-- dump date 20140619_132017 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272626000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272626000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272626000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626000004 Walker A motif; other site 272626000005 ATP binding site [chemical binding]; other site 272626000006 Walker B motif; other site 272626000007 arginine finger; other site 272626000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272626000009 DnaA box-binding interface [nucleotide binding]; other site 272626000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 272626000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272626000012 putative DNA binding surface [nucleotide binding]; other site 272626000013 dimer interface [polypeptide binding]; other site 272626000014 beta-clamp/clamp loader binding surface; other site 272626000015 beta-clamp/translesion DNA polymerase binding surface; other site 272626000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272626000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 272626000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 272626000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 272626000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272626000021 Walker A/P-loop; other site 272626000022 ATP binding site [chemical binding]; other site 272626000023 Q-loop/lid; other site 272626000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626000025 ABC transporter signature motif; other site 272626000026 Walker B; other site 272626000027 D-loop; other site 272626000028 H-loop/switch region; other site 272626000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272626000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626000031 Mg2+ binding site [ion binding]; other site 272626000032 G-X-G motif; other site 272626000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272626000034 anchoring element; other site 272626000035 dimer interface [polypeptide binding]; other site 272626000036 ATP binding site [chemical binding]; other site 272626000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272626000038 active site 272626000039 putative metal-binding site [ion binding]; other site 272626000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272626000041 DNA gyrase subunit A; Validated; Region: PRK05560 272626000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272626000043 CAP-like domain; other site 272626000044 active site 272626000045 primary dimer interface [polypeptide binding]; other site 272626000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626000051 cardiolipin synthetase; Reviewed; Region: PRK12452 272626000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272626000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272626000054 putative active site [active] 272626000055 catalytic site [active] 272626000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272626000057 putative active site [active] 272626000058 catalytic site [active] 272626000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272626000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626000061 Coenzyme A binding pocket [chemical binding]; other site 272626000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 272626000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272626000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272626000065 diphosphomevalonate decarboxylase; Region: PLN02407 272626000066 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272626000067 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 272626000068 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272626000069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 272626000070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272626000071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 272626000072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272626000073 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272626000074 D-pathway; other site 272626000075 Putative ubiquinol binding site [chemical binding]; other site 272626000076 Low-spin heme (heme b) binding site [chemical binding]; other site 272626000077 Putative water exit pathway; other site 272626000078 Binuclear center (heme o3/CuB) [ion binding]; other site 272626000079 K-pathway; other site 272626000080 Putative proton exit pathway; other site 272626000081 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272626000082 Subunit I/III interface [polypeptide binding]; other site 272626000083 Subunit III/IV interface [polypeptide binding]; other site 272626000084 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 272626000085 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272626000086 beta-galactosidase; Region: BGL; TIGR03356 272626000087 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 272626000088 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626000089 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 272626000090 putative active site [active] 272626000091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626000092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626000093 DNA-binding site [nucleotide binding]; DNA binding site 272626000094 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272626000095 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626000096 active site 272626000097 active pocket/dimerization site; other site 272626000098 phosphorylation site [posttranslational modification] 272626000099 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272626000100 active site 272626000101 phosphorylation site [posttranslational modification] 272626000102 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 272626000103 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 272626000104 hypothetical protein; Provisional; Region: PRK02947 272626000105 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626000106 putative active site [active] 272626000107 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 272626000108 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272626000109 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272626000110 active site turn [active] 272626000111 phosphorylation site [posttranslational modification] 272626000112 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272626000113 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272626000114 HPr interaction site; other site 272626000115 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272626000116 active site 272626000117 phosphorylation site [posttranslational modification] 272626000118 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272626000119 putative dimer interface [polypeptide binding]; other site 272626000120 catalytic triad [active] 272626000121 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626000122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000123 active site 272626000124 motif I; other site 272626000125 motif II; other site 272626000126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626000128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626000129 DNA binding site [nucleotide binding] 272626000130 domain linker motif; other site 272626000131 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 272626000132 dimerization interface [polypeptide binding]; other site 272626000133 putative ligand binding site [chemical binding]; other site 272626000134 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626000135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626000136 nucleotide binding site [chemical binding]; other site 272626000137 Butyrate kinase [Energy production and conversion]; Region: COG3426 272626000138 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 272626000139 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 272626000140 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626000141 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626000142 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272626000143 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272626000144 dimer interface [polypeptide binding]; other site 272626000145 active site 272626000146 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272626000147 dimer interface [polypeptide binding]; other site 272626000148 active site 272626000149 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272626000150 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272626000151 arginine deiminase; Provisional; Region: PRK01388 272626000152 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272626000153 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272626000154 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272626000155 dimer interface [polypeptide binding]; other site 272626000156 ssDNA binding site [nucleotide binding]; other site 272626000157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626000158 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272626000159 Predicted membrane protein [Function unknown]; Region: COG3212 272626000160 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272626000161 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272626000162 putative accessory gene regulator protein; Provisional; Region: PRK01100 272626000163 Staphylococcal AgrD protein; Region: AgrD; cl05477 272626000164 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272626000165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626000166 ATP binding site [chemical binding]; other site 272626000167 Mg2+ binding site [ion binding]; other site 272626000168 G-X-G motif; other site 272626000169 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272626000170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626000171 active site 272626000172 phosphorylation site [posttranslational modification] 272626000173 intermolecular recognition site; other site 272626000174 dimerization interface [polypeptide binding]; other site 272626000175 LytTr DNA-binding domain; Region: LytTR; pfam04397 272626000176 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272626000177 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272626000178 DHH family; Region: DHH; pfam01368 272626000179 DHHA1 domain; Region: DHHA1; pfam02272 272626000180 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272626000181 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272626000182 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272626000183 replicative DNA helicase; Provisional; Region: PRK05748 272626000184 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272626000185 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272626000186 Walker A motif; other site 272626000187 ATP binding site [chemical binding]; other site 272626000188 Walker B motif; other site 272626000189 DNA binding loops [nucleotide binding] 272626000190 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272626000191 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272626000192 GDP-binding site [chemical binding]; other site 272626000193 ACT binding site; other site 272626000194 IMP binding site; other site 272626000195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 272626000196 Predicted membrane protein [Function unknown]; Region: COG1511 272626000197 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272626000198 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 272626000199 Uncharacterized small protein [Function unknown]; Region: COG5417 272626000200 Predicted membrane protein [Function unknown]; Region: COG4499 272626000201 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 272626000202 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 272626000203 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 272626000204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272626000205 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272626000206 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 272626000207 Uncharacterized conserved protein [Function unknown]; Region: COG5444 272626000208 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 272626000210 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 272626000211 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272626000212 tetramer interface [polypeptide binding]; other site 272626000213 active site 272626000214 Mg2+/Mn2+ binding site [ion binding]; other site 272626000215 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272626000216 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272626000217 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272626000218 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272626000219 DNA binding site [nucleotide binding] 272626000220 active site 272626000221 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272626000222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 272626000223 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272626000224 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272626000225 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 272626000226 putative ligand binding site [chemical binding]; other site 272626000227 putative NAD binding site [chemical binding]; other site 272626000228 catalytic site [active] 272626000229 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626000230 Int/Topo IB signature motif; other site 272626000231 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626000232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626000233 non-specific DNA binding site [nucleotide binding]; other site 272626000234 salt bridge; other site 272626000235 sequence-specific DNA binding site [nucleotide binding]; other site 272626000236 Prophage antirepressor [Transcription]; Region: COG3617 272626000237 BRO family, N-terminal domain; Region: Bro-N; smart01040 272626000238 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 272626000239 Helix-turn-helix domain; Region: HTH_17; pfam12728 272626000240 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 272626000241 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 272626000242 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 272626000243 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272626000244 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272626000245 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272626000246 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 272626000247 phage uncharacterized protein TIGR01671; Region: phage_TIGR01671 272626000248 YopX protein; Region: YopX; pfam09643 272626000249 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272626000250 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272626000251 dimer interface [polypeptide binding]; other site 272626000252 ssDNA binding site [nucleotide binding]; other site 272626000253 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626000254 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 272626000255 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 272626000256 Protein of unknown function (DUF2481); Region: DUF2481; pfam10654 272626000257 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272626000258 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 272626000259 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 272626000260 Terminase-like family; Region: Terminase_6; pfam03237 272626000261 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 272626000262 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272626000263 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272626000264 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 272626000265 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 272626000266 Phage capsid family; Region: Phage_capsid; pfam05065 272626000267 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935 272626000268 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 272626000269 Minor capsid protein; Region: Minor_capsid_1; pfam10665 272626000270 Minor capsid protein; Region: Minor_capsid_2; pfam11114 272626000271 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 272626000272 highly similar to gp13 [Bacteriophage A118] (truncated, C-terminal end) 272626000273 Phage protein Gp14; Region: Phage_Gp14; pfam10666 272626000274 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 272626000275 tape measure domain; Region: tape_meas_nterm; TIGR02675 272626000276 Phage tail protein; Region: Sipho_tail; pfam05709 272626000277 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 272626000278 putative pectinesterase; Region: PLN02432; cl01911 272626000279 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272626000280 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 272626000281 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 272626000282 Phage holin; Region: Phage_holin_5; pfam06946 272626000283 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 272626000284 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272626000285 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000286 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272626000287 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 272626000288 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272626000289 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 272626000290 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 272626000291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272626000292 Walker A motif; other site 272626000293 ATP binding site [chemical binding]; other site 272626000294 Walker B motif; other site 272626000295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272626000296 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272626000297 core domain interface [polypeptide binding]; other site 272626000298 delta subunit interface [polypeptide binding]; other site 272626000299 epsilon subunit interface [polypeptide binding]; other site 272626000300 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272626000301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272626000302 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272626000303 alpha subunit interaction interface [polypeptide binding]; other site 272626000304 Walker A motif; other site 272626000305 ATP binding site [chemical binding]; other site 272626000306 Walker B motif; other site 272626000307 inhibitor binding site; inhibition site 272626000308 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272626000309 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 272626000310 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 272626000311 gamma subunit interface [polypeptide binding]; other site 272626000312 epsilon subunit interface [polypeptide binding]; other site 272626000313 LBP interface [polypeptide binding]; other site 272626000314 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000315 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000316 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000317 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000318 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000319 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000320 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626000321 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626000322 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000323 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272626000324 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626000325 active pocket/dimerization site; other site 272626000326 active site 272626000327 phosphorylation site [posttranslational modification] 272626000328 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272626000329 active site 272626000330 phosphorylation site [posttranslational modification] 272626000331 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272626000332 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272626000333 Domain of unknown function (DUF956); Region: DUF956; pfam06115 272626000334 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 272626000335 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272626000336 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 272626000337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626000338 dimerization interface [polypeptide binding]; other site 272626000339 putative DNA binding site [nucleotide binding]; other site 272626000340 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272626000341 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 272626000342 dimer interface [polypeptide binding]; other site 272626000343 FMN binding site [chemical binding]; other site 272626000344 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 272626000345 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 272626000346 active site 272626000347 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272626000348 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272626000349 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272626000350 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272626000351 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272626000352 AAA domain; Region: AAA_14; pfam13173 272626000353 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626000354 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626000355 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272626000356 Walker A/P-loop; other site 272626000357 ATP binding site [chemical binding]; other site 272626000358 Q-loop/lid; other site 272626000359 ABC transporter signature motif; other site 272626000360 Walker B; other site 272626000361 D-loop; other site 272626000362 H-loop/switch region; other site 272626000363 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626000364 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626000365 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272626000366 Walker A/P-loop; other site 272626000367 ATP binding site [chemical binding]; other site 272626000368 Q-loop/lid; other site 272626000369 ABC transporter signature motif; other site 272626000370 Walker B; other site 272626000371 D-loop; other site 272626000372 H-loop/switch region; other site 272626000373 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272626000374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626000375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626000376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626000377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272626000378 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272626000380 ligand binding site [chemical binding]; other site 272626000381 flexible hinge region; other site 272626000382 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272626000383 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272626000384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626000385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626000386 non-specific DNA binding site [nucleotide binding]; other site 272626000387 salt bridge; other site 272626000388 sequence-specific DNA binding site [nucleotide binding]; other site 272626000389 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272626000390 Predicted secreted protein [Function unknown]; Region: COG5437 272626000391 Phage-related protein [Function unknown]; Region: COG5412 272626000392 Phage tail protein; Region: Sipho_tail; pfam05709 272626000393 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 272626000394 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 272626000395 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272626000396 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272626000397 active site 272626000398 metal binding site [ion binding]; metal-binding site 272626000399 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272626000400 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 272626000401 putative active site [active] 272626000402 putative metal binding site [ion binding]; other site 272626000403 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272626000404 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272626000405 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 272626000406 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272626000407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 272626000408 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272626000409 active site 272626000410 Uncharacterized conserved protein [Function unknown]; Region: COG3592 272626000411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626000412 Coenzyme A binding pocket [chemical binding]; other site 272626000413 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272626000414 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272626000415 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272626000416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000417 dimer interface [polypeptide binding]; other site 272626000418 conserved gate region; other site 272626000419 putative PBP binding loops; other site 272626000420 ABC-ATPase subunit interface; other site 272626000421 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272626000422 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272626000423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000424 dimer interface [polypeptide binding]; other site 272626000425 conserved gate region; other site 272626000426 putative PBP binding loops; other site 272626000427 ABC-ATPase subunit interface; other site 272626000428 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 272626000429 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626000430 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 272626000431 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272626000432 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272626000433 peptide binding site [polypeptide binding]; other site 272626000434 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272626000435 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272626000436 metal binding site [ion binding]; metal-binding site 272626000437 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272626000438 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272626000439 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272626000440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626000441 ABC-ATPase subunit interface; other site 272626000442 dimer interface [polypeptide binding]; other site 272626000443 putative PBP binding regions; other site 272626000444 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000445 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626000446 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272626000447 DEAD_2; Region: DEAD_2; pfam06733 272626000448 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272626000449 sugar phosphate phosphatase; Provisional; Region: PRK10513 272626000450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000451 active site 272626000452 motif I; other site 272626000453 motif II; other site 272626000454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000455 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272626000456 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272626000457 active site 272626000458 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272626000459 NlpC/P60 family; Region: NLPC_P60; pfam00877 272626000460 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 272626000461 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272626000462 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272626000463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272626000464 peptide binding site [polypeptide binding]; other site 272626000465 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 272626000466 SxDxEG motif; other site 272626000467 active site 272626000468 metal binding site [ion binding]; metal-binding site 272626000469 homopentamer interface [polypeptide binding]; other site 272626000470 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272626000471 Collagen binding domain; Region: Collagen_bind; pfam05737 272626000472 Cna protein B-type domain; Region: Cna_B; pfam05738 272626000473 Cna protein B-type domain; Region: Cna_B; pfam05738 272626000474 Cna protein B-type domain; Region: Cna_B; pfam05738 272626000475 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626000476 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272626000477 Collagen binding domain; Region: Collagen_bind; pfam05737 272626000478 Cna protein B-type domain; Region: Cna_B; pfam05738 272626000479 Cna protein B-type domain; Region: Cna_B; pfam05738 272626000480 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626000481 DNA polymerase III subunit delta'; Validated; Region: PRK08058 272626000482 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272626000483 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 272626000484 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 272626000485 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272626000486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626000487 S-adenosylmethionine binding site [chemical binding]; other site 272626000488 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272626000489 GIY-YIG motif/motif A; other site 272626000490 putative active site [active] 272626000491 putative metal binding site [ion binding]; other site 272626000492 Predicted methyltransferases [General function prediction only]; Region: COG0313 272626000493 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272626000494 putative SAM binding site [chemical binding]; other site 272626000495 putative homodimer interface [polypeptide binding]; other site 272626000496 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 272626000497 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272626000498 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272626000499 Uncharacterized conserved protein [Function unknown]; Region: COG5361 272626000500 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 272626000501 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 272626000502 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626000503 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272626000504 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272626000505 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272626000506 active site 272626000507 HIGH motif; other site 272626000508 KMSKS motif; other site 272626000509 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272626000510 tRNA binding surface [nucleotide binding]; other site 272626000511 anticodon binding site; other site 272626000512 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272626000513 dimer interface [polypeptide binding]; other site 272626000514 putative tRNA-binding site [nucleotide binding]; other site 272626000515 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272626000516 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626000517 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626000518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272626000519 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272626000520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000521 dimer interface [polypeptide binding]; other site 272626000522 conserved gate region; other site 272626000523 putative PBP binding loops; other site 272626000524 ABC-ATPase subunit interface; other site 272626000525 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626000526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000527 dimer interface [polypeptide binding]; other site 272626000528 conserved gate region; other site 272626000529 putative PBP binding loops; other site 272626000530 ABC-ATPase subunit interface; other site 272626000531 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626000532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626000533 alpha-glucosidase; Provisional; Region: PRK10426 272626000534 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272626000535 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272626000536 active site 272626000537 catalytic site [active] 272626000538 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272626000539 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272626000540 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 272626000541 trimer interface [polypeptide binding]; other site 272626000542 active site 272626000543 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 272626000544 catalytic site [active] 272626000545 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272626000546 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272626000547 Ca binding site [ion binding]; other site 272626000548 active site 272626000549 catalytic site [active] 272626000550 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272626000551 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272626000552 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272626000553 active site 272626000554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 272626000555 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272626000556 Domain of unknown function (DUF348); Region: DUF348; pfam03990 272626000557 G5 domain; Region: G5; pfam07501 272626000558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272626000559 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272626000560 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272626000561 putative active site [active] 272626000562 putative metal binding site [ion binding]; other site 272626000563 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272626000564 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272626000565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626000566 S-adenosylmethionine binding site [chemical binding]; other site 272626000567 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 272626000568 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 272626000569 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272626000570 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 272626000571 putative active site [active] 272626000572 YdjC motif; other site 272626000573 Mg binding site [ion binding]; other site 272626000574 putative homodimer interface [polypeptide binding]; other site 272626000575 pur operon repressor; Provisional; Region: PRK09213 272626000576 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272626000577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626000578 active site 272626000579 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272626000580 HlyD family secretion protein; Region: HlyD_3; pfam13437 272626000581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626000582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626000583 Walker A/P-loop; other site 272626000584 ATP binding site [chemical binding]; other site 272626000585 Q-loop/lid; other site 272626000586 ABC transporter signature motif; other site 272626000587 Walker B; other site 272626000588 D-loop; other site 272626000589 H-loop/switch region; other site 272626000590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626000591 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272626000592 FtsX-like permease family; Region: FtsX; pfam02687 272626000593 regulatory protein SpoVG; Reviewed; Region: PRK13259 272626000594 regulatory protein SpoVG; Reviewed; Region: PRK13259 272626000595 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272626000596 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272626000597 Substrate binding site; other site 272626000598 Mg++ binding site; other site 272626000599 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272626000600 active site 272626000601 substrate binding site [chemical binding]; other site 272626000602 CoA binding site [chemical binding]; other site 272626000603 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272626000604 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272626000605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626000606 active site 272626000607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 272626000608 hypothetical protein; Provisional; Region: PRK01119 272626000609 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 272626000610 A new structural DNA glycosylase; Region: AlkD_like; cd06561 272626000611 active site 272626000612 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272626000613 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272626000614 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626000615 NAD binding site [chemical binding]; other site 272626000616 dimer interface [polypeptide binding]; other site 272626000617 substrate binding site [chemical binding]; other site 272626000618 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272626000619 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 272626000620 5S rRNA interface [nucleotide binding]; other site 272626000621 CTC domain interface [polypeptide binding]; other site 272626000622 L16 interface [polypeptide binding]; other site 272626000623 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272626000624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626000625 Coenzyme A binding pocket [chemical binding]; other site 272626000626 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272626000627 putative active site [active] 272626000628 catalytic residue [active] 272626000629 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272626000630 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272626000631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626000632 ATP binding site [chemical binding]; other site 272626000633 putative Mg++ binding site [ion binding]; other site 272626000634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626000635 nucleotide binding region [chemical binding]; other site 272626000636 ATP-binding site [chemical binding]; other site 272626000637 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272626000638 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272626000639 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272626000640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626000641 RNA binding surface [nucleotide binding]; other site 272626000642 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272626000643 Septum formation initiator; Region: DivIC; pfam04977 272626000644 hypothetical protein; Provisional; Region: PRK08582 272626000645 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 272626000646 RNA binding site [nucleotide binding]; other site 272626000647 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272626000648 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272626000649 Ligand Binding Site [chemical binding]; other site 272626000650 TilS substrate C-terminal domain; Region: TilS_C; smart00977 272626000651 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272626000652 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626000653 active site 272626000654 FtsH Extracellular; Region: FtsH_ext; pfam06480 272626000655 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272626000656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626000657 Walker A motif; other site 272626000658 ATP binding site [chemical binding]; other site 272626000659 Walker B motif; other site 272626000660 arginine finger; other site 272626000661 Peptidase family M41; Region: Peptidase_M41; pfam01434 272626000662 pantothenate kinase; Reviewed; Region: PRK13318 272626000663 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272626000664 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272626000665 dimerization interface [polypeptide binding]; other site 272626000666 domain crossover interface; other site 272626000667 redox-dependent activation switch; other site 272626000668 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272626000669 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272626000670 dimer interface [polypeptide binding]; other site 272626000671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626000672 catalytic residue [active] 272626000673 dihydropteroate synthase; Region: DHPS; TIGR01496 272626000674 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272626000675 substrate binding pocket [chemical binding]; other site 272626000676 dimer interface [polypeptide binding]; other site 272626000677 inhibitor binding site; inhibition site 272626000678 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272626000679 homooctamer interface [polypeptide binding]; other site 272626000680 active site 272626000681 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272626000682 catalytic center binding site [active] 272626000683 ATP binding site [chemical binding]; other site 272626000684 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272626000685 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272626000686 FMN binding site [chemical binding]; other site 272626000687 active site 272626000688 catalytic residues [active] 272626000689 substrate binding site [chemical binding]; other site 272626000690 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272626000691 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272626000692 dimer interface [polypeptide binding]; other site 272626000693 putative anticodon binding site; other site 272626000694 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272626000695 motif 1; other site 272626000696 active site 272626000697 motif 2; other site 272626000698 motif 3; other site 272626000699 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 272626000700 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 272626000701 UvrB/uvrC motif; Region: UVR; pfam02151 272626000702 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 272626000703 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 272626000704 ADP binding site [chemical binding]; other site 272626000705 phosphagen binding site; other site 272626000706 substrate specificity loop; other site 272626000707 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272626000708 Clp amino terminal domain; Region: Clp_N; pfam02861 272626000709 Clp amino terminal domain; Region: Clp_N; pfam02861 272626000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626000711 Walker A motif; other site 272626000712 ATP binding site [chemical binding]; other site 272626000713 Walker B motif; other site 272626000714 arginine finger; other site 272626000715 UvrB/uvrC motif; Region: UVR; pfam02151 272626000716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626000717 Walker A motif; other site 272626000718 ATP binding site [chemical binding]; other site 272626000719 Walker B motif; other site 272626000720 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272626000721 DNA repair protein RadA; Provisional; Region: PRK11823 272626000722 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272626000723 Walker A motif/ATP binding site; other site 272626000724 ATP binding site [chemical binding]; other site 272626000725 Walker B motif; other site 272626000726 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272626000727 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 272626000728 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 272626000729 putative active site [active] 272626000730 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272626000731 substrate binding site; other site 272626000732 dimer interface; other site 272626000733 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272626000734 homotrimer interaction site [polypeptide binding]; other site 272626000735 zinc binding site [ion binding]; other site 272626000736 CDP-binding sites; other site 272626000737 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272626000738 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272626000739 HIGH motif; other site 272626000740 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272626000741 active site 272626000742 KMSKS motif; other site 272626000743 serine O-acetyltransferase; Region: cysE; TIGR01172 272626000744 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272626000745 trimer interface [polypeptide binding]; other site 272626000746 active site 272626000747 substrate binding site [chemical binding]; other site 272626000748 CoA binding site [chemical binding]; other site 272626000749 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272626000750 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272626000751 active site 272626000752 HIGH motif; other site 272626000753 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272626000754 KMSKS motif; other site 272626000755 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 272626000756 tRNA binding surface [nucleotide binding]; other site 272626000757 anticodon binding site; other site 272626000758 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272626000759 active site 272626000760 metal binding site [ion binding]; metal-binding site 272626000761 dimerization interface [polypeptide binding]; other site 272626000762 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272626000763 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272626000764 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272626000765 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 272626000766 RNA polymerase factor sigma-70; Validated; Region: PRK08295 272626000767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272626000768 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 272626000769 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272626000770 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 272626000771 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272626000772 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272626000773 putative homodimer interface [polypeptide binding]; other site 272626000774 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272626000775 heterodimer interface [polypeptide binding]; other site 272626000776 homodimer interface [polypeptide binding]; other site 272626000777 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272626000778 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272626000779 23S rRNA interface [nucleotide binding]; other site 272626000780 L7/L12 interface [polypeptide binding]; other site 272626000781 putative thiostrepton binding site; other site 272626000782 L25 interface [polypeptide binding]; other site 272626000783 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272626000784 mRNA/rRNA interface [nucleotide binding]; other site 272626000785 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272626000786 23S rRNA interface [nucleotide binding]; other site 272626000787 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272626000788 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272626000789 core dimer interface [polypeptide binding]; other site 272626000790 peripheral dimer interface [polypeptide binding]; other site 272626000791 L10 interface [polypeptide binding]; other site 272626000792 L11 interface [polypeptide binding]; other site 272626000793 putative EF-Tu interaction site [polypeptide binding]; other site 272626000794 putative EF-G interaction site [polypeptide binding]; other site 272626000795 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272626000796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626000797 S-adenosylmethionine binding site [chemical binding]; other site 272626000798 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272626000799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272626000800 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272626000801 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272626000802 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272626000803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272626000804 RPB10 interaction site [polypeptide binding]; other site 272626000805 RPB1 interaction site [polypeptide binding]; other site 272626000806 RPB11 interaction site [polypeptide binding]; other site 272626000807 RPB3 interaction site [polypeptide binding]; other site 272626000808 RPB12 interaction site [polypeptide binding]; other site 272626000809 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272626000810 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272626000811 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272626000812 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272626000813 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272626000814 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272626000815 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272626000816 G-loop; other site 272626000817 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272626000818 DNA binding site [nucleotide binding] 272626000819 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272626000820 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 272626000821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000822 active site 272626000823 motif I; other site 272626000824 motif II; other site 272626000825 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626000826 beta-galactosidase; Region: BGL; TIGR03356 272626000827 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 272626000828 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 272626000829 metal binding site [ion binding]; metal-binding site 272626000830 dimer interface [polypeptide binding]; other site 272626000831 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626000832 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626000833 LRR adjacent; Region: LRR_adjacent; pfam08191 272626000834 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626000835 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626000836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626000837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626000838 putative Zn2+ binding site [ion binding]; other site 272626000839 putative DNA binding site [nucleotide binding]; other site 272626000840 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272626000841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626000842 Zn binding site [ion binding]; other site 272626000843 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272626000844 Zn binding site [ion binding]; other site 272626000845 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626000846 catalytic core [active] 272626000847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272626000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000849 dimer interface [polypeptide binding]; other site 272626000850 conserved gate region; other site 272626000851 putative PBP binding loops; other site 272626000852 ABC-ATPase subunit interface; other site 272626000853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272626000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000855 dimer interface [polypeptide binding]; other site 272626000856 conserved gate region; other site 272626000857 ABC-ATPase subunit interface; other site 272626000858 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626000859 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272626000860 Leucine-rich repeats; other site 272626000861 Substrate binding site [chemical binding]; other site 272626000862 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 272626000863 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626000864 beta-galactosidase; Region: BGL; TIGR03356 272626000865 sugar phosphate phosphatase; Provisional; Region: PRK10513 272626000866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000867 active site 272626000868 motif I; other site 272626000869 motif II; other site 272626000870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626000872 Coenzyme A binding pocket [chemical binding]; other site 272626000873 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000874 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272626000875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272626000876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000877 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272626000878 active site 272626000879 motif I; other site 272626000880 motif II; other site 272626000881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626000882 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626000883 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626000884 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272626000885 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272626000886 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272626000887 Walker A/P-loop; other site 272626000888 ATP binding site [chemical binding]; other site 272626000889 Q-loop/lid; other site 272626000890 ABC transporter signature motif; other site 272626000891 Walker B; other site 272626000892 D-loop; other site 272626000893 H-loop/switch region; other site 272626000894 TOBE domain; Region: TOBE; pfam03459 272626000895 ATP cone domain; Region: ATP-cone; pfam03477 272626000896 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272626000897 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272626000898 effector binding site; other site 272626000899 active site 272626000900 Zn binding site [ion binding]; other site 272626000901 glycine loop; other site 272626000902 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 272626000903 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 272626000904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626000905 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272626000906 Walker A/P-loop; other site 272626000907 ATP binding site [chemical binding]; other site 272626000908 Q-loop/lid; other site 272626000909 ABC transporter signature motif; other site 272626000910 Walker B; other site 272626000911 D-loop; other site 272626000912 H-loop/switch region; other site 272626000913 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626000914 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626000915 ligand binding site [chemical binding]; other site 272626000916 flexible hinge region; other site 272626000917 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272626000918 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 272626000919 putative active site [active] 272626000920 catalytic triad [active] 272626000921 putative dimer interface [polypeptide binding]; other site 272626000922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626000923 dimer interface [polypeptide binding]; other site 272626000924 conserved gate region; other site 272626000925 ABC-ATPase subunit interface; other site 272626000926 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272626000927 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272626000928 Walker A/P-loop; other site 272626000929 ATP binding site [chemical binding]; other site 272626000930 Q-loop/lid; other site 272626000931 ABC transporter signature motif; other site 272626000932 Walker B; other site 272626000933 D-loop; other site 272626000934 H-loop/switch region; other site 272626000935 NIL domain; Region: NIL; pfam09383 272626000936 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272626000937 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272626000938 transaminase; Reviewed; Region: PRK08068 272626000939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626000940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626000941 homodimer interface [polypeptide binding]; other site 272626000942 catalytic residue [active] 272626000943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626000944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626000945 active site 272626000946 phosphorylation site [posttranslational modification] 272626000947 intermolecular recognition site; other site 272626000948 dimerization interface [polypeptide binding]; other site 272626000949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626000950 DNA binding site [nucleotide binding] 272626000951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272626000952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626000953 dimerization interface [polypeptide binding]; other site 272626000954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272626000955 putative active site [active] 272626000956 heme pocket [chemical binding]; other site 272626000957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626000958 dimer interface [polypeptide binding]; other site 272626000959 phosphorylation site [posttranslational modification] 272626000960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626000961 ATP binding site [chemical binding]; other site 272626000962 Mg2+ binding site [ion binding]; other site 272626000963 G-X-G motif; other site 272626000964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 272626000965 YycH protein; Region: YycH; pfam07435 272626000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 272626000967 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272626000968 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272626000969 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272626000970 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272626000971 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272626000972 protein binding site [polypeptide binding]; other site 272626000973 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272626000974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626000975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626000976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272626000977 dimerization interface [polypeptide binding]; other site 272626000978 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272626000979 dimer interface [polypeptide binding]; other site 272626000980 FMN binding site [chemical binding]; other site 272626000981 NADPH bind site [chemical binding]; other site 272626000982 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626000983 HTH domain; Region: HTH_11; pfam08279 272626000984 Mga helix-turn-helix domain; Region: Mga; pfam05043 272626000985 PRD domain; Region: PRD; pfam00874 272626000986 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626000987 active site 272626000988 P-loop; other site 272626000989 phosphorylation site [posttranslational modification] 272626000990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626000991 active site 272626000992 phosphorylation site [posttranslational modification] 272626000993 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626000994 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626000995 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626000996 active site 272626000997 P-loop; other site 272626000998 phosphorylation site [posttranslational modification] 272626000999 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626001000 beta-galactosidase; Region: BGL; TIGR03356 272626001001 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626001002 methionine cluster; other site 272626001003 active site 272626001004 phosphorylation site [posttranslational modification] 272626001005 metal binding site [ion binding]; metal-binding site 272626001006 H+ Antiporter protein; Region: 2A0121; TIGR00900 272626001007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 272626001008 putative substrate translocation pore; other site 272626001009 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272626001010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272626001011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626001012 catalytic residue [active] 272626001013 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 272626001014 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272626001015 nucleophilic elbow; other site 272626001016 catalytic triad; other site 272626001017 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272626001018 Protein of unknown function DUF262; Region: DUF262; pfam03235 272626001019 Protein of unknown function DUF262; Region: DUF262; pfam03235 272626001020 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 272626001021 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 272626001022 putative active site [active] 272626001023 YdjC motif; other site 272626001024 Mg binding site [ion binding]; other site 272626001025 putative homodimer interface [polypeptide binding]; other site 272626001026 Putative transcription activator [Transcription]; Region: TenA; COG0819 272626001027 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272626001028 substrate binding site [chemical binding]; other site 272626001029 multimerization interface [polypeptide binding]; other site 272626001030 ATP binding site [chemical binding]; other site 272626001031 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272626001032 dimer interface [polypeptide binding]; other site 272626001033 substrate binding site [chemical binding]; other site 272626001034 ATP binding site [chemical binding]; other site 272626001035 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272626001036 thiamine phosphate binding site [chemical binding]; other site 272626001037 active site 272626001038 pyrophosphate binding site [ion binding]; other site 272626001039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626001040 beta-galactosidase; Region: BGL; TIGR03356 272626001041 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 272626001042 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 272626001043 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 272626001044 putative catalytic site [active] 272626001045 putative metal binding site [ion binding]; other site 272626001046 putative phosphate binding site [ion binding]; other site 272626001047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626001048 non-specific DNA binding site [nucleotide binding]; other site 272626001049 salt bridge; other site 272626001050 sequence-specific DNA binding site [nucleotide binding]; other site 272626001051 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272626001052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626001053 non-specific DNA binding site [nucleotide binding]; other site 272626001054 salt bridge; other site 272626001055 sequence-specific DNA binding site [nucleotide binding]; other site 272626001056 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272626001057 Leucine rich repeat; Region: LRR_8; pfam13855 272626001058 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001059 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001060 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001061 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001062 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001063 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001064 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001067 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001068 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001069 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001070 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001071 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001072 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272626001073 Substrate binding site [chemical binding]; other site 272626001074 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626001075 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626001076 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626001077 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 272626001078 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626001079 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 272626001080 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272626001081 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272626001082 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272626001083 TPP-binding site [chemical binding]; other site 272626001084 dimer interface [polypeptide binding]; other site 272626001085 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272626001086 PYR/PP interface [polypeptide binding]; other site 272626001087 dimer interface [polypeptide binding]; other site 272626001088 TPP binding site [chemical binding]; other site 272626001089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272626001090 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272626001091 active site 272626001092 intersubunit interactions; other site 272626001093 catalytic residue [active] 272626001094 short chain dehydrogenase; Provisional; Region: PRK06841 272626001095 classical (c) SDRs; Region: SDR_c; cd05233 272626001096 NAD(P) binding site [chemical binding]; other site 272626001097 active site 272626001098 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 272626001099 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272626001100 substrate binding site [chemical binding]; other site 272626001101 dimer interface [polypeptide binding]; other site 272626001102 catalytic triad [active] 272626001103 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272626001104 DAK2 domain; Region: Dak2; cl03685 272626001105 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 272626001106 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272626001107 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272626001108 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 272626001109 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626001110 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626001111 putative DNA binding site [nucleotide binding]; other site 272626001112 putative Zn2+ binding site [ion binding]; other site 272626001113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626001114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626001115 Coenzyme A binding pocket [chemical binding]; other site 272626001116 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626001117 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626001118 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272626001119 Leucine-rich repeats; other site 272626001120 Substrate binding site [chemical binding]; other site 272626001121 LRR adjacent; Region: LRR_adjacent; pfam08191 272626001122 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626001123 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626001124 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626001125 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272626001126 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272626001127 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272626001128 acyl-activating enzyme (AAE) consensus motif; other site 272626001129 acyl-activating enzyme (AAE) consensus motif; other site 272626001130 AMP binding site [chemical binding]; other site 272626001131 active site 272626001132 CoA binding site [chemical binding]; other site 272626001133 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 272626001134 L-aspartate oxidase; Provisional; Region: PRK06175 272626001135 putative oxidoreductase; Provisional; Region: PRK10206 272626001136 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626001137 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272626001138 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001139 active site 272626001140 phosphorylation site [posttranslational modification] 272626001141 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 272626001142 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272626001143 active site 272626001144 P-loop; other site 272626001145 phosphorylation site [posttranslational modification] 272626001146 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272626001147 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272626001148 intersubunit interface [polypeptide binding]; other site 272626001149 active site 272626001150 zinc binding site [ion binding]; other site 272626001151 Na+ binding site [ion binding]; other site 272626001152 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626001153 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272626001154 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626001155 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 272626001156 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 272626001157 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 272626001158 catalytic triad [active] 272626001159 active site nucleophile [active] 272626001160 Predicted transcriptional regulator [Transcription]; Region: COG2378 272626001161 HTH domain; Region: HTH_11; pfam08279 272626001162 WYL domain; Region: WYL; pfam13280 272626001163 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 272626001164 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 272626001165 Imelysin; Region: Peptidase_M75; pfam09375 272626001166 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 272626001167 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 272626001168 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 272626001169 nudix motif; other site 272626001170 hypothetical protein; Provisional; Region: PRK12378 272626001171 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272626001172 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272626001173 PhnA protein; Region: PhnA; pfam03831 272626001174 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626001175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626001176 DNA-binding site [nucleotide binding]; DNA binding site 272626001177 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272626001178 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626001179 beta-galactosidase; Region: BGL; TIGR03356 272626001180 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626001181 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272626001182 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626001183 active site 272626001184 P-loop; other site 272626001185 phosphorylation site [posttranslational modification] 272626001186 Predicted transcriptional regulator [Transcription]; Region: COG2378 272626001187 HTH domain; Region: HTH_11; pfam08279 272626001188 WYL domain; Region: WYL; pfam13280 272626001189 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 272626001190 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626001191 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626001192 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272626001193 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626001194 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272626001195 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 272626001196 tetrameric interface [polypeptide binding]; other site 272626001197 NAD binding site [chemical binding]; other site 272626001198 catalytic residues [active] 272626001199 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 272626001200 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272626001201 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272626001202 substrate binding site [chemical binding]; other site 272626001203 ATP binding site [chemical binding]; other site 272626001204 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272626001205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272626001206 PYR/PP interface [polypeptide binding]; other site 272626001207 dimer interface [polypeptide binding]; other site 272626001208 TPP binding site [chemical binding]; other site 