-- dump date 20140619_131943 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1107880000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1107880000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1107880000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000004 Walker A motif; other site 1107880000005 ATP binding site [chemical binding]; other site 1107880000006 Walker B motif; other site 1107880000007 arginine finger; other site 1107880000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1107880000009 DnaA box-binding interface [nucleotide binding]; other site 1107880000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1107880000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1107880000012 putative DNA binding surface [nucleotide binding]; other site 1107880000013 dimer interface [polypeptide binding]; other site 1107880000014 beta-clamp/clamp loader binding surface; other site 1107880000015 beta-clamp/translesion DNA polymerase binding surface; other site 1107880000016 S4 domain; Region: S4_2; pfam13275 1107880000017 recombination protein F; Reviewed; Region: recF; PRK00064 1107880000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1107880000019 Walker A/P-loop; other site 1107880000020 ATP binding site [chemical binding]; other site 1107880000021 Q-loop/lid; other site 1107880000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000023 ABC transporter signature motif; other site 1107880000024 Walker B; other site 1107880000025 D-loop; other site 1107880000026 H-loop/switch region; other site 1107880000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1107880000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880000029 Mg2+ binding site [ion binding]; other site 1107880000030 G-X-G motif; other site 1107880000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1107880000032 anchoring element; other site 1107880000033 dimer interface [polypeptide binding]; other site 1107880000034 ATP binding site [chemical binding]; other site 1107880000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1107880000036 active site 1107880000037 putative metal-binding site [ion binding]; other site 1107880000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1107880000039 DNA gyrase subunit A; Validated; Region: PRK05560 1107880000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1107880000041 CAP-like domain; other site 1107880000042 active site 1107880000043 primary dimer interface [polypeptide binding]; other site 1107880000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880000050 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1107880000051 catalytic residues [active] 1107880000052 dimer interface [polypeptide binding]; other site 1107880000053 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1107880000054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880000055 active site 1107880000056 phosphorylation site [posttranslational modification] 1107880000057 intermolecular recognition site; other site 1107880000058 dimerization interface [polypeptide binding]; other site 1107880000059 LytTr DNA-binding domain; Region: LytTR; smart00850 1107880000060 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1107880000061 ATP binding site [chemical binding]; other site 1107880000062 Mg2+ binding site [ion binding]; other site 1107880000063 G-X-G motif; other site 1107880000064 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1107880000065 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1107880000066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880000067 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1107880000068 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1107880000069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880000070 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1107880000071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1107880000072 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1107880000073 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1107880000074 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1107880000075 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1107880000076 CoenzymeA binding site [chemical binding]; other site 1107880000077 subunit interaction site [polypeptide binding]; other site 1107880000078 PHB binding site; other site 1107880000079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1107880000080 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1107880000081 substrate binding site [chemical binding]; other site 1107880000082 oxyanion hole (OAH) forming residues; other site 1107880000083 trimer interface [polypeptide binding]; other site 1107880000084 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1107880000085 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1107880000086 putative active site [active] 1107880000087 catalytic triad [active] 1107880000088 putative dimer interface [polypeptide binding]; other site 1107880000089 transaminase; Reviewed; Region: PRK08068 1107880000090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880000091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880000092 homodimer interface [polypeptide binding]; other site 1107880000093 catalytic residue [active] 1107880000094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880000095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880000096 putative substrate translocation pore; other site 1107880000097 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1107880000098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880000099 active site 1107880000100 motif I; other site 1107880000101 motif II; other site 1107880000102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880000103 motif II; other site 1107880000104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880000105 Coenzyme A binding pocket [chemical binding]; other site 1107880000106 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1107880000107 Sulfatase; Region: Sulfatase; pfam00884 1107880000108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880000109 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1107880000110 putative ADP-binding pocket [chemical binding]; other site 1107880000111 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1107880000112 DNA binding residues [nucleotide binding] 1107880000113 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1107880000114 putative dimer interface [polypeptide binding]; other site 1107880000115 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1107880000116 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1107880000117 active site 1107880000118 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1107880000119 amphipathic channel; other site 1107880000120 Asn-Pro-Ala signature motifs; other site 1107880000121 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1107880000122 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1107880000123 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1107880000124 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1107880000125 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1107880000126 Predicted transcriptional regulators [Transcription]; Region: COG1725 1107880000127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880000128 DNA-binding site [nucleotide binding]; DNA binding site 1107880000129 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1107880000130 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1107880000131 Walker A/P-loop; other site 1107880000132 ATP binding site [chemical binding]; other site 1107880000133 Q-loop/lid; other site 1107880000134 ABC transporter signature motif; other site 1107880000135 Walker B; other site 1107880000136 D-loop; other site 1107880000137 H-loop/switch region; other site 1107880000138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1107880000139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000140 Walker A/P-loop; other site 1107880000141 ATP binding site [chemical binding]; other site 1107880000142 Q-loop/lid; other site 1107880000143 ABC transporter signature motif; other site 1107880000144 Walker B; other site 1107880000145 D-loop; other site 1107880000146 H-loop/switch region; other site 1107880000147 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1107880000148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880000149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880000150 active site 1107880000151 catalytic tetrad [active] 1107880000152 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1107880000153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1107880000154 inhibitor-cofactor binding pocket; inhibition site 1107880000155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880000156 catalytic residue [active] 1107880000157 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1107880000158 nucleotide binding site [chemical binding]; other site 1107880000159 N-acetyl-L-glutamate binding site [chemical binding]; other site 1107880000160 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1107880000161 heterotetramer interface [polypeptide binding]; other site 1107880000162 active site pocket [active] 1107880000163 cleavage site 1107880000164 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1107880000165 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1107880000166 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1107880000167 substrate binding site [chemical binding]; other site 1107880000168 Predicted transcriptional regulator [Transcription]; Region: COG2378 1107880000169 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1107880000170 TrkA-N domain; Region: TrkA_N; pfam02254 1107880000171 TrkA-C domain; Region: TrkA_C; pfam02080 1107880000172 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1107880000173 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1107880000174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880000175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880000176 putative substrate translocation pore; other site 1107880000177 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880000178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880000179 non-specific DNA binding site [nucleotide binding]; other site 1107880000180 salt bridge; other site 1107880000181 sequence-specific DNA binding site [nucleotide binding]; other site 1107880000182 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1107880000183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880000184 non-specific DNA binding site [nucleotide binding]; other site 1107880000185 salt bridge; other site 1107880000186 sequence-specific DNA binding site [nucleotide binding]; other site 1107880000187 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1107880000188 CAAX protease self-immunity; Region: Abi; pfam02517 1107880000189 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1107880000190 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1107880000191 Walker A/P-loop; other site 1107880000192 ATP binding site [chemical binding]; other site 1107880000193 Q-loop/lid; other site 1107880000194 ABC transporter signature motif; other site 1107880000195 Walker B; other site 1107880000196 D-loop; other site 1107880000197 H-loop/switch region; other site 1107880000198 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1107880000199 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1107880000200 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1107880000201 TM-ABC transporter signature motif; other site 1107880000202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1107880000203 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1107880000204 TM-ABC transporter signature motif; other site 1107880000205 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1107880000206 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1107880000207 NAD(P) binding site [chemical binding]; other site 1107880000208 LDH/MDH dimer interface [polypeptide binding]; other site 1107880000209 substrate binding site [chemical binding]; other site 1107880000210 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1107880000211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000212 Walker A/P-loop; other site 1107880000213 ATP binding site [chemical binding]; other site 1107880000214 Q-loop/lid; other site 1107880000215 ABC transporter signature motif; other site 1107880000216 Walker B; other site 1107880000217 D-loop; other site 1107880000218 H-loop/switch region; other site 1107880000219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1107880000220 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1107880000221 TM-ABC transporter signature motif; other site 1107880000222 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1107880000223 zinc binding site [ion binding]; other site 1107880000224 putative ligand binding site [chemical binding]; other site 1107880000225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880000226 non-specific DNA binding site [nucleotide binding]; other site 1107880000227 salt bridge; other site 1107880000228 sequence-specific DNA binding site [nucleotide binding]; other site 1107880000229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880000230 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1107880000231 NAD(P) binding site [chemical binding]; other site 1107880000232 active site 1107880000233 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1107880000234 HlyD family secretion protein; Region: HlyD_3; pfam13437 1107880000235 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1107880000236 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1107880000237 putative active site [active] 1107880000238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880000239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000240 Walker A/P-loop; other site 1107880000241 ATP binding site [chemical binding]; other site 1107880000242 Q-loop/lid; other site 1107880000243 ABC transporter signature motif; other site 1107880000244 Walker B; other site 1107880000245 D-loop; other site 1107880000246 H-loop/switch region; other site 1107880000247 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 1107880000248 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 1107880000249 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 1107880000250 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1107880000251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880000252 active site 1107880000253 phosphorylation site [posttranslational modification] 1107880000254 intermolecular recognition site; other site 1107880000255 dimerization interface [polypeptide binding]; other site 1107880000256 LytTr DNA-binding domain; Region: LytTR; pfam04397 1107880000257 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1107880000258 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1107880000259 dimer interface [polypeptide binding]; other site 1107880000260 substrate binding site [chemical binding]; other site 1107880000261 ATP binding site [chemical binding]; other site 1107880000262 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1107880000263 L-aspartate oxidase; Provisional; Region: PRK06175 1107880000264 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1107880000265 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880000266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880000267 non-specific DNA binding site [nucleotide binding]; other site 1107880000268 salt bridge; other site 1107880000269 sequence-specific DNA binding site [nucleotide binding]; other site 1107880000270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000271 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1107880000272 Walker A/P-loop; other site 1107880000273 ATP binding site [chemical binding]; other site 1107880000274 Q-loop/lid; other site 1107880000275 ABC transporter signature motif; other site 1107880000276 Walker B; other site 1107880000277 D-loop; other site 1107880000278 H-loop/switch region; other site 1107880000279 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1107880000280 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1107880000281 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1107880000282 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1107880000283 Ligand binding site; other site 1107880000284 Putative Catalytic site; other site 1107880000285 DXD motif; other site 1107880000286 GtrA-like protein; Region: GtrA; pfam04138 1107880000287 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1107880000288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880000289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880000290 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880000291 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1107880000292 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1107880000293 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1107880000294 putative dimer interface [polypeptide binding]; other site 1107880000295 N-terminal domain interface [polypeptide binding]; other site 1107880000296 putative substrate binding pocket (H-site) [chemical binding]; other site 1107880000297 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1107880000298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880000299 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1107880000300 Coenzyme A binding pocket [chemical binding]; other site 1107880000301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880000302 dimer interface [polypeptide binding]; other site 1107880000303 conserved gate region; other site 1107880000304 putative PBP binding loops; other site 1107880000305 ABC-ATPase subunit interface; other site 1107880000306 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880000307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880000308 Walker A/P-loop; other site 1107880000309 ATP binding site [chemical binding]; other site 1107880000310 Q-loop/lid; other site 1107880000311 ABC transporter signature motif; other site 1107880000312 Walker B; other site 1107880000313 D-loop; other site 1107880000314 H-loop/switch region; other site 1107880000315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880000316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880000317 substrate binding pocket [chemical binding]; other site 1107880000318 membrane-bound complex binding site; other site 1107880000319 hinge residues; other site 1107880000320 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1107880000321 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1107880000322 metal binding site [ion binding]; metal-binding site 1107880000323 dimer interface [polypeptide binding]; other site 1107880000324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880000325 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1107880000326 catalytic residues [active] 1107880000327 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1107880000328 amino acid transporter; Region: 2A0306; TIGR00909 1107880000329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880000330 acetoin reductases; Region: 23BDH; TIGR02415 1107880000331 NAD(P) binding site [chemical binding]; other site 1107880000332 active site 1107880000333 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1107880000334 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1107880000335 CrcB-like protein; Region: CRCB; pfam02537 1107880000336 CrcB-like protein; Region: CRCB; pfam02537 1107880000337 EDD domain protein, DegV family; Region: DegV; TIGR00762 1107880000338 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1107880000339 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1107880000340 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1107880000341 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1107880000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880000343 putative substrate translocation pore; other site 1107880000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880000345 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1107880000346 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1107880000347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1107880000348 xylose isomerase; Provisional; Region: PRK05474 1107880000349 xylose isomerase; Region: xylose_isom_A; TIGR02630 1107880000350 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1107880000351 N- and C-terminal domain interface [polypeptide binding]; other site 1107880000352 D-xylulose kinase; Region: XylB; TIGR01312 1107880000353 active site 1107880000354 MgATP binding site [chemical binding]; other site 1107880000355 catalytic site [active] 1107880000356 metal binding site [ion binding]; metal-binding site 1107880000357 xylulose binding site [chemical binding]; other site 1107880000358 homodimer interface [polypeptide binding]; other site 1107880000359 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1107880000360 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 1107880000361 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 1107880000362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880000363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880000364 substrate binding pocket [chemical binding]; other site 1107880000365 membrane-bound complex binding site; other site 1107880000366 hinge residues; other site 1107880000367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880000368 dimer interface [polypeptide binding]; other site 1107880000369 conserved gate region; other site 1107880000370 putative PBP binding loops; other site 1107880000371 ABC-ATPase subunit interface; other site 1107880000372 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1107880000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880000374 dimer interface [polypeptide binding]; other site 1107880000375 conserved gate region; other site 1107880000376 putative PBP binding loops; other site 1107880000377 ABC-ATPase subunit interface; other site 1107880000378 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880000379 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880000380 Walker A/P-loop; other site 1107880000381 ATP binding site [chemical binding]; other site 1107880000382 Q-loop/lid; other site 1107880000383 ABC transporter signature motif; other site 1107880000384 Walker B; other site 1107880000385 D-loop; other site 1107880000386 H-loop/switch region; other site 1107880000387 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1107880000388 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1107880000389 G1 box; other site 1107880000390 putative GEF interaction site [polypeptide binding]; other site 1107880000391 GTP/Mg2+ binding site [chemical binding]; other site 1107880000392 Switch I region; other site 1107880000393 G2 box; other site 1107880000394 G3 box; other site 1107880000395 Switch II region; other site 1107880000396 G4 box; other site 1107880000397 G5 box; other site 1107880000398 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1107880000399 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1107880000400 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1107880000401 dimer interface [polypeptide binding]; other site 1107880000402 substrate binding site [chemical binding]; other site 1107880000403 ATP binding site [chemical binding]; other site 1107880000404 acetoin reductase; Validated; Region: PRK08643 1107880000405 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1107880000406 NAD binding site [chemical binding]; other site 1107880000407 homotetramer interface [polypeptide binding]; other site 1107880000408 homodimer interface [polypeptide binding]; other site 1107880000409 active site 1107880000410 substrate binding site [chemical binding]; other site 1107880000411 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1107880000412 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1107880000413 putative catalytic cysteine [active] 1107880000414 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1107880000415 putative active site [active] 1107880000416 metal binding site [ion binding]; metal-binding site 1107880000417 TRAM domain; Region: TRAM; pfam01938 1107880000418 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1107880000419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880000420 S-adenosylmethionine binding site [chemical binding]; other site 1107880000421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000422 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1107880000423 Walker A motif; other site 1107880000424 ATP binding site [chemical binding]; other site 1107880000425 Walker B motif; other site 1107880000426 arginine finger; other site 1107880000427 UvrB/uvrC motif; Region: UVR; pfam02151 1107880000428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000429 Walker A motif; other site 1107880000430 ATP binding site [chemical binding]; other site 1107880000431 Walker B motif; other site 1107880000432 arginine finger; other site 1107880000433 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1107880000434 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1107880000435 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1107880000436 nudix motif; other site 1107880000437 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 1107880000438 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1107880000439 Aspartase; Region: Aspartase; cd01357 1107880000440 active sites [active] 1107880000441 tetramer interface [polypeptide binding]; other site 1107880000442 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1107880000443 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1107880000444 active site 1107880000445 dimer interface [polypeptide binding]; other site 1107880000446 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1107880000447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880000448 Coenzyme A binding pocket [chemical binding]; other site 1107880000449 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1107880000450 trimer interface [polypeptide binding]; other site 1107880000451 active site 1107880000452 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1107880000453 DNA repair protein RadA; Provisional; Region: PRK11823 1107880000454 Walker A motif/ATP binding site; other site 1107880000455 ATP binding site [chemical binding]; other site 1107880000456 Walker B motif; other site 1107880000457 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1107880000458 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1107880000459 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1107880000460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1107880000461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880000462 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1107880000463 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1107880000464 active site 1107880000465 HIGH motif; other site 1107880000466 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1107880000467 active site 1107880000468 KMSKS motif; other site 1107880000469 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1107880000470 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1107880000471 active site 1107880000472 HIGH motif; other site 1107880000473 Predicted archaeal kinase [General function prediction only]; Region: COG1608 1107880000474 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1107880000475 KMSKS motif; other site 1107880000476 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1107880000477 tRNA binding surface [nucleotide binding]; other site 1107880000478 anticodon binding site; other site 1107880000479 seryl-tRNA synthetase; Provisional; Region: PRK05431 1107880000480 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1107880000481 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1107880000482 dimer interface [polypeptide binding]; other site 1107880000483 active site 1107880000484 motif 1; other site 1107880000485 motif 2; other site 1107880000486 motif 3; other site 1107880000487 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1107880000488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1107880000489 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1107880000490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1107880000491 nucleotide binding region [chemical binding]; other site 1107880000492 ATP-binding site [chemical binding]; other site 1107880000493 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1107880000494 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1107880000495 RF-1 domain; Region: RF-1; pfam00472 1107880000496 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1107880000497 Clp amino terminal domain; Region: Clp_N; pfam02861 1107880000498 Clp amino terminal domain; Region: Clp_N; pfam02861 1107880000499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000500 Walker A motif; other site 1107880000501 ATP binding site [chemical binding]; other site 1107880000502 Walker B motif; other site 1107880000503 arginine finger; other site 1107880000504 UvrB/uvrC motif; Region: UVR; pfam02151 1107880000505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000506 Walker A motif; other site 1107880000507 ATP binding site [chemical binding]; other site 1107880000508 Walker B motif; other site 1107880000509 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1107880000510 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1107880000511 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1107880000512 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1107880000513 16S rRNA interaction site [nucleotide binding]; other site 1107880000514 streptomycin interaction site [chemical binding]; other site 1107880000515 23S rRNA interaction site [nucleotide binding]; other site 1107880000516 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1107880000517 30S ribosomal protein S7; Validated; Region: PRK05302 1107880000518 elongation factor G; Reviewed; Region: PRK12739 1107880000519 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1107880000520 G1 box; other site 1107880000521 putative GEF interaction site [polypeptide binding]; other site 1107880000522 GTP/Mg2+ binding site [chemical binding]; other site 1107880000523 Switch I region; other site 1107880000524 G2 box; other site 1107880000525 G3 box; other site 1107880000526 Switch II region; other site 1107880000527 G4 box; other site 1107880000528 G5 box; other site 1107880000529 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1107880000530 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1107880000531 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1107880000532 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1107880000533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880000534 putative substrate translocation pore; other site 1107880000535 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1107880000536 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1107880000537 Walker A/P-loop; other site 1107880000538 ATP binding site [chemical binding]; other site 1107880000539 Q-loop/lid; other site 1107880000540 ABC transporter signature motif; other site 1107880000541 Walker B; other site 1107880000542 D-loop; other site 1107880000543 H-loop/switch region; other site 1107880000544 TOBE domain; Region: TOBE_2; pfam08402 1107880000545 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1107880000546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880000547 dimer interface [polypeptide binding]; other site 1107880000548 conserved gate region; other site 1107880000549 putative PBP binding loops; other site 1107880000550 ABC-ATPase subunit interface; other site 1107880000551 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1107880000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880000553 dimer interface [polypeptide binding]; other site 1107880000554 conserved gate region; other site 1107880000555 putative PBP binding loops; other site 1107880000556 ABC-ATPase subunit interface; other site 1107880000557 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1107880000558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1107880000559 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1107880000560 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1107880000561 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1107880000562 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1107880000563 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1107880000564 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1107880000565 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1107880000566 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1107880000567 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1107880000568 putative translocon binding site; other site 1107880000569 protein-rRNA interface [nucleotide binding]; other site 1107880000570 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1107880000571 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1107880000572 G-X-X-G motif; other site 1107880000573 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1107880000574 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1107880000575 23S rRNA interface [nucleotide binding]; other site 1107880000576 5S rRNA interface [nucleotide binding]; other site 1107880000577 putative antibiotic binding site [chemical binding]; other site 1107880000578 L25 interface [polypeptide binding]; other site 1107880000579 L27 interface [polypeptide binding]; other site 1107880000580 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1107880000581 putative translocon interaction site; other site 1107880000582 23S rRNA interface [nucleotide binding]; other site 1107880000583 signal recognition particle (SRP54) interaction site; other site 1107880000584 L23 interface [polypeptide binding]; other site 1107880000585 trigger factor interaction site; other site 1107880000586 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1107880000587 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1107880000588 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1107880000589 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1107880000590 RNA binding site [nucleotide binding]; other site 1107880000591 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1107880000592 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1107880000593 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1107880000594 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1107880000595 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1107880000596 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1107880000597 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1107880000598 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1107880000599 5S rRNA interface [nucleotide binding]; other site 1107880000600 L27 interface [polypeptide binding]; other site 1107880000601 23S rRNA interface [nucleotide binding]; other site 1107880000602 L5 interface [polypeptide binding]; other site 1107880000603 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1107880000604 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1107880000605 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1107880000606 50S ribosomal protein L30; Reviewed; Region: rpmD; PRK05611 1107880000607 23S rRNA binding site - archaea [nucleotide binding]; other site 1107880000608 23S rRNA binding site - prokaryotes [nucleotide binding]; other site 1107880000609 5S rRNA binding site - archaea; other site 1107880000610 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1107880000611 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1107880000612 SecY translocase; Region: SecY; pfam00344 1107880000613 adenylate kinase; Reviewed; Region: adk; PRK00279 1107880000614 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1107880000615 AMP-binding site [chemical binding]; other site 1107880000616 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1107880000617 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1107880000618 rRNA binding site [nucleotide binding]; other site 1107880000619 predicted 30S ribosome binding site; other site 1107880000620 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1107880000621 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1107880000622 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1107880000623 30S ribosomal protein S11; Validated; Region: PRK05309 1107880000624 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1107880000625 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1107880000626 alphaNTD - beta interaction site [polypeptide binding]; other site 1107880000627 alphaNTD homodimer interface [polypeptide binding]; other site 1107880000628 alphaNTD - beta' interaction site [polypeptide binding]; other site 1107880000629 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1107880000630 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1107880000631 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1107880000632 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1107880000633 substrate binding pocket [chemical binding]; other site 1107880000634 chain length determination region; other site 1107880000635 substrate-Mg2+ binding site; other site 1107880000636 catalytic residues [active] 1107880000637 aspartate-rich region 1; other site 1107880000638 active site lid residues [active] 1107880000639 aspartate-rich region 2; other site 1107880000640 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1107880000641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880000642 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1107880000643 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880000644 Walker A/P-loop; other site 1107880000645 ATP binding site [chemical binding]; other site 1107880000646 Q-loop/lid; other site 1107880000647 ABC transporter signature motif; other site 1107880000648 Walker B; other site 1107880000649 D-loop; other site 1107880000650 H-loop/switch region; other site 1107880000651 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1107880000652 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880000653 Walker A/P-loop; other site 1107880000654 ATP binding site [chemical binding]; other site 1107880000655 Q-loop/lid; other site 1107880000656 ABC transporter signature motif; other site 1107880000657 Walker B; other site 1107880000658 D-loop; other site 1107880000659 H-loop/switch region; other site 1107880000660 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1107880000661 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1107880000662 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1107880000663 dimerization interface 3.5A [polypeptide binding]; other site 1107880000664 active site 1107880000665 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1107880000666 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1107880000667 23S rRNA interface [nucleotide binding]; other site 1107880000668 L3 interface [polypeptide binding]; other site 1107880000669 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1107880000670 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1107880000671 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1107880000672 triosephosphate isomerase; Provisional; Region: PRK14565 1107880000673 substrate binding site [chemical binding]; other site 1107880000674 dimer interface [polypeptide binding]; other site 1107880000675 catalytic triad [active] 1107880000676 enolase; Provisional; Region: eno; PRK00077 1107880000677 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1107880000678 dimer interface [polypeptide binding]; other site 1107880000679 metal binding site [ion binding]; metal-binding site 1107880000680 substrate binding pocket [chemical binding]; other site 1107880000681 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1107880000682 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1107880000683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880000684 Zn2+ binding site [ion binding]; other site 1107880000685 Mg2+ binding site [ion binding]; other site 1107880000686 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1107880000687 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 1107880000688 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1107880000689 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1107880000690 putative domain interface [polypeptide binding]; other site 1107880000691 putative active site [active] 1107880000692 catalytic site [active] 1107880000693 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1107880000694 putative domain interface [polypeptide binding]; other site 1107880000695 putative active site [active] 1107880000696 catalytic site [active] 1107880000697 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1107880000698 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1107880000699 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1107880000700 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1107880000701 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1107880000702 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1107880000703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880000704 ATP binding site [chemical binding]; other site 1107880000705 putative Mg++ binding site [ion binding]; other site 1107880000706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880000707 nucleotide binding region [chemical binding]; other site 1107880000708 ATP-binding site [chemical binding]; other site 1107880000709 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1107880000710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880000711 active site 1107880000712 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1107880000713 30S subunit binding site; other site 1107880000714 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1107880000715 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1107880000716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880000717 catalytic core [active] 1107880000718 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1107880000719 Domain of unknown function DUF21; Region: DUF21; pfam01595 1107880000720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1107880000721 Transporter associated domain; Region: CorC_HlyC; smart01091 1107880000722 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1107880000723 catalytic residues [active] 1107880000724 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1107880000725 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1107880000726 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1107880000727 active site 1107880000728 dimer interface [polypeptide binding]; other site 1107880000729 catalytic residues [active] 1107880000730 effector binding site; other site 1107880000731 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1107880000732 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 1107880000733 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1107880000734 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1107880000735 dimer interface [polypeptide binding]; other site 1107880000736 putative radical transfer pathway; other site 1107880000737 diiron center [ion binding]; other site 1107880000738 tyrosyl radical; other site 1107880000739 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1107880000740 active site 1107880000741 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1107880000742 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1107880000743 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1107880000744 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1107880000745 VanZ like family; Region: VanZ; pfam04892 1107880000746 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1107880000747 rod shape-determining protein MreB; Provisional; Region: PRK13930 1107880000748 MreB and similar proteins; Region: MreB_like; cd10225 1107880000749 nucleotide binding site [chemical binding]; other site 1107880000750 Mg binding site [ion binding]; other site 1107880000751 putative protofilament interaction site [polypeptide binding]; other site 1107880000752 RodZ interaction site [polypeptide binding]; other site 1107880000753 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1107880000754 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1107880000755 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1107880000756 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1107880000757 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1107880000758 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1107880000759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1107880000760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880000761 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1107880000762 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1107880000763 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1107880000764 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1107880000765 putative homodimer interface [polypeptide binding]; other site 1107880000766 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1107880000767 heterodimer interface [polypeptide binding]; other site 1107880000768 homodimer interface [polypeptide binding]; other site 1107880000769 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1107880000770 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1107880000771 23S rRNA interface [nucleotide binding]; other site 1107880000772 L7/L12 interface [polypeptide binding]; other site 1107880000773 putative thiostrepton binding site; other site 1107880000774 L25 interface [polypeptide binding]; other site 1107880000775 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1107880000776 mRNA/rRNA interface [nucleotide binding]; other site 1107880000777 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1107880000778 23S rRNA interface [nucleotide binding]; other site 1107880000779 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1107880000780 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1107880000781 peripheral dimer interface [polypeptide binding]; other site 1107880000782 core dimer interface [polypeptide binding]; other site 1107880000783 L10 interface [polypeptide binding]; other site 1107880000784 L11 interface [polypeptide binding]; other site 1107880000785 putative EF-Tu interaction site [polypeptide binding]; other site 1107880000786 putative EF-G interaction site [polypeptide binding]; other site 1107880000787 