-- dump date 20140619_132054 -- class Genbank::misc_feature -- table misc_feature_note -- id note 881621000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 881621000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 881621000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000004 Walker A motif; other site 881621000005 ATP binding site [chemical binding]; other site 881621000006 Walker B motif; other site 881621000007 arginine finger; other site 881621000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 881621000009 DnaA box-binding interface [nucleotide binding]; other site 881621000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 881621000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 881621000012 putative DNA binding surface [nucleotide binding]; other site 881621000013 dimer interface [polypeptide binding]; other site 881621000014 beta-clamp/clamp loader binding surface; other site 881621000015 beta-clamp/translesion DNA polymerase binding surface; other site 881621000016 similar to unknown protein, C-terminal part 881621000017 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 881621000018 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 881621000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 881621000020 Walker A/P-loop; other site 881621000021 ATP binding site [chemical binding]; other site 881621000022 Q-loop/lid; other site 881621000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621000024 ABC transporter signature motif; other site 881621000025 Walker B; other site 881621000026 D-loop; other site 881621000027 H-loop/switch region; other site 881621000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 881621000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000030 Mg2+ binding site [ion binding]; other site 881621000031 G-X-G motif; other site 881621000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 881621000033 anchoring element; other site 881621000034 dimer interface [polypeptide binding]; other site 881621000035 ATP binding site [chemical binding]; other site 881621000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621000037 active site 881621000038 putative metal-binding site [ion binding]; other site 881621000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621000040 DNA gyrase subunit A; Validated; Region: PRK05560 881621000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 881621000042 CAP-like domain; other site 881621000043 active site 881621000044 primary dimer interface [polypeptide binding]; other site 881621000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000050 cardiolipin synthetase; Reviewed; Region: PRK12452 881621000051 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621000052 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621000053 putative active site [active] 881621000054 catalytic site [active] 881621000055 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621000056 putative active site [active] 881621000057 catalytic site [active] 881621000058 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621000059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 881621000060 Coenzyme A binding pocket [chemical binding]; other site 881621000061 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 881621000062 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621000063 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000064 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 881621000065 diphosphomevalonate decarboxylase; Region: PLN02407 881621000066 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 881621000067 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621000068 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 881621000069 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 881621000070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 881621000071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 881621000072 D-pathway; other site 881621000073 Putative ubiquinol binding site [chemical binding]; other site 881621000074 Low-spin heme (heme b) binding site [chemical binding]; other site 881621000075 Putative water exit pathway; other site 881621000076 Binuclear center (heme o3/CuB) [ion binding]; other site 881621000077 K-pathway; other site 881621000078 Putative proton exit pathway; other site 881621000079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 881621000080 Subunit I/III interface [polypeptide binding]; other site 881621000081 Subunit III/IV interface [polypeptide binding]; other site 881621000082 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 881621000083 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000084 beta-galactosidase; Region: BGL; TIGR03356 881621000085 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621000086 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 881621000087 putative active site [active] 881621000088 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 881621000089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000090 active site turn [active] 881621000091 phosphorylation site [posttranslational modification] 881621000092 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621000093 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621000094 HPr interaction site; other site 881621000095 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000096 active site 881621000097 phosphorylation site [posttranslational modification] 881621000098 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621000099 putative dimer interface [polypeptide binding]; other site 881621000100 catalytic triad [active] 881621000101 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621000102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621000103 Walker A/P-loop; other site 881621000104 ATP binding site [chemical binding]; other site 881621000105 Q-loop/lid; other site 881621000106 ABC transporter signature motif; other site 881621000107 Walker B; other site 881621000108 D-loop; other site 881621000109 H-loop/switch region; other site 881621000110 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 881621000111 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 881621000112 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000114 active site 881621000115 motif I; other site 881621000116 motif II; other site 881621000117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000120 DNA binding site [nucleotide binding] 881621000121 domain linker motif; other site 881621000122 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 881621000123 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000124 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621000125 nucleotide binding site [chemical binding]; other site 881621000126 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 881621000127 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 881621000128 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621000129 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621000130 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621000131 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621000132 dimer interface [polypeptide binding]; other site 881621000133 active site 881621000134 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621000135 dimer interface [polypeptide binding]; other site 881621000136 active site 881621000137 putrescine carbamoyltransferase; Provisional; Region: PRK02255 881621000138 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621000139 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 881621000140 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 881621000141 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 881621000142 agmatine deiminase; Provisional; Region: PRK13551 881621000143 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000144 carbamate kinase; Reviewed; Region: PRK12686 881621000145 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 881621000146 putative substrate binding site [chemical binding]; other site 881621000147 nucleotide binding site [chemical binding]; other site 881621000148 nucleotide binding site [chemical binding]; other site 881621000149 homodimer interface [polypeptide binding]; other site 881621000150 agmatine deiminase; Provisional; Region: PRK13551 881621000151 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000152 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621000153 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621000154 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621000155 putative active site [active] 881621000156 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621000157 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 881621000158 arginine deiminase; Provisional; Region: PRK01388 881621000159 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 881621000160 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 881621000161 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621000162 dimer interface [polypeptide binding]; other site 881621000163 ssDNA binding site [nucleotide binding]; other site 881621000164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000165 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 881621000166 Predicted membrane protein [Function unknown]; Region: COG3212 881621000167 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621000168 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621000169 putative accessory gene regulator protein; Provisional; Region: PRK01100 881621000170 Staphylococcal AgrD protein; Region: AgrD; cl05477 881621000171 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621000172 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 881621000173 ATP binding site [chemical binding]; other site 881621000174 Mg2+ binding site [ion binding]; other site 881621000175 G-X-G motif; other site 881621000176 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 881621000177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621000178 active site 881621000179 phosphorylation site [posttranslational modification] 881621000180 intermolecular recognition site; other site 881621000181 dimerization interface [polypeptide binding]; other site 881621000182 LytTr DNA-binding domain; Region: LytTR; pfam04397 881621000183 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 881621000184 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 881621000185 DHH family; Region: DHH; pfam01368 881621000186 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 881621000187 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 881621000188 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 881621000189 replicative DNA helicase; Provisional; Region: PRK05748 881621000190 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 881621000191 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 881621000192 Walker A motif; other site 881621000193 ATP binding site [chemical binding]; other site 881621000194 Walker B motif; other site 881621000195 DNA binding loops [nucleotide binding] 881621000196 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 881621000197 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 881621000198 GDP-binding site [chemical binding]; other site 881621000199 ACT binding site; other site 881621000200 IMP binding site; other site 881621000201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 881621000202 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621000203 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 881621000204 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 881621000205 Uncharacterized small protein [Function unknown]; Region: COG5417 881621000206 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, N-terminal part 881621000207 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, C-terminal part 881621000208 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 881621000209 Uncharacterized conserved protein [Function unknown]; Region: COG5444 881621000210 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 881621000211 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 881621000212 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 881621000213 tetramer interface [polypeptide binding]; other site 881621000214 active site 881621000215 Mg2+/Mn2+ binding site [ion binding]; other site 881621000216 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621000217 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621000218 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 881621000219 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621000220 DNA binding site [nucleotide binding] 881621000221 active site 881621000222 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 881621000223 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 881621000224 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 881621000225 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 881621000226 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 881621000227 putative ligand binding site [chemical binding]; other site 881621000228 putative NAD binding site [chemical binding]; other site 881621000229 catalytic site [active] 881621000230 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621000231 active site 881621000232 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000233 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621000234 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000235 SH3-like domain; Region: SH3_8; pfam13457 881621000236 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621000238 Leucine rich repeat; Region: LRR_8; pfam13855 881621000239 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000240 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 881621000241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621000242 DNA-binding site [nucleotide binding]; DNA binding site 881621000243 UTRA domain; Region: UTRA; pfam07702 881621000244 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 881621000245 putative active site [active] 881621000246 YdjC motif; other site 881621000247 Mg binding site [ion binding]; other site 881621000248 putative homodimer interface [polypeptide binding]; other site 881621000249 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 881621000250 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621000251 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000252 active site turn [active] 881621000253 phosphorylation site [posttranslational modification] 881621000254 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621000255 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 881621000256 NAD(P) binding site [chemical binding]; other site 881621000257 LDH/MDH dimer interface [polypeptide binding]; other site 881621000258 substrate binding site [chemical binding]; other site 881621000259 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 881621000260 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 881621000261 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 881621000262 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 881621000263 intersubunit interface [polypeptide binding]; other site 881621000264 active site 881621000265 Zn2+ binding site [ion binding]; other site 881621000266 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 881621000267 N- and C-terminal domain interface [polypeptide binding]; other site 881621000268 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 881621000269 active site 881621000270 putative catalytic site [active] 881621000271 metal binding site [ion binding]; metal-binding site 881621000272 ATP binding site [chemical binding]; other site 881621000273 carbohydrate binding site [chemical binding]; other site 881621000274 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 881621000275 L-fucose isomerase; Provisional; Region: fucI; PRK10991 881621000276 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 881621000277 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621000278 trimer interface [polypeptide binding]; other site 881621000279 substrate binding site [chemical binding]; other site 881621000280 Mn binding site [ion binding]; other site 881621000281 Ion channel; Region: Ion_trans_2; pfam07885 881621000282 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621000283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000284 non-specific DNA binding site [nucleotide binding]; other site 881621000285 salt bridge; other site 881621000286 sequence-specific DNA binding site [nucleotide binding]; other site 881621000287 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621000288 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 881621000289 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621000290 active pocket/dimerization site; other site 881621000291 active site 881621000292 phosphorylation site [posttranslational modification] 881621000293 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 881621000294 active site 881621000295 phosphorylation site [posttranslational modification] 881621000296 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 881621000297 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 881621000298 Domain of unknown function (DUF956); Region: DUF956; pfam06115 881621000299 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 881621000300 Cupin domain; Region: Cupin_2; pfam07883 881621000301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000303 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000304 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 881621000305 active site turn [active] 881621000306 phosphorylation site [posttranslational modification] 881621000307 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621000308 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 881621000309 beta-galactosidase; Region: BGL; TIGR03356 881621000310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000311 dimerization interface [polypeptide binding]; other site 881621000312 putative DNA binding site [nucleotide binding]; other site 881621000313 Uncharacterized conserved protein [Function unknown]; Region: COG1359 881621000314 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 881621000315 dimer interface [polypeptide binding]; other site 881621000316 FMN binding site [chemical binding]; other site 881621000317 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 881621000318 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 881621000319 active site 881621000320 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 881621000321 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 881621000322 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 881621000323 aromatic chitin/cellulose binding site residues [chemical binding]; other site 881621000324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621000326 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 881621000327 Walker A/P-loop; other site 881621000328 ATP binding site [chemical binding]; other site 881621000329 Q-loop/lid; other site 881621000330 ABC transporter signature motif; other site 881621000331 Walker B; other site 881621000332 D-loop; other site 881621000333 H-loop/switch region; other site 881621000334 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621000336 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 881621000337 Walker A/P-loop; other site 881621000338 ATP binding site [chemical binding]; other site 881621000339 Q-loop/lid; other site 881621000340 ABC transporter signature motif; other site 881621000341 Walker B; other site 881621000342 D-loop; other site 881621000343 H-loop/switch region; other site 881621000344 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 881621000345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000348 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 881621000349 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621000350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 881621000351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000352 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000354 ligand binding site [chemical binding]; other site 881621000355 flexible hinge region; other site 881621000356 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621000357 Domain of unknown function (DUF955); Region: DUF955; pfam06114 881621000358 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621000359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000360 non-specific DNA binding site [nucleotide binding]; other site 881621000361 salt bridge; other site 881621000362 sequence-specific DNA binding site [nucleotide binding]; other site 881621000363 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 881621000364 Holin family; Region: Phage_holin_4; cl01989 881621000365 Similar to autolysin: N-acetylmuramoyl-L-alanine amidase 881621000366 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621000367 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 881621000368 putative active site [active] 881621000369 putative metal binding site [ion binding]; other site 881621000370 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621000371 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000372 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 881621000373 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 881621000374 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 881621000375 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 881621000376 active site 881621000377 Uncharacterized conserved protein [Function unknown]; Region: COG3592 881621000378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000379 Coenzyme A binding pocket [chemical binding]; other site 881621000380 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 881621000381 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 881621000382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621000383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000384 dimer interface [polypeptide binding]; other site 881621000385 conserved gate region; other site 881621000386 putative PBP binding loops; other site 881621000387 ABC-ATPase subunit interface; other site 881621000388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000389 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 881621000390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000391 dimer interface [polypeptide binding]; other site 881621000392 conserved gate region; other site 881621000393 putative PBP binding loops; other site 881621000394 ABC-ATPase subunit interface; other site 881621000395 similar to unknown protein, partial 881621000396 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000397 peptide binding site [polypeptide binding]; other site 881621000398 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 881621000399 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 881621000400 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621000401 metal binding site [ion binding]; metal-binding site 881621000402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000403 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 881621000404 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 881621000405 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621000406 ABC-ATPase subunit interface; other site 881621000407 dimer interface [polypeptide binding]; other site 881621000408 putative PBP binding regions; other site 881621000409 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000411 ligand binding site [chemical binding]; other site 881621000412 flexible hinge region; other site 881621000413 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621000414 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 881621000415 DEAD_2; Region: DEAD_2; pfam06733 881621000416 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 881621000417 sugar phosphate phosphatase; Provisional; Region: PRK10513 881621000418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000419 active site 881621000420 motif I; other site 881621000421 motif II; other site 881621000422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000423 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 881621000424 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 881621000425 active site 881621000426 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 881621000427 NlpC/P60 family; Region: NLPC_P60; pfam00877 881621000428 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 881621000429 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621000430 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000431 peptide binding site [polypeptide binding]; other site 881621000432 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 881621000433 SxDxEG motif; other site 881621000434 active site 881621000435 metal binding site [ion binding]; metal-binding site 881621000436 homopentamer interface [polypeptide binding]; other site 881621000437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 881621000438 Helix-turn-helix domain; Region: HTH_28; pfam13518 881621000439 putative transposase OrfB; Reviewed; Region: PHA02517 881621000440 HTH-like domain; Region: HTH_21; pfam13276 881621000441 Integrase core domain; Region: rve; pfam00665 881621000442 Integrase core domain; Region: rve_2; pfam13333 881621000443 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621000444 Collagen binding domain; Region: Collagen_bind; pfam05737 881621000445 Cna protein B-type domain; Region: Cna_B; pfam05738 881621000446 Cna protein B-type domain; Region: Cna_B; pfam05738 881621000447 Cna protein B-type domain; Region: Cna_B; pfam05738 881621000448 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621000449 DNA polymerase III subunit delta'; Validated; Region: PRK08058 881621000450 DNA polymerase III subunit delta'; Validated; Region: PRK08485 881621000451 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 881621000452 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 881621000453 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 881621000454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621000455 S-adenosylmethionine binding site [chemical binding]; other site 881621000456 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 881621000457 GIY-YIG motif/motif A; other site 881621000458 putative active site [active] 881621000459 putative metal binding site [ion binding]; other site 881621000460 Predicted methyltransferases [General function prediction only]; Region: COG0313 881621000461 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 881621000462 putative SAM binding site [chemical binding]; other site 881621000463 putative homodimer interface [polypeptide binding]; other site 881621000464 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 881621000465 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 881621000466 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000467 Uncharacterized conserved protein [Function unknown]; Region: COG5361 881621000468 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 881621000469 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 881621000470 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000471 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 881621000472 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 881621000473 active site 881621000474 HIGH motif; other site 881621000475 KMSKS motif; other site 881621000476 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 881621000477 tRNA binding surface [nucleotide binding]; other site 881621000478 anticodon binding site; other site 881621000479 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 881621000480 dimer interface [polypeptide binding]; other site 881621000481 putative tRNA-binding site [nucleotide binding]; other site 881621000482 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 881621000483 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621000485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 881621000486 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000488 dimer interface [polypeptide binding]; other site 881621000489 conserved gate region; other site 881621000490 putative PBP binding loops; other site 881621000491 ABC-ATPase subunit interface; other site 881621000492 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000494 dimer interface [polypeptide binding]; other site 881621000495 conserved gate region; other site 881621000496 putative PBP binding loops; other site 881621000497 ABC-ATPase subunit interface; other site 881621000498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621000499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621000500 alpha-glucosidase; Provisional; Region: PRK10426 881621000501 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621000502 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 881621000503 active site 881621000504 catalytic site [active] 881621000505 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621000506 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621000507 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 881621000508 trimer interface [polypeptide binding]; other site 881621000509 active site 881621000510 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 881621000511 catalytic site [active] 881621000512 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000513 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621000514 Ca binding site [ion binding]; other site 881621000515 active site 881621000516 catalytic site [active] 881621000517 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 881621000518 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 881621000519 active site 881621000520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 881621000521 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000522 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000523 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000524 G5 domain; Region: G5; pfam07501 881621000525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 881621000526 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 881621000527 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 881621000528 putative active site [active] 881621000529 putative metal binding site [ion binding]; other site 881621000530 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 881621000531 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 881621000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621000533 S-adenosylmethionine binding site [chemical binding]; other site 881621000534 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 881621000535 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 881621000536 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000537 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 881621000538 putative active site [active] 881621000539 YdjC motif; other site 881621000540 Mg binding site [ion binding]; other site 881621000541 putative homodimer interface [polypeptide binding]; other site 881621000542 pur operon repressor; Provisional; Region: PRK09213 881621000543 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 881621000544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621000545 active site 881621000546 HlyD family secretion protein; Region: HlyD_3; pfam13437 881621000547 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000548 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621000549 Walker A/P-loop; other site 881621000550 ATP binding site [chemical binding]; other site 881621000551 Q-loop/lid; other site 881621000552 ABC transporter signature motif; other site 881621000553 Walker B; other site 881621000554 D-loop; other site 881621000555 H-loop/switch region; other site 881621000556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621000557 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621000558 FtsX-like permease family; Region: FtsX; pfam02687 881621000559 regulatory protein SpoVG; Reviewed; Region: PRK13259 881621000560 regulatory protein SpoVG; Reviewed; Region: PRK13259 881621000561 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 881621000562 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 881621000563 Substrate binding site; other site 881621000564 Mg++ binding site; other site 881621000565 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 881621000566 active site 881621000567 substrate binding site [chemical binding]; other site 881621000568 CoA binding site [chemical binding]; other site 881621000569 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 881621000570 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 881621000571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621000572 active site 881621000573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000574 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621000575 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 881621000576 ActA Protein; Region: ActA; pfam05058 881621000577 ActA Protein; Region: ActA; pfam05058 881621000578 ActA Protein; Region: ActA; pfam05058 881621000579 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 881621000580 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621000581 active site 881621000582 metal binding site [ion binding]; metal-binding site 881621000583 hypothetical protein; Provisional; Region: PRK01119 881621000584 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 881621000585 A new structural DNA glycosylase; Region: AlkD_like; cl11434 881621000586 active site 881621000587 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 881621000588 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621000589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000590 NAD binding site [chemical binding]; other site 881621000591 dimer interface [polypeptide binding]; other site 881621000592 substrate binding site [chemical binding]; other site 881621000593 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 881621000594 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 881621000595 5S rRNA interface [nucleotide binding]; other site 881621000596 CTC domain interface [polypeptide binding]; other site 881621000597 L16 interface [polypeptide binding]; other site 881621000598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 881621000599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000600 Coenzyme A binding pocket [chemical binding]; other site 881621000601 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 881621000602 putative active site [active] 881621000603 catalytic residue [active] 881621000604 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 881621000605 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 881621000606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621000607 ATP binding site [chemical binding]; other site 881621000608 putative Mg++ binding site [ion binding]; other site 881621000609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621000610 nucleotide binding region [chemical binding]; other site 881621000611 ATP-binding site [chemical binding]; other site 881621000612 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 881621000613 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 881621000614 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 881621000615 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621000616 RNA binding surface [nucleotide binding]; other site 881621000617 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 881621000618 Septum formation initiator; Region: DivIC; pfam04977 881621000619 hypothetical protein; Provisional; Region: PRK08582 881621000620 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 881621000621 RNA binding site [nucleotide binding]; other site 881621000622 FtsH Extracellular; Region: FtsH_ext; pfam06480 881621000623 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 881621000624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000625 Walker A motif; other site 881621000626 ATP binding site [chemical binding]; other site 881621000627 Walker B motif; other site 881621000628 arginine finger; other site 881621000629 Peptidase family M41; Region: Peptidase_M41; pfam01434 881621000630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621000631 nucleotide binding site [chemical binding]; other site 881621000632 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 881621000633 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 881621000634 dimerization interface [polypeptide binding]; other site 881621000635 domain crossover interface; other site 881621000636 redox-dependent activation switch; other site 881621000637 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 881621000638 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 881621000639 dimer interface [polypeptide binding]; other site 881621000640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000641 catalytic residue [active] 881621000642 dihydropteroate synthase; Region: DHPS; TIGR01496 881621000643 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 881621000644 substrate binding pocket [chemical binding]; other site 881621000645 dimer interface [polypeptide binding]; other site 881621000646 inhibitor binding site; inhibition site 881621000647 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 881621000648 homooctamer interface [polypeptide binding]; other site 881621000649 active site 881621000650 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 881621000651 catalytic center binding site [active] 881621000652 ATP binding site [chemical binding]; other site 881621000653 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 881621000654 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 881621000655 FMN binding site [chemical binding]; other site 881621000656 active site 881621000657 catalytic residues [active] 881621000658 substrate binding site [chemical binding]; other site 881621000659 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 881621000660 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 881621000661 dimer interface [polypeptide binding]; other site 881621000662 putative anticodon binding site; other site 881621000663 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 881621000664 motif 1; other site 881621000665 active site 881621000666 motif 2; other site 881621000667 motif 3; other site 881621000668 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 881621000669 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 881621000670 UvrB/uvrC motif; Region: UVR; pfam02151 881621000671 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 881621000672 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 881621000673 ADP binding site [chemical binding]; other site 881621000674 phosphagen binding site; other site 881621000675 substrate specificity loop; other site 881621000676 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 881621000677 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000678 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000680 Walker A motif; other site 881621000681 ATP binding site [chemical binding]; other site 881621000682 Walker B motif; other site 881621000683 arginine finger; other site 881621000684 UvrB/uvrC motif; Region: UVR; pfam02151 881621000685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621000686 Walker A motif; other site 881621000687 ATP binding site [chemical binding]; other site 881621000688 Walker B motif; other site 881621000689 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 881621000690 DNA repair protein RadA; Provisional; Region: PRK11823 881621000691 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 881621000692 Walker A motif/ATP binding site; other site 881621000693 ATP binding site [chemical binding]; other site 881621000694 Walker B motif; other site 881621000695 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 881621000696 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 881621000697 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 881621000698 putative active site [active] 881621000699 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621000700 substrate binding site; other site 881621000701 dimer interface; other site 881621000702 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 881621000703 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000704 HIGH motif; other site 881621000705 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000706 active site 881621000707 KMSKS motif; other site 881621000708 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621000709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000710 putative DNA binding site [nucleotide binding]; other site 881621000711 putative Zn2+ binding site [ion binding]; other site 881621000712 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621000713 similar to pyruvate-formate lyase activating enzyme, partial 881621000714 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 881621000715 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621000716 putative active site cavity [active] 881621000717 similar to putative pyruvate formate-lyase 2,N-terminal part 881621000718 similar to putative pyruvate formate-lyase 2,C-terminal part 881621000719 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 881621000720 active site 881621000721 phosphorylation site [posttranslational modification] 881621000722 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 881621000723 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 881621000724 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621000725 active pocket/dimerization site; other site 881621000726 active site 881621000727 phosphorylation site [posttranslational modification] 881621000728 serine O-acetyltransferase; Region: cysE; TIGR01172 881621000729 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 881621000730 trimer interface [polypeptide binding]; other site 881621000731 active site 881621000732 substrate binding site [chemical binding]; other site 881621000733 CoA binding site [chemical binding]; other site 881621000734 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 881621000735 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000736 active site 881621000737 HIGH motif; other site 881621000738 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000739 KMSKS motif; other site 881621000740 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 881621000741 tRNA binding surface [nucleotide binding]; other site 881621000742 anticodon binding site; other site 881621000743 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 881621000744 active site 881621000745 metal binding site [ion binding]; metal-binding site 881621000746 dimerization interface [polypeptide binding]; other site 881621000747 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 881621000748 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 881621000749 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 881621000750 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 881621000751 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 881621000752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621000753 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 881621000754 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 881621000755 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 881621000756 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 881621000757 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 881621000758 putative homodimer interface [polypeptide binding]; other site 881621000759 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 881621000760 heterodimer interface [polypeptide binding]; other site 881621000761 homodimer interface [polypeptide binding]; other site 881621000762 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 881621000763 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 881621000764 23S rRNA interface [nucleotide binding]; other site 881621000765 L7/L12 interface [polypeptide binding]; other site 881621000766 putative thiostrepton binding site; other site 881621000767 L25 interface [polypeptide binding]; other site 881621000768 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 881621000769 mRNA/rRNA interface [nucleotide binding]; other site 881621000770 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 881621000771 23S rRNA interface [nucleotide binding]; other site 881621000772 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 881621000773 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 881621000774 core dimer interface [polypeptide binding]; other site 881621000775 peripheral dimer interface [polypeptide binding]; other site 881621000776 L10 interface [polypeptide binding]; other site 881621000777 L11 interface [polypeptide binding]; other site 881621000778 putative EF-Tu interaction site [polypeptide binding]; other site 881621000779 putative EF-G interaction site [polypeptide binding]; other site 881621000780 Methyltransferase domain; Region: Methyltransf_31; pfam13847 881621000781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621000782 S-adenosylmethionine binding site [chemical binding]; other site 881621000783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 881621000784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000786 DNA binding site [nucleotide binding] 881621000787 domain linker motif; other site 881621000788 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621000789 putative dimerization interface [polypeptide binding]; other site 881621000790 putative ligand binding site [chemical binding]; other site 881621000791 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621000792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621000793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000795 dimer interface [polypeptide binding]; other site 881621000796 conserved gate region; other site 881621000797 putative PBP binding loops; other site 881621000798 ABC-ATPase subunit interface; other site 881621000799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000801 dimer interface [polypeptide binding]; other site 881621000802 conserved gate region; other site 881621000803 putative PBP binding loops; other site 881621000804 ABC-ATPase subunit interface; other site 881621000805 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000806 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621000807 Ca binding site [ion binding]; other site 881621000808 active site 881621000809 catalytic site [active] 881621000810 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 881621000811 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 881621000812 active site 881621000813 homodimer interface [polypeptide binding]; other site 881621000814 catalytic site [active] 881621000815 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 881621000816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 881621000817 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 881621000818 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 881621000819 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 881621000820 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 881621000821 RPB10 interaction site [polypeptide binding]; other site 881621000822 RPB1 interaction site [polypeptide binding]; other site 881621000823 RPB11 interaction site [polypeptide binding]; other site 881621000824 RPB3 interaction site [polypeptide binding]; other site 881621000825 RPB12 interaction site [polypeptide binding]; other site 881621000826 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 881621000827 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 881621000828 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 881621000829 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 881621000830 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 881621000831 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000832 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 881621000833 G-loop; other site 881621000834 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000835 DNA binding site [nucleotide binding] 881621000836 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 881621000837 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 881621000838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621000839 active site 881621000840 motif I; other site 881621000841 motif II; other site 881621000842 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621000843 beta-galactosidase; Region: BGL; TIGR03356 881621000844 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 881621000845 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 881621000846 metal binding site [ion binding]; metal-binding site 881621000847 dimer interface [polypeptide binding]; other site 881621000848 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621000849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000850 putative DNA binding site [nucleotide binding]; other site 881621000851 putative Zn2+ binding site [ion binding]; other site 881621000852 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621000853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621000854 Zn binding site [ion binding]; other site 881621000855 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621000856 Zn binding site [ion binding]; other site 881621000857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621000858 catalytic core [active] 881621000859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621000861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000862 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 881621000863 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621000864 beta-galactosidase; Region: BGL; TIGR03356 881621000865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000866 Coenzyme A binding pocket [chemical binding]; other site 881621000867 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000868 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 881621000869 similar to unknown protein, C-terminal part 881621000870 similar to unknown protein, N-terminal part, start codon is missing 881621000871 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621000872 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621000873 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 881621000874 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 881621000875 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 881621000876 Walker A/P-loop; other site 881621000877 ATP binding site [chemical binding]; other site 881621000878 Q-loop/lid; other site 881621000879 ABC transporter signature motif; other site 881621000880 Walker B; other site 881621000881 D-loop; other site 881621000882 H-loop/switch region; other site 881621000883 TOBE domain; Region: TOBE; pfam03459 881621000884 ATP cone domain; Region: ATP-cone; pfam03477 881621000885 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 881621000886 Class III ribonucleotide reductase; Region: RNR_III; cd01675 881621000887 effector binding site; other site 881621000888 active site 881621000889 Zn binding site [ion binding]; other site 881621000890 glycine loop; other site 881621000891 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 881621000892 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 881621000893 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000894 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 881621000895 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621000896 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 881621000897 putative active site [active] 881621000898 catalytic triad [active] 881621000899 putative dimer interface [polypeptide binding]; other site 881621000900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621000901 dimer interface [polypeptide binding]; other site 881621000902 conserved gate region; other site 881621000903 ABC-ATPase subunit interface; other site 881621000904 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 881621000905 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 881621000906 Walker A/P-loop; other site 881621000907 ATP binding site [chemical binding]; other site 881621000908 Q-loop/lid; other site 881621000909 ABC transporter signature motif; other site 881621000910 Walker B; other site 881621000911 D-loop; other site 881621000912 H-loop/switch region; other site 881621000913 NIL domain; Region: NIL; pfam09383 881621000914 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 881621000915 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 881621000916 transaminase; Reviewed; Region: PRK08068 881621000917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621000918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000919 homodimer interface [polypeptide binding]; other site 881621000920 catalytic residue [active] 881621000921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621000922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621000923 active site 881621000924 phosphorylation site [posttranslational modification] 881621000925 intermolecular recognition site; other site 881621000926 dimerization interface [polypeptide binding]; other site 881621000927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621000928 DNA binding site [nucleotide binding] 881621000929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621000930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621000931 dimerization interface [polypeptide binding]; other site 881621000932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621000933 putative active site [active] 881621000934 heme pocket [chemical binding]; other site 881621000935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621000936 dimer interface [polypeptide binding]; other site 881621000937 phosphorylation site [posttranslational modification] 881621000938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000939 ATP binding site [chemical binding]; other site 881621000940 Mg2+ binding site [ion binding]; other site 881621000941 G-X-G motif; other site 881621000942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 881621000943 YycH protein; Region: YycH; pfam07435 881621000944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 881621000945 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 881621000946 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 881621000947 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 881621000948 protein binding site [polypeptide binding]; other site 881621000949 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621000950 beta-galactosidase; Region: BGL; TIGR03356 881621000951 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621000952 CAT RNA binding domain; Region: CAT_RBD; smart01061 881621000953 PRD domain; Region: PRD; pfam00874 881621000954 PRD domain; Region: PRD; pfam00874 881621000955 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621000956 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621000957 active site turn [active] 881621000958 phosphorylation site [posttranslational modification] 881621000959 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621000960 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621000961 HPr interaction site; other site 881621000962 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000963 active site 881621000964 phosphorylation site [posttranslational modification] 881621000965 Protein of unknown function (DUF998); Region: DUF998; pfam06197 881621000966 similar to transcriptional antiterminator (BglG family), C-terminal part 881621000967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621000968 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621000969 Walker A/P-loop; other site 881621000970 ATP binding site [chemical binding]; other site 881621000971 Q-loop/lid; other site 881621000972 ABC transporter signature motif; other site 881621000973 Walker B; other site 881621000974 D-loop; other site 881621000975 H-loop/switch region; other site 881621000976 similar to unknown proteins, C-terminal part 881621000977 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621000978 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621000979 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621000980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 881621000981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 881621000982 acyl-activating enzyme (AAE) consensus motif; other site 881621000983 acyl-activating enzyme (AAE) consensus motif; other site 881621000984 active site 881621000985 AMP binding site [chemical binding]; other site 881621000986 CoA binding site [chemical binding]; other site 881621000987 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 881621000988 L-aspartate oxidase; Provisional; Region: PRK06175 881621000989 putative oxidoreductase; Provisional; Region: PRK10206 881621000990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621000991 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 881621000992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621000993 active site 881621000994 phosphorylation site [posttranslational modification] 881621000995 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621000996 active site 881621000997 P-loop; other site 881621000998 phosphorylation site [posttranslational modification] 881621000999 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 881621001000 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621001001 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621001002 intersubunit interface [polypeptide binding]; other site 881621001003 active site 881621001004 zinc binding site [ion binding]; other