272626001209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272626001210 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 272626001211 TPP-binding site; other site 272626001212 Uncharacterized conserved protein [Function unknown]; Region: COG5646 272626001213 Predicted membrane protein [Function unknown]; Region: COG4292 272626001214 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272626001215 ligand binding site [chemical binding]; other site 272626001216 active site 272626001217 UGI interface [polypeptide binding]; other site 272626001218 catalytic site [active] 272626001219 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 272626001220 hypothetical protein; Provisional; Region: PRK13665 272626001221 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 272626001222 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626001223 NlpC/P60 family; Region: NLPC_P60; pfam00877 272626001224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626001225 Coenzyme A binding pocket [chemical binding]; other site 272626001226 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272626001227 pyrroline-5-carboxylate reductase; Region: PLN02688 272626001228 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626001229 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626001230 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626001231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272626001232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626001233 DNA-binding site [nucleotide binding]; DNA binding site 272626001234 HlyD family secretion protein; Region: HlyD_3; pfam13437 272626001235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626001236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626001237 Walker A/P-loop; other site 272626001238 ATP binding site [chemical binding]; other site 272626001239 Q-loop/lid; other site 272626001240 ABC transporter signature motif; other site 272626001241 Walker B; other site 272626001242 D-loop; other site 272626001243 H-loop/switch region; other site 272626001244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626001245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272626001246 FtsX-like permease family; Region: FtsX; pfam02687 272626001247 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 272626001248 putative hydrophobic ligand binding site [chemical binding]; other site 272626001249 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001250 active site 272626001251 phosphorylation site [posttranslational modification] 272626001252 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272626001253 active site 272626001254 P-loop; other site 272626001255 phosphorylation site [posttranslational modification] 272626001256 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272626001257 alpha-mannosidase; Provisional; Region: PRK09819 272626001258 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 272626001259 active site 272626001260 metal binding site [ion binding]; metal-binding site 272626001261 catalytic site [active] 272626001262 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272626001263 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626001264 HTH domain; Region: HTH_11; pfam08279 272626001265 Mga helix-turn-helix domain; Region: Mga; pfam05043 272626001266 PRD domain; Region: PRD; pfam00874 272626001267 PRD domain; Region: PRD; pfam00874 272626001268 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626001269 active site 272626001270 P-loop; other site 272626001271 phosphorylation site [posttranslational modification] 272626001272 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001273 active site 272626001274 phosphorylation site [posttranslational modification] 272626001275 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272626001276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 272626001277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626001278 putative metal binding site [ion binding]; other site 272626001279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 272626001280 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 272626001281 trimer interface [polypeptide binding]; other site 272626001282 phosphoenolpyruvate synthase; Validated; Region: PRK06241 272626001283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272626001284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272626001285 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 272626001286 ZIP Zinc transporter; Region: Zip; pfam02535 272626001287 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272626001288 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 272626001289 NodB motif; other site 272626001290 active site 272626001291 catalytic site [active] 272626001292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626001293 non-specific DNA binding site [nucleotide binding]; other site 272626001294 salt bridge; other site 272626001295 sequence-specific DNA binding site [nucleotide binding]; other site 272626001296 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626001297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001298 active site 272626001299 motif I; other site 272626001300 motif II; other site 272626001301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001302 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272626001303 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 272626001304 Predicted transcriptional regulators [Transcription]; Region: COG1695 272626001305 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 272626001306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272626001307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272626001308 DNA binding residues [nucleotide binding] 272626001309 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272626001310 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626001311 HTH domain; Region: HTH_11; pfam08279 272626001312 PRD domain; Region: PRD; pfam00874 272626001313 PRD domain; Region: PRD; pfam00874 272626001314 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626001315 active site 272626001316 P-loop; other site 272626001317 phosphorylation site [posttranslational modification] 272626001318 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001319 active site 272626001320 phosphorylation site [posttranslational modification] 272626001321 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001322 active site 272626001323 phosphorylation site [posttranslational modification] 272626001324 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272626001325 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272626001326 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 272626001327 active site 272626001328 metal binding site [ion binding]; metal-binding site 272626001329 catalytic site [active] 272626001330 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 272626001331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626001332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626001333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272626001334 dimerization interface [polypeptide binding]; other site 272626001335 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272626001336 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272626001337 active site 272626001338 substrate binding site [chemical binding]; other site 272626001339 trimer interface [polypeptide binding]; other site 272626001340 CoA binding site [chemical binding]; other site 272626001341 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272626001342 classical (c) SDRs; Region: SDR_c; cd05233 272626001343 NAD(P) binding site [chemical binding]; other site 272626001344 active site 272626001345 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 272626001346 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 272626001347 RHS Repeat; Region: RHS_repeat; pfam05593 272626001348 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 272626001349 RHS Repeat; Region: RHS_repeat; pfam05593 272626001350 RHS Repeat; Region: RHS_repeat; pfam05593 272626001351 RHS Repeat; Region: RHS_repeat; pfam05593 272626001352 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 272626001353 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 272626001354 Predicted transcriptional regulator [Transcription]; Region: COG1959 272626001355 Transcriptional regulator; Region: Rrf2; pfam02082 272626001356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626001357 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272626001358 NAD(P) binding site [chemical binding]; other site 272626001359 active site 272626001360 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 272626001361 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 272626001362 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272626001363 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272626001364 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272626001365 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272626001366 Predicted transcriptional regulator [Transcription]; Region: COG2378 272626001367 HTH domain; Region: HTH_11; pfam08279 272626001368 WYL domain; Region: WYL; pfam13280 272626001369 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 272626001370 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272626001371 conserved cys residue [active] 272626001372 Predicted membrane protein [Function unknown]; Region: COG3619 272626001373 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272626001374 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272626001375 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 272626001376 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 272626001377 Protein of unknown function DUF58; Region: DUF58; pfam01882 272626001378 MoxR-like ATPases [General function prediction only]; Region: COG0714 272626001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626001380 Walker A motif; other site 272626001381 ATP binding site [chemical binding]; other site 272626001382 Walker B motif; other site 272626001383 arginine finger; other site 272626001384 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272626001385 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272626001386 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 272626001387 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 272626001388 Na binding site [ion binding]; other site 272626001389 Uncharacterized conserved protein [Function unknown]; Region: COG3535 272626001390 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 272626001391 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626001392 nucleotide binding site [chemical binding]; other site 272626001393 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 272626001394 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272626001395 P-loop containing region of AAA domain; Region: AAA_29; cl17516 272626001396 AAA domain; Region: AAA_21; pfam13304 272626001397 AAA domain; Region: AAA_21; pfam13304 272626001398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626001399 ABC transporter signature motif; other site 272626001400 Walker B; other site 272626001401 D-loop; other site 272626001402 H-loop/switch region; other site 272626001403 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 272626001405 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 272626001406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626001407 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 272626001408 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 272626001409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272626001410 FeS/SAM binding site; other site 272626001411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272626001412 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272626001413 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 272626001414 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272626001415 putative FMN binding site [chemical binding]; other site 272626001416 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 272626001417 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 272626001418 nudix motif; other site 272626001419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626001420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626001421 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272626001422 putative dimerization interface [polypeptide binding]; other site 272626001423 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272626001424 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272626001425 active site 272626001426 FMN binding site [chemical binding]; other site 272626001427 substrate binding site [chemical binding]; other site 272626001428 putative catalytic residue [active] 272626001429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272626001430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626001431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626001432 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 272626001433 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272626001434 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272626001435 shikimate binding site; other site 272626001436 NAD(P) binding site [chemical binding]; other site 272626001437 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 272626001438 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272626001439 active site 272626001440 catalytic residue [active] 272626001441 dimer interface [polypeptide binding]; other site 272626001442 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 272626001443 active site 272626001444 catalytic triad [active] 272626001445 oxyanion hole [active] 272626001446 EamA-like transporter family; Region: EamA; pfam00892 272626001447 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272626001448 EamA-like transporter family; Region: EamA; pfam00892 272626001449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272626001450 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 272626001451 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272626001452 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272626001453 substrate binding site [chemical binding]; other site 272626001454 hexamer interface [polypeptide binding]; other site 272626001455 metal binding site [ion binding]; metal-binding site 272626001456 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 272626001457 catalytic residue [active] 272626001458 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626001459 PRD domain; Region: PRD; pfam00874 272626001460 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626001461 active site 272626001462 P-loop; other site 272626001463 phosphorylation site [posttranslational modification] 272626001464 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001465 active site 272626001466 phosphorylation site [posttranslational modification] 272626001467 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272626001468 putative active site [active] 272626001469 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626001470 active site 272626001471 phosphorylation site [posttranslational modification] 272626001472 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272626001473 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272626001474 substrate binding site [chemical binding]; other site 272626001475 hexamer interface [polypeptide binding]; other site 272626001476 metal binding site [ion binding]; metal-binding site 272626001477 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272626001478 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 272626001479 putative NAD(P) binding site [chemical binding]; other site 272626001480 catalytic Zn binding site [ion binding]; other site 272626001481 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 272626001482 active site 272626001483 P-loop; other site 272626001484 phosphorylation site [posttranslational modification] 272626001485 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 272626001486 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272626001487 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272626001488 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272626001489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626001490 active site 272626001491 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 272626001492 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272626001493 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272626001494 catalytic triad [active] 272626001495 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 272626001496 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626001497 MarR family; Region: MarR_2; pfam12802 272626001498 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626001499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272626001500 Ligand Binding Site [chemical binding]; other site 272626001501 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 272626001502 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 272626001503 putative active site [active] 272626001504 putative metal binding site [ion binding]; other site 272626001505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001506 catalytic core [active] 272626001507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001508 Predicted membrane protein [Function unknown]; Region: COG3759 272626001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626001510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626001511 putative substrate translocation pore; other site 272626001512 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272626001513 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626001514 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272626001515 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272626001516 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272626001517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626001518 ATP binding site [chemical binding]; other site 272626001519 putative Mg++ binding site [ion binding]; other site 272626001520 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272626001521 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 272626001522 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272626001523 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272626001524 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272626001525 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272626001526 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272626001527 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626001528 Int/Topo IB signature motif; other site 272626001529 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272626001530 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272626001531 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272626001532 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272626001533 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272626001534 NAD binding site [chemical binding]; other site 272626001535 sugar binding site [chemical binding]; other site 272626001536 divalent metal binding site [ion binding]; other site 272626001537 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626001538 dimer interface [polypeptide binding]; other site 272626001539 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272626001540 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272626001541 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626001542 putative active site [active] 272626001543 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272626001544 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272626001545 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272626001546 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272626001547 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272626001548 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272626001549 DNA binding residues [nucleotide binding] 272626001550 dimer interface [polypeptide binding]; other site 272626001551 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272626001552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298 272626001553 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272626001554 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272626001555 DXD motif; other site 272626001556 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 272626001557 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 272626001558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272626001559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626001560 S-adenosylmethionine binding site [chemical binding]; other site 272626001561 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 272626001562 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 272626001563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626001564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626001565 DNA binding site [nucleotide binding] 272626001566 domain linker motif; other site 272626001567 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 272626001568 putative dimerization interface [polypeptide binding]; other site 272626001569 putative ligand binding site [chemical binding]; other site 272626001570 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272626001571 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272626001572 NAD binding site [chemical binding]; other site 272626001573 sugar binding site [chemical binding]; other site 272626001574 divalent metal binding site [ion binding]; other site 272626001575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626001576 dimer interface [polypeptide binding]; other site 272626001577 allantoate amidohydrolase; Reviewed; Region: PRK09290 272626001578 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272626001579 active site 272626001580 metal binding site [ion binding]; metal-binding site 272626001581 dimer interface [polypeptide binding]; other site 272626001582 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272626001583 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 272626001584 metal binding site [ion binding]; metal-binding site 272626001585 putative dimer interface [polypeptide binding]; other site 272626001586 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 272626001587 Beta-lactamase; Region: Beta-lactamase; pfam00144 272626001588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272626001589 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272626001590 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272626001591 putative ligand binding residues [chemical binding]; other site 272626001592 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 272626001593 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 272626001594 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 272626001595 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 272626001596 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 272626001597 Glucitol operon activator protein (GutM); Region: GutM; cl01890 272626001598 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 272626001599 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 272626001600 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272626001601 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272626001602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626001603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272626001604 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626001605 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626001606 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272626001607 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626001608 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272626001609 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272626001610 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272626001611 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626001612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272626001613 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272626001614 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626001615 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272626001616 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272626001617 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272626001618 FOG: CBS domain [General function prediction only]; Region: COG0517 272626001619 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272626001620 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 272626001621 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272626001622 dimer interface [polypeptide binding]; other site 272626001623 active site 272626001624 metal binding site [ion binding]; metal-binding site 272626001625 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272626001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626001627 putative substrate translocation pore; other site 272626001628 POT family; Region: PTR2; pfam00854 272626001629 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001630 catalytic core [active] 272626001631 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001632 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001633 catalytic core [active] 272626001634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626001635 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 272626001636 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272626001637 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272626001638 Cl binding site [ion binding]; other site 272626001639 oligomer interface [polypeptide binding]; other site 272626001640 glutamate dehydrogenase; Provisional; Region: PRK09414 272626001641 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 272626001642 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 272626001643 NAD(P) binding site [chemical binding]; other site 272626001644 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272626001645 metal binding site [ion binding]; metal-binding site 272626001646 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 272626001647 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272626001648 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272626001649 substrate binding site [chemical binding]; other site 272626001650 glutamase interaction surface [polypeptide binding]; other site 272626001651 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272626001652 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272626001653 catalytic residues [active] 272626001654 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 272626001655 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272626001656 putative active site [active] 272626001657 oxyanion strand; other site 272626001658 catalytic triad [active] 272626001659 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272626001660 putative active site pocket [active] 272626001661 4-fold oligomerization interface [polypeptide binding]; other site 272626001662 metal binding residues [ion binding]; metal-binding site 272626001663 3-fold/trimer interface [polypeptide binding]; other site 272626001664 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272626001665 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272626001666 NAD binding site [chemical binding]; other site 272626001667 dimerization interface [polypeptide binding]; other site 272626001668 product binding site; other site 272626001669 substrate binding site [chemical binding]; other site 272626001670 zinc binding site [ion binding]; other site 272626001671 catalytic residues [active] 272626001672 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 272626001673 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 272626001674 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 272626001675 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272626001676 dimer interface [polypeptide binding]; other site 272626001677 motif 1; other site 272626001678 active site 272626001679 motif 2; other site 272626001680 motif 3; other site 272626001681 histidinol-phosphatase; Reviewed; Region: PRK08123 272626001682 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 272626001683 active site 272626001684 dimer interface [polypeptide binding]; other site 272626001685 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272626001686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272626001687 DNA binding site [nucleotide binding] 272626001688 active site 272626001689 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 272626001690 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272626001691 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626001692 beta-galactosidase; Region: BGL; TIGR03356 272626001693 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626001694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626001695 DNA-binding site [nucleotide binding]; DNA binding site 272626001696 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272626001697 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001698 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626001699 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 272626001700 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272626001701 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272626001702 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 272626001703 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 272626001704 Predicted esterase [General function prediction only]; Region: COG0400 272626001705 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272626001706 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272626001707 putative RNA binding site [nucleotide binding]; other site 272626001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626001709 S-adenosylmethionine binding site [chemical binding]; other site 272626001710 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 272626001711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626001712 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626001713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626001714 NlpC/P60 family; Region: NLPC_P60; pfam00877 272626001715 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 272626001716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272626001717 ATP binding site [chemical binding]; other site 272626001718 putative Mg++ binding site [ion binding]; other site 272626001719 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272626001720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 272626001721 nucleotide binding region [chemical binding]; other site 272626001722 ATP-binding site [chemical binding]; other site 272626001723 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272626001724 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272626001725 WxL domain surface cell wall-binding; Region: WxL; pfam13731 272626001726 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272626001727 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272626001728 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 272626001729 DNA photolyase; Region: DNA_photolyase; pfam00875 272626001730 Predicted membrane protein [Function unknown]; Region: COG4852 272626001731 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272626001732 DAK2 domain; Region: Dak2; pfam02734 272626001733 EDD domain protein, DegV family; Region: DegV; TIGR00762 272626001734 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272626001735 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 272626001736 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272626001737 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 272626001738 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 272626001739 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 272626001740 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272626001741 homodimer interface [polypeptide binding]; other site 272626001742 substrate-cofactor binding pocket; other site 272626001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626001744 catalytic residue [active] 272626001745 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272626001746 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626001747 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272626001748 ligand binding site [chemical binding]; other site 272626001749 flexible hinge region; other site 272626001750 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272626001751 non-specific DNA interactions [nucleotide binding]; other site 272626001752 DNA binding site [nucleotide binding] 272626001753 sequence specific DNA binding site [nucleotide binding]; other site 272626001754 putative cAMP binding site [chemical binding]; other site 272626001755 BioY family; Region: BioY; pfam02632 272626001756 Predicted transcriptional regulators [Transcription]; Region: COG1695 272626001757 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272626001758 Predicted membrane protein [Function unknown]; Region: COG4709 272626001759 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272626001760 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272626001761 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272626001762 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272626001763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272626001764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626001765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626001766 Coenzyme A binding pocket [chemical binding]; other site 272626001767 Tic20-like protein; Region: Tic20; pfam09685 272626001768 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 272626001769 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272626001770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626001771 MarR family; Region: MarR_2; pfam12802 272626001772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626001773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626001774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626001775 Walker A/P-loop; other site 272626001776 ATP binding site [chemical binding]; other site 272626001777 Q-loop/lid; other site 272626001778 ABC transporter signature motif; other site 272626001779 Walker B; other site 272626001780 D-loop; other site 272626001781 H-loop/switch region; other site 272626001782 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626001783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626001784 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272626001785 Walker A/P-loop; other site 272626001786 ATP binding site [chemical binding]; other site 272626001787 Q-loop/lid; other site 272626001788 ABC transporter signature motif; other site 272626001789 Walker B; other site 272626001790 D-loop; other site 272626001791 H-loop/switch region; other site 272626001792 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272626001793 active site residue [active] 272626001794 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626001795 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272626001796 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272626001797 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626001798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626001799 putative DNA binding site [nucleotide binding]; other site 272626001800 putative Zn2+ binding site [ion binding]; other site 272626001801 MarR family; Region: MarR_2; cl17246 272626001802 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272626001803 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 272626001804 putative NAD(P) binding site [chemical binding]; other site 272626001805 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272626001806 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272626001807 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 272626001808 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272626001809 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272626001810 putative active site [active] 272626001811 catalytic site [active] 272626001812 putative metal binding site [ion binding]; other site 272626001813 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272626001814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272626001815 active site 272626001816 ATP binding site [chemical binding]; other site 272626001817 substrate binding site [chemical binding]; other site 272626001818 activation loop (A-loop); other site 272626001819 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 272626001820 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272626001821 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 272626001822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626001823 Coenzyme A binding pocket [chemical binding]; other site 272626001824 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272626001825 active site 272626001826 catalytic triad [active] 272626001827 oxyanion hole [active] 272626001828 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272626001829 domain interaction interfaces [polypeptide binding]; other site 272626001830 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272626001831 domain interaction interfaces [polypeptide binding]; other site 272626001832 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272626001833 domain interaction interfaces [polypeptide binding]; other site 272626001834 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 272626001835 domain interaction interfaces [polypeptide binding]; other site 272626001836 Isochorismatase family; Region: Isochorismatase; pfam00857 272626001837 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 272626001838 catalytic triad [active] 272626001839 conserved cis-peptide bond; other site 272626001840 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272626001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001842 motif II; other site 272626001843 Predicted transcriptional regulator [Transcription]; Region: COG1959 272626001844 Transcriptional regulator; Region: Rrf2; pfam02082 272626001845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626001846 S-adenosylmethionine binding site [chemical binding]; other site 272626001847 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 272626001848 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626001849 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626001850 active site 272626001851 catalytic tetrad [active] 272626001852 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272626001853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626001854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001855 motif II; other site 272626001856 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 272626001857 catalytic residue [active] 272626001858 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272626001859 Sulfatase; Region: Sulfatase; pfam00884 272626001860 amino acid transporter; Region: 2A0306; TIGR00909 272626001861 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272626001862 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 272626001863 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 272626001864 putative metal binding site [ion binding]; other site 272626001865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272626001866 active site 272626001867 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272626001868 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272626001869 Cl binding site [ion binding]; other site 272626001870 oligomer interface [polypeptide binding]; other site 272626001871 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272626001872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626001873 DNA-binding site [nucleotide binding]; DNA binding site 272626001874 Predicted membrane protein [Function unknown]; Region: COG1511 272626001875 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272626001876 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 272626001877 linker region; other site 272626001878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626001879 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272626001880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626001881 DNA-binding site [nucleotide binding]; DNA binding site 272626001882 FCD domain; Region: FCD; cl11656 272626001883 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272626001884 Predicted integral membrane protein [Function unknown]; Region: COG5523 272626001885 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272626001886 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272626001887 active site 272626001888 metal binding site [ion binding]; metal-binding site 272626001889 Predicted membrane protein [Function unknown]; Region: COG2322 272626001890 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626001891 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626001892 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272626001893 Leucine-rich repeats; other site 272626001894 Substrate binding site [chemical binding]; other site 272626001895 LRR adjacent; Region: LRR_adjacent; pfam08191 272626001896 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626001897 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 272626001898 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272626001899 minor groove reading motif; other site 272626001900 helix-hairpin-helix signature motif; other site 272626001901 substrate binding pocket [chemical binding]; other site 272626001902 active site 272626001903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626001904 non-specific DNA binding site [nucleotide binding]; other site 272626001905 salt bridge; other site 272626001906 sequence-specific DNA binding site [nucleotide binding]; other site 272626001907 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272626001908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272626001909 Transposase; Region: HTH_Tnp_1; cl17663 272626001910 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272626001911 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272626001912 dimer interface [polypeptide binding]; other site 272626001913 substrate binding site [chemical binding]; other site 272626001914 ATP binding site [chemical binding]; other site 272626001915 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626001916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001917 active site 272626001918 motif I; other site 272626001919 motif II; other site 272626001920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626001921 maltose O-acetyltransferase; Provisional; Region: PRK10092 272626001922 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272626001923 active site 272626001924 substrate binding site [chemical binding]; other site 272626001925 trimer interface [polypeptide binding]; other site 272626001926 CoA binding site [chemical binding]; other site 272626001927 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 272626001928 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626001929 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626001930 Walker A/P-loop; other site 272626001931 ATP binding site [chemical binding]; other site 272626001932 Q-loop/lid; other site 272626001933 ABC transporter signature motif; other site 272626001934 Walker B; other site 272626001935 D-loop; other site 272626001936 H-loop/switch region; other site 272626001937 inner membrane transport permease; Provisional; Region: PRK15066 272626001938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272626001939 oxidoreductase; Provisional; Region: PRK07985 272626001940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626001941 NAD(P) binding site [chemical binding]; other site 272626001942 active site 272626001943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 272626001944 Predicted membrane protein [Function unknown]; Region: COG3152 272626001945 Predicted membrane protein [Function unknown]; Region: COG3152 272626001946 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 272626001947 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 272626001948 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 272626001949 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 272626001950 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 272626001951 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 272626001952 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 272626001953 FHIPEP family; Region: FHIPEP; pfam00771 272626001954 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 272626001955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272626001956 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 272626001957 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272626001958 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 272626001959 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 272626001960 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 272626001961 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 272626001962 flagellar motor protein MotA; Validated; Region: PRK08124 272626001963 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 272626001964 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 272626001965 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272626001966 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272626001967 ligand binding site [chemical binding]; other site 272626001968 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272626001969 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272626001970 putative metal binding site; other site 272626001971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626001972 binding surface 272626001973 TPR motif; other site 272626001974 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 272626001975 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272626001976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626001977 active site 272626001978 phosphorylation site [posttranslational modification] 272626001979 intermolecular recognition site; other site 272626001980 dimerization interface [polypeptide binding]; other site 272626001981 flagellin; Provisional; Region: PRK12805 272626001982 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272626001983 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272626001984 Response regulator receiver domain; Region: Response_reg; pfam00072 272626001985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626001986 active site 272626001987 phosphorylation site [posttranslational modification] 272626001988 intermolecular recognition site; other site 272626001989 dimerization interface [polypeptide binding]; other site 272626001990 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 272626001991 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272626001992 putative binding surface; other site 272626001993 active site 272626001994 P2 response regulator binding domain; Region: P2; pfam07194 272626001995 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 272626001996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626001997 ATP binding site [chemical binding]; other site 272626001998 Mg2+ binding site [ion binding]; other site 272626001999 G-X-G motif; other site 272626002000 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 272626002001 flagellar motor switch protein; Validated; Region: PRK06788 272626002002 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272626002003 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 272626002004 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272626002005 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 272626002006 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272626002007 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 272626002008 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272626002009 flagellar motor switch protein; Validated; Region: PRK06789 272626002010 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 272626002011 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272626002012 flagellar motor switch protein; Reviewed; Region: PRK06782 272626002013 CheC-like family; Region: CheC; pfam04509 272626002014 CheC-like family; Region: CheC; pfam04509 272626002015 Chemotaxis phosphatase CheX; Region: CheX; cl15816 272626002016 CheC-like family; Region: CheC; pfam04509 272626002017 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 272626002018 Protein of unknown function (DUF327); Region: DUF327; pfam03885 272626002019 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 272626002020 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272626002021 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 272626002022 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272626002023 flagellar capping protein; Validated; Region: fliD; PRK06798 272626002024 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 272626002025 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272626002026 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 272626002027 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 272626002028 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 272626002029 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272626002030 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 272626002031 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 272626002032 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 272626002033 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272626002034 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 272626002035 FliG C-terminal domain; Region: FliG_C; pfam01706 272626002036 flagellar assembly protein H; Validated; Region: fliH; PRK06800 272626002037 Flagellar assembly protein FliH; Region: FliH; pfam02108 272626002038 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 272626002039 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272626002040 Walker A motif; other site 272626002041 ATP binding site [chemical binding]; other site 272626002042 Walker B motif; other site 272626002043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272626002044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272626002045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272626002046 catalytic residue [active] 272626002047 Predicted transcriptional regulators [Transcription]; Region: COG1695 272626002048 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272626002049 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 272626002050 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 272626002051 pyruvate oxidase; Provisional; Region: PRK08611 272626002052 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 272626002053 PYR/PP interface [polypeptide binding]; other site 272626002054 dimer interface [polypeptide binding]; other site 272626002055 tetramer interface [polypeptide binding]; other site 272626002056 TPP binding site [chemical binding]; other site 272626002057 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272626002058 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272626002059 TPP-binding site [chemical binding]; other site 272626002060 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 272626002061 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272626002062 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626002063 dimerization interface [polypeptide binding]; other site 272626002064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272626002065 dimer interface [polypeptide binding]; other site 272626002066 putative CheW interface [polypeptide binding]; other site 272626002067 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 272626002068 putative active site [active] 272626002069 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272626002070 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272626002071 glutaminase active site [active] 272626002072 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272626002073 dimer interface [polypeptide binding]; other site 272626002074 active site 272626002075 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272626002076 dimer interface [polypeptide binding]; other site 272626002077 active site 272626002078 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 272626002079 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272626002080 active site 272626002081 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 272626002082 GIY-YIG motif/motif A; other site 272626002083 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626002084 Leucine rich repeat; Region: LRR_8; pfam13855 272626002085 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626002086 LRR adjacent; Region: LRR_adjacent; pfam08191 272626002087 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626002088 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626002089 Leucine rich repeat; Region: LRR_8; pfam13855 272626002090 Leucine rich repeat; Region: LRR_8; pfam13855 272626002091 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002092 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002093 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002094 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002095 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626002096 Leucine rich repeat; Region: LRR_8; pfam13855 272626002097 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002098 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626002099 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002100 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626002101 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 272626002102 ligand binding site [chemical binding]; other site 272626002103 flexible hinge region; other site 272626002104 Predicted transcriptional regulators [Transcription]; Region: COG1725 272626002105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002106 DNA-binding site [nucleotide binding]; DNA binding site 272626002107 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272626002108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002109 Walker A/P-loop; other site 272626002110 ATP binding site [chemical binding]; other site 272626002111 Q-loop/lid; other site 272626002112 ABC transporter signature motif; other site 272626002113 Walker B; other site 272626002114 D-loop; other site 272626002115 H-loop/switch region; other site 272626002116 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626002117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002118 Walker A/P-loop; other site 272626002119 ATP binding site [chemical binding]; other site 272626002120 Q-loop/lid; other site 272626002121 similar to ABC transporter, ATP-binding protein (truncated, C terminal end) 272626002122 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272626002123 active site 272626002124 catalytic triad [active] 272626002125 oxyanion hole [active] 272626002126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626002128 Walker A/P-loop; other site 272626002129 ATP binding site [chemical binding]; other site 272626002130 Q-loop/lid; other site 272626002131 ABC transporter signature motif; other site 272626002132 Walker B; other site 272626002133 D-loop; other site 272626002134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626002135 H-loop/switch region; other site 272626002136 active site 272626002137 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272626002138 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272626002139 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272626002140 Zn binding site [ion binding]; other site 272626002141 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272626002142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626002143 Zn binding site [ion binding]; other site 272626002144 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 272626002145 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626002146 Zn binding site [ion binding]; other site 272626002147 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 272626002148 Zn binding site [ion binding]; other site 272626002149 Predicted esterase [General function prediction only]; Region: COG0400 272626002150 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272626002151 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272626002152 GTPases [General function prediction only]; Region: HflX; COG2262 272626002153 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272626002154 HflX GTPase family; Region: HflX; cd01878 272626002155 G1 box; other site 272626002156 GTP/Mg2+ binding site [chemical binding]; other site 272626002157 Switch I region; other site 272626002158 G2 box; other site 272626002159 G3 box; other site 272626002160 Switch II region; other site 272626002161 G4 box; other site 272626002162 G5 box; other site 272626002163 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272626002164 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272626002165 putative active site [active] 272626002166 putative metal binding site [ion binding]; other site 272626002167 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272626002168 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272626002169 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272626002170 Uncharacterized conserved protein [Function unknown]; Region: COG3538 272626002171 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 272626002172 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272626002173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002174 dimer interface [polypeptide binding]; other site 272626002175 conserved gate region; other site 272626002176 putative PBP binding loops; other site 272626002177 ABC-ATPase subunit interface; other site 272626002178 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626002179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002180 dimer interface [polypeptide binding]; other site 272626002181 conserved gate region; other site 272626002182 putative PBP binding loops; other site 272626002183 ABC-ATPase subunit interface; other site 272626002184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626002185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272626002186 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 272626002187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002188 DNA-binding site [nucleotide binding]; DNA binding site 272626002189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626002190 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272626002191 ligand binding site [chemical binding]; other site 272626002192 dimerization interface [polypeptide binding]; other site 272626002193 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272626002194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002195 DNA-binding site [nucleotide binding]; DNA binding site 272626002196 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 272626002197 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272626002198 putative NADP binding site [chemical binding]; other site 272626002199 putative dimer interface [polypeptide binding]; other site 272626002200 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272626002201 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272626002202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626002203 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626002204 nucleotide binding site [chemical binding]; other site 272626002205 Predicted membrane protein [Function unknown]; Region: COG4811 272626002206 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 272626002207 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272626002208 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272626002209 active site 272626002210 phosphorylation site [posttranslational modification] 272626002211 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626002212 active pocket/dimerization site; other site 272626002213 active site 272626002214 phosphorylation site [posttranslational modification] 272626002215 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272626002216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626002217 Walker A motif; other site 272626002218 ATP binding site [chemical binding]; other site 272626002219 Walker B motif; other site 272626002220 arginine finger; other site 272626002221 Transcriptional antiterminator [Transcription]; Region: COG3933 272626002222 PRD domain; Region: PRD; pfam00874 272626002223 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626002224 active pocket/dimerization site; other site 272626002225 active site 272626002226 phosphorylation site [posttranslational modification] 272626002227 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272626002228 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272626002229 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272626002230 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272626002231 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272626002232 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272626002233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 272626002234 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 272626002235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 272626002236 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272626002237 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272626002238 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272626002239 putative deacylase active site [active] 272626002240 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272626002241 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 272626002242 active site 272626002243 catalytic triad [active] 272626002244 dimer interface [polypeptide binding]; other site 272626002245 Protein of unknown function (DUF554); Region: DUF554; pfam04474 272626002246 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 272626002247 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272626002248 NAD binding site [chemical binding]; other site 272626002249 substrate binding site [chemical binding]; other site 272626002250 putative active site [active] 272626002251 Predicted permeases [General function prediction only]; Region: RarD; COG2962 272626002252 EamA-like transporter family; Region: EamA; pfam00892 272626002253 Uncharacterized conserved protein [Function unknown]; Region: COG2353 272626002254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626002255 MarR family; Region: MarR_2; pfam12802 272626002256 lysine transporter; Provisional; Region: PRK10836 272626002257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272626002258 PAS domain; Region: PAS_9; pfam13426 272626002259 putative active site [active] 272626002260 heme pocket [chemical binding]; other site 272626002261 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626002262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 272626002263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272626002264 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272626002265 synthetase active site [active] 272626002266 NTP binding site [chemical binding]; other site 272626002267 metal binding site [ion binding]; metal-binding site 272626002268 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272626002269 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626002270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626002271 non-specific DNA binding site [nucleotide binding]; other site 272626002272 salt bridge; other site 272626002273 sequence-specific DNA binding site [nucleotide binding]; other site 272626002274 Cupin domain; Region: Cupin_2; pfam07883 272626002275 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272626002276 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272626002277 Walker A/P-loop; other site 272626002278 ATP binding site [chemical binding]; other site 272626002279 Q-loop/lid; other site 272626002280 ABC transporter signature motif; other site 272626002281 Walker B; other site 272626002282 D-loop; other site 272626002283 H-loop/switch region; other site 272626002284 TOBE domain; Region: TOBE_2; pfam08402 272626002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272626002286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002287 putative PBP binding loops; other site 272626002288 ABC-ATPase subunit interface; other site 272626002289 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272626002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002291 dimer interface [polypeptide binding]; other site 272626002292 conserved gate region; other site 272626002293 putative PBP binding loops; other site 272626002294 ABC-ATPase subunit interface; other site 272626002295 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272626002296 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 272626002297 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272626002298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626002299 active site 272626002300 phosphorylation site [posttranslational modification] 272626002301 intermolecular recognition site; other site 272626002302 dimerization interface [polypeptide binding]; other site 272626002303 LytTr DNA-binding domain; Region: LytTR; pfam04397 272626002304 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272626002305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626002306 ATP binding site [chemical binding]; other site 272626002307 Mg2+ binding site [ion binding]; other site 272626002308 G-X-G motif; other site 272626002309 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272626002310 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272626002311 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272626002312 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272626002313 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272626002314 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272626002315 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002316 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002317 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002318 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002319 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002320 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002321 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002322 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002323 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002324 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002325 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002326 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272626002327 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 272626002328 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 272626002329 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272626002330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626002331 NAD(P) binding site [chemical binding]; other site 272626002332 active site 272626002333 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626002334 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272626002335 DNA binding residues [nucleotide binding] 272626002336 putative dimer interface [polypeptide binding]; other site 272626002337 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 272626002338 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 272626002339 active site 272626002340 zinc binding site [ion binding]; other site 272626002341 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272626002342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626002343 Zn2+ binding site [ion binding]; other site 272626002344 Mg2+ binding site [ion binding]; other site 272626002345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626002346 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626002347 nucleotide binding site [chemical binding]; other site 272626002348 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272626002349 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272626002350 FMN binding site [chemical binding]; other site 272626002351 substrate binding site [chemical binding]; other site 272626002352 putative catalytic residue [active] 272626002353 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626002354 MarR family; Region: MarR_2; pfam12802 272626002355 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272626002356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626002357 Coenzyme A binding pocket [chemical binding]; other site 272626002358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626002359 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272626002360 dimer interface [polypeptide binding]; other site 272626002361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626002362 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272626002363 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272626002364 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626002365 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272626002366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626002367 motif II; other site 272626002368 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272626002369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272626002370 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 272626002371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626002372 Coenzyme A binding pocket [chemical binding]; other site 272626002373 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626002374 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272626002375 DNA binding residues [nucleotide binding] 272626002376 putative dimer interface [polypeptide binding]; other site 272626002377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626002378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626002379 active site 272626002380 catalytic tetrad [active] 272626002381 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 272626002382 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272626002383 homodimer interface [polypeptide binding]; other site 272626002384 catalytic residues [active] 272626002385 NAD binding site [chemical binding]; other site 272626002386 substrate binding pocket [chemical binding]; other site 272626002387 flexible flap; other site 272626002388 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 272626002389 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272626002390 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272626002391 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272626002392 PhoU domain; Region: PhoU; pfam01895 272626002393 PhoU domain; Region: PhoU; pfam01895 272626002394 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272626002395 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272626002396 dimer interface [polypeptide binding]; other site 272626002397 PYR/PP interface [polypeptide binding]; other site 272626002398 TPP binding site [chemical binding]; other site 272626002399 substrate binding site [chemical binding]; other site 272626002400 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272626002401 Domain of unknown function; Region: EKR; smart00890 272626002402 4Fe-4S binding domain; Region: Fer4_6; pfam12837 272626002403 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272626002404 TPP-binding site [chemical