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1107880000788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880000789 S-adenosylmethionine binding site [chemical binding]; other site 1107880000790 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1107880000791 nucleoside/Zn binding site; other site 1107880000792 dimer interface [polypeptide binding]; other site 1107880000793 catalytic motif [active] 1107880000794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880000795 Zn2+ binding site [ion binding]; other site 1107880000796 Mg2+ binding site [ion binding]; other site 1107880000797 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1107880000798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880000799 Walker A motif; other site 1107880000800 ATP binding site [chemical binding]; other site 1107880000801 Walker B motif; other site 1107880000802 arginine finger; other site 1107880000803 recombination protein RecR; Reviewed; Region: recR; PRK00076 1107880000804 RecR protein; Region: RecR; pfam02132 1107880000805 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1107880000806 putative active site [active] 1107880000807 putative metal-binding site [ion binding]; other site 1107880000808 tetramer interface [polypeptide binding]; other site 1107880000809 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1107880000810 thymidylate kinase; Validated; Region: tmk; PRK00698 1107880000811 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1107880000812 TMP-binding site; other site 1107880000813 ATP-binding site [chemical binding]; other site 1107880000814 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1107880000815 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1107880000816 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1107880000817 Predicted methyltransferases [General function prediction only]; Region: COG0313 1107880000818 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1107880000819 putative SAM binding site [chemical binding]; other site 1107880000820 putative homodimer interface [polypeptide binding]; other site 1107880000821 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1107880000822 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1107880000823 active site 1107880000824 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1107880000825 active site 2 [active] 1107880000826 active site 1 [active] 1107880000827 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1107880000828 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1107880000829 NAD binding site [chemical binding]; other site 1107880000830 homodimer interface [polypeptide binding]; other site 1107880000831 active site 1107880000832 substrate binding site [chemical binding]; other site 1107880000833 FeoA domain; Region: FeoA; pfam04023 1107880000834 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1107880000835 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1107880000836 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1107880000837 G1 box; other site 1107880000838 GTP/Mg2+ binding site [chemical binding]; other site 1107880000839 Switch I region; other site 1107880000840 G2 box; other site 1107880000841 G3 box; other site 1107880000842 Switch II region; other site 1107880000843 G4 box; other site 1107880000844 G5 box; other site 1107880000845 Nucleoside recognition; Region: Gate; pfam07670 1107880000846 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1107880000847 Nucleoside recognition; Region: Gate; pfam07670 1107880000848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880000849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880000850 DNA binding site [nucleotide binding] 1107880000851 domain linker motif; other site 1107880000852 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1107880000853 dimerization interface [polypeptide binding]; other site 1107880000854 ligand binding site [chemical binding]; other site 1107880000855 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1107880000856 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1107880000857 active site turn [active] 1107880000858 phosphorylation site [posttranslational modification] 1107880000859 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1107880000860 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1107880000861 HPr interaction site; other site 1107880000862 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1107880000863 active site 1107880000864 phosphorylation site [posttranslational modification] 1107880000865 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1107880000866 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1107880000867 substrate binding [chemical binding]; other site 1107880000868 active site 1107880000869 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1107880000870 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1107880000871 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1107880000872 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1107880000873 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1107880000874 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1107880000875 Substrate-binding site [chemical binding]; other site 1107880000876 Substrate specificity [chemical binding]; other site 1107880000877 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1107880000878 nucleotide binding site [chemical binding]; other site 1107880000879 homotetrameric interface [polypeptide binding]; other site 1107880000880 putative phosphate binding site [ion binding]; other site 1107880000881 putative allosteric binding site; other site 1107880000882 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1107880000883 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1107880000884 putative catalytic cysteine [active] 1107880000885 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1107880000886 active site 1107880000887 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1107880000888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880000889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880000890 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1107880000891 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1107880000892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880000893 Zn2+ binding site [ion binding]; other site 1107880000894 Mg2+ binding site [ion binding]; other site 1107880000895 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1107880000896 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1107880000897 active site 1107880000898 HIGH motif; other site 1107880000899 KMSKS motif; other site 1107880000900 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1107880000901 tRNA binding surface [nucleotide binding]; other site 1107880000902 anticodon binding site; other site 1107880000903 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1107880000904 dimer interface [polypeptide binding]; other site 1107880000905 putative tRNA-binding site [nucleotide binding]; other site 1107880000906 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1107880000907 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1107880000908 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1107880000909 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1107880000910 BioY family; Region: BioY; pfam02632 1107880000911 potential frameshift: common BLAST hit: gi|339491607|ref|YP_004706112.1| adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1107880000912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1107880000913 catalytic residue [active] 1107880000914 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1107880000915 AAA domain; Region: AAA_26; pfam13500 1107880000916 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1107880000917 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1107880000918 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1107880000919 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1107880000920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1107880000921 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1107880000922 active site 1107880000923 metal binding site [ion binding]; metal-binding site 1107880000924 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1107880000925 MarR family; Region: MarR_2; pfam12802 1107880000926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1107880000927 MarR family; Region: MarR_2; cl17246 1107880000928 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1107880000929 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1107880000930 dimer interface [polypeptide binding]; other site 1107880000931 active site 1107880000932 CoA binding pocket [chemical binding]; other site 1107880000933 acyl carrier protein; Provisional; Region: acpP; PRK00982 1107880000934 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1107880000935 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1107880000936 FMN binding site [chemical binding]; other site 1107880000937 substrate binding site [chemical binding]; other site 1107880000938 putative catalytic residue [active] 1107880000939 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1107880000940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1107880000941 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1107880000942 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1107880000943 NAD(P) binding site [chemical binding]; other site 1107880000944 homotetramer interface [polypeptide binding]; other site 1107880000945 homodimer interface [polypeptide binding]; other site 1107880000946 active site 1107880000947 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1107880000948 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1107880000949 dimer interface [polypeptide binding]; other site 1107880000950 active site 1107880000951 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1107880000952 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1107880000953 carboxyltransferase (CT) interaction site; other site 1107880000954 biotinylation site [posttranslational modification]; other site 1107880000955 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1107880000956 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1107880000957 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1107880000958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1107880000959 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1107880000960 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1107880000961 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1107880000962 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1107880000963 MepB protein; Region: MepB; cl01985 1107880000964 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1107880000965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1107880000966 active site 1107880000967 HIGH motif; other site 1107880000968 nucleotide binding site [chemical binding]; other site 1107880000969 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1107880000970 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1107880000971 active site 1107880000972 KMSKS motif; other site 1107880000973 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1107880000974 tRNA binding surface [nucleotide binding]; other site 1107880000975 anticodon binding site; other site 1107880000976 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1107880000977 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1107880000978 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1107880000979 dimer interface [polypeptide binding]; other site 1107880000980 active site 1107880000981 CoA binding pocket [chemical binding]; other site 1107880000982 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880000983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880000984 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1107880000985 NlpC/P60 family; Region: NLPC_P60; cl17555 1107880000986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880000987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880000988 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880000989 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1107880000990 FemAB family; Region: FemAB; pfam02388 1107880000991 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1107880000992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1107880000993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1107880000994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1107880000995 dimerization interface [polypeptide binding]; other site 1107880000996 putative DNA binding site [nucleotide binding]; other site 1107880000997 putative Zn2+ binding site [ion binding]; other site 1107880000998 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1107880000999 Predicted integral membrane protein [Function unknown]; Region: COG5658 1107880001000 SdpI/YhfL protein family; Region: SdpI; pfam13630 1107880001001 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880001002 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1107880001003 Walker A/P-loop; other site 1107880001004 ATP binding site [chemical binding]; other site 1107880001005 Q-loop/lid; other site 1107880001006 ABC transporter signature motif; other site 1107880001007 Walker B; other site 1107880001008 D-loop; other site 1107880001009 H-loop/switch region; other site 1107880001010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1107880001011 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1107880001012 FtsX-like permease family; Region: FtsX; pfam02687 1107880001013 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1107880001014 Protein of unknown function (DUF454); Region: DUF454; cl01063 1107880001015 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1107880001016 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1107880001017 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1107880001018 homodimer interface [polypeptide binding]; other site 1107880001019 catalytic residues [active] 1107880001020 NAD binding site [chemical binding]; other site 1107880001021 substrate binding pocket [chemical binding]; other site 1107880001022 flexible flap; other site 1107880001023 NAD-dependent deacetylase; Provisional; Region: PRK00481 1107880001024 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1107880001025 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1107880001026 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1107880001027 manganese transport protein MntH; Reviewed; Region: PRK00701 1107880001028 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1107880001029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1107880001030 Ligand Binding Site [chemical binding]; other site 1107880001031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1107880001032 dimerization interface [polypeptide binding]; other site 1107880001033 putative DNA binding site [nucleotide binding]; other site 1107880001034 putative Zn2+ binding site [ion binding]; other site 1107880001035 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1107880001036 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1107880001037 peptide binding site [polypeptide binding]; other site 1107880001038 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1107880001039 active site 1107880001040 tetramer interface [polypeptide binding]; other site 1107880001041 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1107880001042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880001043 S-adenosylmethionine binding site [chemical binding]; other site 1107880001044 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1107880001045 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880001046 P-loop; other site 1107880001047 Magnesium ion binding site [ion binding]; other site 1107880001048 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1107880001049 ParB-like nuclease domain; Region: ParB; smart00470 1107880001050 KorB domain; Region: KorB; pfam08535 1107880001051 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1107880001052 GTP-binding protein YchF; Reviewed; Region: PRK09601 1107880001053 YchF GTPase; Region: YchF; cd01900 1107880001054 G1 box; other site 1107880001055 GTP/Mg2+ binding site [chemical binding]; other site 1107880001056 Switch I region; other site 1107880001057 G2 box; other site 1107880001058 Switch II region; other site 1107880001059 G3 box; other site 1107880001060 G4 box; other site 1107880001061 G5 box; other site 1107880001062 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1107880001063 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1107880001064 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880001065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880001066 active site 1107880001067 phosphorylation site [posttranslational modification] 1107880001068 intermolecular recognition site; other site 1107880001069 dimerization interface [polypeptide binding]; other site 1107880001070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880001071 DNA binding site [nucleotide binding] 1107880001072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1107880001073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880001074 dimer interface [polypeptide binding]; other site 1107880001075 phosphorylation site [posttranslational modification] 1107880001076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880001077 ATP binding site [chemical binding]; other site 1107880001078 Mg2+ binding site [ion binding]; other site 1107880001079 G-X-G motif; other site 1107880001080 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1107880001081 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1107880001082 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1107880001083 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1107880001084 active site 1107880001085 trimer interface [polypeptide binding]; other site 1107880001086 allosteric site; other site 1107880001087 active site lid [active] 1107880001088 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1107880001089 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1107880001090 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1107880001091 active site 1107880001092 dimer interface [polypeptide binding]; other site 1107880001093 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1107880001094 dimer interface [polypeptide binding]; other site 1107880001095 active site 1107880001096 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1107880001097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880001098 DNA-binding site [nucleotide binding]; DNA binding site 1107880001099 TrkA-C domain; Region: TrkA_C; pfam02080 1107880001100 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1107880001101 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1107880001102 Walker A/P-loop; other site 1107880001103 ATP binding site [chemical binding]; other site 1107880001104 Q-loop/lid; other site 1107880001105 ABC transporter signature motif; other site 1107880001106 Walker B; other site 1107880001107 D-loop; other site 1107880001108 H-loop/switch region; other site 1107880001109 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1107880001110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001111 dimer interface [polypeptide binding]; other site 1107880001112 conserved gate region; other site 1107880001113 putative PBP binding loops; other site 1107880001114 ABC-ATPase subunit interface; other site 1107880001115 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1107880001116 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1107880001117 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1107880001118 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1107880001119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880001120 Walker A/P-loop; other site 1107880001121 ATP binding site [chemical binding]; other site 1107880001122 Q-loop/lid; other site 1107880001123 ABC transporter signature motif; other site 1107880001124 Walker B; other site 1107880001125 D-loop; other site 1107880001126 H-loop/switch region; other site 1107880001127 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1107880001128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880001129 non-specific DNA binding site [nucleotide binding]; other site 1107880001130 salt bridge; other site 1107880001131 sequence-specific DNA binding site [nucleotide binding]; other site 1107880001132 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1107880001133 Isochorismatase family; Region: Isochorismatase; pfam00857 1107880001134 catalytic triad [active] 1107880001135 conserved cis-peptide bond; other site 1107880001136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001137 dimer interface [polypeptide binding]; other site 1107880001138 conserved gate region; other site 1107880001139 putative PBP binding loops; other site 1107880001140 ABC-ATPase subunit interface; other site 1107880001141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880001142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880001143 substrate binding pocket [chemical binding]; other site 1107880001144 membrane-bound complex binding site; other site 1107880001145 hinge residues; other site 1107880001146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001147 dimer interface [polypeptide binding]; other site 1107880001148 conserved gate region; other site 1107880001149 putative PBP binding loops; other site 1107880001150 ABC-ATPase subunit interface; other site 1107880001151 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880001152 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880001153 Walker A/P-loop; other site 1107880001154 ATP binding site [chemical binding]; other site 1107880001155 Q-loop/lid; other site 1107880001156 ABC transporter signature motif; other site 1107880001157 Walker B; other site 1107880001158 D-loop; other site 1107880001159 H-loop/switch region; other site 1107880001160 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1107880001161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880001162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880001163 homodimer interface [polypeptide binding]; other site 1107880001164 catalytic residue [active] 1107880001165 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1107880001166 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1107880001167 NAD binding site [chemical binding]; other site 1107880001168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880001169 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880001170 Walker A/P-loop; other site 1107880001171 ATP binding site [chemical binding]; other site 1107880001172 Q-loop/lid; other site 1107880001173 ABC transporter signature motif; other site 1107880001174 Walker B; other site 1107880001175 D-loop; other site 1107880001176 H-loop/switch region; other site 1107880001177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880001178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880001179 putative substrate translocation pore; other site 1107880001180 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1107880001181 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1107880001182 Preprotein translocase subunit; Region: YajC; cl00806 1107880001183 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1107880001184 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1107880001185 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1107880001186 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1107880001187 HD domain; Region: HD_3; cl17350 1107880001188 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1107880001189 nudix motif; other site 1107880001190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880001191 catalytic core [active] 1107880001192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880001193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880001194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880001195 putative substrate translocation pore; other site 1107880001196 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1107880001197 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1107880001198 active site 1107880001199 homodimer interface [polypeptide binding]; other site 1107880001200 catalytic site [active] 1107880001201 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1107880001202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880001203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880001204 Walker A/P-loop; other site 1107880001205 ATP binding site [chemical binding]; other site 1107880001206 Q-loop/lid; other site 1107880001207 ABC transporter signature motif; other site 1107880001208 Walker B; other site 1107880001209 D-loop; other site 1107880001210 H-loop/switch region; other site 1107880001211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1107880001212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880001213 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1107880001214 Walker A/P-loop; other site 1107880001215 ATP binding site [chemical binding]; other site 1107880001216 Q-loop/lid; other site 1107880001217 ABC transporter signature motif; other site 1107880001218 Walker B; other site 1107880001219 D-loop; other site 1107880001220 H-loop/switch region; other site 1107880001221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880001222 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1107880001223 putative ADP-binding pocket [chemical binding]; other site 1107880001224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880001225 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1107880001226 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1107880001227 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1107880001228 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1107880001229 Sulfatase; Region: Sulfatase; pfam00884 1107880001230 excinuclease ABC subunit B; Provisional; Region: PRK05298 1107880001231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880001232 ATP binding site [chemical binding]; other site 1107880001233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880001234 nucleotide binding region [chemical binding]; other site 1107880001235 ATP-binding site [chemical binding]; other site 1107880001236 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1107880001237 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1107880001238 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1107880001239 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1107880001240 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1107880001241 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1107880001242 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1107880001243 phosphate binding site [ion binding]; other site 1107880001244 putative substrate binding pocket [chemical binding]; other site 1107880001245 dimer interface [polypeptide binding]; other site 1107880001246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1107880001247 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1107880001248 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1107880001249 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1107880001250 oligomer interface [polypeptide binding]; other site 1107880001251 active site residues [active] 1107880001252 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1107880001253 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1107880001254 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1107880001255 putative active site [active] 1107880001256 catalytic residue [active] 1107880001257 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1107880001258 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1107880001259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880001260 ATP binding site [chemical binding]; other site 1107880001261 putative Mg++ binding site [ion binding]; other site 1107880001262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880001263 nucleotide binding region [chemical binding]; other site 1107880001264 ATP-binding site [chemical binding]; other site 1107880001265 TRCF domain; Region: TRCF; pfam03461 1107880001266 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1107880001267 RNA binding surface [nucleotide binding]; other site 1107880001268 Septum formation initiator; Region: DivIC; pfam04977 1107880001269 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1107880001270 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1107880001271 Ligand Binding Site [chemical binding]; other site 1107880001272 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1107880001273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880001274 active site 1107880001275 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1107880001276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880001277 Walker A motif; other site 1107880001278 ATP binding site [chemical binding]; other site 1107880001279 Walker B motif; other site 1107880001280 arginine finger; other site 1107880001281 Peptidase family M41; Region: Peptidase_M41; pfam01434 1107880001282 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1107880001283 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1107880001284 dimerization interface [polypeptide binding]; other site 1107880001285 domain crossover interface; other site 1107880001286 redox-dependent activation switch; other site 1107880001287 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1107880001288 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1107880001289 dimer interface [polypeptide binding]; other site 1107880001290 putative anticodon binding site; other site 1107880001291 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1107880001292 motif 1; other site 1107880001293 active site 1107880001294 motif 2; other site 1107880001295 motif 3; other site 1107880001296 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1107880001297 pseudouridine synthase; Region: TIGR00093 1107880001298 probable active site [active] 1107880001299 hypothetical protein; Provisional; Region: PRK12378 1107880001300 Ferrochelatase; Region: Ferrochelatase; pfam00762 1107880001301 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1107880001302 C-terminal domain interface [polypeptide binding]; other site 1107880001303 active site 1107880001304 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1107880001305 active site 1107880001306 N-terminal domain interface [polypeptide binding]; other site 1107880001307 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1107880001308 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1107880001309 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1107880001310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1107880001311 Walker A/P-loop; other site 1107880001312 ATP binding site [chemical binding]; other site 1107880001313 Q-loop/lid; other site 1107880001314 ABC transporter signature motif; other site 1107880001315 Walker B; other site 1107880001316 D-loop; other site 1107880001317 H-loop/switch region; other site 1107880001318 LytTr DNA-binding domain; Region: LytTR; smart00850 1107880001319 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1107880001320 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1107880001321 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1107880001322 active site 1107880001323 putative interdomain interaction site [polypeptide binding]; other site 1107880001324 putative metal-binding site [ion binding]; other site 1107880001325 putative nucleotide binding site [chemical binding]; other site 1107880001326 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1107880001327 domain I; other site 1107880001328 DNA binding groove [nucleotide binding] 1107880001329 phosphate binding site [ion binding]; other site 1107880001330 domain II; other site 1107880001331 domain III; other site 1107880001332 nucleotide binding site [chemical binding]; other site 1107880001333 catalytic site [active] 1107880001334 domain IV; other site 1107880001335 potential frameshift: common BLAST hit: gi|116617540|ref|YP_817911.1| major facilitator superfamily permease 1107880001336 alanine racemase; Reviewed; Region: alr; PRK00053 1107880001337 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1107880001338 active site 1107880001339 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1107880001340 dimer interface [polypeptide binding]; other site 1107880001341 substrate binding site [chemical binding]; other site 1107880001342 catalytic residues [active] 1107880001343 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1107880001344 tetramer interfaces [polypeptide binding]; other site 1107880001345 binuclear metal-binding site [ion binding]; other site 1107880001346 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1107880001347 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1107880001348 active site 1107880001349 dimer interface [polypeptide binding]; other site 1107880001350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1107880001351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880001352 DNA-binding site [nucleotide binding]; DNA binding site 1107880001353 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1107880001354 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1107880001355 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1107880001356 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1107880001357 Walker A/P-loop; other site 1107880001358 ATP binding site [chemical binding]; other site 1107880001359 Q-loop/lid; other site 1107880001360 ABC transporter signature motif; other site 1107880001361 Walker B; other site 1107880001362 D-loop; other site 1107880001363 H-loop/switch region; other site 1107880001364 NIL domain; Region: NIL; pfam09383 1107880001365 hypothetical protein; Provisional; Region: PRK06446 1107880001366 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1107880001367 metal binding site [ion binding]; metal-binding site 1107880001368 dimer interface [polypeptide binding]; other site 1107880001369 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1107880001370 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1107880001371 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1107880001372 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1107880001373 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1107880001374 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1107880001375 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1107880001376 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1107880001377 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1107880001378 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1107880001379 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1107880001380 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1107880001381 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 1107880001382 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1107880001383 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1107880001384 ligand binding site [chemical binding]; other site 1107880001385 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880001386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880001387 substrate binding pocket [chemical binding]; other site 1107880001388 membrane-bound complex binding site; other site 1107880001389 hinge residues; other site 1107880001390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001391 dimer interface [polypeptide binding]; other site 1107880001392 conserved gate region; other site 1107880001393 putative PBP binding loops; other site 1107880001394 ABC-ATPase subunit interface; other site 1107880001395 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880001396 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880001397 Walker A/P-loop; other site 1107880001398 ATP binding site [chemical binding]; other site 1107880001399 Q-loop/lid; other site 1107880001400 ABC transporter signature motif; other site 1107880001401 Walker B; other site 1107880001402 D-loop; other site 1107880001403 H-loop/switch region; other site 1107880001404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880001405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880001406 substrate binding pocket [chemical binding]; other site 1107880001407 membrane-bound complex binding site; other site 1107880001408 hinge residues; other site 1107880001409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001410 dimer interface [polypeptide binding]; other site 1107880001411 conserved gate region; other site 1107880001412 putative PBP binding loops; other site 1107880001413 ABC-ATPase subunit interface; other site 1107880001414 Competence protein CoiA-like family; Region: CoiA; cl11541 1107880001415 oligoendopeptidase F; Region: pepF; TIGR00181 1107880001416 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1107880001417 active site 1107880001418 Zn binding site [ion binding]; other site 1107880001419 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1107880001420 active site 1107880001421 catalytic motif [active] 1107880001422 Zn binding site [ion binding]; other site 1107880001423 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1107880001424 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1107880001425 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1107880001426 putative ligand binding site [chemical binding]; other site 1107880001427 putative NAD binding site [chemical binding]; other site 1107880001428 catalytic site [active] 1107880001429 Predicted transcriptional regulators [Transcription]; Region: COG1733 1107880001430 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1107880001431 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1107880001432 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1107880001433 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1107880001434 dimer interface [polypeptide binding]; other site 1107880001435 motif 1; other site 1107880001436 active site 1107880001437 motif 2; other site 1107880001438 motif 3; other site 1107880001439 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1107880001440 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1107880001441 putative tRNA-binding site [nucleotide binding]; other site 1107880001442 B3/4 domain; Region: B3_4; pfam03483 1107880001443 tRNA synthetase B5 domain; Region: B5; smart00874 1107880001444 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1107880001445 dimer interface [polypeptide binding]; other site 1107880001446 motif 1; other site 1107880001447 motif 3; other site 1107880001448 motif 2; other site 1107880001449 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1107880001450 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1107880001451 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1107880001452 hinge; other site 1107880001453 active site 1107880001454 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1107880001455 TRAM domain; Region: TRAM; cl01282 1107880001456 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1107880001457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880001458 S-adenosylmethionine binding site [chemical binding]; other site 1107880001459 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1107880001460 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1107880001461 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880001462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1107880001463 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1107880001464 Beta-lactamase; Region: Beta-lactamase; pfam00144 1107880001465 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1107880001466 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1107880001467 ATP binding site [chemical binding]; other site 1107880001468 Mg++ binding site [ion binding]; other site 1107880001469 motif III; other site 1107880001470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880001471 nucleotide binding region [chemical binding]; other site 1107880001472 ATP-binding site [chemical binding]; other site 1107880001473 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1107880001474 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880001475 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1107880001476 putative transporter; Provisional; Region: PRK10504 1107880001477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880001478 putative substrate translocation pore; other site 1107880001479 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1107880001480 MPN+ (JAMM) motif; other site 1107880001481 Zinc-binding site [ion binding]; other site 1107880001482 thymidylate synthase; Region: thym_sym; TIGR03284 1107880001483 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1107880001484 dimerization interface [polypeptide binding]; other site 1107880001485 active site 1107880001486 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1107880001487 catalytic motif [active] 1107880001488 Zn binding site [ion binding]; other site 1107880001489 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1107880001490 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1107880001491 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1107880001492 homodimer interface [polypeptide binding]; other site 1107880001493 NADP binding site [chemical binding]; other site 1107880001494 substrate binding site [chemical binding]; other site 1107880001495 Type II/IV secretion system protein; Region: T2SE; pfam00437 1107880001496 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1107880001497 Walker A motif; other site 1107880001498 ATP binding site [chemical binding]; other site 1107880001499 Walker B motif; other site 1107880001500 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1107880001501 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1107880001502 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1107880001503 hypothetical protein; Provisional; Region: PRK10506 1107880001504 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1107880001505 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1107880001506 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1107880001507 propionate/acetate kinase; Provisional; Region: PRK12379 1107880001508 Ubiquitin-like proteins; Region: UBQ; cl00155 1107880001509 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1107880001510 dimerization interface [polypeptide binding]; other site 1107880001511 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1107880001512 Sugar transport protein; Region: Sugar_transport; pfam06800 1107880001513 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1107880001514 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1107880001515 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1107880001516 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1107880001517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880001518 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1107880001519 NAD(P) binding site [chemical binding]; other site 1107880001520 active site 1107880001521 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1107880001522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880001523 Walker A motif; other site 1107880001524 ATP binding site [chemical binding]; other site 1107880001525 Walker B motif; other site 1107880001526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 1107880001527 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1107880001528 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1107880001529 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1107880001530 putative ligand binding site [chemical binding]; other site 1107880001531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1107880001532 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1107880001533 TM-ABC transporter signature motif; other site 1107880001534 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1107880001535 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1107880001536 TM-ABC transporter signature motif; other site 1107880001537 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1107880001538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1107880001539 Walker A/P-loop; other site 1107880001540 ATP binding site [chemical binding]; other site 1107880001541 Q-loop/lid; other site 1107880001542 ABC transporter signature motif; other site 1107880001543 Walker B; other site 1107880001544 D-loop; other site 1107880001545 H-loop/switch region; other site 1107880001546 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1107880001547 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1107880001548 Walker A/P-loop; other site 1107880001549 ATP binding site [chemical binding]; other site 1107880001550 Q-loop/lid; other site 1107880001551 ABC transporter signature motif; other site 1107880001552 Walker B; other site 1107880001553 D-loop; other site 1107880001554 H-loop/switch region; other site 1107880001555 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1107880001556 substrate binding site [chemical binding]; other site 1107880001557 multimerization interface [polypeptide binding]; other site 1107880001558 ATP binding site [chemical binding]; other site 1107880001559 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1107880001560 dimer interface [polypeptide binding]; other site 1107880001561 substrate binding site [chemical binding]; other site 1107880001562 ATP binding site [chemical binding]; other site 1107880001563 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1107880001564 thiamine phosphate binding site [chemical binding]; other site 1107880001565 active site 1107880001566 pyrophosphate binding site [ion binding]; other site 1107880001567 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1107880001568 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1107880001569 NAD(P) binding site [chemical binding]; other site 1107880001570 catalytic residues [active] 1107880001571 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1107880001572 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1107880001573 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1107880001574 active site 1107880001575 Zn binding site [ion binding]; other site 1107880001576 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1107880001577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1107880001578 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1107880001579 