001481 D-loop; other site 1229756001482 H-loop/switch region; other site 1229756001483 FtsX-like permease family; Region: FtsX; pfam02687 1229756001484 potential frameshift: common BLAST hit: gi|300172748|ref|YP_003771913.1| putative substrate-binding protein 1229756001485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756001486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756001487 sequence-specific DNA binding site [nucleotide binding]; other site 1229756001488 salt bridge; other site 1229756001489 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1229756001490 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1229756001491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1229756001492 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756001493 Walker A/P-loop; other site 1229756001494 ATP binding site [chemical binding]; other site 1229756001495 Q-loop/lid; other site 1229756001496 ABC transporter signature motif; other site 1229756001497 Walker B; other site 1229756001498 D-loop; other site 1229756001499 H-loop/switch region; other site 1229756001500 LytTr DNA-binding domain; Region: LytTR; smart00850 1229756001501 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1229756001502 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1229756001503 active site 1229756001504 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1229756001505 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1229756001506 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1229756001507 active site 1229756001508 putative interdomain interaction site [polypeptide binding]; other site 1229756001509 putative metal-binding site [ion binding]; other site 1229756001510 putative nucleotide binding site [chemical binding]; other site 1229756001511 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1229756001512 domain I; other site 1229756001513 DNA binding groove [nucleotide binding] 1229756001514 phosphate binding site [ion binding]; other site 1229756001515 domain II; other site 1229756001516 domain III; other site 1229756001517 nucleotide binding site [chemical binding]; other site 1229756001518 catalytic site [active] 1229756001519 domain IV; other site 1229756001520 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756001521 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756001522 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1229756001523 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1229756001524 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1229756001525 competence damage-inducible protein A; Provisional; Region: PRK00549 1229756001526 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1229756001527 putative MPT binding site; other site 1229756001528 Competence-damaged protein; Region: CinA; cl00666 1229756001529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756001530 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1229756001531 NAD(P) binding site [chemical binding]; other site 1229756001532 active site 1229756001533 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1229756001534 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1229756001535 dimer interface [polypeptide binding]; other site 1229756001536 active site 1229756001537 metal binding site [ion binding]; metal-binding site 1229756001538 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1229756001539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756001540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756001541 Walker A/P-loop; other site 1229756001542 ATP binding site [chemical binding]; other site 1229756001543 Q-loop/lid; other site 1229756001544 ABC transporter signature motif; other site 1229756001545 Walker B; other site 1229756001546 D-loop; other site 1229756001547 H-loop/switch region; other site 1229756001548 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1229756001549 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756001550 Walker A/P-loop; other site 1229756001551 ATP binding site [chemical binding]; other site 1229756001552 Q-loop/lid; other site 1229756001553 ABC transporter signature motif; other site 1229756001554 Walker B; other site 1229756001555 D-loop; other site 1229756001556 H-loop/switch region; other site 1229756001557 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1229756001558 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1229756001559 RibD C-terminal domain; Region: RibD_C; cl17279 1229756001560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1229756001561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1229756001562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1229756001563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1229756001564 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1229756001565 tetramer interfaces [polypeptide binding]; other site 1229756001566 binuclear metal-binding site [ion binding]; other site 1229756001567 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1229756001568 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1229756001569 active site 1229756001570 dimer interface [polypeptide binding]; other site 1229756001571 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1229756001572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756001573 DNA-binding site [nucleotide binding]; DNA binding site 1229756001574 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1229756001575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756001576 dimer interface [polypeptide binding]; other site 1229756001577 conserved gate region; other site 1229756001578 ABC-ATPase subunit interface; other site 1229756001579 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1229756001580 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1229756001581 Walker A/P-loop; other site 1229756001582 ATP binding site [chemical binding]; other site 1229756001583 Q-loop/lid; other site 1229756001584 ABC transporter signature motif; other site 1229756001585 Walker B; other site 1229756001586 D-loop; other site 1229756001587 H-loop/switch region; other site 1229756001588 NIL domain; Region: NIL; pfam09383 1229756001589 hypothetical protein; Provisional; Region: PRK06446 1229756001590 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1229756001591 metal binding site [ion binding]; metal-binding site 1229756001592 dimer interface [polypeptide binding]; other site 1229756001593 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1229756001594 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1229756001595 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1229756001596 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1229756001597 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1229756001598 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1229756001599 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1229756001600 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1229756001601 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1229756001602 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1229756001603 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1229756001604 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1229756001605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1229756001606 metal binding site 2 [ion binding]; metal-binding site 1229756001607 putative DNA binding helix; other site 1229756001608 metal binding site 1 [ion binding]; metal-binding site 1229756001609 dimer interface [polypeptide binding]; other site 1229756001610 structural Zn2+ binding site [ion binding]; other site 1229756001611 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1229756001612 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1229756001613 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1229756001614 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1229756001615 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1229756001616 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1229756001617 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1229756001618 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1229756001619 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1229756001620 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1229756001621 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1229756001622 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 1229756001623 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 1229756001624 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1229756001625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1229756001626 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1229756001627 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1229756001628 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1229756001629 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1229756001630 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1229756001631 elongation factor P; Validated; Region: PRK00529 1229756001632 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1229756001633 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1229756001634 RNA binding site [nucleotide binding]; other site 1229756001635 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1229756001636 RNA binding site [nucleotide binding]; other site 1229756001637 Asp23 family; Region: Asp23; pfam03780 1229756001638 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1229756001639 putative RNA binding site [nucleotide binding]; other site 1229756001640 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1229756001641 active site 1229756001642 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1229756001643 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1229756001644 putative active site [active] 1229756001645 putative metal binding site [ion binding]; other site 1229756001646 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1229756001647 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1229756001648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756001649 S-adenosylmethionine binding site [chemical binding]; other site 1229756001650 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1229756001651 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1229756001652 intersubunit interface [polypeptide binding]; other site 1229756001653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1229756001654 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1229756001655 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1229756001656 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1229756001657 pur operon repressor; Provisional; Region: PRK09213 1229756001658 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1229756001659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756001660 active site 1229756001661 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1229756001662 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1229756001663 Substrate binding site; other site 1229756001664 Mg++ binding site; other site 1229756001665 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1229756001666 active site 1229756001667 substrate binding site [chemical binding]; other site 1229756001668 CoA binding site [chemical binding]; other site 1229756001669 SLBB domain; Region: SLBB; pfam10531 1229756001670 comEA protein; Region: comE; TIGR01259 1229756001671 Helix-hairpin-helix motif; Region: HHH; pfam00633 1229756001672 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1229756001673 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1229756001674 Competence protein; Region: Competence; pfam03772 1229756001675 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1229756001676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1229756001677 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1229756001678 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1229756001679 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1229756001680 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1229756001681 16S/18S rRNA binding site [nucleotide binding]; other site 1229756001682 S13e-L30e interaction site [polypeptide binding]; other site 1229756001683 25S rRNA binding site [nucleotide binding]; other site 1229756001684 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1229756001685 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1229756001686 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1229756001687 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1229756001688 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1229756001689 GatB domain; Region: GatB_Yqey; smart00845 1229756001690 putative lipid kinase; Reviewed; Region: PRK13055 1229756001691 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1229756001692 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1229756001693 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1229756001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756001695 S-adenosylmethionine binding site [chemical binding]; other site 1229756001696 CTP synthetase; Validated; Region: pyrG; PRK05380 1229756001697 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1229756001698 Catalytic site [active] 1229756001699 active site 1229756001700 UTP binding site [chemical binding]; other site 1229756001701 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1229756001702 active site 1229756001703 putative oxyanion hole; other site 1229756001704 catalytic triad [active] 1229756001705 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1229756001706 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1229756001707 GIY-YIG motif/motif A; other site 1229756001708 active site 1229756001709 catalytic site [active] 1229756001710 putative DNA binding site [nucleotide binding]; other site 1229756001711 metal binding site [ion binding]; metal-binding site 1229756001712 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1229756001713 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1229756001714 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1229756001715 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1229756001716 Walker A/P-loop; other site 1229756001717 ATP binding site [chemical binding]; other site 1229756001718 Q-loop/lid; other site 1229756001719 ABC transporter signature motif; other site 1229756001720 Walker B; other site 1229756001721 D-loop; other site 1229756001722 H-loop/switch region; other site 1229756001723 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1229756001724 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1229756001725 GTP1/OBG; Region: GTP1_OBG; pfam01018 1229756001726 Obg GTPase; Region: Obg; cd01898 1229756001727 G1 box; other site 1229756001728 GTP/Mg2+ binding site [chemical binding]; other site 1229756001729 Switch I region; other site 1229756001730 G2 box; other site 1229756001731 G3 box; other site 1229756001732 Switch II region; other site 1229756001733 G4 box; other site 1229756001734 G5 box; other site 1229756001735 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1229756001736 acetolactate synthase; Reviewed; Region: PRK08617 1229756001737 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1229756001738 PYR/PP interface [polypeptide binding]; other site 1229756001739 dimer interface [polypeptide binding]; other site 1229756001740 TPP binding site [chemical binding]; other site 1229756001741 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1229756001742 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1229756001743 TPP-binding site [chemical binding]; other site 1229756001744 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756001745 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1229756001746 active site 1229756001747 catalytic site [active] 1229756001748 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1229756001749 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1229756001750 effector binding site; other site 1229756001751 active site 1229756001752 Zn binding site [ion binding]; other site 1229756001753 glycine loop; other site 1229756001754 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1229756001755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1229756001756 FeS/SAM binding site; other site 1229756001757 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1229756001758 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1229756001759 Walker A/P-loop; other site 1229756001760 ATP binding site [chemical binding]; other site 1229756001761 Q-loop/lid; other site 1229756001762 ABC transporter signature motif; other site 1229756001763 Walker B; other site 1229756001764 D-loop; other site 1229756001765 H-loop/switch region; other site 1229756001766 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1229756001767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1229756001768 active site 1229756001769 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1229756001770 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1229756001771 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1229756001772 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1229756001773 Probable Catalytic site; other site 1229756001774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1229756001775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1229756001776 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1229756001777 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1229756001778 SecY translocase; Region: SecY; pfam00344 1229756001779 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1229756001780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1229756001781 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1229756001782 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1229756001783 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 1229756001784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1229756001785 ATP binding site [chemical binding]; other site 1229756001786 putative Mg++ binding site [ion binding]; other site 1229756001787 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1229756001788 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1229756001789 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1229756001790 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1229756001791 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1229756001792 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1229756001793 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1229756001794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1229756001795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1229756001796 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1229756001797 active site 1229756001798 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1229756001799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756001800 Coenzyme A binding pocket [chemical binding]; other site 1229756001801 thymidylate synthase; Region: thym_sym; TIGR03284 1229756001802 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1229756001803 dimerization interface [polypeptide binding]; other site 1229756001804 active site 1229756001805 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1229756001806 catalytic motif [active] 1229756001807 Zn binding site [ion binding]; other site 1229756001808 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1229756001809 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1229756001810 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1229756001811 homodimer interface [polypeptide binding]; other site 1229756001812 NADP binding site [chemical binding]; other site 1229756001813 substrate binding site [chemical binding]; other site 1229756001814 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1229756001815 CHY zinc finger; Region: zf-CHY; pfam05495 1229756001816 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1229756001817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1229756001818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756001819 DNA-binding site [nucleotide binding]; DNA binding site 1229756001820 TrkA-C domain; Region: TrkA_C; pfam02080 1229756001821 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1229756001822 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1229756001823 Walker A/P-loop; other site 1229756001824 ATP binding site [chemical binding]; other site 1229756001825 Q-loop/lid; other site 1229756001826 ABC transporter signature motif; other site 1229756001827 Walker B; other site 1229756001828 D-loop; other site 1229756001829 H-loop/switch region; other site 1229756001830 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1229756001831 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1229756001832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756001833 dimer interface [polypeptide binding]; other site 1229756001834 conserved gate region; other site 1229756001835 putative PBP binding loops; other site 1229756001836 ABC-ATPase subunit interface; other site 1229756001837 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1229756001838 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1229756001839 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1229756001840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756001841 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1229756001842 HPr interaction site; other site 1229756001843 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1229756001844 active site 1229756001845 phosphorylation site [posttranslational modification] 1229756001846 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756001847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756001848 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756001849 galactokinase; Provisional; Region: PRK05322 1229756001850 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1229756001851 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1229756001852 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1229756001853 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1229756001854 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1229756001855 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1229756001856 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1229756001857 active site 1229756001858 catalytic residues [active] 1229756001859 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1229756001860 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1229756001861 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1229756001862 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1229756001863 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1229756001864 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1229756001865 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1229756001866 active site 1229756001867 catalytic tetrad [active] 1229756001868 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1229756001869 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1229756001870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756001871 Walker A/P-loop; other site 1229756001872 ATP binding site [chemical binding]; other site 1229756001873 Q-loop/lid; other site 1229756001874 ABC transporter signature motif; other site 1229756001875 Walker B; other site 1229756001876 D-loop; other site 1229756001877 H-loop/switch region; other site 1229756001878 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1229756001879 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756001880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756001881 non-specific DNA binding site [nucleotide binding]; other site 1229756001882 salt bridge; other site 1229756001883 sequence-specific DNA binding site [nucleotide binding]; other site 1229756001884 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1229756001885 putative deacylase active site [active] 1229756001886 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1229756001887 VanW like protein; Region: VanW; pfam04294 1229756001888 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1229756001889 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1229756001890 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1229756001891 NAD(P) binding site [chemical binding]; other site 1229756001892 catalytic residues [active] 1229756001893 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1229756001894 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1229756001895 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1229756001896 generic binding surface II; other site 1229756001897 ssDNA binding site; other site 1229756001898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756001899 ATP binding site [chemical binding]; other site 1229756001900 putative Mg++ binding site [ion binding]; other site 1229756001901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756001902 nucleotide binding region [chemical binding]; other site 1229756001903 ATP-binding site [chemical binding]; other site 1229756001904 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1229756001905 MutS domain I; Region: MutS_I; pfam01624 1229756001906 MutS domain II; Region: MutS_II; pfam05188 1229756001907 MutS domain III; Region: MutS_III; pfam05192 1229756001908 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1229756001909 Walker A/P-loop; other site 1229756001910 ATP binding site [chemical binding]; other site 1229756001911 Q-loop/lid; other site 1229756001912 ABC transporter signature motif; other site 1229756001913 Walker B; other site 1229756001914 D-loop; other site 1229756001915 H-loop/switch region; other site 1229756001916 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1229756001917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756001918 ATP binding site [chemical binding]; other site 1229756001919 Mg2+ binding site [ion binding]; other site 1229756001920 G-X-G motif; other site 1229756001921 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1229756001922 ATP binding site [chemical binding]; other site 1229756001923 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1229756001924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1229756001925 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1229756001926 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1229756001927 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1229756001928 active site 1229756001929 multimer interface [polypeptide binding]; other site 1229756001930 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1229756001931 FAD binding domain; Region: FAD_binding_4; pfam01565 1229756001932 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1229756001933 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1229756001934 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1229756001935 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1229756001936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1229756001937 YbbR-like protein; Region: YbbR; pfam07949 1229756001938 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1229756001939 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1229756001940 active site 1229756001941 substrate binding site [chemical binding]; other site 1229756001942 metal binding site [ion binding]; metal-binding site 1229756001943 ribonuclease III; Reviewed; Region: rnc; PRK00102 1229756001944 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1229756001945 dimerization interface [polypeptide binding]; other site 1229756001946 active site 1229756001947 metal binding site [ion binding]; metal-binding site 1229756001948 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1229756001949 dsRNA binding site [nucleotide binding]; other site 1229756001950 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1229756001951 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1229756001952 Walker A/P-loop; other site 1229756001953 ATP binding site [chemical binding]; other site 1229756001954 Q-loop/lid; other site 1229756001955 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1229756001956 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1229756001957 ABC transporter signature motif; other site 1229756001958 Walker B; other site 1229756001959 D-loop; other site 1229756001960 H-loop/switch region; other site 1229756001961 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1229756001962 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1229756001963 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1229756001964 P loop; other site 1229756001965 GTP binding site [chemical binding]; other site 1229756001966 putative DNA-binding protein; Validated; Region: PRK00118 1229756001967 signal recognition particle protein; Provisional; Region: PRK10867 1229756001968 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1229756001969 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1229756001970 P loop; other site 1229756001971 GTP binding site [chemical binding]; other site 1229756001972 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1229756001973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1229756001974 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1229756001975 active site 1229756001976 motif I; other site 1229756001977 motif II; other site 1229756001978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756001979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1229756001980 Predicted flavoprotein [General function prediction only]; Region: COG0431 1229756001981 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1229756001982 beta-galactosidase; Region: BGL; TIGR03356 1229756001983 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 1229756001984 active site 1229756001985 P-loop; other site 1229756001986 phosphorylation site [posttranslational modification] 1229756001987 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1229756001988 HTH domain; Region: HTH_11; pfam08279 1229756001989 Mga helix-turn-helix domain; Region: Mga; pfam05043 1229756001990 PRD domain; Region: PRD; pfam00874 1229756001991 PRD domain; Region: PRD; pfam00874 1229756001992 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1229756001993 active site 1229756001994 P-loop; other site 1229756001995 phosphorylation site [posttranslational modification] 1229756001996 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1229756001997 active site 1229756001998 phosphorylation site [posttranslational modification] 1229756001999 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1229756002000 methionine cluster; other site 1229756002001 active site 1229756002002 phosphorylation site [posttranslational modification] 1229756002003 metal binding site [ion binding]; metal-binding site 1229756002004 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1229756002005 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1229756002006 histidinol-phosphatase; Reviewed; Region: PRK08123 1229756002007 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1229756002008 active site 1229756002009 dimer interface [polypeptide binding]; other site 1229756002010 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1229756002011 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1229756002012 dimer interface [polypeptide binding]; other site 1229756002013 motif 1; other site 1229756002014 active site 1229756002015 motif 2; other site 1229756002016 motif 3; other site 1229756002017 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1229756002018 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1229756002019 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1229756002020 histidinol dehydrogenase; Region: hisD; TIGR00069 1229756002021 NAD binding site [chemical binding]; other site 1229756002022 dimerization interface [polypeptide binding]; other site 1229756002023 product binding site; other site 1229756002024 substrate binding site [chemical binding]; other site 1229756002025 zinc binding site [ion binding]; other site 1229756002026 catalytic residues [active] 1229756002027 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1229756002028 putative active site pocket [active] 1229756002029 4-fold oligomerization interface [polypeptide binding]; other site 1229756002030 metal binding residues [ion binding]; metal-binding site 1229756002031 3-fold/trimer interface [polypeptide binding]; other site 1229756002032 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1229756002033 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1229756002034 putative active site [active] 1229756002035 oxyanion strand; other site 1229756002036 catalytic triad [active] 1229756002037 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1229756002038 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1229756002039 catalytic residues [active] 1229756002040 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1229756002041 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1229756002042 