site 881621001005 Na+ binding site [ion binding]; other site 881621001006 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001007 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 881621001008 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621001009 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621001010 conserved cys residue [active] 881621001011 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621001012 HTH domain; Region: HTH_11; pfam08279 881621001013 WYL domain; Region: WYL; pfam13280 881621001014 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 881621001015 nudix motif; other site 881621001016 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 881621001017 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 881621001018 PhnA protein; Region: PhnA; pfam03831 881621001019 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621001020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001021 DNA-binding site [nucleotide binding]; DNA binding site 881621001022 UTRA domain; Region: UTRA; pfam07702 881621001023 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621001024 beta-galactosidase; Region: BGL; TIGR03356 881621001025 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621001026 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621001027 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621001028 active site 881621001029 P-loop; other site 881621001030 phosphorylation site [posttranslational modification] 881621001031 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621001032 HTH domain; Region: HTH_11; pfam08279 881621001033 WYL domain; Region: WYL; pfam13280 881621001034 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 881621001035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621001036 non-specific DNA binding site [nucleotide binding]; other site 881621001037 salt bridge; other site 881621001038 sequence-specific DNA binding site [nucleotide binding]; other site 881621001039 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 881621001040 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 881621001041 tetrameric interface [polypeptide binding]; other site 881621001042 NAD binding site [chemical binding]; other site 881621001043 catalytic residues [active] 881621001044 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 881621001045 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621001046 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 881621001047 substrate binding site [chemical binding]; other site 881621001048 ATP binding site [chemical binding]; other site 881621001049 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 881621001050 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621001051 PYR/PP interface [polypeptide binding]; other site 881621001052 dimer interface [polypeptide binding]; other site 881621001053 TPP binding site [chemical binding]; other site 881621001054 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621001055 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 881621001056 TPP-binding site; other site 881621001057 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621001058 Uncharacterized conserved protein [Function unknown]; Region: COG5646 881621001059 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621001060 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621001061 ligand binding site [chemical binding]; other site 881621001062 active site 881621001063 UGI interface [polypeptide binding]; other site 881621001064 catalytic site [active] 881621001065 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 881621001066 hypothetical protein; Provisional; Region: PRK13665 881621001067 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 881621001068 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 881621001069 NodB motif; other site 881621001070 active site 881621001071 catalytic site [active] 881621001072 Zn binding site [ion binding]; other site 881621001073 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 881621001074 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 881621001075 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 881621001076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621001077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621001078 DNA binding residues [nucleotide binding] 881621001079 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001080 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 881621001081 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 881621001082 DXD motif; other site 881621001083 similar to unknown protein, C-terminal part 881621001084 similar to unknown protein, N-terminal part 881621001085 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621001086 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621001087 NlpC/P60 family; Region: NLPC_P60; pfam00877 881621001088 possibly truncated gene (N-terminal part) 881621001089 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 881621001090 pyrroline-5-carboxylate reductase; Region: PLN02688 881621001091 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001092 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001093 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001095 DNA-binding site [nucleotide binding]; DNA binding site 881621001096 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 881621001097 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621001098 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621001099 Walker A/P-loop; other site 881621001100 ATP binding site [chemical binding]; other site 881621001101 Q-loop/lid; other site 881621001102 ABC transporter signature motif; other site 881621001103 Walker B; other site 881621001104 D-loop; other site 881621001105 H-loop/switch region; other site 881621001106 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621001107 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621001108 FtsX-like permease family; Region: FtsX; pfam02687 881621001109 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 881621001110 putative hydrophobic ligand binding site [chemical binding]; other site 881621001111 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 881621001112 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 881621001113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621001114 putative metal binding site [ion binding]; other site 881621001115 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 881621001116 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621001117 trimer interface [polypeptide binding]; other site 881621001118 phosphoenolpyruvate synthase; Validated; Region: PRK06241 881621001119 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621001120 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 881621001121 similar to unknown protein, C-terminal part 881621001122 similar to unknown protein, N-terminal part 881621001123 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 881621001124 ZIP Zinc transporter; Region: Zip; pfam02535 881621001125 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 881621001126 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 881621001127 NodB motif; other site 881621001128 active site 881621001129 catalytic site [active] 881621001130 amidase; Provisional; Region: PRK06707 881621001131 Amidase; Region: Amidase; cl11426 881621001132 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 881621001133 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 881621001134 classical (c) SDRs; Region: SDR_c; cd05233 881621001135 NAD(P) binding site [chemical binding]; other site 881621001136 active site 881621001137 QueT transporter; Region: QueT; pfam06177 881621001138 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001139 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001140 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001141 Leucine rich repeat; Region: LRR_8; pfam13855 881621001142 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001143 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001144 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001145 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001146 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001147 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001148 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001149 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001150 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001151 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001152 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621001153 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621001154 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621001155 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001156 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001157 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001158 Leucine-rich repeats; other site 881621001159 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001160 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001161 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001162 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621001163 SH3-like domain; Region: SH3_8; pfam13457 881621001164 SH3-like domain; Region: SH3_8; pfam13457 881621001165 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001166 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001167 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001168 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001169 Leucine rich repeat; Region: LRR_8; pfam13855 881621001170 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001171 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001172 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621001173 SH3-like domain; Region: SH3_8; pfam13457 881621001174 SH3-like domain; Region: SH3_8; pfam13457 881621001175 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 881621001176 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 881621001177 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 881621001178 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 881621001179 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621001180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 881621001181 Transcriptional regulator [Transcription]; Region: LytR; COG1316 881621001182 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 881621001183 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 881621001184 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 881621001185 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 881621001186 Protein of unknown function DUF58; Region: DUF58; pfam01882 881621001187 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621001188 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 881621001189 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 881621001190 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 881621001191 Na binding site [ion binding]; other site 881621001192 Uncharacterized conserved protein [Function unknown]; Region: COG3535 881621001193 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 881621001194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621001195 nucleotide binding site [chemical binding]; other site 881621001196 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 881621001197 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 881621001198 similar to unknown protein, N-terminal part 881621001199 similar to unknown protein, central part 881621001200 similar to unknown protein, partial 881621001201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621001202 Zn2+ binding site [ion binding]; other site 881621001203 Mg2+ binding site [ion binding]; other site 881621001204 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 881621001205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621001206 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 881621001207 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 881621001208 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 881621001209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621001210 FeS/SAM binding site; other site 881621001211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 881621001212 similar to unknown protein, C-terminal part 881621001213 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 881621001214 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 881621001215 putative active site [active] 881621001216 putative nucleic acid binding site [nucleotide binding]; other site 881621001217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621001218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621001219 non-specific DNA binding site [nucleotide binding]; other site 881621001220 salt bridge; other site 881621001221 sequence-specific DNA binding site [nucleotide binding]; other site 881621001222 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 881621001223 putative FMN binding site [chemical binding]; other site 881621001224 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 881621001225 oxidoreductase; Provisional; Region: PRK07985 881621001226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001227 NAD(P) binding site [chemical binding]; other site 881621001228 active site 881621001229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 881621001230 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 881621001231 similar to unknown protein, partial 881621001232 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 881621001233 nudix motif; other site 881621001234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621001236 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621001237 putative dimerization interface [polypeptide binding]; other site 881621001238 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 881621001239 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 881621001240 active site 881621001241 FMN binding site [chemical binding]; other site 881621001242 substrate binding site [chemical binding]; other site 881621001243 putative catalytic residue [active] 881621001244 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 881621001245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 881621001246 NAD binding site [chemical binding]; other site 881621001247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621001248 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621001249 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621001250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621001251 shikimate binding site; other site 881621001252 NAD(P) binding site [chemical binding]; other site 881621001253 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 881621001254 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 881621001255 active site 881621001256 catalytic residue [active] 881621001257 dimer interface [polypeptide binding]; other site 881621001258 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621001260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621001261 dimerization interface [polypeptide binding]; other site 881621001262 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621001263 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 881621001264 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 881621001265 active site 881621001266 catalytic triad [active] 881621001267 oxyanion hole [active] 881621001268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 881621001269 similar to sugar transferase, fragment 881621001270 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 881621001271 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001272 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001273 substrate binding site [chemical binding]; other site 881621001274 hexamer interface [polypeptide binding]; other site 881621001275 metal binding site [ion binding]; metal-binding site 881621001276 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 881621001277 catalytic residue [active] 881621001278 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001279 PRD domain; Region: PRD; pfam00874 881621001280 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001281 active site 881621001282 P-loop; other site 881621001283 phosphorylation site [posttranslational modification] 881621001284 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001285 active site 881621001286 phosphorylation site [posttranslational modification] 881621001287 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 881621001288 putative active site [active] 881621001289 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001290 active site 881621001291 phosphorylation site [posttranslational modification] 881621001292 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001293 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001294 substrate binding site [chemical binding]; other site 881621001295 hexamer interface [polypeptide binding]; other site 881621001296 metal binding site [ion binding]; metal-binding site 881621001297 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621001298 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621001299 putative NAD(P) binding site [chemical binding]; other site 881621001300 catalytic Zn binding site [ion binding]; other site 881621001301 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621001302 active site 881621001303 P-loop; other site 881621001304 phosphorylation site [posttranslational modification] 881621001305 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 881621001306 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621001307 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 881621001308 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 881621001309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621001310 active site 881621001311 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 881621001312 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 881621001313 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 881621001314 catalytic triad [active] 881621001315 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 881621001316 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621001317 MarR family; Region: MarR_2; pfam12802 881621001318 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621001320 Ligand Binding Site [chemical binding]; other site 881621001321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001322 catalytic core [active] 881621001323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001324 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621001325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621001326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621001327 Walker A/P-loop; other site 881621001328 ATP binding site [chemical binding]; other site 881621001329 Q-loop/lid; other site 881621001330 ABC transporter signature motif; other site 881621001331 Walker B; other site 881621001332 D-loop; other site 881621001333 H-loop/switch region; other site 881621001334 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 881621001335 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 881621001336 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 881621001337 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 881621001338 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 881621001339 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 881621001340 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 881621001341 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 881621001342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621001343 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 881621001344 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 881621001345 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 881621001346 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621001347 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621001348 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 881621001349 dimer interface [polypeptide binding]; other site 881621001350 conserved gate region; other site 881621001351 putative PBP binding loops; other site 881621001352 ABC-ATPase subunit interface; other site 881621001353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621001354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621001355 dimer interface [polypeptide binding]; other site 881621001356 conserved gate region; other site 881621001357 putative PBP binding loops; other site 881621001358 ABC-ATPase subunit interface; other site 881621001359 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 881621001360 putative active site [active] 881621001361 catalytic site [active] 881621001362 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001363 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621001364 nucleotide binding site [chemical binding]; other site 881621001365 Uncharacterized conserved protein [Function unknown]; Region: COG3538 881621001366 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 881621001367 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621001368 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 881621001369 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621001370 putative active site [active] 881621001371 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621001372 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 881621001373 Predicted membrane protein [Function unknown]; Region: COG3759 881621001374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621001376 putative substrate translocation pore; other site 881621001377 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 881621001378 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 881621001380 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001381 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001382 NAD binding site [chemical binding]; other site 881621001383 sugar binding site [chemical binding]; other site 881621001384 divalent metal binding site [ion binding]; other site 881621001385 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001386 dimer interface [polypeptide binding]; other site 881621001387 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621001388 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621001389 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621001390 putative active site [active] 881621001391 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 881621001392 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 881621001393 Sulfate transporter family; Region: Sulfate_transp; pfam00916 881621001394 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621001395 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001396 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 881621001397 DNA binding residues [nucleotide binding] 881621001398 dimer interface [polypeptide binding]; other site 881621001399 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 881621001400 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 881621001401 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 881621001402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 881621001403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621001404 S-adenosylmethionine binding site [chemical binding]; other site 881621001405 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 881621001406 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 881621001407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001409 DNA binding site [nucleotide binding] 881621001410 domain linker motif; other site 881621001411 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621001412 putative dimerization interface [polypeptide binding]; other site 881621001413 putative ligand binding site [chemical binding]; other site 881621001414 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001415 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001416 NAD binding site [chemical binding]; other site 881621001417 sugar binding site [chemical binding]; other site 881621001418 divalent metal binding site [ion binding]; other site 881621001419 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001420 dimer interface [polypeptide binding]; other site 881621001421 allantoate amidohydrolase; Reviewed; Region: PRK09290 881621001422 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 881621001423 active site 881621001424 metal binding site [ion binding]; metal-binding site 881621001425 dimer interface [polypeptide binding]; other site 881621001426 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621001427 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 881621001428 metal binding site [ion binding]; metal-binding site 881621001429 putative dimer interface [polypeptide binding]; other site 881621001430 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 881621001431 Beta-lactamase; Region: Beta-lactamase; pfam00144 881621001432 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 881621001433 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621001434 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621001435 intersubunit interface [polypeptide binding]; other site 881621001436 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 881621001437 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 881621001438 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 881621001439 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 881621001440 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 881621001441 Glucitol operon activator protein (GutM); Region: GutM; cl01890 881621001442 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 881621001443 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 881621001444 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621001445 Homeodomain-like domain; Region: HTH_23; pfam13384 881621001446 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621001447 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621001448 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001449 Substrate binding site [chemical binding]; other site 881621001450 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001451 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001452 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001453 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001454 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001455 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001456 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001457 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001458 FOG: CBS domain [General function prediction only]; Region: COG0517 881621001459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 881621001460 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 881621001461 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 881621001462 dimer interface [polypeptide binding]; other site 881621001463 active site 881621001464 metal binding site [ion binding]; metal-binding site 881621001465 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 881621001466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001467 putative substrate translocation pore; other site 881621001468 POT family; Region: PTR2; cl17359 881621001469 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001470 catalytic core [active] 881621001471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001472 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001473 catalytic core [active] 881621001474 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001475 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 881621001476 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 881621001477 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 881621001478 Cl binding site [ion binding]; other site 881621001479 oligomer interface [polypeptide binding]; other site 881621001480 glutamate dehydrogenase; Provisional; Region: PRK09414 881621001481 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 881621001482 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 881621001483 NAD(P) binding site [chemical binding]; other site 881621001484 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 881621001485 metal binding site [ion binding]; metal-binding site 881621001486 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 881621001487 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 881621001488 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 881621001489 substrate binding site [chemical binding]; other site 881621001490 glutamase interaction surface [polypeptide binding]; other site 881621001491 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 881621001492 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 881621001493 catalytic residues [active] 881621001494 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 881621001495 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 881621001496 putative active site [active] 881621001497 oxyanion strand; other site 881621001498 catalytic triad [active] 881621001499 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 881621001500 4-fold oligomerization interface [polypeptide binding]; other site 881621001501 putative active site pocket [active] 881621001502 metal binding residues [ion binding]; metal-binding site 881621001503 3-fold/trimer interface [polypeptide binding]; other site 881621001504 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 881621001505 histidinol dehydrogenase; Region: hisD; TIGR00069 881621001506 NAD binding site [chemical binding]; other site 881621001507 dimerization interface [polypeptide binding]; other site 881621001508 product binding site; other site 881621001509 substrate binding site [chemical binding]; other site 881621001510 zinc binding site [ion binding]; other site 881621001511 catalytic residues [active] 881621001512 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 881621001513 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 881621001514 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 881621001515 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 881621001516 dimer interface [polypeptide binding]; other site 881621001517 motif 1; other site 881621001518 active site 881621001519 motif 2; other site 881621001520 histidinol-phosphatase; Reviewed; Region: PRK08123 881621001521 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 881621001522 active site 881621001523 dimer interface [polypeptide binding]; other site 881621001524 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 881621001525 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621001526 DNA binding site [nucleotide binding] 881621001527 active site 881621001528 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 881621001529 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621001530 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621001531 beta-galactosidase; Region: BGL; TIGR03356 881621001532 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621001533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001534 DNA-binding site [nucleotide binding]; DNA binding site 881621001535 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 881621001536 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 881621001538 xylose isomerase; Provisional; Region: PRK05474 881621001539 xylose isomerase; Region: xylose_isom_A; TIGR02630 881621001540 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 881621001541 N- and C-terminal domain interface [polypeptide binding]; other site 881621001542 D-xylulose kinase; Region: XylB; TIGR01312 881621001543 active site 881621001544 MgATP binding site [chemical binding]; other site 881621001545 catalytic site [active] 881621001546 metal binding site [ion binding]; metal-binding site 881621001547 xylulose binding site [chemical binding]; other site 881621001548 homodimer interface [polypeptide binding]; other site 881621001549 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 881621001550 Uncharacterized conserved protein [Function unknown]; Region: COG2966 881621001551 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 881621001552 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 881621001553 Predicted esterase [General function prediction only]; Region: COG0400 881621001554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 881621001555 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 881621001556 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 881621001557 putative RNA binding site [nucleotide binding]; other site 881621001558 S-adenosylmethionine binding site [chemical binding]; other site 881621001559 Methyltransferase domain; Region: Methyltransf_26; pfam13659 881621001560 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 881621001561 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621001562 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621001563 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621001564 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 881621001565 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621001566 NlpC/P60 family; Region: NLPC_P60; pfam00877 881621001567 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 881621001568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621001569 ATP binding site [chemical binding]; other site 881621001570 putative Mg++ binding site [ion binding]; other site 881621001571 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 881621001572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 881621001573 nucleotide binding region [chemical binding]; other site 881621001574 ATP-binding site [chemical binding]; other site 881621001575 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621001576 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621001577 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621001578 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001579 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001580 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 881621001581 DNA photolyase; Region: DNA_photolyase; pfam00875 881621001582 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 881621001583 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 881621001584 DAK2 domain; Region: Dak2; pfam02734 881621001585 EDD domain protein, DegV family; Region: DegV; TIGR00762 881621001586 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 881621001587 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 881621001588 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 881621001589 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 881621001590 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 881621001591 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 881621001592 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621001593 homodimer interface [polypeptide binding]; other site 881621001594 substrate-cofactor binding pocket; other site 881621001595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621001596 catalytic residue [active] 881621001597 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 881621001598 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001599 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621001600 ligand binding site [chemical binding]; other site 881621001601 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621001602 BioY family; Region: BioY; pfam02632 881621001603 Predicted transcriptional regulators [Transcription]; Region: COG1695 881621001604 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 881621001605 Predicted membrane protein [Function unknown]; Region: COG4709 881621001606 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621001607 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001608 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001609 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621001610 weakly similar to transcription regulator,C-terminal part 881621001611 Tic20-like protein; Region: Tic20; pfam09685 881621001612 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 881621001613 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621001614 MarR family; Region: MarR_2; pfam12802 881621001615 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621001616 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001617 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621001618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621001619 Walker A/P-loop; other site 881621001620 ATP binding site [chemical binding]; other site 881621001621 Q-loop/lid; other site 881621001622 ABC transporter signature motif; other site 881621001623 Walker B; other site 881621001624 D-loop; other site 881621001625 H-loop/switch region; other site 881621001626 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621001628 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 881621001629 Walker A/P-loop; other site 881621001630 ATP binding site [chemical binding]; other site 881621001631 Q-loop/lid; other site 881621001632 ABC transporter signature motif; other site 881621001633 Walker B; other site 881621001634 D-loop; other site 881621001635 H-loop/switch region; other site 881621001636 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621001637 active site residue [active] 881621001638 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001639 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001640 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001641 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 881621001642 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 881621001643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621001644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621001645 putative DNA binding site [nucleotide binding]; other site 881621001646 putative Zn2+ binding site [ion binding]; other site 881621001647 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 881621001648 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 881621001649 putative NAD(P) binding site [chemical binding]; other site 881621001650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 881621001651 similar to glycerophosphodiester phosphodiesterase,partial 881621001652 Catalytic domain of Protein Kinases; Region: PKc; cd00180 881621001653 active site 881621001654 ATP binding site [chemical binding]; other site 881621001655 substrate binding site [chemical binding]; other site 881621001656 activation loop (A-loop); other site 881621001657 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 881621001658 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 881621001659 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621001660 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621001661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621001662 Coenzyme A binding pocket [chemical binding]; other site 881621001663 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 881621001664 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 881621001665 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001666 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621001667 DNA binding residues [nucleotide binding] 881621001668 putative dimer interface [polypeptide binding]; other site 881621001669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 881621001670 active site 881621001671 catalytic triad [active] 881621001672 oxyanion hole [active] 881621001673 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621001674 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 881621001675 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621001676 active site turn [active] 881621001677 phosphorylation site [posttranslational modification] 881621001678 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 881621001679 HPr interaction site; other site 881621001680 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001681 active site 881621001682 phosphorylation site [posttranslational modification] 881621001683 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621001684 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621001685 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621001686 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621001687 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 881621001688 Metal-binding active site; metal-binding site 881621001689 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001690 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 881621001691 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621001692 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 881621001693 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001694 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 881621001695 ATP synthase subunit C; Region: ATP-synt_C; cl00466 881621001696 weakly similar to ATP synthase delta chain,N-terminal part 881621001697 weakly similar to ATP synthase delta chain,C-terminal part 881621001698 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 881621001699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 881621001700 Walker A motif; other site 881621001701 ATP binding site [chemical binding]; other site 881621001702 Walker B motif; other site 881621001703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621001704 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 881621001705 core domain interface [polypeptide binding]; other site 881621001706 delta subunit interface [polypeptide binding]; other site 881621001707 epsilon subunit interface [polypeptide binding]; other site 881621001708 Similar to ATP synthase beta chain 881621001709 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 881621001710 gamma subunit interface [polypeptide binding]; other site 881621001711 epsilon subunit interface [polypeptide binding]; other site 881621001712 LBP interface [polypeptide binding]; other site 881621001713 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001714 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001715 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001716 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001717 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001718 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001719 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001720 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001721 PRD domain; Region: PRD; pfam00874 881621001722 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001723 active site 881621001724 P-loop; other site 881621001725 phosphorylation site [posttranslational modification] 881621001726 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001727 active site 881621001728 phosphorylation site [posttranslational modification] 881621001729 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001730 active site 881621001731 phosphorylation site [posttranslational modification] 881621001732 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 881621001733 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621001734 active site 881621001735 P-loop; other site 881621001736 phosphorylation site [posttranslational modification] 881621001737 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 881621001738 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 881621001739 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 881621001740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001741 motif II; other site 881621001742 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621001743 Transcriptional regulator; Region: Rrf2; pfam02082 881621001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621001745 S-adenosylmethionine binding site [chemical binding]; other site 881621001746 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 881621001747 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621001748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621001749 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621001750 active site 881621001751 catalytic tetrad [active] 881621001752 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 881621001753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001755 motif II; other site 881621001756 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 881621001757 catalytic residue [active] 881621001758 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621001759 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 881621001760 Sulfatase; Region: Sulfatase; pfam00884 881621001761 amino acid transporter; Region: 2A0306; TIGR00909 881621001762 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 881621001763 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 881621001764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 881621001765 putative metal binding site [ion binding]; other site 881621001766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621001767 active site 881621001768 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621001769 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 881621001770 Cl binding site [ion binding]; other site 881621001771 oligomer interface [polypeptide binding]; other site 881621001772 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001774 DNA-binding site [nucleotide binding]; DNA binding site 881621001775 Predicted membrane protein [Function unknown]; Region: COG1511 881621001776 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621001777 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 881621001778 putative YPXnL-motif binding site; other site 881621001779 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 881621001780 Transcriptional regulators [Transcription]; Region: FadR; COG2186 881621001781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001782 DNA-binding site [nucleotide binding]; DNA binding site 881621001783 FCD domain; Region: FCD; pfam07729 881621001784 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 881621001785 Predicted integral membrane protein [Function unknown]; Region: COG5523 881621001786 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621001787 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 881621001788 active site 881621001789 metal binding site [ion binding]; metal-binding site 881621001790 Predicted membrane protein [Function unknown]; Region: COG2322 881621001791 Luteovirus RNA polymerase P1-P2/replicase; Region: Luteo_P1-P2; pfam08467 881621001792 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 881621001793 dimer interface [polypeptide binding]; other site 881621001794 substrate binding site [chemical binding]; other site 881621001795 ATP binding site [chemical binding]; other site 881621001796 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621001797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001798 active site 881621001799 motif I; other site 881621001800 motif II; other site 881621001801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621001802 maltose O-acetyltransferase; Provisional; Region: PRK10092 881621001803 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621001804 active site 881621001805 substrate binding site [chemical binding]; other site 881621001806 trimer interface [polypeptide binding]; other site 881621001807 CoA binding site [chemical binding]; other site 881621001808 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 881621001809 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621001810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621001811 Walker A/P-loop; other site 881621001812 ATP binding site [chemical binding]; other site 881621001813 Q-loop/lid; other site 881621001814 ABC transporter signature motif; other site 881621001815 Walker B; other site 881621001816 D-loop; other site 881621001817 H-loop/switch region; other site 881621001818 inner membrane transport permease; Provisional; Region: PRK15066 881621001819 Predicted membrane protein [Function unknown]; Region: COG3152 881621001820 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 881621001821 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 881621001822 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 881621001823 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 881621001824 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 881621001825 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 881621001826 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 881621001827 FHIPEP family; Region: FHIPEP; pfam00771 881621001828 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 881621001829 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 881621001830 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 881621001831 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 881621001832 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 881621001833 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 881621001834 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 881621001835 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 881621001836 flagellar motor protein MotA; Validated; Region: PRK08124 881621001837 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 881621001838 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 881621001839 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 881621001840 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 881621001841 ligand binding site [chemical binding]; other site 881621001842 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 881621001843 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 881621001844 putative metal binding site; other site 881621001845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621001846 binding surface 881621001847 TPR motif; other site 881621001848 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 881621001849 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 881621001850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621001851 active site 881621001852 phosphorylation site [posttranslational modification] 881621001853 intermolecular recognition site; other site 881621001854 dimerization interface [polypeptide binding]; other site 881621001855 flagellin; Provisional; Region: PRK12805 881621001856 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001857 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 881621001858 Response regulator receiver domain; Region: Response_reg; pfam00072 881621001859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621001860 active site 881621001861 phosphorylation site [posttranslational modification] 881621001862 intermolecular recognition site; other site 881621001863 dimerization interface [polypeptide binding]; other site 881621001864 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 881621001865 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 881621001866 putative binding surface; other site 881621001867 active site 881621001868 P2 response regulator binding domain; Region: P2; pfam07194 881621001869 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 881621001870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621001871 ATP binding site [chemical binding]; other site 881621001872 Mg2+ binding site [ion binding]; other site 881621001873 G-X-G motif; other site 881621001874 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 881621001875 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001876 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 881621001877 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 881621001878 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 881621001879 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 881621001880 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 881621001881 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 881621001882 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 881621001883 flagellar motor switch protein; Validated; Region: PRK06789 881621001884 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 881621001885 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 881621001886 flagellar motor switch protein; Reviewed; Region: PRK06782 881621001887 CheC-like family; Region: CheC; pfam04509 881621001888 CheC-like family; Region: CheC; pfam04509 881621001889 Chemotaxis phosphatase CheX; Region: CheX; cl15816 881621001890 CheC-like family; Region: CheC; pfam04509 881621001891 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 881621001892 Protein of unknown function (DUF327); Region: DUF327; pfam03885 881621001893 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 881621001894 glycoprotein BALF4; Provisional; Region: PHA03231 881621001895 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 881621001896 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 881621001897 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001898 flagellar capping protein; Validated; Region: fliD; PRK06798 881621001899 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 881621001900 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 881621001901 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 881621001902 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 881621001903 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 881621001904 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 881621001905 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 881621001906 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 881621001907 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 881621001908 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 881621001909 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 881621001910 FliG C-terminal domain; Region: FliG_C; pfam01706 881621001911 flagellar assembly protein H; Validated; Region: fliH; PRK06800 881621001912 Flagellar assembly protein FliH; Region: FliH; pfam02108 881621001913 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 881621001914 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 881621001915 Walker A motif; other site 881621001916 ATP binding site [chemical binding]; other site 881621001917 Walker B motif; other site 881621001918 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 881621001919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 881621001920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 881621001921 catalytic residue [active] 881621001922 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621001923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001924 Soluble P-type ATPase [General function prediction only]; Region: COG4087 881621001925 Predicted transcriptional regulators [Transcription]; Region: COG1695 881621001926 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 881621001927 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 881621001928 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621001929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621001930 Walker A/P-loop; other site 881621001931 ATP binding site [chemical binding]; other site 881621001932 Q-loop/lid; other site 881621001933 ABC transporter signature motif; other site 881621001934 Walker B; other site 881621001935 D-loop; other site 881621001936 H-loop/switch region; other site 881621001937 ABC-2 type transporter; Region: ABC2_membrane; cl17235 881621001938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 881621001939 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 881621001940 pyruvate oxidase; Provisional; Region: PRK08611 881621001941 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 881621001942 PYR/PP interface [polypeptide binding]; other site 881621001943 dimer interface [polypeptide binding]; other site 881621001944 tetramer interface [polypeptide binding]; other site 881621001945 TPP binding site [chemical binding]; other site 881621001946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621001947 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 881621001948 TPP-binding site [chemical binding]; other site 881621001949 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 881621001950 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 881621001951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621001952 dimerization interface [polypeptide binding]; other site 881621001953 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 881621001954 dimer interface [polypeptide binding]; other site 881621001955 putative CheW interface [polypeptide binding]; other site 881621001956 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 881621001957 putative active site [active] 881621001958 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 881621001959 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 881621001960 glutaminase active site [active] 881621001961 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621001962 dimer interface [polypeptide binding]; other site 881621001963 active site 881621001964 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621001965 dimer interface [polypeptide binding]; other site 881621001966 active site 881621001967 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 881621001968 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621001969 active site 881621001970 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 881621001971 GIY-YIG motif/motif A; other site 881621001972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001974 DNA binding site [nucleotide binding] 881621001975 domain linker motif; other site 881621001976 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621001977 ligand binding site [chemical binding]; other site 881621001978 dimerization interface [polypeptide binding]; other site 881621001979 