metal binding site 2 [ion binding]; metal-binding site 1107880001580 putative DNA binding helix; other site 1107880001581 metal binding site 1 [ion binding]; metal-binding site 1107880001582 dimer interface [polypeptide binding]; other site 1107880001583 structural Zn2+ binding site [ion binding]; other site 1107880001584 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1107880001585 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1107880001586 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1107880001587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1107880001588 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1107880001589 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1107880001590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880001591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880001592 DNA binding site [nucleotide binding] 1107880001593 domain linker motif; other site 1107880001594 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1107880001595 putative dimerization interface [polypeptide binding]; other site 1107880001596 putative ligand binding site [chemical binding]; other site 1107880001597 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1107880001598 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1107880001599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1107880001600 substrate binding site [chemical binding]; other site 1107880001601 ATP binding site [chemical binding]; other site 1107880001602 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1107880001603 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1107880001604 putative ligand binding site [chemical binding]; other site 1107880001605 putative NAD binding site [chemical binding]; other site 1107880001606 catalytic site [active] 1107880001607 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1107880001608 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1107880001609 Zn binding site [ion binding]; other site 1107880001610 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1107880001611 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1107880001612 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 1107880001613 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1107880001614 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1107880001615 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1107880001616 HPr interaction site; other site 1107880001617 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1107880001618 active site 1107880001619 phosphorylation site [posttranslational modification] 1107880001620 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1107880001621 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1107880001622 active site turn [active] 1107880001623 phosphorylation site [posttranslational modification] 1107880001624 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1107880001625 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1107880001626 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1107880001627 Ca binding site [ion binding]; other site 1107880001628 active site 1107880001629 catalytic site [active] 1107880001630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880001631 DNA-binding site [nucleotide binding]; DNA binding site 1107880001632 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1107880001633 UTRA domain; Region: UTRA; pfam07702 1107880001634 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1107880001635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880001636 Zn2+ binding site [ion binding]; other site 1107880001637 Mg2+ binding site [ion binding]; other site 1107880001638 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1107880001639 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1107880001640 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1107880001641 BioY family; Region: BioY; pfam02632 1107880001642 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1107880001643 CHY zinc finger; Region: zf-CHY; pfam05495 1107880001644 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1107880001645 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1107880001646 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1107880001647 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1107880001648 CTP synthetase; Validated; Region: pyrG; PRK05380 1107880001649 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1107880001650 Catalytic site [active] 1107880001651 active site 1107880001652 UTP binding site [chemical binding]; other site 1107880001653 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1107880001654 active site 1107880001655 putative oxyanion hole; other site 1107880001656 catalytic triad [active] 1107880001657 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1107880001658 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1107880001659 GIY-YIG motif/motif A; other site 1107880001660 active site 1107880001661 catalytic site [active] 1107880001662 putative DNA binding site [nucleotide binding]; other site 1107880001663 metal binding site [ion binding]; metal-binding site 1107880001664 UvrB/uvrC motif; Region: UVR; pfam02151 1107880001665 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1107880001666 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1107880001667 DNA binding site [nucleotide binding] 1107880001668 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1107880001669 GTP1/OBG; Region: GTP1_OBG; pfam01018 1107880001670 Obg GTPase; Region: Obg; cd01898 1107880001671 G1 box; other site 1107880001672 GTP/Mg2+ binding site [chemical binding]; other site 1107880001673 Switch I region; other site 1107880001674 G2 box; other site 1107880001675 G3 box; other site 1107880001676 Switch II region; other site 1107880001677 G4 box; other site 1107880001678 G5 box; other site 1107880001679 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1107880001680 acetolactate synthase; Reviewed; Region: PRK08617 1107880001681 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1107880001682 PYR/PP interface [polypeptide binding]; other site 1107880001683 dimer interface [polypeptide binding]; other site 1107880001684 TPP binding site [chemical binding]; other site 1107880001685 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1107880001686 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1107880001687 TPP-binding site [chemical binding]; other site 1107880001688 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1107880001689 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1107880001690 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 1107880001691 active site 1107880001692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1107880001693 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1107880001694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1107880001695 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1107880001696 ATP binding site [chemical binding]; other site 1107880001697 putative Mg++ binding site [ion binding]; other site 1107880001698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880001699 nucleotide binding region [chemical binding]; other site 1107880001700 ATP-binding site [chemical binding]; other site 1107880001701 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1107880001702 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1107880001703 DNA binding site [nucleotide binding] 1107880001704 catalytic residue [active] 1107880001705 H2TH interface [polypeptide binding]; other site 1107880001706 putative catalytic residues [active] 1107880001707 turnover-facilitating residue; other site 1107880001708 intercalation triad [nucleotide binding]; other site 1107880001709 8OG recognition residue [nucleotide binding]; other site 1107880001710 putative reading head residues; other site 1107880001711 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1107880001712 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1107880001713 Protein of unknown function (DUF975); Region: DUF975; cl10504 1107880001714 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1107880001715 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1107880001716 CoA-binding site [chemical binding]; other site 1107880001717 ATP-binding [chemical binding]; other site 1107880001718 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1107880001719 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1107880001720 primosomal protein DnaI; Reviewed; Region: PRK08939 1107880001721 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1107880001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880001723 Walker A motif; other site 1107880001724 ATP binding site [chemical binding]; other site 1107880001725 Walker B motif; other site 1107880001726 YibE/F-like protein; Region: YibE_F; pfam07907 1107880001727 YibE/F-like protein; Region: YibE_F; pfam07907 1107880001728 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1107880001729 Y-family of DNA polymerases; Region: PolY; cl12025 1107880001730 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1107880001731 generic binding surface II; other site 1107880001732 ssDNA binding site; other site 1107880001733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880001734 ATP binding site [chemical binding]; other site 1107880001735 putative Mg++ binding site [ion binding]; other site 1107880001736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880001737 nucleotide binding region [chemical binding]; other site 1107880001738 ATP-binding site [chemical binding]; other site 1107880001739 putative phosphate acyltransferase; Provisional; Region: PRK05331 1107880001740 acyl carrier protein; Provisional; Region: acpP; PRK00982 1107880001741 hypothetical protein; Provisional; Region: PRK04351 1107880001742 SprT homologues; Region: SprT; cl01182 1107880001743 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1107880001744 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1107880001745 CAAX protease self-immunity; Region: Abi; pfam02517 1107880001746 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1107880001747 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1107880001748 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1107880001749 active site 1107880001750 catabolite control protein A; Region: ccpA; TIGR01481 1107880001751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880001752 DNA binding site [nucleotide binding] 1107880001753 domain linker motif; other site 1107880001754 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1107880001755 dimerization interface [polypeptide binding]; other site 1107880001756 effector binding site; other site 1107880001757 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1107880001758 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1107880001759 catalytic triad [active] 1107880001760 catalytic triad [active] 1107880001761 oxyanion hole [active] 1107880001762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880001763 putative substrate translocation pore; other site 1107880001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880001765 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1107880001766 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1107880001767 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1107880001768 EamA-like transporter family; Region: EamA; pfam00892 1107880001769 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1107880001770 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1107880001771 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1107880001772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1107880001773 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1107880001774 putative active site [active] 1107880001775 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1107880001776 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1107880001777 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1107880001778 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1107880001779 N- and C-terminal domain interface [polypeptide binding]; other site 1107880001780 active site 1107880001781 catalytic site [active] 1107880001782 metal binding site [ion binding]; metal-binding site 1107880001783 carbohydrate binding site [chemical binding]; other site 1107880001784 ATP binding site [chemical binding]; other site 1107880001785 GntP family permease; Region: GntP_permease; pfam02447 1107880001786 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1107880001787 amino acid transporter; Region: 2A0306; TIGR00909 1107880001788 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1107880001789 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1107880001790 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1107880001791 inhibitor-cofactor binding pocket; inhibition site 1107880001792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880001793 catalytic residue [active] 1107880001794 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1107880001795 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1107880001796 motif 1; other site 1107880001797 active site 1107880001798 motif 2; other site 1107880001799 motif 3; other site 1107880001800 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1107880001801 DHHA1 domain; Region: DHHA1; pfam02272 1107880001802 hypothetical protein; Provisional; Region: PRK05473 1107880001803 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1107880001804 hypothetical protein; Provisional; Region: PRK13678 1107880001805 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1107880001806 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1107880001807 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1107880001808 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1107880001809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880001810 Walker A/P-loop; other site 1107880001811 ATP binding site [chemical binding]; other site 1107880001812 Q-loop/lid; other site 1107880001813 ABC transporter signature motif; other site 1107880001814 Walker B; other site 1107880001815 D-loop; other site 1107880001816 H-loop/switch region; other site 1107880001817 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1107880001818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880001819 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1107880001820 Walker A/P-loop; other site 1107880001821 ATP binding site [chemical binding]; other site 1107880001822 Q-loop/lid; other site 1107880001823 ABC transporter signature motif; other site 1107880001824 Walker B; other site 1107880001825 D-loop; other site 1107880001826 H-loop/switch region; other site 1107880001827 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1107880001828 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1107880001829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880001830 Coenzyme A binding pocket [chemical binding]; other site 1107880001831 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1107880001832 Part of AAA domain; Region: AAA_19; pfam13245 1107880001833 Family description; Region: UvrD_C_2; pfam13538 1107880001834 hypothetical protein; Provisional; Region: PRK06762 1107880001835 AAA domain; Region: AAA_33; pfam13671 1107880001836 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1107880001837 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1107880001838 nucleotide binding pocket [chemical binding]; other site 1107880001839 K-X-D-G motif; other site 1107880001840 catalytic site [active] 1107880001841 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1107880001842 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1107880001843 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1107880001844 Dimer interface [polypeptide binding]; other site 1107880001845 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1107880001846 putative dimer interface [polypeptide binding]; other site 1107880001847 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1107880001848 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1107880001849 putative dimer interface [polypeptide binding]; other site 1107880001850 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1107880001851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880001852 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1107880001853 Walker A motif; other site 1107880001854 ATP binding site [chemical binding]; other site 1107880001855 Walker B motif; other site 1107880001856 arginine finger; other site 1107880001857 UvrB/uvrC motif; Region: UVR; pfam02151 1107880001858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880001859 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1107880001860 Walker A motif; other site 1107880001861 ATP binding site [chemical binding]; other site 1107880001862 Walker B motif; other site 1107880001863 arginine finger; other site 1107880001864 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1107880001865 rod shape-determining protein MreB; Provisional; Region: PRK13927 1107880001866 MreB and similar proteins; Region: MreB_like; cd10225 1107880001867 nucleotide binding site [chemical binding]; other site 1107880001868 Mg binding site [ion binding]; other site 1107880001869 putative protofilament interaction site [polypeptide binding]; other site 1107880001870 RodZ interaction site [polypeptide binding]; other site 1107880001871 rod shape-determining protein MreC; Provisional; Region: PRK13922 1107880001872 rod shape-determining protein MreC; Region: MreC; pfam04085 1107880001873 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1107880001874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001875 dimer interface [polypeptide binding]; other site 1107880001876 conserved gate region; other site 1107880001877 putative PBP binding loops; other site 1107880001878 ABC-ATPase subunit interface; other site 1107880001879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880001880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880001881 Walker A/P-loop; other site 1107880001882 ATP binding site [chemical binding]; other site 1107880001883 Q-loop/lid; other site 1107880001884 ABC transporter signature motif; other site 1107880001885 Walker B; other site 1107880001886 D-loop; other site 1107880001887 H-loop/switch region; other site 1107880001888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880001889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880001890 substrate binding pocket [chemical binding]; other site 1107880001891 membrane-bound complex binding site; other site 1107880001892 hinge residues; other site 1107880001893 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1107880001894 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1107880001895 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1107880001896 putative active site [active] 1107880001897 catalytic site [active] 1107880001898 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1107880001899 putative active site [active] 1107880001900 catalytic site [active] 1107880001901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1107880001902 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1107880001903 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1107880001904 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1107880001905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1107880001906 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1107880001907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880001908 non-specific DNA binding site [nucleotide binding]; other site 1107880001909 salt bridge; other site 1107880001910 sequence-specific DNA binding site [nucleotide binding]; other site 1107880001911 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1107880001912 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1107880001913 recombinase A; Provisional; Region: recA; PRK09354 1107880001914 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1107880001915 hexamer interface [polypeptide binding]; other site 1107880001916 Walker A motif; other site 1107880001917 ATP binding site [chemical binding]; other site 1107880001918 Walker B motif; other site 1107880001919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880001920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880001921 active site 1107880001922 phosphorylation site [posttranslational modification] 1107880001923 intermolecular recognition site; other site 1107880001924 dimerization interface [polypeptide binding]; other site 1107880001925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880001926 DNA binding site [nucleotide binding] 1107880001927 PBP superfamily domain; Region: PBP_like_2; cl17296 1107880001928 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1107880001929 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1107880001930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1107880001931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880001932 dimer interface [polypeptide binding]; other site 1107880001933 phosphorylation site [posttranslational modification] 1107880001934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880001935 ATP binding site [chemical binding]; other site 1107880001936 Mg2+ binding site [ion binding]; other site 1107880001937 G-X-G motif; other site 1107880001938 PBP superfamily domain; Region: PBP_like_2; cl17296 1107880001939 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1107880001940 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1107880001941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001942 dimer interface [polypeptide binding]; other site 1107880001943 conserved gate region; other site 1107880001944 putative PBP binding loops; other site 1107880001945 ABC-ATPase subunit interface; other site 1107880001946 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1107880001947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880001948 dimer interface [polypeptide binding]; other site 1107880001949 conserved gate region; other site 1107880001950 putative PBP binding loops; other site 1107880001951 ABC-ATPase subunit interface; other site 1107880001952 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1107880001953 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1107880001954 Walker A/P-loop; other site 1107880001955 ATP binding site [chemical binding]; other site 1107880001956 Q-loop/lid; other site 1107880001957 ABC transporter signature motif; other site 1107880001958 Walker B; other site 1107880001959 D-loop; other site 1107880001960 H-loop/switch region; other site 1107880001961 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1107880001962 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1107880001963 Walker A/P-loop; other site 1107880001964 ATP binding site [chemical binding]; other site 1107880001965 Q-loop/lid; other site 1107880001966 ABC transporter signature motif; other site 1107880001967 Walker B; other site 1107880001968 D-loop; other site 1107880001969 H-loop/switch region; other site 1107880001970 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1107880001971 PhoU domain; Region: PhoU; pfam01895 1107880001972 PhoU domain; Region: PhoU; pfam01895 1107880001973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1107880001974 transmembrane helices; other site 1107880001975 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1107880001976 Membrane protein of unknown function; Region: DUF360; pfam04020 1107880001977 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1107880001978 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1107880001979 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1107880001980 Hpr binding site; other site 1107880001981 active site 1107880001982 homohexamer subunit interaction site [polypeptide binding]; other site 1107880001983 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1107880001984 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1107880001985 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1107880001986 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1107880001987 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1107880001988 active site 1107880001989 tetramer interface; other site 1107880001990 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1107880001991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880001992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880001993 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1107880001994 active site 1107880001995 metal binding site [ion binding]; metal-binding site 1107880001996 Predicted membrane protein [Function unknown]; Region: COG2364 1107880001997 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1107880001998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1107880001999 putative NAD(P) binding site [chemical binding]; other site 1107880002000 catalytic Zn binding site [ion binding]; other site 1107880002001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880002002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880002003 DNA binding site [nucleotide binding] 1107880002004 domain linker motif; other site 1107880002005 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1107880002006 dimerization interface [polypeptide binding]; other site 1107880002007 ligand binding site [chemical binding]; other site 1107880002008 sodium binding site [ion binding]; other site 1107880002009 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1107880002010 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1107880002011 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1107880002012 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1107880002013 active site 1107880002014 substrate binding site [chemical binding]; other site 1107880002015 metal binding site [ion binding]; metal-binding site 1107880002016 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1107880002017 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1107880002018 glutamate racemase; Provisional; Region: PRK00865 1107880002019 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1107880002020 active site 1107880002021 dimerization interface [polypeptide binding]; other site 1107880002022 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1107880002023 active site 1107880002024 metal binding site [ion binding]; metal-binding site 1107880002025 homotetramer interface [polypeptide binding]; other site 1107880002026 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1107880002027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880002028 Walker A motif; other site 1107880002029 ATP binding site [chemical binding]; other site 1107880002030 Walker B motif; other site 1107880002031 arginine finger; other site 1107880002032 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1107880002033 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1107880002034 putative active site [active] 1107880002035 putative metal binding site [ion binding]; other site 1107880002036 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1107880002037 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1107880002038 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002039 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1107880002040 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1107880002041 putative active site [active] 1107880002042 catalytic site [active] 1107880002043 putative metal binding site [ion binding]; other site 1107880002044 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1107880002045 RuvA N terminal domain; Region: RuvA_N; pfam01330 1107880002046 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1107880002047 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1107880002048 Substrate-binding site [chemical binding]; other site 1107880002049 Substrate specificity [chemical binding]; other site 1107880002050 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1107880002051 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1107880002052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1107880002053 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1107880002054 FtsX-like permease family; Region: FtsX; pfam02687 1107880002055 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880002056 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1107880002057 Walker A/P-loop; other site 1107880002058 ATP binding site [chemical binding]; other site 1107880002059 Q-loop/lid; other site 1107880002060 ABC transporter signature motif; other site 1107880002061 Walker B; other site 1107880002062 D-loop; other site 1107880002063 H-loop/switch region; other site 1107880002064 Predicted membrane protein [Function unknown]; Region: COG4684 1107880002065 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1107880002066 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1107880002067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1107880002068 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1107880002069 elongation factor Tu; Reviewed; Region: PRK00049 1107880002070 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1107880002071 G1 box; other site 1107880002072 GEF interaction site [polypeptide binding]; other site 1107880002073 GTP/Mg2+ binding site [chemical binding]; other site 1107880002074 Switch I region; other site 1107880002075 G2 box; other site 1107880002076 G3 box; other site 1107880002077 Switch II region; other site 1107880002078 G4 box; other site 1107880002079 G5 box; other site 1107880002080 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1107880002081 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1107880002082 Antibiotic Binding Site [chemical binding]; other site 1107880002083 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880002084 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880002085 Walker A/P-loop; other site 1107880002086 ATP binding site [chemical binding]; other site 1107880002087 Q-loop/lid; other site 1107880002088 ABC transporter signature motif; other site 1107880002089 Walker B; other site 1107880002090 D-loop; other site 1107880002091 H-loop/switch region; other site 1107880002092 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1107880002093 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1107880002094 active site 1107880002095 dimer interface [polypeptide binding]; other site 1107880002096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1107880002097 Ligand Binding Site [chemical binding]; other site 1107880002098 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1107880002099 active site 1107880002100 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1107880002101 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1107880002102 active site 1107880002103 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1107880002104 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1107880002105 HIGH motif; other site 1107880002106 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1107880002107 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1107880002108 active site 1107880002109 KMSKS motif; other site 1107880002110 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1107880002111 tRNA binding surface [nucleotide binding]; other site 1107880002112 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1107880002113 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1107880002114 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1107880002115 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1107880002116 heat shock protein HtpX; Provisional; Region: PRK04897 1107880002117 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1107880002118 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880002119 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880002120 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1107880002121 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1107880002122 active site 1 [active] 1107880002123 dimer interface [polypeptide binding]; other site 1107880002124 hexamer interface [polypeptide binding]; other site 1107880002125 active site 2 [active] 1107880002126 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1107880002127 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880002128 NlpC/P60 family; Region: NLPC_P60; pfam00877 1107880002129 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1107880002130 CsbD-like; Region: CsbD; pfam05532 1107880002131 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1107880002132 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1107880002133 active site 1107880002134 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1107880002135 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1107880002136 phosphate binding site [ion binding]; other site 1107880002137 GMP synthase; Reviewed; Region: guaA; PRK00074 1107880002138 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1107880002139 AMP/PPi binding site [chemical binding]; other site 1107880002140 candidate oxyanion hole; other site 1107880002141 catalytic triad [active] 1107880002142 potential glutamine specificity residues [chemical binding]; other site 1107880002143 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1107880002144 ATP Binding subdomain [chemical binding]; other site 1107880002145 Dimerization subdomain; other site 1107880002146 CsbD-like; Region: CsbD; pfam05532 1107880002147 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1107880002148 Transglycosylase; Region: Transgly; pfam00912 1107880002149 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1107880002150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1107880002151 hypothetical protein; Provisional; Region: PRK13660 1107880002152 cell division protein GpsB; Provisional; Region: PRK14127 1107880002153 DivIVA domain; Region: DivI1A_domain; TIGR03544 1107880002154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880002155 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880002156 substrate binding pocket [chemical binding]; other site 1107880002157 membrane-bound complex binding site; other site 1107880002158 hinge residues; other site 1107880002159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880002160 dimer interface [polypeptide binding]; other site 1107880002161 conserved gate region; other site 1107880002162 ABC-ATPase subunit interface; other site 1107880002163 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1107880002164 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1107880002165 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1107880002166 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1107880002167 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1107880002168 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1107880002169 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1107880002170 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1107880002171 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1107880002172 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1107880002173 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1107880002174 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1107880002175 active site 1107880002176 dimer interface [polypeptide binding]; other site 1107880002177 motif 1; other site 1107880002178 motif 2; other site 1107880002179 motif 3; other site 1107880002180 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1107880002181 anticodon binding site; other site 1107880002182 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1107880002183 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1107880002184 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1107880002185 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1107880002186 Phosphotransferase enzyme family; Region: APH; pfam01636 1107880002187 active site 1107880002188 ATP binding site [chemical binding]; other site 1107880002189 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1107880002190 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1107880002191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1107880002192 active site 1107880002193 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1107880002194 substrate binding site [chemical binding]; other site 1107880002195 catalytic residues [active] 1107880002196 dimer interface [polypeptide binding]; other site 1107880002197 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1107880002198 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1107880002199 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1107880002200 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1107880002201 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1107880002202 metal binding site [ion binding]; metal-binding site 1107880002203 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1107880002204 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1107880002205 dimer interface [polypeptide binding]; other site 1107880002206 active site 1107880002207 catalytic residue [active] 1107880002208 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1107880002209 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1107880002210 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1107880002211 RecX family; Region: RecX; cl00936 1107880002212 hypothetical protein; Provisional; Region: PRK13662 1107880002213 Rhomboid family; Region: Rhomboid; pfam01694 1107880002214 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1107880002215 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1107880002216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1107880002217 nucleotide binding site [chemical binding]; other site 1107880002218 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1107880002219 catalytic residues [active] 1107880002220 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1107880002221 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1107880002222 synthetase active site [active] 1107880002223 NTP binding site [chemical binding]; other site 1107880002224 metal binding site [ion binding]; metal-binding site 1107880002225 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1107880002226 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1107880002227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1107880002228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1107880002229 active site 1107880002230 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1107880002231 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1107880002232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1107880002233 Divalent cation transporter; Region: MgtE; pfam01769 1107880002234 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1107880002235 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1107880002236 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1107880002237 active site 1107880002238 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1107880002239 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1107880002240 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1107880002241 glutaminase active site [active] 1107880002242 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1107880002243 dimer interface [polypeptide binding]; other site 1107880002244 active site 1107880002245 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1107880002246 dimer interface [polypeptide binding]; other site 1107880002247 active site 1107880002248 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1107880002249 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1107880002250 catalytic residue [active] 1107880002251 putative FPP diphosphate binding site; other site 1107880002252 putative FPP binding hydrophobic cleft; other site 1107880002253 dimer interface [polypeptide binding]; other site 1107880002254 putative IPP diphosphate binding site; other site 1107880002255 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1107880002256 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1107880002257 RIP metalloprotease RseP; Region: TIGR00054 1107880002258 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1107880002259 active site 1107880002260 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1107880002261 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1107880002262 protein binding site [polypeptide binding]; other site 1107880002263 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1107880002264 putative substrate binding region [chemical binding]; other site 1107880002265 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1107880002266 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1107880002267 dimer interface [polypeptide binding]; other site 1107880002268 motif 1; other site 1107880002269 active site 1107880002270 motif 2; other site 1107880002271 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1107880002272 putative deacylase active site [active] 1107880002273 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1107880002274 active site 1107880002275 motif 3; other site 1107880002276 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1107880002277 anticodon binding site; other site 1107880002278 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1107880002279 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1107880002280 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1107880002281 generic binding surface II; other site 1107880002282 generic binding surface I; other site 1107880002283 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1107880002284 active site 1107880002285 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1107880002286 active site 1107880002287 catalytic site [active] 1107880002288 substrate binding site [chemical binding]; other site 1107880002289 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1107880002290 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1107880002291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1107880002292 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1107880002293 substrate binding site [chemical binding]; other site 1107880002294 dimer interface [polypeptide binding]; other site 1107880002295 ATP binding site [chemical binding]; other site 1107880002296 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1107880002297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880002298 S-adenosylmethionine binding site [chemical binding]; other site 1107880002299 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1107880002300 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1107880002301 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1107880002302 ligand binding site [chemical binding]; other site 1107880002303 Putative amino acid metabolism; Region: DUF1831; pfam08866 1107880002304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880002305 catalytic core [active] 1107880002306 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1107880002307 AAA domain; Region: AAA_30; pfam13604 1107880002308 Family description; Region: UvrD_C_2; pfam13538 1107880002309 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1107880002310 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1107880002311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880002312 active site 1107880002313 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1107880002314 active site 1107880002315 catalytic triad [active] 1107880002316 oxyanion hole [active] 1107880002317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880002318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880002319 active site 1107880002320 catalytic tetrad [active] 1107880002321 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1107880002322 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1107880002323 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1107880002324 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1107880002325 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1107880002326 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1107880002327 Potassium binding sites [ion binding]; other site 1107880002328 Cesium cation binding sites [ion binding]; other site 1107880002329 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1107880002330 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1107880002331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1107880002332 DNA-binding site [nucleotide binding]; DNA binding site 1107880002333 RNA-binding motif; other site 1107880002334 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1107880002335 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1107880002336 dimer interface [polypeptide binding]; other site 1107880002337 ADP-ribose binding site [chemical binding]; other site 1107880002338 active site 1107880002339 nudix motif; other site 1107880002340 metal binding site [ion binding]; metal-binding site 1107880002341 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1107880002342 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1107880002343 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1107880002344 putative tRNA-binding site [nucleotide binding]; other site 1107880002345 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 1107880002346 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1107880002347 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1107880002348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880002349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1107880002350 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1107880002351 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1107880002352 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1107880002353 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1107880002354 substrate binding [chemical binding]; other site 1107880002355 active site 1107880002356 DNA polymerase I; Provisional; Region: PRK05755 1107880002357 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1107880002358 active site 1107880002359 metal binding site 1 [ion binding]; metal-binding site 1107880002360 putative 5' ssDNA interaction site; other site 1107880002361 metal binding site 3; metal-binding site 1107880002362 metal binding site 2 [ion binding]; metal-binding site 1107880002363 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1107880002364 putative DNA binding site [nucleotide binding]; other site 1107880002365 putative metal binding site [ion binding]; other site 1107880002366 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1107880002367 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1107880002368 active site 