binding]; other site 272626002405 dimer interface [polypeptide binding]; other site 272626002406 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 272626002407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272626002408 Predicted permeases [General function prediction only]; Region: COG0679 272626002409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272626002410 Transposase; Region: HTH_Tnp_1; cl17663 272626002411 Predicted membrane protein [Function unknown]; Region: COG3223 272626002412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626002413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626002414 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272626002415 Walker A/P-loop; other site 272626002416 ATP binding site [chemical binding]; other site 272626002417 Q-loop/lid; other site 272626002418 ABC transporter signature motif; other site 272626002419 Walker B; other site 272626002420 D-loop; other site 272626002421 H-loop/switch region; other site 272626002422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626002423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626002424 putative substrate translocation pore; other site 272626002425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626002426 MarR family; Region: MarR; pfam01047 272626002427 MarR family; Region: MarR_2; cl17246 272626002428 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272626002429 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272626002430 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626002431 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272626002432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626002433 motif II; other site 272626002434 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272626002435 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272626002436 Protein of unknown function DUF262; Region: DUF262; pfam03235 272626002437 Uncharacterized conserved protein [Function unknown]; Region: COG4938 272626002438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002439 Walker A/P-loop; other site 272626002440 ATP binding site [chemical binding]; other site 272626002441 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 272626002442 Predicted membrane protein [Function unknown]; Region: COG3326 272626002443 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272626002444 homotrimer interaction site [polypeptide binding]; other site 272626002445 putative active site [active] 272626002446 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272626002447 substrate binding site [chemical binding]; other site 272626002448 zinc-binding site [ion binding]; other site 272626002449 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272626002450 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272626002451 GIY-YIG motif/motif A; other site 272626002452 active site 272626002453 catalytic site [active] 272626002454 putative DNA binding site [nucleotide binding]; other site 272626002455 metal binding site [ion binding]; metal-binding site 272626002456 UvrB/uvrC motif; Region: UVR; pfam02151 272626002457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272626002458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272626002459 substrate binding pocket [chemical binding]; other site 272626002460 membrane-bound complex binding site; other site 272626002461 hinge residues; other site 272626002462 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272626002463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002464 dimer interface [polypeptide binding]; other site 272626002465 conserved gate region; other site 272626002466 putative PBP binding loops; other site 272626002467 ABC-ATPase subunit interface; other site 272626002468 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272626002469 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272626002470 Walker A/P-loop; other site 272626002471 ATP binding site [chemical binding]; other site 272626002472 Q-loop/lid; other site 272626002473 ABC transporter signature motif; other site 272626002474 Walker B; other site 272626002475 D-loop; other site 272626002476 H-loop/switch region; other site 272626002477 amidase; Provisional; Region: PRK11910 272626002478 Amidase; Region: Amidase; cl11426 272626002479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626002480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626002481 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272626002482 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272626002483 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272626002484 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272626002485 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272626002486 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272626002487 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272626002488 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272626002489 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 272626002490 Esterase/lipase [General function prediction only]; Region: COG1647 272626002491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626002492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626002493 DNA binding site [nucleotide binding] 272626002494 domain linker motif; other site 272626002495 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 272626002496 putative dimerization interface [polypeptide binding]; other site 272626002497 putative ligand binding site [chemical binding]; other site 272626002498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626002499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626002500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272626002501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002502 dimer interface [polypeptide binding]; other site 272626002503 conserved gate region; other site 272626002504 putative PBP binding loops; other site 272626002505 ABC-ATPase subunit interface; other site 272626002506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626002507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002508 dimer interface [polypeptide binding]; other site 272626002509 conserved gate region; other site 272626002510 ABC-ATPase subunit interface; other site 272626002511 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272626002512 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272626002513 Ca binding site [ion binding]; other site 272626002514 active site 272626002515 catalytic site [active] 272626002516 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 272626002517 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 272626002518 active site 272626002519 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272626002520 active site 272626002521 substrate binding site [chemical binding]; other site 272626002522 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272626002523 metal binding site [ion binding]; metal-binding site 272626002524 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272626002525 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272626002526 ATP binding site [chemical binding]; other site 272626002527 Mg++ binding site [ion binding]; other site 272626002528 motif III; other site 272626002529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626002530 nucleotide binding region [chemical binding]; other site 272626002531 ATP-binding site [chemical binding]; other site 272626002532 Predicted membrane protein [Function unknown]; Region: COG4708 272626002533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626002534 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 272626002535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 272626002536 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626002537 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626002538 Walker A/P-loop; other site 272626002539 ATP binding site [chemical binding]; other site 272626002540 Q-loop/lid; other site 272626002541 ABC transporter signature motif; other site 272626002542 Walker B; other site 272626002543 D-loop; other site 272626002544 H-loop/switch region; other site 272626002545 Predicted transcriptional regulators [Transcription]; Region: COG1733 272626002546 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272626002547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272626002548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626002549 putative substrate translocation pore; other site 272626002550 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626002551 PRD domain; Region: PRD; pfam00874 272626002552 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626002553 active site 272626002554 P-loop; other site 272626002555 phosphorylation site [posttranslational modification] 272626002556 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626002557 active site 272626002558 phosphorylation site [posttranslational modification] 272626002559 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626002560 methionine cluster; other site 272626002561 active site 272626002562 phosphorylation site [posttranslational modification] 272626002563 metal binding site [ion binding]; metal-binding site 272626002564 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626002565 active site 272626002566 P-loop; other site 272626002567 phosphorylation site [posttranslational modification] 272626002568 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626002569 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626002570 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272626002571 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272626002572 active site 272626002573 trimer interface [polypeptide binding]; other site 272626002574 allosteric site; other site 272626002575 active site lid [active] 272626002576 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272626002577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626002578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626002579 active site 272626002580 catalytic tetrad [active] 272626002581 aminoglycoside resistance protein; Provisional; Region: PRK13746 272626002583 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272626002584 Collagen binding domain; Region: Collagen_bind; pfam05737 272626002585 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272626002586 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626002587 Uncharacterized conserved protein [Function unknown]; Region: COG3402 272626002588 Predicted membrane protein [Function unknown]; Region: COG3428 272626002589 Bacterial PH domain; Region: DUF304; pfam03703 272626002590 Bacterial PH domain; Region: DUF304; pfam03703 272626002591 Bacterial PH domain; Region: DUF304; pfam03703 272626002592 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 272626002593 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272626002594 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 272626002595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272626002596 active site 272626002597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272626002598 dimer interface [polypeptide binding]; other site 272626002599 substrate binding site [chemical binding]; other site 272626002600 catalytic residues [active] 272626002601 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 272626002602 PemK-like protein; Region: PemK; pfam02452 272626002603 Rsbr N terminal; Region: Rsbr_N; pfam08678 272626002604 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626002605 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626002606 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272626002607 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 272626002608 ATP binding site [chemical binding]; other site 272626002609 Mg2+ binding site [ion binding]; other site 272626002610 G-X-G motif; other site 272626002611 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272626002612 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 272626002613 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272626002614 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272626002615 anti sigma factor interaction site; other site 272626002616 regulatory phosphorylation site [posttranslational modification]; other site 272626002617 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272626002618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626002619 ATP binding site [chemical binding]; other site 272626002620 Mg2+ binding site [ion binding]; other site 272626002621 G-X-G motif; other site 272626002622 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 272626002623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272626002624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272626002625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272626002626 DNA binding residues [nucleotide binding] 272626002627 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 272626002628 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272626002629 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272626002630 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272626002631 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272626002632 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272626002633 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272626002634 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272626002635 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272626002636 RNA binding site [nucleotide binding]; other site 272626002637 hypothetical protein; Provisional; Region: PRK04351 272626002638 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 272626002639 Uncharacterized conserved protein [Function unknown]; Region: COG5646 272626002640 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626002641 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626002642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626002643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002644 DNA-binding site [nucleotide binding]; DNA binding site 272626002645 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272626002646 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 272626002648 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 272626002649 glutathione reductase; Validated; Region: PRK06116 272626002650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626002651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626002652 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626002653 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626002654 catalytic core [active] 272626002655 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272626002656 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272626002657 Predicted transcriptional regulators [Transcription]; Region: COG1725 272626002658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002659 DNA-binding site [nucleotide binding]; DNA binding site 272626002660 Predicted membrane protein [General function prediction only]; Region: COG4194 272626002661 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 272626002662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272626002663 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272626002664 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272626002665 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272626002666 tetramerization interface [polypeptide binding]; other site 272626002667 NAD(P) binding site [chemical binding]; other site 272626002668 catalytic residues [active] 272626002669 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626002670 active site 272626002671 P-loop; other site 272626002672 phosphorylation site [posttranslational modification] 272626002673 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626002674 similar to phosphotransferase system enzyme IIC (truncated, C-terminal end) 272626002675 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626002676 methionine cluster; other site 272626002677 active site 272626002678 phosphorylation site [posttranslational modification] 272626002679 metal binding site [ion binding]; metal-binding site 272626002680 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626002681 beta-galactosidase; Region: BGL; TIGR03356 272626002682 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626002683 Mga helix-turn-helix domain; Region: Mga; pfam05043 272626002684 PRD domain; Region: PRD; pfam00874 272626002685 PRD domain; Region: PRD; pfam00874 272626002686 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626002687 active site 272626002688 phosphorylation site [posttranslational modification] 272626002689 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272626002690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626002691 ABC transporter; Region: ABC_tran_2; pfam12848 272626002692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626002693 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 272626002694 Predicted permeases [General function prediction only]; Region: COG0701 272626002695 Predicted membrane protein [Function unknown]; Region: COG3689 272626002696 pantothenate kinase; Provisional; Region: PRK05439 272626002697 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272626002698 ATP-binding site [chemical binding]; other site 272626002699 CoA-binding site [chemical binding]; other site 272626002700 Mg2+-binding site [ion binding]; other site 272626002701 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 272626002702 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626002703 Walker A/P-loop; other site 272626002704 ATP binding site [chemical binding]; other site 272626002705 Q-loop/lid; other site 272626002706 ABC transporter signature motif; other site 272626002707 Walker B; other site 272626002708 D-loop; other site 272626002709 H-loop/switch region; other site 272626002710 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272626002711 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272626002712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626002713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626002714 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272626002715 Sulfatase; Region: Sulfatase; pfam00884 272626002716 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272626002717 active site 272626002718 DNA binding site [nucleotide binding] 272626002719 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 272626002720 active site 272626002721 catalytic site [active] 272626002722 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272626002723 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272626002724 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272626002725 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272626002726 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272626002727 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272626002728 epoxyqueuosine reductase; Region: TIGR00276 272626002729 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272626002730 A new structural DNA glycosylase; Region: AlkD_like; cl11434 272626002731 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272626002732 dimer interface [polypeptide binding]; other site 272626002733 FMN binding site [chemical binding]; other site 272626002734 NADPH bind site [chemical binding]; other site 272626002735 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272626002736 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272626002737 active site 272626002738 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 272626002739 similar to heat shock protein HtpG (truncated, C-terminal part) 272626002740 HSP90 family protein; Provisional; Region: PRK14083 272626002741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626002742 ATP binding site [chemical binding]; other site 272626002743 Mg2+ binding site [ion binding]; other site 272626002744 G-X-G motif; other site 272626002745 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272626002746 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272626002747 dimerization interface [polypeptide binding]; other site 272626002748 DPS ferroxidase diiron center [ion binding]; other site 272626002749 ion pore; other site 272626002750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 272626002751 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272626002752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272626002753 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 272626002754 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 272626002755 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 272626002756 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 272626002757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626002758 putative substrate translocation pore; other site 272626002759 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272626002760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002761 DNA-binding site [nucleotide binding]; DNA binding site 272626002762 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272626002763 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272626002764 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272626002765 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 272626002766 Lipase (class 2); Region: Lipase_2; pfam01674 272626002767 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 272626002768 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 272626002769 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 272626002770 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 272626002771 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272626002772 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272626002773 active site 272626002774 dimer interface [polypeptide binding]; other site 272626002775 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272626002776 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272626002777 active site 272626002778 trimer interface [polypeptide binding]; other site 272626002779 allosteric site; other site 272626002780 active site lid [active] 272626002781 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272626002782 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626002783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626002784 DNA-binding site [nucleotide binding]; DNA binding site 272626002785 UTRA domain; Region: UTRA; pfam07702 272626002786 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272626002787 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272626002788 Mg++ binding site [ion binding]; other site 272626002789 putative catalytic motif [active] 272626002790 substrate binding site [chemical binding]; other site 272626002791 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272626002792 Peptidase family U32; Region: Peptidase_U32; pfam01136 272626002793 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272626002794 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272626002795 Peptidase family U32; Region: Peptidase_U32; pfam01136 272626002796 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 272626002797 heat shock protein HtpX; Provisional; Region: PRK04897 272626002798 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 272626002799 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 272626002800 catalytic residues [active] 272626002801 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272626002802 putative active site [active] 272626002803 putative metal binding residues [ion binding]; other site 272626002804 signature motif; other site 272626002805 putative triphosphate binding site [ion binding]; other site 272626002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626002807 TPR motif; other site 272626002808 binding surface 272626002809 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272626002810 synthetase active site [active] 272626002811 NTP binding site [chemical binding]; other site 272626002812 metal binding site [ion binding]; metal-binding site 272626002813 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 272626002814 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272626002815 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272626002816 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272626002817 active site 272626002818 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 272626002819 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272626002820 NAD binding site [chemical binding]; other site 272626002821 homotetramer interface [polypeptide binding]; other site 272626002822 homodimer interface [polypeptide binding]; other site 272626002823 substrate binding site [chemical binding]; other site 272626002824 active site 272626002825 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 272626002826 DltD N-terminal region; Region: DltD_N; pfam04915 272626002827 DltD central region; Region: DltD_M; pfam04918 272626002828 DltD C-terminal region; Region: DltD_C; pfam04914 272626002829 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 272626002830 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 272626002831 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 272626002832 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 272626002833 acyl-activating enzyme (AAE) consensus motif; other site 272626002834 AMP binding site [chemical binding]; other site 272626002835 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272626002836 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626002837 active site 272626002838 dimer interface [polypeptide binding]; other site 272626002839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626002840 Coenzyme A binding pocket [chemical binding]; other site 272626002841 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272626002842 Putative esterase; Region: Esterase; pfam00756 272626002843 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272626002844 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272626002845 homodimer interface [polypeptide binding]; other site 272626002846 substrate-cofactor binding pocket; other site 272626002847 catalytic residue [active] 272626002848 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272626002849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002850 Walker A/P-loop; other site 272626002851 ATP binding site [chemical binding]; other site 272626002852 Q-loop/lid; other site 272626002853 ABC transporter signature motif; other site 272626002854 Walker B; other site 272626002855 D-loop; other site 272626002856 H-loop/switch region; other site 272626002857 ABC-2 type transporter; Region: ABC2_membrane; cl17235 272626002858 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272626002859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626002860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626002861 putative substrate translocation pore; other site 272626002862 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272626002863 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 272626002864 putative oligomer interface [polypeptide binding]; other site 272626002865 putative active site [active] 272626002866 metal binding site [ion binding]; metal-binding site 272626002867 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272626002868 catalytic residues [active] 272626002869 dimer interface [polypeptide binding]; other site 272626002870 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272626002871 LytTr DNA-binding domain; Region: LytTR; pfam04397 272626002872 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626002873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002874 Walker A/P-loop; other site 272626002875 ATP binding site [chemical binding]; other site 272626002876 Q-loop/lid; other site 272626002877 ABC transporter signature motif; other site 272626002878 Walker B; other site 272626002879 D-loop; other site 272626002880 H-loop/switch region; other site 272626002881 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272626002882 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272626002883 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272626002884 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272626002885 G1 box; other site 272626002886 putative GEF interaction site [polypeptide binding]; other site 272626002887 GTP/Mg2+ binding site [chemical binding]; other site 272626002888 Switch I region; other site 272626002889 G2 box; other site 272626002890 G3 box; other site 272626002891 Switch II region; other site 272626002892 G4 box; other site 272626002893 G5 box; other site 272626002894 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272626002895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626002896 MarR family; Region: MarR_2; cl17246 272626002897 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272626002898 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272626002899 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 272626002900 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 272626002901 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272626002902 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272626002903 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 272626002904 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272626002905 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272626002906 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272626002907 DNA binding site [nucleotide binding] 272626002908 active site 272626002909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626002910 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272626002911 Walker A motif; other site 272626002912 ATP binding site [chemical binding]; other site 272626002913 Walker B motif; other site 272626002914 arginine finger; other site 272626002915 UvrB/uvrC motif; Region: UVR; pfam02151 272626002916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626002917 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272626002918 Walker A motif; other site 272626002919 ATP binding site [chemical binding]; other site 272626002920 Walker B motif; other site 272626002921 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272626002922 CAAX protease self-immunity; Region: Abi; pfam02517 272626002923 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 272626002924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272626002925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 272626002926 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272626002927 dimerization domain swap beta strand [polypeptide binding]; other site 272626002928 regulatory protein interface [polypeptide binding]; other site 272626002929 active site 272626002930 regulatory phosphorylation site [posttranslational modification]; other site 272626002931 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272626002932 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272626002933 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272626002934 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272626002935 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272626002936 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272626002937 putative active site [active] 272626002938 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272626002939 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272626002940 aminotransferase A; Validated; Region: PRK07683 272626002941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626002943 homodimer interface [polypeptide binding]; other site 272626002944 catalytic residue [active] 272626002945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 272626002946 FOG: CBS domain [General function prediction only]; Region: COG0517 272626002947 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272626002948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626002949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626002950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272626002951 dimerization interface [polypeptide binding]; other site 272626002952 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272626002953 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272626002954 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272626002955 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272626002956 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272626002957 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272626002958 metal binding site [ion binding]; metal-binding site 272626002959 putative dimer interface [polypeptide binding]; other site 272626002960 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272626002961 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272626002962 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 272626002963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626002964 Walker A/P-loop; other site 272626002965 ATP binding site [chemical binding]; other site 272626002966 Q-loop/lid; other site 272626002967 ABC transporter signature motif; other site 272626002968 Walker B; other site 272626002969 D-loop; other site 272626002970 H-loop/switch region; other site 272626002971 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272626002972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626002973 dimer interface [polypeptide binding]; other site 272626002974 conserved gate region; other site 272626002975 putative PBP binding loops; other site 272626002976 ABC-ATPase subunit interface; other site 272626002977 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272626002978 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272626002979 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272626002980 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272626002981 HPr interaction site; other site 272626002982 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272626002983 active site 272626002984 phosphorylation site [posttranslational modification] 272626002985 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 272626002986 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272626002987 S1 domain; Region: S1_2; pfam13509 272626002988 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272626002989 RNA binding site [nucleotide binding]; other site 272626002990 Predicted membrane protein [Function unknown]; Region: COG4758 272626002991 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 272626002992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 272626002993 Histidine kinase; Region: HisKA_3; pfam07730 272626002994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626002995 ATP binding site [chemical binding]; other site 272626002996 Mg2+ binding site [ion binding]; other site 272626002997 G-X-G motif; other site 272626002998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272626002999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626003000 active site 272626003001 phosphorylation site [posttranslational modification] 272626003002 intermolecular recognition site; other site 272626003003 dimerization interface [polypeptide binding]; other site 272626003004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272626003005 DNA binding residues [nucleotide binding] 272626003006 dimerization interface [polypeptide binding]; other site 272626003007 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272626003008 TrkA-N domain; Region: TrkA_N; pfam02254 272626003009 TrkA-C domain; Region: TrkA_C; pfam02080 272626003010 Predicted membrane protein [Function unknown]; Region: COG1289 272626003011 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272626003012 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272626003013 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272626003014 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272626003015 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272626003016 hypothetical protein; Provisional; Region: PRK13667 272626003017 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626003018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626003019 active site 272626003020 motif I; other site 272626003021 motif II; other site 272626003022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626003023 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 272626003024 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272626003025 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 272626003026 GTP binding site; other site 272626003027 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 272626003028 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272626003029 Walker A/P-loop; other site 272626003030 ATP binding site [chemical binding]; other site 272626003031 Q-loop/lid; other site 272626003032 ABC transporter signature motif; other site 272626003033 Walker B; other site 272626003034 D-loop; other site 272626003035 H-loop/switch region; other site 272626003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626003037 dimer interface [polypeptide binding]; other site 272626003038 conserved gate region; other site 272626003039 putative PBP binding loops; other site 272626003040 ABC-ATPase subunit interface; other site 272626003041 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 272626003042 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272626003043 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 272626003044 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272626003045 dimer interface [polypeptide binding]; other site 272626003046 putative functional site; other site 272626003047 putative MPT binding site; other site 272626003048 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272626003049 Walker A motif; other site 272626003050 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272626003051 MoaE homodimer interface [polypeptide binding]; other site 272626003052 MoaD interaction [polypeptide binding]; other site 272626003053 active site residues [active] 272626003054 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272626003055 MoaE interaction surface [polypeptide binding]; other site 272626003056 MoeB interaction surface [polypeptide binding]; other site 272626003057 thiocarboxylated glycine; other site 272626003058 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272626003059 trimer interface [polypeptide binding]; other site 272626003060 dimer interface [polypeptide binding]; other site 272626003061 putative active site [active] 272626003062 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 272626003063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272626003064 FeS/SAM binding site; other site 272626003065 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272626003066 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272626003067 MPT binding site; other site 272626003068 trimer interface [polypeptide binding]; other site 272626003069 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 272626003070 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272626003071 ATP binding site [chemical binding]; other site 272626003072 substrate interface [chemical binding]; other site 272626003073 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272626003074 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272626003075 active site 272626003076 catalytic residues [active] 272626003077 metal binding site [ion binding]; metal-binding site 272626003078 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272626003079 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272626003080 TPP-binding site [chemical binding]; other site 272626003081 tetramer interface [polypeptide binding]; other site 272626003082 heterodimer interface [polypeptide binding]; other site 272626003083 phosphorylation loop region [posttranslational modification] 272626003084 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272626003085 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272626003086 alpha subunit interface [polypeptide binding]; other site 272626003087 TPP binding site [chemical binding]; other site 272626003088 heterodimer interface [polypeptide binding]; other site 272626003089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272626003090 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 272626003091 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272626003092 E3 interaction surface; other site 272626003093 lipoyl attachment site [posttranslational modification]; other site 272626003094 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272626003095 E3 interaction surface; other site 272626003096 lipoyl attachment site [posttranslational modification]; other site 272626003097 e3 binding domain; Region: E3_binding; pfam02817 272626003098 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272626003099 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 272626003100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272626003101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626003102 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626003103 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 272626003104 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 272626003105 NAD(P) binding site [chemical binding]; other site 272626003106 LDH/MDH dimer interface [polypeptide binding]; other site 272626003107 substrate binding site [chemical binding]; other site 272626003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 272626003109 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272626003110 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 272626003111 catalytic residues [active] 272626003112 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272626003113 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272626003114 Cl binding site [ion binding]; other site 272626003115 oligomer interface [polypeptide binding]; other site 272626003116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 272626003117 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 272626003118 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 272626003119 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272626003120 active site 272626003121 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272626003122 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272626003123 G1 box; other site 272626003124 putative GEF interaction site [polypeptide binding]; other site 272626003125 GTP/Mg2+ binding site [chemical binding]; other site 272626003126 Switch I region; other site 272626003127 G2 box; other site 272626003128 G3 box; other site 272626003129 Switch II region; other site 272626003130 G4 box; other site 272626003131 G5 box; other site 272626003132 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272626003133 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272626003134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 272626003135 hypothetical protein; Provisional; Region: PRK13666 272626003136 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272626003137 pyruvate carboxylase; Reviewed; Region: PRK12999 272626003138 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272626003139 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272626003140 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272626003141 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272626003142 active site 272626003143 catalytic residues [active] 272626003144 metal binding site [ion binding]; metal-binding site 272626003145 homodimer binding site [polypeptide binding]; other site 272626003146 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272626003147 carboxyltransferase (CT) interaction site; other site 272626003148 biotinylation site [posttranslational modification]; other site 272626003149 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 272626003150 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272626003151 putative binding site residues; other site 272626003152 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272626003153 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272626003154 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272626003155 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272626003156 Walker A/P-loop; other site 272626003157 ATP binding site [chemical binding]; other site 272626003158 Q-loop/lid; other site 272626003159 ABC transporter signature motif; other site 272626003160 Walker B; other site 272626003161 D-loop; other site 272626003162 H-loop/switch region; other site 272626003163 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626003164 SH3-like domain; Region: SH3_8; pfam13457 272626003165 SH3-like domain; Region: SH3_8; pfam13457 272626003166 SH3-like domain; Region: SH3_8; pfam13457 272626003167 SH3-like domain; Region: SH3_8; pfam13457 272626003168 SH3-like domain; Region: SH3_8; pfam13457 272626003169 SH3-like domain; Region: SH3_8; pfam13457 272626003170 SH3-like domain; Region: SH3_8; pfam13457 272626003171 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272626003172 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272626003173 Ligand binding site; other site 272626003174 Putative Catalytic site; other site 272626003175 DXD motif; other site 272626003176 Cobalt transport protein; Region: CbiQ; cl00463 272626003177 conserved hypothetical integral membrane protein; Region: TIGR03766 272626003178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272626003179 active site 272626003180 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272626003181 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272626003182 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272626003183 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272626003184 active site 272626003185 tetramer interface; other site 272626003186 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272626003187 substrate binding site; other site 272626003188 dimer interface; other site 272626003189 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 272626003190 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272626003191 putative NAD(P) binding site [chemical binding]; other site 272626003192 putative catalytic Zn binding site [ion binding]; other site 272626003193 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272626003194 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272626003195 active site 272626003196 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272626003197 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272626003198 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 272626003199 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272626003200 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 272626003201 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 272626003202 active site 272626003203 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272626003204 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272626003205 active site 272626003206 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272626003207 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272626003208 homodimer interface [polypeptide binding]; other site 272626003209 NAD binding pocket [chemical binding]; other site 272626003210 ATP binding pocket [chemical binding]; other site 272626003211 Mg binding site [ion binding]; other site 272626003212 active-site loop [active] 272626003213 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272626003214 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 272626003215 active site 272626003216 P-loop; other site 272626003217 phosphorylation site [posttranslational modification] 272626003218 GMP synthase; Reviewed; Region: guaA; PRK00074 272626003219 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272626003220 AMP/PPi binding site [chemical binding]; other site 272626003221 candidate oxyanion hole; other site 272626003222 catalytic triad [active] 272626003223 potential glutamine specificity residues [chemical binding]; other site 272626003224 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272626003225 ATP Binding subdomain [chemical binding]; other site 272626003226 Dimerization subdomain; other site 272626003227 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 272626003228 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626003229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626003230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272626003231 Coenzyme A binding pocket [chemical binding]; other site 272626003232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 272626003233 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272626003234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626003235 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272626003236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626003237 Coenzyme A binding pocket [chemical binding]; other site 272626003238 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626003239 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 272626003240 DNA binding residues [nucleotide binding] 272626003241 drug binding residues [chemical binding]; other site 272626003242 dimer interface [polypeptide binding]; other site 272626003243 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272626003244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626003245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626003246 Walker A/P-loop; other site 272626003247 ATP binding site [chemical binding]; other site 272626003248 Q-loop/lid; other site 272626003249 ABC transporter signature motif; other site 272626003250 Walker B; other site 272626003251 D-loop; other site 272626003252 H-loop/switch region; other site 272626003253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626003254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626003255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626003256 Walker A/P-loop; other site 272626003257 ATP binding site [chemical binding]; other site 272626003258 Q-loop/lid; other site 272626003259 ABC transporter signature motif; other site 272626003260 Walker B; other site 272626003261 D-loop; other site 272626003262 H-loop/switch region; other site 272626003263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272626003264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626003265 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626003266 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626003267 LRR adjacent; Region: LRR_adjacent; pfam08191 272626003268 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626003269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 272626003270 Clp protease; Region: CLP_protease; pfam00574 272626003271 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272626003272 oligomer interface [polypeptide binding]; other site 272626003273 active site residues [active] 272626003274 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272626003275 dimer interface [polypeptide binding]; other site 272626003276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626003277 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 272626003278 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272626003279 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272626003280 SLBB domain; Region: SLBB; pfam10531 272626003281 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272626003282 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 272626003283 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003284 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 272626003285 putative hexamer interface [polypeptide binding]; other site 272626003286 putative hexagonal pore; other site 272626003287 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 272626003288 putative hexamer interface [polypeptide binding]; other site 272626003289 putative hexagonal pore; other site 272626003290 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 272626003291 putative hexamer interface [polypeptide binding]; other site 272626003292 putative hexagonal pore; other site 272626003293 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272626003294 G1 box; other site 272626003295 GTP/Mg2+ binding site [chemical binding]; other site 272626003296 G2 box; other site 272626003297 Switch I region; other site 272626003298 G3 box; other site 272626003299 Switch II region; other site 272626003300 G4 box; other site 272626003301 G5 box; other site 272626003302 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272626003303 homotrimer interface [polypeptide binding]; other site 272626003304 Walker A motif; other site 272626003305 GTP binding site [chemical binding]; other site 272626003306 Walker B motif; other site 272626003307 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 272626003308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626003309 catalytic core [active] 272626003310 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 272626003311 Sensory domain found in PocR; Region: PocR; pfam10114 272626003312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626003313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626003314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626003315 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003316 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 272626003317 Hexamer interface [polypeptide binding]; other site 272626003318 Hexagonal pore residue; other site 272626003319 propanediol utilization protein PduB; Provisional; Region: PRK15415 272626003320 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 272626003321 putative hexamer interface [polypeptide binding]; other site 272626003322 putative hexagonal pore; other site 272626003323 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 272626003324 putative hexamer interface [polypeptide binding]; other site 272626003325 putative hexagonal pore; other site 272626003326 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 272626003327 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 272626003328 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 272626003329 alpha-beta subunit interface [polypeptide binding]; other site 272626003330 alpha-gamma subunit interface [polypeptide binding]; other site 272626003331 active site 272626003332 substrate and K+ binding site; other site 272626003333 K+ binding site [ion binding]; other site 272626003334 cobalamin binding site [chemical binding]; other site 272626003335 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 272626003336 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 272626003337 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 272626003338 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 272626003339 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003340 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 272626003341 putative hexamer interface [polypeptide binding]; other site 272626003342 putative hexagonal pore; other site 272626003343 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003344 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 272626003345 Hexamer interface [polypeptide binding]; other site 272626003346 Hexagonal pore residue; other site 272626003347 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 272626003348 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272626003349 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272626003350 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 272626003351 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626003352 nucleotide binding site [chemical binding]; other site 272626003353 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272626003354 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 272626003355 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 272626003356 Hexamer/Pentamer interface [polypeptide binding]; other site 272626003357 central pore; other site 272626003358 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272626003359 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 272626003360 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 272626003361 putative catalytic cysteine [active] 272626003362 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272626003363 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 272626003364 putative active site [active] 272626003365 metal binding site [ion binding]; metal-binding site 272626003366 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272626003367 amphipathic channel; other site 272626003368 Asn-Pro-Ala signature motifs; other site 272626003369 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272626003370 propionate/acetate kinase; Provisional; Region: PRK12379 272626003371 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 272626003372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626003373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626003374 homodimer interface [polypeptide binding]; other site 272626003375 catalytic residue [active] 272626003376 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 272626003377 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272626003378 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272626003379 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 272626003380 putative active site [active] 272626003381 metal binding site [ion binding]; metal-binding site 272626003382 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 272626003383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626003384 active site 272626003385 phosphorylation site [posttranslational modification] 272626003386 intermolecular recognition site; other site 272626003387 dimerization interface [polypeptide binding]; other site 272626003388 ANTAR domain; Region: ANTAR; pfam03861 272626003389 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 272626003390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272626003391 Histidine kinase; Region: HisKA_2; pfam07568 272626003392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626003393 ATP binding site [chemical binding]; other site 272626003394 Mg2+ binding site [ion binding]; other site 272626003395 G-X-G motif; other site 272626003396 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 272626003397 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 272626003398 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 272626003399 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 272626003400 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 272626003401 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 272626003402 putative hexamer interface [polypeptide binding]; other site 272626003403 putative hexagonal pore; other site 272626003404 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 272626003405 putative hexamer interface [polypeptide binding]; other site 272626003406 putative hexagonal pore; other site 272626003407 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003408 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 272626003409 Hexamer interface [polypeptide binding]; other site 272626003410 Hexagonal pore residue; other site 272626003411 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272626003412 putative catalytic cysteine [active] 272626003413 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272626003414 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 272626003415 Hexamer interface [polypeptide binding]; other site 272626003416 Putative hexagonal pore residue; other site 272626003417 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 272626003418 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 272626003419 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272626003420 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272626003421 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 272626003422 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 272626003423 Hexamer/Pentamer interface [polypeptide binding]; other site 272626003424 central pore; other site 272626003425 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 272626003426 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 272626003427 putative hexamer interface [polypeptide binding]; other site 272626003428 putative hexagonal pore; other site 272626003429 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 272626003430 putative hexamer interface [polypeptide binding]; other site 272626003431 putative hexagonal pore; other site 272626003432 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 272626003433 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 272626003434 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 272626003435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626003436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626003437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626003438 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 272626003439 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272626003440 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 272626003441 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 272626003442 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272626003443 catalytic triad [active] 272626003444 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 272626003445 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 272626003446 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 272626003447 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 272626003448 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272626003449 active site 272626003450 putative homodimer interface [polypeptide binding]; other site 272626003451 SAM binding site [chemical binding]; other site 272626003452 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 272626003453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626003454 S-adenosylmethionine binding site [chemical binding]; other site 272626003455 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272626003456 active site 272626003457 SAM binding site [chemical binding]; other site 272626003458 homodimer interface [polypeptide binding]; other site 272626003459 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 272626003460 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 272626003461 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 272626003462 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272626003463 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272626003464 active site 272626003465 SAM binding site [chemical binding]; other site 272626003466 homodimer interface [polypeptide binding]; other site 272626003467 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 272626003468 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 272626003469 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272626003470 active site 272626003471 SAM binding site [chemical binding]; other site 272626003472 homodimer interface [polypeptide binding]; other site 272626003473 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 272626003474 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272626003475 active site 272626003476 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 272626003477 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 272626003478 active site 272626003479 C-terminal domain interface [polypeptide binding]; other site 272626003480 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 272626003481 active site 272626003482 N-terminal domain interface [polypeptide binding]; other site 272626003483 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272626003484 active site 272626003485 SAM binding site [chemical binding]; other site 272626003486 homodimer interface [polypeptide binding]; other site 272626003487 cobalt transport protein CbiM; Validated; Region: PRK08319 272626003488 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 272626003489 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 272626003490 cobalt transport protein CbiQ; Provisional; Region: PRK15485 272626003491 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 272626003492 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272626003493 Walker A/P-loop; other site 272626003494 ATP binding site [chemical binding]; other site 272626003495 Q-loop/lid; other site 272626003496 ABC transporter signature motif; other site 272626003497 Walker B; other site 272626003498 D-loop; other site 272626003499 H-loop/switch region; other site 272626003500 cobyric acid synthase; Provisional; Region: PRK00784 272626003501 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272626003502 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272626003503 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272626003504 catalytic triad [active] 272626003505 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272626003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272626003507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272626003508 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 272626003509 AAA domain; Region: AAA_17; pfam13207 272626003510 Predicted transcriptional regulators [Transcription]; Region: COG1695 272626003511 Transcriptional regulator PadR-like family; Region: PadR; cl17335 272626003512 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 272626003513 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626003514 SH3-like domain; Region: SH3_8; pfam13457 272626003515 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626003516 SH3-like domain; Region: SH3_8; pfam13457 272626003517 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272626003518 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272626003519 oligomer interface [polypeptide binding]; other site 272626003520 active site 272626003521 metal binding site [ion binding]; metal-binding site 272626003522 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272626003523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272626003524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272626003525 Predicted transcriptional regulators [Transcription]; Region: COG1733 272626003526 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272626003527 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272626003528 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272626003529 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272626003530 dimer interface [polypeptide binding]; other site 272626003531 motif 1; other site 272626003532 active site 272626003533 motif 2; other site 272626003534 motif 3; other site 272626003535 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272626003536 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272626003537 putative tRNA-binding site [nucleotide binding]; other site 272626003538 B3/4 domain; Region: B3_4; pfam03483 272626003539 tRNA synthetase B5 domain; Region: B5; smart00874 272626003540 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272626003541 dimer interface [polypeptide binding]; other site 272626003542 motif 1; other site 272626003543 motif 3; other site 272626003544 motif 2; other site 272626003545 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272626003546 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626003547 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626003548 Walker A/P-loop; other site 272626003549 ATP binding site [chemical binding]; other site 272626003550 Q-loop/lid; other site 272626003551 ABC transporter signature motif; other site 272626003552 Walker B; other site 272626003553 D-loop; other site 272626003554 H-loop/switch region; other site 272626003555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626003556 FtsX-like permease family; Region: FtsX; pfam02687 272626003557 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272626003558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626003559 FtsX-like permease family; Region: FtsX; pfam02687 272626003560 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626003561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626003562 putative DNA binding site [nucleotide binding]; other site 272626003563 putative Zn2+ binding site [ion binding]; other site 272626003564 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272626003565 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 272626003566 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 272626003567 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272626003568 ligand binding site [chemical binding]; other site 272626003569 active site 272626003570 UGI interface [polypeptide binding]; other site 272626003571 catalytic site [active] 272626003572 ribonuclease HIII; Provisional; Region: PRK00996 272626003573 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 272626003574 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272626003575 RNA/DNA hybrid binding site [nucleotide binding]; other site 272626003576 active site 272626003577 Cell division protein ZapA; Region: ZapA; cl01146 272626003578 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272626003579 Colicin V production protein; Region: Colicin_V; pfam02674 272626003580 hypothetical protein; Provisional; Region: PRK08609 272626003581 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 272626003582 active site 272626003583 primer binding site [nucleotide binding]; other site 272626003584 NTP binding site [chemical binding]; other site 272626003585 metal binding triad [ion binding]; metal-binding site 272626003586 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 272626003587 active site 272626003588 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272626003589 MutS domain III; Region: MutS_III; pfam05192 272626003590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626003591 Walker A/P-loop; other site 272626003592 ATP binding site [chemical binding]; other site 272626003593 Q-loop/lid; other site 272626003594 ABC transporter signature motif; other site 272626003595 Walker B; other site 272626003596 D-loop; other site 272626003597 H-loop/switch region; other site 272626003598 Smr domain; Region: Smr; pfam01713 272626003599 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626003600 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272626003601 catalytic residues [active] 272626003602 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272626003603 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272626003604 GIY-YIG motif/motif A; other site 272626003605 active site 272626003606 catalytic site [active] 272626003607 putative DNA binding site [nucleotide binding]; other site 272626003608 metal binding site [ion binding]; metal-binding site 272626003609 UvrB/uvrC motif; Region: UVR; pfam02151 272626003610 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272626003611 aspartate kinase; Reviewed; Region: PRK06635 272626003612 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 272626003613 putative nucleotide binding site [chemical binding]; other site 272626003614 putative catalytic residues [active] 272626003615 putative Mg ion binding site [ion binding]; other site 272626003616 putative aspartate binding site [chemical binding]; other site 272626003617 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 272626003618 putative allosteric regulatory site; other site 272626003619 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 272626003620 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 272626003621 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 272626003622 ribonuclease