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001980 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621001981 substrate binding site [chemical binding]; other site 881621001982 hexamer interface [polypeptide binding]; other site 881621001983 metal binding site [ion binding]; metal-binding site 881621001984 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 881621001985 Protein of unknown function (DUF556); Region: DUF556; cl00822 881621001986 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621001987 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621001988 active site turn [active] 881621001989 phosphorylation site [posttranslational modification] 881621001990 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621001991 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 881621001992 HPr interaction site; other site 881621001993 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001994 active site 881621001995 phosphorylation site [posttranslational modification] 881621001996 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621001997 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621001998 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001999 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621002000 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621002001 ligand binding site [chemical binding]; other site 881621002002 flexible hinge region; other site 881621002003 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621002004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002005 DNA-binding site [nucleotide binding]; DNA binding site 881621002006 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 881621002007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621002008 Walker A/P-loop; other site 881621002009 ATP binding site [chemical binding]; other site 881621002010 Q-loop/lid; other site 881621002011 ABC transporter signature motif; other site 881621002012 Walker B; other site 881621002013 D-loop; other site 881621002014 H-loop/switch region; other site 881621002015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621002016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621002017 Walker A/P-loop; other site 881621002018 ATP binding site [chemical binding]; other site 881621002019 Q-loop/lid; other site 881621002020 ABC transporter signature motif; other site 881621002021 Walker B; other site 881621002022 D-loop; other site 881621002023 H-loop/switch region; other site 881621002024 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 881621002025 FtsX-like permease family; Region: FtsX; pfam02687 881621002026 AAA domain; Region: AAA_17; pfam13207 881621002027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621002028 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621002029 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621002030 ligand binding site [chemical binding]; other site 881621002031 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 881621002032 putative switch regulator; other site 881621002033 non-specific DNA interactions [nucleotide binding]; other site 881621002034 DNA binding site [nucleotide binding] 881621002035 sequence specific DNA binding site [nucleotide binding]; other site 881621002036 putative cAMP binding site [chemical binding]; other site 881621002037 SnoaL-like domain; Region: SnoaL_4; pfam13577 881621002038 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621002039 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 881621002040 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621002041 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 881621002042 active site 881621002043 Similar to beta-glucoside-specific PTS system enzyme IIABC (N terminal part) 881621002044 Similar to beta-glucoside-specific PTS system enzyme IIABC, central part 881621002045 Similar to beta-glucoside-specific PTS system enzyme IIABC, c-terminal part 881621002046 similar to putative purine nucleoside phosphorylase, N-terminal part 881621002047 similar to putative purine nucleoside phosphorylase, central part 881621002048 similar to putative purine nucleoside phosphorylase, c-terminal part 881621002049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621002050 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 881621002051 active site 881621002052 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621002053 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621002054 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621002055 Zn binding site [ion binding]; other site 881621002056 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621002057 Zn binding site [ion binding]; other site 881621002058 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621002059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002060 Zn binding site [ion binding]; other site 881621002061 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621002062 Zn binding site [ion binding]; other site 881621002063 Predicted esterase [General function prediction only]; Region: COG0400 881621002064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 881621002065 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 881621002066 GTPases [General function prediction only]; Region: HflX; COG2262 881621002067 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 881621002068 HflX GTPase family; Region: HflX; cd01878 881621002069 G1 box; other site 881621002070 GTP/Mg2+ binding site [chemical binding]; other site 881621002071 Switch I region; other site 881621002072 G2 box; other site 881621002073 G3 box; other site 881621002074 Switch II region; other site 881621002075 G4 box; other site 881621002076 G5 box; other site 881621002077 phosphodiesterase YaeI; Provisional; Region: PRK11340 881621002078 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621002079 putative active site [active] 881621002080 putative metal binding site [ion binding]; other site 881621002081 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621002082 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 881621002083 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621002084 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621002085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002086 DNA-binding site [nucleotide binding]; DNA binding site 881621002087 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 881621002088 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 881621002089 NAD(P) binding site [chemical binding]; other site 881621002090 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 881621002091 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 881621002092 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621002093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621002094 nucleotide binding site [chemical binding]; other site 881621002095 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 881621002096 Predicted membrane protein [Function unknown]; Region: COG4811 881621002097 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 881621002098 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 881621002099 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 881621002100 active site 881621002101 phosphorylation site [posttranslational modification] 881621002102 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621002103 active pocket/dimerization site; other site 881621002104 active site 881621002105 phosphorylation site [posttranslational modification] 881621002106 Helix-turn-helix domain; Region: HTH_20; pfam12840 881621002107 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621002108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002109 Walker A motif; other site 881621002110 ATP binding site [chemical binding]; other site 881621002111 Walker B motif; other site 881621002112 arginine finger; other site 881621002113 Transcriptional antiterminator [Transcription]; Region: COG3933 881621002114 PRD domain; Region: PRD; pfam00874 881621002115 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621002116 active pocket/dimerization site; other site 881621002117 active site 881621002118 phosphorylation site [posttranslational modification] 881621002119 PRD domain; Region: PRD; pfam00874 881621002120 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 881621002121 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 881621002122 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 881621002123 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 881621002124 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 881621002125 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 881621002126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 881621002127 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 881621002128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 881621002129 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 881621002130 putative deacylase active site [active] 881621002131 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621002132 Protein of unknown function (DUF554); Region: DUF554; pfam04474 881621002133 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621002134 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621002135 NAD binding site [chemical binding]; other site 881621002136 putative active site [active] 881621002137 substrate binding site [chemical binding]; other site 881621002138 Predicted permeases [General function prediction only]; Region: RarD; COG2962 881621002139 EamA-like transporter family; Region: EamA; pfam00892 881621002140 Uncharacterized conserved protein [Function unknown]; Region: COG2353 881621002141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621002142 MarR family; Region: MarR_2; pfam12802 881621002143 lysine transporter; Provisional; Region: PRK10836 881621002144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621002145 PAS domain; Region: PAS_9; pfam13426 881621002146 putative active site [active] 881621002147 heme pocket [chemical binding]; other site 881621002148 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 881621002150 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621002151 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 881621002152 synthetase active site [active] 881621002153 NTP binding site [chemical binding]; other site 881621002154 metal binding site [ion binding]; metal-binding site 881621002155 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621002156 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 881621002157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621002158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621002159 non-specific DNA binding site [nucleotide binding]; other site 881621002160 salt bridge; other site 881621002161 sequence-specific DNA binding site [nucleotide binding]; other site 881621002162 Cupin domain; Region: Cupin_2; pfam07883 881621002163 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 881621002164 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 881621002165 Walker A/P-loop; other site 881621002166 ATP binding site [chemical binding]; other site 881621002167 Q-loop/lid; other site 881621002168 ABC transporter signature motif; other site 881621002169 Walker B; other site 881621002170 D-loop; other site 881621002171 H-loop/switch region; other site 881621002172 TOBE domain; Region: TOBE_2; pfam08402 881621002173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621002174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002175 putative PBP binding loops; other site 881621002176 ABC-ATPase subunit interface; other site 881621002177 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 881621002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002179 dimer interface [polypeptide binding]; other site 881621002180 conserved gate region; other site 881621002181 putative PBP binding loops; other site 881621002182 ABC-ATPase subunit interface; other site 881621002183 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 881621002184 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 881621002185 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621002186 similar to transcription regulator (C-terminal part) 881621002187 Similar to transcription regulator (N-terminal part) 881621002188 similar to unknown protein, C-terminal part 881621002189 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 881621002190 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 881621002191 active site 881621002192 zinc binding site [ion binding]; other site 881621002193 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 881621002194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621002195 Zn2+ binding site [ion binding]; other site 881621002196 Mg2+ binding site [ion binding]; other site 881621002197 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621002198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621002199 nucleotide binding site [chemical binding]; other site 881621002200 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621002201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621002202 active site 881621002203 phosphorylation site [posttranslational modification] 881621002204 intermolecular recognition site; other site 881621002205 dimerization interface [polypeptide binding]; other site 881621002206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621002207 DNA binding site [nucleotide binding] 881621002208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621002209 dimerization interface [polypeptide binding]; other site 881621002210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621002211 dimer interface [polypeptide binding]; other site 881621002212 phosphorylation site [posttranslational modification] 881621002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002214 ATP binding site [chemical binding]; other site 881621002215 Mg2+ binding site [ion binding]; other site 881621002216 G-X-G motif; other site 881621002217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621002218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621002219 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621002220 Walker A/P-loop; other site 881621002221 ATP binding site [chemical binding]; other site 881621002222 Q-loop/lid; other site 881621002223 ABC transporter signature motif; other site 881621002224 Walker B; other site 881621002225 D-loop; other site 881621002226 H-loop/switch region; other site 881621002227 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 881621002228 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 881621002229 FMN binding site [chemical binding]; other site 881621002230 substrate binding site [chemical binding]; other site 881621002231 putative catalytic residue [active] 881621002232 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621002233 dimer interface [polypeptide binding]; other site 881621002234 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002235 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 881621002236 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002238 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621002239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002240 motif II; other site 881621002241 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002242 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621002243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621002244 Coenzyme A binding pocket [chemical binding]; other site 881621002245 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 881621002246 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621002247 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621002248 DNA binding residues [nucleotide binding] 881621002249 putative dimer interface [polypeptide binding]; other site 881621002250 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621002251 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621002252 active site 881621002253 catalytic tetrad [active] 881621002254 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002255 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002256 similar to Putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002257 similar to Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002258 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 881621002259 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 881621002260 homodimer interface [polypeptide binding]; other site 881621002261 catalytic residues [active] 881621002262 NAD binding site [chemical binding]; other site 881621002263 substrate binding pocket [chemical binding]; other site 881621002264 flexible flap; other site 881621002265 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 881621002266 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621002267 active site 881621002268 substrate binding site [chemical binding]; other site 881621002269 trimer interface [polypeptide binding]; other site 881621002270 CoA binding site [chemical binding]; other site 881621002271 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 881621002272 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002273 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002274 PhoU domain; Region: PhoU; pfam01895 881621002275 PhoU domain; Region: PhoU; pfam01895 881621002276 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 881621002277 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 881621002278 dimer interface [polypeptide binding]; other site 881621002279 PYR/PP interface [polypeptide binding]; other site 881621002280 TPP binding site [chemical binding]; other site 881621002281 substrate binding site [chemical binding]; other site 881621002282 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 881621002283 Domain of unknown function; Region: EKR; smart00890 881621002284 4Fe-4S binding domain; Region: Fer4_6; pfam12837 881621002285 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 881621002286 TPP-binding site [chemical binding]; other site 881621002287 dimer interface [polypeptide binding]; other site 881621002288 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 881621002289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621002290 YCII-related domain; Region: YCII; cl00999 881621002291 Predicted permeases [General function prediction only]; Region: COG0679 881621002292 Predicted membrane protein [Function unknown]; Region: COG3223 881621002293 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621002294 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621002295 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 881621002296 Walker A/P-loop; other site 881621002297 ATP binding site [chemical binding]; other site 881621002298 Q-loop/lid; other site 881621002299 ABC transporter signature motif; other site 881621002300 Walker B; other site 881621002301 D-loop; other site 881621002302 H-loop/switch region; other site 881621002303 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 881621002304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002305 putative substrate translocation pore; other site 881621002306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621002308 putative substrate translocation pore; other site 881621002309 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621002310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621002311 putative Zn2+ binding site [ion binding]; other site 881621002312 putative DNA binding site [nucleotide binding]; other site 881621002313 dimerization interface [polypeptide binding]; other site 881621002314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621002316 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002317 dimerization interface [polypeptide binding]; other site 881621002318 EamA-like transporter family; Region: EamA; pfam00892 881621002319 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 881621002320 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002321 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002322 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621002323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002324 motif II; other site 881621002325 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002326 similar to unknown protein (N-terminal part) 881621002327 similar to unknown protein (C-terminal part) 881621002328 Predicted membrane protein [Function unknown]; Region: COG3326 881621002329 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 881621002330 homotrimer interaction site [polypeptide binding]; other site 881621002331 putative active site [active] 881621002332 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 881621002333 substrate binding site [chemical binding]; other site 881621002334 zinc-binding site [ion binding]; other site 881621002335 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621002336 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621002337 GIY-YIG motif/motif A; other site 881621002338 active site 881621002339 catalytic site [active] 881621002340 putative DNA binding site [nucleotide binding]; other site 881621002341 metal binding site [ion binding]; metal-binding site 881621002342 UvrB/uvrC motif; Region: UVR; pfam02151 881621002343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621002344 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621002345 substrate binding pocket [chemical binding]; other site 881621002346 membrane-bound complex binding site; other site 881621002347 hinge residues; other site 881621002348 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621002349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002350 dimer interface [polypeptide binding]; other site 881621002351 conserved gate region; other site 881621002352 putative PBP binding loops; other site 881621002353 ABC-ATPase subunit interface; other site 881621002354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621002355 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 881621002356 Walker A/P-loop; other site 881621002357 ATP binding site [chemical binding]; other site 881621002358 Q-loop/lid; other site 881621002359 ABC transporter signature motif; other site 881621002360 Walker B; other site 881621002361 D-loop; other site 881621002362 H-loop/switch region; other site 881621002363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621002364 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002365 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002366 partial 881621002367 similar to internalin, putative peptidoglycan linked protein (LPXTG motif) 881621002368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621002370 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 881621002371 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 881621002372 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 881621002373 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 881621002374 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 881621002375 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 881621002376 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621002377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621002378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621002379 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 881621002380 Esterase/lipase [General function prediction only]; Region: COG1647 881621002381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002383 DNA binding site [nucleotide binding] 881621002384 domain linker motif; other site 881621002385 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 881621002386 putative dimerization interface [polypeptide binding]; other site 881621002387 putative ligand binding site [chemical binding]; other site 881621002388 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621002389 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621002390 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 881621002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002392 dimer interface [polypeptide binding]; other site 881621002393 conserved gate region; other site 881621002394 putative PBP binding loops; other site 881621002395 ABC-ATPase subunit interface; other site 881621002396 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621002397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002398 dimer interface [polypeptide binding]; other site 881621002399 conserved gate region; other site 881621002400 ABC-ATPase subunit interface; other site 881621002401 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621002402 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621002403 Ca binding site [ion binding]; other site 881621002404 active site 881621002405 catalytic site [active] 881621002406 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 881621002407 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 881621002408 active site 881621002409 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 881621002410 active site 881621002411 substrate binding site [chemical binding]; other site 881621002412 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621002413 metal binding site [ion binding]; metal-binding site 881621002414 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621002415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621002416 ATP binding site [chemical binding]; other site 881621002417 Mg++ binding site [ion binding]; other site 881621002418 motif III; other site 881621002419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621002420 nucleotide binding region [chemical binding]; other site 881621002421 ATP-binding site [chemical binding]; other site 881621002422 Viral enhancin protein; Region: Enhancin; pfam03272 881621002423 Peptidase M60-like family; Region: M60-like; pfam13402 881621002424 Viral enhancin protein; Region: Enhancin; pfam03272 881621002425 Peptidase M60-like family; Region: M60-like; pfam13402 881621002426 Viral enhancin protein; Region: Enhancin; pfam03272 881621002427 QueT transporter; Region: QueT; cl01932 881621002428 similar to unknown protein (C-terminal part) 881621002429 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 881621002430 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621002431 PRD domain; Region: PRD; pfam00874 881621002432 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621002433 active site 881621002434 P-loop; other site 881621002435 phosphorylation site [posttranslational modification] 881621002436 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002437 active site 881621002438 phosphorylation site [posttranslational modification] 881621002439 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002440 methionine cluster; other site 881621002441 active site 881621002442 phosphorylation site [posttranslational modification] 881621002443 metal binding site [ion binding]; metal-binding site 881621002444 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621002445 active site 881621002446 P-loop; other site 881621002447 phosphorylation site [posttranslational modification] 881621002448 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621002449 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002450 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 881621002451 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621002452 active site 881621002453 trimer interface [polypeptide binding]; other site 881621002454 allosteric site; other site 881621002455 active site lid [active] 881621002456 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621002458 active site 881621002459 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621002460 catalytic tetrad [active] 881621002461 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621002462 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 881621002463 Uncharacterized conserved protein [Function unknown]; Region: COG3402 881621002464 Predicted membrane protein [Function unknown]; Region: COG3428 881621002465 Bacterial PH domain; Region: DUF304; pfam03703 881621002466 Bacterial PH domain; Region: DUF304; pfam03703 881621002467 Bacterial PH domain; Region: DUF304; pfam03703 881621002468 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 881621002469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621002470 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 881621002471 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 881621002472 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 881621002473 active site 881621002474 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621002475 dimer interface [polypeptide binding]; other site 881621002476 substrate binding site [chemical binding]; other site 881621002477 catalytic residues [active] 881621002478 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 881621002479 PemK-like protein; Region: PemK; pfam02452 881621002480 Rsbr N terminal; Region: Rsbr_N; pfam08678 881621002481 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002482 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002483 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 881621002484 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 881621002485 ATP binding site [chemical binding]; other site 881621002486 Mg2+ binding site [ion binding]; other site 881621002487 G-X-G motif; other site 881621002488 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 881621002489 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 881621002490 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 881621002491 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 881621002492 anti sigma factor interaction site; other site 881621002493 regulatory phosphorylation site [posttranslational modification]; other site 881621002494 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 881621002495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002496 ATP binding site [chemical binding]; other site 881621002497 Mg2+ binding site [ion binding]; other site 881621002498 G-X-G motif; other site 881621002499 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 881621002500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621002501 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621002502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621002503 DNA binding residues [nucleotide binding] 881621002504 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 881621002505 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 881621002506 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 881621002507 Sulfate transporter family; Region: Sulfate_transp; pfam00916 881621002508 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621002509 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 881621002510 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 881621002511 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 881621002512 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 881621002513 RNA binding site [nucleotide binding]; other site 881621002514 hypothetical protein; Provisional; Region: PRK04351 881621002515 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 881621002516 Uncharacterized conserved protein [Function unknown]; Region: COG5646 881621002517 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621002518 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002519 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002521 DNA-binding site [nucleotide binding]; DNA binding site 881621002522 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 881621002523 OsmC-like protein; Region: OsmC; pfam02566 881621002524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 881621002525 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 881621002526 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 881621002527 glutathione reductase; Validated; Region: PRK06116 881621002528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621002529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621002530 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621002531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621002532 catalytic core [active] 881621002533 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621002534 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621002535 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621002536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002537 DNA-binding site [nucleotide binding]; DNA binding site 881621002538 Predicted membrane protein [General function prediction only]; Region: COG4194 881621002539 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 881621002540 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 881621002541 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 881621002542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621002543 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 881621002544 tetramerization interface [polypeptide binding]; other site 881621002545 NAD(P) binding site [chemical binding]; other site 881621002546 catalytic residues [active] 881621002547 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 881621002548 active site 881621002549 P-loop; other site 881621002550 phosphorylation site [posttranslational modification] 881621002551 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621002552 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621002553 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002554 methionine cluster; other site 881621002555 active site 881621002556 phosphorylation site [posttranslational modification] 881621002557 metal binding site [ion binding]; metal-binding site 881621002558 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621002559 beta-galactosidase; Region: BGL; TIGR03356 881621002560 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621002561 Mga helix-turn-helix domain; Region: Mga; pfam05043 881621002562 PRD domain; Region: PRD; pfam00874 881621002563 PRD domain; Region: PRD; pfam00874 881621002564 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002565 active site 881621002566 phosphorylation site [posttranslational modification] 881621002567 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621002568 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 881621002569 ABC transporter; Region: ABC_tran_2; pfam12848 881621002570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621002571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621002572 Predicted permeases [General function prediction only]; Region: COG0701 881621002573 Predicted membrane protein [Function unknown]; Region: COG3689 881621002574 pantothenate kinase; Provisional; Region: PRK05439 881621002575 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 881621002576 ATP-binding site [chemical binding]; other site 881621002577 CoA-binding site [chemical binding]; other site 881621002578 Mg2+-binding site [ion binding]; other site 881621002579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621002580 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 881621002581 Walker A/P-loop; other site 881621002582 ATP binding site [chemical binding]; other site 881621002583 Q-loop/lid; other site 881621002584 ABC transporter signature motif; other site 881621002585 Walker B; other site 881621002586 D-loop; other site 881621002587 H-loop/switch region; other site 881621002588 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621002589 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 881621002590 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 881621002591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621002593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621002594 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621002595 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621002596 Domain of unknown function (DUF373); Region: DUF373; cl12079 881621002597 Sulfatase; Region: Sulfatase; pfam00884 881621002598 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 881621002599 active site 881621002600 DNA binding site [nucleotide binding] 881621002601 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 881621002602 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621002603 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621002604 Uncharacterized conserved protein [Function unknown]; Region: COG0398 881621002605 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 881621002606 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 881621002607 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 881621002608 Ligand binding site; other site 881621002609 Putative Catalytic site; other site 881621002610 DXD motif; other site 881621002611 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 881621002612 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 881621002613 epoxyqueuosine reductase; Region: TIGR00276 881621002614 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 881621002615 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 881621002616 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 881621002617 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621002618 dimer interface [polypeptide binding]; other site 881621002619 FMN binding site [chemical binding]; other site 881621002620 NADPH bind site [chemical binding]; other site 881621002621 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 881621002622 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621002623 active site 881621002624 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 881621002625 similar to heat shock protein HtpG, C-terminal part 881621002626 similar to heat shock protein HtpG, N-terminal part 881621002627 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 881621002628 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 881621002629 dimerization interface [polypeptide binding]; other site 881621002630 DPS ferroxidase diiron center [ion binding]; other site 881621002631 ion pore; other site 881621002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 881621002633 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 881621002634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 881621002635 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 881621002636 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 881621002637 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 881621002638 hypothetical transport protein, C-terminal part 881621002639 hypothetical transport protein, N-terminal part 881621002640 Transcriptional regulators [Transcription]; Region: FadR; COG2186 881621002641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002642 DNA-binding site [nucleotide binding]; DNA binding site 881621002643 FCD domain; Region: FCD; pfam07729 881621002644 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621002645 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621002646 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 881621002647 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 881621002648 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 881621002649 Predicted transcriptional regulators [Transcription]; Region: COG1733 881621002650 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 881621002651 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 881621002652 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 881621002653 Predicted flavoprotein [General function prediction only]; Region: COG0431 881621002654 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 881621002655 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002656 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621002657 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 881621002658 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 881621002659 active site 881621002660 dimer interface [polypeptide binding]; other site 881621002661 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 881621002662 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621002663 active site 881621002664 trimer interface [polypeptide binding]; other site 881621002665 allosteric site; other site 881621002666 active site lid [active] 881621002667 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002668 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002670 DNA-binding site [nucleotide binding]; DNA binding site 881621002671 UTRA domain; Region: UTRA; pfam07702 881621002672 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 881621002673 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621002674 Mg++ binding site [ion binding]; other site 881621002675 putative catalytic motif [active] 881621002676 substrate binding site [chemical binding]; other site 881621002677 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 881621002678 Peptidase family U32; Region: Peptidase_U32; pfam01136 881621002679 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 881621002680 Peptidase family U32; Region: Peptidase_U32; pfam01136 881621002681 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 881621002682 heat shock protein HtpX; Provisional; Region: PRK04897 881621002683 similar to ABC transporter (ATP-binding protein),C-terminal part 881621002684 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 881621002685 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 881621002686 catalytic residues [active] 881621002687 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 881621002688 putative active site [active] 881621002689 putative metal binding residues [ion binding]; other site 881621002690 signature motif; other site 881621002691 putative triphosphate binding site [ion binding]; other site 881621002692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621002693 TPR motif; other site 881621002694 binding surface 881621002695 Tetratrico peptide repeat; Region: TPR_5; pfam12688 881621002696 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621002697 synthetase active site [active] 881621002698 NTP binding site [chemical binding]; other site 881621002699 metal binding site [ion binding]; metal-binding site 881621002700 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 881621002701 ATP-NAD kinase; Region: NAD_kinase; pfam01513 881621002702 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621002703 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 881621002704 active site 881621002705 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 881621002706 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 881621002707 NAD binding site [chemical binding]; other site 881621002708 homotetramer interface [polypeptide binding]; other site 881621002709 homodimer interface [polypeptide binding]; other site 881621002710 substrate binding site [chemical binding]; other site 881621002711 active site 881621002712 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 881621002713 DltD N-terminal region; Region: DltD_N; pfam04915 881621002714 DltD central region; Region: DltD_M; pfam04918 881621002715 DltD C-terminal region; Region: DltD_C; pfam04914 881621002716 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 881621002717 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 881621002718 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 881621002719 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 881621002720 acyl-activating enzyme (AAE) consensus motif; other site 881621002721 AMP binding site [chemical binding]; other site 881621002722 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 881621002723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621002724 active site 881621002725 dimer interface [polypeptide binding]; other site 881621002726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621002727 Coenzyme A binding pocket [chemical binding]; other site 881621002728 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 881621002729 Putative esterase; Region: Esterase; pfam00756 881621002730 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 881621002731 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 881621002732 homodimer interface [polypeptide binding]; other site 881621002733 substrate-cofactor binding pocket; other site 881621002734 catalytic residue [active] 881621002735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621002737 putative substrate translocation pore; other site 881621002738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002739 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621002740 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 881621002741 putative oligomer interface [polypeptide binding]; other site 881621002742 putative active site [active] 881621002743 metal binding site [ion binding]; metal-binding site 881621002744 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 881621002745 catalytic residues [active] 881621002746 dimer interface [polypeptide binding]; other site 881621002747 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 881621002748 LytTr DNA-binding domain; Region: LytTR; pfam04397 881621002749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621002750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621002751 Walker A/P-loop; other site 881621002752 ATP binding site [chemical binding]; other site 881621002753 Q-loop/lid; other site 881621002754 ABC transporter signature motif; other site 881621002755 Walker B; other site 881621002756 D-loop; other site 881621002757 H-loop/switch region; other site 881621002758 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 881621002759 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 881621002760 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 881621002761 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 881621002762 G1 box; other site 881621002763 putative GEF interaction site [polypeptide binding]; other site 881621002764 GTP/Mg2+ binding site [chemical binding]; other site 881621002765 Switch I region; other site 881621002766 G2 box; other site 881621002767 G3 box; other site 881621002768 Switch II region; other site 881621002769 G4 box; other site 881621002770 G5 box; other site 881621002771 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 881621002772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621002773 MarR family; Region: MarR_2; cl17246 881621002774 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621002775 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 881621002776 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 881621002777 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 881621002778 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 881621002779 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 881621002780 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 881621002781 Acyltransferase family; Region: Acyl_transf_3; pfam01757 881621002782 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 881621002783 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621002784 DNA binding site [nucleotide binding] 881621002785 active site 881621002786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002787 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 881621002788 Walker A motif; other site 881621002789 ATP binding site [chemical binding]; other site 881621002790 Walker B motif; other site 881621002791 arginine finger; other site 881621002792 UvrB/uvrC motif; Region: UVR; pfam02151 881621002793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621002794 Walker A motif; other site 881621002795 ATP binding site [chemical binding]; other site 881621002796 Walker B motif; other site 881621002797 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 881621002798 CAAX protease self-immunity; Region: Abi; pfam02517 881621002799 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 881621002800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 881621002801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 881621002802 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 881621002803 dimerization domain swap beta strand [polypeptide binding]; other site 881621002804 regulatory protein interface [polypeptide binding]; other site 881621002805 active site 881621002806 regulatory phosphorylation site [posttranslational modification]; other site 881621002807 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 881621002808 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 881621002809 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 881621002810 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 881621002811 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621002812 Uncharacterized conserved protein [Function unknown]; Region: COG1434 881621002813 putative active site [active] 881621002814 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 881621002815 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 881621002816 aminotransferase A; Validated; Region: PRK07683 881621002817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621002819 homodimer interface [polypeptide binding]; other site 881621002820 catalytic residue [active] 881621002821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 881621002822 FOG: CBS domain [General function prediction only]; Region: COG0517 881621002823 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 881621002824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621002826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621002827 dimerization interface [polypeptide binding]; other site 881621002828 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 881621002829 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 881621002830 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 881621002831 trimer interface [polypeptide binding]; other site 881621002832 active site 881621002833 substrate binding site [chemical binding]; other site 881621002834 CoA binding site [chemical binding]; other site 881621002835 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621002836 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 881621002837 metal binding site [ion binding]; metal-binding site 881621002838 putative dimer interface [polypeptide binding]; other site 881621002839 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 881621002840 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 881621002841 Mechanosensitive ion channel; Region: MS_channel; pfam00924 881621002842 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 881621002843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621002844 Walker A/P-loop; other site 881621002845 ATP binding site [chemical binding]; other site 881621002846 Q-loop/lid; other site 881621002847 ABC transporter signature motif; other site 881621002848 Walker B; other site 881621002849 D-loop; other site 881621002850 H-loop/switch region; other site 881621002851 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 881621002852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002853 dimer interface [polypeptide binding]; other site 881621002854 conserved gate region; other site 881621002855 putative PBP binding loops; other site 881621002856 ABC-ATPase subunit interface; other site 881621002857 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 881621002858 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621002859 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621002860 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 881621002861 HPr interaction site; other site 881621002862 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002863 active site 881621002864 phosphorylation site [posttranslational modification] 881621002865 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 881621002866 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 881621002867 S1 domain; Region: S1_2; pfam13509 881621002868 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 881621002869 Predicted membrane protein [Function unknown]; Region: COG4758 881621002870 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 881621002871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 881621002872 Histidine kinase; Region: HisKA_3; pfam07730 881621002873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002874 ATP binding site [chemical binding]; other site 881621002875 Mg2+ binding site [ion binding]; other site 881621002876 G-X-G motif; other site 881621002877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621002878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621002879 active site 881621002880 phosphorylation site [posttranslational modification] 881621002881 intermolecular recognition site; other site 881621002882 dimerization interface [polypeptide binding]; other site 881621002883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 881621002884 DNA binding residues [nucleotide binding] 881621002885 dimerization interface [polypeptide binding]; other site 881621002886 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 881621002887 TrkA-N domain; Region: TrkA_N; pfam02254 881621002888 TrkA-C domain; Region: TrkA_C; pfam02080 881621002889 Predicted membrane protein [Function unknown]; Region: COG1289 881621002890 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 881621002891 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621002892 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621002893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 881621002894 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621002895 hypothetical protein; Provisional; Region: PRK13667 881621002896 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621002897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002898 active site 881621002899 motif I; other site 881621002900 motif II; other site 881621002901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621002902 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002903 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002904 DNA binding site [nucleotide binding] 881621002905 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621002906 ligand binding site [chemical binding]; other site 881621002907 dimerization interface [polypeptide binding]; other site 881621002908 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 881621002909 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002910 trimer interface [polypeptide binding]; other site 881621002911 substrate binding site [chemical binding]; other site 881621002912 Mn binding site [ion binding]; other site 881621002913 transketolase; Reviewed; Region: PRK05899 881621002914 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621002915 TPP-binding site [chemical binding]; other site 881621002916 dimer interface [polypeptide binding]; other site 881621002917 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 881621002918 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621002919 PYR/PP interface [polypeptide binding]; other site 881621002920 dimer interface [polypeptide binding]; other site 881621002921 TPP binding site [chemical binding]; other site 881621002922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621002923 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 881621002924 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 881621002925 nucleotide binding site [chemical binding]; other site 881621002926 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621002927 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621002928 active site turn [active] 881621002929 phosphorylation site [posttranslational modification] 881621002930 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621002931 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 881621002932 HPr interaction site; other site 881621002933 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002934 active site 881621002935 phosphorylation site [posttranslational modification] 881621002936 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 881621002937 Protein of unknown function (DUF817); Region: DUF817; pfam05675 881621002938 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 881621002939 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 881621002940 GTP binding site; other site 881621002941 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 881621002942 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 881621002943 Walker A/P-loop; other site 881621002944 ATP binding site [chemical binding]; other site 881621002945 Q-loop/lid; other site 881621002946 ABC transporter signature motif; other site 881621002947 Walker B; other site 881621002948 D-loop; other site 881621002949 H-loop/switch region; other site 881621002950 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 881621002951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621002952 dimer interface [polypeptide binding]; other site 881621002953 conserved gate region; other site 881621002954 putative PBP binding loops; other site 881621002955 ABC-ATPase subunit interface; other site 881621002956 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 881621002957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 881621002958 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 881621002959 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 881621002960 dimer interface [polypeptide binding]; other site 881621002961 putative functional site; other site 881621002962 putative MPT binding site; other site 881621002963 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 881621002964 Walker A motif; other site 881621002965 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 881621002966 MoaE homodimer interface [polypeptide binding]; other site 881621002967 MoaD interaction [polypeptide binding]; other site 881621002968 active site residues [active] 881621002969 similar to molybdopterin converting factor (subunit 1), C-terminal part 881621002970 