1107880002369 DNA binding site [nucleotide binding] 1107880002370 catalytic site [active] 1107880002371 Intracellular septation protein A; Region: IspA; cl01098 1107880002372 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1107880002373 active site 1107880002374 catalytic site [active] 1107880002375 Domain of unknown function DUF87; Region: DUF87; pfam01935 1107880002376 AAA-like domain; Region: AAA_10; pfam12846 1107880002377 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1107880002378 DNA binding residues [nucleotide binding] 1107880002379 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1107880002380 putative dimer interface [polypeptide binding]; other site 1107880002381 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1107880002382 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1107880002383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1107880002384 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1107880002385 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1107880002386 ATP-grasp domain; Region: ATP-grasp; pfam02222 1107880002387 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1107880002388 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1107880002389 ATP binding site [chemical binding]; other site 1107880002390 active site 1107880002391 substrate binding site [chemical binding]; other site 1107880002392 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1107880002393 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1107880002394 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1107880002395 putative active site [active] 1107880002396 catalytic triad [active] 1107880002397 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1107880002398 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1107880002399 dimerization interface [polypeptide binding]; other site 1107880002400 ATP binding site [chemical binding]; other site 1107880002401 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1107880002402 dimerization interface [polypeptide binding]; other site 1107880002403 ATP binding site [chemical binding]; other site 1107880002404 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1107880002405 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1107880002406 active site 1107880002407 tetramer interface [polypeptide binding]; other site 1107880002408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880002409 active site 1107880002410 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1107880002411 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1107880002412 dimerization interface [polypeptide binding]; other site 1107880002413 putative ATP binding site [chemical binding]; other site 1107880002414 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1107880002415 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1107880002416 active site 1107880002417 substrate binding site [chemical binding]; other site 1107880002418 cosubstrate binding site; other site 1107880002419 catalytic site [active] 1107880002420 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1107880002421 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1107880002422 purine monophosphate binding site [chemical binding]; other site 1107880002423 dimer interface [polypeptide binding]; other site 1107880002424 putative catalytic residues [active] 1107880002425 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1107880002426 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1107880002427 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1107880002428 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1107880002429 active site 1107880002430 metal binding site [ion binding]; metal-binding site 1107880002431 DNA binding site [nucleotide binding] 1107880002432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880002433 AAA domain; Region: AAA_23; pfam13476 1107880002434 Walker A/P-loop; other site 1107880002435 ATP binding site [chemical binding]; other site 1107880002436 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1107880002437 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1107880002438 generic binding surface II; other site 1107880002439 generic binding surface I; other site 1107880002440 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1107880002441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880002442 Zn2+ binding site [ion binding]; other site 1107880002443 Mg2+ binding site [ion binding]; other site 1107880002444 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1107880002445 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1107880002446 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1107880002447 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1107880002448 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1107880002449 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1107880002450 FMN binding site [chemical binding]; other site 1107880002451 active site 1107880002452 catalytic residues [active] 1107880002453 substrate binding site [chemical binding]; other site 1107880002454 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1107880002455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880002456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1107880002457 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1107880002458 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1107880002459 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1107880002460 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1107880002461 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1107880002462 tetramer interface [polypeptide binding]; other site 1107880002463 TPP-binding site [chemical binding]; other site 1107880002464 heterodimer interface [polypeptide binding]; other site 1107880002465 phosphorylation loop region [posttranslational modification] 1107880002466 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1107880002467 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1107880002468 alpha subunit interface [polypeptide binding]; other site 1107880002469 TPP binding site [chemical binding]; other site 1107880002470 heterodimer interface [polypeptide binding]; other site 1107880002471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1107880002472 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1107880002473 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1107880002474 E3 interaction surface; other site 1107880002475 lipoyl attachment site [posttranslational modification]; other site 1107880002476 e3 binding domain; Region: E3_binding; pfam02817 1107880002477 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1107880002478 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1107880002479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1107880002480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880002481 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880002482 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1107880002483 Lipase (class 2); Region: Lipase_2; pfam01674 1107880002484 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1107880002485 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1107880002486 active site 1107880002487 catalytic site [active] 1107880002488 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1107880002489 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1107880002490 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1107880002491 DNA topoisomerase I; Validated; Region: PRK05582 1107880002492 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1107880002493 active site 1107880002494 interdomain interaction site; other site 1107880002495 putative metal-binding site [ion binding]; other site 1107880002496 nucleotide binding site [chemical binding]; other site 1107880002497 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1107880002498 domain I; other site 1107880002499 DNA binding groove [nucleotide binding] 1107880002500 phosphate binding site [ion binding]; other site 1107880002501 domain II; other site 1107880002502 domain III; other site 1107880002503 nucleotide binding site [chemical binding]; other site 1107880002504 catalytic site [active] 1107880002505 domain IV; other site 1107880002506 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1107880002507 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1107880002508 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1107880002509 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880002510 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880002511 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1107880002512 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1107880002513 dimer interface [polypeptide binding]; other site 1107880002514 substrate binding site [chemical binding]; other site 1107880002515 ATP binding site [chemical binding]; other site 1107880002516 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1107880002517 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1107880002518 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1107880002519 dimer interface [polypeptide binding]; other site 1107880002520 tetramer interface [polypeptide binding]; other site 1107880002521 PYR/PP interface [polypeptide binding]; other site 1107880002522 TPP binding site [chemical binding]; other site 1107880002523 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1107880002524 TPP-binding site; other site 1107880002525 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1107880002526 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1107880002527 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1107880002528 active site 1107880002529 octamer interface [polypeptide binding]; other site 1107880002530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1107880002531 binding surface 1107880002532 TPR motif; other site 1107880002533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1107880002534 binding surface 1107880002535 TPR motif; other site 1107880002536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1107880002537 binding surface 1107880002538 TPR motif; other site 1107880002539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1107880002540 TPR motif; other site 1107880002541 binding surface 1107880002542 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1107880002543 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1107880002544 active site 1107880002545 NTP binding site [chemical binding]; other site 1107880002546 metal binding triad [ion binding]; metal-binding site 1107880002547 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1107880002548 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1107880002549 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1107880002550 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1107880002551 folate binding site [chemical binding]; other site 1107880002552 NADP+ binding site [chemical binding]; other site 1107880002553 EDD domain protein, DegV family; Region: DegV; TIGR00762 1107880002554 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1107880002555 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1107880002556 active site 1107880002557 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1107880002558 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1107880002559 active site 1107880002560 catalytic triad [active] 1107880002561 oxyanion hole [active] 1107880002562 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1107880002563 hypothetical protein; Provisional; Region: PRK13672 1107880002564 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1107880002565 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1107880002566 GTP/Mg2+ binding site [chemical binding]; other site 1107880002567 G4 box; other site 1107880002568 G5 box; other site 1107880002569 G1 box; other site 1107880002570 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1107880002571 GTP/Mg2+ binding site [chemical binding]; other site 1107880002572 G1 box; other site 1107880002573 Switch I region; other site 1107880002574 G2 box; other site 1107880002575 G2 box; other site 1107880002576 G3 box; other site 1107880002577 G3 box; other site 1107880002578 Switch II region; other site 1107880002579 Switch II region; other site 1107880002580 G4 box; other site 1107880002581 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1107880002582 RNA/DNA hybrid binding site [nucleotide binding]; other site 1107880002583 active site 1107880002584 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1107880002585 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1107880002586 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880002587 Walker A/P-loop; other site 1107880002588 ATP binding site [chemical binding]; other site 1107880002589 Q-loop/lid; other site 1107880002590 ABC transporter signature motif; other site 1107880002591 Walker B; other site 1107880002592 D-loop; other site 1107880002593 H-loop/switch region; other site 1107880002594 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1107880002595 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880002596 Walker A/P-loop; other site 1107880002597 ATP binding site [chemical binding]; other site 1107880002598 Q-loop/lid; other site 1107880002599 ABC transporter signature motif; other site 1107880002600 Walker B; other site 1107880002601 D-loop; other site 1107880002602 H-loop/switch region; other site 1107880002603 Domain of unknown function DUF77; Region: DUF77; pfam01910 1107880002604 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1107880002605 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1107880002606 Family of unknown function (DUF633); Region: DUF633; pfam04816 1107880002607 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1107880002608 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1107880002609 peptidase T; Region: peptidase-T; TIGR01882 1107880002610 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1107880002611 metal binding site [ion binding]; metal-binding site 1107880002612 dimer interface [polypeptide binding]; other site 1107880002613 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1107880002614 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1107880002615 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1107880002616 active site 1107880002617 PHP Thumb interface [polypeptide binding]; other site 1107880002618 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1107880002619 generic binding surface II; other site 1107880002620 generic binding surface I; other site 1107880002621 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1107880002622 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1107880002623 domain interfaces; other site 1107880002624 active site 1107880002625 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1107880002626 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1107880002627 PhoH-like protein; Region: PhoH; pfam02562 1107880002628 metal-binding heat shock protein; Provisional; Region: PRK00016 1107880002629 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1107880002630 GTPase Era; Reviewed; Region: era; PRK00089 1107880002631 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1107880002632 G1 box; other site 1107880002633 GTP/Mg2+ binding site [chemical binding]; other site 1107880002634 Switch I region; other site 1107880002635 G2 box; other site 1107880002636 Switch II region; other site 1107880002637 G3 box; other site 1107880002638 G4 box; other site 1107880002639 G5 box; other site 1107880002640 KH domain; Region: KH_2; pfam07650 1107880002641 Recombination protein O N terminal; Region: RecO_N; pfam11967 1107880002642 DNA repair protein RecO; Region: reco; TIGR00613 1107880002643 Recombination protein O C terminal; Region: RecO_C; pfam02565 1107880002644 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1107880002645 active site 1107880002646 homotetramer interface [polypeptide binding]; other site 1107880002647 homodimer interface [polypeptide binding]; other site 1107880002648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880002649 catalytic core [active] 1107880002650 aspartate kinase; Reviewed; Region: PRK09034 1107880002651 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1107880002652 putative catalytic residues [active] 1107880002653 putative nucleotide binding site [chemical binding]; other site 1107880002654 putative aspartate binding site [chemical binding]; other site 1107880002655 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1107880002656 allosteric regulatory residue; other site 1107880002657 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1107880002658 homoserine kinase; Provisional; Region: PRK01212 1107880002659 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1107880002660 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1107880002661 homoserine dehydrogenase; Provisional; Region: PRK06349 1107880002662 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1107880002663 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1107880002664 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1107880002665 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1107880002666 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1107880002667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880002668 catalytic residue [active] 1107880002669 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1107880002670 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1107880002671 dimer interface [polypeptide binding]; other site 1107880002672 active site 1107880002673 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1107880002674 folate binding site [chemical binding]; other site 1107880002675 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1107880002676 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1107880002677 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1107880002678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880002679 S-adenosylmethionine binding site [chemical binding]; other site 1107880002680 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880002681 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880002682 active site 1107880002683 catalytic tetrad [active] 1107880002684 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1107880002685 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1107880002686 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1107880002687 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1107880002688 active site 1107880002689 dimer interface [polypeptide binding]; other site 1107880002690 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1107880002691 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1107880002692 substrate binding site [chemical binding]; other site 1107880002693 dimer interface [polypeptide binding]; other site 1107880002694 ATP binding site [chemical binding]; other site 1107880002695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880002696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880002697 DNA binding site [nucleotide binding] 1107880002698 domain linker motif; other site 1107880002699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1107880002700 dimerization interface [polypeptide binding]; other site 1107880002701 ligand binding site [chemical binding]; other site 1107880002702 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1107880002703 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1107880002704 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1107880002705 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1107880002706 active site 1107880002707 tetramer interface [polypeptide binding]; other site 1107880002708 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1107880002709 active site 1107880002710 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1107880002711 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1107880002712 putative ion selectivity filter; other site 1107880002713 putative pore gating glutamate residue; other site 1107880002714 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1107880002715 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1107880002716 putative active site [active] 1107880002717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1107880002718 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1107880002719 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1107880002720 ferric uptake regulator; Provisional; Region: fur; PRK09462 1107880002721 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1107880002722 metal binding site 2 [ion binding]; metal-binding site 1107880002723 putative DNA binding helix; other site 1107880002724 metal binding site 1 [ion binding]; metal-binding site 1107880002725 dimer interface [polypeptide binding]; other site 1107880002726 structural Zn2+ binding site [ion binding]; other site 1107880002727 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1107880002728 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1107880002729 metal binding site [ion binding]; metal-binding site 1107880002730 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1107880002731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880002732 Walker A/P-loop; other site 1107880002733 ATP binding site [chemical binding]; other site 1107880002734 Q-loop/lid; other site 1107880002735 ABC transporter signature motif; other site 1107880002736 Walker B; other site 1107880002737 D-loop; other site 1107880002738 H-loop/switch region; other site 1107880002739 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1107880002740 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1107880002741 ABC-ATPase subunit interface; other site 1107880002742 dimer interface [polypeptide binding]; other site 1107880002743 putative PBP binding regions; other site 1107880002744 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1107880002745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880002746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880002747 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880002748 Predicted integral membrane protein [Function unknown]; Region: COG5617 1107880002749 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1107880002750 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1107880002751 active site 1107880002752 purine riboside binding site [chemical binding]; other site 1107880002753 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1107880002754 DNA photolyase; Region: DNA_photolyase; pfam00875 1107880002755 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1107880002756 FtsX-like permease family; Region: FtsX; pfam02687 1107880002757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880002758 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1107880002759 Walker A/P-loop; other site 1107880002760 ATP binding site [chemical binding]; other site 1107880002761 Q-loop/lid; other site 1107880002762 ABC transporter signature motif; other site 1107880002763 Walker B; other site 1107880002764 D-loop; other site 1107880002765 H-loop/switch region; other site 1107880002766 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1107880002767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880002768 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1107880002769 MMPL family; Region: MMPL; pfam03176 1107880002770 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1107880002771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1107880002772 Ligand Binding Site [chemical binding]; other site 1107880002773 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1107880002774 pentamer interface [polypeptide binding]; other site 1107880002775 dodecaamer interface [polypeptide binding]; other site 1107880002776 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1107880002777 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1107880002778 active site 1107880002779 dimer interface [polypeptide binding]; other site 1107880002780 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1107880002781 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1107880002782 active site 1107880002783 FMN binding site [chemical binding]; other site 1107880002784 substrate binding site [chemical binding]; other site 1107880002785 3Fe-4S cluster binding site [ion binding]; other site 1107880002786 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1107880002787 domain interface; other site 1107880002788 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1107880002789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1107880002790 Cation efflux family; Region: Cation_efflux; pfam01545 1107880002791 Amidinotransferase; Region: Amidinotransf; cl12043 1107880002792 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1107880002793 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1107880002794 catalytic motif [active] 1107880002795 Zn binding site [ion binding]; other site 1107880002796 RibD C-terminal domain; Region: RibD_C; pfam01872 1107880002797 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1107880002798 Lumazine binding domain; Region: Lum_binding; pfam00677 1107880002799 Lumazine binding domain; Region: Lum_binding; pfam00677 1107880002800 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1107880002801 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1107880002802 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1107880002803 dimerization interface [polypeptide binding]; other site 1107880002804 active site 1107880002805 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1107880002806 homopentamer interface [polypeptide binding]; other site 1107880002807 active site 1107880002808 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1107880002809 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1107880002810 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1107880002811 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1107880002812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880002813 motif II; other site 1107880002814 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1107880002815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880002817 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1107880002818 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1107880002819 Ca binding site [ion binding]; other site 1107880002820 active site 1107880002821 catalytic site [active] 1107880002822 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1107880002823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880002824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880002825 DNA binding site [nucleotide binding] 1107880002826 domain linker motif; other site 1107880002827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1107880002828 dimerization interface [polypeptide binding]; other site 1107880002829 ligand binding site [chemical binding]; other site 1107880002830 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1107880002831 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1107880002832 conserved cys residue [active] 1107880002833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880002834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880002835 active site 1107880002836 phosphorylation site [posttranslational modification] 1107880002837 intermolecular recognition site; other site 1107880002838 dimerization interface [polypeptide binding]; other site 1107880002839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880002840 DNA binding site [nucleotide binding] 1107880002841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1107880002842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880002843 ATP binding site [chemical binding]; other site 1107880002844 Mg2+ binding site [ion binding]; other site 1107880002845 G-X-G motif; other site 1107880002846 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880002847 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1107880002848 Walker A/P-loop; other site 1107880002849 ATP binding site [chemical binding]; other site 1107880002850 Q-loop/lid; other site 1107880002851 ABC transporter signature motif; other site 1107880002852 Walker B; other site 1107880002853 D-loop; other site 1107880002854 H-loop/switch region; other site 1107880002855 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1107880002856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1107880002857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1107880002858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1107880002859 dimerization interface [polypeptide binding]; other site 1107880002860 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1107880002861 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1107880002862 inhibitor-cofactor binding pocket; inhibition site 1107880002863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880002864 catalytic residue [active] 1107880002865 serine O-acetyltransferase; Region: cysE; TIGR01172 1107880002866 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1107880002867 trimer interface [polypeptide binding]; other site 1107880002868 active site 1107880002869 substrate binding site [chemical binding]; other site 1107880002870 CoA binding site [chemical binding]; other site 1107880002871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1107880002872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880002873 Coenzyme A binding pocket [chemical binding]; other site 1107880002874 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880002875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880002876 active site 1107880002877 catalytic tetrad [active] 1107880002878 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1107880002879 nudix motif; other site 1107880002880 potential frameshift: common BLAST hit: gi|116617954|ref|YP_818325.1| AraC family transcriptional regulator 1107880002881 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1107880002882 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1107880002883 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1107880002884 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1107880002885 MFS/sugar transport protein; Region: MFS_2; pfam13347 1107880002886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002887 putative substrate translocation pore; other site 1107880002888 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1107880002889 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1107880002890 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1107880002891 inhibitor binding site; inhibition site 1107880002892 active site 1107880002893 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1107880002894 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1107880002895 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1107880002896 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1107880002897 DNA binding residues [nucleotide binding] 1107880002898 CAAX protease self-immunity; Region: Abi; pfam02517 1107880002899 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1107880002900 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1107880002901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880002902 DNA-binding site [nucleotide binding]; DNA binding site 1107880002903 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1107880002904 putative dimerization interface [polypeptide binding]; other site 1107880002905 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1107880002906 putative ligand binding site [chemical binding]; other site 1107880002907 L-arabinose isomerase; Provisional; Region: PRK02929 1107880002908 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1107880002909 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1107880002910 trimer interface [polypeptide binding]; other site 1107880002911 substrate binding site [chemical binding]; other site 1107880002912 Mn binding site [ion binding]; other site 1107880002913 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1107880002914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002915 putative substrate translocation pore; other site 1107880002916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002917 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1107880002918 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1107880002919 putative N- and C-terminal domain interface [polypeptide binding]; other site 1107880002920 putative active site [active] 1107880002921 MgATP binding site [chemical binding]; other site 1107880002922 catalytic site [active] 1107880002923 metal binding site [ion binding]; metal-binding site 1107880002924 putative carbohydrate binding site [chemical binding]; other site 1107880002925 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1107880002926 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1107880002927 intersubunit interface [polypeptide binding]; other site 1107880002928 active site 1107880002929 Zn2+ binding site [ion binding]; other site 1107880002930 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880002931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880002932 non-specific DNA binding site [nucleotide binding]; other site 1107880002933 salt bridge; other site 1107880002934 sequence-specific DNA binding site [nucleotide binding]; other site 1107880002935 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1107880002936 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1107880002937 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880002938 active site 1107880002939 catalytic site [active] 1107880002940 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880002941 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 1107880002942 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002943 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002944 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002945 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002946 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002947 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002948 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002949 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002950 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002951 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002952 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880002953 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1107880002954 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880002955 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880002956 oxidoreductase; Provisional; Region: PRK07985 1107880002957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880002958 NAD(P) binding site [chemical binding]; other site 1107880002959 active site 1107880002960 Predicted membrane protein [Function unknown]; Region: COG2261 1107880002961 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1107880002962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1107880002963 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1107880002964 Predicted membrane protein [Function unknown]; Region: COG2261 1107880002965 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880002966 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880002967 active site 1107880002968 catalytic tetrad [active] 1107880002969 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1107880002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002971 putative substrate translocation pore; other site 1107880002972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002973 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1107880002974 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1107880002975 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1107880002976 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1107880002977 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1107880002978 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1107880002979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1107880002980 Predicted flavoprotein [General function prediction only]; Region: COG0431 1107880002981 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1107880002982 CAAX protease self-immunity; Region: Abi; pfam02517 1107880002983 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1107880002984 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1107880002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880002986 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1107880002987 HPr interaction site; other site 1107880002988 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1107880002989 active site 1107880002990 phosphorylation site [posttranslational modification] 1107880002991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880002992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880002993 DNA binding site [nucleotide binding] 1107880002994 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1107880002995 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1107880002996 Melibiase; Region: Melibiase; pfam02065 1107880002997 galactokinase; Provisional; Region: PRK05322 1107880002998 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1107880002999 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1107880003000 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1107880003001 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1107880003002 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1107880003003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1107880003004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880003005 Walker A/P-loop; other site 1107880003006 ATP binding site [chemical binding]; other site 1107880003007 Q-loop/lid; other site 1107880003008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880003009 ABC transporter signature motif; other site 1107880003010 Walker B; other site 1107880003011 D-loop; other site 1107880003012 H-loop/switch region; other site 1107880003013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880003014 AAA domain; Region: AAA_21; pfam13304 1107880003015 Walker A/P-loop; other site 1107880003016 ATP binding site [chemical binding]; other site 1107880003017 Q-loop/lid; other site 1107880003018 ABC transporter signature motif; other site 1107880003019 Walker B; other site 1107880003020 D-loop; other site 1107880003021 H-loop/switch region; other site 1107880003022 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1107880003023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1107880003025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003026 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1107880003027 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1107880003028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880003029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880003030 DNA binding site [nucleotide binding] 1107880003031 domain linker motif; other site 1107880003032 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1107880003033 putative dimerization interface [polypeptide binding]; other site 1107880003034 putative ligand binding site [chemical binding]; other site 1107880003035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880003036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880003037 DNA binding site [nucleotide binding] 1107880003038 domain linker motif; other site 1107880003039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1107880003040 ligand binding site [chemical binding]; other site 1107880003041 dimerization interface [polypeptide binding]; other site 1107880003042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880003044 putative substrate translocation pore; other site 1107880003045 maltose phosphorylase; Provisional; Region: PRK13807 1107880003046 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1107880003047 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1107880003048 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1107880003049 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1107880003050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880003051 motif II; other site 1107880003052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880003053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880003054 DNA binding site [nucleotide binding] 1107880003055 domain linker motif; other site 1107880003056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1107880003057 dimerization interface [polypeptide binding]; other site 1107880003058 ligand binding site [chemical binding]; other site 1107880003059 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1107880003060 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1107880003061 Ca binding site [ion binding]; other site 1107880003062 active site 1107880003063 catalytic site [active] 1107880003064 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1107880003065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003066 putative substrate translocation pore; other site 1107880003067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880003068 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1107880003069 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1107880003070 Ca binding site [ion binding]; other site 1107880003071 active site 1107880003072 catalytic site [active] 1107880003073 CAT RNA binding domain; Region: CAT_RBD; smart01061 1107880003074 PRD domain; Region: PRD; pfam00874 1107880003075 potential frameshift: common BLAST hit: gi|116618010|ref|YP_818381.1| trehalose PTS trehalose component IIBC 1107880003076 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1107880003077 beta-galactosidase; Region: BGL; TIGR03356 1107880003078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1107880003079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880003080 Coenzyme A binding pocket [chemical binding]; other site 1107880003081 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1107880003082 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1107880003083 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1107880003084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880003085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880003086 DNA binding site [nucleotide binding] 1107880003087 domain linker motif; other site 1107880003088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1107880003089 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1107880003090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003091 putative substrate translocation pore; other site 1107880003092 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1107880003093 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1107880003094 Ca binding site [ion binding]; other site 1107880003095 active site 1107880003096 catalytic site [active] 1107880003097 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1107880003098 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 1107880003099 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1107880003100 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 1107880003101 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1107880003102 DXD motif; other site 1107880003103 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1107880003104 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1107880003105 conserved hypothetical integral membrane protein; Region: TIGR03766 1107880003106 short chain dehydrogenase; Validated; Region: PRK06182 1107880003107 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1107880003108 NADP binding site [chemical binding]; other site 1107880003109 active site 1107880003110 steroid binding site; other site 1107880003111 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1107880003112 nudix motif; other site 1107880003113 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1107880003114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003115 benzoate transport; Region: 2A0115; TIGR00895 1107880003116 putative substrate translocation pore; other site 1107880003117 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1107880003118 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1107880003119 putative NAD(P) binding site [chemical binding]; other site 1107880003120 catalytic Zn binding site [ion binding]; other site 1107880003121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1107880003122 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1107880003123 Walker A/P-loop; other site 1107880003124 ATP binding site [chemical binding]; other site 1107880003125 Q-loop/lid; other site 1107880003126 ABC transporter signature motif; other site 1107880003127 Walker B; other site 1107880003128 D-loop; other site 1107880003129 H-loop/switch region; other site 1107880003130 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1107880003131 putative uracil binding site [chemical binding]; other site 1107880003132 putative active site [active] 1107880003133 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1107880003134 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1107880003135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880003136 active site 1107880003137 motif I; other site 1107880003138 motif II; other site 1107880003139 H+ Antiporter protein; Region: 2A0121; TIGR00900 1107880003140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003141 putative substrate translocation pore; other site 1107880003142 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1107880003143 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1107880003144 proposed catalytic triad [active] 1107880003145 conserved cys residue [active] 1107880003146 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1107880003147 aminotransferase A; Validated; Region: PRK07683 1107880003148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880003149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003150 homodimer interface [polypeptide binding]; other site 1107880003151 catalytic residue [active] 1107880003152 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1107880003153 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1107880003154 NADP binding site [chemical binding]; other site 1107880003155 homodimer interface [polypeptide binding]; other site 1107880003156 active site 1107880003157 GntP family permease; Region: GntP_permease; pfam02447 1107880003158 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1107880003159 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1107880003160 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1107880003161 