substrate binding site [chemical binding]; other site 1229756002043 glutamase interaction surface [polypeptide binding]; other site 1229756002044 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1229756002045 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1229756002046 metal binding site [ion binding]; metal-binding site 1229756002047 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1229756002048 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756002049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756002050 homodimer interface [polypeptide binding]; other site 1229756002051 catalytic residue [active] 1229756002052 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1229756002053 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1229756002054 GDP-binding site [chemical binding]; other site 1229756002055 ACT binding site; other site 1229756002056 IMP binding site; other site 1229756002057 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1229756002058 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1229756002059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1229756002060 Walker A motif; other site 1229756002061 ATP binding site [chemical binding]; other site 1229756002062 Walker B motif; other site 1229756002063 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1229756002064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756002065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1229756002066 Walker A motif; other site 1229756002067 ATP binding site [chemical binding]; other site 1229756002068 Walker B motif; other site 1229756002069 arginine finger; other site 1229756002070 UvrB/uvrC motif; Region: UVR; pfam02151 1229756002071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756002072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1229756002073 Walker A motif; other site 1229756002074 ATP binding site [chemical binding]; other site 1229756002075 Walker B motif; other site 1229756002076 arginine finger; other site 1229756002077 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1229756002078 rod shape-determining protein MreB; Provisional; Region: PRK13927 1229756002079 MreB and similar proteins; Region: MreB_like; cd10225 1229756002080 nucleotide binding site [chemical binding]; other site 1229756002081 Mg binding site [ion binding]; other site 1229756002082 putative protofilament interaction site [polypeptide binding]; other site 1229756002083 RodZ interaction site [polypeptide binding]; other site 1229756002084 rod shape-determining protein MreC; Provisional; Region: PRK13922 1229756002085 rod shape-determining protein MreC; Region: MreC; pfam04085 1229756002086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756002087 dimer interface [polypeptide binding]; other site 1229756002088 conserved gate region; other site 1229756002089 putative PBP binding loops; other site 1229756002090 ABC-ATPase subunit interface; other site 1229756002091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756002093 Walker A/P-loop; other site 1229756002094 ATP binding site [chemical binding]; other site 1229756002095 Q-loop/lid; other site 1229756002096 ABC transporter signature motif; other site 1229756002097 Walker B; other site 1229756002098 D-loop; other site 1229756002099 H-loop/switch region; other site 1229756002100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756002101 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756002102 substrate binding pocket [chemical binding]; other site 1229756002103 membrane-bound complex binding site; other site 1229756002104 hinge residues; other site 1229756002105 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1229756002106 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1229756002107 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1229756002108 putative active site [active] 1229756002109 catalytic site [active] 1229756002110 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1229756002111 putative active site [active] 1229756002112 catalytic site [active] 1229756002113 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1229756002114 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1229756002115 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1229756002116 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1229756002117 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1229756002118 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1229756002119 Helix-turn-helix domain; Region: HTH_25; pfam13413 1229756002120 non-specific DNA binding site [nucleotide binding]; other site 1229756002121 salt bridge; other site 1229756002122 sequence-specific DNA binding site [nucleotide binding]; other site 1229756002123 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1229756002124 recombinase A; Provisional; Region: recA; PRK09354 1229756002125 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1229756002126 hexamer interface [polypeptide binding]; other site 1229756002127 Walker A motif; other site 1229756002128 ATP binding site [chemical binding]; other site 1229756002129 Walker B motif; other site 1229756002130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756002131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756002132 active site 1229756002133 phosphorylation site [posttranslational modification] 1229756002134 intermolecular recognition site; other site 1229756002135 dimerization interface [polypeptide binding]; other site 1229756002136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756002137 DNA binding site [nucleotide binding] 1229756002138 PBP superfamily domain; Region: PBP_like_2; cl17296 1229756002139 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1229756002140 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1229756002141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1229756002142 dimer interface [polypeptide binding]; other site 1229756002143 phosphorylation site [posttranslational modification] 1229756002144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756002145 ATP binding site [chemical binding]; other site 1229756002146 Mg2+ binding site [ion binding]; other site 1229756002147 G-X-G motif; other site 1229756002148 PBP superfamily domain; Region: PBP_like_2; cl17296 1229756002149 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1229756002150 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1229756002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756002152 dimer interface [polypeptide binding]; other site 1229756002153 conserved gate region; other site 1229756002154 putative PBP binding loops; other site 1229756002155 ABC-ATPase subunit interface; other site 1229756002156 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1229756002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756002158 dimer interface [polypeptide binding]; other site 1229756002159 conserved gate region; other site 1229756002160 putative PBP binding loops; other site 1229756002161 ABC-ATPase subunit interface; other site 1229756002162 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1229756002163 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1229756002164 Walker A/P-loop; other site 1229756002165 ATP binding site [chemical binding]; other site 1229756002166 Q-loop/lid; other site 1229756002167 ABC transporter signature motif; other site 1229756002168 Walker B; other site 1229756002169 D-loop; other site 1229756002170 H-loop/switch region; other site 1229756002171 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1229756002172 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1229756002173 Walker A/P-loop; other site 1229756002174 ATP binding site [chemical binding]; other site 1229756002175 Q-loop/lid; other site 1229756002176 ABC transporter signature motif; other site 1229756002177 Walker B; other site 1229756002178 D-loop; other site 1229756002179 H-loop/switch region; other site 1229756002180 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1229756002181 PhoU domain; Region: PhoU; pfam01895 1229756002182 PhoU domain; Region: PhoU; pfam01895 1229756002183 Membrane protein of unknown function; Region: DUF360; pfam04020 1229756002184 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1229756002185 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1229756002186 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1229756002187 Hpr binding site; other site 1229756002188 active site 1229756002189 homohexamer subunit interaction site [polypeptide binding]; other site 1229756002190 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1229756002191 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1229756002192 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1229756002193 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1229756002194 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1229756002195 active site 1229756002196 tetramer interface; other site 1229756002197 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1229756002198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1229756002199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756002200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756002201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756002202 putative substrate translocation pore; other site 1229756002203 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1229756002204 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1229756002205 active site 1229756002206 homodimer interface [polypeptide binding]; other site 1229756002207 catalytic site [active] 1229756002208 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1229756002209 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1229756002210 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1229756002211 active site 1229756002212 substrate binding site [chemical binding]; other site 1229756002213 metal binding site [ion binding]; metal-binding site 1229756002214 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1229756002215 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1229756002216 active site 1229756002217 DNA polymerase IV; Validated; Region: PRK02406 1229756002218 DNA binding site [nucleotide binding] 1229756002219 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1229756002220 DHH family; Region: DHH; pfam01368 1229756002221 DHHA1 domain; Region: DHHA1; pfam02272 1229756002222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1229756002223 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1229756002224 ATP binding site [chemical binding]; other site 1229756002225 Mg++ binding site [ion binding]; other site 1229756002226 motif III; other site 1229756002227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756002228 nucleotide binding region [chemical binding]; other site 1229756002229 ATP-binding site [chemical binding]; other site 1229756002230 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1229756002231 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1229756002232 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1229756002233 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1229756002234 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1229756002235 acyl-activating enzyme (AAE) consensus motif; other site 1229756002236 AMP binding site [chemical binding]; other site 1229756002237 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1229756002238 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1229756002239 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1229756002240 DltD N-terminal region; Region: DltD_N; pfam04915 1229756002241 DltD central region; Region: DltD_M; pfam04918 1229756002242 DltD C-terminal region; Region: DltD_C; pfam04914 1229756002243 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1229756002244 glutamate racemase; Provisional; Region: PRK00865 1229756002245 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1229756002246 active site 1229756002247 dimerization interface [polypeptide binding]; other site 1229756002248 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1229756002249 active site 1229756002250 metal binding site [ion binding]; metal-binding site 1229756002251 homotetramer interface [polypeptide binding]; other site 1229756002252 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1229756002253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756002254 Walker A motif; other site 1229756002255 ATP binding site [chemical binding]; other site 1229756002256 Walker B motif; other site 1229756002257 arginine finger; other site 1229756002258 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1229756002259 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1229756002260 putative active site [active] 1229756002261 putative metal binding site [ion binding]; other site 1229756002262 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1229756002263 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1229756002264 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1229756002265 RuvA N terminal domain; Region: RuvA_N; pfam01330 1229756002266 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1229756002267 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1229756002268 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1229756002269 Substrate-binding site [chemical binding]; other site 1229756002270 Substrate specificity [chemical binding]; other site 1229756002271 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1229756002272 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1229756002273 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1229756002274 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1229756002275 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1229756002276 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1229756002277 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1229756002278 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1229756002279 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1229756002280 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1229756002281 putative substrate binding site [chemical binding]; other site 1229756002282 putative ATP binding site [chemical binding]; other site 1229756002283 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1229756002284 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1229756002285 active site 1229756002286 phosphorylation site [posttranslational modification] 1229756002287 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1229756002288 active site 1229756002289 P-loop; other site 1229756002290 phosphorylation site [posttranslational modification] 1229756002291 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1229756002292 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1229756002293 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1229756002294 DNA binding site [nucleotide binding] 1229756002295 active site 1229756002296 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1229756002297 RimM N-terminal domain; Region: RimM; pfam01782 1229756002298 PRC-barrel domain; Region: PRC; pfam05239 1229756002299 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1229756002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756002301 non-specific DNA binding site [nucleotide binding]; other site 1229756002302 salt bridge; other site 1229756002303 sequence-specific DNA binding site [nucleotide binding]; other site 1229756002304 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1229756002305 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002306 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1229756002307 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1229756002308 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1229756002309 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002310 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002311 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002312 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002313 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756002314 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1229756002315 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1229756002316 Chain length determinant protein; Region: Wzz; cl15801 1229756002317 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1229756002318 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1229756002319 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1229756002320 Nucleotide binding site [chemical binding]; other site 1229756002321 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1229756002322 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1229756002323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1229756002324 LicD family; Region: LicD; pfam04991 1229756002325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756002326 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1229756002327 active site 1229756002328 nucleotide binding site [chemical binding]; other site 1229756002329 HIGH motif; other site 1229756002330 KMSKS motif; other site 1229756002331 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1229756002332 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1229756002333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1229756002334 active site 1229756002335 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1229756002336 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1229756002337 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1229756002338 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1229756002339 active site 1229756002340 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1229756002341 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1229756002342 substrate binding site; other site 1229756002343 tetramer interface; other site 1229756002344 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1229756002345 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1229756002346 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1229756002347 NAD binding site [chemical binding]; other site 1229756002348 substrate binding site [chemical binding]; other site 1229756002349 homodimer interface [polypeptide binding]; other site 1229756002350 active site 1229756002351 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1229756002352 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1229756002353 NADP binding site [chemical binding]; other site 1229756002354 active site 1229756002355 putative substrate binding site [chemical binding]; other site 1229756002356 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1229756002357 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1229756002358 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1229756002359 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1229756002360 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1229756002361 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1229756002362 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1229756002363 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1229756002364 ribonuclease Z; Region: RNase_Z; TIGR02651 1229756002365 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1229756002366 DHH family; Region: DHH; pfam01368 1229756002367 DHHA1 domain; Region: DHHA1; pfam02272 1229756002368 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1229756002369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756002370 active site 1229756002371 Thioredoxin; Region: Thioredoxin_5; pfam13743 1229756002372 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1229756002373 synthetase active site [active] 1229756002374 NTP binding site [chemical binding]; other site 1229756002375 metal binding site [ion binding]; metal-binding site 1229756002376 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1229756002377 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1229756002378 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1229756002379 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1229756002380 active site 1229756002381 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1229756002382 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1229756002383 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1229756002384 Divalent cation transporter; Region: MgtE; pfam01769 1229756002385 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1229756002386 argininosuccinate synthase; Provisional; Region: PRK13820 1229756002387 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1229756002388 ANP binding site [chemical binding]; other site 1229756002389 Substrate Binding Site II [chemical binding]; other site 1229756002390 Substrate Binding Site I [chemical binding]; other site 1229756002391 argininosuccinate lyase; Provisional; Region: PRK00855 1229756002392 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1229756002393 active sites [active] 1229756002394 tetramer interface [polypeptide binding]; other site 1229756002395 ornithine carbamoyltransferase; Validated; Region: PRK02102 1229756002396 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1229756002397 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1229756002398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756002399 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1229756002400 putative substrate translocation pore; other site 1229756002401 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1229756002402 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1229756002403 metal binding site [ion binding]; metal-binding site 1229756002404 dimer interface [polypeptide binding]; other site 1229756002405 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1229756002406 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1229756002407 CutC family; Region: CutC; cl01218 1229756002408 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1229756002409 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1229756002410 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1229756002411 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1229756002412 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1229756002413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756002414 non-specific DNA binding site [nucleotide binding]; other site 1229756002415 salt bridge; other site 1229756002416 sequence-specific DNA binding site [nucleotide binding]; other site 1229756002417 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1229756002418 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1229756002419 active site 1229756002420 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1229756002421 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1229756002422 active site 1229756002423 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1229756002424 substrate binding site [chemical binding]; other site 1229756002425 catalytic residues [active] 1229756002426 dimer interface [polypeptide binding]; other site 1229756002427 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1229756002428 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1229756002429 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1229756002430 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1229756002431 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1229756002432 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1229756002433 metal binding site [ion binding]; metal-binding site 1229756002434 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1229756002435 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1229756002436 dimer interface [polypeptide binding]; other site 1229756002437 active site 1229756002438 catalytic residue [active] 1229756002439 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1229756002440 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1229756002441 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1229756002442 RecX family; Region: RecX; cl00936 1229756002443 hypothetical protein; Provisional; Region: PRK13662 1229756002444 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1229756002445 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1229756002446 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1229756002447 Part of AAA domain; Region: AAA_19; pfam13245 1229756002448 Family description; Region: UvrD_C_2; pfam13538 1229756002449 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1229756002450 Rhomboid family; Region: Rhomboid; pfam01694 1229756002451 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1229756002452 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1229756002453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1229756002454 nucleotide binding site [chemical binding]; other site 1229756002455 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1229756002456 active site 1229756002457 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1229756002458 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1229756002459 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 1229756002460 Surface antigen [General function prediction only]; Region: COG3942 1229756002461 CHAP domain; Region: CHAP; pfam05257 1229756002462 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1229756002463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1229756002464 UDP-galactopyranose mutase; Region: GLF; pfam03275 1229756002465 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1229756002466 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1229756002467 Ligand binding site; other site 1229756002468 Putative Catalytic site; other site 1229756002469 DXD motif; other site 1229756002470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756002471 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1229756002472 active site 1229756002473 nucleotide binding site [chemical binding]; other site 1229756002474 HIGH motif; other site 1229756002475 KMSKS motif; other site 1229756002476 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1229756002477 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1229756002478 Probable Catalytic site; other site 1229756002479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1229756002480 DNA-binding site [nucleotide binding]; DNA binding site 1229756002481 RNA-binding motif; other site 1229756002482 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1229756002483 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1229756002484 dimer interface [polypeptide binding]; other site 1229756002485 ADP-ribose binding site [chemical binding]; other site 1229756002486 active site 1229756002487 nudix motif; other site 1229756002488 metal binding site [ion binding]; metal-binding site 1229756002489 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1229756002490 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1229756002491 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1229756002492 putative tRNA-binding site [nucleotide binding]; other site 1229756002493 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1229756002494 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1229756002495 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756002496 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1229756002497 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1229756002498 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1229756002499 DNA polymerase I; Provisional; Region: PRK05755 1229756002500 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1229756002501 active site 1229756002502 metal binding site 1 [ion binding]; metal-binding site 1229756002503 putative 5' ssDNA interaction site; other site 1229756002504 metal binding site 3; metal-binding site 1229756002505 metal binding site 2 [ion binding]; metal-binding site 1229756002506 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1229756002507 putative DNA binding site [nucleotide binding]; other site 1229756002508 putative metal binding site [ion binding]; other site 1229756002509 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1229756002510 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1229756002511 active site 1229756002512 DNA binding site [nucleotide binding] 1229756002513 catalytic site [active] 1229756002514 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1229756002515 DNA binding residues [nucleotide binding] 1229756002516 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1229756002517 putative dimer interface [polypeptide binding]; other site 1229756002518 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1229756002519 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1229756002520 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1229756002521 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1229756002522 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756002523 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1229756002524 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1229756002525 active site 1 [active] 1229756002526 dimer interface [polypeptide binding]; other site 1229756002527 hexamer interface [polypeptide binding]; other site 1229756002528 active site 2 [active] 1229756002529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756002530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756002531 DNA binding site [nucleotide binding] 1229756002532 domain linker motif; other site 1229756002533 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756002534 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1229756002535 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1229756002536 active site turn [active] 1229756002537 phosphorylation site [posttranslational modification] 1229756002538 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1229756002539 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1229756002540 HPr interaction site; other site 1229756002541 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1229756002542 active site 1229756002543 phosphorylation site [posttranslational modification] 1229756002544 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1229756002545 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1229756002546 substrate binding [chemical binding]; other site 1229756002547 active site 1229756002548 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1229756002549 RNA/DNA hybrid binding site [nucleotide binding]; other site 1229756002550 active site 1229756002551 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1229756002552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756002553 RNA binding surface [nucleotide binding]; other site 1229756002554 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1229756002555 active site 1229756002556 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1229756002557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756002558 active site 1229756002559 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1229756002560 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1229756002561 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1229756002562 catalytic site [active] 1229756002563 subunit interface [polypeptide binding]; other site 1229756002564 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1229756002565 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1229756002566 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1229756002567 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1229756002568 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1229756002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756002570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756002571 putative substrate translocation pore; other site 1229756002572 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1229756002573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756002574 Zn2+ binding site [ion binding]; other site 1229756002575 Mg2+ binding site [ion binding]; other site 1229756002576 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1229756002577 synthetase active site [active] 1229756002578 NTP binding site [chemical binding]; other site 1229756002579 metal binding site [ion binding]; metal-binding site 1229756002580 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1229756002581 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1229756002582 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1229756002583 putative active site [active] 1229756002584 dimerization interface [polypeptide binding]; other site 1229756002585 putative tRNAtyr binding site [nucleotide binding]; other site 1229756002586 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1229756002587 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1229756002588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756002589 ATP binding site [chemical binding]; other site 1229756002590 Mg2+ binding site [ion binding]; other site 1229756002591 G-X-G motif; other site 1229756002592 