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 881621002971 trimer interface [polypeptide binding]; other site 881621002972 dimer interface [polypeptide binding]; other site 881621002973 putative active site [active] 881621002974 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 881621002975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621002976 FeS/SAM binding site; other site 881621002977 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 881621002978 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 881621002979 MPT binding site; other site 881621002980 trimer interface [polypeptide binding]; other site 881621002981 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 881621002982 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 881621002983 ATP binding site [chemical binding]; other site 881621002984 substrate interface [chemical binding]; other site 881621002985 similar to unknown protein, N-terminal part 881621002986 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 881621002987 active site 881621002988 catalytic residues [active] 881621002989 metal binding site [ion binding]; metal-binding site 881621002990 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 881621002991 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621002992 TPP-binding site [chemical binding]; other site 881621002993 tetramer interface [polypeptide binding]; other site 881621002994 heterodimer interface [polypeptide binding]; other site 881621002995 phosphorylation loop region [posttranslational modification] 881621002996 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621002997 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621002998 alpha subunit interface [polypeptide binding]; other site 881621002999 TPP binding site [chemical binding]; other site 881621003000 heterodimer interface [polypeptide binding]; other site 881621003001 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003002 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 881621003003 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621003004 E3 interaction surface; other site 881621003005 lipoyl attachment site [posttranslational modification]; other site 881621003006 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621003007 E3 interaction surface; other site 881621003008 lipoyl attachment site [posttranslational modification]; other site 881621003009 e3 binding domain; Region: E3_binding; pfam02817 881621003010 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 881621003011 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 881621003012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 881621003013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621003014 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621003015 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 881621003016 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 881621003017 NAD(P) binding site [chemical binding]; other site 881621003018 LDH/MDH dimer interface [polypeptide binding]; other site 881621003019 substrate binding site [chemical binding]; other site 881621003020 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 881621003021 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 881621003022 Thioredoxin; Region: Thioredoxin_4; pfam13462 881621003023 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 881621003024 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621003025 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 881621003026 Cl binding site [ion binding]; other site 881621003027 oligomer interface [polypeptide binding]; other site 881621003028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 881621003029 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 881621003030 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 881621003031 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 881621003032 active site 881621003033 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 881621003034 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 881621003035 G1 box; other site 881621003036 putative GEF interaction site [polypeptide binding]; other site 881621003037 GTP/Mg2+ binding site [chemical binding]; other site 881621003038 Switch I region; other site 881621003039 G2 box; other site 881621003040 G3 box; other site 881621003041 Switch II region; other site 881621003042 G4 box; other site 881621003043 G5 box; other site 881621003044 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 881621003045 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 881621003046 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 881621003047 amidase catalytic site [active] 881621003048 Zn binding residues [ion binding]; other site 881621003049 substrate binding site [chemical binding]; other site 881621003050 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003051 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003052 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003053 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003054 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003055 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 881621003057 hypothetical protein; Provisional; Region: PRK13666 881621003058 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 881621003059 pyruvate carboxylase; Reviewed; Region: PRK12999 881621003060 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621003061 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 881621003062 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 881621003063 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 881621003064 active site 881621003065 catalytic residues [active] 881621003066 metal binding site [ion binding]; metal-binding site 881621003067 homodimer binding site [polypeptide binding]; other site 881621003068 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 881621003069 carboxyltransferase (CT) interaction site; other site 881621003070 biotinylation site [posttranslational modification]; other site 881621003071 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 881621003072 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 881621003073 putative binding site residues; other site 881621003074 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 881621003075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 881621003076 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 881621003077 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 881621003078 Walker A/P-loop; other site 881621003079 ATP binding site [chemical binding]; other site 881621003080 Q-loop/lid; other site 881621003081 ABC transporter signature motif; other site 881621003082 Walker B; other site 881621003083 D-loop; other site 881621003084 H-loop/switch region; other site 881621003085 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621003086 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003087 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003088 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621003089 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621003090 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 881621003091 Lysozyme subfamily 2; Region: LYZ2; smart00047 881621003092 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 881621003093 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 881621003094 Ligand binding site; other site 881621003095 Putative Catalytic site; other site 881621003096 DXD motif; other site 881621003097 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 881621003098 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 881621003099 active site 881621003100 tetramer interface; other site 881621003101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621003102 active site 881621003103 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621003104 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621003105 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621003106 substrate binding site; other site 881621003107 dimer interface; other site 881621003108 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 881621003109 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621003110 putative NAD(P) binding site [chemical binding]; other site 881621003111 putative catalytic Zn binding site [ion binding]; other site 881621003112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621003113 active site 881621003114 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621003115 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621003116 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621003117 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621003118 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 881621003119 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 881621003120 active site 881621003121 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 881621003122 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 881621003123 homodimer interface [polypeptide binding]; other site 881621003124 NAD binding pocket [chemical binding]; other site 881621003125 ATP binding pocket [chemical binding]; other site 881621003126 Mg binding site [ion binding]; other site 881621003127 active-site loop [active] 881621003128 Uncharacterized conserved protein [Function unknown]; Region: COG1359 881621003129 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 881621003130 active site 881621003131 P-loop; other site 881621003132 phosphorylation site [posttranslational modification] 881621003133 GMP synthase; Reviewed; Region: guaA; PRK00074 881621003134 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 881621003135 AMP/PPi binding site [chemical binding]; other site 881621003136 candidate oxyanion hole; other site 881621003137 catalytic triad [active] 881621003138 potential glutamine specificity residues [chemical binding]; other site 881621003139 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 881621003140 ATP Binding subdomain [chemical binding]; other site 881621003141 Dimerization subdomain; other site 881621003142 similar to transposase 881621003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 881621003144 Transposase; Region: HTH_Tnp_1; cl17663 881621003145 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621003146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621003148 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621003149 active site 881621003150 similar to unknown protein, N-terminal part 881621003151 similar to unknown protein, central part 881621003152 similar to unknown protein, C-terminal part 881621003153 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 881621003154 similar to unknown protein, partial sequence 881621003155 similar to unknown protein, partial 881621003156 Partial, C-terminal part 881621003157 similar to unknown protein, N-terminal part 881621003158 MepB protein; Region: MepB; cl01985 881621003159 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 881621003160 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621003161 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621003162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621003163 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621003164 Coenzyme A binding pocket [chemical binding]; other site 881621003165 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003166 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 881621003167 DNA binding residues [nucleotide binding] 881621003168 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621003169 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621003170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621003171 Walker A/P-loop; other site 881621003172 ATP binding site [chemical binding]; other site 881621003173 Q-loop/lid; other site 881621003174 ABC transporter signature motif; other site 881621003175 Walker B; other site 881621003176 D-loop; other site 881621003177 H-loop/switch region; other site 881621003178 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621003179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621003180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621003181 Walker A/P-loop; other site 881621003182 ATP binding site [chemical binding]; other site 881621003183 Q-loop/lid; other site 881621003184 ABC transporter signature motif; other site 881621003185 Walker B; other site 881621003186 D-loop; other site 881621003187 H-loop/switch region; other site 881621003188 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 881621003189 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621003190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621003191 active site turn [active] 881621003192 phosphorylation site [posttranslational modification] 881621003193 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621003194 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 881621003195 NAD binding site [chemical binding]; other site 881621003196 sugar binding site [chemical binding]; other site 881621003197 divalent metal binding site [ion binding]; other site 881621003198 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621003199 dimer interface [polypeptide binding]; other site 881621003200 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621003201 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621003202 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621003203 putative active site [active] 881621003204 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 881621003205 HPr interaction site; other site 881621003206 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621003207 active site 881621003208 phosphorylation site [posttranslational modification] 881621003209 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621003210 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621003211 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621003212 DNA binding residues [nucleotide binding] 881621003213 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003214 putative dimer interface [polypeptide binding]; other site 881621003215 weakly similar to inorganic pyrophosphatase,C-terminal part 881621003216 similar to beta-glucosidase, C-terminal part 881621003217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 881621003218 Clp protease; Region: CLP_protease; pfam00574 881621003219 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621003220 oligomer interface [polypeptide binding]; other site 881621003221 active site residues [active] 881621003222 similar to unknown protein, C-terminal part 881621003223 similar to unknown protein, N-terminal part 881621003224 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 881621003225 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 881621003226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621003227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621003228 Bacterial transcriptional repressor; Region: TetR; pfam13972 881621003229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003230 short chain dehydrogenase; Provisional; Region: PRK06197 881621003231 NAD(P) binding site [chemical binding]; other site 881621003232 active site 881621003233 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 881621003234 SLBB domain; Region: SLBB; pfam10531 881621003235 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 881621003236 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 881621003237 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003238 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621003239 putative hexamer interface [polypeptide binding]; other site 881621003240 putative hexagonal pore; other site 881621003241 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621003242 putative hexamer interface [polypeptide binding]; other site 881621003243 putative hexagonal pore; other site 881621003244 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 881621003245 putative hexamer interface [polypeptide binding]; other site 881621003246 putative hexagonal pore; other site 881621003247 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 881621003248 G1 box; other site 881621003249 GTP/Mg2+ binding site [chemical binding]; other site 881621003250 G2 box; other site 881621003251 Switch I region; other site 881621003252 G3 box; other site 881621003253 Switch II region; other site 881621003254 G4 box; other site 881621003255 G5 box; other site 881621003256 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 881621003257 homotrimer interface [polypeptide binding]; other site 881621003258 Walker A motif; other site 881621003259 GTP binding site [chemical binding]; other site 881621003260 Walker B motif; other site 881621003261 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 881621003262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003263 catalytic core [active] 881621003264 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003265 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003266 Hexamer interface [polypeptide binding]; other site 881621003267 Hexagonal pore residue; other site 881621003268 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 881621003269 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 881621003270 putative hexamer interface [polypeptide binding]; other site 881621003271 putative hexagonal pore; other site 881621003272 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 881621003273 putative hexamer interface [polypeptide binding]; other site 881621003274 putative hexagonal pore; other site 881621003275 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 881621003276 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 881621003277 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 881621003278 alpha-beta subunit interface [polypeptide binding]; other site 881621003279 alpha-gamma subunit interface [polypeptide binding]; other site 881621003280 active site 881621003281 substrate and K+ binding site; other site 881621003282 K+ binding site [ion binding]; other site 881621003283 cobalamin binding site [chemical binding]; other site 881621003284 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 881621003285 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 881621003286 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 881621003287 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 881621003288 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003289 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 881621003290 putative hexamer interface [polypeptide binding]; other site 881621003291 putative hexagonal pore; other site 881621003292 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003293 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003294 Hexamer interface [polypeptide binding]; other site 881621003295 Hexagonal pore residue; other site 881621003296 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003297 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003298 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003299 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 881621003300 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621003301 nucleotide binding site [chemical binding]; other site 881621003302 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 881621003303 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 881621003304 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003305 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003306 central pore; other site 881621003307 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 881621003308 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 881621003309 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 881621003310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621003311 putative catalytic cysteine [active] 881621003312 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003313 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003314 putative active site [active] 881621003315 metal binding site [ion binding]; metal-binding site 881621003316 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 881621003317 amphipathic channel; other site 881621003318 Asn-Pro-Ala signature motifs; other site 881621003319 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 881621003320 propionate/acetate kinase; Provisional; Region: PRK12379 881621003321 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 881621003322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621003323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003324 homodimer interface [polypeptide binding]; other site 881621003325 catalytic residue [active] 881621003326 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 881621003327 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621003328 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003329 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003330 putative active site [active] 881621003331 metal binding site [ion binding]; metal-binding site 881621003332 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 881621003333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621003334 active site 881621003335 phosphorylation site [posttranslational modification] 881621003336 intermolecular recognition site; other site 881621003337 dimerization interface [polypeptide binding]; other site 881621003338 ANTAR domain; Region: ANTAR; pfam03861 881621003339 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 881621003340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 881621003341 Histidine kinase; Region: HisKA_2; pfam07568 881621003342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003343 ATP binding site [chemical binding]; other site 881621003344 Mg2+ binding site [ion binding]; other site 881621003345 G-X-G motif; other site 881621003346 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 881621003347 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 881621003348 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 881621003349 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 881621003350 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 881621003351 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 881621003352 putative hexamer interface [polypeptide binding]; other site 881621003353 putative hexagonal pore; other site 881621003354 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 881621003355 putative hexamer interface [polypeptide binding]; other site 881621003356 putative hexagonal pore; other site 881621003357 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003358 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003359 Hexamer interface [polypeptide binding]; other site 881621003360 Hexagonal pore residue; other site 881621003361 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621003362 putative catalytic cysteine [active] 881621003363 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003364 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 881621003365 Hexamer interface [polypeptide binding]; other site 881621003366 Putative hexagonal pore residue; other site 881621003367 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 881621003368 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003369 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003370 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003371 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 881621003372 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003373 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003374 central pore; other site 881621003375 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 881621003376 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621003377 putative hexamer interface [polypeptide binding]; other site 881621003378 putative hexagonal pore; other site 881621003379 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621003380 putative hexamer interface [polypeptide binding]; other site 881621003381 putative hexagonal pore; other site 881621003382 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 881621003383 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 881621003384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003385 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621003386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003387 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 881621003388 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 881621003389 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 881621003390 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 881621003391 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 881621003392 catalytic triad [active] 881621003393 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 881621003394 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 881621003395 Precorrin-8X methylmutase; Region: CbiC; pfam02570 881621003396 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 881621003397 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 881621003398 active site 881621003399 putative homodimer interface [polypeptide binding]; other site 881621003400 SAM binding site [chemical binding]; other site 881621003401 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 881621003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621003403 S-adenosylmethionine binding site [chemical binding]; other site 881621003404 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 881621003405 active site 881621003406 SAM binding site [chemical binding]; other site 881621003407 homodimer interface [polypeptide binding]; other site 881621003408 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 881621003409 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 881621003410 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 881621003411 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 881621003412 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 881621003413 active site 881621003414 SAM binding site [chemical binding]; other site 881621003415 homodimer interface [polypeptide binding]; other site 881621003416 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 881621003417 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 881621003418 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 881621003419 active site 881621003420 SAM binding site [chemical binding]; other site 881621003421 homodimer interface [polypeptide binding]; other site 881621003422 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 881621003423 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 881621003424 active site 881621003425 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 881621003426 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 881621003427 active site 881621003428 C-terminal domain interface [polypeptide binding]; other site 881621003429 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 881621003430 active site 881621003431 N-terminal domain interface [polypeptide binding]; other site 881621003432 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 881621003433 active site 881621003434 SAM binding site [chemical binding]; other site 881621003435 homodimer interface [polypeptide binding]; other site 881621003436 cobalt transport protein CbiM; Validated; Region: PRK08319 881621003437 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 881621003438 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 881621003439 cobalt transport protein CbiQ; Provisional; Region: PRK15485 881621003440 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 881621003441 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 881621003442 Walker A/P-loop; other site 881621003443 ATP binding site [chemical binding]; other site 881621003444 Q-loop/lid; other site 881621003445 ABC transporter signature motif; other site 881621003446 Walker B; other site 881621003447 D-loop; other site 881621003448 H-loop/switch region; other site 881621003449 cobyric acid synthase; Provisional; Region: PRK00784 881621003450 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 881621003451 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 881621003452 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 881621003453 catalytic triad [active] 881621003454 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 881621003455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 881621003456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 881621003457 topology modulation protein; Reviewed; Region: PRK08118 881621003458 AAA domain; Region: AAA_17; pfam13207 881621003459 Predicted transcriptional regulators [Transcription]; Region: COG1695 881621003460 Transcriptional regulator PadR-like family; Region: PadR; cl17335 881621003461 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 881621003462 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621003463 Transcriptional regulator; Region: Rrf2; pfam02082 881621003464 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621003465 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621003466 NAD binding site [chemical binding]; other site 881621003467 substrate binding site [chemical binding]; other site 881621003468 putative active site [active] 881621003469 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 881621003470 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 881621003471 SH3-like domain; Region: SH3_8; pfam13457 881621003472 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 881621003473 SH3-like domain; Region: SH3_8; pfam13457 881621003474 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621003475 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621003476 oligomer interface [polypeptide binding]; other site 881621003477 active site 881621003478 metal binding site [ion binding]; metal-binding site 881621003479 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 881621003480 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 881621003481 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 881621003482 Predicted transcriptional regulators [Transcription]; Region: COG1733 881621003483 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 881621003484 Transposase domain (DUF772); Region: DUF772; pfam05598 881621003485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 881621003486 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 881621003487 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 881621003488 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 881621003489 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 881621003490 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 881621003491 dimer interface [polypeptide binding]; other site 881621003492 motif 1; other site 881621003493 active site 881621003494 motif 2; other site 881621003495 motif 3; other site 881621003496 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 881621003497 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621003498 putative tRNA-binding site [nucleotide binding]; other site 881621003499 B3/4 domain; Region: B3_4; pfam03483 881621003500 tRNA synthetase B5 domain; Region: B5; smart00874 881621003501 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 881621003502 dimer interface [polypeptide binding]; other site 881621003503 motif 1; other site 881621003504 motif 3; other site 881621003505 motif 2; other site 881621003506 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 881621003507 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621003508 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621003509 Walker A/P-loop; other site 881621003510 ATP binding site [chemical binding]; other site 881621003511 Q-loop/lid; other site 881621003512 ABC transporter signature motif; other site 881621003513 Walker B; other site 881621003514 D-loop; other site 881621003515 H-loop/switch region; other site 881621003516 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621003517 FtsX-like permease family; Region: FtsX; pfam02687 881621003518 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 881621003519 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621003520 FtsX-like permease family; Region: FtsX; pfam02687 881621003521 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621003522 MarR family; Region: MarR; pfam01047 881621003523 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 881621003524 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 881621003525 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621003526 ligand binding site [chemical binding]; other site 881621003527 active site 881621003528 UGI interface [polypeptide binding]; other site 881621003529 catalytic site [active] 881621003530 ribonuclease HIII; Provisional; Region: PRK00996 881621003531 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 881621003532 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 881621003533 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003534 active site 881621003535 Cell division protein ZapA; Region: ZapA; cl01146 881621003536 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 881621003537 Colicin V production protein; Region: Colicin_V; pfam02674 881621003538 hypothetical protein; Provisional; Region: PRK08609 881621003539 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 881621003540 active site 881621003541 primer binding site [nucleotide binding]; other site 881621003542 NTP binding site [chemical binding]; other site 881621003543 metal binding triad [ion binding]; metal-binding site 881621003544 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 881621003545 active site 881621003546 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 881621003547 MutS domain III; Region: MutS_III; pfam05192 881621003548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621003549 Walker A/P-loop; other site 881621003550 ATP binding site [chemical binding]; other site 881621003551 Q-loop/lid; other site 881621003552 ABC transporter signature motif; other site 881621003553 Walker B; other site 881621003554 D-loop; other site 881621003555 H-loop/switch region; other site 881621003556 Smr domain; Region: Smr; pfam01713 881621003557 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621003558 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 881621003559 catalytic residues [active] 881621003560 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621003561 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621003562 GIY-YIG motif/motif A; other site 881621003563 active site 881621003564 catalytic site [active] 881621003565 putative DNA binding site [nucleotide binding]; other site 881621003566 metal binding site [ion binding]; metal-binding site 881621003567 UvrB/uvrC motif; Region: UVR; pfam02151 881621003568 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 881621003569 aspartate kinase; Reviewed; Region: PRK06635 881621003570 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 881621003571 putative catalytic residues [active] 881621003572 putative nucleotide binding site [chemical binding]; other site 881621003573 putative aspartate binding site [chemical binding]; other site 881621003574 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 881621003575 putative allosteric regulatory site; other site 881621003576 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 881621003577 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 881621003578 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 881621003579 ribonuclease PH; Reviewed; Region: rph; PRK00173 881621003580 Ribonuclease PH; Region: RNase_PH_bact; cd11362 881621003581 hexamer interface [polypeptide binding]; other site 881621003582 active site 881621003583 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003584 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003585 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003586 Leucine-rich repeats; other site 881621003587 Substrate binding site [chemical binding]; other site 881621003588 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003589 SH3-like domain; Region: SH3_8; pfam13457 881621003590 SH3-like domain; Region: SH3_8; pfam13457 881621003591 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003592 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003593 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003594 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003595 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003596 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003597 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003598 Leucine rich repeat; Region: LRR_8; pfam13855 881621003599 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003600 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003601 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003602 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003603 Leucine rich repeat; Region: LRR_8; pfam13855 881621003604 Substrate binding site [chemical binding]; other site 881621003605 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003606 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003607 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003608 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003609 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003610 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003611 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003612 SH3-like domain; Region: SH3_8; pfam13457 881621003613 SH3-like domain; Region: SH3_8; pfam13457 881621003614 SH3-like domain; Region: SH3_8; pfam13457 881621003615 SH3-like domain; Region: SH3_8; pfam13457 881621003616 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003619 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621003620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003621 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003622 Leucine rich repeat; Region: LRR_8; pfam13855 881621003623 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003625 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003626 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003627 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003628 Leucine rich repeat; Region: LRR_8; pfam13855 881621003629 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003630 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003631 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003632 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003633 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003634 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003635 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003636 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 881621003637 putative catalytic site [active] 881621003638 metal binding site A [ion binding]; metal-binding site 881621003639 phosphate binding site [ion binding]; other site 881621003640 metal binding site C [ion binding]; metal-binding site 881621003641 metal binding site B [ion binding]; metal-binding site 881621003642 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003643 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003644 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003645 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003646 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003647 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003648 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003649 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 881621003651 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 881621003652 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 881621003653 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621003654 dimer interface [polypeptide binding]; other site 881621003655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621003656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003657 catalytic core [active] 881621003658 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 881621003659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621003660 ATP binding site [chemical binding]; other site 881621003661 Mg++ binding site [ion binding]; other site 881621003662 motif III; other site 881621003663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621003664 nucleotide binding region [chemical binding]; other site 881621003665 ATP-binding site [chemical binding]; other site 881621003666 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 881621003667 RNA binding site [nucleotide binding]; other site 881621003668 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621003669 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 881621003670 putative active site [active] 881621003671 nucleotide binding site [chemical binding]; other site 881621003672 nudix motif; other site 881621003673 putative metal binding site [ion binding]; other site 881621003674 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621003675 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 881621003676 classical (c) SDRs; Region: SDR_c; cd05233 881621003677 NAD(P) binding site [chemical binding]; other site 881621003678 active site 881621003679 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003680 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621003681 DNA binding residues [nucleotide binding] 881621003682 putative dimer interface [polypeptide binding]; other site 881621003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621003684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621003685 putative substrate translocation pore; other site 881621003686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621003687 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621003688 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621003689 ligand binding site [chemical binding]; other site 881621003690 flexible hinge region; other site 881621003691 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621003692 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621003693 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621003694 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621003695 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 881621003696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621003697 DNA-binding site [nucleotide binding]; DNA binding site 881621003698 UTRA domain; Region: UTRA; pfam07702 881621003699 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621003700 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 881621003701 Ca binding site [ion binding]; other site 881621003702 active site 881621003703 catalytic site [active] 881621003704 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 881621003705 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 881621003706 active site turn [active] 881621003707 phosphorylation site [posttranslational modification] 881621003708 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 881621003709 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 881621003710 nudix motif; other site 881621003711 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 881621003712 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621003713 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 881621003714 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 881621003715 putative catalytic cysteine [active] 881621003716 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 881621003717 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 881621003718 nucleotide binding site [chemical binding]; other site 881621003719 homotetrameric interface [polypeptide binding]; other site 881621003720 putative phosphate binding site [ion binding]; other site 881621003721 putative allosteric binding site; other site 881621003722 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 881621003723 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 881621003724 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621003725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003726 non-specific DNA binding site [nucleotide binding]; other site 881621003727 salt bridge; other site 881621003728 sequence-specific DNA binding site [nucleotide binding]; other site 881621003729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003730 non-specific DNA binding site [nucleotide binding]; other site 881621003731 salt bridge; other site 881621003732 sequence-specific DNA binding site [nucleotide binding]; other site 881621003733 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621003734 active site 881621003735 trigger factor; Provisional; Region: tig; PRK01490 881621003736 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 881621003737 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 881621003738 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 881621003739 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 881621003740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621003741 Walker A motif; other site 881621003742 ATP binding site [chemical binding]; other site 881621003743 Walker B motif; other site 881621003744 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 881621003745 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003746 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003747 Catalytic site [active] 881621003748 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003749 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003750 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003751 Catalytic site [active] 881621003752 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 881621003753 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003755 Catalytic site [active] 881621003756 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 881621003757 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 881621003758 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003759 active site 881621003760 DNA protecting protein DprA; Region: dprA; TIGR00732 881621003761 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 881621003762 DNA topoisomerase I; Validated; Region: PRK05582 881621003763 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 881621003764 active site 881621003765 interdomain interaction site; other site 881621003766 putative metal-binding site [ion binding]; other site 881621003767 nucleotide binding site [chemical binding]; other site 881621003768 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 881621003769 domain I; other site 881621003770 DNA binding groove [nucleotide binding] 881621003771 phosphate binding site [ion binding]; other site 881621003772 domain II; other site 881621003773 domain III; other site 881621003774 nucleotide binding site [chemical binding]; other site 881621003775 catalytic site [active] 881621003776 domain IV; other site 881621003777 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 881621003778 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 881621003779 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 881621003780 Glucose inhibited division protein A; Region: GIDA; pfam01134 881621003781 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 881621003782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 881621003783 active site 881621003784 DNA binding site [nucleotide binding] 881621003785 Int/Topo IB signature motif; other site 881621003786 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 881621003787 active site 881621003788 HslU subunit interaction site [polypeptide binding]; other site 881621003789 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 881621003790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621003791 Walker A motif; other site 881621003792 ATP binding site [chemical binding]; other site 881621003793 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 881621003794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 881621003795 transcriptional repressor CodY; Validated; Region: PRK04158 881621003796 CodY GAF-like domain; Region: CodY; pfam06018 881621003797 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 881621003798 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 881621003799 active site 881621003800 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 881621003801 active site 881621003802 catalytic residues [active] 881621003803 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 881621003804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003805 Mg2+ binding site [ion binding]; other site 881621003806 G-X-G motif; other site 881621003807 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 881621003808 anchoring element; other site 881621003809 dimer interface [polypeptide binding]; other site 881621003810 ATP binding site [chemical binding]; other site 881621003811 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621003812 active site 881621003813 putative metal-binding site [ion binding]; other site 881621003814 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621003815 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 881621003816 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 881621003817 CAP-like domain; other site 881621003818 active site 881621003819 primary dimer interface [polypeptide binding]; other site 881621003820 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621003821 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 881621003822 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 881621003823 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 881621003824 catalytic triad [active] 881621003825 catalytic triad [active] 881621003826 oxyanion hole [active] 881621003827 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 881621003828 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 881621003829 active site 881621003830 catalytic site [active] 881621003831 metal binding site [ion binding]; metal-binding site 881621003832 dimer interface [polypeptide binding]; other site 881621003833 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 881621003834 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 881621003835 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 881621003836 bacterial Hfq-like; Region: Hfq; cd01716 881621003837 hexamer interface [polypeptide binding]; other site 881621003838 Sm1 motif; other site 881621003839 RNA binding site [nucleotide binding]; other site 881621003840 Sm2 motif; other site 881621003841 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 881621003842 Aluminium resistance protein; Region: Alum_res; pfam06838 881621003843 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 881621003844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 881621003845 DNA binding residues [nucleotide binding] 881621003846 putative dimer interface [polypeptide binding]; other site 881621003847 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 881621003848 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 881621003849 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 881621003850 arsenical pump membrane protein; Provisional; Region: PRK15445 881621003851 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 881621003852 transmembrane helices; other site 881621003853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621003854 LexA repressor; Validated; Region: PRK00215 881621003855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621003856 putative DNA binding site [nucleotide binding]; other site 881621003857 putative Zn2+ binding site [ion binding]; other site 881621003858 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 881621003859 Catalytic site [active] 881621003860 cell division suppressor protein YneA; Provisional; Region: PRK14125 881621003861 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 881621003862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 881621003863 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 881621003864 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621003865 TPP-binding site [chemical binding]; other site 881621003866 dimer interface [polypeptide binding]; other site 881621003867 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621003868 PYR/PP interface [polypeptide binding]; other site 881621003869 dimer interface [polypeptide binding]; other site 881621003870 TPP binding site [chemical binding]; other site 881621003871 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003872 hypothetical protein; Provisional; Region: PRK01844 881621003873 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 881621003874 weakly similar to arginine N-methyltransferases,C-terminal part 881621003875 weakly similar to arginine N-methyltransferases,N-terminal part 881621003876 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 881621003877 ParB-like nuclease domain; Region: ParBc; pfam02195 881621003878 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 881621003879 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 881621003880 Active Sites [active] 881621003881 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 881621003882 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621003883 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 881621003884 putative nucleotide binding site [chemical binding]; other site 881621003885 uridine monophosphate binding site [chemical binding]; other site 881621003886 homohexameric interface [polypeptide binding]; other site 881621003887 ribosome recycling factor; Reviewed; Region: frr; PRK00083 881621003888 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 881621003889 hinge region; other site 881621003890 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 881621003891 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 881621003892 catalytic residue [active] 881621003893 putative FPP diphosphate binding site; other site 881621003894 putative FPP binding hydrophobic cleft; other site 881621003895 dimer interface [polypeptide binding]; other site 881621003896 putative IPP diphosphate binding site; other site 881621003897 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 881621003898 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 881621003899 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 881621003900 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 881621003901 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 881621003902 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 881621003903 prolyl-tRNA synthetase; Provisional; Region: PRK09194 881621003904 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 881621003905 dimer interface [polypeptide binding]; other site 881621003906 motif 1; other site 881621003907 active site 881621003908 motif 2; other site 881621003909 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 881621003910 putative deacylase active site [active] 881621003911 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 881621003912 active site 881621003913 motif 3; other site 881621003914 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 881621003915 anticodon binding site; other site 881621003916 DNA polymerase III PolC; Validated; Region: polC; PRK00448 881621003917 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 881621003918 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 881621003919 generic binding surface II; other site 881621003920 generic binding surface I; other site 881621003921 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 881621003922 active site 881621003923 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621003924 active site 881621003925 catalytic site [active] 881621003926 substrate binding site [chemical binding]; other site 881621003927 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 881621003928 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 881621003929 NusA N-terminal domain; Region: NusA_N; pfam08529 881621003930 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 881621003931 RNA binding site [nucleotide binding]; other site 881621003932 homodimer interface [polypeptide binding]; other site 881621003933 NusA-like KH domain; Region: KH_5; pfam13184 881621003934 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 881621003935 G-X-X-G motif; other site 881621003936 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 881621003937 putative RNA binding cleft [nucleotide binding]; other site 881621003938 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003939 translation initiation factor IF-2; Region: IF-2; TIGR00487 881621003940 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003941 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 881621003942 G1 box; other site 881621003943 putative GEF interaction site [polypeptide binding]; other site 881621003944 GTP/Mg2+ binding site [chemical binding]; other site 881621003945 Switch I region; other site 881621003946 G2 box; other site 881621003947 G3 box; other site 881621003948 Switch II region; other site 881621003949 G4 box; other site 881621003950 G5 box; other site 881621003951 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 881621003952 Translation-initiation factor 2; Region: IF-2; pfam11987 881621003953 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 881621003954 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 881621003955 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 881621003956 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 881621003957 RNA binding site [nucleotide binding]; other site 881621003958 active site 881621003959 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 881621003960 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621003961 active site 881621003962 Riboflavin kinase; Region: Flavokinase; smart00904 881621003963 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 881621003964 16S/18S rRNA binding