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1107880003162 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1107880003163 putative dimer interface [polypeptide binding]; other site 1107880003164 catalytic triad [active] 1107880003165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1107880003166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880003167 Coenzyme A binding pocket [chemical binding]; other site 1107880003168 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1107880003169 beta-galactosidase; Region: BGL; TIGR03356 1107880003170 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 1107880003171 active site 1107880003172 P-loop; other site 1107880003173 phosphorylation site [posttranslational modification] 1107880003174 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1107880003175 Mga helix-turn-helix domain; Region: Mga; pfam05043 1107880003176 PRD domain; Region: PRD; pfam00874 1107880003177 PRD domain; Region: PRD; pfam00874 1107880003178 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1107880003179 active site 1107880003180 P-loop; other site 1107880003181 phosphorylation site [posttranslational modification] 1107880003182 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1107880003183 active site 1107880003184 phosphorylation site [posttranslational modification] 1107880003185 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1107880003186 methionine cluster; other site 1107880003187 active site 1107880003188 phosphorylation site [posttranslational modification] 1107880003189 metal binding site [ion binding]; metal-binding site 1107880003190 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1107880003191 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1107880003192 xanthine permease; Region: pbuX; TIGR03173 1107880003193 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1107880003194 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1107880003195 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1107880003196 putative catalytic cysteine [active] 1107880003197 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1107880003198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880003199 NAD(P) binding site [chemical binding]; other site 1107880003200 active site 1107880003201 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 1107880003202 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1107880003203 substrate binding site [chemical binding]; other site 1107880003204 multimerization interface [polypeptide binding]; other site 1107880003205 ATP binding site [chemical binding]; other site 1107880003206 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1107880003207 active site 1107880003208 P-loop; other site 1107880003209 phosphorylation site [posttranslational modification] 1107880003210 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1107880003211 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1107880003212 active site 1107880003213 methionine cluster; other site 1107880003214 phosphorylation site [posttranslational modification] 1107880003215 metal binding site [ion binding]; metal-binding site 1107880003216 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1107880003217 beta-galactosidase; Region: BGL; TIGR03356 1107880003218 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1107880003219 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1107880003220 Predicted transcriptional regulators [Transcription]; Region: COG1733 1107880003221 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1107880003222 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1107880003223 MarR family; Region: MarR; pfam01047 1107880003224 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1107880003225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880003226 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880003227 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1107880003228 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1107880003229 putative NAD(P) binding site [chemical binding]; other site 1107880003230 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1107880003231 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1107880003232 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1107880003233 Ligand binding site; other site 1107880003234 metal-binding site 1107880003235 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1107880003236 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1107880003237 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1107880003238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1107880003239 ABC-ATPase subunit interface; other site 1107880003240 dimer interface [polypeptide binding]; other site 1107880003241 putative PBP binding regions; other site 1107880003242 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1107880003243 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1107880003244 metal binding site [ion binding]; metal-binding site 1107880003245 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1107880003246 acyltransferase PapA5; Provisional; Region: PRK09294 1107880003247 potential frameshift: common BLAST hit: gi|116618064|ref|YP_818435.1| DNA-binding response regulator 1107880003248 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1107880003249 HAMP domain; Region: HAMP; pfam00672 1107880003250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880003251 dimer interface [polypeptide binding]; other site 1107880003252 phosphorylation site [posttranslational modification] 1107880003253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880003254 ATP binding site [chemical binding]; other site 1107880003255 Mg2+ binding site [ion binding]; other site 1107880003256 G-X-G motif; other site 1107880003257 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 1107880003258 Predicted membrane protein [Function unknown]; Region: COG3212 1107880003259 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1107880003260 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1107880003261 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1107880003262 MarR family; Region: MarR_2; pfam12802 1107880003263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880003265 putative substrate translocation pore; other site 1107880003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1107880003268 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1107880003269 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1107880003270 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1107880003271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880003272 motif II; other site 1107880003273 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1107880003274 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880003275 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880003276 active site 1107880003277 catalytic tetrad [active] 1107880003278 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1107880003279 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1107880003280 DNA binding residues [nucleotide binding] 1107880003281 putative dimer interface [polypeptide binding]; other site 1107880003282 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1107880003283 putative deacylase active site [active] 1107880003284 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1107880003285 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1107880003286 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1107880003287 putative ligand binding site [chemical binding]; other site 1107880003288 putative NAD binding site [chemical binding]; other site 1107880003289 catalytic site [active] 1107880003290 short chain dehydrogenase; Provisional; Region: PRK06180 1107880003291 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1107880003292 NADP binding site [chemical binding]; other site 1107880003293 active site 1107880003294 steroid binding site; other site 1107880003295 legume lectins; Region: lectin_L-type; cd01951 1107880003296 homotetramer interaction site [polypeptide binding]; other site 1107880003297 carbohydrate binding site [chemical binding]; other site 1107880003298 metal binding site [ion binding]; metal-binding site 1107880003299 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1107880003300 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1107880003301 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1107880003302 N-glycosyltransferase; Provisional; Region: PRK11204 1107880003303 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1107880003304 DXD motif; other site 1107880003305 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1107880003306 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1107880003307 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1107880003308 conserved cys residue [active] 1107880003309 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880003310 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880003311 DNA polymerase IV; Reviewed; Region: PRK03103 1107880003312 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1107880003313 active site 1107880003314 DNA binding site [nucleotide binding] 1107880003315 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1107880003316 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1107880003317 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1107880003318 PYR/PP interface [polypeptide binding]; other site 1107880003319 tetramer interface [polypeptide binding]; other site 1107880003320 dimer interface [polypeptide binding]; other site 1107880003321 TPP binding site [chemical binding]; other site 1107880003322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1107880003323 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1107880003324 TPP-binding site [chemical binding]; other site 1107880003325 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1107880003326 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1107880003327 putative dimer interface [polypeptide binding]; other site 1107880003328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880003329 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1107880003330 NAD(P) binding site [chemical binding]; other site 1107880003331 active site 1107880003332 potential frameshift: common BLAST hit: gi|289551807|ref|YP_003472711.1| LacI family transcriptinal regulator 1107880003333 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1107880003334 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1107880003335 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1107880003336 substrate binding [chemical binding]; other site 1107880003337 active site 1107880003338 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1107880003339 galactoside permease; Reviewed; Region: lacY; PRK09528 1107880003340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003341 potential frameshift: common BLAST hit: gi|116618172|ref|YP_818543.1| transposase 1107880003342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1107880003343 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1107880003344 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1107880003345 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1107880003346 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1107880003347 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1107880003348 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1107880003349 TIR domain; Region: TIR_2; pfam13676 1107880003350 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1107880003351 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1107880003352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1107880003353 ATP binding site [chemical binding]; other site 1107880003354 putative Mg++ binding site [ion binding]; other site 1107880003355 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1107880003356 Helix-turn-helix domain; Region: HTH_38; pfam13936 1107880003357 Integrase core domain; Region: rve; pfam00665 1107880003358 Predicted membrane protein [Function unknown]; Region: COG1511 1107880003359 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1107880003360 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1107880003361 Predicted transcriptional regulator [Transcription]; Region: COG1959 1107880003362 Transcriptional regulator; Region: Rrf2; pfam02082 1107880003363 Transcriptional regulator; Region: Rrf2; cl17282 1107880003364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880003366 putative substrate translocation pore; other site 1107880003367 tRNA dimethylallyltransferase; Region: PLN02840 1107880003368 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1107880003369 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1107880003370 active site 1107880003371 metal binding site [ion binding]; metal-binding site 1107880003372 interdomain interaction site; other site 1107880003373 Domain of unknown function (DUF955); Region: DUF955; cl01076 1107880003374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880003375 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1107880003376 Walker A motif; other site 1107880003377 ATP binding site [chemical binding]; other site 1107880003378 Walker B motif; other site 1107880003379 arginine finger; other site 1107880003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880003381 Walker A motif; other site 1107880003382 ATP binding site [chemical binding]; other site 1107880003383 Walker B motif; other site 1107880003384 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1107880003385 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1107880003386 Walker A motif; other site 1107880003387 ATP binding site [chemical binding]; other site 1107880003388 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1107880003389 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1107880003390 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1107880003391 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880003392 P-loop; other site 1107880003393 Magnesium ion binding site [ion binding]; other site 1107880003394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880003395 Magnesium ion binding site [ion binding]; other site 1107880003396 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1107880003397 AAA-like domain; Region: AAA_10; pfam12846 1107880003398 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1107880003399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1107880003400 Peptidase family M23; Region: Peptidase_M23; pfam01551 1107880003401 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880003402 catalytic residues [active] 1107880003403 Predicted membrane protein [Function unknown]; Region: COG2364 1107880003404 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1107880003405 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1107880003406 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1107880003407 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1107880003408 conserved cys residue [active] 1107880003409 Myosin heavy chain [Cytoskeleton]; Region: COG5022 1107880003410 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1107880003411 active site 1107880003412 catalytic site [active] 1107880003413 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1107880003414 Helix-turn-helix domain; Region: HTH_38; pfam13936 1107880003415 Integrase core domain; Region: rve; pfam00665 1107880003416 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1107880003417 putative active site [active] 1107880003418 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1107880003419 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1107880003420 potential frameshift: common BLAST hit: gi|170017259|ref|YP_001728178.1| Type IC restriction subunit 1107880003421 CAAX protease self-immunity; Region: Abi; pfam02517 1107880003422 hypothetical protein; Validated; Region: PRK06769 1107880003423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880003424 active site 1107880003425 motif I; other site 1107880003426 motif II; other site 1107880003427 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 1107880003428 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1107880003429 Cadmium resistance transporter; Region: Cad; pfam03596 1107880003430 potential frameshift: common BLAST hit: gi|116618238|ref|YP_818609.1| cytidine deaminase 1107880003431 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1107880003432 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 1107880003433 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1107880003434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1107880003436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1107880003438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880003439 active site 1107880003440 phosphorylation site [posttranslational modification] 1107880003441 intermolecular recognition site; other site 1107880003442 dimerization interface [polypeptide binding]; other site 1107880003443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1107880003444 DNA binding residues [nucleotide binding] 1107880003445 dimerization interface [polypeptide binding]; other site 1107880003446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1107880003447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1107880003448 Histidine kinase; Region: HisKA_3; pfam07730 1107880003449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880003450 ATP binding site [chemical binding]; other site 1107880003451 Mg2+ binding site [ion binding]; other site 1107880003452 G-X-G motif; other site 1107880003453 MMPL family; Region: MMPL; pfam03176 1107880003454 MMPL family; Region: MMPL; pfam03176 1107880003455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1107880003456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880003457 Coenzyme A binding pocket [chemical binding]; other site 1107880003458 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1107880003459 FAD binding domain; Region: FAD_binding_4; pfam01565 1107880003460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003462 putative substrate translocation pore; other site 1107880003463 Helix-turn-helix domain; Region: HTH_18; pfam12833 1107880003464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880003465 acetoin reductases; Region: 23BDH; TIGR02415 1107880003466 NAD(P) binding site [chemical binding]; other site 1107880003467 active site 1107880003468 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1107880003469 allantoate amidohydrolase; Reviewed; Region: PRK09290 1107880003470 active site 1107880003471 metal binding site [ion binding]; metal-binding site 1107880003472 dimer interface [polypeptide binding]; other site 1107880003473 potential frameshift: common BLAST hit: gi|296110935|ref|YP_003621316.1| major facilitator family transporter 1107880003474 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1107880003475 ThiS interaction site; other site 1107880003476 putative active site [active] 1107880003477 tetramer interface [polypeptide binding]; other site 1107880003478 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 1107880003479 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 1107880003480 putative ATP binding site [chemical binding]; other site 1107880003481 putative substrate interface [chemical binding]; other site 1107880003482 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1107880003483 thiS-thiF/thiG interaction site; other site 1107880003484 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1107880003485 thiamine phosphate binding site [chemical binding]; other site 1107880003486 active site 1107880003487 pyrophosphate binding site [ion binding]; other site 1107880003488 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1107880003489 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1107880003490 active site 1107880003491 catalytic residue [active] 1107880003492 dimer interface [polypeptide binding]; other site 1107880003493 Prephenate dehydratase; Region: PDT; pfam00800 1107880003494 shikimate kinase; Reviewed; Region: aroK; PRK00131 1107880003495 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1107880003496 ADP binding site [chemical binding]; other site 1107880003497 magnesium binding site [ion binding]; other site 1107880003498 putative shikimate binding site; other site 1107880003499 Chorismate mutase type II; Region: CM_2; smart00830 1107880003500 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1107880003501 prephenate dehydrogenase; Validated; Region: PRK08507 1107880003502 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1107880003503 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1107880003504 hinge; other site 1107880003505 active site 1107880003506 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1107880003507 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1107880003508 Tetramer interface [polypeptide binding]; other site 1107880003509 active site 1107880003510 FMN-binding site [chemical binding]; other site 1107880003511 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1107880003512 active site 1107880003513 dimer interface [polypeptide binding]; other site 1107880003514 metal binding site [ion binding]; metal-binding site 1107880003515 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1107880003516 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1107880003517 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1107880003518 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1107880003519 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1107880003520 shikimate binding site; other site 1107880003521 NAD(P) binding site [chemical binding]; other site 1107880003522 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1107880003523 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1107880003524 TPP-binding site [chemical binding]; other site 1107880003525 dimer interface [polypeptide binding]; other site 1107880003526 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1107880003527 PYR/PP interface [polypeptide binding]; other site 1107880003528 dimer interface [polypeptide binding]; other site 1107880003529 TPP binding site [chemical binding]; other site 1107880003530 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1107880003531 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1107880003532 glutamine binding [chemical binding]; other site 1107880003533 catalytic triad [active] 1107880003534 anthranilate synthase component I; Provisional; Region: PRK13570 1107880003535 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1107880003536 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1107880003537 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1107880003538 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1107880003539 substrate binding site [chemical binding]; other site 1107880003540 active site 1107880003541 catalytic residues [active] 1107880003542 heterodimer interface [polypeptide binding]; other site 1107880003543 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1107880003544 active site 1107880003545 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1107880003546 active site 1107880003547 ribulose/triose binding site [chemical binding]; other site 1107880003548 phosphate binding site [ion binding]; other site 1107880003549 substrate (anthranilate) binding pocket [chemical binding]; other site 1107880003550 product (indole) binding pocket [chemical binding]; other site 1107880003551 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1107880003552 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1107880003553 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1107880003554 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1107880003555 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1107880003556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003557 catalytic residue [active] 1107880003558 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1107880003559 active site 1107880003560 catalytic residues [active] 1107880003561 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1107880003562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1107880003563 active site 1107880003564 DNA binding site [nucleotide binding] 1107880003565 Int/Topo IB signature motif; other site 1107880003566 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1107880003567 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1107880003568 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1107880003569 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1107880003570 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1107880003571 dimer interface [polypeptide binding]; other site 1107880003572 active site 1107880003573 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1107880003574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880003575 Walker A/P-loop; other site 1107880003576 ATP binding site [chemical binding]; other site 1107880003577 Q-loop/lid; other site 1107880003578 ABC transporter signature motif; other site 1107880003579 Walker B; other site 1107880003580 D-loop; other site 1107880003581 H-loop/switch region; other site 1107880003582 ABC transporter; Region: ABC_tran_2; pfam12848 1107880003583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880003584 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1107880003585 RNA methyltransferase, RsmE family; Region: TIGR00046 1107880003586 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1107880003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880003588 S-adenosylmethionine binding site [chemical binding]; other site 1107880003589 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1107880003590 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1107880003591 putative NAD(P) binding site [chemical binding]; other site 1107880003592 dimer interface [polypeptide binding]; other site 1107880003593 GTP-binding protein LepA; Provisional; Region: PRK05433 1107880003594 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1107880003595 G1 box; other site 1107880003596 putative GEF interaction site [polypeptide binding]; other site 1107880003597 GTP/Mg2+ binding site [chemical binding]; other site 1107880003598 Switch I region; other site 1107880003599 G2 box; other site 1107880003600 G3 box; other site 1107880003601 Switch II region; other site 1107880003602 G4 box; other site 1107880003603 G5 box; other site 1107880003604 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1107880003605 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1107880003606 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1107880003607 putative oxidoreductase; Provisional; Region: PRK10206 1107880003608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1107880003609 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1107880003610 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1107880003611 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1107880003612 motif 1; other site 1107880003613 dimer interface [polypeptide binding]; other site 1107880003614 active site 1107880003615 motif 2; other site 1107880003616 motif 3; other site 1107880003617 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1107880003618 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1107880003619 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1107880003620 hinge region; other site 1107880003621 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1107880003622 putative nucleotide binding site [chemical binding]; other site 1107880003623 uridine monophosphate binding site [chemical binding]; other site 1107880003624 homohexameric interface [polypeptide binding]; other site 1107880003625 elongation factor Ts; Provisional; Region: tsf; PRK09377 1107880003626 UBA/TS-N domain; Region: UBA; pfam00627 1107880003627 Elongation factor TS; Region: EF_TS; pfam00889 1107880003628 Elongation factor TS; Region: EF_TS; pfam00889 1107880003629 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1107880003630 rRNA interaction site [nucleotide binding]; other site 1107880003631 S8 interaction site; other site 1107880003632 putative laminin-1 binding site; other site 1107880003633 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1107880003634 GIY-YIG motif/motif A; other site 1107880003635 putative active site [active] 1107880003636 putative metal binding site [ion binding]; other site 1107880003637 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1107880003638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880003639 S-adenosylmethionine binding site [chemical binding]; other site 1107880003640 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1107880003641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1107880003642 putative acyl-acceptor binding pocket; other site 1107880003643 LexA repressor; Validated; Region: PRK00215 1107880003644 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1107880003645 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1107880003646 Catalytic site [active] 1107880003647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880003648 active site 1107880003649 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1107880003650 active site 1107880003651 dimer interface [polypeptide binding]; other site 1107880003652 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1107880003653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1107880003654 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1107880003655 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1107880003656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1107880003657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1107880003658 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1107880003659 IMP binding site; other site 1107880003660 dimer interface [polypeptide binding]; other site 1107880003661 interdomain contacts; other site 1107880003662 partial ornithine binding site; other site 1107880003663 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1107880003664 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1107880003665 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1107880003666 catalytic site [active] 1107880003667 subunit interface [polypeptide binding]; other site 1107880003668 dihydroorotase; Validated; Region: pyrC; PRK09357 1107880003669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1107880003670 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1107880003671 active site 1107880003672 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1107880003673 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1107880003674 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1107880003675 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1107880003676 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1107880003677 Catalytic site [active] 1107880003678 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1107880003679 Protein of unknown function (DUF964); Region: DUF964; cl01483 1107880003680 Transglycosylase; Region: Transgly; pfam00912 1107880003681 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1107880003682 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1107880003683 Arginine repressor [Transcription]; Region: ArgR; COG1438 1107880003684 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1107880003685 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1107880003686 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1107880003687 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1107880003688 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1107880003689 active site 1107880003690 HIGH motif; other site 1107880003691 KMSK motif region; other site 1107880003692 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1107880003693 tRNA binding surface [nucleotide binding]; other site 1107880003694 anticodon binding site; other site 1107880003695 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1107880003696 Flavoprotein; Region: Flavoprotein; pfam02441 1107880003697 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1107880003698 Tubby C 2; Region: Tub_2; cl02043 1107880003699 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1107880003700 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1107880003701 HicB family; Region: HicB; pfam05534 1107880003702 CsbD-like; Region: CsbD; pfam05532 1107880003703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880003704 S-adenosylmethionine binding site [chemical binding]; other site 1107880003705 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1107880003706 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1107880003707 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1107880003708 Walker A/P-loop; other site 1107880003709 ATP binding site [chemical binding]; other site 1107880003710 Q-loop/lid; other site 1107880003711 ABC transporter signature motif; other site 1107880003712 Walker B; other site 1107880003713 D-loop; other site 1107880003714 H-loop/switch region; other site 1107880003715 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1107880003716 HIT family signature motif; other site 1107880003717 catalytic residue [active] 1107880003718 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1107880003719 potential frameshift: common BLAST hit: gi|116618331|ref|YP_818702.1| major facilitator superfamily permease 1107880003720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1107880003721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003722 aminotransferase A; Validated; Region: PRK07683 1107880003723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880003724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003725 homodimer interface [polypeptide binding]; other site 1107880003726 catalytic residue [active] 1107880003727 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 1107880003728 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1107880003729 putative ligand binding site [chemical binding]; other site 1107880003730 putative NAD binding site [chemical binding]; other site 1107880003731 catalytic site [active] 1107880003732 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880003733 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880003734 Walker A/P-loop; other site 1107880003735 ATP binding site [chemical binding]; other site 1107880003736 Q-loop/lid; other site 1107880003737 ABC transporter signature motif; other site 1107880003738 Walker B; other site 1107880003739 D-loop; other site 1107880003740 H-loop/switch region; other site 1107880003741 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1107880003742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880003743 dimer interface [polypeptide binding]; other site 1107880003744 conserved gate region; other site 1107880003745 putative PBP binding loops; other site 1107880003746 ABC-ATPase subunit interface; other site 1107880003747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880003748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880003749 substrate binding pocket [chemical binding]; other site 1107880003750 membrane-bound complex binding site; other site 1107880003751 hinge residues; other site 1107880003752 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1107880003753 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1107880003754 homodimer interface [polypeptide binding]; other site 1107880003755 substrate-cofactor binding pocket; other site 1107880003756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003757 catalytic residue [active] 1107880003758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1107880003759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1107880003760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1107880003761 dimerization interface [polypeptide binding]; other site 1107880003762 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1107880003763 classical (c) SDRs; Region: SDR_c; cd05233 1107880003764 NAD(P) binding site [chemical binding]; other site 1107880003765 active site 1107880003766 QueT transporter; Region: QueT; pfam06177 1107880003767 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1107880003768 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1107880003769 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1107880003770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1107880003771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1107880003772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1107880003773 DNA binding residues [nucleotide binding] 1107880003774 DNA primase; Validated; Region: dnaG; PRK05667 1107880003775 CHC2 zinc finger; Region: zf-CHC2; cl17510 1107880003776 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1107880003777 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1107880003778 active site 1107880003779 metal binding site [ion binding]; metal-binding site 1107880003780 interdomain interaction site; other site 1107880003781 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1107880003782 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1107880003783 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 1107880003784 active site 1107880003785 phosphorylation site [posttranslational modification] 1107880003786 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1107880003787 active pocket/dimerization site; other site 1107880003788 active site 1107880003789 phosphorylation site [posttranslational modification] 1107880003790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1107880003791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880003792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1107880003793 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1107880003794 DNA protecting protein DprA; Region: dprA; TIGR00732 1107880003795 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1107880003796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880003797 Walker A/P-loop; other site 1107880003798 ATP binding site [chemical binding]; other site 1107880003799 Q-loop/lid; other site 1107880003800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880003801 ABC transporter signature motif; other site 1107880003802 Walker B; other site 1107880003803 D-loop; other site 1107880003804 ABC transporter; Region: ABC_tran_2; pfam12848 1107880003805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880003806 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1107880003807 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1107880003808 active site 1107880003809 FMN binding site [chemical binding]; other site 1107880003810 substrate binding site [chemical binding]; other site 1107880003811 catalytic residues [active] 1107880003812 homodimer interface [polypeptide binding]; other site 1107880003813 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1107880003814 propionate/acetate kinase; Provisional; Region: PRK12379 1107880003815 Bacterial SH3 domain; Region: SH3_3; pfam08239 1107880003816 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1107880003817 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1107880003818 active site 1107880003819 metal binding site [ion binding]; metal-binding site 1107880003820 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1107880003821 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1107880003822 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1107880003823 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1107880003824 RNA binding site [nucleotide binding]; other site 1107880003825 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1107880003826 Ligand Binding Site [chemical binding]; other site 1107880003827 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1107880003828 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1107880003829 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1107880003830 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1107880003831 dimer interface [polypeptide binding]; other site 1107880003832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003833 catalytic residue [active] 1107880003834 cystathionine beta-lyase; Provisional; Region: PRK07671 1107880003835 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1107880003836 homodimer interface [polypeptide binding]; other site 1107880003837 substrate-cofactor binding pocket; other site 1107880003838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880003839 catalytic residue [active] 1107880003840 serine O-acetyltransferase; Region: cysE; TIGR01172 1107880003841 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1107880003842 trimer interface [polypeptide binding]; other site 1107880003843 active site 1107880003844 substrate binding site [chemical binding]; other site 1107880003845 CoA binding site [chemical binding]; other site 1107880003846 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1107880003847 IHF dimer interface [polypeptide binding]; other site 1107880003848 IHF - DNA interface [nucleotide binding]; other site 1107880003849 GTP-binding protein Der; Reviewed; Region: PRK00093 1107880003850 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1107880003851 G1 box; other site 1107880003852 GTP/Mg2+ binding site [chemical binding]; other site 1107880003853 Switch I region; other site 1107880003854 G2 box; other site 1107880003855 Switch II region; other site 1107880003856 G3 box; other site 1107880003857 G4 box; other site 1107880003858 G5 box; other site 1107880003859 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1107880003860 G1 box; other site 1107880003861 GTP/Mg2+ binding site [chemical binding]; other site 1107880003862 Switch I region; other site 1107880003863 G2 box; other site 1107880003864 G3 box; other site 1107880003865 Switch II region; other site 1107880003866 G4 box; other site 1107880003867 G5 box; other site 1107880003868 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1107880003869 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1107880003870 RNA binding site [nucleotide binding]; other site 1107880003871 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1107880003872 RNA binding site [nucleotide binding]; other site 1107880003873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1107880003874 RNA binding site [nucleotide binding]; other site 1107880003875 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1107880003876 RNA binding site [nucleotide binding]; other site 1107880003877 cytidylate kinase; Provisional; Region: cmk; PRK00023 1107880003878 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1107880003879 CMP-binding site; other site 1107880003880 The sites determining sugar specificity; other site 1107880003881 Predicted membrane protein [Function unknown]; Region: COG3601 1107880003882 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1107880003883 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1107880003884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1107880003885 RNA binding surface [nucleotide binding]; other site 1107880003886 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1107880003887 active site 1107880003888 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1107880003889 ScpA/B protein; Region: ScpA_ScpB; cl00598 1107880003890 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1107880003891 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1107880003892 active site 1107880003893 Int/Topo IB signature motif; other site 1107880003894 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1107880003895 S1 domain; Region: S1_2; pfam13509 1107880003896 Yqey-like protein; Region: YqeY; pfam09424 1107880003897 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1107880003898 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1107880003899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880003900 putative substrate translocation pore; other site 1107880003901 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1107880003902 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1107880003903 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1107880003904 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1107880003905 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880003906 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1107880003907 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880003908 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1107880003909 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1107880003910 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1107880003911 dimer interface [polypeptide binding]; other site 1107880003912 anticodon binding site; other site 1107880003913 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1107880003914 motif 1; other site 1107880003915 dimer interface [polypeptide binding]; other site 1107880003916 active site 1107880003917 motif 2; other site 1107880003918 GAD domain; Region: GAD; pfam02938 1107880003919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1107880003920 active site 1107880003921 motif 3; other site 1107880003922 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1107880003923 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1107880003924 dimer interface [polypeptide binding]; other site 1107880003925 motif 1; other site 1107880003926 active site 1107880003927 motif 2; other site 1107880003928 motif 3; other site 1107880003929 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1107880003930 anticodon binding site; other site 1107880003931 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1107880003932 active site 1107880003933 catalytic residues [active] 1107880003934 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1107880003935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1107880003937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880003938 galactokinase; Provisional; Region: PRK05322 1107880003939 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1107880003940 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1107880003941 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1107880003942 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1107880003943 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880003944 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880003945 active site 1107880003946 catalytic tetrad [active] 1107880003947 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1107880003948 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1107880003949 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1107880003950 