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1229756002593 anchoring element; other site 1229756002594 dimer interface [polypeptide binding]; other site 1229756002595 ATP binding site [chemical binding]; other site 1229756002596 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1229756002597 active site 1229756002598 putative metal-binding site [ion binding]; other site 1229756002599 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1229756002600 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1229756002601 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1229756002602 CAP-like domain; other site 1229756002603 active site 1229756002604 primary dimer interface [polypeptide binding]; other site 1229756002605 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1229756002606 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1229756002607 DHH family; Region: DHH; pfam01368 1229756002608 DHHA2 domain; Region: DHHA2; pfam02833 1229756002609 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1229756002610 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1229756002611 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1229756002612 Sm and related proteins; Region: Sm_like; cl00259 1229756002613 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1229756002614 putative oligomer interface [polypeptide binding]; other site 1229756002615 putative RNA binding site [nucleotide binding]; other site 1229756002616 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1229756002617 NusA N-terminal domain; Region: NusA_N; pfam08529 1229756002618 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1229756002619 RNA binding site [nucleotide binding]; other site 1229756002620 homodimer interface [polypeptide binding]; other site 1229756002621 NusA-like KH domain; Region: KH_5; pfam13184 1229756002622 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1229756002623 G-X-X-G motif; other site 1229756002624 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1229756002625 putative RNA binding cleft [nucleotide binding]; other site 1229756002626 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1229756002627 translation initiation factor IF-2; Region: IF-2; TIGR00487 1229756002628 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1229756002629 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1229756002630 G1 box; other site 1229756002631 putative GEF interaction site [polypeptide binding]; other site 1229756002632 GTP/Mg2+ binding site [chemical binding]; other site 1229756002633 Switch I region; other site 1229756002634 G2 box; other site 1229756002635 G3 box; other site 1229756002636 Switch II region; other site 1229756002637 G4 box; other site 1229756002638 G5 box; other site 1229756002639 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1229756002640 Translation-initiation factor 2; Region: IF-2; pfam11987 1229756002641 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1229756002642 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1229756002643 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1229756002644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756002645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756002646 homodimer interface [polypeptide binding]; other site 1229756002647 catalytic residue [active] 1229756002648 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1229756002649 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1229756002650 HPr interaction site; other site 1229756002651 active site 1229756002652 phosphorylation site [posttranslational modification] 1229756002653 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1229756002654 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1229756002655 RNA binding site [nucleotide binding]; other site 1229756002656 active site 1229756002657 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1229756002658 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1229756002659 active site 1229756002660 Riboflavin kinase; Region: Flavokinase; smart00904 1229756002661 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1229756002662 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1229756002663 heat shock protein GrpE; Provisional; Region: PRK14140 1229756002664 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1229756002665 dimer interface [polypeptide binding]; other site 1229756002666 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1229756002667 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1229756002668 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1229756002669 nucleotide binding site [chemical binding]; other site 1229756002670 NEF interaction site [polypeptide binding]; other site 1229756002671 SBD interface [polypeptide binding]; other site 1229756002672 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1229756002673 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1229756002674 HSP70 interaction site [polypeptide binding]; other site 1229756002675 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1229756002676 substrate binding site [polypeptide binding]; other site 1229756002677 dimer interface [polypeptide binding]; other site 1229756002678 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1229756002679 active site 1229756002680 catalytic residues [active] 1229756002681 metal binding site [ion binding]; metal-binding site 1229756002682 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1229756002683 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1229756002684 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1229756002685 active site 1229756002686 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1229756002687 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1229756002688 G1 box; other site 1229756002689 putative GEF interaction site [polypeptide binding]; other site 1229756002690 GTP/Mg2+ binding site [chemical binding]; other site 1229756002691 Switch I region; other site 1229756002692 G2 box; other site 1229756002693 G3 box; other site 1229756002694 Switch II region; other site 1229756002695 G4 box; other site 1229756002696 G5 box; other site 1229756002697 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1229756002698 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1229756002699 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1229756002700 Helix-turn-helix domain; Region: HTH_38; pfam13936 1229756002701 Integrase core domain; Region: rve; pfam00665 1229756002702 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1229756002703 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1229756002704 active site 1229756002705 catalytic triad [active] 1229756002706 oxyanion hole [active] 1229756002707 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1229756002708 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1229756002709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1229756002710 active site 1229756002711 metal binding site [ion binding]; metal-binding site 1229756002712 DNA binding site [nucleotide binding] 1229756002713 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1229756002714 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1229756002715 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1229756002716 generic binding surface II; other site 1229756002717 generic binding surface I; other site 1229756002718 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1229756002719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756002720 Zn2+ binding site [ion binding]; other site 1229756002721 Mg2+ binding site [ion binding]; other site 1229756002722 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1229756002723 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1229756002724 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1229756002725 HIT family signature motif; other site 1229756002726 catalytic residue [active] 1229756002727 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1229756002728 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1229756002729 Walker A/P-loop; other site 1229756002730 ATP binding site [chemical binding]; other site 1229756002731 Q-loop/lid; other site 1229756002732 ABC transporter signature motif; other site 1229756002733 Walker B; other site 1229756002734 D-loop; other site 1229756002735 H-loop/switch region; other site 1229756002736 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1229756002737 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1229756002738 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1229756002739 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1229756002740 Int/Topo IB signature motif; other site 1229756002741 Predicted ATPase [General function prediction only]; Region: COG5293 1229756002742 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1229756002743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756002744 non-specific DNA binding site [nucleotide binding]; other site 1229756002745 salt bridge; other site 1229756002746 sequence-specific DNA binding site [nucleotide binding]; other site 1229756002747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1229756002748 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1229756002749 Protein of unknown function (DUF722); Region: DUF722; pfam05263 1229756002750 Homeodomain-like domain; Region: HTH_23; pfam13384 1229756002751 Terminase small subunit; Region: Terminase_2; cl01513 1229756002752 Phage terminase large subunit; Region: Terminase_3; cl12054 1229756002753 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1229756002754 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1229756002755 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1229756002756 cofactor binding site; other site 1229756002757 DNA binding site [nucleotide binding] 1229756002758 substrate interaction site [chemical binding]; other site 1229756002759 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1229756002760 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1229756002761 MepB protein; Region: MepB; pfam08877 1229756002762 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1229756002763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756002764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756002765 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1229756002766 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1229756002767 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1229756002768 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1229756002769 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1229756002770 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1229756002771 active site 1229756002772 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1229756002773 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1229756002774 active site 1229756002775 metal binding site [ion binding]; metal-binding site 1229756002776 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1229756002777 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1229756002778 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1229756002779 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1229756002780 homodimer interface [polypeptide binding]; other site 1229756002781 substrate-cofactor binding pocket; other site 1229756002782 catalytic residue [active] 1229756002783 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1229756002784 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1229756002785 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1229756002786 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1229756002787 NAD binding site [chemical binding]; other site 1229756002788 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756002789 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1229756002790 putative active site [active] 1229756002791 catalytic site [active] 1229756002792 putative metal binding site [ion binding]; other site 1229756002793 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1229756002794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1229756002795 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1229756002796 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1229756002797 FMN binding site [chemical binding]; other site 1229756002798 active site 1229756002799 catalytic residues [active] 1229756002800 substrate binding site [chemical binding]; other site 1229756002801 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1229756002802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756002803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1229756002804 HicB family; Region: HicB; pfam05534 1229756002805 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1229756002806 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1229756002807 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1229756002808 Flavoprotein; Region: Flavoprotein; pfam02441 1229756002809 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1229756002810 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1229756002811 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1229756002812 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1229756002813 active site 1229756002814 HIGH motif; other site 1229756002815 KMSK motif region; other site 1229756002816 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1229756002817 tRNA binding surface [nucleotide binding]; other site 1229756002818 anticodon binding site; other site 1229756002819 Arginine repressor [Transcription]; Region: ArgR; COG1438 1229756002820 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1229756002821 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1229756002822 Transglycosylase; Region: Transgly; pfam00912 1229756002823 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1229756002824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1229756002825 Protein of unknown function (DUF964); Region: DUF964; cl01483 1229756002826 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1229756002827 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1229756002828 Catalytic site [active] 1229756002829 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1229756002830 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1229756002831 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1229756002832 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1229756002833 dihydroorotase; Validated; Region: pyrC; PRK09357 1229756002834 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1229756002835 active site 1229756002836 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1229756002837 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1229756002838 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1229756002839 catalytic site [active] 1229756002840 subunit interface [polypeptide binding]; other site 1229756002841 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1229756002842 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1229756002843 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1229756002844 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1229756002845 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1229756002846 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1229756002847 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1229756002848 IMP binding site; other site 1229756002849 dimer interface [polypeptide binding]; other site 1229756002850 interdomain contacts; other site 1229756002851 partial ornithine binding site; other site 1229756002852 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1229756002853 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1229756002854 heterodimer interface [polypeptide binding]; other site 1229756002855 active site 1229756002856 FMN binding site [chemical binding]; other site 1229756002857 homodimer interface [polypeptide binding]; other site 1229756002858 substrate binding site [chemical binding]; other site 1229756002859 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1229756002860 active site 1229756002861 dimer interface [polypeptide binding]; other site 1229756002862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756002863 active site 1229756002864 LexA repressor; Validated; Region: PRK00215 1229756002865 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1229756002866 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1229756002867 Catalytic site [active] 1229756002868 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1229756002869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1229756002870 putative acyl-acceptor binding pocket; other site 1229756002871 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1229756002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756002873 S-adenosylmethionine binding site [chemical binding]; other site 1229756002874 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1229756002875 GIY-YIG motif/motif A; other site 1229756002876 putative active site [active] 1229756002877 putative metal binding site [ion binding]; other site 1229756002878 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1229756002879 rRNA interaction site [nucleotide binding]; other site 1229756002880 S8 interaction site; other site 1229756002881 putative laminin-1 binding site; other site 1229756002882 elongation factor Ts; Provisional; Region: tsf; PRK09377 1229756002883 UBA/TS-N domain; Region: UBA; pfam00627 1229756002884 Elongation factor TS; Region: EF_TS; pfam00889 1229756002885 Elongation factor TS; Region: EF_TS; pfam00889 1229756002886 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1229756002887 putative nucleotide binding site [chemical binding]; other site 1229756002888 uridine monophosphate binding site [chemical binding]; other site 1229756002889 homohexameric interface [polypeptide binding]; other site 1229756002890 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1229756002891 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1229756002892 hinge region; other site 1229756002893 Protein of unknown function (DUF805); Region: DUF805; cl01224 1229756002894 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1229756002895 motif 1; other site 1229756002896 dimer interface [polypeptide binding]; other site 1229756002897 active site 1229756002898 motif 2; other site 1229756002899 motif 3; other site 1229756002900 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1229756002901 putative oxidoreductase; Provisional; Region: PRK10206 1229756002902 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1229756002903 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1229756002904 GTP-binding protein LepA; Provisional; Region: PRK05433 1229756002905 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1229756002906 G1 box; other site 1229756002907 putative GEF interaction site [polypeptide binding]; other site 1229756002908 GTP/Mg2+ binding site [chemical binding]; other site 1229756002909 Switch I region; other site 1229756002910 G2 box; other site 1229756002911 G3 box; other site 1229756002912 Switch II region; other site 1229756002913 G4 box; other site 1229756002914 G5 box; other site 1229756002915 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1229756002916 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1229756002917 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1229756002918 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1229756002919 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1229756002920 putative NAD(P) binding site [chemical binding]; other site 1229756002921 dimer interface [polypeptide binding]; other site 1229756002922 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1229756002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756002924 S-adenosylmethionine binding site [chemical binding]; other site 1229756002925 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1229756002926 RNA methyltransferase, RsmE family; Region: TIGR00046 1229756002927 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1229756002928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756002929 Walker A/P-loop; other site 1229756002930 ATP binding site [chemical binding]; other site 1229756002931 Q-loop/lid; other site 1229756002932 ABC transporter signature motif; other site 1229756002933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756002934 Walker B; other site 1229756002935 D-loop; other site 1229756002936 ABC transporter; Region: ABC_tran_2; pfam12848 1229756002937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756002938 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1229756002939 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1229756002940 dimer interface [polypeptide binding]; other site 1229756002941 active site 1229756002942 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1229756002943 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1229756002944 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1229756002945 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1229756002946 active site 1229756002947 DNA binding site [nucleotide binding] 1229756002948 Int/Topo IB signature motif; other site 1229756002949 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1229756002950 active site 1229756002951 catalytic residues [active] 1229756002952 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1229756002953 phosphate binding site [ion binding]; other site 1229756002954 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1229756002955 active site 1229756002956 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1229756002957 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1229756002958 active site 1229756002959 dimerization interface [polypeptide binding]; other site 1229756002960 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1229756002961 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1229756002962 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1229756002963 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1229756002964 RNA binding site [nucleotide binding]; other site 1229756002965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756002966 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1229756002967 Coenzyme A binding pocket [chemical binding]; other site 1229756002968 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1229756002969 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756002970 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1229756002971 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1229756002972 dimer interface [polypeptide binding]; other site 1229756002973 substrate binding site [chemical binding]; other site 1229756002974 ATP binding site [chemical binding]; other site 1229756002975 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1229756002976 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1229756002977 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1229756002978 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1229756002979 dimer interface [polypeptide binding]; other site 1229756002980 tetramer interface [polypeptide binding]; other site 1229756002981 PYR/PP interface [polypeptide binding]; other site 1229756002982 TPP binding site [chemical binding]; other site 1229756002983 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1229756002984 TPP-binding site; other site 1229756002985 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1229756002986 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1229756002987 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1229756002988 metal binding site [ion binding]; metal-binding site 1229756002989 substrate binding pocket [chemical binding]; other site 1229756002990 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1229756002991 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1229756002992 dimer interface [polypeptide binding]; other site 1229756002993 active site 1229756002994 metal binding site [ion binding]; metal-binding site 1229756002995 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1229756002996 Family of unknown function (DUF633); Region: DUF633; pfam04816 1229756002997 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1229756002998 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1229756002999 peptidase T; Region: peptidase-T; TIGR01882 1229756003000 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1229756003001 metal binding site [ion binding]; metal-binding site 1229756003002 dimer interface [polypeptide binding]; other site 1229756003003 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1229756003004 active site 1229756003005 catalytic triad [active] 1229756003006 oxyanion hole [active] 1229756003007 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1229756003008 hypothetical protein; Provisional; Region: PRK13672 1229756003009 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1229756003010 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1229756003011 GTP/Mg2+ binding site [chemical binding]; other site 1229756003012 G4 box; other site 1229756003013 G5 box; other site 1229756003014 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1229756003015 G1 box; other site 1229756003016 G1 box; other site 1229756003017 GTP/Mg2+ binding site [chemical binding]; other site 1229756003018 Switch I region; other site 1229756003019 G2 box; other site 1229756003020 G2 box; other site 1229756003021 G3 box; other site 1229756003022 G3 box; other site 1229756003023 Switch II region; other site 1229756003024 Switch II region; other site 1229756003025 G4 box; other site 1229756003026 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1229756003027 RNA/DNA hybrid binding site [nucleotide binding]; other site 1229756003028 active site 1229756003029 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1229756003030 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1229756003031 ligand binding site [chemical binding]; other site 1229756003032 flexible hinge region; other site 1229756003033 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1229756003034 non-specific DNA interactions [nucleotide binding]; other site 1229756003035 DNA binding site [nucleotide binding] 1229756003036 sequence specific DNA binding site [nucleotide binding]; other site 1229756003037 putative cAMP binding site [chemical binding]; other site 1229756003038 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1229756003039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1229756003040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756003041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1229756003042 Domain of unknown function DUF77; Region: DUF77; pfam01910 1229756003043 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1229756003044 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1229756003045 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1229756003046 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1229756003047 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1229756003048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756003049 S-adenosylmethionine binding site [chemical binding]; other site 1229756003050 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1229756003051 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1229756003052 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1229756003053 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1229756003054 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1229756003055 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1229756003056 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1229756003057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756003058 motif II; other site 1229756003059 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1229756003060 Predicted membrane protein [Function unknown]; Region: COG2261 1229756003061 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1229756003062 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1229756003063 active site 1229756003064 catalytic tetrad [active] 1229756003065 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1229756003066 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1229756003067 putative active site [active] 1229756003068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1229756003069 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1229756003070 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1229756003071 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1229756003072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1229756003073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1229756003074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1229756003075 dimerization interface [polypeptide binding]; other site 1229756003076 malate dehydrogenase; Provisional; Region: PRK13529 1229756003077 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1229756003078 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1229756003079 NAD(P) binding site [chemical binding]; other site 1229756003080 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1229756003081 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1229756003082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003083 putative substrate translocation pore; other site 1229756003084 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756003085 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1229756003086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1229756003087 active site 1229756003088 metal binding site [ion binding]; metal-binding site 1229756003089 hypothetical protein; Provisional; Region: PRK13688 1229756003090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756003091 Coenzyme A binding pocket [chemical binding]; other site 1229756003092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756003093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1229756003094 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756003095 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756003096 Walker A/P-loop; other site 1229756003097 ATP binding site [chemical binding]; other site 1229756003098 Q-loop/lid; other site 1229756003099 ABC transporter signature motif; other site 1229756003100 Walker B; other site 1229756003101 D-loop; other site 1229756003102 H-loop/switch region; other site 1229756003103 Predicted membrane protein [Function unknown]; Region: COG2261 1229756003104 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1229756003105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1229756003106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003107 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003108 salt bridge; other site 1229756003109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003110 putative substrate translocation pore; other site 1229756003111 H+ Antiporter protein; Region: 2A0121; TIGR00900 1229756003112 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1229756003113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1229756003114 NAD binding site [chemical binding]; other site 1229756003115 catalytic residues [active] 1229756003116 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1229756003117 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1229756003118 DNA binding residues [nucleotide binding] 1229756003119 putative dimer interface [polypeptide binding]; other site 1229756003120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756003122 putative substrate translocation pore; other site 1229756003123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756003124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756003125 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1229756003126 conserved cys residue [active] 1229756003127 LssY C-terminus; Region: LssY_C; pfam14067 1229756003128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756003129 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1229756003130 NAD(P) binding site [chemical binding]; other site 1229756003131 SAP domain; Region: SAP; pfam02037 1229756003132 SnoaL-like domain; Region: SnoaL_2; pfam12680 1229756003133 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1229756003134 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1229756003135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003136 non-specific DNA binding site [nucleotide binding]; other site 1229756003137 salt bridge; other site 1229756003138 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003139 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1229756003140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003141 non-specific DNA binding site [nucleotide binding]; other site 1229756003142 salt bridge; other site 1229756003143 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003144 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1229756003145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003146 