site [nucleotide binding]; other site 881621003965 S13e-L30e interaction site [polypeptide binding]; other site 881621003966 25S rRNA binding site [nucleotide binding]; other site 881621003967 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 881621003968 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 881621003969 RNase E interface [polypeptide binding]; other site 881621003970 trimer interface [polypeptide binding]; other site 881621003971 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 881621003972 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 881621003973 RNase E interface [polypeptide binding]; other site 881621003974 trimer interface [polypeptide binding]; other site 881621003975 active site 881621003976 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 881621003977 putative nucleic acid binding region [nucleotide binding]; other site 881621003978 G-X-X-G motif; other site 881621003979 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 881621003980 RNA binding site [nucleotide binding]; other site 881621003981 domain interface; other site 881621003982 GTPase RsgA; Reviewed; Region: PRK01889 881621003983 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621003984 RNA binding site [nucleotide binding]; other site 881621003985 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 881621003986 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621003987 GTP/Mg2+ binding site [chemical binding]; other site 881621003988 G4 box; other site 881621003989 G5 box; other site 881621003990 G1 box; other site 881621003991 Switch I region; other site 881621003992 G2 box; other site 881621003993 G3 box; other site 881621003994 Switch II region; other site 881621003995 YceG-like family; Region: YceG; pfam02618 881621003996 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 881621003997 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 881621003998 Rhomboid family; Region: Rhomboid; pfam01694 881621003999 TPR repeat; Region: TPR_11; pfam13414 881621004000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 881621004001 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 881621004002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621004003 nucleotide binding site [chemical binding]; other site 881621004004 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 881621004005 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 881621004006 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 881621004007 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 881621004008 Type II/IV secretion system protein; Region: T2SE; pfam00437 881621004009 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 881621004010 Walker A motif; other site 881621004011 ATP binding site [chemical binding]; other site 881621004012 Walker B motif; other site 881621004013 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 881621004014 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 881621004015 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 881621004016 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 881621004017 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 881621004018 tetramer interface [polypeptide binding]; other site 881621004019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004020 catalytic residue [active] 881621004021 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 881621004022 tetramer interface [polypeptide binding]; other site 881621004023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004024 catalytic residue [active] 881621004025 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621004026 active site residue [active] 881621004027 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 881621004028 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621004029 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621004030 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621004031 active site 881621004032 elongation factor P; Validated; Region: PRK00529 881621004033 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 881621004034 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 881621004035 RNA binding site [nucleotide binding]; other site 881621004036 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 881621004037 RNA binding site [nucleotide binding]; other site 881621004038 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 881621004039 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 881621004040 carboxyltransferase (CT) interaction site; other site 881621004041 biotinylation site [posttranslational modification]; other site 881621004042 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 881621004043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621004044 ATP-grasp domain; Region: ATP-grasp_4; cl17255 881621004045 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 881621004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 881621004047 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 881621004048 putative RNA binding site [nucleotide binding]; other site 881621004049 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 881621004050 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 881621004051 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 881621004052 homodimer interface [polypeptide binding]; other site 881621004053 NADP binding site [chemical binding]; other site 881621004054 substrate binding site [chemical binding]; other site 881621004055 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 881621004056 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 881621004057 generic binding surface II; other site 881621004058 generic binding surface I; other site 881621004059 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 881621004060 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621004061 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621004062 substrate binding pocket [chemical binding]; other site 881621004063 chain length determination region; other site 881621004064 substrate-Mg2+ binding site; other site 881621004065 catalytic residues [active] 881621004066 aspartate-rich region 1; other site 881621004067 active site lid residues [active] 881621004068 aspartate-rich region 2; other site 881621004069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 881621004070 DNA-binding site [nucleotide binding]; DNA binding site 881621004071 RNA-binding motif; other site 881621004072 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 881621004073 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 881621004074 TPP-binding site; other site 881621004075 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621004076 PYR/PP interface [polypeptide binding]; other site 881621004077 dimer interface [polypeptide binding]; other site 881621004078 TPP binding site [chemical binding]; other site 881621004079 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621004080 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 881621004081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004082 RNA binding surface [nucleotide binding]; other site 881621004083 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 881621004084 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 881621004085 arginine repressor; Provisional; Region: PRK04280 881621004086 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 881621004087 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 881621004088 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 881621004089 Walker A/P-loop; other site 881621004090 ATP binding site [chemical binding]; other site 881621004091 Q-loop/lid; other site 881621004092 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 881621004093 ABC transporter signature motif; other site 881621004094 Walker B; other site 881621004095 D-loop; other site 881621004096 H-loop/switch region; other site 881621004097 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 881621004098 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621004099 nucleotide binding site [chemical binding]; other site 881621004100 Acetokinase family; Region: Acetate_kinase; cl17229 881621004101 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 881621004102 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 881621004103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621004104 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621004105 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 881621004106 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621004107 tetramer interface [polypeptide binding]; other site 881621004108 TPP-binding site [chemical binding]; other site 881621004109 heterodimer interface [polypeptide binding]; other site 881621004110 phosphorylation loop region [posttranslational modification] 881621004111 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621004112 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621004113 alpha subunit interface [polypeptide binding]; other site 881621004114 TPP binding site [chemical binding]; other site 881621004115 heterodimer interface [polypeptide binding]; other site 881621004116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621004117 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 881621004118 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621004119 E3 interaction surface; other site 881621004120 lipoyl attachment site [posttranslational modification]; other site 881621004121 e3 binding domain; Region: E3_binding; pfam02817 881621004122 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 881621004123 peptidase T-like protein; Region: PepT-like; TIGR01883 881621004124 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 881621004125 metal binding site [ion binding]; metal-binding site 881621004126 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 881621004127 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 881621004128 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 881621004129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621004130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621004131 active site 881621004132 phosphorylation site [posttranslational modification] 881621004133 intermolecular recognition site; other site 881621004134 dimerization interface [polypeptide binding]; other site 881621004135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621004136 DNA binding site [nucleotide binding] 881621004137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 881621004138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621004139 dimerization interface [polypeptide binding]; other site 881621004140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621004141 dimer interface [polypeptide binding]; other site 881621004142 phosphorylation site [posttranslational modification] 881621004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004144 ATP binding site [chemical binding]; other site 881621004145 Mg2+ binding site [ion binding]; other site 881621004146 G-X-G motif; other site 881621004147 OxaA-like protein precursor; Validated; Region: PRK01622 881621004148 Acylphosphatase; Region: Acylphosphatase; cl00551 881621004149 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 881621004150 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 881621004151 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 881621004152 homotetramer interface [polypeptide binding]; other site 881621004153 FMN binding site [chemical binding]; other site 881621004154 homodimer contacts [polypeptide binding]; other site 881621004155 putative active site [active] 881621004156 putative substrate binding site [chemical binding]; other site 881621004157 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 881621004158 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 881621004159 active site residue [active] 881621004160 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 881621004161 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621004162 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621004163 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621004164 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 881621004165 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 881621004166 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 881621004167 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 881621004168 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 881621004169 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 881621004170 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 881621004171 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 881621004172 ligand binding site [chemical binding]; other site 881621004173 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 881621004174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621004175 Walker A/P-loop; other site 881621004176 ATP binding site [chemical binding]; other site 881621004177 Q-loop/lid; other site 881621004178 ABC transporter signature motif; other site 881621004179 Walker B; other site 881621004180 D-loop; other site 881621004181 H-loop/switch region; other site 881621004182 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 881621004183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 881621004184 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621004185 TM-ABC transporter signature motif; other site 881621004186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 881621004187 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621004188 TM-ABC transporter signature motif; other site 881621004189 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621004190 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621004191 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621004192 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 881621004193 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621004194 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 881621004195 classical (c) SDRs; Region: SDR_c; cd05233 881621004196 NAD(P) binding site [chemical binding]; other site 881621004197 active site 881621004198 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 881621004199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621004200 non-specific DNA binding site [nucleotide binding]; other site 881621004201 salt bridge; other site 881621004202 sequence-specific DNA binding site [nucleotide binding]; other site 881621004203 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 881621004204 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 881621004205 competence damage-inducible protein A; Provisional; Region: PRK00549 881621004206 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 881621004207 putative MPT binding site; other site 881621004208 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 881621004209 recombinase A; Provisional; Region: recA; PRK09354 881621004210 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 881621004211 hexamer interface [polypeptide binding]; other site 881621004212 Walker A motif; other site 881621004213 ATP binding site [chemical binding]; other site 881621004214 Walker B motif; other site 881621004215 phosphodiesterase; Provisional; Region: PRK12704 881621004216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004217 Zn2+ binding site [ion binding]; other site 881621004218 Mg2+ binding site [ion binding]; other site 881621004219 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621004220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621004221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 881621004222 Coenzyme A binding pocket [chemical binding]; other site 881621004223 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 881621004224 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621004225 putative active site [active] 881621004226 metal binding site [ion binding]; metal-binding site 881621004227 homodimer binding site [polypeptide binding]; other site 881621004228 Predicted membrane protein [Function unknown]; Region: COG4550 881621004229 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 881621004230 MutS domain I; Region: MutS_I; pfam01624 881621004231 MutS domain II; Region: MutS_II; pfam05188 881621004232 MutS domain III; Region: MutS_III; pfam05192 881621004233 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 881621004234 Walker A/P-loop; other site 881621004235 ATP binding site [chemical binding]; other site 881621004236 Q-loop/lid; other site 881621004237 ABC transporter signature motif; other site 881621004238 Walker B; other site 881621004239 D-loop; other site 881621004240 H-loop/switch region; other site 881621004241 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 881621004242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004243 ATP binding site [chemical binding]; other site 881621004244 Mg2+ binding site [ion binding]; other site 881621004245 G-X-G motif; other site 881621004246 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 881621004247 ATP binding site [chemical binding]; other site 881621004248 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 881621004249 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 881621004250 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621004251 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621004252 coenzyme A binding site [chemical binding]; other site 881621004253 active site 881621004254 catalytic residues [active] 881621004255 glycine loop; other site 881621004256 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 881621004257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621004258 FeS/SAM binding site; other site 881621004259 Predicted transcriptional regulators [Transcription]; Region: COG1695 881621004260 Transcriptional regulator PadR-like family; Region: PadR; cl17335 881621004261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621004263 putative substrate translocation pore; other site 881621004264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621004265 non-specific DNA binding site [nucleotide binding]; other site 881621004266 salt bridge; other site 881621004267 sequence-specific DNA binding site [nucleotide binding]; other site 881621004268 similar to integrase/recombinase, C-terminal part 881621004269 similar to integrase/recombinase, N-terminal part 881621004270 Similar to transcriptional regulator, N-terminal part 881621004271 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 881621004272 partial, C-terminal part 881621004273 Putative peptidoglycan linked protein (LPXTG motif), c-terminal part 881621004274 Putative peptidoglycan linked protein (LPXTG motif), n-terminal part 881621004275 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004276 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004277 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621004278 putative acyltransferase; Provisional; Region: PRK05790 881621004279 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 881621004280 dimer interface [polypeptide binding]; other site 881621004281 active site 881621004282 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 881621004283 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 881621004284 dimer interface [polypeptide binding]; other site 881621004285 active site 881621004286 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 881621004287 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 881621004288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004289 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 881621004290 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 881621004291 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621004292 Domain of unknown function DUF20; Region: UPF0118; pfam01594 881621004293 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 881621004294 FAD binding domain; Region: FAD_binding_4; pfam01565 881621004295 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 881621004296 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 881621004297 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 881621004298 Walker A/P-loop; other site 881621004299 ATP binding site [chemical binding]; other site 881621004300 Q-loop/lid; other site 881621004301 ABC transporter signature motif; other site 881621004302 Walker B; other site 881621004303 D-loop; other site 881621004304 H-loop/switch region; other site 881621004305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004306 dimer interface [polypeptide binding]; other site 881621004307 conserved gate region; other site 881621004308 ABC-ATPase subunit interface; other site 881621004309 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 881621004310 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 881621004311 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 881621004312 manganese transport protein MntH; Reviewed; Region: PRK00701 881621004313 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 881621004314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004315 dimer interface [polypeptide binding]; other site 881621004316 conserved gate region; other site 881621004317 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 881621004318 ABC-ATPase subunit interface; other site 881621004319 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 881621004320 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 881621004321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621004322 dimer interface [polypeptide binding]; other site 881621004323 conserved gate region; other site 881621004324 putative PBP binding loops; other site 881621004325 ABC-ATPase subunit interface; other site 881621004326 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 881621004327 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 881621004328 Walker A/P-loop; other site 881621004329 ATP binding site [chemical binding]; other site 881621004330 Q-loop/lid; other site 881621004331 ABC transporter signature motif; other site 881621004332 Walker B; other site 881621004333 D-loop; other site 881621004334 H-loop/switch region; other site 881621004335 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 881621004336 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 881621004337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 881621004338 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 881621004339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621004340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621004341 ABC transporter; Region: ABC_tran_2; pfam12848 881621004342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621004343 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 881621004344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621004345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621004346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621004347 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621004348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 881621004349 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621004350 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 881621004351 dihydrodipicolinate synthase; Region: dapA; TIGR00674 881621004352 dimer interface [polypeptide binding]; other site 881621004353 active site 881621004354 catalytic residue [active] 881621004355 aspartate kinase I; Reviewed; Region: PRK08210 881621004356 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 881621004357 nucleotide binding site [chemical binding]; other site 881621004358 substrate binding site [chemical binding]; other site 881621004359 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 881621004360 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621004361 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 881621004362 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 881621004363 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621004364 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621004365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 881621004366 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 881621004367 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 881621004368 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 881621004369 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 881621004370 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 881621004371 Predicted membrane protein [Function unknown]; Region: COG4392 881621004372 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 881621004373 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 881621004374 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621004375 metal binding site 2 [ion binding]; metal-binding site 881621004376 putative DNA binding helix; other site 881621004377 metal binding site 1 [ion binding]; metal-binding site 881621004378 dimer interface [polypeptide binding]; other site 881621004379 structural Zn2+ binding site [ion binding]; other site 881621004380 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 881621004381 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621004382 ABC-ATPase subunit interface; other site 881621004383 dimer interface [polypeptide binding]; other site 881621004384 putative PBP binding regions; other site 881621004385 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621004386 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 881621004387 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 881621004388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 881621004389 DHHA2 domain; Region: DHHA2; pfam02833 881621004390 endonuclease IV; Provisional; Region: PRK01060 881621004391 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 881621004392 AP (apurinic/apyrimidinic) site pocket; other site 881621004393 DNA interaction; other site 881621004394 Metal-binding active site; metal-binding site 881621004395 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 881621004396 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621004397 ATP binding site [chemical binding]; other site 881621004398 Mg++ binding site [ion binding]; other site 881621004399 motif III; other site 881621004400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621004401 nucleotide binding region [chemical binding]; other site 881621004402 ATP-binding site [chemical binding]; other site 881621004403 Uncharacterized conserved protein [Function unknown]; Region: COG0327 881621004404 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 881621004405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 881621004406 Uncharacterized conserved protein [Function unknown]; Region: COG0327 881621004407 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 881621004408 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 881621004409 Family of unknown function (DUF633); Region: DUF633; pfam04816 881621004410 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 881621004411 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 881621004412 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 881621004413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621004414 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621004415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621004416 DNA binding residues [nucleotide binding] 881621004417 DNA primase; Validated; Region: dnaG; PRK05667 881621004418 CHC2 zinc finger; Region: zf-CHC2; pfam01807 881621004419 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 881621004420 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 881621004421 active site 881621004422 metal binding site [ion binding]; metal-binding site 881621004423 interdomain interaction site; other site 881621004424 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 881621004425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 881621004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 881621004427 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 881621004428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 881621004429 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 881621004430 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 881621004431 dimer interface [polypeptide binding]; other site 881621004432 motif 1; other site 881621004433 active site 881621004434 motif 2; other site 881621004435 motif 3; other site 881621004436 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 881621004437 Recombination protein O N terminal; Region: RecO_N; pfam11967 881621004438 Recombination protein O C terminal; Region: RecO_C; pfam02565 881621004439 GTPase Era; Reviewed; Region: era; PRK00089 881621004440 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 881621004441 G1 box; other site 881621004442 GTP/Mg2+ binding site [chemical binding]; other site 881621004443 Switch I region; other site 881621004444 G2 box; other site 881621004445 Switch II region; other site 881621004446 G3 box; other site 881621004447 G4 box; other site 881621004448 G5 box; other site 881621004449 KH domain; Region: KH_2; pfam07650 881621004450 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 881621004451 active site 881621004452 catalytic motif [active] 881621004453 Zn binding site [ion binding]; other site 881621004454 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 881621004455 metal-binding heat shock protein; Provisional; Region: PRK00016 881621004456 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 881621004457 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 881621004458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004459 Zn2+ binding site [ion binding]; other site 881621004460 Mg2+ binding site [ion binding]; other site 881621004461 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 881621004462 PhoH-like protein; Region: PhoH; pfam02562 881621004463 Yqey-like protein; Region: YqeY; pfam09424 881621004464 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 881621004465 RNA methyltransferase, RsmE family; Region: TIGR00046 881621004466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 881621004467 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 881621004468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004469 S-adenosylmethionine binding site [chemical binding]; other site 881621004470 chaperone protein DnaJ; Provisional; Region: PRK14280 881621004471 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 881621004472 HSP70 interaction site [polypeptide binding]; other site 881621004473 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 881621004474 substrate binding site [polypeptide binding]; other site 881621004475 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 881621004476 Zn binding sites [ion binding]; other site 881621004477 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 881621004478 dimer interface [polypeptide binding]; other site 881621004479 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 881621004480 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 881621004481 nucleotide binding site [chemical binding]; other site 881621004482 NEF interaction site [polypeptide binding]; other site 881621004483 SBD interface [polypeptide binding]; other site 881621004484 heat shock protein GrpE; Provisional; Region: PRK14140 881621004485 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 881621004486 dimer interface [polypeptide binding]; other site 881621004487 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 881621004488 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 881621004489 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 881621004490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621004491 FeS/SAM binding site; other site 881621004492 HemN C-terminal domain; Region: HemN_C; pfam06969 881621004493 similal to oxidoreductase, partial 881621004494 similal to oxidoreductase, partial 881621004495 GTP-binding protein LepA; Provisional; Region: PRK05433 881621004496 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 881621004497 G1 box; other site 881621004498 putative GEF interaction site [polypeptide binding]; other site 881621004499 GTP/Mg2+ binding site [chemical binding]; other site 881621004500 Switch I region; other site 881621004501 G2 box; other site 881621004502 G3 box; other site 881621004503 Switch II region; other site 881621004504 G4 box; other site 881621004505 G5 box; other site 881621004506 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 881621004507 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 881621004508 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 881621004509 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 881621004510 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 881621004511 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 881621004512 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,C-terminal part 881621004513 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,N-terminal part 881621004514 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 881621004515 catalytic motif [active] 881621004516 Zn binding site [ion binding]; other site 881621004517 SLBB domain; Region: SLBB; pfam10531 881621004518 comEA protein; Region: comE; TIGR01259 881621004519 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 881621004520 Methyltransferase domain; Region: Methyltransf_23; pfam13489 881621004521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004522 S-adenosylmethionine binding site [chemical binding]; other site 881621004523 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 881621004524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004525 Zn2+ binding site [ion binding]; other site 881621004526 Mg2+ binding site [ion binding]; other site 881621004527 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 881621004528 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 881621004529 active site 881621004530 (T/H)XGH motif; other site 881621004531 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 881621004532 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 881621004533 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621004534 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621004535 shikimate binding site; other site 881621004536 NAD(P) binding site [chemical binding]; other site 881621004537 GTPase YqeH; Provisional; Region: PRK13796 881621004538 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 881621004539 GTP/Mg2+ binding site [chemical binding]; other site 881621004540 G4 box; other site 881621004541 G5 box; other site 881621004542 G1 box; other site 881621004543 Switch I region; other site 881621004544 G2 box; other site 881621004545 G3 box; other site 881621004546 Switch II region; other site 881621004547 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 881621004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621004549 motif II; other site 881621004550 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 881621004551 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 881621004552 active site 881621004553 Zn binding site [ion binding]; other site 881621004554 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 881621004555 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 881621004556 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 881621004557 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 881621004558 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 881621004559 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 881621004560 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 881621004561 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 881621004562 Sugar specificity; other site 881621004563 Pyrimidine base specificity; other site 881621004564 ATP-binding site [chemical binding]; other site 881621004565 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 881621004566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621004567 S-adenosylmethionine binding site [chemical binding]; other site 881621004568 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 881621004569 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 881621004570 dimerization interface [polypeptide binding]; other site 881621004571 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 881621004572 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 881621004573 hypothetical protein; Provisional; Region: PRK13678 881621004574 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 881621004575 hypothetical protein; Provisional; Region: PRK05473 881621004576 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 881621004577 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 881621004578 motif 1; other site 881621004579 active site 881621004580 motif 2; other site 881621004581 motif 3; other site 881621004582 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 881621004583 DHHA1 domain; Region: DHHA1; pfam02272 881621004584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621004585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621004586 Walker A/P-loop; other site 881621004587 ATP binding site [chemical binding]; other site 881621004588 Q-loop/lid; other site 881621004589 ABC transporter signature motif; other site 881621004590 Walker B; other site 881621004591 D-loop; other site 881621004592 H-loop/switch region; other site 881621004593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621004594 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621004595 FtsX-like permease family; Region: FtsX; pfam02687 881621004596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621004597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621004598 active site 881621004599 phosphorylation site [posttranslational modification] 881621004600 intermolecular recognition site; other site 881621004601 dimerization interface [polypeptide binding]; other site 881621004602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621004603 DNA binding site [nucleotide binding] 881621004604 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 881621004605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621004606 dimerization interface [polypeptide binding]; other site 881621004607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621004608 dimer interface [polypeptide binding]; other site 881621004609 phosphorylation site [posttranslational modification] 881621004610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004611 ATP binding site [chemical binding]; other site 881621004612 Mg2+ binding site [ion binding]; other site 881621004613 G-X-G motif; other site 881621004614 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 881621004615 AAA domain; Region: AAA_30; pfam13604 881621004616 Family description; Region: UvrD_C_2; pfam13538 881621004617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621004618 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 881621004619 TPR motif; other site 881621004620 binding surface 881621004621 TPR repeat; Region: TPR_11; pfam13414 881621004622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621004623 binding surface 881621004624 TPR motif; other site 881621004625 TPR repeat; Region: TPR_11; pfam13414 881621004626 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621004627 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 881621004628 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 881621004629 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 881621004630 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 881621004631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004632 catalytic residue [active] 881621004633 recombination factor protein RarA; Reviewed; Region: PRK13342 881621004634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004635 Walker A motif; other site 881621004636 ATP binding site [chemical binding]; other site 881621004637 Walker B motif; other site 881621004638 arginine finger; other site 881621004639 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 881621004640 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621004641 Transcriptional regulator; Region: Rrf2; pfam02082 881621004642 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 881621004643 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 881621004644 Nitrogen regulatory protein P-II; Region: P-II; smart00938 881621004645 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 881621004646 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 881621004647 dimer interface [polypeptide binding]; other site 881621004648 anticodon binding site; other site 881621004649 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 881621004650 homodimer interface [polypeptide binding]; other site 881621004651 motif 1; other site 881621004652 active site 881621004653 motif 2; other site 881621004654 GAD domain; Region: GAD; pfam02938 881621004655 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 881621004656 active site 881621004657 motif 3; other site 881621004658 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 881621004659 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 881621004660 dimer interface [polypeptide binding]; other site 881621004661 motif 1; other site 881621004662 active site 881621004663 motif 2; other site 881621004664 motif 3; other site 881621004665 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 881621004666 anticodon binding site; other site 881621004667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 881621004668 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621004669 Bacterial SH3 domain; Region: SH3_3; pfam08239 881621004670 Bacterial SH3 domain homologues; Region: SH3b; smart00287 881621004671 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 881621004672 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 881621004673 active site 881621004674 metal binding site [ion binding]; metal-binding site 881621004675 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 881621004676 putative active site [active] 881621004677 dimerization interface [polypeptide binding]; other site 881621004678 putative tRNAtyr binding site [nucleotide binding]; other site 881621004679 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 881621004680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004681 Zn2+ binding site [ion binding]; other site 881621004682 Mg2+ binding site [ion binding]; other site 881621004683 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621004684 synthetase active site [active] 881621004685 NTP binding site [chemical binding]; other site 881621004686 metal binding site [ion binding]; metal-binding site 881621004687 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 881621004688 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 881621004689 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621004690 active site 881621004691 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 881621004692 DHH family; Region: DHH; pfam01368 881621004693 DHHA1 domain; Region: DHHA1; pfam02272 881621004694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 881621004695 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 881621004696 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 881621004697 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 881621004698 Protein export membrane protein; Region: SecD_SecF; cl14618 881621004699 Protein export membrane protein; Region: SecD_SecF; pfam02355 881621004700 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 881621004701 Preprotein translocase subunit; Region: YajC; pfam02699 881621004702 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 881621004703 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 881621004704 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 881621004705 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 881621004706 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 881621004707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004708 Walker A motif; other site 881621004709 ATP binding site [chemical binding]; other site 881621004710 Walker B motif; other site 881621004711 arginine finger; other site 881621004712 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 881621004713 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 881621004714 RuvA N terminal domain; Region: RuvA_N; pfam01330 881621004715 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 881621004716 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621004717 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621004718 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621004719 NAD binding site [chemical binding]; other site 881621004720 dimer interface [polypeptide binding]; other site 881621004721 substrate binding site [chemical binding]; other site 881621004722 hypothetical protein; Validated; Region: PRK00110 881621004723 prephenate dehydratase; Provisional; Region: PRK11898 881621004724 Prephenate dehydratase; Region: PDT; pfam00800 881621004725 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 881621004726 putative L-Phe binding site [chemical binding]; other site 881621004727 GTPase CgtA; Reviewed; Region: obgE; PRK12297 881621004728 GTP1/OBG; Region: GTP1_OBG; pfam01018 881621004729 Obg GTPase; Region: Obg; cd01898 881621004730 G1 box; other site 881621004731 GTP/Mg2+ binding site [chemical binding]; other site 881621004732 Switch I region; other site 881621004733 G2 box; other site 881621004734 G3 box; other site 881621004735 Switch II region; other site 881621004736 G4 box; other site 881621004737 G5 box; other site 881621004738 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 881621004739 glycerol kinase; Provisional; Region: glpK; PRK00047 881621004740 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 881621004741 N- and C-terminal domain interface [polypeptide binding]; other site 881621004742 active site 881621004743 MgATP binding site [chemical binding]; other site 881621004744 catalytic site [active] 881621004745 metal binding site [ion binding]; metal-binding site 881621004746 glycerol binding site [chemical binding]; other site 881621004747 homotetramer interface [polypeptide binding]; other site 881621004748 homodimer interface [polypeptide binding]; other site 881621004749 FBP binding site [chemical binding]; other site 881621004750 protein IIAGlc interface [polypeptide binding]; other site 881621004751 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 881621004752 amphipathic channel; other site 881621004753 Asn-Pro-Ala signature motifs; other site 881621004754 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 881621004755 hypothetical protein; Provisional; Region: PRK14553 881621004756 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 881621004757 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 881621004758 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 881621004759 homodimer interface [polypeptide binding]; other site 881621004760 oligonucleotide binding site [chemical binding]; other site 881621004761 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 881621004762 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 881621004763 Switch I; other site 881621004764 Switch II; other site 881621004765 septum formation inhibitor; Reviewed; Region: minC; PRK00513 881621004766 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 881621004767 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 881621004768 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 881621004769 rod shape-determining protein MreC; Region: MreC; pfam04085 881621004770 rod shape-determining protein MreB; Provisional; Region: PRK13927 881621004771 MreB and similar proteins; Region: MreB_like; cd10225 881621004772 nucleotide binding site [chemical binding]; other site 881621004773 Mg binding site [ion binding]; other site 881621004774 putative protofilament interaction site [polypeptide binding]; other site 881621004775 RodZ interaction site [polypeptide binding]; other site 881621004776 hypothetical protein; Reviewed; Region: PRK00024 881621004777 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 881621004778 MPN+ (JAMM) motif; other site 881621004779 Zinc-binding site [ion binding]; other site 881621004780 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 881621004781 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 881621004782 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 881621004783 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 881621004784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621004785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621004786 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 881621004787 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 881621004788 active site 881621004789 HIGH motif; other site 881621004790 nucleotide binding site [chemical binding]; other site 881621004791 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 881621004792 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 881621004793 active site 881621004794 KMSKS motif; other site 881621004795 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 881621004796 tRNA binding surface [nucleotide binding]; other site 881621004797 anticodon binding site; other site 881621004798 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 881621004799 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 881621004800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621004801 inhibitor-cofactor binding pocket; inhibition site 881621004802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004803 catalytic residue [active] 881621004804 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 881621004805 dimer interface [polypeptide binding]; other site 881621004806 active site 881621004807 Schiff base residues; other site 881621004808 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 881621004809 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 881621004810 active site 881621004811 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 881621004812 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 881621004813 domain interfaces; other site 881621004814 active site 881621004815 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 881621004816 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 881621004817 tRNA; other site 881621004818 putative tRNA binding site [nucleotide binding]; other site 881621004819 putative NADP binding site [chemical binding]; other site 881621004820 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 881621004821 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 881621004822 G1 box; other site 881621004823 GTP/Mg2+ binding site [chemical binding]; other site 881621004824 Switch I region; other site 881621004825 G2 box; other site 881621004826 G3 box; other site 881621004827 Switch II region; other site 881621004828 G4 box; other site 881621004829 G5 box; other site 881621004830 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 881621004831 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 881621004832 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 881621004833 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 881621004834 active site 881621004835 dimer interface [polypeptide binding]; other site 881621004836 motif 1; other site 881621004837 motif 2; other site 881621004838 motif 3; other site 881621004839 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 881621004840 anticodon binding site; other site 881621004841 primosomal protein DnaI; Reviewed; Region: PRK08939 881621004842 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 881621004843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621004844 Walker A motif; other site 881621004845 ATP binding site [chemical binding]; other site 881621004846 Walker B motif; other site 881621004847 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 881621004848 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 881621004849 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 881621004850 ATP cone domain; Region: ATP-cone; pfam03477 881621004851 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 881621004852 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 881621004853 CoA-binding site [chemical binding]; other site 881621004854 ATP-binding [chemical binding]; other site 881621004855 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 881621004856 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 881621004857 DNA binding site [nucleotide binding] 881621004858 catalytic residue [active] 881621004859 H2TH interface [polypeptide binding]; other site 881621004860 putative catalytic residues [active] 881621004861 turnover-facilitating residue; other site 881621004862 intercalation triad [nucleotide binding]; other site 881621004863 8OG recognition residue [nucleotide binding]; other site 881621004864 putative reading head residues; other site 881621004865 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 881621004866 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621004867 DNA polymerase I; Provisional; Region: PRK05755 881621004868 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621004869 active site 881621004870 metal binding site 1 [ion binding]; metal-binding site 881621004871 putative 5' ssDNA interaction site; other site 881621004872 metal binding site 3; metal-binding site 881621004873 metal binding site 2 [ion binding]; metal-binding site 881621004874 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621004875 putative DNA binding site [nucleotide binding]; other site 881621004876 putative metal binding site [ion binding]; other site 881621004877 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 881621004878 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 881621004879 active site 881621004880 DNA binding site [nucleotide binding] 881621004881 catalytic site [active] 881621004882 isocitrate dehydrogenase; Reviewed; Region: PRK07006 881621004883 isocitrate dehydrogenase; Validated; Region: PRK07362 881621004884 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 881621004885 dimer interface [polypeptide binding]; other site 881621004886 Citrate synthase; Region: Citrate_synt; pfam00285 881621004887 active site 881621004888 citrylCoA binding site [chemical binding]; other site 881621004889 oxalacetate/citrate binding site [chemical binding]; other site 881621004890 coenzyme A binding site [chemical binding]; other site 881621004891 catalytic triad [active] 881621004892 Protein of unknown function (DUF441); Region: DUF441; pfam04284 881621004893 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 881621004894 pyruvate kinase; Provisional; Region: PRK06354 881621004895 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 881621004896 domain interfaces; other site 881621004897 active site 881621004898 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 881621004899 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 881621004900 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 881621004901 active site 881621004902 ADP/pyrophosphate binding site [chemical binding]; other site 881621004903 dimerization interface [polypeptide binding]; other site 881621004904 allosteric effector site; other site 881621004905 fructose-1,6-bisphosphate binding site; other site 881621004906 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 881621004907 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 881621004908 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 881621004909 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 881621004910 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 881621004911 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 881621004912 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 881621004913 active site 881621004914 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 881621004915 generic binding surface I; other site 881621004916 generic binding surface II; other site 881621004917 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 881621004918 DHH family; Region: DHH; pfam01368 881621004919 DHHA1 domain; Region: DHHA1; pfam02272 881621004920 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 881621004921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 881621004922 DNA-binding site [nucleotide binding]; DNA binding site 881621004923 DRTGG domain; Region: DRTGG; pfam07085 881621004924 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 881621004925 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 881621004926 active site 2 [active] 881621004927 active site 1 [active] 881621004928 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 881621004929 metal-dependent hydrolase; Provisional; Region: PRK00685 881621004930 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621004931 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621004932 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621004933 active site 881621004934 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 881621004935 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 881621004936 hexamer interface [polypeptide binding]; other site 881621004937 ligand binding site [chemical binding]; other site 881621004938 putative active site [active] 881621004939 NAD(P) binding site [chemical binding]; other site 881621004940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621004941 Ligand Binding Site [chemical binding]; other site 881621004942 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 881621004943 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 881621004944 substrate binding pocket [chemical binding]; other site 881621004945 catalytic triad [active] 881621004946 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 881621004947 propionate/acetate kinase; Provisional; Region: PRK12379 881621004948 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 881621004949 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 881621004950 dimer interface [polypeptide binding]; other site 881621004951 catalytic triad [active] 881621004952 peroxidatic and resolving cysteines [active] 881621004953 RDD family; Region: RDD; pfam06271 881621004954 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 881621004955 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 881621004956 tandem repeat interface [polypeptide binding]; other site 881621004957 oligomer interface [polypeptide binding]; other site 881621004958 active site residues [active] 881621004959 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 881621004960 ATP-NAD kinase; Region: NAD_kinase; pfam01513 881621004961 ornithine carbamoyltransferase; Provisional; Region: PRK00779 881621004962 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621004963 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 881621004964 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 881621004965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621004966 inhibitor-cofactor binding pocket; inhibition site 881621004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004968 catalytic residue [active] 881621004969 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 881621004970 nucleotide binding site [chemical binding]; other site 881621004971 N-acetyl-L-glutamate binding site [chemical binding]; other site 881621004972 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 881621004973 heterotetramer interface [polypeptide binding]; other site 881621004974 active site pocket [active] 881621004975 cleavage site 881621004976 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 881621004977 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 881621004978 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 881621004979 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 881621004980 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 881621004981 Ligand Binding Site [chemical binding]; other site 881621004982 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 881621004983 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 881621004984 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004985 catalytic residue [active] 881621004986 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 881621004987 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 881621004988 GAF domain; Region: GAF_2; pfam13185 881621004989 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 881621004990 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 881621004991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004992 RNA binding surface [nucleotide binding]; other site 881621004993 truncated, N-terminal part 881621004994 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 881621004995 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 881621004996 active site 881621004997 HIGH motif; other site 881621004998 dimer interface [polypeptide binding]; other site 881621004999 KMSKS motif; other site 881621005000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621005001 RNA binding surface [nucleotide binding]; other site 881621005002 catabolite control protein A; Region: ccpA; TIGR01481 881621005003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621005004 DNA binding site [nucleotide binding] 881621005005 domain linker motif; other site 881621005006 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 881621005007 dimerization interface [polypeptide binding]; other site 881621005008 effector binding site; other site 881621005009 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 881621005010 Chorismate mutase type II; Region: CM_2; cl00693 881621005011 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 881621005012 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 881621005013 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 881621005014 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 881621005015 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 881621005016 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 881621005017 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 881621005018 dimer interface [polypeptide binding]; other site 881621005019 decamer (pentamer of dimers) interface [polypeptide binding]; other site 881621005020 catalytic triad [active] 881621005021 peroxidatic and resolving cysteines [active] 881621005022 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 881621005023 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621005024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621005025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621005026 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 881621005027 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 881621005028 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 881621005029 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 881621005030 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621005031 putative tRNA-binding site [nucleotide binding]; other site 881621005032 hypothetical protein; Provisional; Region: PRK13668 881621005033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621005034 catalytic residues [active] 881621005035 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 881621005036 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621005037 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621005038 oligomer interface [polypeptide binding]; other site 881621005039 active site 881621005040 metal binding site [ion binding]; metal-binding site 881621005041 Predicted small secreted protein [Function unknown]; Region: COG5584 881621005042 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621005043 methionine cluster; other site 881621005044 active site 881621005045 phosphorylation site [posttranslational modification] 881621005046 metal binding site [ion binding]; metal-binding site 881621005047 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621005048 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 881621005049 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 881621005050 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621005051 active site 881621005052 P-loop; other site 881621005053 phosphorylation site [posttranslational modification] 881621005054 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621005055 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 881621005056 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621005057 HTH domain; Region: HTH_11; pfam08279 881621005058 Mga helix-turn-helix domain; Region: Mga; pfam05043 881621005059 PRD domain; Region: PRD; pfam00874 881621005060 PRD domain; Region: PRD; pfam00874 881621005061 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621005062 active site 881621005063 P-loop; other site 881621005064 phosphorylation site [posttranslational modification] 881621005065 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621005066 active site 881621005067 phosphorylation site [posttranslational modification] 881621005068 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621005069 putative homodimer interface [polypeptide binding]; other site 881621005070 putative homotetramer interface [polypeptide binding]; other site 881621005071 putative allosteric switch controlling residues; other site 881621005072 putative metal binding site [ion binding]; other site 881621005073 putative homodimer-homodimer interface [polypeptide binding]; other site 881621005074 similar to unknown protein, C-terminal part 881621005075 similar to unknown protein, N-terminal part 881621005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005077 S-adenosylmethionine binding site [chemical binding]; other site 881621005078 Phosphotransferase enzyme family; Region: APH; pfam01636 881621005079 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 881621005080 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621005081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005082 putative substrate translocation pore; other site 881621005083 MarR family; Region: MarR; pfam01047 881621005084 MarR family; Region: MarR_2; cl17246 881621005085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 881621005086 MULE transposase domain; Region: MULE; pfam10551 881621005087 similar to unknown protein 881621005088 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 881621005089 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 881621005090 homodimer interface [polypeptide binding]; other site 881621005091 substrate-cofactor binding pocket; other site 881621005092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005093 catalytic residue [active] 881621005094 dipeptidase PepV; Reviewed; Region: PRK07318 881621005095 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 881621005096 active site 881621005097 metal binding site [ion binding]; metal-binding site 881621005098 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 881621005099 nudix motif; other site 881621005100 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 881621005101 putative substrate binding site [chemical binding]; other site 881621005102 putative ATP binding site [chemical binding]; other site 881621005103 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621005104 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 881621005105 active site 881621005106 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 881621005107 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 881621005108 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 881621005109 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 881621005110 substrate binding site [chemical binding]; other site 881621005111 active site 881621005112 catalytic residues [active] 881621005113 heterodimer interface [polypeptide binding]; other site 881621005114 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 881621005115 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 881621005116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005117 catalytic residue [active] 881621005118 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 881621005119 active site 881621005120 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 881621005121 active site 881621005122 ribulose/triose binding site [chemical binding]; other site 881621005123 phosphate binding site [ion binding]; other site 881621005124 substrate (anthranilate) binding pocket [chemical binding]; other site 881621005125 product (indole) binding pocket [chemical binding]; other site 881621005126 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 881621005127 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621005128 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621005129 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621005130 Glutamine amidotransferase class-I; Region: GATase; pfam00117 881621005131 glutamine binding [chemical binding]; other site 881621005132 catalytic triad [active] 881621005133 anthranilate synthase component I; Provisional; Region: PRK13570 881621005134 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 881621005135 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 881621005136 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 881621005137 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621005138 putative catalytic cysteine [active] 881621005139 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 881621005140 putative active site [active] 881621005141 metal binding site [ion binding]; metal-binding site 881621005142 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621005143 dimer interface [polypeptide binding]; other site 881621005144 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621005145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621005146 Walker A/P-loop; other site 881621005147 ATP binding site [chemical binding]; other site 881621005148 Q-loop/lid; other site 881621005149 ABC transporter signature motif; other site 881621005150 Walker B; other site 881621005151 D-loop; other site 881621005152 H-loop/switch region; other site 881621005153 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 881621005154 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 881621005155 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621005156 putative dimer interface [polypeptide binding]; other site 881621005157 catalytic triad [active] 881621005158 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 881621005159 aconitate hydratase; Validated; Region: PRK09277 881621005160 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 881621005161 substrate binding site [chemical binding]; other site 881621005162 ligand binding site [chemical binding]; other site 881621005163 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 881621005164 substrate binding site [chemical binding]; other site 881621005165 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621005166 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 881621005167 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 881621005168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005169 ATP binding site [chemical binding]; other site 881621005170 putative Mg++ binding site [ion binding]; other site 881621005171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005172 nucleotide binding region [chemical binding]; other site 881621005173 ATP-binding site [chemical binding]; other site 881621005174 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 881621005175 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 881621005176 Walker A/P-loop; other site 881621005177 ATP binding site [chemical binding]; other site 881621005178 Q-loop/lid; other site 881621005179 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 881621005180 ABC transporter signature motif; other site 881621005181 Walker B; other site 881621005182 D-loop; other site 881621005183 H-loop/switch region; other site 881621005184 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621005185 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621005186 active site 881621005187 metal binding site [ion binding]; metal-binding site 881621005188 DNA binding site [nucleotide binding] 881621005189 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 881621005190 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 881621005191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 881621005192 putative acyl-acceptor binding pocket; other site 881621005193 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 881621005194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621005195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621005196 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 881621005197 Walker A/P-loop; other site 881621005198 ATP binding site [chemical binding]; other site 881621005199 Q-loop/lid; other site 881621005200 ABC transporter signature motif; other site 881621005201 Walker B; other site 881621005202 D-loop; other site 881621005203 H-loop/switch region; other site 881621005204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621005205 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 881621005206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621005207 Walker A/P-loop; other site 881621005208 ATP binding site [chemical binding]; other site 881621005209 Q-loop/lid; other site 881621005210 ABC transporter signature motif; other site 881621005211 Walker B; other site 881621005212 D-loop; other site 881621005213 H-loop/switch region; other site 881621005214 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621005215 active site 881621005216 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621005217 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621005218 active site 881621005219 active site 881621005220 similar to peptidoglycan hydrolase (phage related),C-terminal part unknown 881621005221 similar to peptidoglycan hydrolase (phage related),internal part 881621005222 similar to peptidoglycan hydrolase (phage related),N-terminal part 881621005223 Small integral membrane protein [Function unknown]; Region: COG5546 881621005224 elongation factor Ts; Provisional; Region: tsf; PRK09377 881621005225 UBA/TS-N domain; Region: UBA; pfam00627 881621005226 Elongation factor TS; Region: EF_TS; pfam00889 881621005227 Elongation factor TS; Region: EF_TS; pfam00889 881621005228 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 881621005229 rRNA interaction site [nucleotide binding]; other site 881621005230 S8 interaction site; other site 881621005231 putative laminin-1 binding site; other site 881621005232 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 881621005233 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 881621005234 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 881621005235 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 881621005236 active site 881621005237 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621005238 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621005239 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621005240 putative active site [active] 881621005241 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 881621005242 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 881621005243 putative active site [active] 881621005244 Uncharacterized conserved protein [Function unknown]; Region: COG3589 881621005245 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 881621005246 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621005247 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621005248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 881621005249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621005250 Coenzyme A binding pocket [chemical binding]; other site 881621005251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 881621005252 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 881621005253 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 881621005254 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621005255 HIGH motif; other site 881621005256 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 881621005257 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621005258 active site 881621005259 KMSKS motif; other site 881621005260 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 881621005261 tRNA binding surface [nucleotide binding]; other site 881621005262 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 881621005263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 881621005264 FeS/SAM binding site; other site 881621005265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005266 S-adenosylmethionine binding site [chemical binding]; other site 881621005267 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 881621005268 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 881621005269 active site 881621005270 dimer interface [polypeptide binding]; other site 881621005271 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 881621005272 Ligand Binding Site [chemical binding]; other site 881621005273 Molecular Tunnel; other site 881621005274 S-adenosylmethionine synthetase; Validated; Region: PRK05250 881621005275 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 881621005276 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 881621005277 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 881621005278 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621005279 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621005280 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621005281 NAD binding site [chemical binding]; other site 881621005282 dimer interface [polypeptide binding]; other site 881621005283 substrate binding site [chemical binding]; other site 881621005284 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 881621005285 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 881621005286 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 881621005287 nudix motif; other site 881621005288 Haemolytic domain; Region: Haemolytic; pfam01809 881621005289 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 881621005290 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621005291 metal binding site [ion binding]; metal-binding site 881621005292 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 881621005293 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 881621005294 acyl-activating enzyme (AAE) consensus motif; other site 881621005295 putative AMP binding site [chemical binding]; other site 881621005296 putative active site [active] 881621005297 putative CoA binding site [chemical binding]; other site 881621005298 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 881621005299 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 881621005300 substrate binding site [chemical binding]; other site 881621005301 oxyanion hole (OAH) forming residues; other site 881621005302 trimer interface [polypeptide binding]; other site 881621005303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621005304 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 881621005305 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 881621005306 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 881621005307 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 881621005308 dimer interface [polypeptide binding]; other site 881621005309 tetramer interface [polypeptide binding]; other site 881621005310 PYR/PP interface [polypeptide binding]; other site 881621005311 TPP binding site [chemical binding]; other site 881621005312 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 881621005313 TPP-binding site; other site 881621005314 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 881621005315 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621005316 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 881621005317 UbiA prenyltransferase family; Region: UbiA; pfam01040 881621005318 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 881621005319 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 881621005320 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 881621005321 FAD binding site [chemical binding]; other site 881621005322 cystathionine beta-lyase; Provisional; Region: PRK08064 881621005323 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621005324 homodimer interface [polypeptide binding]; other site 881621005325 substrate-cofactor binding pocket; other site 881621005326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005327 catalytic residue [active] 881621005328 cystathionine gamma-synthase; Reviewed; Region: PRK08247 881621005329 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621005330 homodimer interface [polypeptide binding]; other site 881621005331 substrate-cofactor binding pocket; other site 881621005332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005333 catalytic residue [active] 881621005334 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 881621005335 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 881621005336 THF binding site; other site 881621005337 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 881621005338 substrate binding site [chemical binding]; other site 881621005339 THF binding site; other site 881621005340 zinc-binding site [ion binding]; other site 881621005341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621005343 putative substrate translocation pore; other site 881621005344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621005345 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621005346 metal binding site 2 [ion binding]; metal-binding site 881621005347 putative DNA binding helix; other site 881621005348 metal binding site 1 [ion binding]; metal-binding site 881621005349 dimer interface [polypeptide binding]; other site 881621005350 structural Zn2+ binding site [ion binding]; other site 881621005351 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 881621005352 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 881621005353 NAD binding site [chemical binding]; other site 881621005354 ligand binding site [chemical binding]; other site 881621005355 catalytic site [active] 881621005356 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 881621005357 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 881621005358 inhibitor-cofactor binding pocket; inhibition site 881621005359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005360 catalytic residue [active] 881621005361 Predicted membrane protein [Function unknown]; Region: COG4129 881621005362 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 881621005363 hypothetical protein; Provisional; Region: PRK13662 881621005364 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 881621005365 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 881621005366 putative NAD(P) binding site [chemical binding]; other site 881621005367 active site 881621005368 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 881621005369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621005370 minor groove reading motif; other site 881621005371 helix-hairpin-helix signature motif; other site 881621005372 substrate binding pocket [chemical binding]; other site 881621005373 active site 881621005374 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 881621005375 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 881621005376 DNA binding and oxoG recognition site [nucleotide binding] 881621005377 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 881621005378 Transposase domain (DUF772); Region: DUF772; pfam05598 881621005379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 881621005380 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 881621005381 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 881621005382 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 881621005383 trimer interface [polypeptide binding]; other site 881621005384 active site 881621005385 WVELL protein; Region: WVELL; pfam14043 881621005386 recombination regulator RecX; Provisional; Region: recX; PRK14135 881621005387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005388 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 881621005389 NAD(P) binding site [chemical binding]; other site 881621005390 active site 881621005391 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621005392 Uncharacterized conserved protein [Function unknown]; Region: COG2898 881621005393 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 881621005394 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 881621005395 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621005396 Cation efflux family; Region: Cation_efflux; pfam01545 881621005397 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621005398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 881621005399 PAS fold; Region: PAS_4; pfam08448 881621005400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621005401 putative active site [active] 881621005402 heme pocket [chemical binding]; other site 881621005403 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 881621005404 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 881621005405 dimer interface [polypeptide binding]; other site 881621005406 putative CheW interface [polypeptide binding]; other site 881621005407 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 881621005408 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621005409 active site 881621005410 metal binding site [ion binding]; metal-binding site 881621005411 TRAM domain; Region: TRAM; cl01282 881621005412 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 881621005413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005414 S-adenosylmethionine binding site [chemical binding]; other site 881621005415 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 881621005416 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 881621005417 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 881621005418 Substrate-binding site [chemical binding]; other site 881621005419 Substrate specificity [chemical binding]; other site 881621005420 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 881621005421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 881621005422 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 881621005423 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 881621005424 active site 881621005425 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 881621005426 flavodoxin, short chain; Region: flav_short; TIGR01753 881621005427 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 881621005428 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 881621005429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621005431 putative substrate translocation pore; other site 881621005432 rod-share determining protein MreBH; Provisional; Region: PRK13929 881621005433 MreB and similar proteins; Region: MreB_like; cd10225 881621005434 nucleotide binding site [chemical binding]; other site 881621005435 Mg binding site [ion binding]; other site 881621005436 putative protofilament interaction site [polypeptide binding]; other site 881621005437 RodZ interaction site [polypeptide binding]; other site 881621005438 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005439 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621005440 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005441 Substrate binding site [chemical binding]; other site 881621005442 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005443 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005444 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005445 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005446 Leucine rich repeat; Region: LRR_8; pfam13855 881621005447 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005448 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621005449 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005450 Leucine rich repeat; Region: LRR_8; pfam13855 881621005451 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005452 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005453 Uncharacterized conserved protein [Function unknown]; Region: COG4748 881621005454 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 881621005455 Uncharacterized conserved protein [Function unknown]; Region: COG3589 881621005456 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 881621005457 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621005458 methionine cluster; other site 881621005459 active site 881621005460 phosphorylation site [posttranslational modification] 881621005461 metal binding site [ion binding]; metal-binding site 881621005462 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621005463 active site 881621005464 P-loop; other site 881621005465 phosphorylation site [posttranslational modification] 881621005466 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621005467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621005468 Walker A motif; other site 881621005469 ATP binding site [chemical binding]; other site 881621005470 Walker B motif; other site 881621005471 arginine finger; other site 881621005472 Transcriptional antiterminator [Transcription]; Region: COG3933 881621005473 PRD domain; Region: PRD; pfam00874 881621005474 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621005475 active pocket/dimerization site; other site 881621005476 active site 881621005477 phosphorylation site [posttranslational modification] 881621005478 PRD domain; Region: PRD; pfam00874 881621005479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621005480 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 881621005481 ATP binding site [chemical binding]; other site 881621005482 putative Mg++ binding site [ion binding]; other site 881621005483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005484 nucleotide binding region [chemical binding]; other site 881621005485 ATP-binding site [chemical binding]; other site 881621005486 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 881621005487 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621005488 Walker A/P-loop; other site 881621005489 ATP binding site [chemical binding]; other site 881621005490 Q-loop/lid; other site 881621005491 ABC transporter signature motif; other site 881621005492 Walker B; other site 881621005493 D-loop; other site 881621005494 H-loop/switch region; other site 881621005495 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621005496 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621005497 DNA-binding site [nucleotide binding]; DNA binding site 881621005498 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005499 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621005500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621005501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621005502 DNA binding site [nucleotide binding] 881621005503 domain linker motif; other site 881621005504 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621005505 dimerization interface [polypeptide binding]; other site 881621005506 ligand binding site [chemical binding]; other site 881621005507 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 881621005508 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 881621005509 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621005510 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 881621005511 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 881621005512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621005513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621005514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005515 dimer interface [polypeptide binding]; other site 881621005516 conserved gate region; other site 881621005517 putative PBP binding loops; other site 881621005518 ABC-ATPase subunit interface; other site 881621005519 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621005520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005521 dimer interface [polypeptide binding]; other site 881621005522 conserved gate region; other site 881621005523 putative PBP binding loops; other site 881621005524 ABC-ATPase subunit interface; other site 881621005525 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 881621005526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 881621005527 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 881621005528 NAD(P) binding pocket [chemical binding]; other site 881621005529 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 881621005530 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 881621005531 active site 881621005532 dimer interface [polypeptide binding]; other site 881621005533 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 881621005534 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 881621005535 active site 881621005536 FMN binding site [chemical binding]; other site 881621005537 substrate binding site [chemical binding]; other site 881621005538 3Fe-4S cluster binding site [ion binding]; other site 881621005539 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 881621005540 domain interface; other site 881621005541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621005542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621005543 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621005544 putative dimerization interface [polypeptide binding]; other site 881621005545 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621005546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621005547 Coenzyme A binding pocket [chemical binding]; other site 881621005548 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 881621005549 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 881621005550 putative active site [active] 881621005551 metal binding site [ion binding]; metal-binding site 881621005552 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621005553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621005554 substrate binding pocket [chemical binding]; other site 881621005555 membrane-bound complex binding site; other site 881621005556 hinge residues; other site 881621005557 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621005559 Walker A/P-loop; other site 881621005560 ATP binding site [chemical binding]; other site 881621005561 Q-loop/lid; other site 881621005562 ABC transporter signature motif; other site 881621005563 Walker B; other site 881621005564 D-loop; other site 881621005565 H-loop/switch region; other site 881621005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621005567 dimer interface [polypeptide binding]; other site 881621005568 conserved gate region; other site 881621005569 putative PBP binding loops; other site 881621005570 ABC-ATPase subunit interface; other site 881621005571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 881621005572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 881621005573 dimer interface [polypeptide binding]; other site 881621005574 phosphorylation site [posttranslational modification] 881621005575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621005576 ATP binding site [chemical binding]; other site 881621005577 Mg2+ binding site [ion binding]; other site 881621005578 G-X-G motif; other site 881621005579 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 881621005580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621005581 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 881621005582 active site 881621005583 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 881621005584 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 881621005585 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 881621005586 putative NAD(P) binding site [chemical binding]; other site 881621005587 active site 881621005588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621005589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621005590 active site 881621005591 phosphorylation site [posttranslational modification] 881621005592 intermolecular recognition site; other site 881621005593 dimerization interface [polypeptide binding]; other site 881621005594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621005595 DNA binding site [nucleotide binding] 881621005596 FtsX-like permease family; Region: FtsX; pfam02687 881621005597 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621005598 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621005600 Walker A/P-loop; other site 881621005601 ATP binding site [chemical binding]; other site 881621005602 Q-loop/lid; other site 881621005603 ABC transporter signature motif; other site 881621005604 Walker B; other site 881621005605 D-loop; other site 881621005606 H-loop/switch region; other site 881621005607 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621005608 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 881621005609 active site 881621005610 catalytic triad [active] 881621005611 dimer interface [polypeptide binding]; other site 881621005612 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 881621005613 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 881621005614 ADP binding site [chemical binding]; other site 881621005615 magnesium binding site [ion binding]; other site 881621005616 putative shikimate binding site; other site 881621005617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 881621005618 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 881621005619 TRAM domain; Region: TRAM; pfam01938 881621005620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005621 S-adenosylmethionine binding site [chemical binding]; other site 881621005622 putative lipid kinase; Reviewed; Region: PRK13337 881621005623 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 881621005624 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 881621005625 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 881621005626 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 881621005627 GatB domain; Region: GatB_Yqey; pfam02637 881621005628 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 881621005629 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 881621005630 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 881621005631 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 881621005632 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 881621005633 putative dimer interface [polypeptide binding]; other site 881621005634 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 881621005635 putative dimer interface [polypeptide binding]; other site 881621005636 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 881621005637 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 881621005638 nucleotide binding pocket [chemical binding]; other site 881621005639 K-X-D-G motif; other site 881621005640 catalytic site [active] 881621005641 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 881621005642 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 881621005643 Dimer interface [polypeptide binding]; other site 881621005644 BRCT sequence motif; other site 881621005645 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 881621005646 Part of AAA domain; Region: AAA_19; pfam13245 881621005647 Family description; Region: UvrD_C_2; pfam13538 881621005648 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 881621005649 PcrB family; Region: PcrB; pfam01884 881621005650 substrate binding site [chemical binding]; other site 881621005651 putative active site [active] 881621005652 dimer interface [polypeptide binding]; other site 881621005653 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 881621005654 Na2 binding site [ion binding]; other site 881621005655 putative substrate binding site 1 [chemical binding]; other site 881621005656 Na binding site 1 [ion binding]; other site 881621005657 putative substrate binding site 2 [chemical binding]; other site 881621005658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 881621005659 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 881621005660 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 881621005661 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 881621005662 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 881621005663 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 881621005664 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 881621005665 purine monophosphate binding site [chemical binding]; other site 881621005666 dimer interface [polypeptide binding]; other site 881621005667 putative catalytic residues [active] 881621005668 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 881621005669 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 881621005670 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 881621005671 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 881621005672 active site 881621005673 substrate binding site [chemical binding]; other site 881621005674 cosubstrate binding site; other site 881621005675 catalytic site [active] 881621005676 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 881621005677 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 881621005678 dimerization interface [polypeptide binding]; other site 881621005679 putative ATP binding site [chemical binding]; other site 881621005680 amidophosphoribosyltransferase; Provisional; Region: PRK06781 881621005681 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 881621005682 active site 881621005683 tetramer interface [polypeptide binding]; other site 881621005684 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005685 active site 881621005686 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 881621005687 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 881621005688 dimerization interface [polypeptide binding]; other site 881621005689 ATP binding site [chemical binding]; other site 881621005690 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 881621005691 dimerization interface [polypeptide binding]; other site 881621005692 ATP binding site [chemical binding]; other site 881621005693 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 881621005694 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 881621005695 putative active site [active] 881621005696 catalytic triad [active] 881621005697 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 881621005698 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 881621005699 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 881621005700 ATP binding site [chemical binding]; other site 881621005701 active site 881621005702 substrate binding site [chemical binding]; other site 881621005703 adenylosuccinate lyase; Provisional; Region: PRK07492 881621005704 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 881621005705 tetramer interface [polypeptide binding]; other site 881621005706 active site 881621005707 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 881621005708 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 881621005709 NAD binding site [chemical binding]; other site 881621005710 ATP-grasp domain; Region: ATP-grasp; pfam02222 881621005711 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 881621005712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 881621005713 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621005714 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 881621005715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 881621005716 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621005718 Walker A/P-loop; other site 881621005719 ATP binding site [chemical binding]; other site 881621005720 Q-loop/lid; other site 881621005721 ABC transporter signature motif; other site 881621005722 Walker B; other site 881621005723 D-loop; other site 881621005724 H-loop/switch region; other site 881621005725 peptidase T; Region: peptidase-T; TIGR01882 881621005726 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 881621005727 metal binding site [ion binding]; metal-binding site 881621005728 dimer interface [polypeptide binding]; other site 881621005729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 881621005730 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 881621005731 active site 881621005732 putative catalytic site [active] 881621005733 DNA binding site [nucleotide binding] 881621005734 putative phosphate binding site [ion binding]; other site 881621005735 metal binding site A [ion binding]; metal-binding site 881621005736 AP binding site [nucleotide binding]; other site 881621005737 metal binding site B [ion binding]; metal-binding site 881621005738 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 881621005739 23S rRNA binding site [nucleotide binding]; other site 881621005740 L21 binding site [polypeptide binding]; other site 881621005741 L13 binding site [polypeptide binding]; other site 881621005742 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 881621005743 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 881621005744 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 881621005745 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 881621005746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 881621005747 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 881621005748 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 881621005749 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 881621005750 RimM N-terminal domain; Region: RimM; pfam01782 881621005751 PRC-barrel domain; Region: PRC; pfam05239 881621005752 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 881621005753 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 881621005754 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 881621005755 catalytic triad [active] 881621005756 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 881621005757 KH domain; Region: KH_4; pfam13083 881621005758 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 881621005759 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 881621005760 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 881621005761 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 881621005762 signal recognition particle protein; Provisional; Region: PRK10867 881621005763 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 881621005764 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005765 P loop; other site 881621005766 GTP binding site [chemical binding]; other site 881621005767 Signal peptide binding domain; Region: SRP_SPB; pfam02978 881621005768 putative DNA-binding protein; Validated; Region: PRK00118 881621005769 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 881621005770 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 881621005771 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 881621005772 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005773 P loop; other site 881621005774 GTP binding site [chemical binding]; other site 881621005775 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 881621005776 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 881621005777 Walker A/P-loop; other site 881621005778 ATP binding site [chemical binding]; other site 881621005779 Q-loop/lid; other site 881621005780 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 881621005781 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 881621005782 linker region; other site 881621005783 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 881621005784 ABC transporter signature motif; other site 881621005785 Walker B; other site 881621005786 D-loop; other site 881621005787 H-loop/switch region; other site 881621005788 ribonuclease III; Reviewed; Region: rnc; PRK00102 881621005789 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 881621005790 dimerization interface [polypeptide binding]; other site 881621005791 active site 881621005792 metal binding site [ion binding]; metal-binding site 881621005793 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 881621005794 dsRNA binding site [nucleotide binding]; other site 881621005795 acyl carrier protein; Provisional; Region: acpP; PRK00982 881621005796 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 881621005797 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 881621005798 NAD(P) binding site [chemical binding]; other site 881621005799 homotetramer interface [polypeptide binding]; other site 881621005800 homodimer interface [polypeptide binding]; other site 881621005801 active site 881621005802 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 881621005803 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 881621005804 putative phosphate acyltransferase; Provisional; Region: PRK05331 881621005805 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 881621005806 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 881621005807 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 881621005808 Y-family of DNA polymerases; Region: PolY; cl12025 881621005809 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 881621005810 generic binding surface II; other site 881621005811 ssDNA binding site; other site 881621005812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005813 ATP binding site [chemical binding]; other site 881621005814 putative Mg++ binding site [ion binding]; other site 881621005815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005816 nucleotide binding region [chemical binding]; other site 881621005817 ATP-binding site [chemical binding]; other site 881621005818 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 881621005819 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 881621005820 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 881621005821 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 881621005822 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 881621005823 putative L-serine binding site [chemical binding]; other site 881621005824 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 881621005825 DAK2 domain; Region: Dak2; pfam02734 881621005826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 881621005827 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 881621005828 Thiamine pyrophosphokinase; Region: TPK; cd07995 881621005829 active site 881621005830 dimerization interface [polypeptide binding]; other site 881621005831 thiamine binding site [chemical binding]; other site 881621005832 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621005833 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621005834 substrate binding site [chemical binding]; other site 881621005835 hexamer interface [polypeptide binding]; other site 881621005836 metal binding site [ion binding]; metal-binding site 881621005837 GTPase RsgA; Reviewed; Region: PRK00098 881621005838 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 881621005839 RNA binding site [nucleotide binding]; other site 881621005840 homodimer interface [polypeptide binding]; other site 881621005841 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 881621005842 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621005843 GTP/Mg2+ binding site [chemical binding]; other site 881621005844 G4 box; other site 881621005845 G1 box; other site 881621005846 Switch I region; other site 881621005847 G2 box; other site 881621005848 G3 box; other site 881621005849 Switch II region; other site 881621005850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621005851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 881621005852 active site 881621005853 ATP binding site [chemical binding]; other site 881621005854 substrate binding site [chemical binding]; other site 881621005855 activation loop (A-loop); other site 881621005856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 881621005857 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005858 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005859 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 881621005860 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 881621005861 Protein phosphatase 2C; Region: PP2C; pfam00481 881621005862 active site 881621005863 16S rRNA methyltransferase B; Provisional; Region: PRK14902 881621005864 NusB family; Region: NusB; pfam01029 881621005865 putative RNA binding site [nucleotide binding]; other site 881621005866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621005867 S-adenosylmethionine binding site [chemical binding]; other site 881621005868 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 881621005869 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 881621005870 putative active site [active] 881621005871 substrate binding site [chemical binding]; other site 881621005872 putative cosubstrate binding site; other site 881621005873 catalytic site [active] 881621005874 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 881621005875 substrate binding site [chemical binding]; other site 881621005876 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 881621005877 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005878 ATP binding site [chemical binding]; other site 881621005879 putative Mg++ binding site [ion binding]; other site 881621005880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005881 ATP-binding site [chemical binding]; other site 881621005882 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 881621005883 Flavoprotein; Region: Flavoprotein; pfam02441 881621005884 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 881621005885 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 881621005886 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 881621005887 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 881621005888 catalytic site [active] 881621005889 G-X2-G-X-G-K; other site 881621005890 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 881621005891 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 881621005892 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 881621005893 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 881621005894 Domain of unknown function (DUF814); Region: DUF814; pfam05670 881621005895 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 881621005896 NADH(P)-binding; Region: NAD_binding_10; pfam13460 881621005897 putative NAD(P) binding site [chemical binding]; other site 881621005898 homodimer interface [polypeptide binding]; other site 881621005899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005900 active site 881621005901 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 881621005902 active site 881621005903 dimer interface [polypeptide binding]; other site 881621005904 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 881621005905 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 881621005906 heterodimer interface [polypeptide binding]; other site 881621005907 active site 881621005908 FMN binding site [chemical binding]; other site 881621005909 homodimer interface [polypeptide binding]; other site 881621005910 substrate binding site [chemical binding]; other site 881621005911 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 881621005912 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 881621005913 FAD binding pocket [chemical binding]; other site 881621005914 FAD binding motif [chemical binding]; other site 881621005915 phosphate binding motif [ion binding]; other site 881621005916 beta-alpha-beta structure motif; other site 881621005917 NAD binding pocket [chemical binding]; other site 881621005918 Iron coordination center [ion binding]; other site 881621005919 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 881621005920 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005921 