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1107880003951 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1107880003952 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1107880003953 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1107880003954 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1107880003955 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1107880003956 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1107880003957 NAD binding site [chemical binding]; other site 1107880003958 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1107880003959 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1107880003960 homodimer interface [polypeptide binding]; other site 1107880003961 substrate-cofactor binding pocket; other site 1107880003962 catalytic residue [active] 1107880003963 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1107880003964 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1107880003965 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1107880003966 active site 1107880003967 metal binding site [ion binding]; metal-binding site 1107880003968 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1107880003969 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1107880003970 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1107880003971 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1107880003972 active site 1107880003973 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1107880003974 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1107880003975 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1107880003976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1107880003977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880003978 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1107880003979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880003980 Coenzyme A binding pocket [chemical binding]; other site 1107880003981 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1107880003982 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1107880003983 Predicted integral membrane protein [Function unknown]; Region: COG5617 1107880003984 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1107880003985 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1107880003986 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1107880003987 G1 box; other site 1107880003988 putative GEF interaction site [polypeptide binding]; other site 1107880003989 GTP/Mg2+ binding site [chemical binding]; other site 1107880003990 Switch I region; other site 1107880003991 G2 box; other site 1107880003992 G3 box; other site 1107880003993 Switch II region; other site 1107880003994 G4 box; other site 1107880003995 G5 box; other site 1107880003996 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1107880003997 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1107880003998 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1107880003999 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1107880004000 active site 1107880004001 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1107880004002 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1107880004003 active site 1107880004004 catalytic residues [active] 1107880004005 metal binding site [ion binding]; metal-binding site 1107880004006 chaperone protein DnaJ; Provisional; Region: PRK14299 1107880004007 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1107880004008 HSP70 interaction site [polypeptide binding]; other site 1107880004009 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1107880004010 substrate binding site [polypeptide binding]; other site 1107880004011 dimer interface [polypeptide binding]; other site 1107880004012 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1107880004013 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1107880004014 nucleotide binding site [chemical binding]; other site 1107880004015 NEF interaction site [polypeptide binding]; other site 1107880004016 SBD interface [polypeptide binding]; other site 1107880004017 GrpE; Region: GrpE; pfam01025 1107880004018 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1107880004019 dimer interface [polypeptide binding]; other site 1107880004020 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1107880004021 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1107880004022 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1107880004023 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1107880004024 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1107880004025 active site 1107880004026 Riboflavin kinase; Region: Flavokinase; smart00904 1107880004027 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1107880004028 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1107880004029 RNA binding site [nucleotide binding]; other site 1107880004030 active site 1107880004031 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1107880004032 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1107880004033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880004034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880004035 homodimer interface [polypeptide binding]; other site 1107880004036 catalytic residue [active] 1107880004037 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1107880004038 translation initiation factor IF-2; Region: IF-2; TIGR00487 1107880004039 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1107880004040 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1107880004041 G1 box; other site 1107880004042 putative GEF interaction site [polypeptide binding]; other site 1107880004043 GTP/Mg2+ binding site [chemical binding]; other site 1107880004044 Switch I region; other site 1107880004045 G2 box; other site 1107880004046 G3 box; other site 1107880004047 Switch II region; other site 1107880004048 G4 box; other site 1107880004049 G5 box; other site 1107880004050 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1107880004051 Translation-initiation factor 2; Region: IF-2; pfam11987 1107880004052 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1107880004053 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1107880004054 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1107880004055 putative RNA binding cleft [nucleotide binding]; other site 1107880004056 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1107880004057 NusA N-terminal domain; Region: NusA_N; pfam08529 1107880004058 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1107880004059 RNA binding site [nucleotide binding]; other site 1107880004060 homodimer interface [polypeptide binding]; other site 1107880004061 NusA-like KH domain; Region: KH_5; pfam13184 1107880004062 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1107880004063 G-X-X-G motif; other site 1107880004064 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1107880004065 Sm and related proteins; Region: Sm_like; cl00259 1107880004066 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1107880004067 putative oligomer interface [polypeptide binding]; other site 1107880004068 putative RNA binding site [nucleotide binding]; other site 1107880004069 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1107880004070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1107880004071 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1107880004072 DHH family; Region: DHH; pfam01368 1107880004073 DHHA2 domain; Region: DHHA2; pfam02833 1107880004074 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1107880004075 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1107880004076 CAP-like domain; other site 1107880004077 active site 1107880004078 primary dimer interface [polypeptide binding]; other site 1107880004079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1107880004080 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1107880004081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880004082 Mg2+ binding site [ion binding]; other site 1107880004083 G-X-G motif; other site 1107880004084 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1107880004085 anchoring element; other site 1107880004086 dimer interface [polypeptide binding]; other site 1107880004087 ATP binding site [chemical binding]; other site 1107880004088 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1107880004089 active site 1107880004090 putative metal-binding site [ion binding]; other site 1107880004091 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1107880004092 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1107880004093 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1107880004094 putative active site [active] 1107880004095 dimerization interface [polypeptide binding]; other site 1107880004096 putative tRNAtyr binding site [nucleotide binding]; other site 1107880004097 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1107880004098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880004099 Zn2+ binding site [ion binding]; other site 1107880004100 Mg2+ binding site [ion binding]; other site 1107880004101 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1107880004102 synthetase active site [active] 1107880004103 NTP binding site [chemical binding]; other site 1107880004104 metal binding site [ion binding]; metal-binding site 1107880004105 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1107880004106 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1107880004107 drug efflux system protein MdtG; Provisional; Region: PRK09874 1107880004108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880004109 putative substrate translocation pore; other site 1107880004110 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1107880004111 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1107880004112 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1107880004113 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1107880004114 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1107880004115 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1107880004116 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1107880004117 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1107880004118 catalytic site [active] 1107880004119 subunit interface [polypeptide binding]; other site 1107880004120 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1107880004121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880004122 active site 1107880004123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1107880004124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1107880004125 RNA binding surface [nucleotide binding]; other site 1107880004126 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1107880004127 active site 1107880004128 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1107880004129 RNA/DNA hybrid binding site [nucleotide binding]; other site 1107880004130 active site 1107880004131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1107880004132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880004133 Coenzyme A binding pocket [chemical binding]; other site 1107880004134 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1107880004135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880004136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880004137 homodimer interface [polypeptide binding]; other site 1107880004138 catalytic residue [active] 1107880004139 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1107880004140 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1107880004141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1107880004142 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1107880004143 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1107880004144 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1107880004145 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1107880004146 putative dimer interface [polypeptide binding]; other site 1107880004147 putative anticodon binding site; other site 1107880004148 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1107880004149 homodimer interface [polypeptide binding]; other site 1107880004150 motif 1; other site 1107880004151 motif 2; other site 1107880004152 active site 1107880004153 motif 3; other site 1107880004154 aspartate aminotransferase; Provisional; Region: PRK05764 1107880004155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880004156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880004157 homodimer interface [polypeptide binding]; other site 1107880004158 catalytic residue [active] 1107880004159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1107880004160 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1107880004161 active site 1107880004162 catalytic site [active] 1107880004163 substrate binding site [chemical binding]; other site 1107880004164 mevalonate kinase; Region: mevalon_kin; TIGR00549 1107880004165 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1107880004166 diphosphomevalonate decarboxylase; Region: PLN02407 1107880004167 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1107880004168 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1107880004169 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1107880004170 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1107880004171 homotetramer interface [polypeptide binding]; other site 1107880004172 FMN binding site [chemical binding]; other site 1107880004173 homodimer contacts [polypeptide binding]; other site 1107880004174 putative active site [active] 1107880004175 putative substrate binding site [chemical binding]; other site 1107880004176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880004177 active site 1107880004178 adenylosuccinate lyase; Provisional; Region: PRK07492 1107880004179 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1107880004180 tetramer interface [polypeptide binding]; other site 1107880004181 active site 1107880004182 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1107880004183 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1107880004184 amphipathic channel; other site 1107880004185 Asn-Pro-Ala signature motifs; other site 1107880004186 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1107880004187 Predicted membrane protein [Function unknown]; Region: COG2246 1107880004188 GtrA-like protein; Region: GtrA; pfam04138 1107880004189 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1107880004190 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1107880004191 Probable Catalytic site; other site 1107880004192 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1107880004193 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1107880004194 Sulfatase; Region: Sulfatase; cl17466 1107880004195 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1107880004196 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1107880004197 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1107880004198 Ligand binding site; other site 1107880004199 Putative Catalytic site; other site 1107880004200 DXD motif; other site 1107880004201 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1107880004202 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1107880004203 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1107880004204 Ligand binding site; other site 1107880004205 Putative Catalytic site; other site 1107880004206 DXD motif; other site 1107880004207 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1107880004208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1107880004209 UDP-galactopyranose mutase; Region: GLF; pfam03275 1107880004210 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1107880004211 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1107880004212 Chain length determinant protein; Region: Wzz; cl15801 1107880004213 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1107880004214 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1107880004215 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1107880004216 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1107880004217 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1107880004218 substrate binding [chemical binding]; other site 1107880004219 active site 1107880004220 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1107880004221 active site 1107880004222 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1107880004223 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1107880004224 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 1107880004225 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1107880004226 active site 1107880004227 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1107880004228 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1107880004229 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1107880004230 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1107880004231 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1107880004232 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1107880004233 NADP binding site [chemical binding]; other site 1107880004234 active site 1107880004235 putative substrate binding site [chemical binding]; other site 1107880004236 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1107880004237 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1107880004238 NAD binding site [chemical binding]; other site 1107880004239 substrate binding site [chemical binding]; other site 1107880004240 homodimer interface [polypeptide binding]; other site 1107880004241 active site 1107880004242 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1107880004243 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1107880004244 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1107880004245 substrate binding site; other site 1107880004246 tetramer interface; other site 1107880004247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1107880004248 active site 1107880004249 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1107880004250 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1107880004251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880004252 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1107880004253 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1107880004254 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1107880004255 active site 1107880004256 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1107880004257 active site 1107880004258 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1107880004259 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1107880004260 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1107880004261 active site 1107880004262 nucleotide binding site [chemical binding]; other site 1107880004263 HIGH motif; other site 1107880004264 KMSKS motif; other site 1107880004265 LicD family; Region: LicD; pfam04991 1107880004266 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1107880004267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1107880004268 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1107880004269 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1107880004270 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1107880004271 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1107880004272 Chain length determinant protein; Region: Wzz; cl15801 1107880004273 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1107880004274 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1107880004275 active site 1107880004276 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1107880004277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880004278 active site 1107880004279 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1107880004280 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1107880004281 23S rRNA binding site [nucleotide binding]; other site 1107880004282 L21 binding site [polypeptide binding]; other site 1107880004283 L13 binding site [polypeptide binding]; other site 1107880004284 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1107880004285 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1107880004286 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1107880004287 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1107880004288 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1107880004289 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1107880004290 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1107880004291 CutC family; Region: CutC; cl01218 1107880004292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1107880004293 NAD(P) binding site [chemical binding]; other site 1107880004294 active site 1107880004295 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1107880004296 peroxiredoxin; Region: AhpC; TIGR03137 1107880004297 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1107880004298 dimer interface [polypeptide binding]; other site 1107880004299 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1107880004300 catalytic triad [active] 1107880004301 peroxidatic and resolving cysteines [active] 1107880004302 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1107880004303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880004304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880004305 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1107880004306 catalytic residue [active] 1107880004307 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1107880004308 catalytic residues [active] 1107880004309 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1107880004310 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1107880004311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004312 S-adenosylmethionine binding site [chemical binding]; other site 1107880004313 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1107880004314 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1107880004315 dimerization interface [polypeptide binding]; other site 1107880004316 active site 1107880004317 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1107880004318 putative phosphoketolase; Provisional; Region: PRK05261 1107880004319 XFP N-terminal domain; Region: XFP_N; pfam09364 1107880004320 XFP C-terminal domain; Region: XFP_C; pfam09363 1107880004321 ornithine carbamoyltransferase; Validated; Region: PRK02102 1107880004322 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1107880004323 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1107880004324 argininosuccinate lyase; Provisional; Region: PRK00855 1107880004325 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1107880004326 active sites [active] 1107880004327 tetramer interface [polypeptide binding]; other site 1107880004328 argininosuccinate synthase; Provisional; Region: PRK13820 1107880004329 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1107880004330 ANP binding site [chemical binding]; other site 1107880004331 Substrate Binding Site II [chemical binding]; other site 1107880004332 Substrate Binding Site I [chemical binding]; other site 1107880004333 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1107880004334 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1107880004335 GDP-binding site [chemical binding]; other site 1107880004336 ACT binding site; other site 1107880004337 IMP binding site; other site 1107880004338 hypothetical protein; Validated; Region: PRK00110 1107880004339 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1107880004340 tetramer interfaces [polypeptide binding]; other site 1107880004341 binuclear metal-binding site [ion binding]; other site 1107880004342 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1107880004343 putative ligand binding site [chemical binding]; other site 1107880004344 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1107880004345 putative NAD binding site [chemical binding]; other site 1107880004346 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1107880004347 L-serine binding site [chemical binding]; other site 1107880004348 ACT domain interface; other site 1107880004349 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1107880004350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1107880004351 catalytic residue [active] 1107880004352 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1107880004353 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1107880004354 ligand binding site [chemical binding]; other site 1107880004355 active site 1107880004356 UGI interface [polypeptide binding]; other site 1107880004357 catalytic site [active] 1107880004358 Tubby C 2; Region: Tub_2; cl02043 1107880004359 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1107880004360 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1107880004361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1107880004362 Domain of unknown function (DUF368); Region: DUF368; cl00893 1107880004363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880004364 active site 1107880004365 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1107880004366 DHH family; Region: DHH; pfam01368 1107880004367 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1107880004368 ribonuclease Z; Region: RNase_Z; TIGR02651 1107880004369 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1107880004370 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1107880004371 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1107880004372 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1107880004373 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1107880004374 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1107880004375 RimM N-terminal domain; Region: RimM; pfam01782 1107880004376 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1107880004377 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1107880004378 DNA binding site [nucleotide binding] 1107880004379 active site 1107880004380 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1107880004381 Part of AAA domain; Region: AAA_19; pfam13245 1107880004382 Family description; Region: UvrD_C_2; pfam13538 1107880004383 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1107880004384 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1107880004385 Predicted esterase [General function prediction only]; Region: COG0627 1107880004386 S-formylglutathione hydrolase; Region: PLN02442 1107880004387 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1107880004388 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1107880004389 HeH/LEM domain; Region: HeH; pfam12949 1107880004390 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1107880004391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1107880004392 active site 1107880004393 HIGH motif; other site 1107880004394 nucleotide binding site [chemical binding]; other site 1107880004395 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1107880004396 active site 1107880004397 KMSKS motif; other site 1107880004398 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1107880004399 tRNA binding surface [nucleotide binding]; other site 1107880004400 anticodon binding site; other site 1107880004401 DivIVA domain; Region: DivI1A_domain; TIGR03544 1107880004402 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1107880004403 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1107880004404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1107880004405 RNA binding surface [nucleotide binding]; other site 1107880004406 YGGT family; Region: YGGT; pfam02325 1107880004407 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1107880004408 cell division protein FtsZ; Validated; Region: PRK09330 1107880004409 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1107880004410 nucleotide binding site [chemical binding]; other site 1107880004411 SulA interaction site; other site 1107880004412 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1107880004413 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1107880004414 nucleotide binding site [chemical binding]; other site 1107880004415 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1107880004416 Cell division protein FtsA; Region: FtsA; pfam14450 1107880004417 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1107880004418 Cell division protein FtsQ; Region: FtsQ; pfam03799 1107880004419 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1107880004420 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1107880004421 active site 1107880004422 homodimer interface [polypeptide binding]; other site 1107880004423 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1107880004424 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880004425 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1107880004426 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1107880004427 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1107880004428 Mg++ binding site [ion binding]; other site 1107880004429 putative catalytic motif [active] 1107880004430 putative substrate binding site [chemical binding]; other site 1107880004431 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1107880004432 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1107880004433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1107880004434 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1107880004435 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1107880004436 Cell division protein FtsL; Region: FtsL; cl11433 1107880004437 MraW methylase family; Region: Methyltransf_5; pfam01795 1107880004438 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1107880004439 cell division protein MraZ; Reviewed; Region: PRK00326 1107880004440 MraZ protein; Region: MraZ; pfam02381 1107880004441 MraZ protein; Region: MraZ; pfam02381 1107880004442 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1107880004443 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1107880004444 DAK2 domain; Region: Dak2; pfam02734 1107880004445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1107880004446 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1107880004447 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880004448 catalytic residues [active] 1107880004449 Thiamine pyrophosphokinase; Region: TPK; cd07995 1107880004450 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1107880004451 active site 1107880004452 dimerization interface [polypeptide binding]; other site 1107880004453 thiamine binding site [chemical binding]; other site 1107880004454 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1107880004455 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1107880004456 substrate binding site [chemical binding]; other site 1107880004457 hexamer interface [polypeptide binding]; other site 1107880004458 metal binding site [ion binding]; metal-binding site 1107880004459 GTPase RsgA; Reviewed; Region: PRK00098 1107880004460 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1107880004461 RNA binding site [nucleotide binding]; other site 1107880004462 homodimer interface [polypeptide binding]; other site 1107880004463 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1107880004464 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1107880004465 GTP/Mg2+ binding site [chemical binding]; other site 1107880004466 G4 box; other site 1107880004467 G5 box; other site 1107880004468 G1 box; other site 1107880004469 Switch I region; other site 1107880004470 G2 box; other site 1107880004471 G3 box; other site 1107880004472 Switch II region; other site 1107880004473 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1107880004474 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1107880004475 active site 1107880004476 ATP binding site [chemical binding]; other site 1107880004477 substrate binding site [chemical binding]; other site 1107880004478 activation loop (A-loop); other site 1107880004479 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1107880004480 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1107880004481 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1107880004482 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1107880004483 active site 1107880004484 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1107880004485 NusB family; Region: NusB; pfam01029 1107880004486 putative RNA binding site [nucleotide binding]; other site 1107880004487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004488 S-adenosylmethionine binding site [chemical binding]; other site 1107880004489 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1107880004490 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1107880004491 putative active site [active] 1107880004492 substrate binding site [chemical binding]; other site 1107880004493 putative cosubstrate binding site; other site 1107880004494 catalytic site [active] 1107880004495 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1107880004496 substrate binding site [chemical binding]; other site 1107880004497 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1107880004498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880004499 ATP binding site [chemical binding]; other site 1107880004500 putative Mg++ binding site [ion binding]; other site 1107880004501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880004502 ATP-binding site [chemical binding]; other site 1107880004503 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1107880004504 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1107880004505 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1107880004506 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1107880004507 active site 1107880004508 nucleotide binding site [chemical binding]; other site 1107880004509 HIGH motif; other site 1107880004510 KMSKS motif; other site 1107880004511 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1107880004512 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1107880004513 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1107880004514 SelR domain; Region: SelR; pfam01641 1107880004515 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1107880004516 G1 box; other site 1107880004517 GTP/Mg2+ binding site [chemical binding]; other site 1107880004518 Switch I region; other site 1107880004519 G2 box; other site 1107880004520 G3 box; other site 1107880004521 Switch II region; other site 1107880004522 G4 box; other site 1107880004523 G5 box; other site 1107880004524 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1107880004525 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1107880004526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880004527 Walker A motif; other site 1107880004528 ATP binding site [chemical binding]; other site 1107880004529 Walker B motif; other site 1107880004530 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1107880004531 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1107880004532 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1107880004533 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1107880004534 Int/Topo IB signature motif; other site 1107880004535 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1107880004536 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1107880004537 potential frameshift: common BLAST hit: gi|28377765|ref|NP_784657.1| site-specific DNA-methyltransferase (adenine-specific), HsdM 1107880004538 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1107880004539 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1107880004540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880004541 ATP binding site [chemical binding]; other site 1107880004542 putative Mg++ binding site [ion binding]; other site 1107880004543 trigger factor; Provisional; Region: tig; PRK01490 1107880004544 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1107880004545 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1107880004546 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1107880004547 dipeptidase PepV; Reviewed; Region: PRK07318 1107880004548 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1107880004549 active site 1107880004550 metal binding site [ion binding]; metal-binding site 1107880004551 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1107880004552 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1107880004553 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1107880004554 putative substrate binding site [chemical binding]; other site 1107880004555 putative ATP binding site [chemical binding]; other site 1107880004556 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1107880004557 active site 1107880004558 putative catalytic site [active] 1107880004559 DNA binding site [nucleotide binding] 1107880004560 putative phosphate binding site [ion binding]; other site 1107880004561 metal binding site A [ion binding]; metal-binding site 1107880004562 AP binding site [nucleotide binding]; other site 1107880004563 metal binding site B [ion binding]; metal-binding site 1107880004564 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1107880004565 active site 1107880004566 catalytic site [active] 1107880004567 substrate binding site [chemical binding]; other site 1107880004568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880004569 Coenzyme A binding pocket [chemical binding]; other site 1107880004570 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1107880004571 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1107880004572 active site 1107880004573 catalytic site [active] 1107880004574 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1107880004575 active site 1107880004576 catalytic site [active] 1107880004577 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1107880004578 Cna protein B-type domain; Region: Cna_B; pfam05738 1107880004579 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1107880004580 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1107880004581 metal ion-dependent adhesion site (MIDAS); other site 1107880004582 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1107880004583 domain interaction interfaces [polypeptide binding]; other site 1107880004584 Cna protein B-type domain; Region: Cna_B; pfam05738 1107880004585 Cna protein B-type domain; Region: Cna_B; pfam05738 1107880004586 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1107880004587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1107880004588 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1107880004589 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1107880004590 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1107880004591 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1107880004592 effector binding site; other site 1107880004593 active site 1107880004594 Zn binding site [ion binding]; other site 1107880004595 glycine loop; other site 1107880004596 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1107880004597 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1107880004598 active site 1107880004599 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1107880004600 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1107880004601 homodimer interface [polypeptide binding]; other site 1107880004602 NAD binding pocket [chemical binding]; other site 1107880004603 ATP binding pocket [chemical binding]; other site 1107880004604 Mg binding site [ion binding]; other site 1107880004605 active-site loop [active] 1107880004606 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1107880004607 Cobalt transport protein; Region: CbiQ; cl00463 1107880004608 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880004609 Walker A/P-loop; other site 1107880004610 ATP binding site [chemical binding]; other site 1107880004611 ABC transporter; Region: ABC_tran; pfam00005 1107880004612 Q-loop/lid; other site 1107880004613 ABC transporter signature motif; other site 1107880004614 Walker B; other site 1107880004615 D-loop; other site 1107880004616 H-loop/switch region; other site 1107880004617 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880004618 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1107880004619 Walker A/P-loop; other site 1107880004620 ATP binding site [chemical binding]; other site 1107880004621 Q-loop/lid; other site 1107880004622 ABC transporter signature motif; other site 1107880004623 Walker B; other site 1107880004624 D-loop; other site 1107880004625 H-loop/switch region; other site 1107880004626 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1107880004627 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1107880004628 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1107880004629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880004631 homodimer interface [polypeptide binding]; other site 1107880004632 catalytic residue [active] 1107880004633 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1107880004634 metal binding site [ion binding]; metal-binding site 1107880004635 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1107880004636 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1107880004637 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1107880004638 substrate binding site [chemical binding]; other site 1107880004639 glutamase interaction surface [polypeptide binding]; other site 1107880004640 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1107880004641 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1107880004642 catalytic residues [active] 1107880004643 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1107880004644 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1107880004645 putative active site [active] 1107880004646 oxyanion strand; other site 1107880004647 catalytic triad [active] 1107880004648 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1107880004649 putative active site pocket [active] 1107880004650 4-fold oligomerization interface [polypeptide binding]; other site 1107880004651 metal binding residues [ion binding]; metal-binding site 1107880004652 3-fold/trimer interface [polypeptide binding]; other site 1107880004653 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1107880004654 histidinol dehydrogenase; Region: hisD; TIGR00069 1107880004655 NAD binding site [chemical binding]; other site 1107880004656 dimerization interface [polypeptide binding]; other site 1107880004657 product binding site; other site 1107880004658 substrate binding site [chemical binding]; other site 1107880004659 zinc binding site [ion binding]; other site 1107880004660 catalytic residues [active] 1107880004661 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1107880004662 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1107880004663 dimer interface [polypeptide binding]; other site 1107880004664 motif 1; other site 1107880004665 active site 1107880004666 motif 2; other site 1107880004667 motif 3; other site 1107880004668 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1107880004669 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1107880004670 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1107880004671 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1107880004672 metal binding site [ion binding]; metal-binding site 1107880004673 active site 1107880004674 I-site; other site 1107880004675 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1107880004676 histidinol-phosphatase; Reviewed; Region: PRK08123 1107880004677 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1107880004678 active site 1107880004679 dimer interface [polypeptide binding]; other site 1107880004680 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1107880004681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880004682 active site 1107880004683 motif I; other site 1107880004684 motif II; other site 1107880004685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880004686 signal recognition particle protein; Provisional; Region: PRK10867 1107880004687 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1107880004688 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1107880004689 P loop; other site 1107880004690 GTP binding site [chemical binding]; other site 1107880004691 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1107880004692 putative DNA-binding protein; Validated; Region: PRK00118 1107880004693 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1107880004694 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1107880004695 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1107880004696 P loop; other site 1107880004697 GTP binding site [chemical binding]; other site 1107880004698 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1107880004699 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1107880004700 Walker A/P-loop; other site 1107880004701 ATP binding site [chemical binding]; other site 1107880004702 Q-loop/lid; other site 1107880004703 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1107880004704 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1107880004705 ABC transporter signature motif; other site 1107880004706 Walker B; other site 1107880004707 D-loop; other site 1107880004708 H-loop/switch region; other site 1107880004709 ribonuclease III; Reviewed; Region: rnc; PRK00102 1107880004710 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1107880004711 dimerization interface [polypeptide binding]; other site 1107880004712 active site 1107880004713 metal binding site [ion binding]; metal-binding site 1107880004714 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1107880004715 dsRNA binding site [nucleotide binding]; other site 1107880004716 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1107880004717 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1107880004718 active site 1107880004719 substrate binding site [chemical binding]; other site 1107880004720 metal binding site [ion binding]; metal-binding site 1107880004721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1107880004722 YbbR-like protein; Region: YbbR; pfam07949 1107880004723 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1107880004724 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1107880004725 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1107880004726 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1107880004727 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1107880004728 FAD binding domain; Region: FAD_binding_4; pfam01565 1107880004729 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1107880004730 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1107880004731 active site 1107880004732 multimer interface [polypeptide binding]; other site 1107880004733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1107880004734 