salt bridge; other site 1229756003147 non-specific DNA binding site [nucleotide binding]; other site 1229756003148 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003149 Replication initiation factor; Region: Rep_trans; pfam02486 1229756003150 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756003151 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1229756003152 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1229756003153 dimer interface [polypeptide binding]; other site 1229756003154 FMN binding site [chemical binding]; other site 1229756003155 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1229756003156 Helix-turn-helix domain; Region: HTH_38; pfam13936 1229756003157 Integrase core domain; Region: rve; pfam00665 1229756003158 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1229756003159 Protein of unknown function DUF262; Region: DUF262; pfam03235 1229756003160 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1229756003161 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1229756003162 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1229756003163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756003164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756003165 potential frameshift: common BLAST hit: gi|300173306|ref|YP_003772472.1| LD-carboxypeptidase 1229756003166 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1229756003167 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1229756003168 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1229756003169 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1229756003170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003171 Walker A/P-loop; other site 1229756003172 ATP binding site [chemical binding]; other site 1229756003173 Q-loop/lid; other site 1229756003174 ABC transporter signature motif; other site 1229756003175 Walker B; other site 1229756003176 D-loop; other site 1229756003177 H-loop/switch region; other site 1229756003178 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1229756003179 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1229756003180 GntP family permease; Region: GntP_permease; pfam02447 1229756003181 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1229756003182 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1229756003183 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1229756003184 NADP binding site [chemical binding]; other site 1229756003185 homodimer interface [polypeptide binding]; other site 1229756003186 active site 1229756003187 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756003188 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756003189 DNA binding site [nucleotide binding] 1229756003190 domain linker motif; other site 1229756003191 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756003192 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1229756003193 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003194 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1229756003195 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1229756003196 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003197 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003198 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003199 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003200 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756003201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756003202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003203 non-specific DNA binding site [nucleotide binding]; other site 1229756003204 salt bridge; other site 1229756003205 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003206 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1229756003207 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1229756003208 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1229756003209 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1229756003210 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1229756003211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756003212 motif II; other site 1229756003213 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1229756003214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1229756003215 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1229756003216 active site 1229756003217 catalytic tetrad [active] 1229756003218 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1229756003219 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1229756003220 catalytic residues [active] 1229756003221 dimer interface [polypeptide binding]; other site 1229756003222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1229756003223 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1229756003224 putative NAD(P) binding site [chemical binding]; other site 1229756003225 catalytic Zn binding site [ion binding]; other site 1229756003226 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1229756003227 classical (c) SDRs; Region: SDR_c; cd05233 1229756003228 NAD(P) binding site [chemical binding]; other site 1229756003229 active site 1229756003230 QueT transporter; Region: QueT; pfam06177 1229756003231 HeH/LEM domain; Region: HeH; pfam12949 1229756003232 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1229756003233 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1229756003234 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1229756003235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1229756003236 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1229756003237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1229756003238 DNA binding residues [nucleotide binding] 1229756003239 DNA primase; Validated; Region: dnaG; PRK05667 1229756003240 CHC2 zinc finger; Region: zf-CHC2; cl17510 1229756003241 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1229756003242 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1229756003243 active site 1229756003244 metal binding site [ion binding]; metal-binding site 1229756003245 interdomain interaction site; other site 1229756003246 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 1229756003247 Y-family of DNA polymerases; Region: PolY; cl12025 1229756003248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756003249 Coenzyme A binding pocket [chemical binding]; other site 1229756003250 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 1229756003251 potential frameshift: common BLAST hit: gi|385830413|ref|YP_005868226.1| family 2 glycosyltransferase 1229756003252 short chain dehydrogenase; Provisional; Region: PRK08219 1229756003253 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1229756003254 dimer interface [polypeptide binding]; other site 1229756003255 FMN binding site [chemical binding]; other site 1229756003256 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756003257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756003259 putative substrate translocation pore; other site 1229756003260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756003261 dimerization interface [polypeptide binding]; other site 1229756003262 putative DNA binding site [nucleotide binding]; other site 1229756003263 putative Zn2+ binding site [ion binding]; other site 1229756003264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756003265 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1229756003266 NAD(P) binding site [chemical binding]; other site 1229756003267 active site 1229756003268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1229756003269 TAP-like protein; Region: Abhydrolase_4; pfam08386 1229756003270 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1229756003271 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756003272 putative NAD(P) binding site [chemical binding]; other site 1229756003273 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1229756003274 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1229756003275 putative NAD(P) binding site [chemical binding]; other site 1229756003276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756003277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756003278 Predicted transcriptional regulator [Transcription]; Region: COG4189 1229756003279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756003280 putative DNA binding site [nucleotide binding]; other site 1229756003281 dimerization interface [polypeptide binding]; other site 1229756003282 putative Zn2+ binding site [ion binding]; other site 1229756003283 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1229756003284 active site 1229756003285 galactoside permease; Reviewed; Region: lacY; PRK09528 1229756003286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003287 putative substrate translocation pore; other site 1229756003288 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1229756003289 putative active site [active] 1229756003290 DNA polymerase IV; Reviewed; Region: PRK03103 1229756003291 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1229756003292 active site 1229756003293 DNA binding site [nucleotide binding] 1229756003294 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1229756003295 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1229756003296 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1229756003297 trimer interface [polypeptide binding]; other site 1229756003298 active site 1229756003299 substrate binding site [chemical binding]; other site 1229756003300 CoA binding site [chemical binding]; other site 1229756003301 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1229756003302 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1229756003303 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1229756003304 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1229756003305 DNA binding site [nucleotide binding] 1229756003306 active site 1229756003307 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1229756003308 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1229756003309 tetramer interface [polypeptide binding]; other site 1229756003310 active site 1229756003311 Mg2+/Mn2+ binding site [ion binding]; other site 1229756003312 hypothetical protein; Validated; Region: PRK06769 1229756003313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756003314 active site 1229756003315 motif I; other site 1229756003316 motif II; other site 1229756003317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003318 Walker A/P-loop; other site 1229756003319 ATP binding site [chemical binding]; other site 1229756003320 Q-loop/lid; other site 1229756003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003322 ABC transporter signature motif; other site 1229756003323 Walker B; other site 1229756003324 D-loop; other site 1229756003325 H-loop/switch region; other site 1229756003326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003327 AAA domain; Region: AAA_21; pfam13304 1229756003328 Walker A/P-loop; other site 1229756003329 ATP binding site [chemical binding]; other site 1229756003330 Q-loop/lid; other site 1229756003331 ABC transporter signature motif; other site 1229756003332 Walker B; other site 1229756003333 D-loop; other site 1229756003334 H-loop/switch region; other site 1229756003335 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1229756003336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1229756003337 potential frameshift: common BLAST hit: gi|339490624|ref|YP_004705129.1| phenazine biosynthesis protein PhzF family 1229756003338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003339 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1229756003340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003341 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1229756003342 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003345 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756003346 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1229756003347 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756003348 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756003349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756003350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756003351 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1229756003352 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1229756003353 Cl- selectivity filter; other site 1229756003354 Cl- binding residues [ion binding]; other site 1229756003355 pore gating glutamate residue; other site 1229756003356 dimer interface [polypeptide binding]; other site 1229756003357 H+/Cl- coupling transport residue; other site 1229756003358 TrkA-C domain; Region: TrkA_C; pfam02080 1229756003359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756003360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003361 non-specific DNA binding site [nucleotide binding]; other site 1229756003362 salt bridge; other site 1229756003363 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003364 Cupin domain; Region: Cupin_2; pfam07883 1229756003365 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1229756003366 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1229756003367 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1229756003368 PYR/PP interface [polypeptide binding]; other site 1229756003369 dimer interface [polypeptide binding]; other site 1229756003370 tetramer interface [polypeptide binding]; other site 1229756003371 TPP binding site [chemical binding]; other site 1229756003372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1229756003373 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1229756003374 TPP-binding site [chemical binding]; other site 1229756003375 LrgB-like family; Region: LrgB; cl00596 1229756003376 LrgA family; Region: LrgA; cl00608 1229756003377 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1229756003378 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756003379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756003380 non-specific DNA binding site [nucleotide binding]; other site 1229756003381 salt bridge; other site 1229756003382 sequence-specific DNA binding site [nucleotide binding]; other site 1229756003383 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1229756003384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1229756003385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1229756003386 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1229756003387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756003388 dimer interface [polypeptide binding]; other site 1229756003389 conserved gate region; other site 1229756003390 putative PBP binding loops; other site 1229756003391 ABC-ATPase subunit interface; other site 1229756003392 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1229756003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756003394 dimer interface [polypeptide binding]; other site 1229756003395 conserved gate region; other site 1229756003396 putative PBP binding loops; other site 1229756003397 ABC-ATPase subunit interface; other site 1229756003398 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1229756003399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003400 Walker A/P-loop; other site 1229756003401 ATP binding site [chemical binding]; other site 1229756003402 Q-loop/lid; other site 1229756003403 ABC transporter signature motif; other site 1229756003404 Walker B; other site 1229756003405 D-loop; other site 1229756003406 H-loop/switch region; other site 1229756003407 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1229756003408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003409 putative substrate translocation pore; other site 1229756003410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003411 Collagen binding domain; Region: Collagen_bind; pfam05737 1229756003412 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1229756003413 domain interaction interfaces [polypeptide binding]; other site 1229756003414 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1229756003415 domain interaction interfaces [polypeptide binding]; other site 1229756003416 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1229756003417 N-glycosyltransferase; Provisional; Region: PRK11204 1229756003418 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1229756003419 DXD motif; other site 1229756003420 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1229756003421 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1229756003422 legume lectins; Region: lectin_L-type; cl14058 1229756003423 homotetramer interaction site [polypeptide binding]; other site 1229756003424 carbohydrate binding site [chemical binding]; other site 1229756003425 metal binding site [ion binding]; metal-binding site 1229756003426 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1229756003427 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1229756003428 MarR family; Region: MarR_2; pfam12802 1229756003429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1229756003430 hydrophobic ligand binding site; other site 1229756003431 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1229756003432 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1229756003433 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1229756003434 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1229756003435 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 1229756003436 active site 1229756003437 phosphorylation site [posttranslational modification] 1229756003438 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1229756003439 active pocket/dimerization site; other site 1229756003440 active site 1229756003441 phosphorylation site [posttranslational modification] 1229756003442 DNA topoisomerase I; Validated; Region: PRK05582 1229756003443 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1229756003444 active site 1229756003445 interdomain interaction site; other site 1229756003446 putative metal-binding site [ion binding]; other site 1229756003447 nucleotide binding site [chemical binding]; other site 1229756003448 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1229756003449 domain I; other site 1229756003450 DNA binding groove [nucleotide binding] 1229756003451 phosphate binding site [ion binding]; other site 1229756003452 domain II; other site 1229756003453 domain III; other site 1229756003454 nucleotide binding site [chemical binding]; other site 1229756003455 catalytic site [active] 1229756003456 domain IV; other site 1229756003457 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1229756003458 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1229756003459 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1229756003460 DNA protecting protein DprA; Region: dprA; TIGR00732 1229756003461 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1229756003462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756003463 Walker A/P-loop; other site 1229756003464 ATP binding site [chemical binding]; other site 1229756003465 Q-loop/lid; other site 1229756003466 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756003467 ABC transporter signature motif; other site 1229756003468 Walker B; other site 1229756003469 D-loop; other site 1229756003470 ABC transporter; Region: ABC_tran_2; pfam12848 1229756003471 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1229756003472 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1229756003473 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1229756003474 active site 1229756003475 FMN binding site [chemical binding]; other site 1229756003476 substrate binding site [chemical binding]; other site 1229756003477 catalytic residues [active] 1229756003478 homodimer interface [polypeptide binding]; other site 1229756003479 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1229756003480 propionate/acetate kinase; Provisional; Region: PRK12379 1229756003481 Bacterial SH3 domain; Region: SH3_3; pfam08239 1229756003482 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1229756003483 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1229756003484 active site 1229756003485 metal binding site [ion binding]; metal-binding site 1229756003486 Predicted membrane protein [Function unknown]; Region: COG2259 1229756003487 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1229756003488 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1229756003489 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1229756003490 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1229756003491 dimer interface [polypeptide binding]; other site 1229756003492 active site 1229756003493 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1229756003494 folate binding site [chemical binding]; other site 1229756003495 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1229756003496 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1229756003497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756003498 catalytic residue [active] 1229756003499 homoserine dehydrogenase; Provisional; Region: PRK06349 1229756003500 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1229756003501 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1229756003502 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1229756003503 homoserine kinase; Provisional; Region: PRK01212 1229756003504 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1229756003505 aspartate kinase; Reviewed; Region: PRK09034 1229756003506 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1229756003507 putative catalytic residues [active] 1229756003508 putative nucleotide binding site [chemical binding]; other site 1229756003509 putative aspartate binding site [chemical binding]; other site 1229756003510 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1229756003511 allosteric regulatory residue; other site 1229756003512 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1229756003513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756003514 catalytic core [active] 1229756003515 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1229756003516 active site 1229756003517 homotetramer interface [polypeptide binding]; other site 1229756003518 homodimer interface [polypeptide binding]; other site 1229756003519 Recombination protein O N terminal; Region: RecO_N; pfam11967 1229756003520 DNA repair protein RecO; Region: reco; TIGR00613 1229756003521 Recombination protein O C terminal; Region: RecO_C; pfam02565 1229756003522 GTPase Era; Reviewed; Region: era; PRK00089 1229756003523 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1229756003524 G1 box; other site 1229756003525 GTP/Mg2+ binding site [chemical binding]; other site 1229756003526 Switch I region; other site 1229756003527 G2 box; other site 1229756003528 Switch II region; other site 1229756003529 G3 box; other site 1229756003530 G4 box; other site 1229756003531 G5 box; other site 1229756003532 KH domain; Region: KH_2; pfam07650 1229756003533 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1229756003534 metal-binding heat shock protein; Provisional; Region: PRK00016 1229756003535 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1229756003536 PhoH-like protein; Region: PhoH; pfam02562 1229756003537 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1229756003538 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1229756003539 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1229756003540 domain interfaces; other site 1229756003541 active site 1229756003542 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1229756003543 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1229756003544 active site 1229756003545 PHP Thumb interface [polypeptide binding]; other site 1229756003546 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1229756003547 generic binding surface I; other site 1229756003548 generic binding surface II; other site 1229756003549 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1229756003550 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1229756003551 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1229756003552 active site 1229756003553 catalytic residue [active] 1229756003554 dimer interface [polypeptide binding]; other site 1229756003555 Prephenate dehydratase; Region: PDT; pfam00800 1229756003556 shikimate kinase; Reviewed; Region: aroK; PRK00131 1229756003557 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1229756003558 ADP binding site [chemical binding]; other site 1229756003559 magnesium binding site [ion binding]; other site 1229756003560 putative shikimate binding site; other site 1229756003561 Chorismate mutase type II; Region: CM_2; smart00830 1229756003562 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1229756003563 prephenate dehydrogenase; Validated; Region: PRK08507 1229756003564 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1229756003565 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1229756003566 hinge; other site 1229756003567 active site 1229756003568 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1229756003569 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1229756003570 Tetramer interface [polypeptide binding]; other site 1229756003571 active site 1229756003572 FMN-binding site [chemical binding]; other site 1229756003573 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1229756003574 active site 1229756003575 dimer interface [polypeptide binding]; other site 1229756003576 metal binding site [ion binding]; metal-binding site 1229756003577 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1229756003578 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1229756003579 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1229756003580 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1229756003581 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1229756003582 shikimate binding site; other site 1229756003583 NAD(P) binding site [chemical binding]; other site 1229756003584 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1229756003585 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1229756003586 TPP-binding site [chemical binding]; other site 1229756003587 dimer interface [polypeptide binding]; other site 1229756003588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1229756003589 PYR/PP interface [polypeptide binding]; other site 1229756003590 dimer interface [polypeptide binding]; other site 1229756003591 TPP binding site [chemical binding]; other site 1229756003592 CsbD-like; Region: CsbD; pfam05532 1229756003593 EDD domain protein, DegV family; Region: DegV; TIGR00762 1229756003594 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1229756003595 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1229756003596 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1229756003597 folate binding site [chemical binding]; other site 1229756003598 NADP+ binding site [chemical binding]; other site 1229756003599 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1229756003600 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1229756003601 active site 1229756003602 NTP binding site [chemical binding]; other site 1229756003603 metal binding triad [ion binding]; metal-binding site 1229756003604 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1229756003605 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1229756003606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1229756003607 binding surface 1229756003608 TPR motif; other site 1229756003609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1229756003610 TPR motif; other site 1229756003611 binding surface 1229756003612 TPR repeat; Region: TPR_11; pfam13414 1229756003613 TPR repeat; Region: TPR_11; pfam13414 1229756003614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1229756003615 TPR motif; other site 1229756003616 binding surface 1229756003617 CsbD-like; Region: CsbD; pfam05532 1229756003618 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1229756003619 IHF dimer interface [polypeptide binding]; other site 1229756003620 IHF - DNA interface [nucleotide binding]; other site 1229756003621 GTP-binding protein Der; Reviewed; Region: PRK00093 1229756003622 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1229756003623 G1 box; other site 1229756003624 GTP/Mg2+ binding site [chemical binding]; other site 1229756003625 Switch I region; other site 1229756003626 G2 box; other site 1229756003627 Switch II region; other site 1229756003628 G3 box; other site 1229756003629 G4 box; other site 1229756003630 G5 box; other site 1229756003631 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1229756003632 G1 box; other site 1229756003633 GTP/Mg2+ binding site [chemical binding]; other site 1229756003634 Switch I region; other site 1229756003635 G2 box; other site 1229756003636 G3 box; other site 1229756003637 Switch II region; other site 1229756003638 G4 box; other site 1229756003639 G5 box; other site 1229756003640 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1229756003641 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1229756003642 RNA binding site [nucleotide binding]; other site 1229756003643 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1229756003644 RNA binding site [nucleotide binding]; other site 1229756003645 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1229756003646 RNA binding site [nucleotide binding]; other site 1229756003647 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1229756003648 RNA binding site [nucleotide binding]; other site 1229756003649 cytidylate kinase; Provisional; Region: cmk; PRK00023 1229756003650 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1229756003651 CMP-binding site; other site 1229756003652 The sites determining sugar specificity; other site 1229756003653 Predicted membrane protein [Function unknown]; Region: COG3601 1229756003654 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1229756003655 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1229756003656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756003657 RNA binding surface [nucleotide binding]; other site 1229756003658 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1229756003659 active site 1229756003660 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1229756003661 ScpA/B protein; Region: ScpA_ScpB; cl00598 1229756003662 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1229756003663 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1229756003664 active site 1229756003665 Int/Topo IB signature motif; other site 1229756003666 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1229756003667 S1 domain; Region: S1_2; pfam13509 1229756003668 Yqey-like protein; Region: YqeY; pfam09424 1229756003669 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1229756003670 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1229756003671 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1229756003672 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1229756003673 active site 1229756003674 Zn binding site [ion binding]; other site 1229756003675 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1229756003676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003677 putative substrate translocation pore; other site 1229756003678 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1229756003679 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1229756003680 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1229756003681 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1229756003682 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1229756003683 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1229756003684 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756003685 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1229756003686 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1229756003687 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1229756003688 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1229756003689 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1229756003690 dimer interface [polypeptide binding]; other site 1229756003691 anticodon binding site; other site 1229756003692 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1229756003693 motif 1; other site 1229756003694 dimer interface [polypeptide binding]; other site 1229756003695 active site 1229756003696 motif 2; other site 1229756003697 GAD domain; Region: GAD; pfam02938 1229756003698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1229756003699 active site 1229756003700 motif 3; other site 1229756003701 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1229756003702 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1229756003703 dimer interface [polypeptide binding]; other site 1229756003704 motif 1; other site 1229756003705 active site 1229756003706 motif 2; other site 1229756003707 motif 3; other site 1229756003708 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1229756003709 anticodon binding