PH; Reviewed; Region: rph; PRK00173 272626003623 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272626003624 hexamer interface [polypeptide binding]; other site 272626003625 active site 272626003626 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272626003627 active site 272626003628 dimerization interface [polypeptide binding]; other site 272626003629 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272626003630 active site 272626003631 metal binding site [ion binding]; metal-binding site 272626003632 homotetramer interface [polypeptide binding]; other site 272626003633 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 272626003634 Leucine rich repeat; Region: LRR_8; pfam13855 272626003635 LRR adjacent; Region: LRR_adjacent; pfam08191 272626003636 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626003637 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626003638 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626003639 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626003640 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626003641 Uncharacterized conserved protein [Function unknown]; Region: COG5361 272626003642 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 272626003643 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 272626003644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 272626003645 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 272626003646 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 272626003647 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272626003648 dimer interface [polypeptide binding]; other site 272626003649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626003650 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626003651 catalytic core [active] 272626003652 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626003653 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272626003654 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272626003655 ATP binding site [chemical binding]; other site 272626003656 Mg++ binding site [ion binding]; other site 272626003657 motif III; other site 272626003658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626003659 nucleotide binding region [chemical binding]; other site 272626003660 ATP-binding site [chemical binding]; other site 272626003661 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 272626003662 RNA binding site [nucleotide binding]; other site 272626003663 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272626003664 putative active site [active] 272626003665 nucleotide binding site [chemical binding]; other site 272626003666 nudix motif; other site 272626003667 putative metal binding site [ion binding]; other site 272626003668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626003669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626003670 putative substrate translocation pore; other site 272626003671 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626003672 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626003673 ligand binding site [chemical binding]; other site 272626003674 flexible hinge region; other site 272626003675 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272626003676 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272626003677 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626003678 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626003679 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272626003680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626003681 DNA-binding site [nucleotide binding]; DNA binding site 272626003682 UTRA domain; Region: UTRA; pfam07702 272626003683 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272626003684 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272626003685 Ca binding site [ion binding]; other site 272626003686 active site 272626003687 catalytic site [active] 272626003688 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 272626003689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272626003690 active site turn [active] 272626003691 phosphorylation site [posttranslational modification] 272626003692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272626003693 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272626003694 nudix motif; other site 272626003695 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272626003696 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626003697 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272626003698 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272626003699 putative catalytic cysteine [active] 272626003700 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 272626003701 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272626003702 nucleotide binding site [chemical binding]; other site 272626003703 homotetrameric interface [polypeptide binding]; other site 272626003704 putative phosphate binding site [ion binding]; other site 272626003705 putative allosteric binding site; other site 272626003706 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 272626003707 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 272626003708 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626003709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626003710 non-specific DNA binding site [nucleotide binding]; other site 272626003711 salt bridge; other site 272626003712 sequence-specific DNA binding site [nucleotide binding]; other site 272626003713 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272626003714 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272626003715 catalytic residues [active] 272626003716 catalytic nucleophile [active] 272626003717 Recombinase; Region: Recombinase; pfam07508 272626003718 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272626003719 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272626003720 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626003721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626003722 non-specific DNA binding site [nucleotide binding]; other site 272626003723 salt bridge; other site 272626003724 sequence-specific DNA binding site [nucleotide binding]; other site 272626003725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626003726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626003727 non-specific DNA binding site [nucleotide binding]; other site 272626003728 salt bridge; other site 272626003729 sequence-specific DNA binding site [nucleotide binding]; other site 272626003730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626003731 AAA domain; Region: AAA_23; pfam13476 272626003732 Walker A/P-loop; other site 272626003733 ATP binding site [chemical binding]; other site 272626003734 phage recombination protein Bet; Region: bet_lambda; TIGR01913 272626003735 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272626003736 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 272626003737 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272626003738 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272626003739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626003740 Walker A motif; other site 272626003741 ATP binding site [chemical binding]; other site 272626003742 Walker B motif; other site 272626003743 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 272626003744 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 272626003745 PcfK-like protein; Region: PcfK; pfam14058 272626003746 PcfJ-like protein; Region: PcfJ; pfam14284 272626003747 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272626003748 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626003749 Int/Topo IB signature motif; other site 272626003750 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 272626003751 Protein of unknown function (DUF968); Region: DUF968; pfam06147 272626003752 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272626003753 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272626003754 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272626003755 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 272626003756 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272626003757 ParB-like nuclease domain; Region: ParB; smart00470 272626003758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626003759 S-adenosylmethionine binding site [chemical binding]; other site 272626003760 DNA methylase; Region: N6_N4_Mtase; cl17433 272626003761 Uncharacterized conserved protein [Function unknown]; Region: COG5484 272626003762 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 272626003763 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 272626003764 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 272626003765 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 272626003766 Phage capsid family; Region: Phage_capsid; pfam05065 272626003767 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 272626003768 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 272626003769 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 272626003770 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 272626003771 Phage XkdN-like protein; Region: XkdN; pfam08890 272626003772 similar to phage protein (truncated, C-terminal end) 272626003773 Mu-like prophage protein [General function prediction only]; Region: COG3941 272626003774 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 272626003775 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 272626003776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626003777 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 272626003778 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 272626003779 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 272626003780 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 272626003781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272626003782 Small integral membrane protein [Function unknown]; Region: COG5546 272626003783 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272626003784 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272626003785 active site 272626003786 metal binding site [ion binding]; metal-binding site 272626003787 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 272626003788 non-specific DNA binding site [nucleotide binding]; other site 272626003789 salt bridge; other site 272626003790 sequence-specific DNA binding site [nucleotide binding]; other site 272626003791 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 272626003792 active site 272626003793 trigger factor; Provisional; Region: tig; PRK01490 272626003794 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272626003795 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272626003796 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272626003797 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272626003798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626003799 Walker A motif; other site 272626003800 ATP binding site [chemical binding]; other site 272626003801 Walker B motif; other site 272626003802 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272626003803 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272626003804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272626003805 Catalytic site [active] 272626003806 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272626003807 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272626003808 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272626003809 Catalytic site [active] 272626003810 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272626003811 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 272626003812 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272626003813 Catalytic site [active] 272626003814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272626003815 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 272626003816 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272626003817 GTP/Mg2+ binding site [chemical binding]; other site 272626003818 G4 box; other site 272626003819 G5 box; other site 272626003820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272626003821 G1 box; other site 272626003822 G1 box; other site 272626003823 GTP/Mg2+ binding site [chemical binding]; other site 272626003824 Switch I region; other site 272626003825 G2 box; other site 272626003826 G2 box; other site 272626003827 G3 box; other site 272626003828 G3 box; other site 272626003829 Switch II region; other site 272626003830 Switch II region; other site 272626003831 G5 box; other site 272626003832 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272626003833 RNA/DNA hybrid binding site [nucleotide binding]; other site 272626003834 active site 272626003835 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272626003836 DNA protecting protein DprA; Region: dprA; TIGR00732 272626003837 DNA topoisomerase I; Validated; Region: PRK05582 272626003838 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272626003839 active site 272626003840 interdomain interaction site; other site 272626003841 putative metal-binding site [ion binding]; other site 272626003842 nucleotide binding site [chemical binding]; other site 272626003843 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272626003844 domain I; other site 272626003845 DNA binding groove [nucleotide binding] 272626003846 phosphate binding site [ion binding]; other site 272626003847 domain II; other site 272626003848 domain III; other site 272626003849 nucleotide binding site [chemical binding]; other site 272626003850 catalytic site [active] 272626003851 domain IV; other site 272626003852 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272626003853 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272626003854 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272626003855 Glucose inhibited division protein A; Region: GIDA; pfam01134 272626003856 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272626003857 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272626003858 active site 272626003859 DNA binding site [nucleotide binding] 272626003860 Int/Topo IB signature motif; other site 272626003861 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272626003862 active site 272626003863 HslU subunit interaction site [polypeptide binding]; other site 272626003864 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272626003865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626003866 Walker A motif; other site 272626003867 ATP binding site [chemical binding]; other site 272626003868 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272626003869 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272626003870 transcriptional repressor CodY; Validated; Region: PRK04158 272626003871 CodY GAF-like domain; Region: CodY; pfam06018 272626003872 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 272626003873 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272626003874 active site 272626003875 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272626003876 active site 272626003877 catalytic residues [active] 272626003878 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272626003879 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272626003880 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272626003881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626003882 Mg2+ binding site [ion binding]; other site 272626003883 G-X-G motif; other site 272626003884 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272626003885 anchoring element; other site 272626003886 dimer interface [polypeptide binding]; other site 272626003887 ATP binding site [chemical binding]; other site 272626003888 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272626003889 active site 272626003890 putative metal-binding site [ion binding]; other site 272626003891 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272626003892 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272626003893 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272626003894 CAP-like domain; other site 272626003895 active site 272626003896 primary dimer interface [polypeptide binding]; other site 272626003897 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272626003898 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 272626003899 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 272626003900 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626003901 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626003902 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272626003903 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 272626003904 catalytic triad [active] 272626003905 catalytic triad [active] 272626003906 oxyanion hole [active] 272626003907 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272626003908 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272626003909 active site 272626003910 catalytic site [active] 272626003911 metal binding site [ion binding]; metal-binding site 272626003912 dimer interface [polypeptide binding]; other site 272626003913 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 272626003914 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272626003915 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272626003916 bacterial Hfq-like; Region: Hfq; cd01716 272626003917 hexamer interface [polypeptide binding]; other site 272626003918 Sm1 motif; other site 272626003919 RNA binding site [nucleotide binding]; other site 272626003920 Sm2 motif; other site 272626003921 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272626003922 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272626003923 HflX GTPase family; Region: HflX; cd01878 272626003924 G1 box; other site 272626003925 GTP/Mg2+ binding site [chemical binding]; other site 272626003926 Switch I region; other site 272626003927 G2 box; other site 272626003928 G3 box; other site 272626003929 Switch II region; other site 272626003930 G4 box; other site 272626003931 G5 box; other site 272626003932 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 272626003933 Aluminium resistance protein; Region: Alum_res; pfam06838 272626003934 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 272626003935 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272626003936 DNA binding residues [nucleotide binding] 272626003937 putative dimer interface [polypeptide binding]; other site 272626003938 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272626003939 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272626003940 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272626003941 arsenical pump membrane protein; Provisional; Region: PRK15445 272626003942 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272626003943 transmembrane helices; other site 272626003944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272626003945 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272626003946 LexA repressor; Validated; Region: PRK00215 272626003947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626003948 putative DNA binding site [nucleotide binding]; other site 272626003949 putative Zn2+ binding site [ion binding]; other site 272626003950 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272626003951 Catalytic site [active] 272626003952 cell division suppressor protein YneA; Provisional; Region: PRK14125 272626003953 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 272626003954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 272626003955 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272626003956 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272626003957 TPP-binding site [chemical binding]; other site 272626003958 dimer interface [polypeptide binding]; other site 272626003959 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272626003960 PYR/PP interface [polypeptide binding]; other site 272626003961 dimer interface [polypeptide binding]; other site 272626003962 TPP binding site [chemical binding]; other site 272626003963 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272626003964 hypothetical protein; Provisional; Region: PRK01844 272626003965 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272626003966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626003967 S-adenosylmethionine binding site [chemical binding]; other site 272626003968 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272626003969 ParB-like nuclease domain; Region: ParBc; pfam02195 272626003970 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 272626003971 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272626003972 Active Sites [active] 272626003973 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 272626003974 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272626003975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272626003976 ATP binding site [chemical binding]; other site 272626003977 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272626003978 putative Mg++ binding site [ion binding]; other site 272626003979 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272626003980 putative nucleotide binding site [chemical binding]; other site 272626003981 uridine monophosphate binding site [chemical binding]; other site 272626003982 homohexameric interface [polypeptide binding]; other site 272626003983 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272626003984 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272626003985 hinge region; other site 272626003986 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 272626003987 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 272626003988 catalytic residue [active] 272626003989 putative FPP diphosphate binding site; other site 272626003990 putative FPP binding hydrophobic cleft; other site 272626003991 dimer interface [polypeptide binding]; other site 272626003992 putative IPP diphosphate binding site; other site 272626003993 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272626003994 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272626003995 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 272626003996 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272626003997 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272626003998 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272626003999 RIP metalloprotease RseP; Region: TIGR00054 272626004000 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272626004001 active site 272626004002 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272626004003 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272626004004 protein binding site [polypeptide binding]; other site 272626004005 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272626004006 putative substrate binding region [chemical binding]; other site 272626004007 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272626004008 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272626004009 dimer interface [polypeptide binding]; other site 272626004010 motif 1; other site 272626004011 active site 272626004012 motif 2; other site 272626004013 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272626004014 putative deacylase active site [active] 272626004015 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272626004016 active site 272626004017 motif 3; other site 272626004018 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272626004019 anticodon binding site; other site 272626004020 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272626004021 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 272626004022 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272626004023 generic binding surface II; other site 272626004024 generic binding surface I; other site 272626004025 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272626004026 active site 272626004027 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272626004028 active site 272626004029 catalytic site [active] 272626004030 substrate binding site [chemical binding]; other site 272626004031 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272626004032 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272626004033 Sm and related proteins; Region: Sm_like; cl00259 272626004034 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272626004035 putative oligomer interface [polypeptide binding]; other site 272626004036 putative RNA binding site [nucleotide binding]; other site 272626004037 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272626004038 NusA N-terminal domain; Region: NusA_N; pfam08529 272626004039 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272626004040 RNA binding site [nucleotide binding]; other site 272626004041 homodimer interface [polypeptide binding]; other site 272626004042 NusA-like KH domain; Region: KH_5; pfam13184 272626004043 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272626004044 G-X-X-G motif; other site 272626004045 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272626004046 putative RNA binding cleft [nucleotide binding]; other site 272626004047 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272626004048 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272626004049 translation initiation factor IF-2; Region: IF-2; TIGR00487 272626004050 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272626004051 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272626004052 G1 box; other site 272626004053 putative GEF interaction site [polypeptide binding]; other site 272626004054 GTP/Mg2+ binding site [chemical binding]; other site 272626004055 Switch I region; other site 272626004056 G2 box; other site 272626004057 G3 box; other site 272626004058 Switch II region; other site 272626004059 G4 box; other site 272626004060 G5 box; other site 272626004061 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272626004062 Translation-initiation factor 2; Region: IF-2; pfam11987 272626004063 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272626004064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 272626004065 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272626004066 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 272626004067 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272626004068 RNA binding site [nucleotide binding]; other site 272626004069 active site 272626004070 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272626004071 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272626004072 active site 272626004073 Riboflavin kinase; Region: Flavokinase; smart00904 272626004074 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272626004075 16S/18S rRNA binding site [nucleotide binding]; other site 272626004076 S13e-L30e interaction site [polypeptide binding]; other site 272626004077 25S rRNA binding site [nucleotide binding]; other site 272626004078 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272626004079 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272626004080 RNase E interface [polypeptide binding]; other site 272626004081 trimer interface [polypeptide binding]; other site 272626004082 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272626004083 RNase E interface [polypeptide binding]; other site 272626004084 trimer interface [polypeptide binding]; other site 272626004085 active site 272626004086 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272626004087 putative nucleic acid binding region [nucleotide binding]; other site 272626004088 G-X-X-G motif; other site 272626004089 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272626004090 RNA binding site [nucleotide binding]; other site 272626004091 domain interface; other site 272626004092 GTPase RsgA; Reviewed; Region: PRK01889 272626004093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272626004094 RNA binding site [nucleotide binding]; other site 272626004095 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272626004096 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272626004097 GTP/Mg2+ binding site [chemical binding]; other site 272626004098 G4 box; other site 272626004099 G5 box; other site 272626004100 G1 box; other site 272626004101 Switch I region; other site 272626004102 G2 box; other site 272626004103 G3 box; other site 272626004104 Switch II region; other site 272626004105 YceG-like family; Region: YceG; pfam02618 272626004106 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272626004107 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 272626004108 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272626004109 Rhomboid family; Region: Rhomboid; pfam01694 272626004110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626004111 TPR motif; other site 272626004112 binding surface 272626004113 TPR repeat; Region: TPR_11; pfam13414 272626004114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 272626004115 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 272626004116 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626004117 nucleotide binding site [chemical binding]; other site 272626004118 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 272626004119 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272626004120 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272626004121 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272626004122 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272626004123 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272626004124 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272626004125 Type II/IV secretion system protein; Region: T2SE; pfam00437 272626004126 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272626004127 Walker A motif; other site 272626004128 ATP binding site [chemical binding]; other site 272626004129 Walker B motif; other site 272626004130 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272626004131 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272626004132 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 272626004133 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272626004134 tetramer interface [polypeptide binding]; other site 272626004135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626004136 catalytic residue [active] 272626004137 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272626004138 tetramer interface [polypeptide binding]; other site 272626004139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626004140 catalytic residue [active] 272626004141 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272626004142 active site residue [active] 272626004143 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 272626004144 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272626004145 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272626004146 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272626004147 active site 272626004148 elongation factor P; Validated; Region: PRK00529 272626004149 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272626004150 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272626004151 RNA binding site [nucleotide binding]; other site 272626004152 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272626004153 RNA binding site [nucleotide binding]; other site 272626004154 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272626004155 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272626004156 carboxyltransferase (CT) interaction site; other site 272626004157 biotinylation site [posttranslational modification]; other site 272626004158 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272626004159 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272626004160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272626004161 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272626004162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272626004163 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272626004164 putative RNA binding site [nucleotide binding]; other site 272626004165 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 272626004166 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272626004167 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272626004168 homodimer interface [polypeptide binding]; other site 272626004169 NADP binding site [chemical binding]; other site 272626004170 substrate binding site [chemical binding]; other site 272626004171 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272626004172 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272626004173 generic binding surface II; other site 272626004174 generic binding surface I; other site 272626004175 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 272626004176 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272626004177 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272626004178 substrate binding pocket [chemical binding]; other site 272626004179 chain length determination region; other site 272626004180 substrate-Mg2+ binding site; other site 272626004181 catalytic residues [active] 272626004182 aspartate-rich region 1; other site 272626004183 active site lid residues [active] 272626004184 aspartate-rich region 2; other site 272626004185 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272626004186 DNA-binding site [nucleotide binding]; DNA binding site 272626004187 RNA-binding motif; other site 272626004188 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 272626004189 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272626004190 TPP-binding site; other site 272626004191 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272626004192 PYR/PP interface [polypeptide binding]; other site 272626004193 dimer interface [polypeptide binding]; other site 272626004194 TPP binding site [chemical binding]; other site 272626004195 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272626004196 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272626004197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626004198 RNA binding surface [nucleotide binding]; other site 272626004199 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272626004200 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272626004201 arginine repressor; Provisional; Region: PRK04280 272626004202 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272626004203 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272626004204 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272626004205 Walker A/P-loop; other site 272626004206 ATP binding site [chemical binding]; other site 272626004207 Q-loop/lid; other site 272626004208 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272626004209 Q-loop/lid; other site 272626004210 ABC transporter signature motif; other site 272626004211 Walker B; other site 272626004212 D-loop; other site 272626004213 H-loop/switch region; other site 272626004214 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272626004215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626004216 nucleotide binding site [chemical binding]; other site 272626004217 Acetokinase family; Region: Acetate_kinase; cl17229 272626004218 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 272626004219 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626004220 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626004221 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 272626004222 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272626004223 tetramer interface [polypeptide binding]; other site 272626004224 TPP-binding site [chemical binding]; other site 272626004225 heterodimer interface [polypeptide binding]; other site 272626004226 phosphorylation loop region [posttranslational modification] 272626004227 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272626004228 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272626004229 alpha subunit interface [polypeptide binding]; other site 272626004230 TPP binding site [chemical binding]; other site 272626004231 heterodimer interface [polypeptide binding]; other site 272626004232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272626004233 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272626004234 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272626004235 E3 interaction surface; other site 272626004236 lipoyl attachment site [posttranslational modification]; other site 272626004237 e3 binding domain; Region: E3_binding; pfam02817 272626004238 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272626004239 peptidase T-like protein; Region: PepT-like; TIGR01883 272626004240 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272626004241 metal binding site [ion binding]; metal-binding site 272626004242 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272626004243 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272626004244 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272626004245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626004246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626004247 active site 272626004248 phosphorylation site [posttranslational modification] 272626004249 intermolecular recognition site; other site 272626004250 dimerization interface [polypeptide binding]; other site 272626004251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626004252 DNA binding site [nucleotide binding] 272626004253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272626004254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626004255 dimerization interface [polypeptide binding]; other site 272626004256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626004257 dimer interface [polypeptide binding]; other site 272626004258 phosphorylation site [posttranslational modification] 272626004259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626004260 ATP binding site [chemical binding]; other site 272626004261 Mg2+ binding site [ion binding]; other site 272626004262 G-X-G motif; other site 272626004263 OxaA-like protein precursor; Validated; Region: PRK01622 272626004264 acylphosphatase; Provisional; Region: PRK14443 272626004265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 272626004266 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272626004267 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272626004268 homotetramer interface [polypeptide binding]; other site 272626004269 FMN binding site [chemical binding]; other site 272626004270 homodimer contacts [polypeptide binding]; other site 272626004271 putative active site [active] 272626004272 putative substrate binding site [chemical binding]; other site 272626004273 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272626004274 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272626004275 active site residue [active] 272626004276 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 272626004277 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272626004278 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626004279 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626004280 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272626004281 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272626004282 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272626004283 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272626004284 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 272626004285 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 272626004286 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272626004287 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272626004288 ligand binding site [chemical binding]; other site 272626004289 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272626004290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626004291 Walker A/P-loop; other site 272626004292 ATP binding site [chemical binding]; other site 272626004293 Q-loop/lid; other site 272626004294 ABC transporter signature motif; other site 272626004295 Walker B; other site 272626004296 D-loop; other site 272626004297 H-loop/switch region; other site 272626004298 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272626004299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272626004300 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272626004301 TM-ABC transporter signature motif; other site 272626004302 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272626004303 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272626004304 TM-ABC transporter signature motif; other site 272626004305 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272626004306 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272626004307 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272626004308 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272626004309 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272626004310 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272626004311 classical (c) SDRs; Region: SDR_c; cd05233 272626004312 NAD(P) binding site [chemical binding]; other site 272626004313 active site 272626004314 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272626004315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626004316 non-specific DNA binding site [nucleotide binding]; other site 272626004317 salt bridge; other site 272626004318 sequence-specific DNA binding site [nucleotide binding]; other site 272626004319 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272626004320 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272626004321 competence damage-inducible protein A; Provisional; Region: PRK00549 272626004322 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272626004323 putative MPT binding site; other site 272626004324 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272626004325 recombinase A; Provisional; Region: recA; PRK09354 272626004326 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272626004327 hexamer interface [polypeptide binding]; other site 272626004328 Walker A motif; other site 272626004329 ATP binding site [chemical binding]; other site 272626004330 Walker B motif; other site 272626004331 phosphodiesterase; Provisional; Region: PRK12704 272626004332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626004333 Zn2+ binding site [ion binding]; other site 272626004334 Mg2+ binding site [ion binding]; other site 272626004335 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272626004336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626004337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626004338 Coenzyme A binding pocket [chemical binding]; other site 272626004339 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272626004340 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272626004341 putative active site [active] 272626004342 metal binding site [ion binding]; metal-binding site 272626004343 homodimer binding site [polypeptide binding]; other site 272626004344 Predicted membrane protein [Function unknown]; Region: COG4550 272626004345 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272626004346 MutS domain I; Region: MutS_I; pfam01624 272626004347 MutS domain II; Region: MutS_II; pfam05188 272626004348 MutS domain III; Region: MutS_III; pfam05192 272626004349 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272626004350 Walker A/P-loop; other site 272626004351 ATP binding site [chemical binding]; other site 272626004352 Q-loop/lid; other site 272626004353 ABC transporter signature motif; other site 272626004354 Walker B; other site 272626004355 D-loop; other site 272626004356 H-loop/switch region; other site 272626004357 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272626004358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626004359 ATP binding site [chemical binding]; other site 272626004360 Mg2+ binding site [ion binding]; other site 272626004361 G-X-G motif; other site 272626004362 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272626004363 ATP binding site [chemical binding]; other site 272626004364 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272626004365 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 272626004366 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272626004367 Pyruvate formate lyase 1; Region: PFL1; cd01678 272626004368 coenzyme A binding site [chemical binding]; other site 272626004369 active site 272626004370 catalytic residues [active] 272626004371 glycine loop; other site 272626004372 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 272626004373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272626004374 FeS/SAM binding site; other site 272626004375 Predicted transcriptional regulators [Transcription]; Region: COG1695 272626004376 Transcriptional regulator PadR-like family; Region: PadR; cl17335 272626004377 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 272626004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626004379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626004380 putative substrate translocation pore; other site 272626004381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626004382 non-specific DNA binding site [nucleotide binding]; other site 272626004383 salt bridge; other site 272626004384 sequence-specific DNA binding site [nucleotide binding]; other site 272626004385 topology modulation protein; Reviewed; Region: PRK08118 272626004386 AAA domain; Region: AAA_17; pfam13207 272626004387 LXG domain of WXG superfamily; Region: LXG; pfam04740 272626004388 putative acyltransferase; Provisional; Region: PRK05790 272626004389 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272626004390 dimer interface [polypeptide binding]; other site 272626004391 active site 272626004392 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272626004393 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 272626004394 dimer interface [polypeptide binding]; other site 272626004395 active site 272626004396 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272626004397 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272626004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626004399 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 272626004400 Uncharacterized conserved protein [Function unknown]; Region: COG3379 272626004401 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272626004402 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272626004403 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272626004404 FAD binding domain; Region: FAD_binding_4; pfam01565 272626004405 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272626004406 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272626004407 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 272626004408 Walker A/P-loop; other site 272626004409 ATP binding site [chemical binding]; other site 272626004410 Q-loop/lid; other site 272626004411 ABC transporter signature motif; other site 272626004412 Walker B; other site 272626004413 D-loop; other site 272626004414 H-loop/switch region; other site 272626004415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626004416 dimer interface [polypeptide binding]; other site 272626004417 conserved gate region; other site 272626004418 ABC-ATPase subunit interface; other site 272626004419 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 272626004420 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 272626004421 manganese transport protein MntH; Reviewed; Region: PRK00701 272626004422 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272626004423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626004424 dimer interface [polypeptide binding]; other site 272626004425 conserved gate region; other site 272626004426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272626004427 ABC-ATPase subunit interface; other site 272626004428 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272626004429 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272626004430 dimerization interface [polypeptide binding]; other site 272626004431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626004432 dimer interface [polypeptide binding]; other site 272626004433 conserved gate region; other site 272626004434 putative PBP binding loops; other site 272626004435 ABC-ATPase subunit interface; other site 272626004436 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 272626004437 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 272626004438 Walker A/P-loop; other site 272626004439 ATP binding site [chemical binding]; other site 272626004440 Q-loop/lid; other site 272626004441 ABC transporter signature motif; other site 272626004442 Walker B; other site 272626004443 D-loop; other site 272626004444 H-loop/switch region; other site 272626004445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 272626004446 Predicted membrane protein [Function unknown]; Region: COG3859 272626004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 272626004448 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272626004449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626004450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626004451 ABC transporter; Region: ABC_tran_2; pfam12848 272626004452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626004453 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 272626004454 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272626004455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626004456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626004457 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626004458 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272626004459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272626004460 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272626004461 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272626004462 dihydrodipicolinate synthase; Region: dapA; TIGR00674 272626004463 dimer interface [polypeptide binding]; other site 272626004464 active site 272626004465 catalytic residue [active] 272626004466 aspartate kinase I; Reviewed; Region: PRK08210 272626004467 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272626004468 nucleotide binding site [chemical binding]; other site 272626004469 substrate binding site [chemical binding]; other site 272626004470 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 272626004471 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272626004472 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272626004473 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272626004474 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272626004475 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272626004476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272626004477 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272626004478 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272626004479 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272626004480 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 272626004481 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 272626004482 Predicted membrane protein [Function unknown]; Region: COG4392 272626004483 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 272626004484 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272626004485 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272626004486 metal binding site 2 [ion binding]; metal-binding site 272626004487 putative DNA binding helix; other site 272626004488 metal binding site 1 [ion binding]; metal-binding site 272626004489 dimer interface [polypeptide binding]; other site 272626004490 structural Zn2+ binding site [ion binding]; other site 272626004491 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272626004492 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626004493 ABC-ATPase subunit interface; other site 272626004494 dimer interface [polypeptide binding]; other site 272626004495 putative PBP binding regions; other site 272626004496 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272626004497 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272626004498 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272626004499 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272626004500 DHHA2 domain; Region: DHHA2; pfam02833 272626004501 endonuclease IV; Provisional; Region: PRK01060 272626004502 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272626004503 AP (apurinic/apyrimidinic) site pocket; other site 272626004504 DNA interaction; other site 272626004505 Metal-binding active site; metal-binding site 272626004506 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272626004507 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272626004508 ATP binding site [chemical binding]; other site 272626004509 Mg++ binding site [ion binding]; other site 272626004510 motif III; other site 272626004511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626004512 nucleotide binding region [chemical binding]; other site 272626004513 ATP-binding site [chemical binding]; other site 272626004514 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272626004515 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272626004516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272626004517 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272626004518 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272626004519 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272626004520 Family of unknown function (DUF633); Region: DUF633; pfam04816 272626004521 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272626004522 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272626004523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272626004524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272626004525 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272626004526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272626004527 DNA binding residues [nucleotide binding] 272626004528 DNA primase; Validated; Region: dnaG; PRK05667 272626004529 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272626004530 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272626004531 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272626004532 active site 272626004533 metal binding site [ion binding]; metal-binding site 272626004534 interdomain interaction site; other site 272626004535 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272626004536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 272626004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 272626004538 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272626004539 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272626004540 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272626004541 dimer interface [polypeptide binding]; other site 272626004542 motif 1; other site 272626004543 active site 272626004544 motif 2; other site 272626004545 motif 3; other site 272626004546 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272626004547 Recombination protein O N terminal; Region: RecO_N; pfam11967 272626004548 Recombination protein O C terminal; Region: RecO_C; pfam02565 272626004549 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 272626004550 GTPase Era; Reviewed; Region: era; PRK00089 272626004551 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272626004552 G1 box; other site 272626004553 GTP/Mg2+ binding site [chemical binding]; other site 272626004554 Switch I region; other site 272626004555 G2 box; other site 272626004556 Switch II region; other site 272626004557 G3 box; other site 272626004558 G4 box; other site 272626004559 G5 box; other site 272626004560 KH domain; Region: KH_2; pfam07650 272626004561 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272626004562 active site 272626004563 catalytic motif [active] 272626004564 Zn binding site [ion binding]; other site 272626004565 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 272626004566 metal-binding heat shock protein; Provisional; Region: PRK00016 272626004567 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 272626004568 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 272626004569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626004570 Zn2+ binding site [ion binding]; other site 272626004571 Mg2+ binding site [ion binding]; other site 272626004572 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272626004573 PhoH-like protein; Region: PhoH; pfam02562 272626004574 Yqey-like protein; Region: YqeY; pfam09424 272626004575 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272626004576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272626004577 RNA methyltransferase, RsmE family; Region: TIGR00046 272626004578 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272626004579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626004580 S-adenosylmethionine binding site [chemical binding]; other site 272626004581 chaperone protein DnaJ; Provisional; Region: PRK14280 272626004582 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272626004583 HSP70 interaction site [polypeptide binding]; other site 272626004584 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272626004585 substrate binding site [polypeptide binding]; other site 272626004586 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272626004587 Zn binding sites [ion binding]; other site 272626004588 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272626004589 dimer interface [polypeptide binding]; other site 272626004590 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272626004591 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272626004592 nucleotide binding site [chemical binding]; other site 272626004593 NEF interaction site [polypeptide binding]; other site 272626004594 SBD interface [polypeptide binding]; other site 272626004595 heat shock protein GrpE; Provisional; Region: PRK14140 272626004596 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272626004597 dimer interface [polypeptide binding]; other site 272626004598 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272626004599 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272626004600 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 272626004601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272626004602 FeS/SAM binding site; other site 272626004603 HemN C-terminal domain; Region: HemN_C; pfam06969 272626004604 GTP-binding protein LepA; Provisional; Region: PRK05433 272626004605 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272626004606 G1 box; other site 272626004607 putative GEF interaction site [polypeptide binding]; other site 272626004608 GTP/Mg2+ binding site [chemical binding]; other site 272626004609 Switch I region; other site 272626004610 G2 box; other site 272626004611 G3 box; other site 272626004612 Switch II region; other site 272626004613 G4 box; other site 272626004614 G5 box; other site 272626004615 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272626004616 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272626004617 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272626004618 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272626004619 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272626004620 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272626004621 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272626004622 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272626004623 Competence protein; Region: Competence; pfam03772 272626004624 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272626004625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272626004626 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272626004627 catalytic motif [active] 272626004628 Zn binding site [ion binding]; other site 272626004629 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 272626004630 SLBB domain; Region: SLBB; pfam10531 272626004631 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272626004632 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272626004633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626004634 S-adenosylmethionine binding site [chemical binding]; other site 272626004635 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272626004636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626004637 Zn2+ binding site [ion binding]; other site 272626004638 Mg2+ binding site [ion binding]; other site 272626004639 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272626004640 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272626004641 active site 272626004642 (T/H)XGH motif; other site 272626004643 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 272626004644 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 272626004645 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272626004646 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272626004647 shikimate binding site; other site 272626004648 NAD(P) binding site [chemical binding]; other site 272626004649 GTPase YqeH; Provisional; Region: PRK13796 272626004650 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272626004651 GTP/Mg2+ binding site [chemical binding]; other site 272626004652 G4 box; other site 272626004653 G5 box; other site 272626004654 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272626004655 G1 box; other site 272626004656 G1 box; other site 272626004657 GTP/Mg2+ binding site [chemical binding]; other site 272626004658 G2 box; other site 272626004659 Switch I region; other site 272626004660 G2 box; other site 272626004661 Switch I region; other site 272626004662 G3 box; other site 272626004663 G3 box; other site 272626004664 Switch II region; other site 272626004665 Switch II region; other site 272626004666 G4 box; other site 272626004667 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 272626004668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626004669 motif II; other site 272626004670 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 272626004671 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 272626004672 active site 272626004673 Zn binding site [ion binding]; other site 272626004674 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272626004675 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 272626004676 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 272626004677 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272626004678 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272626004679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272626004680 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 272626004681 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272626004682 Sugar specificity; other site 272626004683 Pyrimidine base specificity; other site 272626004684 ATP-binding site [chemical binding]; other site 272626004685 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272626004686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626004687 S-adenosylmethionine binding site [chemical binding]; other site 272626004688 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 272626004689 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272626004690 dimerization interface [polypeptide binding]; other site 272626004691 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272626004692 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272626004693 hypothetical protein; Provisional; Region: PRK13678 272626004694 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272626004695 hypothetical protein; Provisional; Region: PRK05473 272626004696 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272626004697 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272626004698 motif 1; other site 272626004699 active site 272626004700 motif 2; other site 272626004701 motif 3; other site 272626004702 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272626004703 DHHA1 domain; Region: DHHA1; pfam02272 272626004704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626004705 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626004706 Walker A/P-loop; other site 272626004707 ATP binding site [chemical binding]; other site 272626004708 Q-loop/lid; other site 272626004709 ABC transporter signature motif; other site 272626004710 Walker B; other site 272626004711 D-loop; other site 272626004712 H-loop/switch region; other site 272626004713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626004714 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272626004715 FtsX-like permease family; Region: FtsX; pfam02687 272626004716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626004717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626004718 active site 272626004719 phosphorylation site [posttranslational modification] 272626004720 intermolecular recognition site; other site 272626004721 dimerization interface [polypeptide binding]; other site 272626004722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626004723 DNA binding site [nucleotide binding] 272626004724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272626004725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626004726 dimerization interface [polypeptide binding]; other site 272626004727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626004728 dimer interface [polypeptide binding]; other site 272626004729 phosphorylation site [posttranslational modification] 272626004730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626004731 ATP binding site [chemical binding]; other site 272626004732 Mg2+ binding site [ion binding]; other site 272626004733 G-X-G motif; other site 272626004734 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272626004735 AAA domain; Region: AAA_30; pfam13604 272626004736 Family description; Region: UvrD_C_2; pfam13538 272626004737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626004738 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 272626004739 TPR motif; other site 272626004740 binding surface 272626004741 TPR repeat; Region: TPR_11; pfam13414 272626004742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626004743 binding surface 272626004744 TPR motif; other site 272626004745 TPR repeat; Region: TPR_11; pfam13414 272626004746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272626004747 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272626004748 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272626004749 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272626004750 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272626004751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626004752 catalytic residue [active] 272626004753 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 272626004754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626004755 Walker A motif; other site 272626004756 ATP binding site [chemical binding]; other site 272626004757 Walker B motif; other site 272626004758 arginine finger; other site 272626004759 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272626004760 Predicted transcriptional regulator [Transcription]; Region: COG1959 272626004761 Transcriptional regulator; Region: Rrf2; pfam02082 272626004762 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272626004763 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272626004764 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272626004765 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272626004766 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272626004767 dimer interface [polypeptide binding]; other site 272626004768 anticodon binding site; other site 272626004769 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272626004770 homodimer interface [polypeptide binding]; other site 272626004771 motif 1; other site 272626004772 active site 272626004773 motif 2; other site 272626004774 GAD domain; Region: GAD; pfam02938 272626004775 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272626004776 active site 272626004777 motif 3; other site 272626004778 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272626004779 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272626004780 dimer interface [polypeptide binding]; other site 272626004781 motif 1; other site 272626004782 active site 272626004783 motif 2; other site 272626004784 motif 3; other site 272626004785 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272626004786 anticodon binding site; other site 272626004787 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 272626004788 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626004789 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626004790 Bacterial SH3 domain homologues; Region: SH3b; smart00287 272626004791 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272626004792 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272626004793 active site 272626004794 metal binding site [ion binding]; metal-binding site 272626004795 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272626004796 putative active site [active] 272626004797 dimerization interface [polypeptide binding]; other site 272626004798 putative tRNAtyr binding site [nucleotide binding]; other site 272626004799 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272626004800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626004801 Zn2+ binding site [ion binding]; other site 272626004802 Mg2+ binding site [ion binding]; other site 272626004803 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272626004804 synthetase active site [active] 272626004805 NTP binding site [chemical binding]; other site 272626004806 metal binding site [ion binding]; metal-binding site 272626004807 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272626004808 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272626004809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626004810 active site 272626004811 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272626004812 DHH family; Region: DHH; pfam01368 272626004813 DHHA1 domain; Region: DHHA1; pfam02272 272626004814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 272626004815 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 272626004816 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 272626004817 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272626004818 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272626004819 Protein export membrane protein; Region: SecD_SecF; pfam02355 272626004820 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 272626004821 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 272626004822 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272626004823 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272626004824 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272626004825 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272626004826 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272626004827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626004828 Walker A motif; other site 272626004829 ATP binding site [chemical binding]; other site 272626004830 Walker B motif; other site 272626004831 arginine finger; other site 272626004832 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272626004833 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 272626004834 RuvA N terminal domain; Region: RuvA_N; pfam01330 272626004835 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272626004836 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272626004837 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626004838 