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 881621005922 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 881621005923 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005924 ATP-grasp domain; Region: ATP-grasp_4; cl17255 881621005925 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 881621005926 IMP binding site; other site 881621005927 dimer interface [polypeptide binding]; other site 881621005928 interdomain contacts; other site 881621005929 partial ornithine binding site; other site 881621005930 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 881621005931 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 881621005932 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 881621005933 catalytic site [active] 881621005934 subunit interface [polypeptide binding]; other site 881621005935 dihydroorotase; Validated; Region: pyrC; PRK09357 881621005936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621005937 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 881621005938 active site 881621005939 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 881621005940 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621005941 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 881621005942 uracil transporter; Provisional; Region: PRK10720 881621005943 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 881621005944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621005945 active site 881621005946 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621005947 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621005948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621005949 RNA binding surface [nucleotide binding]; other site 881621005950 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 881621005951 active site 881621005952 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 881621005953 lipoprotein signal peptidase; Provisional; Region: PRK14787 881621005954 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621005955 Sulfate transporter family; Region: Sulfate_transp; pfam00916 881621005956 multidrug efflux protein; Reviewed; Region: PRK01766 881621005957 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 881621005958 cation binding site [ion binding]; other site 881621005959 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 881621005960 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 881621005961 metal binding site [ion binding]; metal-binding site 881621005962 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 881621005963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621005964 ABC-ATPase subunit interface; other site 881621005965 dimer interface [polypeptide binding]; other site 881621005966 putative PBP binding regions; other site 881621005967 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 881621005968 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 881621005969 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621005970 MarR family; Region: MarR; pfam01047 881621005971 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 881621005972 C-terminal peptidase (prc); Region: prc; TIGR00225 881621005973 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 881621005974 protein binding site [polypeptide binding]; other site 881621005975 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 881621005976 Catalytic dyad [active] 881621005977 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 881621005978 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005979 metal-binding site [ion binding] 881621005980 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 881621005981 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005982 metal-binding site [ion binding] 881621005983 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621005984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621005985 motif II; other site 881621005986 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621005987 putative homodimer interface [polypeptide binding]; other site 881621005988 putative homotetramer interface [polypeptide binding]; other site 881621005989 putative allosteric switch controlling residues; other site 881621005990 putative metal binding site [ion binding]; other site 881621005991 putative homodimer-homodimer interface [polypeptide binding]; other site 881621005992 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 881621005993 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 881621005994 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 881621005995 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 881621005996 hypothetical protein; Provisional; Region: PRK13672 881621005997 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005998 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621005999 methionine sulfoxide reductase B; Provisional; Region: PRK00222 881621006000 SelR domain; Region: SelR; pfam01641 881621006001 methionine sulfoxide reductase A; Provisional; Region: PRK14054 881621006002 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 881621006003 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 881621006004 active site 881621006005 catalytic triad [active] 881621006006 oxyanion hole [active] 881621006007 EDD domain protein, DegV family; Region: DegV; TIGR00762 881621006008 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 881621006009 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 881621006010 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 881621006011 HTH domain; Region: HTH_11; pfam08279 881621006012 FOG: CBS domain [General function prediction only]; Region: COG0517 881621006013 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 881621006014 PEP synthetase regulatory protein; Provisional; Region: PRK05339 881621006015 pyruvate phosphate dikinase; Provisional; Region: PRK09279 881621006016 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621006017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 881621006018 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 881621006019 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 881621006020 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621006021 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621006022 Predicted membrane protein [Function unknown]; Region: COG4129 881621006023 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 881621006024 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 881621006025 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 881621006026 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 881621006027 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 881621006028 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 881621006029 Clostridial hydrophobic W; Region: ChW; pfam07538 881621006030 Clostridial hydrophobic W; Region: ChW; pfam07538 881621006031 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 881621006032 active site 881621006033 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621006034 substrate binding site [chemical binding]; other site 881621006035 metal binding site [ion binding]; metal-binding site 881621006036 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 881621006037 Methyltransferase domain; Region: Methyltransf_11; pfam08241 881621006038 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 881621006039 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 881621006040 folate binding site [chemical binding]; other site 881621006041 NADP+ binding site [chemical binding]; other site 881621006042 thymidylate synthase; Region: thym_sym; TIGR03284 881621006043 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 881621006044 dimerization interface [polypeptide binding]; other site 881621006045 active site 881621006046 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621006047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621006048 Walker A/P-loop; other site 881621006049 ATP binding site [chemical binding]; other site 881621006050 Q-loop/lid; other site 881621006051 ABC transporter signature motif; other site 881621006052 Walker B; other site 881621006053 D-loop; other site 881621006054 H-loop/switch region; other site 881621006055 ABC transporter; Region: ABC_tran_2; pfam12848 881621006056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621006057 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 881621006058 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 881621006059 Potassium binding sites [ion binding]; other site 881621006060 Cesium cation binding sites [ion binding]; other site 881621006061 manganese transport transcriptional regulator; Provisional; Region: PRK03902 881621006062 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 881621006063 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 881621006064 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 881621006065 DNA-binding site [nucleotide binding]; DNA binding site 881621006066 RNA-binding motif; other site 881621006067 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 881621006068 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621006069 active site 881621006070 5'-3' exonuclease; Region: 53EXOc; smart00475 881621006071 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621006072 active site 881621006073 metal binding site 1 [ion binding]; metal-binding site 881621006074 putative 5' ssDNA interaction site; other site 881621006075 metal binding site 3; metal-binding site 881621006076 metal binding site 2 [ion binding]; metal-binding site 881621006077 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621006078 putative DNA binding site [nucleotide binding]; other site 881621006079 putative metal binding site [ion binding]; other site 881621006080 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 881621006081 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 881621006082 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 881621006083 putative active site [active] 881621006084 xanthine permease; Region: pbuX; TIGR03173 881621006085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621006086 active site 881621006087 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 881621006088 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 881621006089 active site 881621006090 Zn binding site [ion binding]; other site 881621006091 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 881621006092 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 881621006093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 881621006094 cell division protein GpsB; Provisional; Region: PRK14127 881621006095 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621006096 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 881621006097 hypothetical protein; Provisional; Region: PRK13660 881621006098 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 881621006099 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 881621006100 Transglycosylase; Region: Transgly; pfam00912 881621006101 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621006102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 881621006103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621006104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621006105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006106 dimerization interface [polypeptide binding]; other site 881621006107 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621006108 dimer interface [polypeptide binding]; other site 881621006109 FMN binding site [chemical binding]; other site 881621006110 NADPH bind site [chemical binding]; other site 881621006111 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 881621006112 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621006113 minor groove reading motif; other site 881621006114 helix-hairpin-helix signature motif; other site 881621006115 substrate binding pocket [chemical binding]; other site 881621006116 active site 881621006117 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 881621006118 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 881621006119 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 881621006120 similar to unknown protein, C-terminal part 881621006121 similar to unknown protein, N-terminal part 881621006122 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 881621006123 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 881621006124 putative dimer interface [polypeptide binding]; other site 881621006125 putative anticodon binding site; other site 881621006126 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 881621006127 homodimer interface [polypeptide binding]; other site 881621006128 motif 1; other site 881621006129 motif 2; other site 881621006130 active site 881621006131 motif 3; other site 881621006132 aspartate aminotransferase; Provisional; Region: PRK05764 881621006133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006135 homodimer interface [polypeptide binding]; other site 881621006136 catalytic residue [active] 881621006137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 881621006138 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621006139 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 881621006140 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621006141 active site 881621006142 catalytic site [active] 881621006143 substrate binding site [chemical binding]; other site 881621006144 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 881621006145 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 881621006146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621006147 putative Mg++ binding site [ion binding]; other site 881621006148 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 881621006149 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 881621006150 tetramerization interface [polypeptide binding]; other site 881621006151 active site 881621006152 pantoate--beta-alanine ligase; Region: panC; TIGR00018 881621006153 Pantoate-beta-alanine ligase; Region: PanC; cd00560 881621006154 active site 881621006155 ATP-binding site [chemical binding]; other site 881621006156 pantoate-binding site; other site 881621006157 HXXH motif; other site 881621006158 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 881621006159 active site 881621006160 oligomerization interface [polypeptide binding]; other site 881621006161 metal binding site [ion binding]; metal-binding site 881621006162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621006163 catalytic residues [active] 881621006164 Biotin operon repressor [Transcription]; Region: BirA; COG1654 881621006165 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 881621006166 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 881621006167 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 881621006168 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 881621006169 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 881621006170 active site 881621006171 NTP binding site [chemical binding]; other site 881621006172 metal binding triad [ion binding]; metal-binding site 881621006173 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 881621006174 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 881621006175 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 881621006176 active site 881621006177 dimer interfaces [polypeptide binding]; other site 881621006178 catalytic residues [active] 881621006179 dihydrodipicolinate reductase; Provisional; Region: PRK00048 881621006180 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 881621006181 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 881621006182 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 881621006183 homodimer interface [polypeptide binding]; other site 881621006184 metal binding site [ion binding]; metal-binding site 881621006185 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621006186 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621006187 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621006188 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621006189 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 881621006190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 881621006191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621006192 metal binding site [ion binding]; metal-binding site 881621006193 active site 881621006194 I-site; other site 881621006195 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 881621006196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 881621006197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621006198 metal binding site [ion binding]; metal-binding site 881621006199 active site 881621006200 I-site; other site 881621006201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621006202 malate dehydrogenase; Provisional; Region: PRK13529 881621006203 Malic enzyme, N-terminal domain; Region: malic; pfam00390 881621006204 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 881621006205 NAD(P) binding site [chemical binding]; other site 881621006206 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 881621006207 Beta-lactamase; Region: Beta-lactamase; pfam00144 881621006208 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621006209 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621006210 coenzyme A binding site [chemical binding]; other site 881621006211 active site 881621006212 catalytic residues [active] 881621006213 glycine loop; other site 881621006214 HI0933-like protein; Region: HI0933_like; pfam03486 881621006215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621006216 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 881621006217 Predicted membrane protein [Function unknown]; Region: COG4347 881621006218 hypothetical protein; Provisional; Region: PRK03636 881621006219 UPF0302 domain; Region: UPF0302; pfam08864 881621006220 IDEAL domain; Region: IDEAL; pfam08858 881621006221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 881621006222 binding surface 881621006223 TPR motif; other site 881621006224 TPR repeat; Region: TPR_11; pfam13414 881621006225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621006226 binding surface 881621006227 TPR motif; other site 881621006228 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 881621006229 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 881621006230 hinge; other site 881621006231 active site 881621006232 prephenate dehydrogenase; Validated; Region: PRK06545 881621006233 prephenate dehydrogenase; Validated; Region: PRK08507 881621006234 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 881621006235 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 881621006236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006238 homodimer interface [polypeptide binding]; other site 881621006239 catalytic residue [active] 881621006240 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 881621006241 homotrimer interaction site [polypeptide binding]; other site 881621006242 active site 881621006243 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 881621006244 active site 881621006245 dimer interface [polypeptide binding]; other site 881621006246 metal binding site [ion binding]; metal-binding site 881621006247 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 881621006248 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 881621006249 Tetramer interface [polypeptide binding]; other site 881621006250 active site 881621006251 FMN-binding site [chemical binding]; other site 881621006252 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 881621006253 active site 881621006254 multimer interface [polypeptide binding]; other site 881621006255 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621006256 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621006257 substrate binding pocket [chemical binding]; other site 881621006258 chain length determination region; other site 881621006259 substrate-Mg2+ binding site; other site 881621006260 catalytic residues [active] 881621006261 aspartate-rich region 1; other site 881621006262 active site lid residues [active] 881621006263 aspartate-rich region 2; other site 881621006264 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 881621006265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621006266 S-adenosylmethionine binding site [chemical binding]; other site 881621006267 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 881621006268 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 881621006269 homodecamer interface [polypeptide binding]; other site 881621006270 GTP cyclohydrolase I; Provisional; Region: PLN03044 881621006271 active site 881621006272 putative catalytic site residues [active] 881621006273 zinc binding site [ion binding]; other site 881621006274 GTP-CH-I/GFRP interaction surface; other site 881621006275 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 881621006276 IHF dimer interface [polypeptide binding]; other site 881621006277 IHF - DNA interface [nucleotide binding]; other site 881621006278 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 881621006279 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 881621006280 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 881621006281 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 881621006282 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 881621006283 GTP-binding protein Der; Reviewed; Region: PRK00093 881621006284 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 881621006285 G1 box; other site 881621006286 GTP/Mg2+ binding site [chemical binding]; other site 881621006287 Switch I region; other site 881621006288 G2 box; other site 881621006289 Switch II region; other site 881621006290 G3 box; other site 881621006291 G4 box; other site 881621006292 G5 box; other site 881621006293 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 881621006294 G1 box; other site 881621006295 GTP/Mg2+ binding site [chemical binding]; other site 881621006296 Switch I region; other site 881621006297 G2 box; other site 881621006298 G3 box; other site 881621006299 Switch II region; other site 881621006300 G4 box; other site 881621006301 G5 box; other site 881621006302 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 881621006303 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 881621006304 RNA binding site [nucleotide binding]; other site 881621006305 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 881621006306 RNA binding site [nucleotide binding]; other site 881621006307 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 881621006308 RNA binding site [nucleotide binding]; other site 881621006309 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 881621006310 RNA binding site [nucleotide binding]; other site 881621006311 cytidylate kinase; Provisional; Region: cmk; PRK00023 881621006312 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 881621006313 CMP-binding site; other site 881621006314 The sites determining sugar specificity; other site 881621006315 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 881621006316 active site 881621006317 homotetramer interface [polypeptide binding]; other site 881621006318 homodimer interface [polypeptide binding]; other site 881621006319 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621006320 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 881621006321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621006322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621006323 ATP binding site [chemical binding]; other site 881621006324 putative Mg++ binding site [ion binding]; other site 881621006325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621006326 nucleotide binding region [chemical binding]; other site 881621006327 ATP-binding site [chemical binding]; other site 881621006328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 881621006329 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 881621006330 Predicted membrane protein [Function unknown]; Region: COG3601 881621006331 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 881621006332 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 881621006333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621006334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621006335 dimerization interface [polypeptide binding]; other site 881621006336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621006337 dimer interface [polypeptide binding]; other site 881621006338 phosphorylation site [posttranslational modification] 881621006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621006340 ATP binding site [chemical binding]; other site 881621006341 Mg2+ binding site [ion binding]; other site 881621006342 G-X-G motif; other site 881621006343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621006345 active site 881621006346 phosphorylation site [posttranslational modification] 881621006347 intermolecular recognition site; other site 881621006348 dimerization interface [polypeptide binding]; other site 881621006349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621006350 DNA binding site [nucleotide binding] 881621006351 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621006352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006353 RNA binding surface [nucleotide binding]; other site 881621006354 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 881621006355 active site 881621006356 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 881621006357 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 881621006358 diaminopimelate decarboxylase; Region: lysA; TIGR01048 881621006359 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 881621006360 active site 881621006361 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621006362 substrate binding site [chemical binding]; other site 881621006363 catalytic residues [active] 881621006364 dimer interface [polypeptide binding]; other site 881621006365 purine nucleoside phosphorylase; Provisional; Region: PRK08202 881621006366 phosphopentomutase; Provisional; Region: PRK05362 881621006367 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 881621006368 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 881621006369 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 881621006370 active site 881621006371 Int/Topo IB signature motif; other site 881621006372 ferric uptake regulator; Provisional; Region: fur; PRK09462 881621006373 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621006374 metal binding site 2 [ion binding]; metal-binding site 881621006375 putative DNA binding helix; other site 881621006376 metal binding site 1 [ion binding]; metal-binding site 881621006377 dimer interface [polypeptide binding]; other site 881621006378 structural Zn2+ binding site [ion binding]; other site 881621006379 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 881621006380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006381 ABC-ATPase subunit interface; other site 881621006382 dimer interface [polypeptide binding]; other site 881621006383 putative PBP binding regions; other site 881621006384 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 881621006385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006386 ABC-ATPase subunit interface; other site 881621006387 dimer interface [polypeptide binding]; other site 881621006388 putative PBP binding regions; other site 881621006389 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621006390 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 881621006391 putative ligand binding residues [chemical binding]; other site 881621006392 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621006393 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621006394 Walker A/P-loop; other site 881621006395 ATP binding site [chemical binding]; other site 881621006396 Q-loop/lid; other site 881621006397 ABC transporter signature motif; other site 881621006398 Walker B; other site 881621006399 D-loop; other site 881621006400 H-loop/switch region; other site 881621006401 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621006402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621006403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621006404 Transposase; Region: HTH_Tnp_1; cl17663 881621006405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 881621006406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621006407 non-specific DNA binding site [nucleotide binding]; other site 881621006408 salt bridge; other site 881621006409 sequence-specific DNA binding site [nucleotide binding]; other site 881621006410 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621006411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621006412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621006413 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 881621006414 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 881621006415 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621006416 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621006417 Walker A/P-loop; other site 881621006418 ATP binding site [chemical binding]; other site 881621006419 Q-loop/lid; other site 881621006420 ABC transporter signature motif; other site 881621006421 Walker B; other site 881621006422 D-loop; other site 881621006423 H-loop/switch region; other site 881621006424 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 881621006425 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 881621006426 dimer interface [polypeptide binding]; other site 881621006427 ADP-ribose binding site [chemical binding]; other site 881621006428 active site 881621006429 nudix motif; other site 881621006430 metal binding site [ion binding]; metal-binding site 881621006431 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 881621006432 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 881621006433 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 881621006434 active site 881621006435 DNA polymerase IV; Validated; Region: PRK02406 881621006436 DNA binding site [nucleotide binding] 881621006437 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 881621006438 similar to transport protein, C-terminal part 881621006439 similar to transport protein, N-terminal part 881621006440 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621006441 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621006442 metal binding site [ion binding]; metal-binding site 881621006443 dimer interface [polypeptide binding]; other site 881621006444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621006445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 881621006446 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621006447 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621006448 metal binding site [ion binding]; metal-binding site 881621006449 dimer interface [polypeptide binding]; other site 881621006450 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 881621006451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006452 NAD(P) binding site [chemical binding]; other site 881621006453 active site 881621006454 ribonuclease Z; Region: RNase_Z; TIGR02651 881621006455 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 881621006456 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 881621006457 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 881621006458 Uncharacterized conserved protein [Function unknown]; Region: COG5506 881621006459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621006460 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 881621006461 Coenzyme A binding pocket [chemical binding]; other site 881621006462 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 881621006463 6-phosphogluconate dehydratase; Region: edd; TIGR01196 881621006464 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 881621006465 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006466 PYR/PP interface [polypeptide binding]; other site 881621006467 dimer interface [polypeptide binding]; other site 881621006468 TPP binding site [chemical binding]; other site 881621006469 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621006470 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 881621006471 TPP-binding site [chemical binding]; other site 881621006472 dimer interface [polypeptide binding]; other site 881621006473 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 881621006474 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 881621006475 putative valine binding site [chemical binding]; other site 881621006476 dimer interface [polypeptide binding]; other site 881621006477 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 881621006478 ketol-acid reductoisomerase; Provisional; Region: PRK05479 881621006479 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 881621006480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 881621006481 2-isopropylmalate synthase; Validated; Region: PRK00915 881621006482 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 881621006483 active site 881621006484 catalytic residues [active] 881621006485 metal binding site [ion binding]; metal-binding site 881621006486 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 881621006487 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 881621006488 tartrate dehydrogenase; Region: TTC; TIGR02089 881621006489 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 881621006490 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 881621006491 substrate binding site [chemical binding]; other site 881621006492 ligand binding site [chemical binding]; other site 881621006493 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 881621006494 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 881621006495 substrate binding site [chemical binding]; other site 881621006496 threonine dehydratase; Validated; Region: PRK08639 881621006497 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 881621006498 tetramer interface [polypeptide binding]; other site 881621006499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006500 catalytic residue [active] 881621006501 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621006502 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 881621006503 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 881621006504 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621006505 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621006506 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 881621006507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006509 DNA binding site [nucleotide binding] 881621006510 domain linker motif; other site 881621006511 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006512 dimerization interface [polypeptide binding]; other site 881621006513 ligand binding site [chemical binding]; other site 881621006514 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 881621006515 intersubunit interface [polypeptide binding]; other site 881621006516 active site 881621006517 catalytic residue [active] 881621006518 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621006519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 881621006520 DNA binding residues [nucleotide binding] 881621006521 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621006522 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 881621006523 active pocket/dimerization site; other site 881621006524 active site 881621006525 phosphorylation site [posttranslational modification] 881621006526 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006527 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 881621006528 putative active site [active] 881621006529 SIS domain; Region: SIS; pfam01380 881621006530 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006531 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621006532 dimer interface [polypeptide binding]; other site 881621006533 active site 881621006534 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621006535 dimer interface [polypeptide binding]; other site 881621006536 active site 881621006537 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 881621006538 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 881621006539 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 881621006540 active site 881621006541 phosphorylation site [posttranslational modification] 881621006542 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006544 DNA-binding site [nucleotide binding]; DNA binding site 881621006545 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 881621006546 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006548 DNA-binding site [nucleotide binding]; DNA binding site 881621006549 UTRA domain; Region: UTRA; pfam07702 881621006550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621006551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621006552 active site 881621006553 catalytic tetrad [active] 881621006554 acetolactate synthase; Reviewed; Region: PRK08617 881621006555 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006556 PYR/PP interface [polypeptide binding]; other site 881621006557 dimer interface [polypeptide binding]; other site 881621006558 TPP binding site [chemical binding]; other site 881621006559 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621006560 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 881621006561 TPP-binding site [chemical binding]; other site 881621006562 dimer interface [polypeptide binding]; other site 881621006563 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621006564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621006565 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 881621006566 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621006567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 881621006568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006569 putative PBP binding loops; other site 881621006570 dimer interface [polypeptide binding]; other site 881621006571 ABC-ATPase subunit interface; other site 881621006572 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621006573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006574 dimer interface [polypeptide binding]; other site 881621006575 conserved gate region; other site 881621006576 ABC-ATPase subunit interface; other site 881621006577 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 881621006578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621006579 active site 881621006580 phosphorylation site [posttranslational modification] 881621006581 intermolecular recognition site; other site 881621006582 dimerization interface [polypeptide binding]; other site 881621006583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006584 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621006585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 881621006586 dimerization interface [polypeptide binding]; other site 881621006587 Histidine kinase; Region: His_kinase; pfam06580 881621006588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621006589 ATP binding site [chemical binding]; other site 881621006590 Mg2+ binding site [ion binding]; other site 881621006591 G-X-G motif; other site 881621006592 Predicted integral membrane protein [Function unknown]; Region: COG5578 881621006593 Uncharacterized conserved protein [Function unknown]; Region: COG3538 881621006594 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 881621006595 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006596 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 881621006597 active site 881621006598 metal binding site [ion binding]; metal-binding site 881621006599 homodimer interface [polypeptide binding]; other site 881621006600 catalytic site [active] 881621006601 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 881621006602 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006603 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 881621006604 active site 881621006605 catalytic site [active] 881621006606 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 881621006607 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 881621006608 DNA-binding site [nucleotide binding]; DNA binding site 881621006609 RNA-binding motif; other site 881621006610 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621006611 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 881621006612 active site 881621006613 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 881621006614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 881621006615 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 881621006616 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 881621006617 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006618 HIGH motif; other site 881621006619 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006620 active site 881621006621 KMSKS motif; other site 881621006622 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 881621006623 tRNA binding surface [nucleotide binding]; other site 881621006624 anticodon binding site; other site 881621006625 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621006626 DivIVA protein; Region: DivIVA; pfam05103 881621006627 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621006628 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 881621006629 HTH domain; Region: HTH_11; pfam08279 881621006630 3H domain; Region: 3H; pfam02829 881621006631 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 881621006632 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 881621006633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621006634 catalytic residue [active] 881621006635 L-aspartate oxidase; Provisional; Region: PRK08071 881621006636 L-aspartate oxidase; Provisional; Region: PRK06175 881621006637 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 881621006638 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 881621006639 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 881621006640 dimerization interface [polypeptide binding]; other site 881621006641 active site 881621006642 quinolinate synthetase; Provisional; Region: PRK09375 881621006643 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 881621006644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006645 RNA binding surface [nucleotide binding]; other site 881621006646 YGGT family; Region: YGGT; pfam02325 881621006647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 881621006648 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 881621006649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621006650 catalytic residue [active] 881621006651 cell division protein FtsZ; Validated; Region: PRK09330 881621006652 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 881621006653 nucleotide binding site [chemical binding]; other site 881621006654 SulA interaction site; other site 881621006655 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 881621006656 Cell division protein FtsA; Region: FtsA; smart00842 881621006657 Cell division protein FtsA; Region: FtsA; pfam14450 881621006658 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 881621006659 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 881621006660 Cell division protein FtsQ; Region: FtsQ; pfam03799 881621006661 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 881621006662 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 881621006663 active site 881621006664 homodimer interface [polypeptide binding]; other site 881621006665 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 881621006666 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006667 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006668 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 881621006669 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 881621006670 Mg++ binding site [ion binding]; other site 881621006671 putative catalytic motif [active] 881621006672 putative substrate binding site [chemical binding]; other site 881621006673 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 881621006674 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621006675 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006676 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006677 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621006678 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621006679 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 881621006680 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 881621006681 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 881621006682 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 881621006683 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 881621006684 MraW methylase family; Region: Methyltransf_5; pfam01795 881621006685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 881621006686 MraZ protein; Region: MraZ; pfam02381 881621006687 MraZ protein; Region: MraZ; pfam02381 881621006688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006690 putative substrate translocation pore; other site 881621006691 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 881621006692 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 881621006693 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 881621006694 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 881621006695 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 881621006696 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 881621006697 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 881621006698 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 881621006699 hypothetical protein; Provisional; Region: PRK13670 881621006700 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 881621006701 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 881621006702 AAA domain; Region: AAA_21; pfam13304 881621006703 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 881621006704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621006705 AAA domain; Region: AAA_21; pfam13304 881621006706 Walker A/P-loop; other site 881621006707 ATP binding site [chemical binding]; other site 881621006708 Q-loop/lid; other site 881621006709 ABC transporter signature motif; other site 881621006710 Walker B; other site 881621006711 D-loop; other site 881621006712 H-loop/switch region; other site 881621006713 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 881621006714 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 881621006715 protein binding site [polypeptide binding]; other site 881621006716 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 881621006717 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 881621006718 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 881621006719 active site 881621006720 (T/H)XGH motif; other site 881621006721 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 881621006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621006723 S-adenosylmethionine binding site [chemical binding]; other site 881621006724 hypothetical protein; Provisional; Region: PRK02886 881621006725 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 881621006726 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 881621006727 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 881621006728 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 881621006729 UbiA prenyltransferase family; Region: UbiA; pfam01040 881621006730 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 881621006731 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 881621006732 Ion transport protein; Region: Ion_trans; pfam00520 881621006733 Ion channel; Region: Ion_trans_2; pfam07885 881621006734 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 881621006735 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 881621006736 SCP-2 sterol transfer family; Region: SCP2; pfam02036 881621006737 similar to Peptide methionine sulfoxide reductase MsrB internal part 881621006738 similar to Peptide methionine sulfoxide reductase MsrB C-terminal part 881621006739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 881621006740 MOSC domain; Region: MOSC; pfam03473 881621006741 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 881621006742 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 881621006743 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 881621006744 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 881621006745 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 881621006746 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 881621006747 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 881621006748 active site 881621006749 similar to soluble internalin, partial 881621006750 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621006751 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621006752 LRR adjacent; Region: LRR_adjacent; pfam08191 881621006753 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621006754 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 881621006755 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 881621006756 ring oligomerisation interface [polypeptide binding]; other site 881621006757 ATP/Mg binding site [chemical binding]; other site 881621006758 stacking interactions; other site 881621006759 hinge regions; other site 881621006760 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 881621006761 oligomerisation interface [polypeptide binding]; other site 881621006762 mobile loop; other site 881621006763 roof hairpin; other site 881621006764 CAAX protease self-immunity; Region: Abi; pfam02517 881621006765 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 881621006766 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 881621006767 CoA binding domain; Region: CoA_binding; pfam02629 881621006768 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621006769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621006770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621006771 ABC transporter; Region: ABC_tran_2; pfam12848 881621006772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 881621006773 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621006774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621006775 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621006776 UGMP family protein; Validated; Region: PRK09604 881621006777 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 881621006778 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 881621006779 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 881621006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006781 Coenzyme A binding pocket [chemical binding]; other site 881621006782 Glycoprotease family; Region: Peptidase_M22; pfam00814 881621006783 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 881621006784 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 881621006785 CrcB-like protein; Region: CRCB; cl09114 881621006786 CrcB-like protein; Region: CRCB; cl09114 881621006787 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 881621006788 Phosphotransferase enzyme family; Region: APH; pfam01636 881621006789 active site 881621006790 substrate binding site [chemical binding]; other site 881621006791 ATP binding site [chemical binding]; other site 881621006792 Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621006793 putative peptidoglycan bound protein (LPXTG motif),N-terminal part 881621006794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621006795 non-specific DNA binding site [nucleotide binding]; other site 881621006796 salt bridge; other site 881621006797 sequence-specific DNA binding site [nucleotide binding]; other site 881621006798 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 881621006799 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 881621006800 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 881621006801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621006802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621006803 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 881621006804 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621006805 substrate binding pocket [chemical binding]; other site 881621006806 argininosuccinate synthase; Provisional; Region: PRK13820 881621006807 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 881621006808 ANP binding site [chemical binding]; other site 881621006809 Substrate Binding Site II [chemical binding]; other site 881621006810 Substrate Binding Site I [chemical binding]; other site 881621006811 argininosuccinate lyase; Provisional; Region: PRK00855 881621006812 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 881621006813 active sites [active] 881621006814 tetramer interface [polypeptide binding]; other site 881621006815 BCCT family transporter; Region: BCCT; pfam02028 881621006816 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 881621006817 active site 881621006818 intersubunit interface [polypeptide binding]; other site 881621006819 Zn2+ binding site [ion binding]; other site 881621006820 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621006821 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621006822 putative substrate binding site [chemical binding]; other site 881621006823 putative ATP binding site [chemical binding]; other site 881621006824 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 881621006825 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621006826 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621006827 active site 881621006828 P-loop; other site 881621006829 phosphorylation site [posttranslational modification] 881621006830 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006831 active site 881621006832 phosphorylation site [posttranslational modification] 881621006833 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621006834 PRD domain; Region: PRD; pfam00874 881621006835 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006836 active site 881621006837 P-loop; other site 881621006838 phosphorylation site [posttranslational modification] 881621006839 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 881621006840 active site 881621006841 phosphorylation site [posttranslational modification] 881621006842 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621006843 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621006844 WxL domain surface cell wall-binding; Region: WxL; pfam13731 881621006845 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 881621006846 similar to internalin, peptidoglycan bound protein (LPxTG motif, partial 881621006847 similar to unknown proteins, N-terminal part 881621006848 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 881621006849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006850 DNA-binding site [nucleotide binding]; DNA binding site 881621006851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006853 homodimer interface [polypeptide binding]; other site 881621006854 catalytic residue [active] 881621006855 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 881621006856 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 881621006857 active site 881621006858 multimer interface [polypeptide binding]; other site 881621006859 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 881621006860 predicted active site [active] 881621006861 catalytic triad [active] 881621006862 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 881621006863 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 881621006864 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 881621006865 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 881621006866 G1 box; other site 881621006867 GTP/Mg2+ binding site [chemical binding]; other site 881621006868 Switch I region; other site 881621006869 G2 box; other site 881621006870 G3 box; other site 881621006871 Switch II region; other site 881621006872 G4 box; other site 881621006873 G5 box; other site 881621006874 Nucleoside recognition; Region: Gate; pfam07670 881621006875 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 881621006876 Nucleoside recognition; Region: Gate; pfam07670 881621006877 Similar to ABC transporter, ATP-binding protein. Truncated, C-terminal part 881621006878 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 881621006879 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 881621006880 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 881621006881 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621006882 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621006883 putative active site [active] 881621006884 putative metal binding site [ion binding]; other site 881621006885 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621006886 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 881621006887 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 881621006888 dimer interface [polypeptide binding]; other site 881621006889 FMN binding site [chemical binding]; other site 881621006890 NADPH bind site [chemical binding]; other site 881621006891 Helix-turn-helix domain; Region: HTH_17; pfam12728 881621006892 putative heme peroxidase; Provisional; Region: PRK12276 881621006893 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621006894 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621006895 Walker A/P-loop; other site 881621006896 ATP binding site [chemical binding]; other site 881621006897 Q-loop/lid; other site 881621006898 ABC transporter signature motif; other site 881621006899 Walker B; other site 881621006900 D-loop; other site 881621006901 H-loop/switch region; other site 881621006902 FtsX-like permease family; Region: FtsX; pfam02687 881621006903 FtsX-like permease family; Region: FtsX; pfam02687 881621006904 