site; other site 1229756003710 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1229756003711 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1229756003712 Ca binding site [ion binding]; other site 1229756003713 active site 1229756003714 catalytic site [active] 1229756003715 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1229756003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003717 putative substrate translocation pore; other site 1229756003718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756003719 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1229756003720 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1229756003721 Ca binding site [ion binding]; other site 1229756003722 active site 1229756003723 catalytic site [active] 1229756003724 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1229756003725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756003726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756003727 DNA binding site [nucleotide binding] 1229756003728 domain linker motif; other site 1229756003729 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1229756003730 dimerization interface [polypeptide binding]; other site 1229756003731 ligand binding site [chemical binding]; other site 1229756003732 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1229756003733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756003734 motif II; other site 1229756003735 maltose phosphorylase; Provisional; Region: PRK13807 1229756003736 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1229756003737 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1229756003738 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1229756003739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756003741 putative substrate translocation pore; other site 1229756003742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756003743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756003744 DNA binding site [nucleotide binding] 1229756003745 domain linker motif; other site 1229756003746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1229756003747 ligand binding site [chemical binding]; other site 1229756003748 dimerization interface [polypeptide binding]; other site 1229756003749 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756003750 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756003751 DNA binding site [nucleotide binding] 1229756003752 domain linker motif; other site 1229756003753 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756003754 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1229756003755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756003756 dimer interface [polypeptide binding]; other site 1229756003757 conserved gate region; other site 1229756003758 putative PBP binding loops; other site 1229756003759 ABC-ATPase subunit interface; other site 1229756003760 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1229756003761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756003762 dimer interface [polypeptide binding]; other site 1229756003763 conserved gate region; other site 1229756003764 putative PBP binding loops; other site 1229756003765 ABC-ATPase subunit interface; other site 1229756003766 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1229756003767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1229756003768 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1229756003769 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1229756003770 Walker A/P-loop; other site 1229756003771 ATP binding site [chemical binding]; other site 1229756003772 Q-loop/lid; other site 1229756003773 ABC transporter signature motif; other site 1229756003774 Walker B; other site 1229756003775 D-loop; other site 1229756003776 H-loop/switch region; other site 1229756003777 TOBE domain; Region: TOBE; pfam03459 1229756003778 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1229756003779 homodimer interface [polypeptide binding]; other site 1229756003780 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1229756003781 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1229756003782 active site 1229756003783 homodimer interface [polypeptide binding]; other site 1229756003784 catalytic site [active] 1229756003785 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1229756003786 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1229756003787 Ca binding site [ion binding]; other site 1229756003788 active site 1229756003789 catalytic site [active] 1229756003790 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1229756003791 dimer interface [polypeptide binding]; other site 1229756003792 FMN binding site [chemical binding]; other site 1229756003793 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1229756003794 Coenzyme A binding pocket [chemical binding]; other site 1229756003795 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1229756003796 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1229756003797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1229756003798 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1229756003799 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1229756003800 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1229756003801 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1229756003802 putative dimer interface [polypeptide binding]; other site 1229756003803 putative anticodon binding site; other site 1229756003804 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1229756003805 homodimer interface [polypeptide binding]; other site 1229756003806 motif 1; other site 1229756003807 motif 2; other site 1229756003808 active site 1229756003809 motif 3; other site 1229756003810 aspartate aminotransferase; Provisional; Region: PRK05764 1229756003811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756003812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756003813 homodimer interface [polypeptide binding]; other site 1229756003814 catalytic residue [active] 1229756003815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1229756003816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1229756003817 active site 1229756003818 catalytic site [active] 1229756003819 substrate binding site [chemical binding]; other site 1229756003820 mevalonate kinase; Region: mevalon_kin; TIGR00549 1229756003821 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1229756003822 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1229756003823 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1229756003824 active site 1229756003825 catalytic site [active] 1229756003826 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1229756003827 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1229756003828 active site 1229756003829 catalytic tetrad [active] 1229756003830 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1229756003831 active site 1229756003832 catalytic triad [active] 1229756003833 oxyanion hole [active] 1229756003834 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1229756003835 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1229756003836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756003837 active site 1229756003838 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1229756003839 AAA domain; Region: AAA_30; pfam13604 1229756003840 Family description; Region: UvrD_C_2; pfam13538 1229756003841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756003842 catalytic core [active] 1229756003843 Putative amino acid metabolism; Region: DUF1831; pfam08866 1229756003844 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756003845 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1229756003846 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1229756003847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756003848 S-adenosylmethionine binding site [chemical binding]; other site 1229756003849 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1229756003850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1229756003851 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1229756003852 substrate binding site [chemical binding]; other site 1229756003853 dimer interface [polypeptide binding]; other site 1229756003854 ATP binding site [chemical binding]; other site 1229756003855 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1229756003856 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1229756003857 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1229756003858 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1229756003859 generic binding surface II; other site 1229756003860 generic binding surface I; other site 1229756003861 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1229756003862 active site 1229756003863 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1229756003864 active site 1229756003865 catalytic site [active] 1229756003866 substrate binding site [chemical binding]; other site 1229756003867 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1229756003868 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1229756003869 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1229756003870 dimer interface [polypeptide binding]; other site 1229756003871 motif 1; other site 1229756003872 active site 1229756003873 motif 2; other site 1229756003874 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1229756003875 putative deacylase active site [active] 1229756003876 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1229756003877 active site 1229756003878 motif 3; other site 1229756003879 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1229756003880 anticodon binding site; other site 1229756003881 RIP metalloprotease RseP; Region: TIGR00054 1229756003882 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1229756003883 active site 1229756003884 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1229756003885 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1229756003886 protein binding site [polypeptide binding]; other site 1229756003887 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1229756003888 putative substrate binding region [chemical binding]; other site 1229756003889 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1229756003890 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1229756003891 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1229756003892 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1229756003893 catalytic residue [active] 1229756003894 putative FPP diphosphate binding site; other site 1229756003895 putative FPP binding hydrophobic cleft; other site 1229756003896 dimer interface [polypeptide binding]; other site 1229756003897 putative IPP diphosphate binding site; other site 1229756003898 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1229756003899 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1229756003900 glutaminase active site [active] 1229756003901 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1229756003902 dimer interface [polypeptide binding]; other site 1229756003903 active site 1229756003904 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1229756003905 dimer interface [polypeptide binding]; other site 1229756003906 active site 1229756003907 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1229756003908 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1229756003909 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1229756003910 active site 1229756003911 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1229756003912 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1229756003913 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1229756003914 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1229756003915 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1229756003916 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1229756003917 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1229756003918 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1229756003919 diphosphomevalonate decarboxylase; Region: PLN02407 1229756003920 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1229756003921 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1229756003922 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1229756003923 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1229756003924 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1229756003925 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1229756003926 homotetramer interface [polypeptide binding]; other site 1229756003927 FMN binding site [chemical binding]; other site 1229756003928 homodimer contacts [polypeptide binding]; other site 1229756003929 putative active site [active] 1229756003930 putative substrate binding site [chemical binding]; other site 1229756003931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756003932 active site 1229756003933 adenylosuccinate lyase; Provisional; Region: PRK07492 1229756003934 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1229756003935 tetramer interface [polypeptide binding]; other site 1229756003936 active site 1229756003937 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1229756003938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756003939 putative substrate translocation pore; other site 1229756003940 Predicted esterase [General function prediction only]; Region: COG0627 1229756003941 S-formylglutathione hydrolase; Region: PLN02442 1229756003942 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1229756003943 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1229756003944 Potassium binding sites [ion binding]; other site 1229756003945 Cesium cation binding sites [ion binding]; other site 1229756003946 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1229756003947 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1229756003948 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1229756003949 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1229756003950 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1229756003951 putative active site [active] 1229756003952 nucleotide binding site [chemical binding]; other site 1229756003953 nudix motif; other site 1229756003954 putative metal binding site [ion binding]; other site 1229756003955 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1229756003956 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1229756003957 purine monophosphate binding site [chemical binding]; other site 1229756003958 dimer interface [polypeptide binding]; other site 1229756003959 putative catalytic residues [active] 1229756003960 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1229756003961 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1229756003962 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1229756003963 active site 1229756003964 substrate binding site [chemical binding]; other site 1229756003965 cosubstrate binding site; other site 1229756003966 catalytic site [active] 1229756003967 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1229756003968 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1229756003969 dimerization interface [polypeptide binding]; other site 1229756003970 putative ATP binding site [chemical binding]; other site 1229756003971 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1229756003972 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1229756003973 active site 1229756003974 tetramer interface [polypeptide binding]; other site 1229756003975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756003976 active site 1229756003977 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1229756003978 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1229756003979 dimerization interface [polypeptide binding]; other site 1229756003980 ATP binding site [chemical binding]; other site 1229756003981 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1229756003982 dimerization interface [polypeptide binding]; other site 1229756003983 ATP binding site [chemical binding]; other site 1229756003984 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1229756003985 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1229756003986 putative active site [active] 1229756003987 catalytic triad [active] 1229756003988 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1229756003989 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1229756003990 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1229756003991 ATP binding site [chemical binding]; other site 1229756003992 active site 1229756003993 substrate binding site [chemical binding]; other site 1229756003994 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1229756003995 ATP-grasp domain; Region: ATP-grasp; pfam02222 1229756003996 AIR carboxylase; Region: AIRC; pfam00731 1229756003997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756003998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756003999 substrate binding pocket [chemical binding]; other site 1229756004000 membrane-bound complex binding site; other site 1229756004001 hinge residues; other site 1229756004002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756004003 dimer interface [polypeptide binding]; other site 1229756004004 conserved gate region; other site 1229756004005 ABC-ATPase subunit interface; other site 1229756004006 cell division protein GpsB; Provisional; Region: PRK14127 1229756004007 DivIVA domain; Region: DivI1A_domain; TIGR03544 1229756004008 hypothetical protein; Provisional; Region: PRK13660 1229756004009 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1229756004010 Transglycosylase; Region: Transgly; pfam00912 1229756004011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1229756004012 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1229756004013 GMP synthase; Reviewed; Region: guaA; PRK00074 1229756004014 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1229756004015 AMP/PPi binding site [chemical binding]; other site 1229756004016 candidate oxyanion hole; other site 1229756004017 catalytic triad [active] 1229756004018 potential glutamine specificity residues [chemical binding]; other site 1229756004019 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1229756004020 ATP Binding subdomain [chemical binding]; other site 1229756004021 Dimerization subdomain; other site 1229756004022 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1229756004023 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1229756004024 phosphate binding site [ion binding]; other site 1229756004025 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1229756004026 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1229756004027 active site 1229756004028 heat shock protein HtpX; Provisional; Region: PRK04897 1229756004029 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1229756004030 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1229756004031 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1229756004032 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1229756004033 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1229756004034 HIGH motif; other site 1229756004035 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1229756004036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756004037 active site 1229756004038 KMSKS motif; other site 1229756004039 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1229756004040 tRNA binding surface [nucleotide binding]; other site 1229756004041 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1229756004042 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1229756004043 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1229756004044 active site 1229756004045 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1229756004046 active site 1229756004047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1229756004048 Ligand Binding Site [chemical binding]; other site 1229756004049 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1229756004050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1229756004051 active site 1229756004052 dimer interface [polypeptide binding]; other site 1229756004053 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1229756004054 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1229756004055 Walker A/P-loop; other site 1229756004056 ATP binding site [chemical binding]; other site 1229756004057 Q-loop/lid; other site 1229756004058 ABC transporter signature motif; other site 1229756004059 Walker B; other site 1229756004060 D-loop; other site 1229756004061 H-loop/switch region; other site 1229756004062 elongation factor Tu; Reviewed; Region: PRK00049 1229756004063 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1229756004064 G1 box; other site 1229756004065 GEF interaction site [polypeptide binding]; other site 1229756004066 GTP/Mg2+ binding site [chemical binding]; other site 1229756004067 Switch I region; other site 1229756004068 G2 box; other site 1229756004069 G3 box; other site 1229756004070 Switch II region; other site 1229756004071 G4 box; other site 1229756004072 G5 box; other site 1229756004073 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1229756004074 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1229756004075 Antibiotic Binding Site [chemical binding]; other site 1229756004076 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1229756004077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1229756004078 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1229756004079 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1229756004080 23S rRNA binding site [nucleotide binding]; other site 1229756004081 L21 binding site [polypeptide binding]; other site 1229756004082 L13 binding site [polypeptide binding]; other site 1229756004083 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1229756004084 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1229756004085 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1229756004086 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1229756004087 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1229756004088 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1229756004089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1229756004090 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1229756004091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1229756004092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1229756004093 active site 1229756004094 dimer interface [polypeptide binding]; other site 1229756004095 motif 1; other site 1229756004096 motif 2; other site 1229756004097 motif 3; other site 1229756004098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1229756004099 anticodon binding site; other site 1229756004100 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1229756004101 amphipathic channel; other site 1229756004102 Asn-Pro-Ala signature motifs; other site 1229756004103 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1229756004104 hypothetical protein; Validated; Region: PRK00110 1229756004105 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1229756004106 tetramer interfaces [polypeptide binding]; other site 1229756004107 binuclear metal-binding site [ion binding]; other site 1229756004108 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1229756004109 putative ligand binding site [chemical binding]; other site 1229756004110 putative NAD binding site [chemical binding]; other site 1229756004111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1229756004112 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1229756004113 L-serine binding site [chemical binding]; other site 1229756004114 ACT domain interface; other site 1229756004115 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1229756004116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1229756004117 catalytic residue [active] 1229756004118 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1229756004119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756004120 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1229756004121 Walker A/P-loop; other site 1229756004122 ATP binding site [chemical binding]; other site 1229756004123 Q-loop/lid; other site 1229756004124 ABC transporter signature motif; other site 1229756004125 Walker B; other site 1229756004126 D-loop; other site 1229756004127 H-loop/switch region; other site 1229756004128 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1229756004129 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1229756004130 ligand binding site [chemical binding]; other site 1229756004131 active site 1229756004132 UGI interface [polypeptide binding]; other site 1229756004133 catalytic site [active] 1229756004134 Tubby C 2; Region: Tub_2; cl02043 1229756004135 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1229756004136 FAD binding site [chemical binding]; other site 1229756004137 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1229756004138 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1229756004139 S-methylmethionine transporter; Provisional; Region: PRK11387 1229756004140 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1229756004141 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1229756004142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756004143 active site 1229756004144 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1229756004145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756004146 active site 1229756004147 HIGH motif; other site 1229756004148 nucleotide binding site [chemical binding]; other site 1229756004149 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1229756004150 active site 1229756004151 KMSKS motif; other site 1229756004152 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1229756004153 tRNA binding surface [nucleotide binding]; other site 1229756004154 anticodon binding site; other site 1229756004155 DivIVA protein; Region: DivIVA; pfam05103 1229756004156 DivIVA domain; Region: DivI1A_domain; TIGR03544 1229756004157 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1229756004158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756004159 RNA binding surface [nucleotide binding]; other site 1229756004160 YGGT family; Region: YGGT; cl00508 1229756004161 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1229756004162 cell division protein FtsZ; Validated; Region: PRK09330 1229756004163 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1229756004164 nucleotide binding site [chemical binding]; other site 1229756004165 SulA interaction site; other site 1229756004166 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1229756004167 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1229756004168 nucleotide binding site [chemical binding]; other site 1229756004169 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1229756004170 Cell division protein FtsA; Region: FtsA; pfam14450 1229756004171 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1229756004172 Cell division protein FtsQ; Region: FtsQ; pfam03799 1229756004173 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1229756004174 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1229756004175 active site 1229756004176 homodimer interface [polypeptide binding]; other site 1229756004177 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1229756004178 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756004179 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1229756004180 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1229756004181 Mg++ binding site [ion binding]; other site 1229756004182 putative catalytic motif [active] 1229756004183 putative substrate binding site [chemical binding]; other site 1229756004184 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1229756004185 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1229756004186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1229756004187 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1229756004188 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1229756004189 Cell division protein FtsL; Region: FtsL; cl11433 1229756004190 MraW methylase family; Region: Methyltransf_5; pfam01795 1229756004191 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1229756004192 cell division protein MraZ; Reviewed; Region: PRK00326 1229756004193 MraZ protein; Region: MraZ; pfam02381 1229756004194 MraZ protein; Region: MraZ; pfam02381 1229756004195 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1229756004196 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1229756004197 DAK2 domain; Region: Dak2; pfam02734 1229756004198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1229756004199 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1229756004200 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1229756004201 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1229756004202 catalytic residues [active] 1229756004203 Thiamine pyrophosphokinase; Region: TPK; cd07995 1229756004204 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1229756004205 active site 1229756004206 dimerization interface [polypeptide binding]; other site 1229756004207 thiamine binding site [chemical binding]; other site 1229756004208 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1229756004209 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1229756004210 substrate binding site [chemical binding]; other site 1229756004211 hexamer interface [polypeptide binding]; other site 1229756004212 metal binding site [ion binding]; metal-binding site 1229756004213 GTPase RsgA; Reviewed; Region: PRK00098 1229756004214 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1229756004215 RNA binding site [nucleotide binding]; other site 1229756004216 homodimer interface [polypeptide binding]; other site 1229756004217 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1229756004218 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1229756004219 GTP/Mg2+ binding site [chemical binding]; other site 1229756004220 G4 box; other site 1229756004221 G5 box; other site 1229756004222 G1 box; other site 1229756004223 Switch I region; other site 1229756004224 G2 box; other site 1229756004225 G3 box; other site 1229756004226 Switch II region; other site 1229756004227 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1229756004228 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1229756004229 active site 1229756004230 ATP binding site [chemical binding]; other site 1229756004231 substrate binding site [chemical binding]; other site 1229756004232 activation loop (A-loop); other site 1229756004233 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1229756004234 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1229756004235 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1229756004236 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1229756004237 active site 1229756004238 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1229756004239 NusB family; Region: NusB; pfam01029 1229756004240 putative RNA binding site [nucleotide binding]; other site 1229756004241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756004242 S-adenosylmethionine binding site [chemical binding]; other site 1229756004243 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1229756004244 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1229756004245 putative active site [active] 1229756004246 substrate binding site [chemical binding]; other site 1229756004247 putative cosubstrate binding site; other site 1229756004248 catalytic site [active] 1229756004249 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1229756004250 substrate binding site [chemical binding]; other site 1229756004251 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1229756004252 hypothetical protein; Provisional; Region: PHA02941 1229756004253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756004254 ATP binding site [chemical binding]; other site 1229756004255 putative Mg++ binding site [ion binding]; other site 1229756004256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756004257 ATP-binding site [chemical binding]; other site 1229756004258 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1229756004259 G1 box; other site 1229756004260 GTP/Mg2+ binding site [chemical binding]; other site 1229756004261 Switch I region; other site 1229756004262 G2 box; other site 1229756004263 G3 box; other site 1229756004264 Switch II region; other site 1229756004265 G4 box; other site 1229756004266 G5 box; other site 1229756004267 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1229756004268 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1229756004269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756004270 Walker A motif; other site 1229756004271 ATP binding site [chemical binding]; other site 1229756004272 Walker B motif; other site 1229756004273 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1229756004274 trigger