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272626004839 NAD binding site [chemical binding]; other site 272626004840 dimer interface [polypeptide binding]; other site 272626004841 substrate binding site [chemical binding]; other site 272626004842 hypothetical protein; Validated; Region: PRK00110 272626004843 prephenate dehydratase; Provisional; Region: PRK11898 272626004844 Prephenate dehydratase; Region: PDT; pfam00800 272626004845 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272626004846 putative L-Phe binding site [chemical binding]; other site 272626004847 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272626004848 GTP1/OBG; Region: GTP1_OBG; pfam01018 272626004849 Obg GTPase; Region: Obg; cd01898 272626004850 G1 box; other site 272626004851 GTP/Mg2+ binding site [chemical binding]; other site 272626004852 Switch I region; other site 272626004853 G2 box; other site 272626004854 G3 box; other site 272626004855 Switch II region; other site 272626004856 G4 box; other site 272626004857 G5 box; other site 272626004858 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272626004859 glycerol kinase; Provisional; Region: glpK; PRK00047 272626004860 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272626004861 N- and C-terminal domain interface [polypeptide binding]; other site 272626004862 active site 272626004863 MgATP binding site [chemical binding]; other site 272626004864 catalytic site [active] 272626004865 metal binding site [ion binding]; metal-binding site 272626004866 glycerol binding site [chemical binding]; other site 272626004867 homotetramer interface [polypeptide binding]; other site 272626004868 homodimer interface [polypeptide binding]; other site 272626004869 FBP binding site [chemical binding]; other site 272626004870 protein IIAGlc interface [polypeptide binding]; other site 272626004871 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272626004872 amphipathic channel; other site 272626004873 Asn-Pro-Ala signature motifs; other site 272626004874 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272626004875 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 272626004876 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272626004877 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 272626004878 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272626004879 homodimer interface [polypeptide binding]; other site 272626004880 oligonucleotide binding site [chemical binding]; other site 272626004881 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 272626004882 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272626004883 Switch I; other site 272626004884 Switch II; other site 272626004885 septum formation inhibitor; Reviewed; Region: minC; PRK00513 272626004886 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272626004887 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 272626004888 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 272626004889 Protein of unknown function (DUF972); Region: DUF972; pfam06156 272626004890 rod shape-determining protein MreC; Region: MreC; pfam04085 272626004891 rod shape-determining protein MreB; Provisional; Region: PRK13927 272626004892 MreB and similar proteins; Region: MreB_like; cd10225 272626004893 nucleotide binding site [chemical binding]; other site 272626004894 Mg binding site [ion binding]; other site 272626004895 putative protofilament interaction site [polypeptide binding]; other site 272626004896 RodZ interaction site [polypeptide binding]; other site 272626004897 hypothetical protein; Reviewed; Region: PRK00024 272626004898 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272626004899 MPN+ (JAMM) motif; other site 272626004900 Zinc-binding site [ion binding]; other site 272626004901 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272626004902 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272626004903 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272626004904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272626004905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272626004906 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272626004907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272626004908 active site 272626004909 HIGH motif; other site 272626004910 nucleotide binding site [chemical binding]; other site 272626004911 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272626004912 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272626004913 active site 272626004914 KMSKS motif; other site 272626004915 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272626004916 tRNA binding surface [nucleotide binding]; other site 272626004917 anticodon binding site; other site 272626004918 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272626004919 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272626004920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272626004921 inhibitor-cofactor binding pocket; inhibition site 272626004922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626004923 catalytic residue [active] 272626004924 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272626004925 dimer interface [polypeptide binding]; other site 272626004926 active site 272626004927 Schiff base residues; other site 272626004928 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 272626004929 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272626004930 active site 272626004931 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272626004932 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272626004933 domain interfaces; other site 272626004934 active site 272626004935 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272626004936 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272626004937 tRNA; other site 272626004938 putative tRNA binding site [nucleotide binding]; other site 272626004939 putative NADP binding site [chemical binding]; other site 272626004940 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 272626004941 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272626004942 G1 box; other site 272626004943 GTP/Mg2+ binding site [chemical binding]; other site 272626004944 Switch I region; other site 272626004945 G2 box; other site 272626004946 G3 box; other site 272626004947 Switch II region; other site 272626004948 G4 box; other site 272626004949 G5 box; other site 272626004950 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272626004951 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272626004952 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272626004953 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272626004954 active site 272626004955 dimer interface [polypeptide binding]; other site 272626004956 motif 1; other site 272626004957 motif 2; other site 272626004958 motif 3; other site 272626004959 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272626004960 anticodon binding site; other site 272626004961 primosomal protein DnaI; Reviewed; Region: PRK08939 272626004962 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272626004963 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272626004964 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272626004965 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272626004966 ATP cone domain; Region: ATP-cone; pfam03477 272626004967 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272626004968 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272626004969 CoA-binding site [chemical binding]; other site 272626004970 ATP-binding [chemical binding]; other site 272626004971 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272626004972 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272626004973 DNA binding site [nucleotide binding] 272626004974 catalytic residue [active] 272626004975 H2TH interface [polypeptide binding]; other site 272626004976 putative catalytic residues [active] 272626004977 turnover-facilitating residue; other site 272626004978 intercalation triad [nucleotide binding]; other site 272626004979 8OG recognition residue [nucleotide binding]; other site 272626004980 putative reading head residues; other site 272626004981 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272626004982 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272626004983 DNA polymerase I; Provisional; Region: PRK05755 272626004984 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272626004985 active site 272626004986 metal binding site 1 [ion binding]; metal-binding site 272626004987 putative 5' ssDNA interaction site; other site 272626004988 metal binding site 3; metal-binding site 272626004989 metal binding site 2 [ion binding]; metal-binding site 272626004990 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272626004991 putative DNA binding site [nucleotide binding]; other site 272626004992 putative metal binding site [ion binding]; other site 272626004993 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272626004994 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272626004995 active site 272626004996 DNA binding site [nucleotide binding] 272626004997 catalytic site [active] 272626004998 isocitrate dehydrogenase; Reviewed; Region: PRK07006 272626004999 isocitrate dehydrogenase; Validated; Region: PRK07362 272626005000 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 272626005001 dimer interface [polypeptide binding]; other site 272626005002 Citrate synthase; Region: Citrate_synt; pfam00285 272626005003 active site 272626005004 citrylCoA binding site [chemical binding]; other site 272626005005 oxalacetate/citrate binding site [chemical binding]; other site 272626005006 coenzyme A binding site [chemical binding]; other site 272626005007 catalytic triad [active] 272626005008 Protein of unknown function (DUF441); Region: DUF441; pfam04284 272626005009 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 272626005010 pyruvate kinase; Provisional; Region: PRK06354 272626005011 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272626005012 domain interfaces; other site 272626005013 active site 272626005014 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 272626005015 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272626005016 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 272626005017 active site 272626005018 ADP/pyrophosphate binding site [chemical binding]; other site 272626005019 dimerization interface [polypeptide binding]; other site 272626005020 allosteric effector site; other site 272626005021 fructose-1,6-bisphosphate binding site; other site 272626005022 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272626005023 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272626005024 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272626005025 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 272626005026 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272626005027 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272626005028 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272626005029 active site 272626005030 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272626005031 generic binding surface I; other site 272626005032 generic binding surface II; other site 272626005033 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272626005034 DHH family; Region: DHH; pfam01368 272626005035 DHHA1 domain; Region: DHHA1; pfam02272 272626005036 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 272626005037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272626005038 DNA-binding site [nucleotide binding]; DNA binding site 272626005039 DRTGG domain; Region: DRTGG; pfam07085 272626005040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 272626005041 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 272626005042 active site 2 [active] 272626005043 active site 1 [active] 272626005044 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272626005045 metal-dependent hydrolase; Provisional; Region: PRK00685 272626005046 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272626005047 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272626005048 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272626005049 active site 272626005050 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272626005051 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272626005052 hexamer interface [polypeptide binding]; other site 272626005053 ligand binding site [chemical binding]; other site 272626005054 putative active site [active] 272626005055 NAD(P) binding site [chemical binding]; other site 272626005056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272626005057 Ligand Binding Site [chemical binding]; other site 272626005058 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272626005059 propionate/acetate kinase; Provisional; Region: PRK12379 272626005060 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272626005061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005062 S-adenosylmethionine binding site [chemical binding]; other site 272626005063 Helix-turn-helix domain; Region: HTH_16; pfam12645 272626005064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 272626005065 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 272626005066 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272626005067 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272626005068 classical (c) SDRs; Region: SDR_c; cd05233 272626005069 NAD(P) binding site [chemical binding]; other site 272626005070 active site 272626005071 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272626005072 DNA binding residues [nucleotide binding] 272626005073 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626005074 putative dimer interface [polypeptide binding]; other site 272626005075 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272626005076 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 272626005077 putative catalytic residues [active] 272626005078 catalytic nucleophile [active] 272626005079 Recombinase; Region: Recombinase; pfam07508 272626005080 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272626005081 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 272626005082 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272626005083 dimer interface [polypeptide binding]; other site 272626005084 catalytic triad [active] 272626005085 peroxidatic and resolving cysteines [active] 272626005086 RDD family; Region: RDD; pfam06271 272626005087 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272626005088 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272626005089 tandem repeat interface [polypeptide binding]; other site 272626005090 oligomer interface [polypeptide binding]; other site 272626005091 active site residues [active] 272626005092 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 272626005093 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272626005094 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272626005095 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272626005096 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272626005097 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 272626005098 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272626005099 inhibitor-cofactor binding pocket; inhibition site 272626005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005101 catalytic residue [active] 272626005102 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 272626005103 nucleotide binding site [chemical binding]; other site 272626005104 N-acetyl-L-glutamate binding site [chemical binding]; other site 272626005105 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 272626005106 heterotetramer interface [polypeptide binding]; other site 272626005107 active site pocket [active] 272626005108 cleavage site 272626005109 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 272626005110 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272626005111 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272626005112 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272626005113 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272626005114 Ligand Binding Site [chemical binding]; other site 272626005115 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272626005116 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272626005117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626005118 catalytic residue [active] 272626005119 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 272626005120 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272626005121 GAF domain; Region: GAF_2; pfam13185 272626005122 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272626005123 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272626005124 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626005125 RNA binding surface [nucleotide binding]; other site 272626005126 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 272626005127 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272626005128 active site 272626005129 HIGH motif; other site 272626005130 dimer interface [polypeptide binding]; other site 272626005131 KMSKS motif; other site 272626005132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626005133 RNA binding surface [nucleotide binding]; other site 272626005134 catabolite control protein A; Region: ccpA; TIGR01481 272626005135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626005136 DNA binding site [nucleotide binding] 272626005137 domain linker motif; other site 272626005138 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272626005139 dimerization interface [polypeptide binding]; other site 272626005140 effector binding site; other site 272626005141 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 272626005142 Chorismate mutase type II; Region: CM_2; cl00693 272626005143 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 272626005144 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272626005145 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 272626005146 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 272626005147 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 272626005148 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272626005149 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272626005150 dimer interface [polypeptide binding]; other site 272626005151 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272626005152 catalytic triad [active] 272626005153 peroxidatic and resolving cysteines [active] 272626005154 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272626005155 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272626005156 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272626005157 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272626005158 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272626005159 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272626005160 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272626005161 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272626005162 putative tRNA-binding site [nucleotide binding]; other site 272626005163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4848 272626005164 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626005165 catalytic residues [active] 272626005166 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272626005167 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272626005168 oligomer interface [polypeptide binding]; other site 272626005169 active site 272626005170 metal binding site [ion binding]; metal-binding site 272626005171 Predicted small secreted protein [Function unknown]; Region: COG5584 272626005172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 272626005173 putative homodimer interface [polypeptide binding]; other site 272626005174 putative homotetramer interface [polypeptide binding]; other site 272626005175 putative allosteric switch controlling residues; other site 272626005176 putative metal binding site [ion binding]; other site 272626005177 putative homodimer-homodimer interface [polypeptide binding]; other site 272626005178 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272626005179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005180 S-adenosylmethionine binding site [chemical binding]; other site 272626005181 Phosphotransferase enzyme family; Region: APH; pfam01636 272626005182 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272626005183 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272626005184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626005185 putative substrate translocation pore; other site 272626005186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626005187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626005188 MarR family; Region: MarR; pfam01047 272626005189 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272626005190 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272626005191 homodimer interface [polypeptide binding]; other site 272626005192 substrate-cofactor binding pocket; other site 272626005193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005194 catalytic residue [active] 272626005195 dipeptidase PepV; Reviewed; Region: PRK07318 272626005196 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272626005197 active site 272626005198 metal binding site [ion binding]; metal-binding site 272626005199 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 272626005200 nudix motif; other site 272626005201 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272626005202 putative substrate binding site [chemical binding]; other site 272626005203 putative ATP binding site [chemical binding]; other site 272626005204 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272626005205 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272626005206 active site 272626005207 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272626005208 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272626005209 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272626005210 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272626005211 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272626005212 substrate binding site [chemical binding]; other site 272626005213 active site 272626005214 catalytic residues [active] 272626005215 heterodimer interface [polypeptide binding]; other site 272626005216 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272626005217 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272626005218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005219 catalytic residue [active] 272626005220 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272626005221 active site 272626005222 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272626005223 active site 272626005224 ribulose/triose binding site [chemical binding]; other site 272626005225 phosphate binding site [ion binding]; other site 272626005226 substrate (anthranilate) binding pocket [chemical binding]; other site 272626005227 product (indole) binding pocket [chemical binding]; other site 272626005228 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272626005229 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272626005230 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272626005231 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272626005232 Glutamine amidotransferase class-I; Region: GATase; pfam00117 272626005233 glutamine binding [chemical binding]; other site 272626005234 catalytic triad [active] 272626005235 anthranilate synthase component I; Provisional; Region: PRK13570 272626005236 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272626005237 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272626005238 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272626005239 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272626005240 putative catalytic cysteine [active] 272626005241 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272626005242 putative active site [active] 272626005243 metal binding site [ion binding]; metal-binding site 272626005244 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272626005245 dimer interface [polypeptide binding]; other site 272626005246 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626005247 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 272626005248 Walker A/P-loop; other site 272626005249 ATP binding site [chemical binding]; other site 272626005250 Q-loop/lid; other site 272626005251 ABC transporter signature motif; other site 272626005252 Walker B; other site 272626005253 D-loop; other site 272626005254 H-loop/switch region; other site 272626005255 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272626005256 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272626005257 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272626005258 putative dimer interface [polypeptide binding]; other site 272626005259 catalytic triad [active] 272626005260 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272626005261 aconitate hydratase; Validated; Region: PRK09277 272626005262 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272626005263 substrate binding site [chemical binding]; other site 272626005264 ligand binding site [chemical binding]; other site 272626005265 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272626005266 substrate binding site [chemical binding]; other site 272626005267 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626005268 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272626005269 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272626005270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626005271 ATP binding site [chemical binding]; other site 272626005272 putative Mg++ binding site [ion binding]; other site 272626005273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626005274 nucleotide binding region [chemical binding]; other site 272626005275 ATP-binding site [chemical binding]; other site 272626005276 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272626005277 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272626005278 Walker A/P-loop; other site 272626005279 ATP binding site [chemical binding]; other site 272626005280 Q-loop/lid; other site 272626005281 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 272626005282 ABC transporter signature motif; other site 272626005283 Walker B; other site 272626005284 D-loop; other site 272626005285 H-loop/switch region; other site 272626005286 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272626005287 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272626005288 active site 272626005289 metal binding site [ion binding]; metal-binding site 272626005290 DNA binding site [nucleotide binding] 272626005291 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272626005292 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272626005293 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272626005294 putative acyl-acceptor binding pocket; other site 272626005295 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 272626005296 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626005297 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626005298 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272626005299 Walker A/P-loop; other site 272626005300 ATP binding site [chemical binding]; other site 272626005301 Q-loop/lid; other site 272626005302 ABC transporter signature motif; other site 272626005303 Walker B; other site 272626005304 D-loop; other site 272626005305 H-loop/switch region; other site 272626005306 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272626005307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626005308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626005309 Walker A/P-loop; other site 272626005310 ATP binding site [chemical binding]; other site 272626005311 Q-loop/lid; other site 272626005312 ABC transporter signature motif; other site 272626005313 Walker B; other site 272626005314 D-loop; other site 272626005315 H-loop/switch region; other site 272626005316 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272626005317 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272626005318 active site 272626005319 active site 272626005320 VanZ like family; Region: VanZ; cl01971 272626005321 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 272626005322 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 272626005323 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272626005324 amidase catalytic site [active] 272626005325 Zn binding residues [ion binding]; other site 272626005326 substrate binding site [chemical binding]; other site 272626005327 Small integral membrane protein [Function unknown]; Region: COG5546 272626005328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626005329 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 272626005330 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 272626005331 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 272626005332 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272626005333 Peptidase family M23; Region: Peptidase_M23; pfam01551 272626005334 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 272626005335 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 272626005336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 272626005337 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 272626005338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 272626005339 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 272626005340 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 272626005341 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 272626005342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 272626005343 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 272626005344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 272626005345 Terminase-like family; Region: Terminase_6; pfam03237 272626005346 Phage-related terminase [General function prediction only]; Region: COG5362 272626005347 Uncharacterized conserved protein [Function unknown]; Region: COG5484 272626005348 Phage terminase small subunit; Region: Phage_terminase; pfam10668 272626005349 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272626005350 ParB-like nuclease domain; Region: ParBc; pfam02195 272626005351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005352 S-adenosylmethionine binding site [chemical binding]; other site 272626005353 DNA methylase; Region: N6_N4_Mtase; cl17433 272626005354 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 272626005355 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272626005356 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 272626005357 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272626005358 Protein of unknown function (DUF968); Region: DUF968; pfam06147 272626005359 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 272626005360 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 272626005361 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272626005362 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626005363 Int/Topo IB signature motif; other site 272626005364 PcfJ-like protein; Region: PcfJ; pfam14284 272626005365 PcfK-like protein; Region: PcfK; pfam14058 272626005366 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 272626005367 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 272626005368 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272626005369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626005370 Walker A motif; other site 272626005371 ATP binding site [chemical binding]; other site 272626005372 Walker B motif; other site 272626005373 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 272626005374 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272626005375 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272626005376 phage recombination protein Bet; Region: bet_lambda; TIGR01913 272626005377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626005378 AAA domain; Region: AAA_23; pfam13476 272626005379 Walker A/P-loop; other site 272626005380 ATP binding site [chemical binding]; other site 272626005381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626005382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626005383 non-specific DNA binding site [nucleotide binding]; other site 272626005384 salt bridge; other site 272626005385 sequence-specific DNA binding site [nucleotide binding]; other site 272626005386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626005387 non-specific DNA binding site [nucleotide binding]; other site 272626005388 salt bridge; other site 272626005389 sequence-specific DNA binding site [nucleotide binding]; other site 272626005390 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 272626005391 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272626005392 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272626005393 active site 272626005394 catalytic residues [active] 272626005395 DNA binding site [nucleotide binding] 272626005396 Int/Topo IB signature motif; other site 272626005397 elongation factor Ts; Provisional; Region: tsf; PRK09377 272626005398 UBA/TS-N domain; Region: UBA; pfam00627 272626005399 Elongation factor TS; Region: EF_TS; pfam00889 272626005400 Elongation factor TS; Region: EF_TS; pfam00889 272626005401 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272626005402 rRNA interaction site [nucleotide binding]; other site 272626005403 S8 interaction site; other site 272626005404 putative laminin-1 binding site; other site 272626005405 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 272626005406 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272626005407 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272626005408 HIGH motif; other site 272626005409 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272626005410 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272626005411 active site 272626005412 KMSKS motif; other site 272626005413 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272626005414 tRNA binding surface [nucleotide binding]; other site 272626005415 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 272626005416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272626005417 FeS/SAM binding site; other site 272626005418 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272626005419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005420 S-adenosylmethionine binding site [chemical binding]; other site 272626005421 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 272626005422 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272626005423 active site 272626005424 dimer interface [polypeptide binding]; other site 272626005425 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272626005426 Ligand Binding Site [chemical binding]; other site 272626005427 Molecular Tunnel; other site 272626005428 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272626005429 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272626005430 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272626005431 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272626005432 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272626005433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626005434 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272626005435 NAD binding site [chemical binding]; other site 272626005436 dimer interface [polypeptide binding]; other site 272626005437 substrate binding site [chemical binding]; other site 272626005438 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 272626005439 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 272626005440 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 272626005441 nudix motif; other site 272626005442 Uncharacterized conserved protein [Function unknown]; Region: COG0759 272626005443 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272626005444 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 272626005445 metal binding site [ion binding]; metal-binding site 272626005446 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 272626005447 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 272626005448 acyl-activating enzyme (AAE) consensus motif; other site 272626005449 putative AMP binding site [chemical binding]; other site 272626005450 putative active site [active] 272626005451 putative CoA binding site [chemical binding]; other site 272626005452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272626005453 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272626005454 substrate binding site [chemical binding]; other site 272626005455 oxyanion hole (OAH) forming residues; other site 272626005456 trimer interface [polypeptide binding]; other site 272626005457 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626005458 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 272626005459 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272626005460 TAP-like protein; Region: Abhydrolase_4; pfam08386 272626005461 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 272626005462 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272626005463 dimer interface [polypeptide binding]; other site 272626005464 tetramer interface [polypeptide binding]; other site 272626005465 PYR/PP interface [polypeptide binding]; other site 272626005466 TPP binding site [chemical binding]; other site 272626005467 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272626005468 TPP-binding site; other site 272626005469 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 272626005470 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272626005471 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 272626005472 UbiA prenyltransferase family; Region: UbiA; pfam01040 272626005473 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 272626005474 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272626005475 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272626005476 FAD binding site [chemical binding]; other site 272626005477 cystathionine beta-lyase; Provisional; Region: PRK08064 272626005478 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272626005479 homodimer interface [polypeptide binding]; other site 272626005480 substrate-cofactor binding pocket; other site 272626005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005482 catalytic residue [active] 272626005483 cystathionine gamma-synthase; Reviewed; Region: PRK08247 272626005484 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272626005485 homodimer interface [polypeptide binding]; other site 272626005486 substrate-cofactor binding pocket; other site 272626005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005488 catalytic residue [active] 272626005489 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272626005490 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272626005491 THF binding site; other site 272626005492 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272626005493 substrate binding site [chemical binding]; other site 272626005494 THF binding site; other site 272626005495 zinc-binding site [ion binding]; other site 272626005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626005497 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626005498 putative substrate translocation pore; other site 272626005499 ferric uptake regulator; Provisional; Region: fur; PRK09462 272626005500 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272626005501 metal binding site 2 [ion binding]; metal-binding site 272626005502 putative DNA binding helix; other site 272626005503 metal binding site 1 [ion binding]; metal-binding site 272626005504 dimer interface [polypeptide binding]; other site 272626005505 structural Zn2+ binding site [ion binding]; other site 272626005506 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 272626005507 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272626005508 NAD binding site [chemical binding]; other site 272626005509 ligand binding site [chemical binding]; other site 272626005510 catalytic site [active] 272626005511 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 272626005512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272626005513 inhibitor-cofactor binding pocket; inhibition site 272626005514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626005515 catalytic residue [active] 272626005516 Predicted membrane protein [Function unknown]; Region: COG4129 272626005517 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272626005518 hypothetical protein; Provisional; Region: PRK13662 272626005519 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 272626005520 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 272626005521 putative NAD(P) binding site [chemical binding]; other site 272626005522 active site 272626005523 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272626005524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272626005525 minor groove reading motif; other site 272626005526 helix-hairpin-helix signature motif; other site 272626005527 substrate binding pocket [chemical binding]; other site 272626005528 active site 272626005529 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272626005530 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272626005531 DNA binding and oxoG recognition site [nucleotide binding] 272626005532 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 272626005533 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272626005534 trimer interface [polypeptide binding]; other site 272626005535 active site 272626005536 WVELL protein; Region: WVELL; pfam14043 272626005537 recombination regulator RecX; Provisional; Region: recX; PRK14135 272626005538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626005539 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272626005540 NAD(P) binding site [chemical binding]; other site 272626005541 active site 272626005542 Predicted integral membrane protein [Function unknown]; Region: COG0392 272626005543 Uncharacterized conserved protein [Function unknown]; Region: COG2898 272626005544 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 272626005545 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272626005546 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272626005547 Cation efflux family; Region: Cation_efflux; pfam01545 272626005548 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272626005549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626005550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272626005551 PAS domain; Region: PAS_9; pfam13426 272626005552 putative active site [active] 272626005553 heme pocket [chemical binding]; other site 272626005554 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272626005555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 272626005556 dimer interface [polypeptide binding]; other site 272626005557 putative CheW interface [polypeptide binding]; other site 272626005558 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 272626005559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272626005560 active site 272626005561 metal binding site [ion binding]; metal-binding site 272626005562 Beta-lactamase; Region: Beta-lactamase; pfam00144 272626005563 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272626005564 similar to excinuclease ABC (subunit A) (truncated, C-terminal end) 272626005565 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272626005566 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 272626005567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626005568 ABC transporter signature motif; other site 272626005569 Walker B; other site 272626005570 D-loop; other site 272626005571 H-loop/switch region; other site 272626005572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626005573 Walker A/P-loop; other site 272626005574 ATP binding site [chemical binding]; other site 272626005575 Q-loop/lid; other site 272626005576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626005577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626005578 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 272626005579 TRAM domain; Region: TRAM; cl01282 272626005580 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272626005581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005582 S-adenosylmethionine binding site [chemical binding]; other site 272626005583 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 272626005584 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272626005585 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272626005586 Substrate-binding site [chemical binding]; other site 272626005587 Substrate specificity [chemical binding]; other site 272626005588 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272626005589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 272626005590 Aminoglycoside N3'-acetyltransferase [Defense mechanisms]; Region: COG2746 272626005591 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272626005592 active site 272626005593 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272626005594 flavodoxin, short chain; Region: flav_short; TIGR01753 272626005595 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 272626005596 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 272626005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626005598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626005599 putative substrate translocation pore; other site 272626005600 rod-share determining protein MreBH; Provisional; Region: PRK13929 272626005601 MreB and similar proteins; Region: MreB_like; cd10225 272626005602 nucleotide binding site [chemical binding]; other site 272626005603 Mg binding site [ion binding]; other site 272626005604 putative protofilament interaction site [polypeptide binding]; other site 272626005605 RodZ interaction site [polypeptide binding]; other site 272626005606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272626005607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005608 S-adenosylmethionine binding site [chemical binding]; other site 272626005609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626005610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626005611 Uncharacterized conserved protein [Function unknown]; Region: COG4748 272626005612 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272626005613 Uncharacterized conserved protein [Function unknown]; Region: COG3589 272626005614 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272626005615 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626005616 methionine cluster; other site 272626005617 active site 272626005618 phosphorylation site [posttranslational modification] 272626005619 metal binding site [ion binding]; metal-binding site 272626005620 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626005621 active site 272626005622 P-loop; other site 272626005623 phosphorylation site [posttranslational modification] 272626005624 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272626005625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626005626 Walker A motif; other site 272626005627 ATP binding site [chemical binding]; other site 272626005628 Walker B motif; other site 272626005629 arginine finger; other site 272626005630 Transcriptional antiterminator [Transcription]; Region: COG3933 272626005631 PRD domain; Region: PRD; pfam00874 272626005632 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626005633 active pocket/dimerization site; other site 272626005634 active site 272626005635 phosphorylation site [posttranslational modification] 272626005636 PRD domain; Region: PRD; pfam00874 272626005637 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272626005638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272626005639 ATP binding site [chemical binding]; other site 272626005640 putative Mg++ binding site [ion binding]; other site 272626005641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626005642 nucleotide binding region [chemical binding]; other site 272626005643 ATP-binding site [chemical binding]; other site 272626005644 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272626005645 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626005646 Walker A/P-loop; other site 272626005647 ATP binding site [chemical binding]; other site 272626005648 Q-loop/lid; other site 272626005649 ABC transporter signature motif; other site 272626005650 Walker B; other site 272626005651 D-loop; other site 272626005652 H-loop/switch region; other site 272626005653 Predicted transcriptional regulators [Transcription]; Region: COG1725 272626005654 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626005655 DNA-binding site [nucleotide binding]; DNA binding site 272626005656 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626005657 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626005658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626005659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626005660 DNA binding site [nucleotide binding] 272626005661 domain linker motif; other site 272626005662 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272626005663 dimerization interface [polypeptide binding]; other site 272626005664 ligand binding site [chemical binding]; other site 272626005665 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 272626005666 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 272626005667 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 272626005668 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 272626005669 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626005670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626005671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626005672 dimer interface [polypeptide binding]; other site 272626005673 conserved gate region; other site 272626005674 putative PBP binding loops; other site 272626005675 ABC-ATPase subunit interface; other site 272626005676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626005677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626005678 dimer interface [polypeptide binding]; other site 272626005679 conserved gate region; other site 272626005680 putative PBP binding loops; other site 272626005681 ABC-ATPase subunit interface; other site 272626005682 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 272626005683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272626005684 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272626005685 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272626005686 active site 272626005687 dimer interface [polypeptide binding]; other site 272626005688 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272626005689 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272626005690 active site 272626005691 FMN binding site [chemical binding]; other site 272626005692 substrate binding site [chemical binding]; other site 272626005693 3Fe-4S cluster binding site [ion binding]; other site 272626005694 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272626005695 domain interface; other site 272626005696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626005697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626005698 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272626005699 putative dimerization interface [polypeptide binding]; other site 272626005700 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272626005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626005702 Coenzyme A binding pocket [chemical binding]; other site 272626005703 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272626005704 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272626005705 putative active site [active] 272626005706 metal binding site [ion binding]; metal-binding site 272626005707 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272626005708 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272626005709 substrate binding pocket [chemical binding]; other site 272626005710 membrane-bound complex binding site; other site 272626005711 hinge residues; other site 272626005712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626005713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626005714 Walker A/P-loop; other site 272626005715 ATP binding site [chemical binding]; other site 272626005716 Q-loop/lid; other site 272626005717 ABC transporter signature motif; other site 272626005718 Walker B; other site 272626005719 D-loop; other site 272626005720 H-loop/switch region; other site 272626005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626005722 dimer interface [polypeptide binding]; other site 272626005723 conserved gate region; other site 272626005724 putative PBP binding loops; other site 272626005725 ABC-ATPase subunit interface; other site 272626005726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272626005727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626005728 dimer interface [polypeptide binding]; other site 272626005729 phosphorylation site [posttranslational modification] 272626005730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626005731 ATP binding site [chemical binding]; other site 272626005732 Mg2+ binding site [ion binding]; other site 272626005733 G-X-G motif; other site 272626005734 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272626005735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272626005736 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272626005737 active site 272626005738 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 272626005739 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272626005740 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 272626005741 putative NAD(P) binding site [chemical binding]; other site 272626005742 active site 272626005743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626005744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626005745 active site 272626005746 phosphorylation site [posttranslational modification] 272626005747 intermolecular recognition site; other site 272626005748 dimerization interface [polypeptide binding]; other site 272626005749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626005750 DNA binding site [nucleotide binding] 272626005751 FtsX-like permease family; Region: FtsX; pfam02687 272626005752 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272626005753 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626005754 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626005755 Walker A/P-loop; other site 272626005756 ATP binding site [chemical binding]; other site 272626005757 Q-loop/lid; other site 272626005758 ABC transporter signature motif; other site 272626005759 Walker B; other site 272626005760 D-loop; other site 272626005761 H-loop/switch region; other site 272626005762 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272626005763 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272626005764 ADP binding site [chemical binding]; other site 272626005765 magnesium binding site [ion binding]; other site 272626005766 putative shikimate binding site; other site 272626005767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 272626005768 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272626005769 TRAM domain; Region: TRAM; pfam01938 272626005770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626005771 S-adenosylmethionine binding site [chemical binding]; other site 272626005772 putative lipid kinase; Reviewed; Region: PRK13337 272626005773 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272626005774 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272626005775 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272626005776 GatB domain; Region: GatB_Yqey; pfam02637 272626005777 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272626005778 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272626005779 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272626005780 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 272626005781 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 272626005782 putative dimer interface [polypeptide binding]; other site 272626005783 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 272626005784 putative dimer interface [polypeptide binding]; other site 272626005785 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272626005786 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272626005787 nucleotide binding pocket [chemical binding]; other site 272626005788 K-X-D-G motif; other site 272626005789 catalytic site [active] 272626005790 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272626005791 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272626005792 Dimer interface [polypeptide binding]; other site 272626005793 BRCT sequence motif; other site 272626005794 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272626005795 Part of AAA domain; Region: AAA_19; pfam13245 272626005796 Family description; Region: UvrD_C_2; pfam13538 272626005797 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 272626005798 PcrB family; Region: PcrB; pfam01884 272626005799 substrate binding site [chemical binding]; other site 272626005800 putative active site [active] 272626005801 dimer interface [polypeptide binding]; other site 272626005802 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 272626005803 Na2 binding site [ion binding]; other site 272626005804 putative substrate binding site 1 [chemical binding]; other site 272626005805 Na binding site 1 [ion binding]; other site 272626005806 putative substrate binding site 2 [chemical binding]; other site 272626005807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 272626005808 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272626005809 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272626005810 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272626005811 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272626005812 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272626005813 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272626005814 purine monophosphate binding site [chemical binding]; other site 272626005815 dimer interface [polypeptide binding]; other site 272626005816 putative catalytic residues [active] 272626005817 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272626005818 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272626005819 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 272626005820 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272626005821 active site 272626005822 substrate binding site [chemical binding]; other site 272626005823 cosubstrate binding site; other site 272626005824 catalytic site [active] 272626005825 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272626005826 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272626005827 dimerization interface [polypeptide binding]; other site 272626005828 putative ATP binding site [chemical binding]; other site 272626005829 amidophosphoribosyltransferase; Provisional; Region: PRK06781 272626005830 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272626005831 active site 272626005832 tetramer interface [polypeptide binding]; other site 272626005833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626005834 active site 272626005835 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272626005836 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272626005837 dimerization interface [polypeptide binding]; other site 272626005838 ATP binding site [chemical binding]; other site 272626005839 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272626005840 dimerization interface [polypeptide binding]; other site 272626005841 ATP binding site [chemical binding]; other site 272626005842 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272626005843 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272626005844 putative active site [active] 272626005845 catalytic triad [active] 272626005846 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 272626005847 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272626005848 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272626005849 ATP binding site [chemical binding]; other site 272626005850 active site 272626005851 substrate binding site [chemical binding]; other site 272626005852 adenylosuccinate lyase; Provisional; Region: PRK07492 272626005853 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272626005854 tetramer interface [polypeptide binding]; other site 272626005855 active site 272626005856 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272626005857 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272626005858 NAD binding site [chemical binding]; other site 272626005859 ATP-grasp domain; Region: ATP-grasp; pfam02222 272626005860 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272626005861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 272626005862 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626005863 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272626005864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626005865 Zn2+ binding site [ion binding]; other site 272626005866 Mg2+ binding site [ion binding]; other site 272626005867 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272626005868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272626005869 Walker A/P-loop; other site 272626005870 ATP binding site [chemical binding]; other site 272626005871 Q-loop/lid; other site 272626005872 ABC transporter signature motif; other site 272626005873 Walker B; other site 272626005874 D-loop; other site 272626005875 H-loop/switch region; other site 272626005876 peptidase T; Region: peptidase-T; TIGR01882 272626005877 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272626005878 metal binding site [ion binding]; metal-binding site 272626005879 dimer interface [polypeptide binding]; other site 272626005880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 272626005881 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272626005882 active site 272626005883 putative catalytic site [active] 272626005884 DNA binding site [nucleotide binding] 272626005885 putative phosphate binding site [ion binding]; other site 272626005886 metal binding site A [ion binding]; metal-binding site 272626005887 AP binding site [nucleotide binding]; other site 272626005888 metal binding site B [ion binding]; metal-binding site 272626005889 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272626005890 23S rRNA binding site [nucleotide binding]; other site 272626005891 L21 binding site [polypeptide binding]; other site 272626005892 L13 binding site [polypeptide binding]; other site 272626005893 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272626005894 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272626005895 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272626005896 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272626005897 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272626005898 Predicted transcriptional regulators [Transcription]; Region: COG1733 272626005899 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272626005900 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 272626005901 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272626005902 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 272626005903 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272626005904 DNA binding residues [nucleotide binding] 272626005905 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272626005906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272626005907 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272626005908 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 272626005909 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 272626005910 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272626005911 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272626005912 RimM N-terminal domain; Region: RimM; pfam01782 272626005913 PRC-barrel domain; Region: PRC; pfam05239 272626005914 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 272626005915 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 272626005916 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272626005917 catalytic triad [active] 272626005918 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 272626005919 KH domain; Region: KH_4; pfam13083 272626005920 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272626005921 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 272626005922 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272626005923 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272626005924 signal recognition particle protein; Provisional; Region: PRK10867 272626005925 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272626005926 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272626005927 P loop; other site 272626005928 GTP binding site [chemical binding]; other site 272626005929 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272626005930 putative DNA-binding protein; Validated; Region: PRK00118 272626005931 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 272626005932 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272626005933 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272626005934 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272626005935 P loop; other site 272626005936 GTP binding site [chemical binding]; other site 272626005937 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272626005938 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272626005939 Walker A/P-loop; other site 272626005940 ATP binding site [chemical binding]; other site 272626005941 Q-loop/lid; other site 272626005942 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272626005943 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 272626005944 linker region; other site 272626005945 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 272626005946 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272626005947 ABC transporter signature motif; other site 272626005948 Walker B; other site 272626005949 D-loop; other site 272626005950 H-loop/switch region; other site 272626005951 ribonuclease III; Reviewed; Region: rnc; PRK00102 272626005952 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272626005953 dimerization interface [polypeptide binding]; other site 272626005954 active site 272626005955 metal binding site [ion binding]; metal-binding site 272626005956 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272626005957 dsRNA binding site [nucleotide binding]; other site 272626005958 acyl carrier protein; Provisional; Region: acpP; PRK00982 272626005959 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272626005960 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272626005961 NAD(P) binding site [chemical binding]; other site 272626005962 homotetramer interface [polypeptide binding]; other site 272626005963 homodimer interface [polypeptide binding]; other site 272626005964 active site 272626005965 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272626005966 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272626005967 putative phosphate acyltransferase; Provisional; Region: PRK05331 272626005968 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 272626005969 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 272626005970 active site 2 [active] 272626005971 active site 1 [active] 272626005972 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272626005973 Y-family of DNA polymerases; Region: PolY; cl12025 272626005974 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272626005975 generic binding surface II; other site 272626005976 ssDNA binding site; other site 272626005977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626005978 ATP binding site [chemical binding]; other site 272626005979 putative Mg++ binding site [ion binding]; other site 272626005980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626005981 nucleotide binding region [chemical binding]; other site 272626005982 ATP-binding site [chemical binding]; other site 272626005983 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272626005984 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272626005985 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 272626005986 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272626005987 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 272626005988 putative L-serine binding site [chemical binding]; other site 272626005989 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272626005990 DAK2 domain; Region: Dak2; pfam02734 272626005991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272626005992 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272626005993 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272626005994 Thiamine pyrophosphokinase; Region: TPK; cd07995 272626005995 active site 272626005996 dimerization interface [polypeptide binding]; other site 272626005997 thiamine binding site [chemical binding]; other site 272626005998 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272626005999 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272626006000 substrate binding site [chemical binding]; other site 272626006001 hexamer interface [polypeptide binding]; other site 272626006002 metal binding site [ion binding]; metal-binding site 272626006003 GTPase RsgA; Reviewed; Region: PRK00098 272626006004 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272626006005 RNA binding site [nucleotide binding]; other site 272626006006 homodimer interface [polypeptide binding]; other site 272626006007 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272626006008 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272626006009 GTP/Mg2+ binding site [chemical binding]; other site 272626006010 G4 box; other site 272626006011 G1 box; other site 272626006012 Switch I region; other site 272626006013 G2 box; other site 272626006014 G3 box; other site 272626006015 Switch II region; other site 272626006016 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272626006017 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272626006018 active site 272626006019 ATP binding site [chemical binding]; other site 272626006020 substrate binding site [chemical binding]; other site 272626006021 activation loop (A-loop); other site 272626006022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272626006023 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272626006024 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272626006025 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272626006026 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272626006027 Protein phosphatase 2C; Region: PP2C; pfam00481 272626006028 active site 272626006029 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272626006030 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272626006031 putative RNA binding site [nucleotide binding]; other site 272626006032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626006033 S-adenosylmethionine binding site [chemical binding]; other site 272626006034 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272626006035 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272626006036 