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1107880004735 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1107880004736 CsbD-like; Region: CsbD; cl17424 1107880004737 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1107880004738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880004739 ATP binding site [chemical binding]; other site 1107880004740 Mg2+ binding site [ion binding]; other site 1107880004741 G-X-G motif; other site 1107880004742 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1107880004743 ATP binding site [chemical binding]; other site 1107880004744 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1107880004745 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1107880004746 MutS domain I; Region: MutS_I; pfam01624 1107880004747 MutS domain II; Region: MutS_II; pfam05188 1107880004748 MutS domain III; Region: MutS_III; pfam05192 1107880004749 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1107880004750 Walker A/P-loop; other site 1107880004751 ATP binding site [chemical binding]; other site 1107880004752 Q-loop/lid; other site 1107880004753 ABC transporter signature motif; other site 1107880004754 Walker B; other site 1107880004755 D-loop; other site 1107880004756 H-loop/switch region; other site 1107880004757 TRAM domain; Region: TRAM; cl01282 1107880004758 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1107880004759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004760 S-adenosylmethionine binding site [chemical binding]; other site 1107880004761 putative lipid kinase; Reviewed; Region: PRK13055 1107880004762 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1107880004763 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1107880004764 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1107880004765 GatB domain; Region: GatB_Yqey; smart00845 1107880004766 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1107880004767 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1107880004768 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1107880004769 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1107880004770 16S/18S rRNA binding site [nucleotide binding]; other site 1107880004771 S13e-L30e interaction site [polypeptide binding]; other site 1107880004772 25S rRNA binding site [nucleotide binding]; other site 1107880004773 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1107880004774 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1107880004775 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1107880004776 ATP binding site [chemical binding]; other site 1107880004777 Mg++ binding site [ion binding]; other site 1107880004778 motif III; other site 1107880004779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880004780 nucleotide binding region [chemical binding]; other site 1107880004781 ATP-binding site [chemical binding]; other site 1107880004782 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1107880004783 DHH family; Region: DHH; pfam01368 1107880004784 DHHA1 domain; Region: DHHA1; pfam02272 1107880004785 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1107880004786 active site 1107880004787 DNA polymerase IV; Validated; Region: PRK02406 1107880004788 DNA binding site [nucleotide binding] 1107880004789 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1107880004790 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1107880004791 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1107880004792 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1107880004793 Competence protein; Region: Competence; pfam03772 1107880004794 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1107880004795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1107880004796 SLBB domain; Region: SLBB; pfam10531 1107880004797 comEA protein; Region: comE; TIGR01259 1107880004798 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1107880004799 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1107880004800 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1107880004801 protein binding site [polypeptide binding]; other site 1107880004802 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1107880004803 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1107880004804 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1107880004805 active site 1107880004806 (T/H)XGH motif; other site 1107880004807 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1107880004808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004809 S-adenosylmethionine binding site [chemical binding]; other site 1107880004810 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1107880004811 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1107880004812 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1107880004813 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1107880004814 oligomer interface [polypeptide binding]; other site 1107880004815 active site 1107880004816 metal binding site [ion binding]; metal-binding site 1107880004817 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880004818 catalytic core [active] 1107880004819 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880004820 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1107880004821 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1107880004822 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1107880004823 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1107880004824 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1107880004825 Walker A/P-loop; other site 1107880004826 ATP binding site [chemical binding]; other site 1107880004827 Q-loop/lid; other site 1107880004828 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1107880004829 ABC transporter signature motif; other site 1107880004830 Walker B; other site 1107880004831 D-loop; other site 1107880004832 H-loop/switch region; other site 1107880004833 Arginine repressor [Transcription]; Region: ArgR; COG1438 1107880004834 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1107880004835 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1107880004836 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1107880004837 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1107880004838 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1107880004839 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1107880004840 substrate binding pocket [chemical binding]; other site 1107880004841 chain length determination region; other site 1107880004842 catalytic residues [active] 1107880004843 aspartate-rich region 1; other site 1107880004844 substrate-Mg2+ binding site; other site 1107880004845 active site lid residues [active] 1107880004846 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1107880004847 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1107880004848 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1107880004849 generic binding surface II; other site 1107880004850 generic binding surface I; other site 1107880004851 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1107880004852 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1107880004853 Substrate binding site; other site 1107880004854 Mg++ binding site; other site 1107880004855 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1107880004856 active site 1107880004857 substrate binding site [chemical binding]; other site 1107880004858 CoA binding site [chemical binding]; other site 1107880004859 pur operon repressor; Provisional; Region: PRK09213 1107880004860 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1107880004861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880004862 active site 1107880004863 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1107880004864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1107880004865 ABC-ATPase subunit interface; other site 1107880004866 dimer interface [polypeptide binding]; other site 1107880004867 putative PBP binding regions; other site 1107880004868 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1107880004869 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1107880004870 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1107880004871 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1107880004872 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1107880004873 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1107880004874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004875 S-adenosylmethionine binding site [chemical binding]; other site 1107880004876 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1107880004877 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1107880004878 putative active site [active] 1107880004879 putative metal binding site [ion binding]; other site 1107880004880 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1107880004881 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1107880004882 active site 1107880004883 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1107880004884 putative RNA binding site [nucleotide binding]; other site 1107880004885 Asp23 family; Region: Asp23; pfam03780 1107880004886 elongation factor P; Validated; Region: PRK00529 1107880004887 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1107880004888 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1107880004889 RNA binding site [nucleotide binding]; other site 1107880004890 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1107880004891 RNA binding site [nucleotide binding]; other site 1107880004892 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1107880004893 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1107880004894 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1107880004895 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1107880004896 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1107880004897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1107880004898 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1107880004899 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1107880004900 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 1107880004901 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 1107880004902 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1107880004903 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1107880004904 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1107880004905 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1107880004906 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1107880004907 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1107880004908 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1107880004909 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1107880004910 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1107880004911 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1107880004912 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1107880004913 active site 1107880004914 catalytic site [active] 1107880004915 metal binding site [ion binding]; metal-binding site 1107880004916 dimer interface [polypeptide binding]; other site 1107880004917 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1107880004918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1107880004919 active site residue [active] 1107880004920 adaptor protein; Provisional; Region: PRK02315 1107880004921 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1107880004922 ArsC family; Region: ArsC; pfam03960 1107880004923 putative catalytic residues [active] 1107880004924 thiol/disulfide switch; other site 1107880004925 general stress protein 13; Validated; Region: PRK08059 1107880004926 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1107880004927 RNA binding site [nucleotide binding]; other site 1107880004928 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1107880004929 active site 1107880004930 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1107880004931 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1107880004932 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1107880004933 catalytic site [active] 1107880004934 G-X2-G-X-G-K; other site 1107880004935 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1107880004936 MutS domain III; Region: MutS_III; pfam05192 1107880004937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880004938 Walker A/P-loop; other site 1107880004939 ATP binding site [chemical binding]; other site 1107880004940 Q-loop/lid; other site 1107880004941 ABC transporter signature motif; other site 1107880004942 Walker B; other site 1107880004943 D-loop; other site 1107880004944 H-loop/switch region; other site 1107880004945 Smr domain; Region: Smr; pfam01713 1107880004946 Colicin V production protein; Region: Colicin_V; pfam02674 1107880004947 Cell division protein ZapA; Region: ZapA; pfam05164 1107880004948 ribonuclease HIII; Provisional; Region: PRK00996 1107880004949 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1107880004950 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1107880004951 RNA/DNA hybrid binding site [nucleotide binding]; other site 1107880004952 active site 1107880004953 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1107880004954 phosphodiesterase; Provisional; Region: PRK12704 1107880004955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880004956 Zn2+ binding site [ion binding]; other site 1107880004957 Mg2+ binding site [ion binding]; other site 1107880004958 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1107880004959 SmpB-tmRNA interface; other site 1107880004960 ribonuclease R; Region: RNase_R; TIGR02063 1107880004961 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1107880004962 RNB domain; Region: RNB; pfam00773 1107880004963 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1107880004964 RNA binding site [nucleotide binding]; other site 1107880004965 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1107880004966 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1107880004967 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1107880004968 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1107880004969 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1107880004970 Acylphosphatase; Region: Acylphosphatase; pfam00708 1107880004971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1107880004972 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1107880004973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880004974 dimer interface [polypeptide binding]; other site 1107880004975 phosphorylation site [posttranslational modification] 1107880004976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880004977 ATP binding site [chemical binding]; other site 1107880004978 Mg2+ binding site [ion binding]; other site 1107880004979 G-X-G motif; other site 1107880004980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880004981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880004982 active site 1107880004983 phosphorylation site [posttranslational modification] 1107880004984 intermolecular recognition site; other site 1107880004985 dimerization interface [polypeptide binding]; other site 1107880004986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880004987 DNA binding site [nucleotide binding] 1107880004988 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1107880004989 hypothetical protein; Provisional; Region: PRK13670 1107880004990 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1107880004991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880004992 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1107880004993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1107880004994 Zn2+ binding site [ion binding]; other site 1107880004995 Mg2+ binding site [ion binding]; other site 1107880004996 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1107880004997 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1107880004998 active site 1107880004999 (T/H)XGH motif; other site 1107880005000 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1107880005001 GTPase YqeH; Provisional; Region: PRK13796 1107880005002 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1107880005003 GTP/Mg2+ binding site [chemical binding]; other site 1107880005004 G4 box; other site 1107880005005 G5 box; other site 1107880005006 G1 box; other site 1107880005007 Switch I region; other site 1107880005008 G2 box; other site 1107880005009 G3 box; other site 1107880005010 Switch II region; other site 1107880005011 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1107880005012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880005013 active site 1107880005014 motif I; other site 1107880005015 motif II; other site 1107880005016 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1107880005017 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1107880005018 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1107880005019 NAD binding site [chemical binding]; other site 1107880005020 substrate binding site [chemical binding]; other site 1107880005021 putative active site [active] 1107880005022 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1107880005023 dimer interface [polypeptide binding]; other site 1107880005024 FMN binding site [chemical binding]; other site 1107880005025 Predicted transcriptional regulator [Transcription]; Region: COG1959 1107880005026 Transcriptional regulator; Region: Rrf2; pfam02082 1107880005027 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1107880005028 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005029 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005030 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005031 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1107880005032 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880005033 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005034 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005035 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005036 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005037 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1107880005038 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1107880005039 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1107880005040 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1107880005041 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1107880005042 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1107880005043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005044 non-specific DNA binding site [nucleotide binding]; other site 1107880005045 salt bridge; other site 1107880005046 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005047 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005049 non-specific DNA binding site [nucleotide binding]; other site 1107880005050 salt bridge; other site 1107880005051 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005052 UPF0278 family; Region: UPF0278; cl17319 1107880005053 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1107880005054 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005055 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 1107880005056 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1107880005057 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005058 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005059 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005060 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005061 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005062 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1107880005063 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1107880005064 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1107880005065 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1107880005066 D-lactate dehydrogenase; Validated; Region: PRK08605 1107880005067 homodimer interface [polypeptide binding]; other site 1107880005068 ligand binding site [chemical binding]; other site 1107880005069 NAD binding site [chemical binding]; other site 1107880005070 catalytic site [active] 1107880005071 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1107880005072 UbiA prenyltransferase family; Region: UbiA; pfam01040 1107880005073 Predicted membrane protein [Function unknown]; Region: COG2323 1107880005074 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1107880005075 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1107880005076 trimer interface [polypeptide binding]; other site 1107880005077 active site 1107880005078 G bulge; other site 1107880005079 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1107880005080 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1107880005081 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1107880005082 ring oligomerisation interface [polypeptide binding]; other site 1107880005083 ATP/Mg binding site [chemical binding]; other site 1107880005084 stacking interactions; other site 1107880005085 hinge regions; other site 1107880005086 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1107880005087 oligomerisation interface [polypeptide binding]; other site 1107880005088 mobile loop; other site 1107880005089 roof hairpin; other site 1107880005090 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1107880005091 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1107880005092 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1107880005093 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1107880005094 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1107880005095 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1107880005096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1107880005097 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1107880005098 active pocket/dimerization site; other site 1107880005099 active site 1107880005100 phosphorylation site [posttranslational modification] 1107880005101 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1107880005102 active site 1107880005103 phosphorylation site [posttranslational modification] 1107880005104 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1107880005105 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1107880005106 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1107880005107 dimer interface [polypeptide binding]; other site 1107880005108 FMN binding site [chemical binding]; other site 1107880005109 NADPH bind site [chemical binding]; other site 1107880005110 Predicted membrane protein [Function unknown]; Region: COG4129 1107880005111 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1107880005112 FemAB family; Region: FemAB; pfam02388 1107880005113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1107880005114 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1107880005115 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1107880005116 CoA binding domain; Region: CoA_binding; pfam02629 1107880005117 UGMP family protein; Validated; Region: PRK09604 1107880005118 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1107880005119 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1107880005120 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1107880005121 Coenzyme A binding pocket [chemical binding]; other site 1107880005122 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1107880005123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880005124 Coenzyme A binding pocket [chemical binding]; other site 1107880005125 Glycoprotease family; Region: Peptidase_M22; pfam00814 1107880005126 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1107880005127 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1107880005128 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1107880005129 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1107880005130 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1107880005131 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1107880005132 dimerization domain swap beta strand [polypeptide binding]; other site 1107880005133 regulatory protein interface [polypeptide binding]; other site 1107880005134 active site 1107880005135 regulatory phosphorylation site [posttranslational modification]; other site 1107880005136 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1107880005137 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1107880005138 active site 1107880005139 Zn binding site [ion binding]; other site 1107880005140 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1107880005141 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1107880005142 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1107880005143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880005144 S-adenosylmethionine binding site [chemical binding]; other site 1107880005145 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1107880005146 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1107880005147 RF-1 domain; Region: RF-1; pfam00472 1107880005148 thymidine kinase; Provisional; Region: PRK04296 1107880005149 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005150 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1107880005151 NlpC/P60 family; Region: NLPC_P60; cl17555 1107880005152 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1107880005153 active site 1107880005154 dimerization interface [polypeptide binding]; other site 1107880005155 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1107880005156 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1107880005157 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1107880005158 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1107880005159 catalytic triad [active] 1107880005160 Pheromone A receptor; Region: STE3; pfam02076 1107880005161 Amino acid permease; Region: AA_permease_2; pfam13520 1107880005162 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1107880005163 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1107880005164 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1107880005165 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1107880005166 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1107880005167 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1107880005168 THF binding site; other site 1107880005169 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1107880005170 substrate binding site [chemical binding]; other site 1107880005171 THF binding site; other site 1107880005172 zinc-binding site [ion binding]; other site 1107880005173 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1107880005174 FAD binding site [chemical binding]; other site 1107880005175 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1107880005176 Peptidase C26; Region: Peptidase_C26; pfam07722 1107880005177 catalytic triad [active] 1107880005178 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1107880005179 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1107880005180 peptide binding site [polypeptide binding]; other site 1107880005181 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1107880005182 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1107880005183 homodimer interface [polypeptide binding]; other site 1107880005184 substrate-cofactor binding pocket; other site 1107880005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880005186 catalytic residue [active] 1107880005187 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1107880005188 substrate binding site [chemical binding]; other site 1107880005189 THF binding site; other site 1107880005190 zinc-binding site [ion binding]; other site 1107880005191 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1107880005192 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1107880005193 substrate binding site [chemical binding]; other site 1107880005194 THF binding site; other site 1107880005195 zinc-binding site [ion binding]; other site 1107880005196 cystathionine beta-lyase; Provisional; Region: PRK08064 1107880005197 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1107880005198 homodimer interface [polypeptide binding]; other site 1107880005199 substrate-cofactor binding pocket; other site 1107880005200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880005201 catalytic residue [active] 1107880005202 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1107880005203 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1107880005204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1107880005205 catalytic residue [active] 1107880005206 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1107880005207 proposed active site lysine [active] 1107880005208 conserved cys residue [active] 1107880005209 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880005210 catalytic residues [active] 1107880005211 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1107880005212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1107880005213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880005214 dimer interface [polypeptide binding]; other site 1107880005215 phosphorylation site [posttranslational modification] 1107880005216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880005217 ATP binding site [chemical binding]; other site 1107880005218 Mg2+ binding site [ion binding]; other site 1107880005219 G-X-G motif; other site 1107880005220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880005221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880005222 active site 1107880005223 phosphorylation site [posttranslational modification] 1107880005224 intermolecular recognition site; other site 1107880005225 dimerization interface [polypeptide binding]; other site 1107880005226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880005227 DNA binding site [nucleotide binding] 1107880005228 PemK-like protein; Region: PemK; pfam02452 1107880005229 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1107880005230 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1107880005231 active site 1107880005232 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1107880005233 dimer interface [polypeptide binding]; other site 1107880005234 substrate binding site [chemical binding]; other site 1107880005235 catalytic residues [active] 1107880005236 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1107880005237 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1107880005238 DltD N-terminal region; Region: DltD_N; pfam04915 1107880005239 DltD central region; Region: DltD_M; pfam04918 1107880005240 DltD C-terminal region; Region: DltD_C; pfam04914 1107880005241 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1107880005242 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1107880005243 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1107880005244 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1107880005245 acyl-activating enzyme (AAE) consensus motif; other site 1107880005246 AMP binding site [chemical binding]; other site 1107880005247 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1107880005248 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1107880005249 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1107880005250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1107880005251 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1107880005252 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1107880005253 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1107880005254 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1107880005255 active site 1107880005256 metal binding site [ion binding]; metal-binding site 1107880005257 dimerization interface [polypeptide binding]; other site 1107880005258 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1107880005259 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1107880005260 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1107880005261 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1107880005262 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1107880005263 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1107880005264 cleft; other site 1107880005265 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1107880005266 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1107880005267 DNA binding site [nucleotide binding] 1107880005268 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1107880005269 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1107880005270 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1107880005271 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1107880005272 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1107880005273 RPB1 interaction site [polypeptide binding]; other site 1107880005274 RPB10 interaction site [polypeptide binding]; other site 1107880005275 RPB11 interaction site [polypeptide binding]; other site 1107880005276 RPB3 interaction site [polypeptide binding]; other site 1107880005277 RPB12 interaction site [polypeptide binding]; other site 1107880005278 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1107880005279 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1107880005280 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1107880005281 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1107880005282 homodimer interface [polypeptide binding]; other site 1107880005283 ligand binding site [chemical binding]; other site 1107880005284 NAD binding site [chemical binding]; other site 1107880005285 catalytic site [active] 1107880005286 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1107880005287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880005288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880005289 homodimer interface [polypeptide binding]; other site 1107880005290 catalytic residue [active] 1107880005291 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1107880005292 active site 1107880005293 amino acid transporter; Region: 2A0306; TIGR00909 1107880005294 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1107880005295 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1107880005296 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1107880005297 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1107880005298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1107880005299 RNA binding surface [nucleotide binding]; other site 1107880005300 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1107880005301 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1107880005302 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1107880005303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880005305 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1107880005306 recombination factor protein RarA; Reviewed; Region: PRK13342 1107880005307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1107880005308 Walker A motif; other site 1107880005309 ATP binding site [chemical binding]; other site 1107880005310 Walker B motif; other site 1107880005311 arginine finger; other site 1107880005312 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1107880005313 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1107880005314 Ligand Binding Site [chemical binding]; other site 1107880005315 lysine transporter; Provisional; Region: PRK10836 1107880005316 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1107880005317 active site 1107880005318 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1107880005319 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1107880005320 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1107880005321 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1107880005322 active site 1107880005323 HIGH motif; other site 1107880005324 dimer interface [polypeptide binding]; other site 1107880005325 KMSKS motif; other site 1107880005326 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1107880005327 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1107880005328 HflX GTPase family; Region: HflX; cd01878 1107880005329 G1 box; other site 1107880005330 GTP/Mg2+ binding site [chemical binding]; other site 1107880005331 Switch I region; other site 1107880005332 G2 box; other site 1107880005333 G3 box; other site 1107880005334 Switch II region; other site 1107880005335 G4 box; other site 1107880005336 G5 box; other site 1107880005337 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1107880005338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1107880005339 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1107880005340 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1107880005341 minor groove reading motif; other site 1107880005342 helix-hairpin-helix signature motif; other site 1107880005343 substrate binding pocket [chemical binding]; other site 1107880005344 active site 1107880005345 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1107880005346 DNA binding and oxoG recognition site [nucleotide binding] 1107880005347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880005349 putative substrate translocation pore; other site 1107880005350 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1107880005351 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1107880005352 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1107880005353 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1107880005354 putative active site [active] 1107880005355 putative FMN binding site [chemical binding]; other site 1107880005356 putative substrate binding site [chemical binding]; other site 1107880005357 putative catalytic residue [active] 1107880005358 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1107880005359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1107880005360 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1107880005361 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1107880005362 gamma subunit interface [polypeptide binding]; other site 1107880005363 epsilon subunit interface [polypeptide binding]; other site 1107880005364 LBP interface [polypeptide binding]; other site 1107880005365 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1107880005366 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1107880005367 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1107880005368 alpha subunit interaction interface [polypeptide binding]; other site 1107880005369 Walker A motif; other site 1107880005370 ATP binding site [chemical binding]; other site 1107880005371 Walker B motif; other site 1107880005372 inhibitor binding site; inhibition site 1107880005373 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1107880005374 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1107880005375 core domain interface [polypeptide binding]; other site 1107880005376 delta subunit interface [polypeptide binding]; other site 1107880005377 epsilon subunit interface [polypeptide binding]; other site 1107880005378 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1107880005379 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1107880005380 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1107880005381 beta subunit interaction interface [polypeptide binding]; other site 1107880005382 Walker A motif; other site 1107880005383 ATP binding site [chemical binding]; other site 1107880005384 Walker B motif; other site 1107880005385 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1107880005386 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1107880005387 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1107880005388 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1107880005389 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1107880005390 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1107880005391 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1107880005392 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1107880005393 uracil transporter; Provisional; Region: PRK10720 1107880005394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880005395 catalytic core [active] 1107880005396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1107880005397 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1107880005398 DNA-binding site [nucleotide binding]; DNA binding site 1107880005399 RNA-binding motif; other site 1107880005400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005401 putative substrate translocation pore; other site 1107880005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005403 pantothenate kinase; Provisional; Region: PRK05439 1107880005404 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1107880005405 active site 1107880005406 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1107880005407 Part of AAA domain; Region: AAA_19; pfam13245 1107880005408 Family description; Region: UvrD_C_2; pfam13538 1107880005409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1107880005410 MarR family; Region: MarR; pfam01047 1107880005411 MarR family; Region: MarR_2; cl17246 1107880005412 Cation efflux family; Region: Cation_efflux; pfam01545 1107880005413 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1107880005414 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1107880005415 active site 1107880005416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880005417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1107880005418 Coenzyme A binding pocket [chemical binding]; other site 1107880005419 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1107880005420 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1107880005421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1107880005422 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1107880005423 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1107880005424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005426 non-specific DNA binding site [nucleotide binding]; other site 1107880005427 salt bridge; other site 1107880005428 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005431 non-specific DNA binding site [nucleotide binding]; other site 1107880005432 salt bridge; other site 1107880005433 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005434 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1107880005435 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1107880005436 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1107880005437 active site 1107880005438 Predicted membrane protein [Function unknown]; Region: COG1511 1107880005439 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1107880005440 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1107880005441 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1107880005442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1107880005443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880005444 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1107880005445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880005446 DNA-binding site [nucleotide binding]; DNA binding site 1107880005447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1107880005448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880005449 homodimer interface [polypeptide binding]; other site 1107880005450 catalytic residue [active] 1107880005451 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1107880005452 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1107880005453 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1107880005454 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 1107880005455 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1107880005456 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1107880005457 Coenzyme A binding pocket [chemical binding]; other site 1107880005458 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1107880005459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1107880005460 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1107880005461 topology modulation protein; Reviewed; Region: PRK08118 1107880005462 AAA domain; Region: AAA_17; pfam13207 1107880005463 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1107880005464 AAA domain; Region: AAA_30; pfam13604 1107880005465 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1107880005466 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1107880005467 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1107880005468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1107880005469 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1107880005470 TspO/MBR family; Region: TspO_MBR; pfam03073 1107880005471 VanW like protein; Region: VanW; pfam04294 1107880005472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005474 non-specific DNA binding site [nucleotide binding]; other site 1107880005475 salt bridge; other site 1107880005476 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1107880005478 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1107880005479 Family description; Region: ACT_7; pfam13840 1107880005480 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1107880005481 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880005482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880005483 ABC transporter; Region: ABC_tran_2; pfam12848 1107880005484 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1107880005485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005486 non-specific DNA binding site [nucleotide binding]; other site 1107880005487 salt bridge; other site 1107880005488 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005489 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1107880005490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1107880005491 active site 1107880005492 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1107880005493 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1107880005494 NAD binding site [chemical binding]; other site 1107880005495 substrate binding site [chemical binding]; other site 1107880005496 catalytic Zn binding site [ion binding]; other site 1107880005497 tetramer interface [polypeptide binding]; other site 1107880005498 structural Zn binding site [ion binding]; other site 1107880005499 benzoate transport; Region: 2A0115; TIGR00895 1107880005500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005501 putative substrate translocation pore; other site 1107880005502 Phosphoglycerate kinase; Region: PGK; pfam00162 1107880005503 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1107880005504 substrate binding site [chemical binding]; other site 1107880005505 hinge regions; other site 1107880005506 ADP binding site [chemical binding]; other site 1107880005507 catalytic site [active] 1107880005508 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1107880005509 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1107880005510 