factor; Provisional; Region: tig; PRK01490 1229756004275 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1229756004276 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1229756004277 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1229756004278 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1229756004279 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 1229756004280 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1229756004281 tetramer interface [polypeptide binding]; other site 1229756004282 putative DNA binding site [nucleotide binding]; other site 1229756004283 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 1229756004284 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1229756004285 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1229756004286 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1229756004287 DpnII restriction endonuclease; Region: DpnII; pfam04556 1229756004288 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1229756004289 acetoin reductases; Region: 23BDH; TIGR02415 1229756004290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756004291 NAD(P) binding site [chemical binding]; other site 1229756004292 active site 1229756004293 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1229756004294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756004295 active site 1229756004296 nucleotide binding site [chemical binding]; other site 1229756004297 HIGH motif; other site 1229756004298 KMSKS motif; other site 1229756004299 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1229756004300 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1229756004301 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1229756004302 SelR domain; Region: SelR; pfam01641 1229756004303 dipeptidase PepV; Reviewed; Region: PRK07318 1229756004304 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1229756004305 active site 1229756004306 metal binding site [ion binding]; metal-binding site 1229756004307 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1229756004308 putative substrate binding site [chemical binding]; other site 1229756004309 putative ATP binding site [chemical binding]; other site 1229756004310 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1229756004311 active site 1229756004312 putative catalytic site [active] 1229756004313 DNA binding site [nucleotide binding] 1229756004314 putative phosphate binding site [ion binding]; other site 1229756004315 metal binding site A [ion binding]; metal-binding site 1229756004316 AP binding site [nucleotide binding]; other site 1229756004317 metal binding site B [ion binding]; metal-binding site 1229756004318 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1229756004319 active site 1229756004320 catalytic site [active] 1229756004321 substrate binding site [chemical binding]; other site 1229756004322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756004323 Coenzyme A binding pocket [chemical binding]; other site 1229756004324 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1229756004325 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1229756004326 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1229756004327 active site 1229756004328 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1229756004329 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1229756004330 homodimer interface [polypeptide binding]; other site 1229756004331 NAD binding pocket [chemical binding]; other site 1229756004332 ATP binding pocket [chemical binding]; other site 1229756004333 Mg binding site [ion binding]; other site 1229756004334 active-site loop [active] 1229756004335 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1229756004336 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1229756004337 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1229756004338 protein binding site [polypeptide binding]; other site 1229756004339 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1229756004340 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1229756004341 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1229756004342 active site 1229756004343 (T/H)XGH motif; other site 1229756004344 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1229756004345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756004346 S-adenosylmethionine binding site [chemical binding]; other site 1229756004347 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1229756004348 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1229756004349 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1229756004350 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1229756004351 oligomer interface [polypeptide binding]; other site 1229756004352 active site 1229756004353 metal binding site [ion binding]; metal-binding site 1229756004354 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756004355 catalytic core [active] 1229756004356 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756004357 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1229756004358 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1229756004359 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1229756004360 Walker A/P-loop; other site 1229756004361 ATP binding site [chemical binding]; other site 1229756004362 Q-loop/lid; other site 1229756004363 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1229756004364 ABC transporter signature motif; other site 1229756004365 Walker B; other site 1229756004366 D-loop; other site 1229756004367 H-loop/switch region; other site 1229756004368 Arginine repressor [Transcription]; Region: ArgR; COG1438 1229756004369 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1229756004370 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1229756004371 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1229756004372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1229756004373 RNA binding surface [nucleotide binding]; other site 1229756004374 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1229756004375 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1229756004376 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1229756004377 substrate binding pocket [chemical binding]; other site 1229756004378 chain length determination region; other site 1229756004379 catalytic residues [active] 1229756004380 aspartate-rich region 1; other site 1229756004381 substrate-Mg2+ binding site; other site 1229756004382 active site lid residues [active] 1229756004383 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1229756004384 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1229756004385 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1229756004386 generic binding surface II; other site 1229756004387 generic binding surface I; other site 1229756004388 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1229756004389 putative dimer interface [polypeptide binding]; other site 1229756004390 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1229756004391 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1229756004392 putative dimer interface [polypeptide binding]; other site 1229756004393 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1229756004394 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1229756004395 nucleotide binding pocket [chemical binding]; other site 1229756004396 K-X-D-G motif; other site 1229756004397 catalytic site [active] 1229756004398 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1229756004399 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1229756004400 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1229756004401 Dimer interface [polypeptide binding]; other site 1229756004402 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1229756004403 Part of AAA domain; Region: AAA_19; pfam13245 1229756004404 Family description; Region: UvrD_C_2; pfam13538 1229756004405 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1229756004406 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1229756004407 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1229756004408 Walker A/P-loop; other site 1229756004409 ATP binding site [chemical binding]; other site 1229756004410 Q-loop/lid; other site 1229756004411 ABC transporter signature motif; other site 1229756004412 Walker B; other site 1229756004413 D-loop; other site 1229756004414 H-loop/switch region; other site 1229756004415 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1229756004416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756004417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756004418 Walker A/P-loop; other site 1229756004419 ATP binding site [chemical binding]; other site 1229756004420 Q-loop/lid; other site 1229756004421 ABC transporter signature motif; other site 1229756004422 Walker B; other site 1229756004423 D-loop; other site 1229756004424 H-loop/switch region; other site 1229756004425 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1229756004426 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1229756004427 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1229756004428 hypothetical protein; Provisional; Region: PRK13678 1229756004429 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1229756004430 hypothetical protein; Provisional; Region: PRK05473 1229756004431 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1229756004432 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1229756004433 motif 1; other site 1229756004434 active site 1229756004435 motif 2; other site 1229756004436 motif 3; other site 1229756004437 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1229756004438 DHHA1 domain; Region: DHHA1; pfam02272 1229756004439 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1229756004440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1229756004441 inhibitor-cofactor binding pocket; inhibition site 1229756004442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756004443 catalytic residue [active] 1229756004444 amino acid transporter; Region: 2A0306; TIGR00909 1229756004445 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1229756004446 GntP family permease; Region: GntP_permease; pfam02447 1229756004447 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1229756004448 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1229756004449 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1229756004450 N- and C-terminal domain interface [polypeptide binding]; other site 1229756004451 active site 1229756004452 catalytic site [active] 1229756004453 metal binding site [ion binding]; metal-binding site 1229756004454 carbohydrate binding site [chemical binding]; other site 1229756004455 ATP binding site [chemical binding]; other site 1229756004456 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1229756004457 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1229756004458 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1229756004459 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1229756004460 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1229756004461 putative active site [active] 1229756004462 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1229756004463 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1229756004464 Sugar specificity; other site 1229756004465 Pyrimidine base specificity; other site 1229756004466 ATP-binding site [chemical binding]; other site 1229756004467 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1229756004468 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1229756004469 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1229756004470 catalytic triad [active] 1229756004471 catalytic triad [active] 1229756004472 oxyanion hole [active] 1229756004473 catabolite control protein A; Region: ccpA; TIGR01481 1229756004474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756004475 DNA binding site [nucleotide binding] 1229756004476 domain linker motif; other site 1229756004477 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1229756004478 dimerization interface [polypeptide binding]; other site 1229756004479 effector binding site; other site 1229756004480 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1229756004481 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1229756004482 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1229756004483 active site 1229756004484 CAAX protease self-immunity; Region: Abi; pfam02517 1229756004485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756004486 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1229756004487 active site 1229756004488 motif I; other site 1229756004489 motif II; other site 1229756004490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1229756004491 hypothetical protein; Provisional; Region: PRK04351 1229756004492 SprT homologues; Region: SprT; cl01182 1229756004493 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1229756004494 acyl carrier protein; Provisional; Region: acpP; PRK00982 1229756004495 putative phosphate acyltransferase; Provisional; Region: PRK05331 1229756004496 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1229756004497 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1229756004498 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1229756004499 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1229756004500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756004501 Zn2+ binding site [ion binding]; other site 1229756004502 Mg2+ binding site [ion binding]; other site 1229756004503 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1229756004504 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 1229756004505 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1229756004506 benzoate transport; Region: 2A0115; TIGR00895 1229756004507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756004508 putative substrate translocation pore; other site 1229756004509 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1229756004510 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1229756004511 Zn binding site [ion binding]; other site 1229756004512 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1229756004513 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1229756004514 putative ligand binding site [chemical binding]; other site 1229756004515 putative NAD binding site [chemical binding]; other site 1229756004516 catalytic site [active] 1229756004517 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1229756004518 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1229756004519 substrate binding site [chemical binding]; other site 1229756004520 ATP binding site [chemical binding]; other site 1229756004521 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1229756004522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756004523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756004524 DNA binding site [nucleotide binding] 1229756004525 domain linker motif; other site 1229756004526 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1229756004527 putative dimerization interface [polypeptide binding]; other site 1229756004528 putative ligand binding site [chemical binding]; other site 1229756004529 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1229756004530 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1229756004531 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1229756004532 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1229756004533 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756004534 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1229756004535 active site 1229756004536 catalytic site [active] 1229756004537 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1229756004538 peroxiredoxin; Region: AhpC; TIGR03137 1229756004539 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1229756004540 dimer interface [polypeptide binding]; other site 1229756004541 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1229756004542 catalytic triad [active] 1229756004543 peroxidatic and resolving cysteines [active] 1229756004544 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1229756004545 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1229756004546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756004547 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1229756004548 catalytic residue [active] 1229756004549 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1229756004550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1229756004551 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1229756004552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1229756004553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756004554 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1229756004555 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1229756004556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1229756004557 E3 interaction surface; other site 1229756004558 lipoyl attachment site [posttranslational modification]; other site 1229756004559 e3 binding domain; Region: E3_binding; pfam02817 1229756004560 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1229756004561 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1229756004562 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1229756004563 alpha subunit interface [polypeptide binding]; other site 1229756004564 TPP binding site [chemical binding]; other site 1229756004565 heterodimer interface [polypeptide binding]; other site 1229756004566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1229756004567 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1229756004568 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1229756004569 tetramer interface [polypeptide binding]; other site 1229756004570 TPP-binding site [chemical binding]; other site 1229756004571 heterodimer interface [polypeptide binding]; other site 1229756004572 phosphorylation loop region [posttranslational modification] 1229756004573 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1229756004574 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1229756004575 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1229756004576 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1229756004577 active site residue [active] 1229756004578 adaptor protein; Provisional; Region: PRK02315 1229756004579 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1229756004580 ArsC family; Region: ArsC; pfam03960 1229756004581 putative catalytic residues [active] 1229756004582 thiol/disulfide switch; other site 1229756004583 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1229756004584 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1229756004585 RNA binding site [nucleotide binding]; other site 1229756004586 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1229756004587 active site 1229756004588 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1229756004589 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1229756004590 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1229756004591 catalytic site [active] 1229756004592 G-X2-G-X-G-K; other site 1229756004593 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1229756004594 phosphodiesterase; Provisional; Region: PRK12704 1229756004595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756004596 Zn2+ binding site [ion binding]; other site 1229756004597 Mg2+ binding site [ion binding]; other site 1229756004598 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1229756004599 SmpB-tmRNA interface; other site 1229756004600 ribonuclease R; Region: RNase_R; TIGR02063 1229756004601 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1229756004602 RNB domain; Region: RNB; pfam00773 1229756004603 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1229756004604 RNA binding site [nucleotide binding]; other site 1229756004605 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1229756004606 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1229756004607 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1229756004608 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1229756004609 OxaA-like protein precursor; Provisional; Region: PRK02463 1229756004610 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1229756004611 Acylphosphatase; Region: Acylphosphatase; pfam00708 1229756004612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1229756004613 HAMP domain; Region: HAMP; pfam00672 1229756004614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1229756004615 dimer interface [polypeptide binding]; other site 1229756004616 phosphorylation site [posttranslational modification] 1229756004617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756004618 ATP binding site [chemical binding]; other site 1229756004619 Mg2+ binding site [ion binding]; other site 1229756004620 G-X-G motif; other site 1229756004621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756004622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756004623 active site 1229756004624 phosphorylation site [posttranslational modification] 1229756004625 intermolecular recognition site; other site 1229756004626 dimerization interface [polypeptide binding]; other site 1229756004627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756004628 DNA binding site [nucleotide binding] 1229756004629 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1229756004630 hypothetical protein; Provisional; Region: PRK13670 1229756004631 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1229756004632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756004633 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1229756004634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756004635 Zn2+ binding site [ion binding]; other site 1229756004636 Mg2+ binding site [ion binding]; other site 1229756004637 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1229756004638 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1229756004639 active site 1229756004640 (T/H)XGH motif; other site 1229756004641 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1229756004642 GTPase YqeH; Provisional; Region: PRK13796 1229756004643 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1229756004644 GTP/Mg2+ binding site [chemical binding]; other site 1229756004645 G4 box; other site 1229756004646 G5 box; other site 1229756004647 G1 box; other site 1229756004648 Switch I region; other site 1229756004649 G2 box; other site 1229756004650 G3 box; other site 1229756004651 Switch II region; other site 1229756004652 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1229756004653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756004654 active site 1229756004655 motif I; other site 1229756004656 motif II; other site 1229756004657 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1229756004658 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1229756004659 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1229756004660 D-lactate dehydrogenase; Validated; Region: PRK08605 1229756004661 homodimer interface [polypeptide binding]; other site 1229756004662 ligand binding site [chemical binding]; other site 1229756004663 NAD binding site [chemical binding]; other site 1229756004664 catalytic site [active] 1229756004665 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1229756004666 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1229756004667 oligomer interface [polypeptide binding]; other site 1229756004668 active site residues [active] 1229756004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1229756004670 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1229756004671 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1229756004672 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1229756004673 phosphate binding site [ion binding]; other site 1229756004674 putative substrate binding pocket [chemical binding]; other site 1229756004675 dimer interface [polypeptide binding]; other site 1229756004676 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1229756004677 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1229756004678 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1229756004679 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1229756004680 excinuclease ABC subunit B; Provisional; Region: PRK05298 1229756004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756004682 ATP binding site [chemical binding]; other site 1229756004683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756004684 nucleotide binding region [chemical binding]; other site 1229756004685 ATP-binding site [chemical binding]; other site 1229756004686 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1229756004687 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1229756004688 Sulfatase; Region: Sulfatase; pfam00884 1229756004689 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1229756004690 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1229756004691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1229756004692 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1229756004693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1229756004694 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1229756004695 putative ADP-binding pocket [chemical binding]; other site 1229756004696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1229756004697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756004698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756004699 Walker A/P-loop; other site 1229756004700 ATP binding site [chemical binding]; other site 1229756004701 Q-loop/lid; other site 1229756004702 ABC transporter signature motif; other site 1229756004703 Walker B; other site 1229756004704 D-loop; other site 1229756004705 H-loop/switch region; other site 1229756004706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1229756004707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1229756004708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756004709 Walker A/P-loop; other site 1229756004710 ATP binding site [chemical binding]; other site 1229756004711 Q-loop/lid; other site 1229756004712 ABC transporter signature motif; other site 1229756004713 Walker B; other site 1229756004714 D-loop; other site 1229756004715 H-loop/switch region; other site 1229756004716 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1229756004717 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756004718 Walker A/P-loop; other site 1229756004719 ATP binding site [chemical binding]; other site 1229756004720 Q-loop/lid; other site 1229756004721 ABC transporter signature motif; other site 1229756004722 Walker B; other site 1229756004723 D-loop; other site 1229756004724 H-loop/switch region; other site 1229756004725 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1229756004726 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1229756004727 FtsX-like permease family; Region: FtsX; pfam02687 1229756004728 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1229756004729 nudix motif; other site 1229756004730 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756004731 Zn2+ binding site [ion binding]; other site 1229756004732 Mg2+ binding site [ion binding]; other site 1229756004733 Predicted integral membrane protein [Function unknown]; Region: COG0392 1229756004734 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1229756004735 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1229756004736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1229756004737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1229756004738 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 1229756004739 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1229756004740 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1229756004741 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1229756004742 MPN+ (JAMM) motif; other site 1229756004743 Zinc-binding site [ion binding]; other site 1229756004744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756004745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756004746 putative substrate translocation pore; other site 1229756004747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1229756004748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756004749 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1229756004750 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1229756004751 ATP binding site [chemical binding]; other site 1229756004752 Mg++ binding site [ion binding]; other site 1229756004753 motif III; other site 1229756004754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756004755 nucleotide binding region [chemical binding]; other site 1229756004756 ATP-binding site [chemical binding]; other site 1229756004757 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1229756004758 Beta-lactamase; Region: Beta-lactamase; pfam00144 1229756004759 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1229756004760 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1229756004761 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1229756004762 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1229756004763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756004764 S-adenosylmethionine binding site [chemical binding]; other site 1229756004765 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1229756004766 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1229756004767 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1229756004768 hinge; other site 1229756004769 active site 1229756004770 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1229756004771 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1229756004772 putative tRNA-binding site [nucleotide binding]; other site 1229756004773 B3/4 domain; Region: B3_4; pfam03483 1229756004774 tRNA synthetase B5 domain; Region: B5; smart00874 1229756004775 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1229756004776 dimer interface [polypeptide binding]; other site 1229756004777 motif 1; other site 1229756004778 motif 3; other site 1229756004779 motif 2; other site 1229756004780 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1229756004781 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1229756004782 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1229756004783 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1229756004784 dimer interface [polypeptide binding]; other site 1229756004785 motif 1; other site 1229756004786 active site 1229756004787 motif 2; other site 1229756004788 motif 3; other site 1229756004789 Predicted transcriptional regulators [Transcription]; Region: COG1733 1229756004790 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1229756004791 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1229756004792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1229756004793 nucleotide binding site [chemical binding]; other site 1229756004794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1229756004795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1229756004796 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1229756004797 active site 1229756004798 metal binding site [ion binding]; metal-binding site 1229756004799 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1229756004800 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1229756004801 putative NAD(P) binding site [chemical binding]; other site 1229756004802 catalytic Zn binding site [ion binding]; other site 1229756004803 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756004804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756004805 DNA binding site [nucleotide binding] 1229756004806 domain linker motif; other site 1229756004807 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1229756004808 dimerization interface [polypeptide binding]; other site 1229756004809 ligand binding site [chemical binding]; other site 1229756004810 sodium binding site [ion binding]; other site 1229756004811 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1229756004812 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1229756004813 putative ligand binding site [chemical binding]; other site 1229756004814 putative NAD binding site [chemical binding]; other site 1229756004815 catalytic site [active] 1229756004816 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1229756004817 active site 1229756004818 catalytic motif [active] 1229756004819 Zn binding site [ion binding]; other site 1229756004820 oligoendopeptidase F; Region: pepF; TIGR00181 1229756004821 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1229756004822 active site 1229756004823 Zn binding site [ion binding]; other site 1229756004824 Competence protein CoiA-like family; Region: CoiA; cl11541 1229756004825 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756004826 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756004827 substrate binding pocket [chemical binding]; other site 1229756004828 membrane-bound