putative active site [active] 272626006037 substrate binding site [chemical binding]; other site 272626006038 putative cosubstrate binding site; other site 272626006039 catalytic site [active] 272626006040 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272626006041 substrate binding site [chemical binding]; other site 272626006042 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 272626006043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626006044 ATP binding site [chemical binding]; other site 272626006045 putative Mg++ binding site [ion binding]; other site 272626006046 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626006047 ATP-binding site [chemical binding]; other site 272626006048 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272626006049 Flavoprotein; Region: Flavoprotein; pfam02441 272626006050 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272626006051 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272626006052 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272626006053 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272626006054 catalytic site [active] 272626006055 G-X2-G-X-G-K; other site 272626006056 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 272626006057 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272626006058 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272626006059 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 272626006060 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272626006061 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 272626006062 putative NAD(P) binding site [chemical binding]; other site 272626006063 homodimer interface [polypeptide binding]; other site 272626006064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626006065 active site 272626006066 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272626006067 active site 272626006068 dimer interface [polypeptide binding]; other site 272626006069 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 272626006070 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272626006071 heterodimer interface [polypeptide binding]; other site 272626006072 active site 272626006073 FMN binding site [chemical binding]; other site 272626006074 homodimer interface [polypeptide binding]; other site 272626006075 substrate binding site [chemical binding]; other site 272626006076 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272626006077 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272626006078 FAD binding pocket [chemical binding]; other site 272626006079 FAD binding motif [chemical binding]; other site 272626006080 phosphate binding motif [ion binding]; other site 272626006081 beta-alpha-beta structure motif; other site 272626006082 NAD binding pocket [chemical binding]; other site 272626006083 Iron coordination center [ion binding]; other site 272626006084 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272626006085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272626006086 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272626006087 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272626006088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272626006089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272626006090 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272626006091 IMP binding site; other site 272626006092 dimer interface [polypeptide binding]; other site 272626006093 interdomain contacts; other site 272626006094 partial ornithine binding site; other site 272626006095 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272626006096 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272626006097 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272626006098 catalytic site [active] 272626006099 subunit interface [polypeptide binding]; other site 272626006100 dihydroorotase; Validated; Region: pyrC; PRK09357 272626006101 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272626006102 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272626006103 active site 272626006104 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272626006105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272626006106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272626006107 uracil transporter; Provisional; Region: PRK10720 272626006108 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272626006109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626006110 active site 272626006111 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 272626006112 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272626006113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626006114 RNA binding surface [nucleotide binding]; other site 272626006115 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272626006116 active site 272626006117 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272626006118 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272626006119 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272626006120 multidrug efflux protein; Reviewed; Region: PRK01766 272626006121 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272626006122 cation binding site [ion binding]; other site 272626006123 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272626006124 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272626006125 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272626006126 metal binding site [ion binding]; metal-binding site 272626006127 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272626006128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626006129 ABC-ATPase subunit interface; other site 272626006130 dimer interface [polypeptide binding]; other site 272626006131 putative PBP binding regions; other site 272626006132 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272626006133 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272626006134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626006135 MarR family; Region: MarR; pfam01047 272626006136 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272626006137 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272626006138 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272626006139 protein binding site [polypeptide binding]; other site 272626006140 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272626006141 Catalytic dyad [active] 272626006142 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272626006143 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272626006144 metal-binding site [ion binding] 272626006145 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272626006146 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272626006147 metal-binding site [ion binding] 272626006148 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626006149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626006150 active site 272626006151 motif I; other site 272626006152 motif II; other site 272626006153 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 272626006154 putative homodimer interface [polypeptide binding]; other site 272626006155 putative homotetramer interface [polypeptide binding]; other site 272626006156 allosteric switch controlling residues; other site 272626006157 putative metal binding site [ion binding]; other site 272626006158 putative homodimer-homodimer interface [polypeptide binding]; other site 272626006159 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 272626006160 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 272626006161 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 272626006162 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272626006163 hypothetical protein; Provisional; Region: PRK13672 272626006164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626006165 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626006166 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272626006167 SelR domain; Region: SelR; pfam01641 272626006168 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272626006169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 272626006170 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 272626006171 active site 272626006172 catalytic triad [active] 272626006173 oxyanion hole [active] 272626006174 EDD domain protein, DegV family; Region: DegV; TIGR00762 272626006175 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272626006176 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272626006177 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 272626006178 HTH domain; Region: HTH_11; pfam08279 272626006179 FOG: CBS domain [General function prediction only]; Region: COG0517 272626006180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 272626006181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 272626006182 pyruvate phosphate dikinase; Provisional; Region: PRK09279 272626006183 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272626006184 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272626006185 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272626006186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626006187 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 272626006188 Predicted membrane protein [Function unknown]; Region: COG4129 272626006189 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 272626006190 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 272626006191 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272626006192 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272626006193 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272626006194 active site 272626006195 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272626006196 substrate binding site [chemical binding]; other site 272626006197 metal binding site [ion binding]; metal-binding site 272626006198 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 272626006199 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272626006200 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272626006201 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272626006202 folate binding site [chemical binding]; other site 272626006203 NADP+ binding site [chemical binding]; other site 272626006204 thymidylate synthase; Region: thym_sym; TIGR03284 272626006205 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272626006206 dimerization interface [polypeptide binding]; other site 272626006207 active site 272626006208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272626006209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626006210 Walker A/P-loop; other site 272626006211 ATP binding site [chemical binding]; other site 272626006212 Q-loop/lid; other site 272626006213 ABC transporter signature motif; other site 272626006214 Walker B; other site 272626006215 D-loop; other site 272626006216 H-loop/switch region; other site 272626006217 ABC transporter; Region: ABC_tran_2; pfam12848 272626006218 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626006219 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 272626006220 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272626006221 Potassium binding sites [ion binding]; other site 272626006222 Cesium cation binding sites [ion binding]; other site 272626006223 manganese transport transcriptional regulator; Provisional; Region: PRK03902 272626006224 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272626006225 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272626006226 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272626006227 DNA-binding site [nucleotide binding]; DNA binding site 272626006228 RNA-binding motif; other site 272626006229 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 272626006230 RNA/DNA hybrid binding site [nucleotide binding]; other site 272626006231 active site 272626006232 5'-3' exonuclease; Region: 53EXOc; smart00475 272626006233 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272626006234 active site 272626006235 metal binding site 1 [ion binding]; metal-binding site 272626006236 putative 5' ssDNA interaction site; other site 272626006237 metal binding site 3; metal-binding site 272626006238 metal binding site 2 [ion binding]; metal-binding site 272626006239 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272626006240 putative DNA binding site [nucleotide binding]; other site 272626006241 putative metal binding site [ion binding]; other site 272626006242 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272626006243 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 272626006244 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 272626006245 putative active site [active] 272626006246 xanthine permease; Region: pbuX; TIGR03173 272626006247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626006248 active site 272626006249 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 272626006250 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272626006251 active site 272626006252 Zn binding site [ion binding]; other site 272626006253 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272626006254 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272626006255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272626006256 cell division protein GpsB; Provisional; Region: PRK14127 272626006257 DivIVA domain; Region: DivI1A_domain; TIGR03544 272626006258 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 272626006259 hypothetical protein; Provisional; Region: PRK13660 272626006260 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 272626006261 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 272626006262 Transglycosylase; Region: Transgly; pfam00912 272626006263 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272626006264 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272626006265 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272626006266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272626006267 minor groove reading motif; other site 272626006268 helix-hairpin-helix signature motif; other site 272626006269 substrate binding pocket [chemical binding]; other site 272626006270 active site 272626006271 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272626006272 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272626006273 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272626006274 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272626006275 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272626006276 putative dimer interface [polypeptide binding]; other site 272626006277 putative anticodon binding site; other site 272626006278 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272626006279 homodimer interface [polypeptide binding]; other site 272626006280 motif 1; other site 272626006281 motif 2; other site 272626006282 active site 272626006283 motif 3; other site 272626006284 aspartate aminotransferase; Provisional; Region: PRK05764 272626006285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626006286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626006287 homodimer interface [polypeptide binding]; other site 272626006288 catalytic residue [active] 272626006289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272626006290 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272626006291 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 272626006292 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272626006293 active site 272626006294 catalytic site [active] 272626006295 substrate binding site [chemical binding]; other site 272626006296 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 272626006297 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272626006298 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272626006299 tetramerization interface [polypeptide binding]; other site 272626006300 active site 272626006301 pantoate--beta-alanine ligase; Region: panC; TIGR00018 272626006302 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272626006303 active site 272626006304 ATP-binding site [chemical binding]; other site 272626006305 pantoate-binding site; other site 272626006306 HXXH motif; other site 272626006307 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272626006308 active site 272626006309 oligomerization interface [polypeptide binding]; other site 272626006310 metal binding site [ion binding]; metal-binding site 272626006311 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626006312 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272626006313 catalytic residues [active] 272626006314 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272626006315 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272626006316 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272626006317 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272626006318 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272626006319 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272626006320 active site 272626006321 NTP binding site [chemical binding]; other site 272626006322 metal binding triad [ion binding]; metal-binding site 272626006323 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272626006324 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272626006325 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 272626006326 active site 272626006327 dimer interfaces [polypeptide binding]; other site 272626006328 catalytic residues [active] 272626006329 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272626006330 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272626006331 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272626006332 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 272626006333 homodimer interface [polypeptide binding]; other site 272626006334 metal binding site [ion binding]; metal-binding site 272626006335 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272626006336 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626006337 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626006338 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626006339 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272626006340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272626006341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272626006342 metal binding site [ion binding]; metal-binding site 272626006343 active site 272626006344 I-site; other site 272626006345 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272626006346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272626006347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272626006348 metal binding site [ion binding]; metal-binding site 272626006349 active site 272626006350 I-site; other site 272626006351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272626006352 malate dehydrogenase; Provisional; Region: PRK13529 272626006353 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272626006354 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272626006355 NAD(P) binding pocket [chemical binding]; other site 272626006356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272626006357 Beta-lactamase; Region: Beta-lactamase; pfam00144 272626006358 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272626006359 Pyruvate formate lyase 1; Region: PFL1; cd01678 272626006360 coenzyme A binding site [chemical binding]; other site 272626006361 active site 272626006362 catalytic residues [active] 272626006363 glycine loop; other site 272626006364 HI0933-like protein; Region: HI0933_like; pfam03486 272626006365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626006366 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 272626006367 Predicted membrane protein [Function unknown]; Region: COG4347 272626006368 hypothetical protein; Provisional; Region: PRK03636 272626006369 UPF0302 domain; Region: UPF0302; pfam08864 272626006370 IDEAL domain; Region: IDEAL; pfam08858 272626006371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272626006372 binding surface 272626006373 TPR motif; other site 272626006374 TPR repeat; Region: TPR_11; pfam13414 272626006375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626006376 binding surface 272626006377 TPR motif; other site 272626006378 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272626006379 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272626006380 hinge; other site 272626006381 active site 272626006382 prephenate dehydrogenase; Validated; Region: PRK06545 272626006383 prephenate dehydrogenase; Validated; Region: PRK08507 272626006384 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 272626006385 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 272626006386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626006387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626006388 homodimer interface [polypeptide binding]; other site 272626006389 catalytic residue [active] 272626006390 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 272626006391 homotrimer interaction site [polypeptide binding]; other site 272626006392 active site 272626006393 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272626006394 active site 272626006395 dimer interface [polypeptide binding]; other site 272626006396 metal binding site [ion binding]; metal-binding site 272626006397 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272626006398 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272626006399 Tetramer interface [polypeptide binding]; other site 272626006400 active site 272626006401 FMN-binding site [chemical binding]; other site 272626006402 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272626006403 active site 272626006404 multimer interface [polypeptide binding]; other site 272626006405 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272626006406 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272626006407 substrate binding pocket [chemical binding]; other site 272626006408 chain length determination region; other site 272626006409 substrate-Mg2+ binding site; other site 272626006410 catalytic residues [active] 272626006411 aspartate-rich region 1; other site 272626006412 active site lid residues [active] 272626006413 aspartate-rich region 2; other site 272626006414 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 272626006415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626006416 S-adenosylmethionine binding site [chemical binding]; other site 272626006417 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 272626006418 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 272626006419 homodecamer interface [polypeptide binding]; other site 272626006420 GTP cyclohydrolase I; Provisional; Region: PLN03044 272626006421 active site 272626006422 putative catalytic site residues [active] 272626006423 zinc binding site [ion binding]; other site 272626006424 GTP-CH-I/GFRP interaction surface; other site 272626006425 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272626006426 IHF dimer interface [polypeptide binding]; other site 272626006427 IHF - DNA interface [nucleotide binding]; other site 272626006428 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272626006429 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272626006430 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272626006431 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272626006432 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272626006433 GTP-binding protein Der; Reviewed; Region: PRK00093 272626006434 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272626006435 G1 box; other site 272626006436 GTP/Mg2+ binding site [chemical binding]; other site 272626006437 Switch I region; other site 272626006438 G2 box; other site 272626006439 Switch II region; other site 272626006440 G3 box; other site 272626006441 G4 box; other site 272626006442 G5 box; other site 272626006443 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272626006444 G1 box; other site 272626006445 GTP/Mg2+ binding site [chemical binding]; other site 272626006446 Switch I region; other site 272626006447 G2 box; other site 272626006448 G3 box; other site 272626006449 Switch II region; other site 272626006450 G4 box; other site 272626006451 G5 box; other site 272626006452 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272626006453 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272626006454 RNA binding site [nucleotide binding]; other site 272626006455 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272626006456 RNA binding site [nucleotide binding]; other site 272626006457 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272626006458 RNA binding site [nucleotide binding]; other site 272626006459 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 272626006460 RNA binding site [nucleotide binding]; other site 272626006461 cytidylate kinase; Provisional; Region: cmk; PRK00023 272626006462 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272626006463 CMP-binding site; other site 272626006464 The sites determining sugar specificity; other site 272626006465 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272626006466 active site 272626006467 homotetramer interface [polypeptide binding]; other site 272626006468 homodimer interface [polypeptide binding]; other site 272626006469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626006470 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272626006471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626006472 ATP binding site [chemical binding]; other site 272626006473 putative Mg++ binding site [ion binding]; other site 272626006474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626006475 nucleotide binding region [chemical binding]; other site 272626006476 ATP-binding site [chemical binding]; other site 272626006477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 272626006478 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 272626006479 Predicted membrane protein [Function unknown]; Region: COG3601 272626006480 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272626006481 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272626006482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272626006483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626006484 dimerization interface [polypeptide binding]; other site 272626006485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626006486 dimer interface [polypeptide binding]; other site 272626006487 phosphorylation site [posttranslational modification] 272626006488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626006489 ATP binding site [chemical binding]; other site 272626006490 Mg2+ binding site [ion binding]; other site 272626006491 G-X-G motif; other site 272626006492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626006493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626006494 active site 272626006495 phosphorylation site [posttranslational modification] 272626006496 intermolecular recognition site; other site 272626006497 dimerization interface [polypeptide binding]; other site 272626006498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626006499 DNA binding site [nucleotide binding] 272626006500 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272626006501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626006502 RNA binding surface [nucleotide binding]; other site 272626006503 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272626006504 active site 272626006505 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 272626006506 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 272626006507 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272626006508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272626006509 active site 272626006510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272626006511 substrate binding site [chemical binding]; other site 272626006512 catalytic residues [active] 272626006513 dimer interface [polypeptide binding]; other site 272626006514 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272626006515 phosphopentomutase; Provisional; Region: PRK05362 272626006516 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272626006517 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272626006518 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272626006519 active site 272626006520 Int/Topo IB signature motif; other site 272626006521 ferric uptake regulator; Provisional; Region: fur; PRK09462 272626006522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272626006523 metal binding site 2 [ion binding]; metal-binding site 272626006524 putative DNA binding helix; other site 272626006525 metal binding site 1 [ion binding]; metal-binding site 272626006526 dimer interface [polypeptide binding]; other site 272626006527 structural Zn2+ binding site [ion binding]; other site 272626006528 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272626006529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626006530 ABC-ATPase subunit interface; other site 272626006531 dimer interface [polypeptide binding]; other site 272626006532 putative PBP binding regions; other site 272626006533 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272626006534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626006535 ABC-ATPase subunit interface; other site 272626006536 dimer interface [polypeptide binding]; other site 272626006537 putative PBP binding regions; other site 272626006538 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 272626006539 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272626006540 putative ligand binding residues [chemical binding]; other site 272626006541 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272626006542 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272626006543 Walker A/P-loop; other site 272626006544 ATP binding site [chemical binding]; other site 272626006545 Q-loop/lid; other site 272626006546 ABC transporter signature motif; other site 272626006547 Walker B; other site 272626006548 D-loop; other site 272626006549 H-loop/switch region; other site 272626006550 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272626006551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626006552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626006553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626006554 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272626006555 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272626006556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626006557 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626006558 Walker A/P-loop; other site 272626006559 ATP binding site [chemical binding]; other site 272626006560 Q-loop/lid; other site 272626006561 ABC transporter signature motif; other site 272626006562 Walker B; other site 272626006563 D-loop; other site 272626006564 H-loop/switch region; other site 272626006565 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 272626006566 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272626006567 dimer interface [polypeptide binding]; other site 272626006568 ADP-ribose binding site [chemical binding]; other site 272626006569 active site 272626006570 nudix motif; other site 272626006571 metal binding site [ion binding]; metal-binding site 272626006572 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 272626006573 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 272626006574 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272626006575 active site 272626006576 DNA polymerase IV; Validated; Region: PRK02406 272626006577 DNA binding site [nucleotide binding] 272626006578 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272626006579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272626006580 NAD(P) binding site [chemical binding]; other site 272626006581 active site 272626006582 ribonuclease Z; Region: RNase_Z; TIGR02651 272626006583 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272626006584 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272626006585 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272626006586 Uncharacterized conserved protein [Function unknown]; Region: COG5506 272626006587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272626006588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626006589 Coenzyme A binding pocket [chemical binding]; other site 272626006590 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 272626006591 6-phosphogluconate dehydratase; Region: edd; TIGR01196 272626006592 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 272626006593 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272626006594 PYR/PP interface [polypeptide binding]; other site 272626006595 dimer interface [polypeptide binding]; other site 272626006596 TPP binding site [chemical binding]; other site 272626006597 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272626006598 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272626006599 TPP-binding site [chemical binding]; other site 272626006600 dimer interface [polypeptide binding]; other site 272626006601 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272626006602 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272626006603 putative valine binding site [chemical binding]; other site 272626006604 dimer interface [polypeptide binding]; other site 272626006605 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272626006606 ketol-acid reductoisomerase; Provisional; Region: PRK05479 272626006607 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272626006608 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272626006609 2-isopropylmalate synthase; Validated; Region: PRK00915 272626006610 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272626006611 active site 272626006612 catalytic residues [active] 272626006613 metal binding site [ion binding]; metal-binding site 272626006614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 272626006615 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272626006616 tartrate dehydrogenase; Region: TTC; TIGR02089 272626006617 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272626006618 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272626006619 substrate binding site [chemical binding]; other site 272626006620 ligand binding site [chemical binding]; other site 272626006621 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 272626006622 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272626006623 substrate binding site [chemical binding]; other site 272626006624 threonine dehydratase; Validated; Region: PRK08639 272626006625 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272626006626 tetramer interface [polypeptide binding]; other site 272626006627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626006628 catalytic residue [active] 272626006629 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272626006630 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 272626006631 NlpC/P60 family; Region: NLPC_P60; pfam00877 272626006632 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006633 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006634 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 272626006635 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006636 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006637 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006638 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 272626006639 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006640 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006641 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006642 Bacterial SH3 domain; Region: SH3_3; pfam08239 272626006643 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 272626006644 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272626006645 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272626006646 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272626006647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626006648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626006649 DNA binding site [nucleotide binding] 272626006650 domain linker motif; other site 272626006651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272626006652 dimerization interface [polypeptide binding]; other site 272626006653 ligand binding site [chemical binding]; other site 272626006654 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272626006655 intersubunit interface [polypeptide binding]; other site 272626006656 active site 272626006657 catalytic residue [active] 272626006658 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272626006659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272626006660 DNA binding residues [nucleotide binding] 272626006661 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272626006662 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272626006663 active pocket/dimerization site; other site 272626006664 active site 272626006665 phosphorylation site [posttranslational modification] 272626006666 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272626006667 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 272626006668 putative active site [active] 272626006669 SIS domain; Region: SIS; pfam01380 272626006670 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 272626006671 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272626006672 dimer interface [polypeptide binding]; other site 272626006673 active site 272626006674 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272626006675 dimer interface [polypeptide binding]; other site 272626006676 active site 272626006677 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272626006678 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 272626006679 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272626006680 active site 272626006681 phosphorylation site [posttranslational modification] 272626006682 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626006683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626006684 DNA-binding site [nucleotide binding]; DNA binding site 272626006685 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272626006686 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272626006687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626006688 DNA-binding site [nucleotide binding]; DNA binding site 272626006689 UTRA domain; Region: UTRA; pfam07702 272626006690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626006691 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626006692 active site 272626006693 catalytic tetrad [active] 272626006694 acetolactate synthase; Reviewed; Region: PRK08617 272626006695 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272626006696 PYR/PP interface [polypeptide binding]; other site 272626006697 dimer interface [polypeptide binding]; other site 272626006698 TPP binding site [chemical binding]; other site 272626006699 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272626006700 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 272626006701 TPP-binding site [chemical binding]; other site 272626006702 dimer interface [polypeptide binding]; other site 272626006703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626006704 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626006705 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 272626006706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626006708 ABC-ATPase subunit interface; other site 272626006709 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272626006710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626006711 dimer interface [polypeptide binding]; other site 272626006712 conserved gate region; other site 272626006713 ABC-ATPase subunit interface; other site 272626006714 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 272626006715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626006716 active site 272626006717 phosphorylation site [posttranslational modification] 272626006718 intermolecular recognition site; other site 272626006719 dimerization interface [polypeptide binding]; other site 272626006720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626006721 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272626006722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626006723 dimerization interface [polypeptide binding]; other site 272626006724 Histidine kinase; Region: His_kinase; pfam06580 272626006725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626006726 ATP binding site [chemical binding]; other site 272626006727 Mg2+ binding site [ion binding]; other site 272626006728 G-X-G motif; other site 272626006729 Predicted integral membrane protein [Function unknown]; Region: COG5578 272626006730 Uncharacterized conserved protein [Function unknown]; Region: COG3538 272626006731 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 272626006732 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272626006733 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 272626006734 active site 272626006735 metal binding site [ion binding]; metal-binding site 272626006736 homodimer interface [polypeptide binding]; other site 272626006737 catalytic site [active] 272626006738 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272626006739 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 272626006740 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 272626006741 active site 272626006742 catalytic site [active] 272626006743 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 272626006744 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272626006745 DNA-binding site [nucleotide binding]; DNA binding site 272626006746 RNA-binding motif; other site 272626006747 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272626006748 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272626006749 active site 272626006750 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272626006751 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272626006752 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272626006753 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272626006754 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272626006755 active site 272626006756 HIGH motif; other site 272626006757 nucleotide binding site [chemical binding]; other site 272626006758 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272626006759 active site 272626006760 KMSKS motif; other site 272626006761 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272626006762 tRNA binding surface [nucleotide binding]; other site 272626006763 anticodon binding site; other site 272626006764 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272626006765 DivIVA protein; Region: DivIVA; pfam05103 272626006766 DivIVA domain; Region: DivI1A_domain; TIGR03544 272626006767 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 272626006768 HTH domain; Region: HTH_11; pfam08279 272626006769 3H domain; Region: 3H; pfam02829 272626006770 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272626006771 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272626006772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626006773 catalytic residue [active] 272626006774 L-aspartate oxidase; Provisional; Region: PRK08071 272626006775 L-aspartate oxidase; Provisional; Region: PRK06175 272626006776 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272626006777 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 272626006778 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272626006779 dimerization interface [polypeptide binding]; other site 272626006780 active site 272626006781 quinolinate synthetase; Provisional; Region: PRK09375 272626006782 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272626006783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626006784 RNA binding surface [nucleotide binding]; other site 272626006785 YGGT family; Region: YGGT; pfam02325 272626006786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272626006787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 272626006788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272626006789 catalytic residue [active] 272626006790 cell division protein FtsZ; Validated; Region: PRK09330 272626006791 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272626006792 nucleotide binding site [chemical binding]; other site 272626006793 SulA interaction site; other site 272626006794 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272626006795 Cell division protein FtsA; Region: FtsA; smart00842 272626006796 Cell division protein FtsA; Region: FtsA; pfam14450 272626006797 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 272626006798 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272626006799 Cell division protein FtsQ; Region: FtsQ; pfam03799 272626006800 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272626006801 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272626006802 active site 272626006803 homodimer interface [polypeptide binding]; other site 272626006804 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272626006805 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272626006806 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272626006807 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272626006808 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272626006809 Mg++ binding site [ion binding]; other site 272626006810 putative catalytic motif [active] 272626006811 putative substrate binding site [chemical binding]; other site 272626006812 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272626006813 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272626006814 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272626006815 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272626006816 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272626006817 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272626006818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272626006819 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272626006820 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272626006821 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 272626006822 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 272626006823 MraW methylase family; Region: Methyltransf_5; pfam01795 272626006824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 272626006825 MraZ protein; Region: MraZ; pfam02381 272626006826 MraZ protein; Region: MraZ; pfam02381 272626006827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626006828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626006829 putative substrate translocation pore; other site 272626006830 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 272626006831 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 272626006832 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 272626006833 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 272626006834 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272626006835 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272626006836 Muconolactone delta-isomerase; Region: MIase; cl01992 272626006837 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272626006838 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272626006839 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 272626006840 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 272626006841 hypothetical protein; Provisional; Region: PRK13670 272626006842 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272626006843 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272626006844 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272626006845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626006846 Walker A/P-loop; other site 272626006847 ATP binding site [chemical binding]; other site 272626006848 Q-loop/lid; other site 272626006849 ABC transporter signature motif; other site 272626006850 Walker B; other site 272626006851 D-loop; other site 272626006852 H-loop/switch region; other site 272626006853 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272626006854 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 272626006855 protein binding site [polypeptide binding]; other site 272626006856 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272626006857 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272626006858 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272626006859 active site 272626006860 (T/H)XGH motif; other site 272626006861 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 272626006862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626006863 S-adenosylmethionine binding site [chemical binding]; other site 272626006864 hypothetical protein; Provisional; Region: PRK02886 272626006865 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 272626006866 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272626006867 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272626006868 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 272626006869 UbiA prenyltransferase family; Region: UbiA; pfam01040 272626006870 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272626006871 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 272626006872 Ion transport protein; Region: Ion_trans; pfam00520 272626006873 Ion channel; Region: Ion_trans_2; pfam07885 272626006874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 272626006875 MOSC domain; Region: MOSC; pfam03473 272626006876 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 272626006877 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 272626006878 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 272626006879 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 272626006880 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272626006881 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272626006882 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272626006883 ring oligomerisation interface [polypeptide binding]; other site 272626006884 ATP/Mg binding site [chemical binding]; other site 272626006885 stacking interactions; other site 272626006886 hinge regions; other site 272626006887 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272626006888 oligomerisation interface [polypeptide binding]; other site 272626006889 mobile loop; other site 272626006890 roof hairpin; other site 272626006891 CAAX protease self-immunity; Region: Abi; pfam02517 272626006892 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 272626006893 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272626006894 CoA binding domain; Region: CoA_binding; pfam02629 272626006895 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272626006896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626006897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626006898 ABC transporter; Region: ABC_tran_2; pfam12848 272626006899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626006900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626006901 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272626006902 UGMP family protein; Validated; Region: PRK09604 272626006903 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272626006904 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272626006905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626006906 Coenzyme A binding pocket [chemical binding]; other site 272626006907 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272626006908 Glycoprotease family; Region: Peptidase_M22; pfam00814 272626006909 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272626006910 camphor resistance protein CrcB; Provisional; Region: PRK14214 272626006911 camphor resistance protein CrcB; Provisional; Region: PRK14231 272626006912 Uncharacterized conserved protein [Function unknown]; Region: COG4832 272626006913 Phosphotransferase enzyme family; Region: APH; pfam01636 272626006914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272626006915 active site 272626006916 substrate binding site [chemical binding]; other site 272626006917 ATP binding site [chemical binding]; other site 272626006918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626006919 non-specific DNA binding site [nucleotide binding]; other site 272626006920 salt bridge; other site 272626006921 sequence-specific DNA binding site [nucleotide binding]; other site 272626006922 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272626006923 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272626006924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626006925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626006926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272626006927 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272626006928 substrate binding pocket [chemical binding]; other site 272626006929 argininosuccinate synthase; Provisional; Region: PRK13820 272626006930 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272626006931 ANP binding site [chemical binding]; other site 272626006932 Substrate Binding Site II [chemical binding]; other site 272626006933 Substrate Binding Site I [chemical binding]; other site 272626006934 argininosuccinate lyase; Provisional; Region: PRK00855 272626006935 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272626006936 active sites [active] 272626006937 tetramer interface [polypeptide binding]; other site 272626006938 BCCT family transporter; Region: BCCT; pfam02028 272626006939 hypothetical protein; Provisional; Region: PRK06357 272626006940 active site 272626006941 intersubunit interface [polypeptide binding]; other site 272626006942 Zn2+ binding site [ion binding]; other site 272626006943 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272626006944 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272626006945 putative substrate binding site [chemical binding]; other site 272626006946 putative ATP binding site [chemical binding]; other site 272626006947 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 272626006948 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272626006949 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 272626006950 active site 272626006951 P-loop; other site 272626006952 phosphorylation site [posttranslational modification] 272626006953 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626006954 active site 272626006955 phosphorylation site [posttranslational modification] 272626006956 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626006957 PRD domain; Region: PRD; pfam00874 272626006958 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626006959 active site 272626006960 P-loop; other site 272626006961 phosphorylation site [posttranslational modification] 272626006962 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 272626006963 active site 272626006964 phosphorylation site [posttranslational modification] 272626006965 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272626006966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626006967 DNA-binding site [nucleotide binding]; DNA binding site 272626006968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626006969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626006970 homodimer interface [polypeptide binding]; other site 272626006971 catalytic residue [active] 272626006972 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 272626006973 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 272626006974 active site 272626006975 multimer interface [polypeptide binding]; other site 272626006976 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 272626006977 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 272626006978 predicted active site [active] 272626006979 catalytic triad [active] 272626006980 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272626006981 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 272626006982 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 272626006983 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272626006984 G1 box; other site 272626006985 GTP/Mg2+ binding site [chemical binding]; other site 272626006986 Switch I region; other site 272626006987 G2 box; other site 272626006988 G3 box; other site 272626006989 Switch II region; other site 272626006990 G4 box; other site 272626006991 G5 box; other site 272626006992 Nucleoside recognition; Region: Gate; pfam07670 272626006993 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272626006994 Nucleoside recognition; Region: Gate; pfam07670 272626006995 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272626006996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272626006997 putative active site [active] 272626006998 putative metal binding site [ion binding]; other site 272626006999 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626007000 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272626007001 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626007002 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272626007003 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272626007004 active site 272626007005 dimer interface [polypeptide binding]; other site 272626007006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272626007007 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272626007008 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 272626007009 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272626007010 dimer interface [polypeptide binding]; other site 272626007011 FMN binding site [chemical binding]; other site 272626007012 NADPH bind site [chemical binding]; other site 272626007013 Helix-turn-helix domain; Region: HTH_17; pfam12728 272626007014 putative heme peroxidase; Provisional; Region: PRK12276 272626007015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626007016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626007017 Walker A/P-loop; other site 272626007018 ATP binding site [chemical binding]; other site 272626007019 Q-loop/lid; other site 272626007020 ABC transporter signature motif; other site 272626007021 Walker B; other site 272626007022 D-loop; other site 272626007023 H-loop/switch region; other site 272626007024 FtsX-like permease family; Region: FtsX; pfam02687 272626007025 FtsX-like permease family; Region: FtsX; pfam02687 272626007026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626007027 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272626007028 Coenzyme A binding pocket [chemical binding]; other site 272626007029 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272626007030 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272626007031 active site 272626007032 substrate binding site [chemical binding]; other site 272626007033 metal binding site [ion binding]; metal-binding site 272626007034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 272626007035 YbbR-like protein; Region: YbbR; pfam07949 272626007036 YbbR-like protein; Region: YbbR; pfam07949 272626007037 YbbR-like protein; Region: YbbR; pfam07949 272626007038 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272626007039 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272626007040 maltose phosphorylase; Provisional; Region: PRK13807 272626007041 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272626007042 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272626007043 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272626007044 Predicted integral membrane protein [Function unknown]; Region: COG5521 272626007045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626007046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007047 dimer interface [polypeptide binding]; other site 272626007048 conserved gate region; other site 272626007049 putative PBP binding loops; other site 272626007050 ABC-ATPase subunit interface; other site 272626007051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007052 dimer interface [polypeptide binding]; other site 272626007053 conserved gate region; other site 272626007054 putative PBP binding loops; other site 272626007055 ABC-ATPase subunit interface; other site 272626007056 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272626007057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626007058 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272626007059 homodimer interface [polypeptide binding]; other site 272626007060 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272626007061 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272626007062 active site 272626007063 homodimer interface [polypeptide binding]; other site 272626007064 catalytic site [active] 272626007065 CAAX protease self-immunity; Region: Abi; pfam02517 272626007066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626007067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626007068 DNA binding site [nucleotide binding] 272626007069 domain linker motif; other site 272626007070 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272626007071 ligand binding site [chemical binding]; other site 272626007072 dimerization interface [polypeptide binding]; other site 272626007073 Amino acid permease; Region: AA_permease_2; pfam13520 272626007074 K+ potassium transporter; Region: K_trans; cl15781 272626007075 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626007076 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626007077 ligand binding site [chemical binding]; other site 272626007078 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626007079 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272626007080 ligand binding site [chemical binding]; other site 272626007081 flexible hinge region; other site 272626007082 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272626007083 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272626007084 intersubunit interface [polypeptide binding]; other site 272626007085 active site 272626007086 zinc binding site [ion binding]; other site 272626007087 Na+ binding site [ion binding]; other site 272626007088 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272626007089 intersubunit interface [polypeptide binding]; other site 272626007090 active site 272626007091 zinc binding site [ion binding]; other site 272626007092 Na+ binding site [ion binding]; other site 272626007093 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272626007094 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272626007095 active site 272626007096 P-loop; other site 272626007097 phosphorylation site [posttranslational modification] 272626007098 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626007099 active site 272626007100 phosphorylation site [posttranslational modification] 272626007101 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626007102 HTH domain; Region: HTH_11; pfam08279 272626007103 PRD domain; Region: PRD; pfam00874 272626007104 PRD domain; Region: PRD; pfam00874 272626007105 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626007106 active site 272626007107 P-loop; other site 272626007108 phosphorylation site [posttranslational modification] 272626007109 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272626007110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626007111 Walker A/P-loop; other site 272626007112 ATP binding site [chemical binding]; other site 272626007113 Q-loop/lid; other site 272626007114 ABC transporter signature motif; other site 272626007115 Walker B; other site 272626007116 D-loop; other site 272626007117 H-loop/switch region; other site 272626007118 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272626007119 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272626007120 putative acetyltransferase; Provisional; Region: PRK03624 272626007121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626007122 Coenzyme A binding pocket [chemical binding]; other site 272626007123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272626007124 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272626007125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272626007126 DNA-binding site [nucleotide binding]; DNA binding site 272626007127 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 272626007128 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 272626007129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626007130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626007131 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272626007132 putative dimerization interface [polypeptide binding]; other site 272626007133 Predicted membrane protein [Function unknown]; Region: COG2855 272626007134 Predicted membrane protein [Function unknown]; Region: COG4330 272626007135 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 272626007136 putative metal binding site [ion binding]; other site 272626007137 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 272626007138 homodimer interface [polypeptide binding]; other site 272626007139 chemical substrate binding site [chemical binding]; other site 272626007140 oligomer interface [polypeptide binding]; other site 272626007141 metal binding site [ion binding]; metal-binding site 272626007142 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626007143 catalytic residues [active] 272626007144 flavodoxin; Provisional; Region: PRK09271 272626007145 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272626007146 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272626007147 dimer interface [polypeptide binding]; other site 272626007148 putative radical transfer pathway; other site 272626007149 diiron center [ion binding]; other site 272626007150 tyrosyl radical; other site 272626007151 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 272626007152 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272626007153 active site 272626007154 dimer interface [polypeptide binding]; other site 272626007155 catalytic residues [active] 272626007156 effector binding site; other site 272626007157 R2 peptide binding site; other site 272626007158 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 272626007159 CsbD-like; Region: CsbD; cl17424 272626007160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626007161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626007162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272626007163 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272626007164 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 272626007165 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 272626007166 conserved cys residue [active] 272626007167 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272626007168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626007169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626007170 Cupin domain; Region: Cupin_2; pfam07883 272626007171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626007172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626007173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626007174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626007175 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272626007176 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626007177 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626007178 ligand binding site [chemical binding]; other site 272626007179 flexible hinge region; other site 272626007180 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272626007181 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272626007182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626007183 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272626007184 dimer interface [polypeptide binding]; other site 272626007185 active site 272626007186 metal binding site [ion binding]; metal-binding site 272626007187 glutathione binding site [chemical binding]; other site 272626007188 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 272626007189 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272626007190 FMN binding site [chemical binding]; other site 272626007191 substrate binding site [chemical binding]; other site 272626007192 putative catalytic residue [active] 272626007193 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 272626007194 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 272626007195 Coenzyme A transferase; Region: CoA_trans; smart00882 272626007196 Coenzyme A transferase; Region: CoA_trans; cl17247 272626007197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626007198 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 272626007199 Walker A motif; other site 272626007200 ATP binding site [chemical binding]; other site 272626007201 Walker B motif; other site 272626007202 arginine finger; other site 272626007203 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272626007204 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272626007205 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272626007206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272626007207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272626007208 metal binding site [ion binding]; metal-binding site 272626007209 active site 272626007210 I-site; other site 272626007211 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272626007212 classical (c) SDRs; Region: SDR_c; cd05233 272626007213 NAD(P) binding site [chemical binding]; other site 272626007214 active site 272626007215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626007216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626007217 Tic20-like protein; Region: Tic20; pfam09685 272626007218 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272626007219 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007220 Collagen binding domain; Region: Collagen_bind; pfam05737 272626007221 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007222 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007223 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007224 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007225 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007226 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007227 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 272626007228 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007229 Collagen binding domain; Region: Collagen_bind; pfam05737 272626007230 Collagen binding domain; Region: Collagen_bind; pfam05737 272626007231 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007232 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007233 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007234 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007235 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007236 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007237 Cna protein B-type domain; Region: Cna_B; pfam05738 272626007238 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007239 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007240 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007241 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272626007242 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 272626007243 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 272626007244 active site 272626007245 catalytic site [active] 272626007246 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272626007247 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272626007248 Walker