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1107880005511 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1107880005512 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1107880005513 active site 1107880005514 Zn binding site [ion binding]; other site 1107880005515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1107880005516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1107880005517 Walker A/P-loop; other site 1107880005518 ATP binding site [chemical binding]; other site 1107880005519 Q-loop/lid; other site 1107880005520 ABC transporter signature motif; other site 1107880005521 Walker B; other site 1107880005522 D-loop; other site 1107880005523 H-loop/switch region; other site 1107880005524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1107880005525 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1107880005526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1107880005527 Walker A/P-loop; other site 1107880005528 ATP binding site [chemical binding]; other site 1107880005529 Q-loop/lid; other site 1107880005530 ABC transporter signature motif; other site 1107880005531 Walker B; other site 1107880005532 D-loop; other site 1107880005533 H-loop/switch region; other site 1107880005534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1107880005535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1107880005536 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1107880005537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880005538 dimer interface [polypeptide binding]; other site 1107880005539 conserved gate region; other site 1107880005540 putative PBP binding loops; other site 1107880005541 ABC-ATPase subunit interface; other site 1107880005542 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1107880005543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880005544 dimer interface [polypeptide binding]; other site 1107880005545 conserved gate region; other site 1107880005546 putative PBP binding loops; other site 1107880005547 ABC-ATPase subunit interface; other site 1107880005548 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1107880005549 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1107880005550 peptide binding site [polypeptide binding]; other site 1107880005551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880005552 dimer interface [polypeptide binding]; other site 1107880005553 putative PBP binding loops; other site 1107880005554 ABC-ATPase subunit interface; other site 1107880005555 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1107880005556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1107880005557 dimer interface [polypeptide binding]; other site 1107880005558 conserved gate region; other site 1107880005559 putative PBP binding loops; other site 1107880005560 ABC-ATPase subunit interface; other site 1107880005561 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1107880005562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1107880005563 substrate binding pocket [chemical binding]; other site 1107880005564 membrane-bound complex binding site; other site 1107880005565 hinge residues; other site 1107880005566 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1107880005567 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1107880005568 Walker A/P-loop; other site 1107880005569 ATP binding site [chemical binding]; other site 1107880005570 Q-loop/lid; other site 1107880005571 ABC transporter signature motif; other site 1107880005572 Walker B; other site 1107880005573 D-loop; other site 1107880005574 H-loop/switch region; other site 1107880005575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1107880005576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880005577 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1107880005578 Walker A/P-loop; other site 1107880005579 ATP binding site [chemical binding]; other site 1107880005580 Q-loop/lid; other site 1107880005581 ABC transporter signature motif; other site 1107880005582 Walker B; other site 1107880005583 D-loop; other site 1107880005584 H-loop/switch region; other site 1107880005585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1107880005586 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1107880005587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880005588 Walker A/P-loop; other site 1107880005589 ATP binding site [chemical binding]; other site 1107880005590 Q-loop/lid; other site 1107880005591 ABC transporter signature motif; other site 1107880005592 Walker B; other site 1107880005593 D-loop; other site 1107880005594 H-loop/switch region; other site 1107880005595 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1107880005596 putative active site [active] 1107880005597 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1107880005598 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1107880005599 alanine racemase; Reviewed; Region: alr; PRK00053 1107880005600 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1107880005601 active site 1107880005602 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1107880005603 dimer interface [polypeptide binding]; other site 1107880005604 substrate binding site [chemical binding]; other site 1107880005605 catalytic residues [active] 1107880005606 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1107880005607 Predicted transcriptional regulator [Transcription]; Region: COG1959 1107880005608 Transcriptional regulator; Region: Rrf2; pfam02082 1107880005609 Predicted membrane protein [Function unknown]; Region: COG1511 1107880005610 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1107880005611 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1107880005612 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1107880005613 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1107880005614 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1107880005615 protein binding site [polypeptide binding]; other site 1107880005616 YycH protein; Region: YycI; pfam09648 1107880005617 YycH protein; Region: YycH; pfam07435 1107880005618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1107880005619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1107880005620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1107880005621 dimerization interface [polypeptide binding]; other site 1107880005622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1107880005623 putative active site [active] 1107880005624 heme pocket [chemical binding]; other site 1107880005625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1107880005626 dimer interface [polypeptide binding]; other site 1107880005627 phosphorylation site [posttranslational modification] 1107880005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1107880005629 ATP binding site [chemical binding]; other site 1107880005630 Mg2+ binding site [ion binding]; other site 1107880005631 G-X-G motif; other site 1107880005632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1107880005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1107880005634 active site 1107880005635 phosphorylation site [posttranslational modification] 1107880005636 intermolecular recognition site; other site 1107880005637 dimerization interface [polypeptide binding]; other site 1107880005638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1107880005639 DNA binding site [nucleotide binding] 1107880005640 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1107880005641 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1107880005642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880005643 active site 1107880005644 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1107880005645 dimer interface [polypeptide binding]; other site 1107880005646 catalytic triad [active] 1107880005647 peroxidatic and resolving cysteines [active] 1107880005648 sugar phosphate phosphatase; Provisional; Region: PRK10513 1107880005649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880005650 active site 1107880005651 motif I; other site 1107880005652 motif II; other site 1107880005653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880005654 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1107880005655 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1107880005656 homotrimer interaction site [polypeptide binding]; other site 1107880005657 putative active site [active] 1107880005658 threonine dehydratase; Validated; Region: PRK08639 1107880005659 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1107880005660 tetramer interface [polypeptide binding]; other site 1107880005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1107880005662 catalytic residue [active] 1107880005663 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1107880005664 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1107880005665 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1107880005666 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1107880005667 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1107880005668 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1107880005669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1107880005670 PYR/PP interface [polypeptide binding]; other site 1107880005671 dimer interface [polypeptide binding]; other site 1107880005672 TPP binding site [chemical binding]; other site 1107880005673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1107880005674 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1107880005675 TPP-binding site [chemical binding]; other site 1107880005676 dimer interface [polypeptide binding]; other site 1107880005677 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1107880005678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880005679 Walker A/P-loop; other site 1107880005680 ATP binding site [chemical binding]; other site 1107880005681 Q-loop/lid; other site 1107880005682 ABC transporter signature motif; other site 1107880005683 Walker B; other site 1107880005684 D-loop; other site 1107880005685 H-loop/switch region; other site 1107880005686 putative phosphoketolase; Provisional; Region: PRK05261 1107880005687 XFP N-terminal domain; Region: XFP_N; pfam09364 1107880005688 XFP C-terminal domain; Region: XFP_C; pfam09363 1107880005689 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1107880005690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1107880005691 DNA-binding site [nucleotide binding]; DNA binding site 1107880005692 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1107880005693 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1107880005694 putative deacylase active site [active] 1107880005695 SprT homologues; Region: SprT; cl01182 1107880005696 replicative DNA helicase; Region: DnaB; TIGR00665 1107880005697 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1107880005698 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1107880005699 Walker A motif; other site 1107880005700 ATP binding site [chemical binding]; other site 1107880005701 Walker B motif; other site 1107880005702 DNA binding loops [nucleotide binding] 1107880005703 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1107880005704 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1107880005705 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1107880005706 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1107880005707 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1107880005708 DHH family; Region: DHH; pfam01368 1107880005709 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1107880005710 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1107880005711 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1107880005712 dimer interface [polypeptide binding]; other site 1107880005713 ssDNA binding site [nucleotide binding]; other site 1107880005714 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1107880005715 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1107880005716 dipeptidase PepV; Reviewed; Region: PRK07318 1107880005717 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1107880005718 active site 1107880005719 metal binding site [ion binding]; metal-binding site 1107880005720 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1107880005721 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1107880005722 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880005723 Walker A/P-loop; other site 1107880005724 ATP binding site [chemical binding]; other site 1107880005725 Q-loop/lid; other site 1107880005726 ABC transporter signature motif; other site 1107880005727 Walker B; other site 1107880005728 D-loop; other site 1107880005729 H-loop/switch region; other site 1107880005730 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1107880005731 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1107880005732 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880005733 Walker A/P-loop; other site 1107880005734 ATP binding site [chemical binding]; other site 1107880005735 Q-loop/lid; other site 1107880005736 ABC transporter signature motif; other site 1107880005737 Walker B; other site 1107880005738 D-loop; other site 1107880005739 H-loop/switch region; other site 1107880005740 hypothetical protein; Provisional; Region: PRK13661 1107880005741 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1107880005742 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1107880005743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1107880005744 ATP binding site [chemical binding]; other site 1107880005745 putative Mg++ binding site [ion binding]; other site 1107880005746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1107880005747 nucleotide binding region [chemical binding]; other site 1107880005748 ATP-binding site [chemical binding]; other site 1107880005749 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1107880005750 HRDC domain; Region: HRDC; pfam00570 1107880005751 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005753 non-specific DNA binding site [nucleotide binding]; other site 1107880005754 salt bridge; other site 1107880005755 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005756 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1107880005757 active site 1107880005758 Int/Topo IB signature motif; other site 1107880005759 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1107880005760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005761 non-specific DNA binding site [nucleotide binding]; other site 1107880005762 salt bridge; other site 1107880005763 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005764 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1107880005765 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1107880005766 intersubunit interface [polypeptide binding]; other site 1107880005767 active site 1107880005768 Zn2+ binding site [ion binding]; other site 1107880005769 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1107880005770 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1107880005771 AP (apurinic/apyrimidinic) site pocket; other site 1107880005772 DNA interaction; other site 1107880005773 Metal-binding active site; metal-binding site 1107880005774 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1107880005775 active site 1107880005776 dimer interface [polypeptide binding]; other site 1107880005777 magnesium binding site [ion binding]; other site 1107880005778 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1107880005779 active site 1107880005780 P-loop; other site 1107880005781 phosphorylation site [posttranslational modification] 1107880005782 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1107880005783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1107880005784 active site 1107880005785 phosphorylation site [posttranslational modification] 1107880005786 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1107880005787 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1107880005788 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1107880005789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880005790 active site 1107880005791 motif I; other site 1107880005792 motif II; other site 1107880005793 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1107880005794 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1107880005795 Predicted membrane protein [Function unknown]; Region: COG3428 1107880005796 Bacterial PH domain; Region: DUF304; pfam03703 1107880005797 Bacterial PH domain; Region: DUF304; cl01348 1107880005798 Predicted transcriptional regulators [Transcription]; Region: COG1695 1107880005799 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1107880005800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880005801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005802 putative substrate translocation pore; other site 1107880005803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880005804 Coenzyme A binding pocket [chemical binding]; other site 1107880005805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1107880005806 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1107880005807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1107880005808 dimerization interface [polypeptide binding]; other site 1107880005809 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1107880005810 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1107880005811 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1107880005812 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1107880005813 putative active site [active] 1107880005814 putative FMN binding site [chemical binding]; other site 1107880005815 putative substrate binding site [chemical binding]; other site 1107880005816 putative catalytic residue [active] 1107880005817 Predicted transcriptional regulators [Transcription]; Region: COG1733 1107880005818 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1107880005819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880005820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880005821 active site 1107880005822 catalytic tetrad [active] 1107880005823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1107880005824 MarR family; Region: MarR_2; cl17246 1107880005825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1107880005826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1107880005827 active site 1107880005828 catalytic tetrad [active] 1107880005829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1107880005831 putative substrate translocation pore; other site 1107880005832 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1107880005833 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1107880005834 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1107880005835 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1107880005836 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1107880005837 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1107880005838 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1107880005839 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1107880005840 metal binding site [ion binding]; metal-binding site 1107880005841 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1107880005842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1107880005843 S-adenosylmethionine binding site [chemical binding]; other site 1107880005844 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1107880005845 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1107880005846 acyl-activating enzyme (AAE) consensus motif; other site 1107880005847 putative AMP binding site [chemical binding]; other site 1107880005848 putative active site [active] 1107880005849 putative CoA binding site [chemical binding]; other site 1107880005850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1107880005851 Coenzyme A binding pocket [chemical binding]; other site 1107880005852 potential frameshift: common BLAST hit: gi|116619095|ref|YP_819466.1| high-affinity nickel permease 1107880005853 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1107880005854 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1107880005855 Predicted membrane protein [Function unknown]; Region: COG4709 1107880005856 Predicted transcriptional regulators [Transcription]; Region: COG1695 1107880005857 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1107880005858 benzoate transport; Region: 2A0115; TIGR00895 1107880005859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880005860 putative substrate translocation pore; other site 1107880005861 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1107880005862 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1107880005863 substrate binding site [chemical binding]; other site 1107880005864 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1107880005865 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1107880005866 substrate binding site [chemical binding]; other site 1107880005867 ligand binding site [chemical binding]; other site 1107880005868 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1107880005869 tartrate dehydrogenase; Region: TTC; TIGR02089 1107880005870 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1107880005871 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1107880005872 active site 1107880005873 catalytic residues [active] 1107880005874 metal binding site [ion binding]; metal-binding site 1107880005875 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1107880005876 FeS assembly protein SufB; Region: sufB; TIGR01980 1107880005877 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1107880005878 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1107880005879 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1107880005880 trimerization site [polypeptide binding]; other site 1107880005881 active site 1107880005882 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1107880005883 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1107880005884 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1107880005885 catalytic residue [active] 1107880005886 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1107880005887 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1107880005888 FeS assembly protein SufD; Region: sufD; TIGR01981 1107880005889 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1107880005890 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1107880005891 Walker A/P-loop; other site 1107880005892 ATP binding site [chemical binding]; other site 1107880005893 Q-loop/lid; other site 1107880005894 ABC transporter signature motif; other site 1107880005895 Walker B; other site 1107880005896 D-loop; other site 1107880005897 H-loop/switch region; other site 1107880005898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005899 non-specific DNA binding site [nucleotide binding]; other site 1107880005900 salt bridge; other site 1107880005901 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005902 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1107880005903 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1107880005904 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1107880005905 Sodium Bile acid symporter family; Region: SBF; pfam01758 1107880005906 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1107880005907 D-lactate dehydrogenase; Validated; Region: PRK08605 1107880005908 homodimer interface [polypeptide binding]; other site 1107880005909 ligand binding site [chemical binding]; other site 1107880005910 NAD binding site [chemical binding]; other site 1107880005911 catalytic site [active] 1107880005912 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1107880005913 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1107880005914 active site 1107880005915 HIGH motif; other site 1107880005916 dimer interface [polypeptide binding]; other site 1107880005917 KMSKS motif; other site 1107880005918 S4 RNA-binding domain; Region: S4; smart00363 1107880005919 RNA binding surface [nucleotide binding]; other site 1107880005920 Predicted transcriptional regulators [Transcription]; Region: COG1695 1107880005921 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1107880005922 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1107880005923 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1107880005924 PspC domain; Region: PspC; pfam04024 1107880005925 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1107880005926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1107880005927 substrate binding pocket [chemical binding]; other site 1107880005928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1107880005929 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1107880005930 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1107880005931 FtsX-like permease family; Region: FtsX; pfam02687 1107880005932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1107880005933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1107880005934 Walker A/P-loop; other site 1107880005935 ATP binding site [chemical binding]; other site 1107880005936 Q-loop/lid; other site 1107880005937 ABC transporter signature motif; other site 1107880005938 Walker B; other site 1107880005939 D-loop; other site 1107880005940 H-loop/switch region; other site 1107880005941 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1107880005942 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1107880005943 HlyD family secretion protein; Region: HlyD_3; pfam13437 1107880005944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1107880005945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880005946 sequence-specific DNA binding site [nucleotide binding]; other site 1107880005947 salt bridge; other site 1107880005948 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1107880005949 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1107880005950 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1107880005951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1107880005952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1107880005953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1107880005954 dimerization interface [polypeptide binding]; other site 1107880005955 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1107880005956 active site 1107880005957 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1107880005958 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1107880005959 Cl binding site [ion binding]; other site 1107880005960 oligomer interface [polypeptide binding]; other site 1107880005961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1107880005962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880005963 Coenzyme A binding pocket [chemical binding]; other site 1107880005964 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1107880005965 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1107880005966 Catalytic site [active] 1107880005967 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1107880005968 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1107880005969 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1107880005970 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1107880005971 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1107880005972 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1107880005973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1107880005974 ligand binding site [chemical binding]; other site 1107880005975 flexible hinge region; other site 1107880005976 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1107880005977 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1107880005978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880005979 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880005980 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880005981 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1107880005982 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1107880005983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1107880005984 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1107880005985 active site 1107880005986 motif I; other site 1107880005987 motif II; other site 1107880005988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880005989 motif II; other site 1107880005990 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1107880005991 Membrane transport protein; Region: Mem_trans; pfam03547 1107880005992 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1107880005993 active site 1107880005994 zinc binding site [ion binding]; other site 1107880005995 Transposase; Region: HTH_Tnp_1; cl17663 1107880005996 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1107880005997 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1107880005998 catalytic residues [active] 1107880005999 catalytic nucleophile [active] 1107880006000 Presynaptic Site I dimer interface [polypeptide binding]; other site 1107880006001 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1107880006002 Synaptic Flat tetramer interface [polypeptide binding]; other site 1107880006003 Synaptic Site I dimer interface [polypeptide binding]; other site 1107880006004 DNA binding site [nucleotide binding] 1107880006005 CrcB-like protein; Region: CRCB; pfam02537 1107880006006 CrcB-like protein; Region: CRCB; cl09114 1107880006007 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1107880006008 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1107880006009 Cl- selectivity filter; other site 1107880006010 Cl- binding residues [ion binding]; other site 1107880006011 pore gating glutamate residue; other site 1107880006012 dimer interface [polypeptide binding]; other site 1107880006013 H+/Cl- coupling transport residue; other site 1107880006014 TrkA-C domain; Region: TrkA_C; pfam02080 1107880006015 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1107880006016 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1107880006017 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1107880006018 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1107880006019 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1107880006020 Transposase; Region: HTH_Tnp_1; cl17663 1107880006021 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1107880006022 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1107880006023 active site 1107880006024 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880006025 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1107880006026 P-loop; other site 1107880006027 Magnesium ion binding site [ion binding]; other site 1107880006028 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880006029 Magnesium ion binding site [ion binding]; other site 1107880006030 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1107880006031 multicopper oxidase; Provisional; Region: PRK10965 1107880006032 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1107880006033 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1107880006034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1107880006035 Transposase; Region: HTH_Tnp_1; cl17663 1107880006036 HTH-like domain; Region: HTH_21; pfam13276 1107880006037 Integrase core domain; Region: rve; pfam00665 1107880006038 Integrase core domain; Region: rve_2; pfam13333 1107880006039 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1107880006040 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1107880006041 TrkA-N domain; Region: TrkA_N; pfam02254 1107880006042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880006043 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880006044 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1107880006045 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1107880006046 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1107880006047 potential frameshift: common BLAST hit: gi|170016270|ref|YP_001722993.1| cation transport ATPase 1107880006048 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1107880006049 metal-binding site [ion binding] 1107880006050 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1107880006051 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1107880006052 dimerization interface [polypeptide binding]; other site 1107880006053 DPS ferroxidase diiron center [ion binding]; other site 1107880006054 ion pore; other site 1107880006055 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1107880006056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1107880006057 ligand binding site [chemical binding]; other site 1107880006058 flexible hinge region; other site 1107880006059 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1107880006060 putative switch regulator; other site 1107880006061 non-specific DNA interactions [nucleotide binding]; other site 1107880006062 DNA binding site [nucleotide binding] 1107880006063 sequence specific DNA binding site [nucleotide binding]; other site 1107880006064 putative cAMP binding site [chemical binding]; other site 1107880006065 CCC1-related family of proteins; Region: CCC1_like; cd01059 1107880006066 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1107880006067 active site 1107880006068 DNA binding site [nucleotide binding] 1107880006069 Int/Topo IB signature motif; other site 1107880006070 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1107880006071 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1107880006072 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1107880006073 Walker A/P-loop; other site 1107880006074 ATP binding site [chemical binding]; other site 1107880006075 Q-loop/lid; other site 1107880006076 ABC transporter signature motif; other site 1107880006077 Walker B; other site 1107880006078 D-loop; other site 1107880006079 H-loop/switch region; other site 1107880006080 Predicted transcriptional regulators [Transcription]; Region: COG1733 1107880006081 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1107880006082 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1107880006083 active site 1107880006084 dimer interface [polypeptide binding]; other site 1107880006085 magnesium binding site [ion binding]; other site 1107880006086 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1107880006087 tetramer interface [polypeptide binding]; other site 1107880006088 active site 1107880006089 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1107880006090 putative uracil binding site [chemical binding]; other site 1107880006091 putative active site [active] 1107880006092 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1107880006093 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1107880006094 Integrase core domain; Region: rve; pfam00665 1107880006095 Integrase core domain; Region: rve_2; pfam13333 1107880006096 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1107880006097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880006098 putative substrate translocation pore; other site 1107880006099 Transposase; Region: HTH_Tnp_1; pfam01527 1107880006100 HTH-like domain; Region: HTH_21; pfam13276 1107880006101 Integrase core domain; Region: rve; pfam00665 1107880006102 Integrase core domain; Region: rve_2; pfam13333 1107880006103 Predicted transcriptional regulator [Transcription]; Region: COG2378 1107880006104 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1107880006105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880006106 sequence-specific DNA binding site [nucleotide binding]; other site 1107880006107 salt bridge; other site 1107880006108 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1107880006109 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1107880006110 putative NAD(P) binding site [chemical binding]; other site 1107880006111 catalytic Zn binding site [ion binding]; other site 1107880006112 Predicted membrane protein [Function unknown]; Region: COG2364 1107880006113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1107880006114 active site 1107880006115 metal binding site [ion binding]; metal-binding site 1107880006116 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1107880006117 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1107880006118 nucleotide binding site [chemical binding]; other site 1107880006119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1107880006120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1107880006121 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1107880006122 active site 1107880006123 DNA binding site [nucleotide binding] 1107880006124 Int/Topo IB signature motif; other site 1107880006125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880006126 putative substrate translocation pore; other site 1107880006127 H+ Antiporter protein; Region: 2A0121; TIGR00900 1107880006128 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 1107880006129 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1107880006130 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1107880006131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1107880006132 motif II; other site 1107880006133 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1107880006134 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1107880006135 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1107880006136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1107880006137 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1107880006138 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1107880006139 phosphopentomutase; Provisional; Region: PRK05362 1107880006140 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1107880006141 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1107880006142 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1107880006143 substrate binding site [chemical binding]; other site 1107880006144 dimer interface [polypeptide binding]; other site 1107880006145 ATP binding site [chemical binding]; other site 1107880006146 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1107880006147 active site 1107880006148 catalytic residues [active] 1107880006149 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1107880006150 RelB antitoxin; Region: RelB; cl01171 1107880006151 PemK-like protein; Region: PemK; pfam02452 1107880006152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1107880006153 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1107880006154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1107880006155 putative DNA binding site [nucleotide binding]; other site 1107880006156 putative Zn2+ binding site [ion binding]; other site 1107880006157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880006158 Walker A/P-loop; other site 1107880006159 ATP binding site [chemical binding]; other site 1107880006160 Q-loop/lid; other site 1107880006161 AAA domain; Region: AAA_21; pfam13304 1107880006162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880006163 ABC transporter signature motif; other site 1107880006164 Walker B; other site 1107880006165 D-loop; other site 1107880006166 H-loop/switch region; other site 1107880006167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1107880006168 AAA domain; Region: AAA_21; pfam13304 1107880006169 Walker A/P-loop; other site 1107880006170 ATP binding site [chemical binding]; other site 1107880006171 Q-loop/lid; other site 1107880006172 ABC transporter signature motif; other site 1107880006173 Walker B; other site 1107880006174 D-loop; other site 1107880006175 H-loop/switch region; other site 1107880006176 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006177 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1107880006178 catalytic residues [active] 1107880006179 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1107880006180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880006181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880006182 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1107880006183 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1107880006184 active site residue [active] 1107880006185 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1107880006186 putative homodimer interface [polypeptide binding]; other site 1107880006187 putative homotetramer interface [polypeptide binding]; other site 1107880006188 putative metal binding site [ion binding]; other site 1107880006189 putative homodimer-homodimer interface [polypeptide binding]; other site 1107880006190 putative allosteric switch controlling residues; other site 1107880006191 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1107880006192 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1107880006193 potential frameshift: common BLAST hit: gi|308181749|ref|YP_003925877.1| GTP-binding protein LepA 1107880006194 Predicted transcriptional regulators [Transcription]; Region: COG1733 1107880006195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1107880006196 putative DNA binding site [nucleotide binding]; other site 1107880006197 putative Zn2+ binding site [ion binding]; other site 1107880006198 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1107880006199 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1107880006200 NAD binding site [chemical binding]; other site 1107880006201 substrate binding site [chemical binding]; other site 1107880006202 putative active site [active] 1107880006203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006204 catalytic residues [active] 1107880006205 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1107880006206 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1107880006207 catalytic residues [active] 1107880006208 catalytic nucleophile [active] 1107880006209 Presynaptic Site I dimer interface [polypeptide binding]; other site 1107880006210 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1107880006211 Synaptic Flat tetramer interface [polypeptide binding]; other site 1107880006212 Synaptic Site I dimer interface [polypeptide binding]; other site 1107880006213 DNA binding site [nucleotide binding] 1107880006214 DNA adenine methylase (dam); Region: dam; TIGR00571 1107880006215 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1107880006216 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1107880006217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1107880006218 Magnesium ion binding site [ion binding]; other site 1107880006219 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1107880006220 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1107880006221 cryptic adenine deaminase; Provisional; Region: PRK10027 1107880006222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1107880006223 non-specific DNA binding site [nucleotide binding]; other site 1107880006224 salt bridge; other site 1107880006225 sequence-specific DNA binding site [nucleotide binding]; other site 1107880006226 Replication initiation factor; Region: Rep_trans; pfam02486 1107880006227 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1107880006228 TcpE family; Region: TcpE; pfam12648 1107880006229 Antirestriction protein (ArdA); Region: ArdA; cl01953 1107880006230 AAA-like domain; Region: AAA_10; pfam12846 1107880006231 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1107880006232 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006233 catalytic residues [active] 1107880006234 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1107880006235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880006236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880006237 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006238 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1107880006239 catalytic residues [active] 1107880006240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006241 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1107880006242 catalytic residues [active] 1107880006243 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1107880006244 catalytic residues [active] 1107880006245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1107880006246 dimerization interface [polypeptide binding]; other site 1107880006247 putative DNA binding site [nucleotide binding]; other site 1107880006248 putative Zn2+ binding site [ion binding]; other site 1107880006249 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1107880006250 active site residue [active] 1107880006251 Predicted helicase [General function prediction only]; Region: COG4889 1107880006252 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1107880006253 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1107880006254 nucleotide binding region [chemical binding]; other site 1107880006255 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1107880006256 ATP-binding site [chemical binding]; other site 1107880006257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1107880006258 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1107880006259 Initiator Replication protein; Region: Rep_3; pfam01051 1107880006260 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 1107880006261 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1107880006262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1107880006263 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1107880006264 Coenzyme A binding pocket [chemical binding]; other site 1107880006265 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1107880006266 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1107880006267 substrate binding [chemical binding]; other site 1107880006268 active site 1107880006269 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1107880006270 galactoside permease; Reviewed; Region: lacY; PRK09528 1107880006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1107880006272 putative substrate translocation pore; other site 1107880006273 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1107880006274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1107880006275 DNA binding site [nucleotide binding] 1107880006276 domain linker motif; other site 1107880006277 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1107880006278 dimerization interface [polypeptide binding]; other site 1107880006279 ligand binding site [chemical binding]; other site 1107880006280 sodium binding site [ion binding]; other site 1107880006281 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1107880006282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1107880006283 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1107880006284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1107880006285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1107880006286 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1107880006287 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1107880006288 catalytic residues [active]