complex binding site; other site 1229756004829 hinge residues; other site 1229756004830 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1229756004831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756004832 dimer interface [polypeptide binding]; other site 1229756004833 conserved gate region; other site 1229756004834 putative PBP binding loops; other site 1229756004835 ABC-ATPase subunit interface; other site 1229756004836 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1229756004837 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1229756004838 Walker A/P-loop; other site 1229756004839 ATP binding site [chemical binding]; other site 1229756004840 Q-loop/lid; other site 1229756004841 ABC transporter signature motif; other site 1229756004842 Walker B; other site 1229756004843 D-loop; other site 1229756004844 H-loop/switch region; other site 1229756004845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1229756004846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1229756004847 substrate binding pocket [chemical binding]; other site 1229756004848 membrane-bound complex binding site; other site 1229756004849 hinge residues; other site 1229756004850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756004851 dimer interface [polypeptide binding]; other site 1229756004852 conserved gate region; other site 1229756004853 putative PBP binding loops; other site 1229756004854 ABC-ATPase subunit interface; other site 1229756004855 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1229756004856 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1229756004857 ligand binding site [chemical binding]; other site 1229756004858 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1229756004859 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1229756004860 YibE/F-like protein; Region: YibE_F; pfam07907 1229756004861 YibE/F-like protein; Region: YibE_F; pfam07907 1229756004862 primosomal protein DnaI; Reviewed; Region: PRK08939 1229756004863 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1229756004864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1229756004865 Walker A motif; other site 1229756004866 ATP binding site [chemical binding]; other site 1229756004867 Walker B motif; other site 1229756004868 arginine finger; other site 1229756004869 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1229756004870 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1229756004871 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1229756004872 CoA-binding site [chemical binding]; other site 1229756004873 Protein of unknown function (DUF975); Region: DUF975; cl10504 1229756004874 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1229756004875 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1229756004876 DNA binding site [nucleotide binding] 1229756004877 catalytic residue [active] 1229756004878 H2TH interface [polypeptide binding]; other site 1229756004879 putative catalytic residues [active] 1229756004880 turnover-facilitating residue; other site 1229756004881 intercalation triad [nucleotide binding]; other site 1229756004882 8OG recognition residue [nucleotide binding]; other site 1229756004883 putative reading head residues; other site 1229756004884 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1229756004885 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1229756004886 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1229756004887 MutS domain III; Region: MutS_III; pfam05192 1229756004888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756004889 Walker A/P-loop; other site 1229756004890 ATP binding site [chemical binding]; other site 1229756004891 Q-loop/lid; other site 1229756004892 ABC transporter signature motif; other site 1229756004893 Walker B; other site 1229756004894 D-loop; other site 1229756004895 H-loop/switch region; other site 1229756004896 Smr domain; Region: Smr; pfam01713 1229756004897 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1229756004898 Colicin V production protein; Region: Colicin_V; pfam02674 1229756004899 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 1229756004900 ribonuclease HIII; Provisional; Region: PRK00996 1229756004901 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1229756004902 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1229756004903 RNA/DNA hybrid binding site [nucleotide binding]; other site 1229756004904 active site 1229756004905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756004906 NAD(P) binding site [chemical binding]; other site 1229756004907 active site 1229756004908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1229756004909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756004910 Coenzyme A binding pocket [chemical binding]; other site 1229756004911 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1229756004912 DsrE/DsrF-like family; Region: DrsE; cl00672 1229756004913 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756004914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756004915 non-specific DNA binding site [nucleotide binding]; other site 1229756004916 salt bridge; other site 1229756004917 sequence-specific DNA binding site [nucleotide binding]; other site 1229756004918 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1229756004919 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1229756004920 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1229756004921 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1229756004922 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1229756004923 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1229756004924 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1229756004925 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1229756004926 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1229756004927 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1229756004928 carboxyltransferase (CT) interaction site; other site 1229756004929 biotinylation site [posttranslational modification]; other site 1229756004930 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1229756004931 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1229756004932 dimer interface [polypeptide binding]; other site 1229756004933 active site 1229756004934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756004935 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1229756004936 NAD(P) binding site [chemical binding]; other site 1229756004937 active site 1229756004938 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1229756004939 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1229756004940 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1229756004941 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1229756004942 FMN binding site [chemical binding]; other site 1229756004943 substrate binding site [chemical binding]; other site 1229756004944 putative catalytic residue [active] 1229756004945 acyl carrier protein; Provisional; Region: acpP; PRK00982 1229756004946 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1229756004947 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1229756004948 dimer interface [polypeptide binding]; other site 1229756004949 active site 1229756004950 CoA binding pocket [chemical binding]; other site 1229756004951 MarR family; Region: MarR_2; pfam12802 1229756004952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1229756004953 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1229756004954 putative phosphoesterase; Region: acc_ester; TIGR03729 1229756004955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1229756004956 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1229756004957 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1229756004958 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1229756004959 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1229756004960 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1229756004961 active site 1229756004962 HIGH motif; other site 1229756004963 KMSKS motif; other site 1229756004964 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1229756004965 tRNA binding surface [nucleotide binding]; other site 1229756004966 anticodon binding site; other site 1229756004967 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1229756004968 dimer interface [polypeptide binding]; other site 1229756004969 putative tRNA-binding site [nucleotide binding]; other site 1229756004970 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1229756004971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756004972 Zn2+ binding site [ion binding]; other site 1229756004973 Mg2+ binding site [ion binding]; other site 1229756004974 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1229756004975 Predicted membrane protein [Function unknown]; Region: COG4640 1229756004976 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1229756004977 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1229756004978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1229756004979 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1229756004980 active site 1229756004981 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756004982 catalytic core [active] 1229756004983 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1229756004984 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1229756004985 Melibiase; Region: Melibiase; pfam02065 1229756004986 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756004987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756004988 DNA binding site [nucleotide binding] 1229756004989 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756004990 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1229756004991 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1229756004992 putative catalytic cysteine [active] 1229756004993 gamma-glutamyl kinase; Provisional; Region: PRK05429 1229756004994 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1229756004995 nucleotide binding site [chemical binding]; other site 1229756004996 homotetrameric interface [polypeptide binding]; other site 1229756004997 putative phosphate binding site [ion binding]; other site 1229756004998 putative allosteric binding site; other site 1229756004999 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1229756005000 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1229756005001 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1229756005002 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1229756005003 active site 1229756005004 Zn binding site [ion binding]; other site 1229756005005 Domain of unknown function (DUF368); Region: DUF368; cl00893 1229756005006 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1229756005007 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1229756005008 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1229756005009 Predicted membrane protein [Function unknown]; Region: COG4709 1229756005010 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756005011 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1229756005012 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1229756005013 thiamine phosphate binding site [chemical binding]; other site 1229756005014 active site 1229756005015 pyrophosphate binding site [ion binding]; other site 1229756005016 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1229756005017 dimer interface [polypeptide binding]; other site 1229756005018 substrate binding site [chemical binding]; other site 1229756005019 ATP binding site [chemical binding]; other site 1229756005020 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1229756005021 substrate binding site [chemical binding]; other site 1229756005022 multimerization interface [polypeptide binding]; other site 1229756005023 ATP binding site [chemical binding]; other site 1229756005024 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1229756005025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1229756005026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756005027 Walker A motif; other site 1229756005028 ATP binding site [chemical binding]; other site 1229756005029 Walker B motif; other site 1229756005030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756005031 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1229756005032 NAD(P) binding site [chemical binding]; other site 1229756005033 active site 1229756005034 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1229756005035 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1229756005036 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1229756005037 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1229756005038 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1229756005039 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1229756005040 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1229756005041 Sugar transport protein; Region: Sugar_transport; pfam06800 1229756005042 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1229756005043 dimerization interface [polypeptide binding]; other site 1229756005044 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1229756005045 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1229756005046 propionate/acetate kinase; Provisional; Region: PRK12379 1229756005047 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1229756005048 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1229756005049 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1229756005050 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1229756005051 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1229756005052 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1229756005053 Type II/IV secretion system protein; Region: T2SE; pfam00437 1229756005054 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1229756005055 Walker A motif; other site 1229756005056 ATP binding site [chemical binding]; other site 1229756005057 Walker B motif; other site 1229756005058 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1229756005059 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1229756005060 active site 1229756005061 dimer interface [polypeptide binding]; other site 1229756005062 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1229756005063 dimer interface [polypeptide binding]; other site 1229756005064 active site 1229756005065 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1229756005066 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1229756005067 active site 1229756005068 trimer interface [polypeptide binding]; other site 1229756005069 allosteric site; other site 1229756005070 active site lid [active] 1229756005071 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1229756005072 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1229756005073 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1229756005074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1229756005075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1229756005076 dimer interface [polypeptide binding]; other site 1229756005077 phosphorylation site [posttranslational modification] 1229756005078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1229756005079 ATP binding site [chemical binding]; other site 1229756005080 Mg2+ binding site [ion binding]; other site 1229756005081 G-X-G motif; other site 1229756005082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1229756005083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1229756005084 active site 1229756005085 phosphorylation site [posttranslational modification] 1229756005086 intermolecular recognition site; other site 1229756005087 dimerization interface [polypeptide binding]; other site 1229756005088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1229756005089 DNA binding site [nucleotide binding] 1229756005090 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1229756005091 GTP-binding protein YchF; Reviewed; Region: PRK09601 1229756005092 YchF GTPase; Region: YchF; cd01900 1229756005093 G1 box; other site 1229756005094 GTP/Mg2+ binding site [chemical binding]; other site 1229756005095 Switch I region; other site 1229756005096 G2 box; other site 1229756005097 Switch II region; other site 1229756005098 G3 box; other site 1229756005099 G4 box; other site 1229756005100 G5 box; other site 1229756005101 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1229756005102 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1229756005103 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1229756005104 ParB-like nuclease domain; Region: ParB; smart00470 1229756005105 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1229756005106 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1229756005107 P-loop; other site 1229756005108 Magnesium ion binding site [ion binding]; other site 1229756005109 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1229756005110 Magnesium ion binding site [ion binding]; other site 1229756005111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1229756005112 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1229756005113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756005114 S-adenosylmethionine binding site [chemical binding]; other site 1229756005115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756005116 dimerization interface [polypeptide binding]; other site 1229756005117 putative DNA binding site [nucleotide binding]; other site 1229756005118 putative Zn2+ binding site [ion binding]; other site 1229756005119 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1229756005120 Ligand Binding Site [chemical binding]; other site 1229756005121 manganese transport protein MntH; Reviewed; Region: PRK00701 1229756005122 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1229756005123 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1229756005124 NAD-dependent deacetylase; Provisional; Region: PRK00481 1229756005125 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1229756005126 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1229756005127 nucleophile elbow; other site 1229756005128 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1229756005129 homodimer interface [polypeptide binding]; other site 1229756005130 catalytic residues [active] 1229756005131 NAD binding site [chemical binding]; other site 1229756005132 substrate binding pocket [chemical binding]; other site 1229756005133 flexible flap; other site 1229756005134 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1229756005135 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1229756005136 Protein of unknown function (DUF454); Region: DUF454; cl01063 1229756005137 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1229756005138 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1229756005139 active site 1229756005140 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1229756005141 FemAB family; Region: FemAB; pfam02388 1229756005142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756005143 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756005144 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1229756005145 NlpC/P60 family; Region: NLPC_P60; cl17555 1229756005146 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1229756005147 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756005148 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756005149 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1229756005150 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1229756005151 dimer interface [polypeptide binding]; other site 1229756005152 active site 1229756005153 CoA binding pocket [chemical binding]; other site 1229756005154 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1229756005155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1229756005156 active site 1229756005157 HIGH motif; other site 1229756005158 nucleotide binding site [chemical binding]; other site 1229756005159 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1229756005160 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1229756005161 active site 1229756005162 KMSKS motif; other site 1229756005163 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1229756005164 tRNA binding surface [nucleotide binding]; other site 1229756005165 anticodon binding site; other site 1229756005166 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1229756005167 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1229756005168 PemK-like protein; Region: PemK; pfam02452 1229756005169 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1229756005170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1229756005171 active site 1229756005172 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1229756005173 dimer interface [polypeptide binding]; other site 1229756005174 substrate binding site [chemical binding]; other site 1229756005175 catalytic residues [active] 1229756005176 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1229756005177 potential frameshift: common BLAST hit: gi|300173961|ref|YP_003773127.1| membrane spanning protein 1229756005178 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1229756005179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756005181 homodimer interface [polypeptide binding]; other site 1229756005182 catalytic residue [active] 1229756005183 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1229756005184 active site 1229756005185 amino acid transporter; Region: 2A0306; TIGR00909 1229756005186 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1229756005187 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1229756005188 30S subunit binding site; other site 1229756005189 comF family protein; Region: comF; TIGR00201 1229756005190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756005191 active site 1229756005192 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1229756005193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1229756005194 ATP binding site [chemical binding]; other site 1229756005195 putative Mg++ binding site [ion binding]; other site 1229756005196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1229756005197 nucleotide binding region [chemical binding]; other site 1229756005198 ATP-binding site [chemical binding]; other site 1229756005199 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1229756005200 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1229756005201 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1229756005202 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1229756005203 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1229756005204 polyphosphate kinase; Provisional; Region: PRK05443 1229756005205 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1229756005206 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1229756005207 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1229756005208 putative domain interface [polypeptide binding]; other site 1229756005209 putative active site [active] 1229756005210 catalytic site [active] 1229756005211 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1229756005212 putative domain interface [polypeptide binding]; other site 1229756005213 putative active site [active] 1229756005214 catalytic site [active] 1229756005215 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1229756005216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1229756005217 Zn2+ binding site [ion binding]; other site 1229756005218 Mg2+ binding site [ion binding]; other site 1229756005219 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1229756005220 enolase; Provisional; Region: eno; PRK00077 1229756005221 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1229756005222 dimer interface [polypeptide binding]; other site 1229756005223 metal binding site [ion binding]; metal-binding site 1229756005224 substrate binding pocket [chemical binding]; other site 1229756005225 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1229756005226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1229756005227 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1229756005228 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1229756005229 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1229756005230 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1229756005231 active site 1229756005232 metal binding site [ion binding]; metal-binding site 1229756005233 dimerization interface [polypeptide binding]; other site 1229756005234 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1229756005235 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1229756005236 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1229756005237 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1229756005238 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1229756005239 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1229756005240 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1229756005241 DNA binding site [nucleotide binding] 1229756005242 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1229756005243 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1229756005244 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1229756005245 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1229756005246 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1229756005247 RPB1 interaction site [polypeptide binding]; other site 1229756005248 RPB10 interaction site [polypeptide binding]; other site 1229756005249 RPB11 interaction site [polypeptide binding]; other site 1229756005250 RPB3 interaction site [polypeptide binding]; other site 1229756005251 RPB12 interaction site [polypeptide binding]; other site 1229756005252 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1229756005253 triosephosphate isomerase; Provisional; Region: PRK14565 1229756005254 substrate binding site [chemical binding]; other site 1229756005255 dimer interface [polypeptide binding]; other site 1229756005256 catalytic triad [active] 1229756005257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756005258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756005259 non-specific DNA binding site [nucleotide binding]; other site 1229756005260 salt bridge; other site 1229756005261 sequence-specific DNA binding site [nucleotide binding]; other site 1229756005262 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1229756005263 DNA-binding site [nucleotide binding]; DNA binding site 1229756005264 RNA-binding motif; other site 1229756005265 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756005266 catalytic core [active] 1229756005267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756005268 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1229756005269 active site 1229756005270 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1229756005271 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1229756005272 dimer interface [polypeptide binding]; other site 1229756005273 putative radical transfer pathway; other site 1229756005274 diiron center [ion binding]; other site 1229756005275 tyrosyl radical; other site 1229756005276 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1229756005277 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1229756005278 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1229756005279 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1229756005280 active site 1229756005281 dimer interface [polypeptide binding]; other site 1229756005282 catalytic residues [active] 1229756005283 effector binding site; other site 1229756005284 R2 peptide binding site; other site 1229756005285 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1229756005286 catalytic residues [active] 1229756005287 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1229756005288 Domain of unknown function DUF21; Region: DUF21; pfam01595 1229756005289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1229756005290 Transporter associated domain; Region: CorC_HlyC; smart01091 1229756005291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1229756005292 catalytic core [active] 1229756005293 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1229756005294 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1229756005295 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1229756005296 HflX GTPase family; Region: HflX; cd01878 1229756005297 G1 box; other site 1229756005298 GTP/Mg2+ binding site [chemical binding]; other site 1229756005299 Switch I region; other site 1229756005300 G2 box; other site 1229756005301 G3 box; other site 1229756005302 Switch II region; other site 1229756005303 G4 box; other site 1229756005304 G5 box; other site 1229756005305 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1229756005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756005308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005309 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1229756005310 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1229756005311 23S rRNA interface [nucleotide binding]; other site 1229756005312 L3 interface [polypeptide binding]; other site 1229756005313 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1229756005314 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1229756005315 dimerization interface 3.5A [polypeptide binding]; other site 1229756005316 active site 1229756005317 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1229756005318 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1229756005319 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756005320 Walker A/P-loop; other site 1229756005321 ATP binding site [chemical binding]; other site 1229756005322 Q-loop/lid; other site 1229756005323 ABC transporter signature motif; other site 1229756005324 Walker B; other site 1229756005325 D-loop; other site 1229756005326 H-loop/switch region; other site 1229756005327 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1229756005328 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1229756005329 Walker A/P-loop; other site 1229756005330 ATP binding site [chemical binding]; other site 1229756005331 Q-loop/lid; other site 1229756005332 ABC transporter signature motif; other site 1229756005333 Walker B; other site 1229756005334 D-loop; other site 1229756005335 H-loop/switch region; other site 1229756005336 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1229756005337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756005338 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1229756005339 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1229756005340 substrate binding pocket [chemical binding]; other site 1229756005341 chain length determination region; other site 1229756005342 substrate-Mg2+ binding site; other site 1229756005343 catalytic residues [active] 1229756005344 aspartate-rich region 1; other site 1229756005345 active site lid residues [active] 1229756005346 aspartate-rich region 2; other site 1229756005347 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1229756005348 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1229756005349 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1229756005350 alphaNTD - beta interaction site [polypeptide binding]; other site 1229756005351 alphaNTD homodimer interface [polypeptide binding]; other site 1229756005352 alphaNTD - beta' interaction site [polypeptide binding]; other site 1229756005353 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1229756005354 30S ribosomal protein S11; Validated; Region: PRK05309 1229756005355 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1229756005356 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1229756005357 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1229756005358 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1229756005359 rRNA binding site [nucleotide binding]; other site 1229756005360 predicted 30S ribosome binding site; other site 1229756005361 adenylate kinase; Reviewed; Region: adk; PRK00279 1229756005362 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1229756005363 AMP-binding site [chemical binding]; other site 1229756005364 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1229756005365 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1229756005366 SecY translocase; Region: SecY; pfam00344 1229756005367 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1229756005368 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 1229756005369 23S rRNA binding site - archaea [nucleotide binding]; other site 1229756005370 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 1229756005371 5S rRNA binding site - archaea; other site 1229756005372 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1229756005373 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1229756005374 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1229756005375 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1229756005376 5S rRNA interface [nucleotide binding]; other site 1229756005377 