A/P-loop; other site 272626007249 ATP binding site [chemical binding]; other site 272626007250 Q-loop/lid; other site 272626007251 ABC transporter signature motif; other site 272626007252 Walker B; other site 272626007253 D-loop; other site 272626007254 H-loop/switch region; other site 272626007255 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272626007256 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626007257 ABC-ATPase subunit interface; other site 272626007258 dimer interface [polypeptide binding]; other site 272626007259 putative PBP binding regions; other site 272626007260 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 272626007261 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272626007262 intersubunit interface [polypeptide binding]; other site 272626007263 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272626007264 heme-binding site [chemical binding]; other site 272626007265 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 272626007266 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272626007267 heme-binding site [chemical binding]; other site 272626007268 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272626007269 heme-binding site [chemical binding]; other site 272626007270 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 272626007271 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 272626007272 heme-binding site [chemical binding]; other site 272626007273 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 272626007274 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 272626007275 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272626007276 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272626007277 active site 272626007278 Zn binding site [ion binding]; other site 272626007279 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 272626007280 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 272626007281 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272626007282 ArsC family; Region: ArsC; pfam03960 272626007283 putative catalytic residues [active] 272626007284 thiol/disulfide switch; other site 272626007285 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272626007286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272626007287 Walker A/P-loop; other site 272626007288 ATP binding site [chemical binding]; other site 272626007289 Q-loop/lid; other site 272626007290 ABC transporter signature motif; other site 272626007291 Walker B; other site 272626007292 D-loop; other site 272626007293 H-loop/switch region; other site 272626007294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272626007295 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272626007296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272626007297 Walker A/P-loop; other site 272626007298 ATP binding site [chemical binding]; other site 272626007299 Q-loop/lid; other site 272626007300 ABC transporter signature motif; other site 272626007301 Walker B; other site 272626007302 D-loop; other site 272626007303 H-loop/switch region; other site 272626007304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272626007305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272626007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007307 dimer interface [polypeptide binding]; other site 272626007308 conserved gate region; other site 272626007309 putative PBP binding loops; other site 272626007310 ABC-ATPase subunit interface; other site 272626007311 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272626007312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007313 dimer interface [polypeptide binding]; other site 272626007314 conserved gate region; other site 272626007315 putative PBP binding loops; other site 272626007316 ABC-ATPase subunit interface; other site 272626007317 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272626007318 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272626007319 peptide binding site [polypeptide binding]; other site 272626007320 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272626007321 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272626007322 active site 272626007323 HIGH motif; other site 272626007324 dimer interface [polypeptide binding]; other site 272626007325 KMSKS motif; other site 272626007326 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 272626007327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626007328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626007329 putative DNA binding site [nucleotide binding]; other site 272626007330 putative Zn2+ binding site [ion binding]; other site 272626007331 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272626007332 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272626007333 dimer interface [polypeptide binding]; other site 272626007334 active site 272626007335 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272626007336 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272626007337 dimer interface [polypeptide binding]; other site 272626007338 active site 272626007339 CoA binding pocket [chemical binding]; other site 272626007340 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626007341 SH3-like domain; Region: SH3_8; pfam13457 272626007342 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 272626007343 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626007344 catalytic core [active] 272626007345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272626007346 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272626007347 Clp amino terminal domain; Region: Clp_N; pfam02861 272626007348 Clp amino terminal domain; Region: Clp_N; pfam02861 272626007349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626007350 Walker A motif; other site 272626007351 ATP binding site [chemical binding]; other site 272626007352 Walker B motif; other site 272626007353 arginine finger; other site 272626007354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626007355 Walker A motif; other site 272626007356 ATP binding site [chemical binding]; other site 272626007357 Walker B motif; other site 272626007358 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272626007359 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272626007360 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272626007361 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626007362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007363 active site 272626007364 motif I; other site 272626007365 motif II; other site 272626007366 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272626007367 Predicted acetyltransferase [General function prediction only]; Region: COG3393 272626007368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272626007369 ferrochelatase; Provisional; Region: PRK12435 272626007370 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272626007371 C-terminal domain interface [polypeptide binding]; other site 272626007372 active site 272626007373 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272626007374 active site 272626007375 N-terminal domain interface [polypeptide binding]; other site 272626007376 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 272626007377 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272626007378 substrate binding site [chemical binding]; other site 272626007379 active site 272626007380 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272626007381 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 272626007382 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272626007383 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626007384 Walker A/P-loop; other site 272626007385 ATP binding site [chemical binding]; other site 272626007386 Q-loop/lid; other site 272626007387 ABC transporter signature motif; other site 272626007388 Walker B; other site 272626007389 D-loop; other site 272626007390 H-loop/switch region; other site 272626007391 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272626007392 HIT family signature motif; other site 272626007393 catalytic residue [active] 272626007394 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 272626007395 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 272626007396 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 272626007397 SurA N-terminal domain; Region: SurA_N_3; cl07813 272626007398 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272626007399 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 272626007400 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272626007401 generic binding surface II; other site 272626007402 generic binding surface I; other site 272626007403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626007404 Zn2+ binding site [ion binding]; other site 272626007405 Mg2+ binding site [ion binding]; other site 272626007406 Uncharacterized conserved protein [Function unknown]; Region: COG4717 272626007407 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272626007408 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272626007409 active site 272626007410 metal binding site [ion binding]; metal-binding site 272626007411 DNA binding site [nucleotide binding] 272626007412 hypothetical protein; Provisional; Region: PRK13676 272626007413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 272626007414 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272626007415 Class II fumarases; Region: Fumarase_classII; cd01362 272626007416 active site 272626007417 tetramer interface [polypeptide binding]; other site 272626007418 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626007419 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626007420 Walker A/P-loop; other site 272626007421 ATP binding site [chemical binding]; other site 272626007422 Q-loop/lid; other site 272626007423 ABC transporter signature motif; other site 272626007424 Walker B; other site 272626007425 D-loop; other site 272626007426 H-loop/switch region; other site 272626007427 Transglycosylase; Region: Transgly; pfam00912 272626007428 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272626007429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272626007430 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272626007431 Low molecular weight phosphatase family; Region: LMWPc; cl00105 272626007432 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272626007433 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272626007434 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272626007435 Domain of unknown function DUF21; Region: DUF21; pfam01595 272626007436 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272626007437 Transporter associated domain; Region: CorC_HlyC; smart01091 272626007438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626007439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626007440 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272626007441 putative dimerization interface [polypeptide binding]; other site 272626007442 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272626007443 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272626007444 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272626007445 active site 272626007446 FMN binding site [chemical binding]; other site 272626007447 substrate binding site [chemical binding]; other site 272626007448 putative catalytic residue [active] 272626007449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272626007450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626007451 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 272626007452 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272626007453 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272626007454 shikimate binding site; other site 272626007455 NAD(P) binding site [chemical binding]; other site 272626007456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626007457 putative substrate translocation pore; other site 272626007458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626007460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626007461 putative substrate translocation pore; other site 272626007462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626007463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626007464 Walker A/P-loop; other site 272626007465 ATP binding site [chemical binding]; other site 272626007466 Q-loop/lid; other site 272626007467 ABC transporter signature motif; other site 272626007468 Walker B; other site 272626007469 D-loop; other site 272626007470 H-loop/switch region; other site 272626007471 Predicted transcriptional regulators [Transcription]; Region: COG1725 272626007472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272626007473 DNA-binding site [nucleotide binding]; DNA binding site 272626007474 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 272626007475 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272626007476 DNA binding site [nucleotide binding] 272626007477 active site 272626007478 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272626007479 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272626007480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626007481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626007482 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272626007483 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272626007484 active site 272626007485 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 272626007486 putative dimer interface [polypeptide binding]; other site 272626007487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272626007488 ligand binding site [chemical binding]; other site 272626007489 Zn binding site [ion binding]; other site 272626007490 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 272626007491 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 272626007492 active site 272626007493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626007494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626007495 active site 272626007496 catalytic tetrad [active] 272626007497 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 272626007498 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272626007499 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272626007500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272626007501 substrate binding pocket [chemical binding]; other site 272626007502 membrane-bound complex binding site; other site 272626007503 hinge residues; other site 272626007504 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272626007505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007506 dimer interface [polypeptide binding]; other site 272626007507 conserved gate region; other site 272626007508 putative PBP binding loops; other site 272626007509 ABC-ATPase subunit interface; other site 272626007510 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272626007511 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272626007512 Walker A/P-loop; other site 272626007513 ATP binding site [chemical binding]; other site 272626007514 Q-loop/lid; other site 272626007515 ABC transporter signature motif; other site 272626007516 Walker B; other site 272626007517 D-loop; other site 272626007518 H-loop/switch region; other site 272626007519 aspartate aminotransferase; Provisional; Region: PRK06348 272626007520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626007521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626007522 homodimer interface [polypeptide binding]; other site 272626007523 catalytic residue [active] 272626007524 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272626007525 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272626007526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007527 motif II; other site 272626007528 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272626007529 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272626007530 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272626007531 proposed catalytic triad [active] 272626007532 conserved cys residue [active] 272626007533 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 272626007534 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626007535 methionine cluster; other site 272626007536 active site 272626007537 phosphorylation site [posttranslational modification] 272626007538 metal binding site [ion binding]; metal-binding site 272626007539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626007540 Coenzyme A binding pocket [chemical binding]; other site 272626007541 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272626007542 esterase; Provisional; Region: PRK10566 272626007543 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272626007544 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626007545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272626007546 motif II; other site 272626007547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007548 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272626007549 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626007550 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626007551 hypothetical protein; Provisional; Region: PRK13673 272626007552 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 272626007553 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272626007554 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272626007555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272626007556 Family description; Region: UvrD_C_2; pfam13538 272626007557 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272626007558 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 272626007559 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272626007560 IDEAL domain; Region: IDEAL; pfam08858 272626007561 ComK protein; Region: ComK; cl11560 272626007562 Abortive infection bacteriophage resistance protein [Defense mechanisms]; Region: AbiF; COG4823 272626007563 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 272626007564 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272626007565 amidase catalytic site [active] 272626007566 Zn binding residues [ion binding]; other site 272626007567 substrate binding site [chemical binding]; other site 272626007568 holin, phage phi LC3 family; Region: holin_phiLC3; TIGR01598 272626007569 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 272626007570 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272626007571 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 272626007572 Phage tail protein; Region: Sipho_tail; pfam05709 272626007573 Phage-related tail protein [Function unknown]; Region: COG5283 272626007574 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 272626007575 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 272626007576 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 272626007577 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 272626007578 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 272626007579 Terminase-like family; Region: Terminase_6; pfam03237 272626007580 Uncharacterized conserved protein [Function unknown]; Region: COG5484 272626007581 Phage terminase small subunit; Region: Phage_terminase; pfam10668 272626007582 positive control sigma-like factor; Validated; Region: PRK06930 272626007583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272626007584 DNA binding residues [nucleotide binding] 272626007585 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 272626007586 Protein of unknown function (DUF2481); Region: DUF2481; pfam10654 272626007587 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 272626007588 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272626007589 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272626007590 dimer interface [polypeptide binding]; other site 272626007591 ssDNA binding site [nucleotide binding]; other site 272626007592 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626007594 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272626007595 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626007596 Int/Topo IB signature motif; other site 272626007597 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272626007598 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 272626007599 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 272626007600 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 272626007601 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 272626007602 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 272626007603 Prophage antirepressor [Transcription]; Region: COG3617 272626007604 BRO family, N-terminal domain; Region: Bro-N; smart01040 272626007605 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 272626007606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626007607 non-specific DNA binding site [nucleotide binding]; other site 272626007608 salt bridge; other site 272626007609 sequence-specific DNA binding site [nucleotide binding]; other site 272626007610 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626007611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626007612 non-specific DNA binding site [nucleotide binding]; other site 272626007613 salt bridge; other site 272626007614 sequence-specific DNA binding site [nucleotide binding]; other site 272626007615 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 272626007616 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272626007617 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272626007618 catalytic residues [active] 272626007619 catalytic nucleophile [active] 272626007620 Presynaptic Site I dimer interface [polypeptide binding]; other site 272626007621 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272626007622 Synaptic Flat tetramer interface [polypeptide binding]; other site 272626007623 Synaptic Site I dimer interface [polypeptide binding]; other site 272626007624 DNA binding site [nucleotide binding] 272626007625 Recombinase; Region: Recombinase; pfam07508 272626007626 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272626007627 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 272626007628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626007629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626007630 non-specific DNA binding site [nucleotide binding]; other site 272626007631 salt bridge; other site 272626007632 sequence-specific DNA binding site [nucleotide binding]; other site 272626007633 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272626007634 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626007635 active site 272626007636 phosphorylation site [posttranslational modification] 272626007637 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272626007638 active site 272626007639 P-loop; other site 272626007640 phosphorylation site [posttranslational modification] 272626007641 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272626007642 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272626007643 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272626007644 putative substrate binding site [chemical binding]; other site 272626007645 putative ATP binding site [chemical binding]; other site 272626007646 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626007647 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272626007648 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626007649 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272626007650 trimer interface [polypeptide binding]; other site 272626007651 active site 272626007652 G bulge; other site 272626007653 Uncharacterized conserved protein [Function unknown]; Region: COG1683 272626007654 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 272626007655 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272626007656 non-specific DNA interactions [nucleotide binding]; other site 272626007657 DNA binding site [nucleotide binding] 272626007658 sequence specific DNA binding site [nucleotide binding]; other site 272626007659 putative cAMP binding site [chemical binding]; other site 272626007660 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 272626007661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272626007662 substrate binding site [chemical binding]; other site 272626007663 ATP binding site [chemical binding]; other site 272626007664 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272626007665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272626007666 RNA binding surface [nucleotide binding]; other site 272626007667 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272626007668 active site 272626007669 uracil binding [chemical binding]; other site 272626007670 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 272626007671 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272626007672 active site 272626007673 non-prolyl cis peptide bond; other site 272626007674 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272626007675 catalytic residues [active] 272626007676 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 272626007677 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272626007678 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272626007679 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272626007680 Walker A/P-loop; other site 272626007681 ATP binding site [chemical binding]; other site 272626007682 Q-loop/lid; other site 272626007683 ABC transporter signature motif; other site 272626007684 Walker B; other site 272626007685 D-loop; other site 272626007686 H-loop/switch region; other site 272626007687 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272626007688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007689 dimer interface [polypeptide binding]; other site 272626007690 conserved gate region; other site 272626007691 putative PBP binding loops; other site 272626007692 ABC-ATPase subunit interface; other site 272626007693 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272626007694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007695 dimer interface [polypeptide binding]; other site 272626007696 conserved gate region; other site 272626007697 putative PBP binding loops; other site 272626007698 ABC-ATPase subunit interface; other site 272626007699 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272626007700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272626007701 substrate binding pocket [chemical binding]; other site 272626007702 membrane-bound complex binding site; other site 272626007703 hinge residues; other site 272626007704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626007705 Coenzyme A binding pocket [chemical binding]; other site 272626007706 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272626007707 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272626007708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272626007709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272626007710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272626007711 dimerization interface [polypeptide binding]; other site 272626007712 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272626007713 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272626007714 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 272626007715 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272626007716 active site 272626007717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626007718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626007719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626007720 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272626007721 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272626007722 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272626007723 active site 272626007724 trimer interface [polypeptide binding]; other site 272626007725 allosteric site; other site 272626007726 active site lid [active] 272626007727 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272626007728 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626007729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007730 active site 272626007731 motif I; other site 272626007732 motif II; other site 272626007733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007734 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272626007735 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 272626007736 NAD binding site [chemical binding]; other site 272626007737 sugar binding site [chemical binding]; other site 272626007738 divalent metal binding site [ion binding]; other site 272626007739 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626007740 dimer interface [polypeptide binding]; other site 272626007741 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626007742 HTH domain; Region: HTH_11; pfam08279 272626007743 PRD domain; Region: PRD; pfam00874 272626007744 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626007745 active site 272626007746 phosphorylation site [posttranslational modification] 272626007747 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 272626007748 putative active site [active] 272626007749 YdjC motif; other site 272626007750 Mg binding site [ion binding]; other site 272626007751 putative homodimer interface [polypeptide binding]; other site 272626007752 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626007753 methionine cluster; other site 272626007754 active site 272626007755 phosphorylation site [posttranslational modification] 272626007756 metal binding site [ion binding]; metal-binding site 272626007757 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626007758 active site 272626007759 P-loop; other site 272626007760 phosphorylation site [posttranslational modification] 272626007761 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626007762 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626007763 Predicted membrane protein [Function unknown]; Region: COG1511 272626007764 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272626007765 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272626007766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626007767 Predicted transcriptional regulator [Transcription]; Region: COG1959 272626007768 Transcriptional regulator; Region: Rrf2; pfam02082 272626007769 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 272626007770 L-tyrosine decarboxylase; Provisional; Region: PRK13520 272626007771 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272626007772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626007773 catalytic residue [active] 272626007774 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 272626007775 Mga helix-turn-helix domain; Region: Mga; pfam05043 272626007776 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 272626007777 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272626007778 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272626007779 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272626007780 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272626007781 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272626007782 active site 272626007783 dimer interface [polypeptide binding]; other site 272626007784 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272626007785 dimer interface [polypeptide binding]; other site 272626007786 active site 272626007787 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272626007788 nudix motif; other site 272626007789 general stress protein 13; Validated; Region: PRK08059 272626007790 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 272626007791 RNA binding site [nucleotide binding]; other site 272626007792 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 272626007793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272626007794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626007795 homodimer interface [polypeptide binding]; other site 272626007796 catalytic residue [active] 272626007797 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272626007798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626007799 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626007800 Walker A/P-loop; other site 272626007801 ATP binding site [chemical binding]; other site 272626007802 Q-loop/lid; other site 272626007803 ABC transporter signature motif; other site 272626007804 Walker B; other site 272626007805 D-loop; other site 272626007806 H-loop/switch region; other site 272626007807 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626007808 active site 272626007809 P-loop; other site 272626007810 phosphorylation site [posttranslational modification] 272626007811 aspartate kinase; Reviewed; Region: PRK09034 272626007812 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272626007813 putative catalytic residues [active] 272626007814 putative nucleotide binding site [chemical binding]; other site 272626007815 putative aspartate binding site [chemical binding]; other site 272626007816 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272626007817 allosteric regulatory residue; other site 272626007818 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272626007819 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 272626007820 active site 272626007821 drug efflux system protein MdtG; Provisional; Region: PRK09874 272626007822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626007823 putative substrate translocation pore; other site 272626007824 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 272626007825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272626007826 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 272626007827 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 272626007828 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 272626007829 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 272626007830 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272626007831 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 272626007832 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 272626007833 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 272626007834 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272626007835 CoenzymeA binding site [chemical binding]; other site 272626007836 subunit interaction site [polypeptide binding]; other site 272626007837 PHB binding site; other site 272626007838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 272626007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 272626007840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 272626007841 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272626007842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626007843 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272626007844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626007845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626007846 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272626007847 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272626007848 NAD(P) binding site [chemical binding]; other site 272626007849 putative active site [active] 272626007850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 272626007851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 272626007852 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 272626007853 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007854 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007855 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007856 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007857 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007858 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007859 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 272626007860 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272626007861 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272626007862 tetramer interfaces [polypeptide binding]; other site 272626007863 binuclear metal-binding site [ion binding]; other site 272626007864 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272626007865 Domain of unknown function DUF21; Region: DUF21; pfam01595 272626007866 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272626007867 Transporter associated domain; Region: CorC_HlyC; smart01091 272626007868 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272626007869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626007870 Coenzyme A binding pocket [chemical binding]; other site 272626007871 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272626007872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007873 active site 272626007874 motif I; other site 272626007875 motif II; other site 272626007876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626007877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 272626007878 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272626007879 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272626007880 active site 272626007881 metal binding site [ion binding]; metal-binding site 272626007882 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272626007883 Predicted permeases [General function prediction only]; Region: COG0730 272626007884 Predicted membrane protein [Function unknown]; Region: COG4272 272626007885 Uncharacterized conserved protein [Function unknown]; Region: COG1801 272626007886 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 272626007887 FeS assembly protein SufB; Region: sufB; TIGR01980 272626007888 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272626007889 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272626007890 trimerization site [polypeptide binding]; other site 272626007891 active site 272626007892 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272626007893 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272626007894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626007895 catalytic residue [active] 272626007896 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272626007897 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 272626007898 FeS assembly protein SufD; Region: sufD; TIGR01981 272626007899 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 272626007900 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272626007901 Walker A/P-loop; other site 272626007902 ATP binding site [chemical binding]; other site 272626007903 Q-loop/lid; other site 272626007904 ABC transporter signature motif; other site 272626007905 Walker B; other site 272626007906 D-loop; other site 272626007907 H-loop/switch region; other site 272626007908 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272626007909 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272626007910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626007911 ABC-ATPase subunit interface; other site 272626007912 putative PBP binding loops; other site 272626007913 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272626007914 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272626007915 Walker A/P-loop; other site 272626007916 ATP binding site [chemical binding]; other site 272626007917 Q-loop/lid; other site 272626007918 ABC transporter signature motif; other site 272626007919 Walker B; other site 272626007920 D-loop; other site 272626007921 H-loop/switch region; other site 272626007922 NIL domain; Region: NIL; pfam09383 272626007923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272626007924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626007925 dimer interface [polypeptide binding]; other site 272626007926 phosphorylation site [posttranslational modification] 272626007927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626007928 ATP binding site [chemical binding]; other site 272626007929 Mg2+ binding site [ion binding]; other site 272626007930 G-X-G motif; other site 272626007931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626007932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626007933 active site 272626007934 phosphorylation site [posttranslational modification] 272626007935 intermolecular recognition site; other site 272626007936 dimerization interface [polypeptide binding]; other site 272626007937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626007938 DNA binding site [nucleotide binding] 272626007939 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272626007940 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272626007941 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626007942 catalytic residues [active] 272626007943 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272626007944 lipoyl attachment site [posttranslational modification]; other site 272626007945 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272626007946 ArsC family; Region: ArsC; pfam03960 272626007947 putative ArsC-like catalytic residues; other site 272626007948 putative TRX-like catalytic residues [active] 272626007949 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272626007950 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272626007951 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272626007952 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272626007953 Walker A/P-loop; other site 272626007954 ATP binding site [chemical binding]; other site 272626007955 Q-loop/lid; other site 272626007956 ABC transporter signature motif; other site 272626007957 Walker B; other site 272626007958 D-loop; other site 272626007959 H-loop/switch region; other site 272626007960 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272626007961 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272626007962 ABC-ATPase subunit interface; other site 272626007963 dimer interface [polypeptide binding]; other site 272626007964 putative PBP binding regions; other site 272626007965 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272626007966 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272626007967 intersubunit interface [polypeptide binding]; other site 272626007968 Predicted esterase [General function prediction only]; Region: COG0627 272626007969 S-formylglutathione hydrolase; Region: PLN02442 272626007970 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272626007971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626007972 catalytic residue [active] 272626007973 Predicted integral membrane protein [Function unknown]; Region: COG5658 272626007974 SdpI/YhfL protein family; Region: SdpI; pfam13630 272626007975 CAT RNA binding domain; Region: CAT_RBD; smart01061 272626007976 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272626007977 PRD domain; Region: PRD; pfam00874 272626007978 PRD domain; Region: PRD; pfam00874 272626007979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 272626007980 Uncharacterized conserved protein [Function unknown]; Region: COG4283 272626007981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 272626007982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 272626007983 Predicted transcriptional regulator [Transcription]; Region: COG2378 272626007984 HTH domain; Region: HTH_11; pfam08279 272626007985 WYL domain; Region: WYL; pfam13280 272626007986 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272626007987 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272626007988 putative active site [active] 272626007989 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626007990 Leucine rich repeat; Region: LRR_8; pfam13855 272626007991 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272626007992 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 272626007993 active site 272626007994 catalytic site [active] 272626007995 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 272626007996 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 272626007997 putative metal binding site [ion binding]; other site 272626007998 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 272626007999 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272626008000 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272626008001 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272626008002 active site 272626008003 catalytic site [active] 272626008004 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 272626008005 putative metal binding site [ion binding]; other site 272626008006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626008007 non-specific DNA binding site [nucleotide binding]; other site 272626008008 salt bridge; other site 272626008009 sequence-specific DNA binding site [nucleotide binding]; other site 272626008010 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272626008011 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272626008012 SmpB-tmRNA interface; other site 272626008013 ribonuclease R; Region: RNase_R; TIGR02063 272626008014 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272626008015 RNB domain; Region: RNB; pfam00773 272626008016 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272626008017 RNA binding site [nucleotide binding]; other site 272626008018 Esterase/lipase [General function prediction only]; Region: COG1647 272626008019 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626008020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272626008021 Preprotein translocase SecG subunit; Region: SecG; cl09123 272626008022 Esterase/lipase [General function prediction only]; Region: COG1647 272626008023 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272626008024 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272626008025 PGAP1-like protein; Region: PGAP1; pfam07819 272626008026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272626008027 enolase; Provisional; Region: eno; PRK00077 272626008028 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272626008029 dimer interface [polypeptide binding]; other site 272626008030 metal binding site [ion binding]; metal-binding site 272626008031 substrate binding pocket [chemical binding]; other site 272626008032 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272626008033 phosphoglyceromutase; Provisional; Region: PRK05434 272626008034 triosephosphate isomerase; Provisional; Region: PRK14567 272626008035 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272626008036 substrate binding site [chemical binding]; other site 272626008037 dimer interface [polypeptide binding]; other site 272626008038 catalytic triad [active] 272626008039 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272626008040 Phosphoglycerate kinase; Region: PGK; pfam00162 272626008041 substrate binding site [chemical binding]; other site 272626008042 hinge regions; other site 272626008043 ADP binding site [chemical binding]; other site 272626008044 catalytic site [active] 272626008045 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272626008046 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272626008047 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272626008048 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272626008049 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272626008050 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 272626008051 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272626008052 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272626008053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626008054 DNA binding site [nucleotide binding] 272626008055 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 272626008056 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 272626008057 active site 272626008058 dimer interface [polypeptide binding]; other site 272626008059 MMPL family; Region: MMPL; pfam03176 272626008060 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 272626008061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626008062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626008063 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 272626008064 Abortive infection bacteriophage resistance protein [Defense mechanisms]; Region: AbiF; COG4823 272626008065 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 272626008066 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272626008067 amidase catalytic site [active] 272626008068 Zn binding residues [ion binding]; other site 272626008069 substrate binding site [chemical binding]; other site 272626008070 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 272626008071 Phage-related protein [Function unknown]; Region: PblB; COG4926 272626008072 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 272626008073 Phage-related protein [Function unknown]; Region: COG4722 272626008074 Phage-related minor tail protein [Function unknown]; Region: COG5280 272626008075 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 272626008076 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 272626008077 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 272626008078 Phage capsid family; Region: Phage_capsid; pfam05065 272626008079 Phage head maturation protease [General function prediction only]; Region: COG3740 272626008080 Phage-related protein [Function unknown]; Region: COG4695; cl01923 272626008081 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 272626008082 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 272626008083 Phage terminase, small subunit; Region: Terminase_4; cl01525 272626008084 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272626008085 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 272626008086 putative active site [active] 272626008087 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 272626008088 Protein of unknown function (DUF722); Region: DUF722; pfam05263 272626008089 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 272626008090 VRR-NUC domain; Region: VRR_NUC; pfam08774 272626008091 Uncharacterized conserved protein [Function unknown]; Region: COG4983 272626008092 D5 N terminal like; Region: D5_N; pfam08706 272626008093 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 272626008094 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 272626008095 Protein of unknown function (DUF669); Region: DUF669; pfam05037 272626008096 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272626008097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626008098 ATP binding site [chemical binding]; other site 272626008099 putative Mg++ binding site [ion binding]; other site 272626008100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626008101 nucleotide binding region [chemical binding]; other site 272626008102 ATP-binding site [chemical binding]; other site 272626008103 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 272626008104 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 272626008105 AAA domain; Region: AAA_24; pfam13479 272626008106 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 272626008107 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 272626008108 Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921 272626008109 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272626008110 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626008111 Int/Topo IB signature motif; other site 272626008112 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272626008113 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272626008114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626008115 salt bridge; other site 272626008116 non-specific DNA binding site [nucleotide binding]; other site 272626008117 sequence-specific DNA binding site [nucleotide binding]; other site 272626008118 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 272626008119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626008120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626008121 non-specific DNA binding site [nucleotide binding]; other site 272626008122 salt bridge; other site 272626008123 sequence-specific DNA binding site [nucleotide binding]; other site 272626008124 Domain of unknown function (DUF955); Region: DUF955; pfam06114 272626008125 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272626008126 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272626008127 Int/Topo IB signature motif; other site 272626008128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 272626008129 Chitin binding domain; Region: Chitin_bind_3; pfam03067 272626008130 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 272626008131 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272626008132 Interdomain contacts; other site 272626008133 Cytokine receptor motif; other site 272626008134 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272626008135 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272626008136 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 272626008137 aromatic chitin/cellulose binding site residues [chemical binding]; other site 272626008138 Clp protease; Region: CLP_protease; pfam00574 272626008139 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272626008140 oligomer interface [polypeptide binding]; other site 272626008141 active site residues [active] 272626008142 amino acid transporter; Region: 2A0306; TIGR00909 272626008143 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272626008144 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272626008145 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272626008146 active site 272626008147 FMN binding site [chemical binding]; other site 272626008148 substrate binding site [chemical binding]; other site 272626008149 homotetramer interface [polypeptide binding]; other site 272626008150 catalytic residue [active] 272626008151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272626008152 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 272626008153 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 272626008154 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272626008155 phosphate binding site [ion binding]; other site 272626008156 putative substrate binding pocket [chemical binding]; other site 272626008157 dimer interface [polypeptide binding]; other site 272626008158 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 272626008159 AAA domain; Region: AAA_18; pfam13238 272626008160 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 272626008161 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272626008162 active site 272626008163 substrate binding site [chemical binding]; other site 272626008164 metal binding site [ion binding]; metal-binding site 272626008165 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272626008166 active site 272626008167 catalytic residues [active] 272626008168 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272626008169 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272626008170 NAD binding site [chemical binding]; other site 272626008171 homodimer interface [polypeptide binding]; other site 272626008172 active site 272626008173 substrate binding site [chemical binding]; other site 272626008174 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272626008175 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626008176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626008177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626008178 binding surface 272626008179 TPR motif; other site 272626008180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272626008181 binding surface 272626008182 TPR motif; other site 272626008183 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272626008184 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 272626008185 trimer interface [polypeptide binding]; other site 272626008186 active site 272626008187 substrate binding site [chemical binding]; other site 272626008188 CoA binding site [chemical binding]; other site 272626008189 pyrophosphatase PpaX; Provisional; Region: PRK13288 272626008190 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272626008191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626008192 motif II; other site 272626008193 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 272626008194 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272626008195 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272626008196 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272626008197 Hpr binding site; other site 272626008198 active site 272626008199 homohexamer subunit interaction site [polypeptide binding]; other site 272626008200 Predicted membrane protein [Function unknown]; Region: COG1950 272626008201 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272626008202 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 272626008203 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272626008204 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272626008205 Uncharacterized conserved protein [Function unknown]; Region: COG3595 272626008206 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272626008207 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272626008208 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272626008209 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272626008210 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272626008211 excinuclease ABC subunit B; Provisional; Region: PRK05298 272626008212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626008213 ATP binding site [chemical binding]; other site 272626008214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626008215 nucleotide binding region [chemical binding]; other site 272626008216 ATP-binding site [chemical binding]; other site 272626008217 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272626008218 UvrB/uvrC motif; Region: UVR; pfam02151 272626008219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 272626008220 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 272626008221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626008222 dimerization interface [polypeptide binding]; other site 272626008223 putative DNA binding site [nucleotide binding]; other site 272626008224 putative Zn2+ binding site [ion binding]; other site 272626008225 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272626008226 PhoU domain; Region: PhoU; pfam01895 272626008227 PhoU domain; Region: PhoU; pfam01895 272626008228 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272626008229 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272626008230 Walker A/P-loop; other site 272626008231 ATP binding site [chemical binding]; other site 272626008232 Q-loop/lid; other site 272626008233 ABC transporter signature motif; other site 272626008234 Walker B; other site 272626008235 D-loop; other site 272626008236 H-loop/switch region; other site 272626008237 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272626008238 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272626008239 Walker A/P-loop; other site 272626008240 ATP binding site [chemical binding]; other site 272626008241 Q-loop/lid; other site 272626008242 ABC transporter signature motif; other site 272626008243 Walker B; other site 272626008244 D-loop; other site 272626008245 H-loop/switch region; other site 272626008246 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272626008247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626008248 dimer interface [polypeptide binding]; other site 272626008249 conserved gate region; other site 272626008250 putative PBP binding loops; other site 272626008251 ABC-ATPase subunit interface; other site 272626008252 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272626008253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626008254 dimer interface [polypeptide binding]; other site 272626008255 conserved gate region; other site 272626008256 putative PBP binding loops; other site 272626008257 ABC-ATPase subunit interface; other site 272626008258 PBP superfamily domain; Region: PBP_like_2; cl17296 272626008259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272626008260 HAMP domain; Region: HAMP; pfam00672 272626008261 dimerization interface [polypeptide binding]; other site 272626008262 PAS domain; Region: PAS; smart00091 272626008263 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272626008264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626008265 dimer interface [polypeptide binding]; other site 272626008266 phosphorylation site [posttranslational modification] 272626008267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626008268 ATP binding site [chemical binding]; other site 272626008269 Mg2+ binding site [ion binding]; other site 272626008270 G-X-G motif; other site 272626008271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626008272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626008273 active site 272626008274 phosphorylation site [posttranslational modification] 272626008275 intermolecular recognition site; other site 272626008276 dimerization interface [polypeptide binding]; other site 272626008277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626008278 DNA binding site [nucleotide binding] 272626008279 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272626008280 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272626008281 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272626008282 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272626008283 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272626008284 putative active site [active] 272626008285 catalytic site [active] 272626008286 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272626008287 putative active site [active] 272626008288 catalytic site [active] 272626008289 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272626008290 Peptidase family M23; Region: Peptidase_M23; pfam01551 272626008291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272626008292 NlpC/P60 family; Region: NLPC_P60; pfam00877 272626008293 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 272626008294 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272626008295 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272626008296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626008297 Walker A/P-loop; other site 272626008298 ATP binding site [chemical binding]; other site 272626008299 Q-loop/lid; other site 272626008300 ABC transporter signature motif; other site 272626008301 Walker B; other site 272626008302 D-loop; other site 272626008303 H-loop/switch region; other site 272626008304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272626008305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626008306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272626008307 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272626008308 peptide chain release factor 2; Provisional; Region: PRK06746 272626008309 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272626008310 RF-1 domain; Region: RF-1; pfam00472 272626008311 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272626008312 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272626008313 nucleotide binding region [chemical binding]; other site 272626008314 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272626008315 ATP-binding site [chemical binding]; other site 272626008316 SEC-C motif; Region: SEC-C; pfam02810 272626008317 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272626008318 30S subunit binding site; other site 272626008319 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272626008320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626008321 active site 272626008322 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272626008323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626008324 ATP binding site [chemical binding]; other site 272626008325 putative Mg++ binding site [ion binding]; other site 272626008326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626008327 nucleotide binding region [chemical binding]; other site 272626008328 ATP-binding site [chemical binding]; other site 272626008329 EDD domain protein, DegV family; Region: DegV; TIGR00762 272626008330 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272626008331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272626008332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626008333 active site 272626008334 phosphorylation site [posttranslational modification] 272626008335 intermolecular recognition site; other site 272626008336 dimerization interface [polypeptide binding]; other site 272626008337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272626008338 DNA binding residues [nucleotide binding] 272626008339 dimerization interface [polypeptide binding]; other site 272626008340 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272626008341 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272626008342 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272626008343 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272626008344 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272626008345 Transcriptional regulator [Transcription]; Region: LytR; COG1316 272626008346 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272626008347 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272626008348 Mg++ binding site [ion binding]; other site 272626008349 putative catalytic motif [active] 272626008350 substrate binding site [chemical binding]; other site 272626008351 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 272626008352 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 272626008353 active site 272626008354 octamer interface [polypeptide binding]; other site 272626008355 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 272626008356 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272626008357 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008358 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272626008359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 272626008361 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272626008362 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272626008363 dimer interface [polypeptide binding]; other site 272626008364 ssDNA binding site [nucleotide binding]; other site 272626008365 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272626008366 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272626008367 rod shape-determining protein Mbl; Provisional; Region: PRK13928 272626008368 MreB and similar proteins; Region: MreB_like; cd10225 272626008369 nucleotide binding site [chemical binding]; other site 272626008370 Mg binding site [ion binding]; other site 272626008371 putative protofilament interaction site [polypeptide binding]; other site 272626008372 RodZ interaction site [polypeptide binding]; other site 272626008373 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272626008374 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272626008375 hinge; other site 272626008376 active site 272626008377 Predicted membrane protein [Function unknown]; Region: COG4836 272626008378 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272626008379 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272626008380 gamma subunit interface [polypeptide binding]; other site 272626008381 epsilon subunit interface [polypeptide binding]; other site 272626008382 LBP interface [polypeptide binding]; other site 272626008383 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272626008384 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272626008385 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272626008386 alpha subunit interaction interface [polypeptide binding]; other site 272626008387 Walker A motif; other site 272626008388 ATP binding site [chemical binding]; other site 272626008389 Walker B motif; other site 272626008390 inhibitor binding site; inhibition site 272626008391 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272626008392 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272626008393 core domain interface [polypeptide binding]; other site 272626008394 delta subunit interface [polypeptide binding]; other site 272626008395 epsilon subunit interface [polypeptide binding]; other site 272626008396 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272626008397 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272626008398 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272626008399 beta subunit interaction interface [polypeptide binding]; other site 272626008400 Walker A motif; other site 272626008401 ATP binding site [chemical binding]; other site 272626008402 Walker B motif; other site 272626008403 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272626008404 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272626008405 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272626008406 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272626008407 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272626008408 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 272626008409 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272626008410 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272626008411 ATP synthase I chain; Region: ATP_synt_I; pfam03899 272626008412 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272626008413 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272626008414 active site 272626008415 homodimer interface [polypeptide binding]; other site 272626008416 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626008417 active site 272626008418 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272626008419 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272626008420 dimer interface [polypeptide binding]; other site 272626008421 active site 272626008422 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272626008423 folate binding site [chemical binding]; other site 272626008424 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272626008425 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272626008426 active site 272626008427 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272626008428 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272626008429 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272626008430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626008431 S-adenosylmethionine binding site [chemical binding]; other site 272626008432 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272626008433 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272626008434 RF-1 domain; Region: RF-1; pfam00472 272626008435 thymidine kinase; Provisional; Region: PRK04296 272626008436 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272626008437 ATP binding site [chemical binding]; other site 272626008438 Walker A motif; other site 272626008439 Walker B motif; other site 272626008440 homoserine kinase; Provisional; Region: PRK01212 272626008441 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272626008442 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272626008443 threonine synthase; Reviewed; Region: PRK06721 272626008444 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 272626008445 homodimer interface [polypeptide binding]; other site 272626008446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626008447 catalytic residue [active] 272626008448 homoserine dehydrogenase; Provisional; Region: PRK06349 272626008449 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272626008450 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272626008451 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 272626008452 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272626008453 Predicted