L27 interface [polypeptide binding]; other site 1229756005378 23S rRNA interface [nucleotide binding]; other site 1229756005379 L5 interface [polypeptide binding]; other site 1229756005380 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1229756005381 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1229756005382 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1229756005383 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1229756005384 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1229756005385 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1229756005386 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1229756005387 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1229756005388 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1229756005389 RNA binding site [nucleotide binding]; other site 1229756005390 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1229756005391 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1229756005392 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1229756005393 putative translocon interaction site; other site 1229756005394 23S rRNA interface [nucleotide binding]; other site 1229756005395 signal recognition particle (SRP54) interaction site; other site 1229756005396 L23 interface [polypeptide binding]; other site 1229756005397 trigger factor interaction site; other site 1229756005398 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1229756005399 23S rRNA interface [nucleotide binding]; other site 1229756005400 5S rRNA interface [nucleotide binding]; other site 1229756005401 putative antibiotic binding site [chemical binding]; other site 1229756005402 L25 interface [polypeptide binding]; other site 1229756005403 L27 interface [polypeptide binding]; other site 1229756005404 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1229756005405 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1229756005406 G-X-X-G motif; other site 1229756005407 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1229756005408 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1229756005409 putative translocon binding site; other site 1229756005410 protein-rRNA interface [nucleotide binding]; other site 1229756005411 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1229756005412 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1229756005413 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1229756005414 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1229756005415 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1229756005416 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1229756005417 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1229756005418 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1229756005419 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1229756005420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1229756005421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1229756005422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756005423 dimer interface [polypeptide binding]; other site 1229756005424 conserved gate region; other site 1229756005425 ABC-ATPase subunit interface; other site 1229756005426 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1229756005427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756005428 dimer interface [polypeptide binding]; other site 1229756005429 conserved gate region; other site 1229756005430 putative PBP binding loops; other site 1229756005431 ABC-ATPase subunit interface; other site 1229756005432 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1229756005433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756005434 Walker A/P-loop; other site 1229756005435 ATP binding site [chemical binding]; other site 1229756005436 Q-loop/lid; other site 1229756005437 ABC transporter signature motif; other site 1229756005438 Walker B; other site 1229756005439 D-loop; other site 1229756005440 H-loop/switch region; other site 1229756005441 TOBE domain; Region: TOBE_2; pfam08402 1229756005442 cyanate transporter; Region: CynX; TIGR00896 1229756005443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005444 putative substrate translocation pore; other site 1229756005445 elongation factor G; Reviewed; Region: PRK12739 1229756005446 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1229756005447 G1 box; other site 1229756005448 putative GEF interaction site [polypeptide binding]; other site 1229756005449 GTP/Mg2+ binding site [chemical binding]; other site 1229756005450 Switch I region; other site 1229756005451 G2 box; other site 1229756005452 G3 box; other site 1229756005453 Switch II region; other site 1229756005454 G4 box; other site 1229756005455 G5 box; other site 1229756005456 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1229756005457 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1229756005458 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1229756005459 30S ribosomal protein S7; Validated; Region: PRK05302 1229756005460 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1229756005461 S17 interaction site [polypeptide binding]; other site 1229756005462 S8 interaction site; other site 1229756005463 16S rRNA interaction site [nucleotide binding]; other site 1229756005464 streptomycin interaction site [chemical binding]; other site 1229756005465 23S rRNA interaction site [nucleotide binding]; other site 1229756005466 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1229756005467 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1229756005468 Clp amino terminal domain; Region: Clp_N; pfam02861 1229756005469 Clp amino terminal domain; Region: Clp_N; pfam02861 1229756005470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756005471 Walker A motif; other site 1229756005472 ATP binding site [chemical binding]; other site 1229756005473 Walker B motif; other site 1229756005474 arginine finger; other site 1229756005475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1229756005476 Walker A motif; other site 1229756005477 ATP binding site [chemical binding]; other site 1229756005478 Walker B motif; other site 1229756005479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1229756005480 peptide chain release factor 2; Provisional; Region: PRK05589 1229756005481 PCRF domain; Region: PCRF; pfam03462 1229756005482 RF-1 domain; Region: RF-1; pfam00472 1229756005483 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1229756005484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1229756005485 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1229756005486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1229756005487 nucleotide binding region [chemical binding]; other site 1229756005488 ATP-binding site [chemical binding]; other site 1229756005489 seryl-tRNA synthetase; Provisional; Region: PRK05431 1229756005490 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1229756005491 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1229756005492 dimer interface [polypeptide binding]; other site 1229756005493 active site 1229756005494 motif 1; other site 1229756005495 motif 2; other site 1229756005496 motif 3; other site 1229756005497 potential protein location (hypothetical protein C269_08360 [Leuconostoc gelidum JB7]) that overlaps RNA (tRNA-S) 1229756005498 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1229756005499 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1229756005500 active site 1229756005501 HIGH motif; other site 1229756005502 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1229756005503 KMSKS motif; other site 1229756005504 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1229756005505 tRNA binding surface [nucleotide binding]; other site 1229756005506 anticodon binding site; other site 1229756005507 Phosphoglycerate kinase; Region: PGK; pfam00162 1229756005508 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1229756005509 substrate binding site [chemical binding]; other site 1229756005510 hinge regions; other site 1229756005511 ADP binding site [chemical binding]; other site 1229756005512 catalytic site [active] 1229756005513 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1229756005514 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1229756005515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1229756005516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756005518 putative substrate translocation pore; other site 1229756005519 pantothenate kinase; Provisional; Region: PRK05439 1229756005520 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1229756005521 active site 1229756005522 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1229756005523 Part of AAA domain; Region: AAA_19; pfam13245 1229756005524 Family description; Region: UvrD_C_2; pfam13538 1229756005525 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1229756005526 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1229756005527 putative active site [active] 1229756005528 putative FMN binding site [chemical binding]; other site 1229756005529 putative substrate binding site [chemical binding]; other site 1229756005530 putative catalytic residue [active] 1229756005531 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1229756005532 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1229756005533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1229756005534 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1229756005535 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1229756005536 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1229756005537 active site 1229756005538 metal binding site [ion binding]; metal-binding site 1229756005539 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1229756005540 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1229756005541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756005542 dimer interface [polypeptide binding]; other site 1229756005543 conserved gate region; other site 1229756005544 ABC-ATPase subunit interface; other site 1229756005545 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1229756005546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1229756005547 dimer interface [polypeptide binding]; other site 1229756005548 conserved gate region; other site 1229756005549 putative PBP binding loops; other site 1229756005550 ABC-ATPase subunit interface; other site 1229756005551 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1229756005552 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1229756005553 Walker A/P-loop; other site 1229756005554 ATP binding site [chemical binding]; other site 1229756005555 Q-loop/lid; other site 1229756005556 ABC transporter signature motif; other site 1229756005557 Walker B; other site 1229756005558 D-loop; other site 1229756005559 H-loop/switch region; other site 1229756005560 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1229756005561 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 1229756005562 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1229756005563 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1229756005564 gamma subunit interface [polypeptide binding]; other site 1229756005565 epsilon subunit interface [polypeptide binding]; other site 1229756005566 LBP interface [polypeptide binding]; other site 1229756005567 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1229756005568 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1229756005569 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1229756005570 alpha subunit interaction interface [polypeptide binding]; other site 1229756005571 Walker A motif; other site 1229756005572 ATP binding site [chemical binding]; other site 1229756005573 Walker B motif; other site 1229756005574 inhibitor binding site; inhibition site 1229756005575 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1229756005576 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1229756005577 core domain interface [polypeptide binding]; other site 1229756005578 delta subunit interface [polypeptide binding]; other site 1229756005579 epsilon subunit interface [polypeptide binding]; other site 1229756005580 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1229756005581 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1229756005582 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1229756005583 beta subunit interaction interface [polypeptide binding]; other site 1229756005584 Walker A motif; other site 1229756005585 ATP binding site [chemical binding]; other site 1229756005586 Walker B motif; other site 1229756005587 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1229756005588 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1229756005589 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1229756005590 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1229756005591 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1229756005592 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1229756005593 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1229756005594 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1229756005595 uracil transporter; Provisional; Region: PRK10720 1229756005596 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1229756005597 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1229756005598 G1 box; other site 1229756005599 GTP/Mg2+ binding site [chemical binding]; other site 1229756005600 G2 box; other site 1229756005601 Switch I region; other site 1229756005602 G3 box; other site 1229756005603 Switch II region; other site 1229756005604 G4 box; other site 1229756005605 G5 box; other site 1229756005606 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1229756005607 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1229756005608 active site 1229756005609 zinc binding site [ion binding]; other site 1229756005610 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1229756005611 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1229756005612 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1229756005613 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1229756005614 EDD domain protein, DegV family; Region: DegV; TIGR00762 1229756005615 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1229756005616 CrcB-like protein; Region: CRCB; pfam02537 1229756005617 CrcB-like protein; Region: CRCB; pfam02537 1229756005618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1229756005619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756005620 non-specific DNA binding site [nucleotide binding]; other site 1229756005621 salt bridge; other site 1229756005622 sequence-specific DNA binding site [nucleotide binding]; other site 1229756005623 short chain dehydrogenase; Validated; Region: PRK06182 1229756005624 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1229756005625 NADP binding site [chemical binding]; other site 1229756005626 active site 1229756005627 steroid binding site; other site 1229756005628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756005629 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1229756005630 NAD(P) binding site [chemical binding]; other site 1229756005631 active site 1229756005632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1229756005633 non-specific DNA binding site [nucleotide binding]; other site 1229756005634 salt bridge; other site 1229756005635 sequence-specific DNA binding site [nucleotide binding]; other site 1229756005636 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1229756005637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1229756005638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1229756005639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1229756005640 dimerization interface [polypeptide binding]; other site 1229756005641 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1229756005642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756005643 NAD(P) binding site [chemical binding]; other site 1229756005644 active site 1229756005645 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1229756005646 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1229756005647 intersubunit interface [polypeptide binding]; other site 1229756005648 active site 1229756005649 Zn2+ binding site [ion binding]; other site 1229756005650 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1229756005651 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1229756005652 AP (apurinic/apyrimidinic) site pocket; other site 1229756005653 DNA interaction; other site 1229756005654 Metal-binding active site; metal-binding site 1229756005655 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1229756005656 active site 1229756005657 dimer interface [polypeptide binding]; other site 1229756005658 magnesium binding site [ion binding]; other site 1229756005659 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1229756005660 active site 1229756005661 P-loop; other site 1229756005662 phosphorylation site [posttranslational modification] 1229756005663 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1229756005664 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1229756005665 active site 1229756005666 phosphorylation site [posttranslational modification] 1229756005667 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1229756005668 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1229756005669 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1229756005670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756005671 active site 1229756005672 motif I; other site 1229756005673 motif II; other site 1229756005674 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1229756005675 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1229756005676 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1229756005677 metal binding site 2 [ion binding]; metal-binding site 1229756005678 putative DNA binding helix; other site 1229756005679 metal binding site 1 [ion binding]; metal-binding site 1229756005680 dimer interface [polypeptide binding]; other site 1229756005681 structural Zn2+ binding site [ion binding]; other site 1229756005682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1229756005683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1229756005684 DNA binding site [nucleotide binding] 1229756005685 domain linker motif; other site 1229756005686 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1229756005687 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1229756005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005689 putative substrate translocation pore; other site 1229756005690 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1229756005691 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1229756005692 Ca binding site [ion binding]; other site 1229756005693 active site 1229756005694 catalytic site [active] 1229756005695 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1229756005696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1229756005697 dimerization interface [polypeptide binding]; other site 1229756005698 putative DNA binding site [nucleotide binding]; other site 1229756005699 putative Zn2+ binding site [ion binding]; other site 1229756005700 Cadmium resistance transporter; Region: Cad; pfam03596 1229756005701 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1229756005702 zinc binding site [ion binding]; other site 1229756005703 putative ligand binding site [chemical binding]; other site 1229756005704 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1229756005705 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1229756005706 TM-ABC transporter signature motif; other site 1229756005707 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1229756005708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756005709 Walker A/P-loop; other site 1229756005710 ATP binding site [chemical binding]; other site 1229756005711 Q-loop/lid; other site 1229756005712 ABC transporter signature motif; other site 1229756005713 Walker B; other site 1229756005714 D-loop; other site 1229756005715 H-loop/switch region; other site 1229756005716 K+ potassium transporter; Region: K_trans; pfam02705 1229756005717 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1229756005718 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1229756005719 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1229756005720 NAD binding site [chemical binding]; other site 1229756005721 dimer interface [polypeptide binding]; other site 1229756005722 substrate binding site [chemical binding]; other site 1229756005723 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1229756005724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1229756005725 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1229756005726 Walker A/P-loop; other site 1229756005727 ATP binding site [chemical binding]; other site 1229756005728 Q-loop/lid; other site 1229756005729 ABC transporter signature motif; other site 1229756005730 Walker B; other site 1229756005731 D-loop; other site 1229756005732 H-loop/switch region; other site 1229756005733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1229756005734 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1229756005735 TM-ABC transporter signature motif; other site 1229756005736 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1229756005737 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1229756005738 TM-ABC transporter signature motif; other site 1229756005739 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1229756005740 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1229756005741 Walker A/P-loop; other site 1229756005742 ATP binding site [chemical binding]; other site 1229756005743 Q-loop/lid; other site 1229756005744 ABC transporter signature motif; other site 1229756005745 Walker B; other site 1229756005746 D-loop; other site 1229756005747 H-loop/switch region; other site 1229756005748 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1229756005749 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1229756005750 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1229756005751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756005752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756005753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756005755 putative substrate translocation pore; other site 1229756005756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005757 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1229756005758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1229756005759 NAD(P) binding site [chemical binding]; other site 1229756005760 active site 1229756005761 Predicted transcriptional regulator [Transcription]; Region: COG1959 1229756005762 Transcriptional regulator; Region: Rrf2; pfam02082 1229756005763 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1229756005764 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1229756005765 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1229756005766 TrkA-N domain; Region: TrkA_N; pfam02254 1229756005767 TrkA-C domain; Region: TrkA_C; pfam02080 1229756005768 D-lactate dehydrogenase; Provisional; Region: PRK11183 1229756005769 FAD binding domain; Region: FAD_binding_4; pfam01565 1229756005770 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1229756005771 OsmC-like protein; Region: OsmC; cl00767 1229756005772 Predicted transcriptional regulators [Transcription]; Region: COG1695 1229756005773 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1229756005774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756005776 putative substrate translocation pore; other site 1229756005777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005778 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1229756005779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1229756005780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1229756005781 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1229756005782 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1229756005783 active site 1229756005784 methionine cluster; other site 1229756005785 phosphorylation site [posttranslational modification] 1229756005786 metal binding site [ion binding]; metal-binding site 1229756005787 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1229756005788 active site 1229756005789 P-loop; other site 1229756005790 phosphorylation site [posttranslational modification] 1229756005791 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1229756005792 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1229756005793 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1229756005794 beta-galactosidase; Region: BGL; TIGR03356 1229756005795 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1229756005796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1229756005797 DNA-binding site [nucleotide binding]; DNA binding site 1229756005798 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1229756005799 Predicted transcriptional regulator [Transcription]; Region: COG2378 1229756005800 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1229756005801 substrate binding site [chemical binding]; other site 1229756005802 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1229756005803 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1229756005804 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1229756005805 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1229756005806 heterotetramer interface [polypeptide binding]; other site 1229756005807 active site pocket [active] 1229756005808 cleavage site 1229756005809 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1229756005810 nucleotide binding site [chemical binding]; other site 1229756005811 N-acetyl-L-glutamate binding site [chemical binding]; other site 1229756005812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1229756005813 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1229756005814 inhibitor-cofactor binding pocket; inhibition site 1229756005815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756005816 catalytic residue [active] 1229756005817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1229756005818 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1229756005819 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1229756005820 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1229756005821 alpha-glucosidase; Provisional; Region: PRK10426 1229756005822 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1229756005823 putative active site [active] 1229756005824 putative catalytic site [active] 1229756005825 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1229756005826 Helix-turn-helix domain; Region: HTH_18; pfam12833 1229756005827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1229756005828 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1229756005829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1229756005830 S-adenosylmethionine binding site [chemical binding]; other site 1229756005831 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1229756005832 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1229756005833 acyl-activating enzyme (AAE) consensus motif; other site 1229756005834 putative AMP binding site [chemical binding]; other site 1229756005835 putative active site [active] 1229756005836 putative CoA binding site [chemical binding]; other site 1229756005837 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1229756005838 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1229756005839 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1229756005840 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1229756005841 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1229756005842 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1229756005843 amphipathic channel; other site 1229756005844 Asn-Pro-Ala signature motifs; other site 1229756005845 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1229756005846 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1229756005847 active site 1229756005848 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1229756005849 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1229756005850 DNA binding residues [nucleotide binding] 1229756005851 putative dimer interface [polypeptide binding]; other site 1229756005852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1229756005853 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1229756005854 putative ADP-binding pocket [chemical binding]; other site 1229756005855 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1229756005856 Sulfatase; Region: Sulfatase; pfam00884 1229756005857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1229756005858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756005859 Coenzyme A binding pocket [chemical binding]; other site 1229756005860 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1229756005861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756005862 active site 1229756005863 motif I; other site 1229756005864 motif II; other site 1229756005865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1229756005866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1229756005867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1229756005868 putative substrate translocation pore; other site 1229756005869 potential protein location (hypothetical protein C269_08955 [Leuconostoc gelidum JB7]) that overlaps RNA (tRNA-S) 1229756005870 transaminase; Reviewed; Region: PRK08068 1229756005871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1229756005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1229756005873 homodimer interface [polypeptide binding]; other site 1229756005874 catalytic residue [active] 1229756005875 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1229756005876 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1229756005877 putative active site [active] 1229756005878 catalytic triad [active] 1229756005879 putative dimer interface [polypeptide binding]; other site 1229756005880 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1229756005881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1229756005882 substrate binding site [chemical binding]; other site 1229756005883 oxyanion hole (OAH) forming residues; other site 1229756005884 trimer interface [polypeptide binding]; other site 1229756005885 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1229756005886 CoenzymeA binding site [chemical binding]; other site 1229756005887 subunit interaction site [polypeptide binding]; other site 1229756005888 PHB binding site; other site 1229756005889 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1229756005890 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1229756005891 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1229756005892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756005893 Coenzyme A binding pocket [chemical binding]; other site 1229756005894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1229756005895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1229756005896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1229756005897 active site 1229756005898 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1229756005899 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1229756005900 Cl binding site [ion binding]; other site 1229756005901 oligomer interface [polypeptide binding]; other site 1229756005902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1229756005903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1229756005904 Coenzyme A binding pocket [chemical binding]; other site 1229756005905 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1229756005906 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1229756005907 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1229756005908 active site 1229756005909 catalytic site [active] 1229756005910 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1229756005911 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1229756005912 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1229756005913 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1229756005914 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1229756005915 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1229756005916 Walker A/P-loop; other site 1229756005917 ATP binding site [chemical binding]; other site 1229756005918 Q-loop/lid; other site 1229756005919 ABC transporter signature motif; other site 1229756005920 Walker B; other site 1229756005921 D-loop; other site 1229756005922 H-loop/switch region; other site 1229756005923 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 1229756005924 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1229756005925 hypothetical protein; Provisional; Region: PRK12378 1229756005926 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1229756005927 pseudouridine synthase; Region: TIGR00093 1229756005928 probable active site [active]