membrane protein [Function unknown]; Region: COG2246 272626008454 GtrA-like protein; Region: GtrA; pfam04138 272626008455 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272626008456 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272626008457 Ligand binding site; other site 272626008458 Putative Catalytic site; other site 272626008459 DXD motif; other site 272626008460 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272626008461 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272626008462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272626008463 RNA binding site [nucleotide binding]; other site 272626008464 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272626008465 multimer interface [polypeptide binding]; other site 272626008466 Walker A motif; other site 272626008467 ATP binding site [chemical binding]; other site 272626008468 Walker B motif; other site 272626008469 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272626008470 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272626008471 hinge; other site 272626008472 active site 272626008473 Predicted integral membrane protein [Function unknown]; Region: COG0392 272626008474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272626008475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272626008476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272626008477 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272626008478 putative ADP-binding pocket [chemical binding]; other site 272626008479 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272626008480 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272626008481 intersubunit interface [polypeptide binding]; other site 272626008482 active site 272626008483 zinc binding site [ion binding]; other site 272626008484 Na+ binding site [ion binding]; other site 272626008485 putative lipid kinase; Reviewed; Region: PRK13055 272626008486 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272626008487 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 272626008488 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272626008489 amidase catalytic site [active] 272626008490 Zn binding residues [ion binding]; other site 272626008491 substrate binding site [chemical binding]; other site 272626008492 SH3-like domain; Region: SH3_8; pfam13457 272626008493 SH3-like domain; Region: SH3_8; pfam13457 272626008494 SH3-like domain; Region: SH3_8; pfam13457 272626008495 CTP synthetase; Validated; Region: pyrG; PRK05380 272626008496 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272626008497 Catalytic site [active] 272626008498 active site 272626008499 UTP binding site [chemical binding]; other site 272626008500 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272626008501 active site 272626008502 putative oxyanion hole; other site 272626008503 catalytic triad [active] 272626008504 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 272626008505 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272626008506 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272626008507 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272626008508 active site 272626008509 HIGH motif; other site 272626008510 KMSK motif region; other site 272626008511 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272626008512 tRNA binding surface [nucleotide binding]; other site 272626008513 anticodon binding site; other site 272626008514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 272626008515 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 272626008516 Peptidase family M50; Region: Peptidase_M50; pfam02163 272626008517 active site 272626008518 putative substrate binding region [chemical binding]; other site 272626008519 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 272626008520 active site 1 [active] 272626008521 dimer interface [polypeptide binding]; other site 272626008522 hexamer interface [polypeptide binding]; other site 272626008523 active site 2 [active] 272626008524 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272626008525 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626008526 Zn2+ binding site [ion binding]; other site 272626008527 Mg2+ binding site [ion binding]; other site 272626008528 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272626008529 conserved hypothetical protein TIGR01655; Region: yxeA_fam 272626008530 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272626008531 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272626008532 peptide binding site [polypeptide binding]; other site 272626008533 Predicted integral membrane protein [Function unknown]; Region: COG5658 272626008534 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 272626008535 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272626008536 catalytic triad [active] 272626008537 metal binding site [ion binding]; metal-binding site 272626008538 conserved cis-peptide bond; other site 272626008539 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272626008540 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272626008541 folate binding site [chemical binding]; other site 272626008542 NADP+ binding site [chemical binding]; other site 272626008543 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272626008544 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272626008545 putative NAD(P) binding site [chemical binding]; other site 272626008546 dimer interface [polypeptide binding]; other site 272626008547 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272626008548 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272626008549 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626008550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626008551 active site 272626008552 motif I; other site 272626008553 motif II; other site 272626008554 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 272626008555 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272626008556 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008557 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008558 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008559 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008560 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008561 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008562 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008563 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008564 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008565 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008566 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 272626008567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626008568 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626008569 Walker A/P-loop; other site 272626008570 ATP binding site [chemical binding]; other site 272626008571 Q-loop/lid; other site 272626008572 ABC transporter signature motif; other site 272626008573 Walker B; other site 272626008574 D-loop; other site 272626008575 H-loop/switch region; other site 272626008576 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272626008577 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272626008578 FtsX-like permease family; Region: FtsX; pfam02687 272626008579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272626008580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272626008581 dimerization interface [polypeptide binding]; other site 272626008582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626008583 dimer interface [polypeptide binding]; other site 272626008584 phosphorylation site [posttranslational modification] 272626008585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626008586 ATP binding site [chemical binding]; other site 272626008587 Mg2+ binding site [ion binding]; other site 272626008588 G-X-G motif; other site 272626008589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626008590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626008591 active site 272626008592 phosphorylation site [posttranslational modification] 272626008593 intermolecular recognition site; other site 272626008594 dimerization interface [polypeptide binding]; other site 272626008595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626008596 DNA binding site [nucleotide binding] 272626008597 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 272626008598 Uncharacterized conserved protein [Function unknown]; Region: COG2427 272626008599 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 272626008600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272626008601 catalytic loop [active] 272626008602 iron binding site [ion binding]; other site 272626008603 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272626008604 4Fe-4S binding domain; Region: Fer4; pfam00037 272626008605 4Fe-4S binding domain; Region: Fer4; pfam00037 272626008606 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 272626008607 [4Fe-4S] binding site [ion binding]; other site 272626008608 molybdopterin cofactor binding site; other site 272626008609 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 272626008610 molybdopterin cofactor binding site; other site 272626008611 Uncharacterized conserved protein [Function unknown]; Region: COG1912 272626008612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626008613 putative substrate translocation pore; other site 272626008614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626008615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626008616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626008617 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 272626008618 active site 272626008619 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 272626008620 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272626008621 Walker A motif; other site 272626008622 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626008623 SH3-like domain; Region: SH3_8; pfam13457 272626008624 SH3-like domain; Region: SH3_8; pfam13457 272626008625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626008626 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626008627 active site 272626008628 catalytic tetrad [active] 272626008629 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626008630 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272626008631 DNA binding residues [nucleotide binding] 272626008632 putative dimer interface [polypeptide binding]; other site 272626008633 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 272626008634 tetramer interface [polypeptide binding]; other site 272626008635 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 272626008636 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 272626008637 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 272626008638 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 272626008639 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272626008640 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272626008641 23S rRNA interface [nucleotide binding]; other site 272626008642 L3 interface [polypeptide binding]; other site 272626008643 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272626008644 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272626008645 dimerization interface 3.5A [polypeptide binding]; other site 272626008646 active site 272626008647 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272626008648 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 272626008649 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272626008650 Walker A/P-loop; other site 272626008651 ATP binding site [chemical binding]; other site 272626008652 Q-loop/lid; other site 272626008653 ABC transporter signature motif; other site 272626008654 Walker B; other site 272626008655 D-loop; other site 272626008656 H-loop/switch region; other site 272626008657 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 272626008658 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272626008659 Walker A/P-loop; other site 272626008660 ATP binding site [chemical binding]; other site 272626008661 Q-loop/lid; other site 272626008662 ABC transporter signature motif; other site 272626008663 Walker B; other site 272626008664 D-loop; other site 272626008665 H-loop/switch region; other site 272626008666 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 272626008667 MgtC family; Region: MgtC; pfam02308 272626008668 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 272626008669 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 272626008670 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272626008671 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272626008672 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272626008673 alphaNTD - beta interaction site [polypeptide binding]; other site 272626008674 alphaNTD homodimer interface [polypeptide binding]; other site 272626008675 alphaNTD - beta' interaction site [polypeptide binding]; other site 272626008676 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272626008677 30S ribosomal protein S11; Validated; Region: PRK05309 272626008678 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272626008679 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272626008680 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272626008681 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272626008682 rRNA binding site [nucleotide binding]; other site 272626008683 predicted 30S ribosome binding site; other site 272626008684 adenylate kinase; Reviewed; Region: adk; PRK00279 272626008685 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272626008686 AMP-binding site [chemical binding]; other site 272626008687 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272626008688 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272626008689 SecY translocase; Region: SecY; pfam00344 272626008690 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272626008691 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272626008692 23S rRNA binding site [nucleotide binding]; other site 272626008693 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272626008694 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272626008695 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272626008696 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272626008697 5S rRNA interface [nucleotide binding]; other site 272626008698 L27 interface [polypeptide binding]; other site 272626008699 23S rRNA interface [nucleotide binding]; other site 272626008700 L5 interface [polypeptide binding]; other site 272626008701 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272626008702 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272626008703 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272626008704 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272626008705 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272626008706 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272626008707 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272626008708 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272626008709 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272626008710 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272626008711 RNA binding site [nucleotide binding]; other site 272626008712 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272626008713 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272626008714 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272626008715 23S rRNA interface [nucleotide binding]; other site 272626008716 putative translocon interaction site; other site 272626008717 signal recognition particle (SRP54) interaction site; other site 272626008718 L23 interface [polypeptide binding]; other site 272626008719 trigger factor interaction site; other site 272626008720 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272626008721 23S rRNA interface [nucleotide binding]; other site 272626008722 5S rRNA interface [nucleotide binding]; other site 272626008723 putative antibiotic binding site [chemical binding]; other site 272626008724 L25 interface [polypeptide binding]; other site 272626008725 L27 interface [polypeptide binding]; other site 272626008726 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272626008727 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272626008728 G-X-X-G motif; other site 272626008729 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272626008730 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272626008731 putative translocon binding site; other site 272626008732 protein-rRNA interface [nucleotide binding]; other site 272626008733 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272626008734 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272626008735 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272626008736 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272626008737 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272626008738 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272626008739 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272626008740 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272626008741 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272626008742 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 272626008743 UbiA prenyltransferase family; Region: UbiA; pfam01040 272626008744 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272626008745 ApbE family; Region: ApbE; pfam02424 272626008746 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 272626008747 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 272626008748 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 272626008749 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272626008750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626008751 Predicted membrane protein [Function unknown]; Region: COG2259 272626008752 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 272626008753 trimer interface [polypeptide binding]; other site 272626008754 Predicted membrane protein [Function unknown]; Region: COG4769 272626008755 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272626008756 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272626008757 substrate binding pocket [chemical binding]; other site 272626008758 chain length determination region; other site 272626008759 substrate-Mg2+ binding site; other site 272626008760 catalytic residues [active] 272626008761 aspartate-rich region 1; other site 272626008762 active site lid residues [active] 272626008763 aspartate-rich region 2; other site 272626008764 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272626008765 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272626008766 active site 272626008767 metal binding site [ion binding]; metal-binding site 272626008768 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 272626008769 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 272626008770 hypothetical protein; Provisional; Region: PRK02947 272626008771 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626008772 putative active site [active] 272626008773 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 272626008774 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 272626008775 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272626008776 active site 272626008777 substrate binding pocket [chemical binding]; other site 272626008778 homodimer interaction site [polypeptide binding]; other site 272626008779 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272626008780 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272626008781 active site 272626008782 P-loop; other site 272626008783 phosphorylation site [posttranslational modification] 272626008784 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626008785 active site 272626008786 phosphorylation site [posttranslational modification] 272626008787 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626008788 Mga helix-turn-helix domain; Region: Mga; pfam05043 272626008789 PRD domain; Region: PRD; pfam00874 272626008790 PRD domain; Region: PRD; pfam00874 272626008791 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626008792 active site 272626008793 P-loop; other site 272626008794 phosphorylation site [posttranslational modification] 272626008795 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626008796 active site 272626008797 phosphorylation site [posttranslational modification] 272626008798 elongation factor Tu; Reviewed; Region: PRK00049 272626008799 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272626008800 G1 box; other site 272626008801 GEF interaction site [polypeptide binding]; other site 272626008802 GTP/Mg2+ binding site [chemical binding]; other site 272626008803 Switch I region; other site 272626008804 G2 box; other site 272626008805 G3 box; other site 272626008806 Switch II region; other site 272626008807 G4 box; other site 272626008808 G5 box; other site 272626008809 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272626008810 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272626008811 Antibiotic Binding Site [chemical binding]; other site 272626008812 elongation factor G; Reviewed; Region: PRK00007 272626008813 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272626008814 G1 box; other site 272626008815 putative GEF interaction site [polypeptide binding]; other site 272626008816 GTP/Mg2+ binding site [chemical binding]; other site 272626008817 Switch I region; other site 272626008818 G2 box; other site 272626008819 G3 box; other site 272626008820 Switch II region; other site 272626008821 G4 box; other site 272626008822 G5 box; other site 272626008823 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272626008824 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272626008825 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272626008826 30S ribosomal protein S7; Validated; Region: PRK05302 272626008827 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272626008828 S17 interaction site [polypeptide binding]; other site 272626008829 S8 interaction site; other site 272626008830 16S rRNA interaction site [nucleotide binding]; other site 272626008831 streptomycin interaction site [chemical binding]; other site 272626008832 23S rRNA interaction site [nucleotide binding]; other site 272626008833 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272626008834 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 272626008835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272626008836 Zn2+ binding site [ion binding]; other site 272626008837 Mg2+ binding site [ion binding]; other site 272626008838 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272626008839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626008840 Coenzyme A binding pocket [chemical binding]; other site 272626008841 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272626008842 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272626008843 substrate binding site [chemical binding]; other site 272626008844 hexamer interface [polypeptide binding]; other site 272626008845 metal binding site [ion binding]; metal-binding site 272626008846 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272626008847 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272626008848 TPP-binding site [chemical binding]; other site 272626008849 dimer interface [polypeptide binding]; other site 272626008850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272626008851 PYR/PP interface [polypeptide binding]; other site 272626008852 dimer interface [polypeptide binding]; other site 272626008853 TPP binding site [chemical binding]; other site 272626008854 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272626008855 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272626008856 substrate binding site [chemical binding]; other site 272626008857 hexamer interface [polypeptide binding]; other site 272626008858 metal binding site [ion binding]; metal-binding site 272626008859 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 272626008860 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272626008861 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 272626008862 putative NAD(P) binding site [chemical binding]; other site 272626008863 catalytic Zn binding site [ion binding]; other site 272626008864 structural Zn binding site [ion binding]; other site 272626008865 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272626008866 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 272626008867 putative NAD(P) binding site [chemical binding]; other site 272626008868 catalytic Zn binding site [ion binding]; other site 272626008869 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 272626008870 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272626008871 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 272626008872 active site 272626008873 P-loop; other site 272626008874 phosphorylation site [posttranslational modification] 272626008875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626008876 active site 272626008877 phosphorylation site [posttranslational modification] 272626008878 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272626008879 PRD domain; Region: PRD; pfam00874 272626008880 PRD domain; Region: PRD; pfam00874 272626008881 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272626008882 active site 272626008883 P-loop; other site 272626008884 phosphorylation site [posttranslational modification] 272626008885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626008886 active site 272626008887 phosphorylation site [posttranslational modification] 272626008888 Predicted membrane protein [Function unknown]; Region: COG4905 272626008889 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 272626008890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 272626008891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272626008892 Ligand Binding Site [chemical binding]; other site 272626008893 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272626008894 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272626008895 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272626008896 active site 272626008897 DNA binding site [nucleotide binding] 272626008898 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272626008899 similar to hydrolase (esterase) (truncated, C-terminal end) 272626008900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272626008901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626008902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626008903 active site 272626008904 phosphorylation site [posttranslational modification] 272626008905 intermolecular recognition site; other site 272626008906 dimerization interface [polypeptide binding]; other site 272626008907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626008908 DNA binding site [nucleotide binding] 272626008909 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272626008910 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272626008911 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272626008912 Ligand Binding Site [chemical binding]; other site 272626008913 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272626008914 GAF domain; Region: GAF_3; pfam13492 272626008915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626008916 dimer interface [polypeptide binding]; other site 272626008917 phosphorylation site [posttranslational modification] 272626008918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626008919 ATP binding site [chemical binding]; other site 272626008920 Mg2+ binding site [ion binding]; other site 272626008921 G-X-G motif; other site 272626008922 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 272626008923 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272626008924 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626008925 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272626008926 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626008927 active site 272626008928 P-loop; other site 272626008929 phosphorylation site [posttranslational modification] 272626008930 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626008931 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626008932 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626008933 methionine cluster; other site 272626008934 active site 272626008935 phosphorylation site [posttranslational modification] 272626008936 metal binding site [ion binding]; metal-binding site 272626008937 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272626008938 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272626008939 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 272626008940 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272626008941 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626008942 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272626008943 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272626008944 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272626008945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626008946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626008947 autolysin; Reviewed; Region: PRK06347 272626008948 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272626008949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272626008953 Protein of unknown function (DUF970); Region: DUF970; pfam06153 272626008954 thymidylate kinase; Validated; Region: tmk; PRK00698 272626008955 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272626008956 TMP-binding site; other site 272626008957 ATP-binding site [chemical binding]; other site 272626008958 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 272626008959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272626008960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626008961 catalytic residue [active] 272626008962 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272626008963 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272626008964 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272626008965 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272626008966 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272626008967 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 272626008968 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272626008969 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272626008970 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626008971 putative active site [active] 272626008972 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272626008973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626008974 active site 272626008975 motif I; other site 272626008976 motif II; other site 272626008977 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272626008978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272626008979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272626008980 active site 272626008981 catalytic tetrad [active] 272626008982 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 272626008983 recombination protein RecR; Reviewed; Region: recR; PRK00076 272626008984 RecR protein; Region: RecR; pfam02132 272626008985 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272626008986 putative active site [active] 272626008987 putative metal-binding site [ion binding]; other site 272626008988 tetramer interface [polypeptide binding]; other site 272626008989 hypothetical protein; Validated; Region: PRK00153 272626008990 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272626008991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626008992 Walker A motif; other site 272626008993 ATP binding site [chemical binding]; other site 272626008994 Walker B motif; other site 272626008995 arginine finger; other site 272626008996 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272626008997 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 272626008998 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 272626008999 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626009000 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626009001 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272626009002 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272626009003 N- and C-terminal domain interface [polypeptide binding]; other site 272626009004 active site 272626009005 catalytic site [active] 272626009006 metal binding site [ion binding]; metal-binding site 272626009007 carbohydrate binding site [chemical binding]; other site 272626009008 ATP binding site [chemical binding]; other site 272626009009 SH3-like domain; Region: SH3_8; pfam13457 272626009010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 272626009011 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 272626009012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626009013 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 272626009014 Walker A/P-loop; other site 272626009015 ATP binding site [chemical binding]; other site 272626009016 Q-loop/lid; other site 272626009017 ABC transporter signature motif; other site 272626009018 Walker B; other site 272626009019 D-loop; other site 272626009020 H-loop/switch region; other site 272626009021 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272626009022 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626009023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626009024 Walker A/P-loop; other site 272626009025 ATP binding site [chemical binding]; other site 272626009026 Q-loop/lid; other site 272626009027 ABC transporter signature motif; other site 272626009028 Walker B; other site 272626009029 D-loop; other site 272626009030 H-loop/switch region; other site 272626009031 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272626009032 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272626009033 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272626009034 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272626009035 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272626009036 nucleoside/Zn binding site; other site 272626009037 dimer interface [polypeptide binding]; other site 272626009038 catalytic motif [active] 272626009039 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 272626009040 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 272626009041 active site 272626009042 acyl-activating enzyme (AAE) consensus motif; other site 272626009043 putative CoA binding site [chemical binding]; other site 272626009044 AMP binding site [chemical binding]; other site 272626009045 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272626009046 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272626009047 active site 272626009048 trimer interface [polypeptide binding]; other site 272626009049 allosteric site; other site 272626009050 active site lid [active] 272626009051 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272626009052 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626009053 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 272626009054 DNA binding residues [nucleotide binding] 272626009055 drug binding residues [chemical binding]; other site 272626009056 dimer interface [polypeptide binding]; other site 272626009057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272626009058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626009059 Coenzyme A binding pocket [chemical binding]; other site 272626009060 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272626009061 dimer interface [polypeptide binding]; other site 272626009062 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272626009063 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272626009064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272626009065 MarR family; Region: MarR; pfam01047 272626009066 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 272626009067 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272626009068 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272626009069 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272626009070 DNA binding residues [nucleotide binding] 272626009071 putative dimer interface [polypeptide binding]; other site 272626009072 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272626009073 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272626009074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626009075 active site 272626009076 motif I; other site 272626009077 motif II; other site 272626009078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626009079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626009080 DNA binding site [nucleotide binding] 272626009081 domain linker motif; other site 272626009082 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 272626009083 putative dimerization interface [polypeptide binding]; other site 272626009084 putative ligand binding site [chemical binding]; other site 272626009085 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272626009086 Domain of unknown function DUF21; Region: DUF21; pfam01595 272626009087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272626009088 Transporter associated domain; Region: CorC_HlyC; pfam03471 272626009089 NAD-dependent deacetylase; Provisional; Region: PRK00481 272626009090 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 272626009091 NAD+ binding site [chemical binding]; other site 272626009092 substrate binding site [chemical binding]; other site 272626009093 putative Zn binding site [ion binding]; other site 272626009094 Pathogenicity locus; Region: Cdd1; pfam11731 272626009095 drug efflux system protein MdtG; Provisional; Region: PRK09874 272626009096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009097 putative substrate translocation pore; other site 272626009098 Variant SH3 domain; Region: SH3_2; pfam07653 272626009099 peptide ligand binding site [polypeptide binding]; other site 272626009100 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272626009101 active site 272626009102 intersubunit interactions; other site 272626009103 catalytic residue [active] 272626009104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272626009105 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272626009106 ligand binding site [chemical binding]; other site 272626009107 flexible hinge region; other site 272626009108 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272626009109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626009110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626009111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626009112 Walker A/P-loop; other site 272626009113 ATP binding site [chemical binding]; other site 272626009114 Q-loop/lid; other site 272626009115 ABC transporter signature motif; other site 272626009116 Walker B; other site 272626009117 D-loop; other site 272626009118 H-loop/switch region; other site 272626009119 TfoX C-terminal domain; Region: TfoX_C; pfam04994 272626009120 seryl-tRNA synthetase; Provisional; Region: PRK05431 272626009121 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272626009122 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272626009123 dimer interface [polypeptide binding]; other site 272626009124 active site 272626009125 motif 1; other site 272626009126 motif 2; other site 272626009127 motif 3; other site 272626009128 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 272626009129 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272626009130 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272626009131 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272626009132 glutamine binding [chemical binding]; other site 272626009133 catalytic triad [active] 272626009134 aminodeoxychorismate synthase; Provisional; Region: PRK07508 272626009135 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272626009136 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 272626009137 substrate-cofactor binding pocket; other site 272626009138 homodimer interface [polypeptide binding]; other site 272626009139 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272626009140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272626009141 catalytic residue [active] 272626009142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626009143 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626009144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626009145 Walker A/P-loop; other site 272626009146 ATP binding site [chemical binding]; other site 272626009147 Q-loop/lid; other site 272626009148 ABC transporter signature motif; other site 272626009149 Walker B; other site 272626009150 D-loop; other site 272626009151 H-loop/switch region; other site 272626009152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272626009153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272626009154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272626009155 Walker A/P-loop; other site 272626009156 ATP binding site [chemical binding]; other site 272626009157 Q-loop/lid; other site 272626009158 ABC transporter signature motif; other site 272626009159 Walker B; other site 272626009160 D-loop; other site 272626009161 H-loop/switch region; other site 272626009162 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272626009163 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272626009164 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272626009165 Predicted acyl esterases [General function prediction only]; Region: COG2936 272626009166 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 272626009167 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272626009168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626009169 ATP binding site [chemical binding]; other site 272626009170 putative Mg++ binding site [ion binding]; other site 272626009171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626009172 nucleotide binding region [chemical binding]; other site 272626009173 ATP-binding site [chemical binding]; other site 272626009174 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272626009175 HRDC domain; Region: HRDC; pfam00570 272626009176 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 272626009177 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272626009178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272626009179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272626009180 active site 272626009181 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 272626009182 putative ADP-ribose binding site [chemical binding]; other site 272626009183 putative active site [active] 272626009184 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272626009185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626009186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626009187 ABC transporter; Region: ABC_tran_2; pfam12848 272626009188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272626009189 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272626009190 beta-galactosidase; Region: BGL; TIGR03356 272626009191 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272626009192 active site 272626009193 P-loop; other site 272626009194 phosphorylation site [posttranslational modification] 272626009195 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272626009196 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272626009197 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626009198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626009199 nucleotide binding site [chemical binding]; other site 272626009200 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272626009201 methionine cluster; other site 272626009202 active site 272626009203 phosphorylation site [posttranslational modification] 272626009204 metal binding site [ion binding]; metal-binding site 272626009205 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272626009206 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272626009207 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626009208 putative active site [active] 272626009209 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 272626009210 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272626009211 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272626009212 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626009213 Walker A/P-loop; other site 272626009214 ATP binding site [chemical binding]; other site 272626009215 Q-loop/lid; other site 272626009216 ABC transporter signature motif; other site 272626009217 Walker B; other site 272626009218 D-loop; other site 272626009219 H-loop/switch region; other site 272626009220 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG2918 272626009221 glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; Region: glu_cys_lig_rel; TIGR01435 272626009222 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272626009223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272626009224 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272626009225 Walker A/P-loop; other site 272626009226 ATP binding site [chemical binding]; other site 272626009227 Q-loop/lid; other site 272626009228 ABC transporter signature motif; other site 272626009229 Walker B; other site 272626009230 D-loop; other site 272626009231 H-loop/switch region; other site 272626009232 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 272626009233 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 272626009234 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272626009235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009236 putative substrate translocation pore; other site 272626009237 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 272626009238 GTP-binding protein YchF; Reviewed; Region: PRK09601 272626009239 YchF GTPase; Region: YchF; cd01900 272626009240 G1 box; other site 272626009241 GTP/Mg2+ binding site [chemical binding]; other site 272626009242 Switch I region; other site 272626009243 G2 box; other site 272626009244 Switch II region; other site 272626009245 G3 box; other site 272626009246 G4 box; other site 272626009247 G5 box; other site 272626009248 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272626009249 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 272626009250 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 272626009251 tetramer interface [polypeptide binding]; other site 272626009252 heme binding pocket [chemical binding]; other site 272626009253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 272626009254 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272626009255 ParB-like nuclease domain; Region: ParB; smart00470 272626009256 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 272626009257 salt bridge; other site 272626009258 non-specific DNA binding site [nucleotide binding]; other site 272626009259 sequence-specific DNA binding site [nucleotide binding]; other site 272626009260 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272626009261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272626009262 P-loop; other site 272626009263 Magnesium ion binding site [ion binding]; other site 272626009264 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272626009265 Magnesium ion binding site [ion binding]; other site 272626009266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272626009267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272626009268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626009269 non-specific DNA binding site [nucleotide binding]; other site 272626009270 salt bridge; other site 272626009271 sequence-specific DNA binding site [nucleotide binding]; other site 272626009272 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 272626009273 ParB-like nuclease domain; Region: ParBc; pfam02195 272626009274 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272626009275 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272626009276 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272626009277 putative active site [active] 272626009278 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272626009279 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272626009280 nucleotide binding site [chemical binding]; other site 272626009281 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272626009282 active site 272626009283 phosphorylation site [posttranslational modification] 272626009284 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272626009285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626009286 motif II; other site 272626009287 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272626009288 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272626009289 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272626009290 active site 272626009291 P-loop; other site 272626009292 phosphorylation site [posttranslational modification] 272626009293 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626009294 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626009295 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272626009296 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272626009297 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 272626009298 putative active site cavity [active] 272626009299 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272626009300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272626009301 S-adenosylmethionine binding site [chemical binding]; other site 272626009302 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 272626009303 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 272626009304 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 272626009305 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 272626009306 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272626009307 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272626009308 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272626009309 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272626009310 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272626009311 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272626009312 G1 box; other site 272626009313 GTP/Mg2+ binding site [chemical binding]; other site 272626009314 Switch I region; other site 272626009315 G2 box; other site 272626009316 Switch II region; other site 272626009317 G3 box; other site 272626009318 G4 box; other site 272626009319 G5 box; other site 272626009320 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272626009321 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272626009322 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272626009323 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 272626009324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272626009325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272626009326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272626009327 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 272626009328 NADP binding site [chemical binding]; other site 272626009329 homodimer interface [polypeptide binding]; other site 272626009330 active site 272626009331 substrate binding site [chemical binding]; other site 272626009332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009333 D-galactonate transporter; Region: 2A0114; TIGR00893 272626009334 putative substrate translocation pore; other site 272626009335 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272626009336 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272626009337 metal binding site [ion binding]; metal-binding site 272626009338 dimer interface [polypeptide binding]; other site 272626009339 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272626009340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 272626009341 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272626009342 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272626009343 metal binding site [ion binding]; metal-binding site 272626009344 dimer interface [polypeptide binding]; other site 272626009345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626009346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272626009347 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 272626009348 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272626009349 Uncharacterized conserved protein [Function unknown]; Region: COG4198 272626009350 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 272626009351 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 272626009352 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272626009353 putative ligand binding site [chemical binding]; other site 272626009354 putative NAD binding site [chemical binding]; other site 272626009355 putative catalytic site [active] 272626009356 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272626009357 L-serine binding site [chemical binding]; other site 272626009358 ACT domain interface; other site 272626009359 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 272626009360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272626009361 catalytic residue [active] 272626009362 similar to efflux proteins (truncated, N-terminal end) 272626009363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626009365 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272626009366 MarR family; Region: MarR_2; pfam12802 272626009367 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 272626009368 dimer interface [polypeptide binding]; other site 272626009369 FMN binding site [chemical binding]; other site 272626009370 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272626009371 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272626009372 catalytic residues [active] 272626009373 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272626009374 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272626009375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272626009376 motif II; other site 272626009377 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272626009378 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 272626009379 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272626009380 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272626009381 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272626009382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272626009383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272626009384 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272626009385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272626009386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272626009387 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 272626009388 putative NAD(P) binding site [chemical binding]; other site 272626009389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272626009390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626009391 dimer interface [polypeptide binding]; other site 272626009392 conserved gate region; other site 272626009393 putative PBP binding loops; other site 272626009394 ABC-ATPase subunit interface; other site 272626009395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272626009396 dimer interface [polypeptide binding]; other site 272626009397 conserved gate region; other site 272626009398 putative PBP binding loops; other site 272626009399 ABC-ATPase subunit interface; other site 272626009400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272626009401 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272626009402 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 272626009403 sucrose phosphorylase; Provisional; Region: PRK13840 272626009404 active site 272626009405 homodimer interface [polypeptide binding]; other site 272626009406 catalytic site [active] 272626009407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272626009408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272626009409 DNA binding site [nucleotide binding] 272626009410 domain linker motif; other site 272626009411 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 272626009412 putative dimerization interface [polypeptide binding]; other site 272626009413 putative ligand binding site [chemical binding]; other site 272626009414 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 272626009415 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272626009416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272626009417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272626009418 Coenzyme A binding pocket [chemical binding]; other site 272626009419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626009421 putative substrate translocation pore; other site 272626009422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009423 Domain of unknown function (DUF718); Region: DUF718; cl01281 272626009424 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 272626009425 intersubunit interface [polypeptide binding]; other site 272626009426 active site 272626009427 Zn2+ binding site [ion binding]; other site 272626009428 L-rhamnose isomerase; Provisional; Region: PRK01076 272626009429 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 272626009430 N- and C-terminal domain interface [polypeptide binding]; other site 272626009431 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 272626009432 active site 272626009433 putative catalytic site [active] 272626009434 metal binding site [ion binding]; metal-binding site 272626009435 ATP binding site [chemical binding]; other site 272626009436 carbohydrate binding site [chemical binding]; other site 272626009437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272626009438 putative substrate translocation pore; other site 272626009439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272626009440 Cupin domain; Region: Cupin_2; pfam07883 272626009441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272626009442 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272626009443 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 272626009444 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 272626009445 G-X-X-G motif; other site 272626009446 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 272626009447 RxxxH motif; other site 272626009448 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 272626009449 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 272626009450 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272626009451 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272626009452 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 272626009453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272626009454 Walker A motif; other site 272626009455 ATP binding site [chemical binding]; other site 272626009456 Walker B motif; other site 272626009457 arginine finger; other site 272626009458 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 272626009459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272626009460 Integrase core domain; Region: rve; pfam00665 272626009461 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272626009462 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272626009463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272626009464 non-specific DNA binding site [nucleotide binding]; other site 272626009465 salt bridge; other site 272626009466 sequence-specific DNA binding site [nucleotide binding]; other site 272626009467 Fic family protein [Function unknown]; Region: COG3177 272626009468 Fic/DOC family; Region: Fic; pfam02661 272626009469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009470 Integrase core domain; Region: rve; pfam00665 272626009471 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272626009472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272626009473 active site 272626009474 Plasmid rolling circle replication initiator protein and truncated derivatives [DNA replication, recombination, and repair]; Region: COG5655 272626009475 Replication protein; Region: Rep_1; cl02412 272626009476 similar to transposase C-terminal part 272626009477 transposase (truncated) 272626009478 Transposase, truncated 272626009479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009480 Integrase core domain; Region: rve; pfam00665 272626009481 Predicted helicase [General function prediction only]; Region: COG4889 272626009482 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 272626009483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626009484 ATP binding site [chemical binding]; other site 272626009485 putative Mg++ binding site [ion binding]; other site 272626009486 nucleotide binding region [chemical binding]; other site 272626009487 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 272626009488 ATP-binding site [chemical binding]; other site 272626009489 HTH domain; Region: HTH_11; cl17392 272626009490 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 272626009491 Initiator Replication protein; Region: Rep_3; pfam01051 272626009492 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 272626009493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009494 Integrase core domain; Region: rve; pfam00665 272626009495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272626009496 Transposase; Region: HTH_Tnp_1; pfam01527 272626009497 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 272626009498 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272626009499 putative active site [active] 272626009500 catalytic site [active] 272626009501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272626009502 ATP binding site [chemical binding]; other site 272626009503 putative Mg++ binding site [ion binding]; other site 272626009504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272626009505 nucleotide binding region [chemical binding]; other site 272626009506 ATP-binding site [chemical binding]; other site 272626009507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009508 Integrase core domain; Region: rve; pfam00665 272626009509 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272626009510 DNA methylase; Region: N6_N4_Mtase; pfam01555 272626009511 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 272626009512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009513 Integrase core domain; Region: rve; pfam00665 272626009514 Pseudogene, similar to C-terminal part of ATPase 272626009515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626009516 dimerization interface [polypeptide binding]; other site 272626009517 putative DNA binding site [nucleotide binding]; other site 272626009518 putative Zn2+ binding site [ion binding]; other site 272626009519 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272626009520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626009521 dimerization interface [polypeptide binding]; other site 272626009522 putative DNA binding site [nucleotide binding]; other site 272626009523 putative Zn2+ binding site [ion binding]; other site 272626009524 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 272626009525 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272626009526 P loop; other site 272626009527 Nucleotide binding site [chemical binding]; other site 272626009528 DTAP/Switch II; other site 272626009529 Switch I; other site 272626009530 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272626009531 DTAP/Switch II; other site 272626009532 Switch I; other site 272626009533 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272626009534 Sodium Bile acid symporter family; Region: SBF; cl17470 272626009535 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 272626009536 arsenical-resistance protein; Region: acr3; TIGR00832 272626009537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272626009538 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 272626009539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626009540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626009541 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 272626009542 active site residue [active] 272626009543 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272626009544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272626009545 Walker A/P-loop; other site 272626009546 ATP binding site [chemical binding]; other site 272626009547 Q-loop/lid; other site 272626009548 ABC transporter signature motif; other site 272626009549 Walker B; other site 272626009550 D-loop; other site 272626009551 H-loop/switch region; other site 272626009552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009554 Integrase core domain; Region: rve; pfam00665 272626009555 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272626009556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272626009557 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272626009558 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 272626009559 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272626009560 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 272626009561 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272626009562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626009563 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272626009564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009565 Integrase core domain; Region: rve; pfam00665 272626009566 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 272626009567 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272626009568 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272626009569 Ligand Binding Site [chemical binding]; other site 272626009570 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272626009571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272626009572 dimer interface [polypeptide binding]; other site 272626009573 phosphorylation site [posttranslational modification] 272626009574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272626009575 ATP binding site [chemical binding]; other site 272626009576 Mg2+ binding site [ion binding]; other site 272626009577 G-X-G motif; other site 272626009578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272626009579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272626009580 active site 272626009581 phosphorylation site [posttranslational modification] 272626009582 intermolecular recognition site; other site 272626009583 dimerization interface [polypeptide binding]; other site 272626009584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272626009585 DNA binding site [nucleotide binding] 272626009586 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272626009587 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272626009588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626009589 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272626009590 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 272626009591 potassium-transporting ATPase subunit C; Provisional; Region: PRK13995 272626009592 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272626009593 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272626009594 catalytic residues [active] 272626009595 catalytic nucleophile [active] 272626009596 Presynaptic Site I dimer interface [polypeptide binding]; other site 272626009597 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272626009598 Synaptic Flat tetramer interface [polypeptide binding]; other site 272626009599 Synaptic Site I dimer interface [polypeptide binding]; other site 272626009600 DNA binding site [nucleotide binding] 272626009601 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272626009602 DNA-binding interface [nucleotide binding]; DNA binding site 272626009603 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 272626009604 Winged helix-turn helix; Region: HTH_29; pfam13551 272626009605 Helix-turn-helix domain; Region: HTH_28; pfam13518 272626009606 Integrase core domain; Region: rve; pfam00665 272626009607 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 272626009608 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272626009609 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272626009610 catalytic residues [active] 272626009611 catalytic nucleophile [active] 272626009612 Presynaptic Site I dimer interface [polypeptide binding]; other site 272626009613 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272626009614 Synaptic Flat tetramer interface [polypeptide binding]; other site 272626009615 Synaptic Site I dimer interface [polypeptide binding]; other site 272626009616 DNA binding site [nucleotide binding] 272626009617 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 272626009618 DNA-binding interface [nucleotide binding]; DNA binding site 272626009619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272626009620 dimerization interface [polypeptide binding]; other site 272626009621 putative DNA binding site [nucleotide binding]; other site 272626009622 putative Zn2+ binding site [ion binding]; other site 272626009623 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272626009624 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272626009625 metal-binding site [ion binding] 272626009626 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272626009627 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272626009628 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272626009629 DNA binding site [nucleotide binding] 272626009630 Int/Topo IB signature motif; other site 272626009631 active site 272626009632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009633 Integrase core domain; Region: rve; pfam00665 272626009634 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 272626009635 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272626009636 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272626009637 active site 272626009638 DNA binding site [nucleotide binding] 272626009639 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272626009640 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272626009641 P-loop; other site 272626009642 Magnesium ion binding site [ion binding]; other site 272626009643 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272626009644 Magnesium ion binding site [ion binding]; other site 272626009645 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 272626009646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272626009647 Integrase core domain; Region: rve; pfam00665 272626009648 putative transposase OrfB; Reviewed; Region: PHA02517 272626009649 HTH-like domain; Region: HTH_21; pfam13276 272626009650 Integrase core domain; Region: rve; pfam00665 272626009651 Integrase core domain; Region: rve_3; pfam13683 272626009652 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 272626009653 non-specific DNA binding site [nucleotide binding]; other site 272626009654 salt bridge; other site 272626009655 sequence-specific DNA binding site [nucleotide binding]; other site 272626009656 putative transposase OrfB; Reviewed; Region: PHA02517 272626009657 HTH-like domain; Region: HTH_21; pfam13276 272626009658 Integrase core domain; Region: rve; pfam00665 272626009659 Integrase core domain; Region: rve_3; pfam13683 272626009660 Transposase; Region: HTH_Tnp_1; pfam01527 272626009661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272626009662 similar to enolase (phosphopyruvate hydratase), C-terminal end 272626009663 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272626009664 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272626009665 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313