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621006905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006906 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621006907 Coenzyme A binding pocket [chemical binding]; other site 881621006908 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 881621006909 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 881621006910 active site 881621006911 substrate binding site [chemical binding]; other site 881621006912 metal binding site [ion binding]; metal-binding site 881621006913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 881621006914 YbbR-like protein; Region: YbbR; pfam07949 881621006915 YbbR-like protein; Region: YbbR; pfam07949 881621006916 YbbR-like protein; Region: YbbR; pfam07949 881621006917 Uncharacterized conserved protein [Function unknown]; Region: COG1624 881621006918 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 881621006919 maltose phosphorylase; Provisional; Region: PRK13807 881621006920 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621006921 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 881621006922 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621006923 Predicted integral membrane protein [Function unknown]; Region: COG5521 881621006924 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621006925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006926 dimer interface [polypeptide binding]; other site 881621006927 conserved gate region; other site 881621006928 putative PBP binding loops; other site 881621006929 ABC-ATPase subunit interface; other site 881621006930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621006931 dimer interface [polypeptide binding]; other site 881621006932 conserved gate region; other site 881621006933 putative PBP binding loops; other site 881621006934 ABC-ATPase subunit interface; other site 881621006935 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621006936 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621006937 maltodextrin glucosidase; Provisional; Region: PRK10785 881621006938 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 881621006939 homodimer interface [polypeptide binding]; other site 881621006940 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 881621006941 active site 881621006942 homodimer interface [polypeptide binding]; other site 881621006943 catalytic site [active] 881621006944 CAAX protease self-immunity; Region: Abi; cl00558 881621006945 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006946 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006947 DNA binding site [nucleotide binding] 881621006948 domain linker motif; other site 881621006949 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006950 ligand binding site [chemical binding]; other site 881621006951 dimerization interface [polypeptide binding]; other site 881621006952 Amino acid permease; Region: AA_permease_2; pfam13520 881621006953 similar to other protein, C-terminal part 881621006954 similar to other protein, N-terminal part 881621006955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621006956 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621006957 ligand binding site [chemical binding]; other site 881621006958 flexible hinge region; other site 881621006959 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621006960 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621006961 intersubunit interface [polypeptide binding]; other site 881621006962 active site 881621006963 zinc binding site [ion binding]; other site 881621006964 Na+ binding site [ion binding]; other site 881621006965 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621006966 intersubunit interface [polypeptide binding]; other site 881621006967 active site 881621006968 zinc binding site [ion binding]; other site 881621006969 Na+ binding site [ion binding]; other site 881621006970 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 881621006971 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621006972 active site 881621006973 P-loop; other site 881621006974 phosphorylation site [posttranslational modification] 881621006975 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006976 active site 881621006977 phosphorylation site [posttranslational modification] 881621006978 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621006979 HTH domain; Region: HTH_11; pfam08279 881621006980 PRD domain; Region: PRD; pfam00874 881621006981 PRD domain; Region: PRD; pfam00874 881621006982 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006983 active site 881621006984 P-loop; other site 881621006985 phosphorylation site [posttranslational modification] 881621006986 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 881621006987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621006988 Walker A/P-loop; other site 881621006989 ATP binding site [chemical binding]; other site 881621006990 Q-loop/lid; other site 881621006991 ABC transporter signature motif; other site 881621006992 Walker B; other site 881621006993 D-loop; other site 881621006994 H-loop/switch region; other site 881621006995 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 881621006996 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621006997 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621006998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006999 Coenzyme A binding pocket [chemical binding]; other site 881621007000 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621007001 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 881621007002 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 881621007003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621007004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621007005 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 881621007006 putative dimerization interface [polypeptide binding]; other site 881621007007 Predicted membrane protein [Function unknown]; Region: COG2855 881621007008 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 881621007009 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 881621007010 putative metal binding site [ion binding]; other site 881621007011 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 881621007012 homodimer interface [polypeptide binding]; other site 881621007013 chemical substrate binding site [chemical binding]; other site 881621007014 oligomer interface [polypeptide binding]; other site 881621007015 metal binding site [ion binding]; metal-binding site 881621007016 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621007017 catalytic residues [active] 881621007018 flavodoxin; Provisional; Region: PRK09271 881621007019 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 881621007020 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 881621007021 dimer interface [polypeptide binding]; other site 881621007022 putative radical transfer pathway; other site 881621007023 diiron center [ion binding]; other site 881621007024 tyrosyl radical; other site 881621007025 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 881621007026 Class I ribonucleotide reductase; Region: RNR_I; cd01679 881621007027 active site 881621007028 dimer interface [polypeptide binding]; other site 881621007029 catalytic residues [active] 881621007030 effector binding site; other site 881621007031 R2 peptide binding site; other site 881621007032 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 881621007033 CsbD-like; Region: CsbD; cl17424 881621007034 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621007035 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621007036 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 881621007037 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621007038 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 881621007039 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621007040 conserved cys residue [active] 881621007041 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621007042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621007043 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 881621007044 Cupin domain; Region: Cupin_2; cl17218 881621007045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621007047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007048 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621007049 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 881621007050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621007051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621007052 ligand binding site [chemical binding]; other site 881621007053 flexible hinge region; other site 881621007054 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 881621007055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 881621007056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621007057 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 881621007058 dimer interface [polypeptide binding]; other site 881621007059 active site 881621007060 metal binding site [ion binding]; metal-binding site 881621007061 glutathione binding site [chemical binding]; other site 881621007062 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 881621007063 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 881621007064 FMN binding site [chemical binding]; other site 881621007065 substrate binding site [chemical binding]; other site 881621007066 putative catalytic residue [active] 881621007067 similar to antiporter proteins, C-terminal part 881621007068 similar to antiporter proteins, N-terminal part 881621007069 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 881621007070 Coenzyme A transferase; Region: CoA_trans; smart00882 881621007071 Coenzyme A transferase; Region: CoA_trans; cl17247 881621007072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621007073 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 881621007074 Walker A motif; other site 881621007075 ATP binding site [chemical binding]; other site 881621007076 Walker B motif; other site 881621007077 arginine finger; other site 881621007078 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 881621007079 similar putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621007080 similar putative peptidoglycan linked protein (LPXTG motif), central part 881621007081 similar putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621007082 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621007083 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007084 Collagen binding domain; Region: Collagen_bind; pfam05737 881621007085 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007086 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007087 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007088 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007089 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007090 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621007091 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621007092 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007093 Collagen binding domain; Region: Collagen_bind; pfam05737 881621007094 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007095 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007096 Cna protein B-type domain; Region: Cna_B; pfam05738 881621007097 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621007098 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 881621007099 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 881621007100 active site 881621007101 catalytic site [active] 881621007102 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621007103 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621007104 Walker A/P-loop; other site 881621007105 ATP binding site [chemical binding]; other site 881621007106 Q-loop/lid; other site 881621007107 ABC transporter signature motif; other site 881621007108 Walker B; other site 881621007109 D-loop; other site 881621007110 H-loop/switch region; other site 881621007111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621007112 ABC-ATPase subunit interface; other site 881621007113 dimer interface [polypeptide binding]; other site 881621007114 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 881621007115 putative PBP binding regions; other site 881621007116 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 881621007117 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621007118 intersubunit interface [polypeptide binding]; other site 881621007119 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621007120 heme-binding site [chemical binding]; other site 881621007121 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 881621007122 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621007123 heme-binding site [chemical binding]; other site 881621007124 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621007125 heme-binding site [chemical binding]; other site 881621007126 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621007127 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621007128 heme-binding site [chemical binding]; other site 881621007129 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621007130 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621007131 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 881621007132 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 881621007133 active site 881621007134 Zn binding site [ion binding]; other site 881621007135 Competence protein CoiA-like family; Region: CoiA; cl11541 881621007136 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 881621007137 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 881621007138 ArsC family; Region: ArsC; pfam03960 881621007139 putative catalytic residues [active] 881621007140 thiol/disulfide switch; other site 881621007141 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 881621007142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 881621007143 Walker A/P-loop; other site 881621007144 ATP binding site [chemical binding]; other site 881621007145 Q-loop/lid; other site 881621007146 ABC transporter signature motif; other site 881621007147 Walker B; other site 881621007148 D-loop; other site 881621007149 H-loop/switch region; other site 881621007150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621007151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 881621007152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 881621007153 Walker A/P-loop; other site 881621007154 ATP binding site [chemical binding]; other site 881621007155 Q-loop/lid; other site 881621007156 ABC transporter signature motif; other site 881621007157 Walker B; other site 881621007158 D-loop; other site 881621007159 H-loop/switch region; other site 881621007160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621007161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007163 dimer interface [polypeptide binding]; other site 881621007164 conserved gate region; other site 881621007165 putative PBP binding loops; other site 881621007166 ABC-ATPase subunit interface; other site 881621007167 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007169 dimer interface [polypeptide binding]; other site 881621007170 conserved gate region; other site 881621007171 putative PBP binding loops; other site 881621007172 ABC-ATPase subunit interface; other site 881621007173 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621007174 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621007175 peptide binding site [polypeptide binding]; other site 881621007176 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 881621007177 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 881621007178 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 881621007179 active site 881621007180 HIGH motif; other site 881621007181 dimer interface [polypeptide binding]; other site 881621007182 KMSKS motif; other site 881621007183 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 881621007184 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621007185 MarR family; Region: MarR; pfam01047 881621007186 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 881621007187 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 881621007188 dimer interface [polypeptide binding]; other site 881621007189 active site 881621007190 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 881621007191 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 881621007192 dimer interface [polypeptide binding]; other site 881621007193 active site 881621007194 CoA binding pocket [chemical binding]; other site 881621007195 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 881621007196 SH3-like domain; Region: SH3_8; pfam13457 881621007197 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 881621007198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621007199 catalytic core [active] 881621007200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621007201 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 881621007202 Clp amino terminal domain; Region: Clp_N; pfam02861 881621007203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621007204 Walker A motif; other site 881621007205 ATP binding site [chemical binding]; other site 881621007206 Walker B motif; other site 881621007207 arginine finger; other site 881621007208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621007209 Walker A motif; other site 881621007210 ATP binding site [chemical binding]; other site 881621007211 Walker B motif; other site 881621007212 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 881621007213 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 881621007214 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 881621007215 similar to unknown protein, C-terminal part 881621007216 similar to unknown protein, N-terminal part 881621007217 Predicted acetyltransferase [General function prediction only]; Region: COG3393 881621007218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 881621007219 ferrochelatase; Provisional; Region: PRK12435 881621007220 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 881621007221 C-terminal domain interface [polypeptide binding]; other site 881621007222 active site 881621007223 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 881621007224 active site 881621007225 N-terminal domain interface [polypeptide binding]; other site 881621007226 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 881621007227 substrate binding site [chemical binding]; other site 881621007228 active site 881621007229 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 881621007230 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 881621007231 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621007232 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621007233 Walker A/P-loop; other site 881621007234 ATP binding site [chemical binding]; other site 881621007235 Q-loop/lid; other site 881621007236 ABC transporter signature motif; other site 881621007237 Walker B; other site 881621007238 D-loop; other site 881621007239 H-loop/switch region; other site 881621007240 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 881621007241 HIT family signature motif; other site 881621007242 catalytic residue [active] 881621007243 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 881621007244 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621007245 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 881621007246 SurA N-terminal domain; Region: SurA_N_3; cl07813 881621007247 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 881621007248 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 881621007249 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 881621007250 generic binding surface II; other site 881621007251 generic binding surface I; other site 881621007252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621007253 Zn2+ binding site [ion binding]; other site 881621007254 Mg2+ binding site [ion binding]; other site 881621007255 Uncharacterized conserved protein [Function unknown]; Region: COG4717 881621007256 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621007257 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621007258 active site 881621007259 metal binding site [ion binding]; metal-binding site 881621007260 DNA binding site [nucleotide binding] 881621007261 hypothetical protein; Provisional; Region: PRK13676 881621007262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 881621007263 fumarate hydratase; Reviewed; Region: fumC; PRK00485 881621007264 Class II fumarases; Region: Fumarase_classII; cd01362 881621007265 active site 881621007266 tetramer interface [polypeptide binding]; other site 881621007267 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 881621007268 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621007269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621007270 Walker A/P-loop; other site 881621007271 ATP binding site [chemical binding]; other site 881621007272 Q-loop/lid; other site 881621007273 ABC transporter signature motif; other site 881621007274 Walker B; other site 881621007275 D-loop; other site 881621007276 H-loop/switch region; other site 881621007277 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621007278 Transglycosylase; Region: Transgly; pfam00912 881621007279 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621007280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 881621007281 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 881621007282 Low molecular weight phosphatase family; Region: LMWPc; cl00105 881621007283 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007284 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 881621007285 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621007286 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621007287 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621007288 Transporter associated domain; Region: CorC_HlyC; smart01091 881621007289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621007290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621007291 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621007292 putative dimerization interface [polypeptide binding]; other site 881621007293 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621007294 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 881621007295 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 881621007296 active site 881621007297 FMN binding site [chemical binding]; other site 881621007298 substrate binding site [chemical binding]; other site 881621007299 putative catalytic residue [active] 881621007300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 881621007301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007302 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621007303 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621007304 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621007305 shikimate binding site; other site 881621007306 NAD(P) binding site [chemical binding]; other site 881621007307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007309 putative substrate translocation pore; other site 881621007310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007312 putative substrate translocation pore; other site 881621007313 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 881621007314 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621007315 DNA binding site [nucleotide binding] 881621007316 active site 881621007317 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621007318 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621007319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621007321 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621007322 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 881621007323 active site 881621007324 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 881621007325 putative dimer interface [polypeptide binding]; other site 881621007326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621007327 ligand binding site [chemical binding]; other site 881621007328 Zn binding site [ion binding]; other site 881621007329 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 881621007330 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 881621007331 active site 881621007332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007334 active site 881621007335 catalytic tetrad [active] 881621007336 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 881621007337 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 881621007338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621007339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 881621007340 substrate binding pocket [chemical binding]; other site 881621007341 membrane-bound complex binding site; other site 881621007342 hinge residues; other site 881621007343 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621007344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007345 dimer interface [polypeptide binding]; other site 881621007346 conserved gate region; other site 881621007347 putative PBP binding loops; other site 881621007348 ABC-ATPase subunit interface; other site 881621007349 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621007350 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 881621007351 Walker A/P-loop; other site 881621007352 ATP binding site [chemical binding]; other site 881621007353 Q-loop/lid; other site 881621007354 ABC transporter signature motif; other site 881621007355 Walker B; other site 881621007356 D-loop; other site 881621007357 H-loop/switch region; other site 881621007358 aspartate aminotransferase; Provisional; Region: PRK06348 881621007359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621007360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007361 homodimer interface [polypeptide binding]; other site 881621007362 catalytic residue [active] 881621007363 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 881621007364 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 881621007365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007366 motif II; other site 881621007367 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 881621007368 intracellular protease, PfpI family; Region: PfpI; TIGR01382 881621007369 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 881621007370 proposed catalytic triad [active] 881621007371 conserved cys residue [active] 881621007372 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621007373 methionine cluster; other site 881621007374 active site 881621007375 phosphorylation site [posttranslational modification] 881621007376 metal binding site [ion binding]; metal-binding site 881621007377 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 881621007378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007379 Coenzyme A binding pocket [chemical binding]; other site 881621007380 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 881621007381 esterase; Provisional; Region: PRK10566 881621007382 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 881621007383 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007385 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621007386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007387 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621007388 hypothetical protein; Provisional; Region: PRK13673 881621007389 similar to unknown protein, C-terminal part 881621007390 Similar to unknown protein, N-terminal part 881621007391 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 881621007392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 881621007393 Family description; Region: UvrD_C_2; pfam13538 881621007394 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 881621007395 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 881621007396 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 881621007397 IDEAL domain; Region: IDEAL; pfam08858 881621007398 ComK protein; Region: ComK; pfam06338 881621007399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 881621007400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621007401 non-specific DNA binding site [nucleotide binding]; other site 881621007402 salt bridge; other site 881621007403 sequence-specific DNA binding site [nucleotide binding]; other site 881621007404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007405 active site 881621007406 phosphorylation site [posttranslational modification] 881621007407 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 881621007408 active site 881621007409 P-loop; other site 881621007410 phosphorylation site [posttranslational modification] 881621007411 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 881621007412 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621007413 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621007414 putative substrate binding site [chemical binding]; other site 881621007415 putative ATP binding site [chemical binding]; other site 881621007416 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621007417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621007418 DNA-binding site [nucleotide binding]; DNA binding site 881621007419 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621007420 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 881621007421 trimer interface [polypeptide binding]; other site 881621007422 active site 881621007423 G bulge; other site 881621007424 Uncharacterized conserved protein [Function unknown]; Region: COG1683 881621007425 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 881621007426 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 881621007427 non-specific DNA interactions [nucleotide binding]; other site 881621007428 DNA binding site [nucleotide binding] 881621007429 sequence specific DNA binding site [nucleotide binding]; other site 881621007430 putative cAMP binding site [chemical binding]; other site 881621007431 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 881621007432 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621007433 substrate binding site [chemical binding]; other site 881621007434 ATP binding site [chemical binding]; other site 881621007435 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621007436 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621007437 RNA binding surface [nucleotide binding]; other site 881621007438 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 881621007439 active site 881621007440 uracil binding [chemical binding]; other site 881621007441 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621007442 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 881621007443 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 881621007444 active site 881621007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007447 putative substrate translocation pore; other site 881621007448 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 881621007449 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 881621007450 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621007451 active site 881621007452 trimer interface [polypeptide binding]; other site 881621007453 allosteric site; other site 881621007454 active site lid [active] 881621007455 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621007456 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007458 active site 881621007459 motif I; other site 881621007460 motif II; other site 881621007461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 881621007462 Predicted membrane protein [Function unknown]; Region: COG1511 881621007463 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621007464 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 881621007465 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 881621007466 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621007467 Transcriptional regulator; Region: Rrf2; pfam02082 881621007468 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 881621007469 L-tyrosine decarboxylase; Provisional; Region: PRK13520 881621007470 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621007471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007472 catalytic residue [active] 881621007473 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 881621007474 Mga helix-turn-helix domain; Region: Mga; pfam05043 881621007475 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 881621007476 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621007477 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 881621007478 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 881621007479 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 881621007480 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 881621007481 active site 881621007482 dimer interface [polypeptide binding]; other site 881621007483 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 881621007484 dimer interface [polypeptide binding]; other site 881621007485 active site 881621007486 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 881621007487 nudix motif; other site 881621007488 general stress protein 13; Validated; Region: PRK08059 881621007489 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 881621007490 RNA binding site [nucleotide binding]; other site 881621007491 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 881621007492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621007493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007494 homodimer interface [polypeptide binding]; other site 881621007495 catalytic residue [active] 881621007496 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621007497 FtsX-like permease family; Region: FtsX; pfam02687 881621007498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621007499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 881621007500 Walker A/P-loop; other site 881621007501 ATP binding site [chemical binding]; other site 881621007502 Q-loop/lid; other site 881621007503 ABC transporter signature motif; other site 881621007504 Walker B; other site 881621007505 D-loop; other site 881621007506 H-loop/switch region; other site 881621007507 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621007508 active site 881621007509 P-loop; other site 881621007510 phosphorylation site [posttranslational modification] 881621007511 similar to aspartate kinase, N-terminal part 881621007512 similar to aspartate kinase, central part 881621007513 similar to aspartate kinase, C-terminal part 881621007514 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 881621007515 active site 881621007516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007518 putative substrate translocation pore; other site 881621007519 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 881621007520 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 881621007521 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 881621007522 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 881621007523 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 881621007524 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 881621007525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 881621007526 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 881621007527 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 881621007528 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 881621007529 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 881621007530 CoenzymeA binding site [chemical binding]; other site 881621007531 subunit interaction site [polypeptide binding]; other site 881621007532 PHB binding site; other site 881621007533 Divergent PAP2 family; Region: DUF212; pfam02681 881621007534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007536 active site 881621007537 catalytic tetrad [active] 881621007538 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 881621007539 Cl- selectivity filter; other site 881621007540 Cl- binding residues [ion binding]; other site 881621007541 pore gating glutamate residue; other site 881621007542 dimer interface [polypeptide binding]; other site 881621007543 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621007544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 881621007545 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621007546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007547 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621007548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621007549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007550 hypothetical protein; Provisional; Region: PRK13669 881621007551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 881621007552 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 881621007553 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621007554 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621007555 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621007556 Transporter associated domain; Region: CorC_HlyC; smart01091 881621007557 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621007558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007559 Coenzyme A binding pocket [chemical binding]; other site 881621007560 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 881621007561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007562 active site 881621007563 motif I; other site 881621007564 motif II; other site 881621007565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007566 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 881621007567 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621007568 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 881621007569 active site 881621007570 metal binding site [ion binding]; metal-binding site 881621007571 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621007572 Predicted permeases [General function prediction only]; Region: COG0730 881621007573 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 881621007574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621007575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007576 active site 881621007577 catalytic tetrad [active] 881621007578 Uncharacterized conserved protein [Function unknown]; Region: COG1801 881621007579 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 881621007580 FeS assembly protein SufB; Region: sufB; TIGR01980 881621007581 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 881621007582 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 881621007583 trimerization site [polypeptide binding]; other site 881621007584 active site 881621007585 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621007586 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 881621007587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621007588 catalytic residue [active] 881621007589 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 881621007590 FeS assembly protein SufD; Region: sufD; TIGR01981 881621007591 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 881621007592 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 881621007593 Walker A/P-loop; other site 881621007594 ATP binding site [chemical binding]; other site 881621007595 Q-loop/lid; other site 881621007596 ABC transporter signature motif; other site 881621007597 Walker B; other site 881621007598 D-loop; other site 881621007599 H-loop/switch region; other site 881621007600 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 881621007601 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 881621007602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007603 ABC-ATPase subunit interface; other site 881621007604 putative PBP binding loops; other site 881621007605 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 881621007606 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 881621007607 Walker A/P-loop; other site 881621007608 ATP binding site [chemical binding]; other site 881621007609 Q-loop/lid; other site 881621007610 ABC transporter signature motif; other site 881621007611 Walker B; other site 881621007612 D-loop; other site 881621007613 H-loop/switch region; other site 881621007614 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 881621007615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 881621007616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621007617 dimer interface [polypeptide binding]; other site 881621007618 phosphorylation site [posttranslational modification] 881621007619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007620 ATP binding site [chemical binding]; other site 881621007621 Mg2+ binding site [ion binding]; other site 881621007622 G-X-G motif; other site 881621007623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007625 active site 881621007626 phosphorylation site [posttranslational modification] 881621007627 intermolecular recognition site; other site 881621007628 dimerization interface [polypeptide binding]; other site 881621007629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621007630 DNA binding site [nucleotide binding] 881621007631 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007632 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 881621007633 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621007634 catalytic residues [active] 881621007635 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 881621007636 lipoyl attachment site [posttranslational modification]; other site 881621007637 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 881621007638 ArsC family; Region: ArsC; pfam03960 881621007639 putative ArsC-like catalytic residues; other site 881621007640 putative TRX-like catalytic residues [active] 881621007641 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 881621007642 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 881621007643 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621007644 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621007645 Walker A/P-loop; other site 881621007646 ATP binding site [chemical binding]; other site 881621007647 Q-loop/lid; other site 881621007648 ABC transporter signature motif; other site 881621007649 Walker B; other site 881621007650 D-loop; other site 881621007651 H-loop/switch region; other site 881621007652 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 881621007653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 881621007654 ABC-ATPase subunit interface; other site 881621007655 dimer interface [polypeptide binding]; other site 881621007656 putative PBP binding regions; other site 881621007657 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621007658 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 881621007659 intersubunit interface [polypeptide binding]; other site 881621007660 Predicted esterase [General function prediction only]; Region: COG0627 881621007661 S-formylglutathione hydrolase; Region: PLN02442 881621007662 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621007663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007664 catalytic residue [active] 881621007665 SdpI/YhfL protein family; Region: SdpI; pfam13630 881621007666 CAT RNA binding domain; Region: CAT_RBD; smart01061 881621007667 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621007668 PRD domain; Region: PRD; pfam00874 881621007669 PRD domain; Region: PRD; pfam00874 881621007670 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 881621007671 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 881621007672 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621007673 truncated, c-terminal part 881621007674 truncated, N-terminal part 881621007675 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621007676 HTH domain; Region: HTH_11; pfam08279 881621007677 WYL domain; Region: WYL; pfam13280 881621007678 Uncharacterized conserved protein [Function unknown]; Region: COG1434 881621007679 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621007680 putative active site [active] 881621007681 similar to glycosidase, C-terminal part 881621007682 similar to glycosidase, N-terminal part 881621007683 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007684 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 881621007685 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621007686 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 881621007687 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 881621007688 active site 881621007689 catalytic site [active] 881621007690 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 881621007691 putative metal binding site [ion binding]; other site 881621007692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621007693 non-specific DNA binding site [nucleotide binding]; other site 881621007694 salt bridge; other site 881621007695 sequence-specific DNA binding site [nucleotide binding]; other site 881621007696 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 881621007697 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 881621007698 SmpB-tmRNA interface; other site 881621007699 ribonuclease R; Region: RNase_R; TIGR02063 881621007700 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 881621007701 RNB domain; Region: RNB; pfam00773 881621007702 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 881621007703 RNA binding site [nucleotide binding]; other site 881621007704 Esterase/lipase [General function prediction only]; Region: COG1647 881621007705 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621007706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 881621007707 Esterase/lipase [General function prediction only]; Region: COG1647 881621007708 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 881621007709 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 881621007710 PGAP1-like protein; Region: PGAP1; pfam07819 881621007711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621007712 enolase; Provisional; Region: eno; PRK00077 881621007713 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 881621007714 dimer interface [polypeptide binding]; other site 881621007715 metal binding site [ion binding]; metal-binding site 881621007716 substrate binding pocket [chemical binding]; other site 881621007717 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 881621007718 phosphoglyceromutase; Provisional; Region: PRK05434 881621007719 triosephosphate isomerase; Provisional; Region: PRK14567 881621007720 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 881621007721 substrate binding site [chemical binding]; other site 881621007722 dimer interface [polypeptide binding]; other site 881621007723 catalytic triad [active] 881621007724 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 881621007725 Phosphoglycerate kinase; Region: PGK; pfam00162 881621007726 substrate binding site [chemical binding]; other site 881621007727 hinge regions; other site 881621007728 ADP binding site [chemical binding]; other site 881621007729 catalytic site [active] 881621007730 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 881621007731 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 881621007732 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 881621007733 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621007734 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621007735 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 881621007736 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 881621007737 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 881621007738 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621007739 DNA binding site [nucleotide binding] 881621007740 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 881621007741 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 881621007742 active site 881621007743 dimer interface [polypeptide binding]; other site 881621007744 MMPL family; Region: MMPL; pfam03176 881621007745 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 881621007746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621007748 putative DNA binding site [nucleotide binding]; other site 881621007749 putative Zn2+ binding site [ion binding]; other site 881621007750 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 881621007751 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007752 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007753 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007754 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007755 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621007756 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 881621007757 similar to internalin B and to Ami protein,partial 881621007758 similar to chitinase and chitin binding protein,C-terminal part 881621007759 similar to chitinase and chitin binding protein,N-terminal part 881621007760 Clp protease; Region: CLP_protease; pfam00574 881621007761 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621007762 oligomer interface [polypeptide binding]; other site 881621007763 active site residues [active] 881621007764 amino acid transporter; Region: 2A0306; TIGR00909 881621007765 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 881621007766 similar to putative peptidoglycan linked protein (LPXTG motif), partial 881621007767 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 881621007768 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 881621007769 active site 881621007770 FMN binding site [chemical binding]; other site 881621007771 substrate binding site [chemical binding]; other site 881621007772 homotetramer interface [polypeptide binding]; other site 881621007773 catalytic residue [active] 881621007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 881621007775 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 881621007776 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 881621007777 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 881621007778 phosphate binding site [ion binding]; other site 881621007779 putative substrate binding pocket [chemical binding]; other site 881621007780 dimer interface [polypeptide binding]; other site 881621007781 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 881621007782 AAA domain; Region: AAA_18; pfam13238 881621007783 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 881621007784 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 881621007785 active site 881621007786 substrate binding site [chemical binding]; other site 881621007787 metal binding site [ion binding]; metal-binding site 881621007788 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 881621007789 active site 881621007790 catalytic residues [active] 881621007791 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 881621007792 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 881621007793 NAD binding site [chemical binding]; other site 881621007794 homodimer interface [polypeptide binding]; other site 881621007795 active site 881621007796 substrate binding site [chemical binding]; other site 881621007797 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 881621007798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 881621007799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621007800 TPR repeat; Region: TPR_11; pfam13414 881621007801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621007802 binding surface 881621007803 TPR motif; other site 881621007804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 881621007805 binding surface 881621007806 TPR motif; other site 881621007807 similar to repressor protein 881621007808 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 881621007809 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 881621007810 trimer interface [polypeptide binding]; other site 881621007811 active site 881621007812 substrate binding site [chemical binding]; other site 881621007813 CoA binding site [chemical binding]; other site 881621007814 pyrophosphatase PpaX; Provisional; Region: PRK13288 881621007815 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 881621007816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621007817 motif II; other site 881621007818 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 881621007819 HPr kinase/phosphorylase; Provisional; Region: PRK05428 881621007820 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 881621007821 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 881621007822 Hpr binding site; other site 881621007823 active site 881621007824 homohexamer subunit interaction site [polypeptide binding]; other site 881621007825 Predicted membrane protein [Function unknown]; Region: COG1950 881621007826 PspC domain; Region: PspC; pfam04024 881621007827 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 881621007828 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007829 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621007830 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007831 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 881621007832 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 881621007833 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 881621007834 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 881621007835 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 881621007836 excinuclease ABC subunit B; Provisional; Region: PRK05298 881621007837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007838 ATP binding site [chemical binding]; other site 881621007839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007840 nucleotide binding region [chemical binding]; other site 881621007841 ATP-binding site [chemical binding]; other site 881621007842 Ultra-violet resistance protein B; Region: UvrB; pfam12344 881621007843 UvrB/uvrC motif; Region: UVR; pfam02151 881621007844 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 881621007845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621007846 Zn2+ binding site [ion binding]; other site 881621007847 Mg2+ binding site [ion binding]; other site 881621007848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621007849 dimerization interface [polypeptide binding]; other site 881621007850 putative DNA binding site [nucleotide binding]; other site 881621007851 putative Zn2+ binding site [ion binding]; other site 881621007852 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 881621007853 PhoU domain; Region: PhoU; pfam01895 881621007854 PhoU domain; Region: PhoU; pfam01895 881621007855 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 881621007856 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 881621007857 Walker A/P-loop; other site 881621007858 ATP binding site [chemical binding]; other site 881621007859 Q-loop/lid; other site 881621007860 ABC transporter signature motif; other site 881621007861 Walker B; other site 881621007862 D-loop; other site 881621007863 H-loop/switch region; other site 881621007864 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 881621007865 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 881621007866 Walker A/P-loop; other site 881621007867 ATP binding site [chemical binding]; other site 881621007868 Q-loop/lid; other site 881621007869 ABC transporter signature motif; other site 881621007870 Walker B; other site 881621007871 D-loop; other site 881621007872 H-loop/switch region; other site 881621007873 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 881621007874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007875 dimer interface [polypeptide binding]; other site 881621007876 conserved gate region; other site 881621007877 putative PBP binding loops; other site 881621007878 ABC-ATPase subunit interface; other site 881621007879 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 881621007880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621007881 dimer interface [polypeptide binding]; other site 881621007882 conserved gate region; other site 881621007883 putative PBP binding loops; other site 881621007884 ABC-ATPase subunit interface; other site 881621007885 PBP superfamily domain; Region: PBP_like_2; cl17296 881621007886 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 881621007887 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 881621007888 HAMP domain; Region: HAMP; pfam00672 881621007889 dimerization interface [polypeptide binding]; other site 881621007890 PAS domain; Region: PAS; smart00091 881621007891 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 881621007892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621007893 dimer interface [polypeptide binding]; other site 881621007894 phosphorylation site [posttranslational modification] 881621007895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007896 ATP binding site [chemical binding]; other site 881621007897 Mg2+ binding site [ion binding]; other site 881621007898 G-X-G motif; other site 881621007899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007901 active site 881621007902 phosphorylation site [posttranslational modification] 881621007903 intermolecular recognition site; other site 881621007904 dimerization interface [polypeptide binding]; other site 881621007905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621007906 DNA binding site [nucleotide binding] 881621007907 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 881621007908 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 881621007909 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 881621007910 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 881621007911 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621007912 putative active site [active] 881621007913 catalytic site [active] 881621007914 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621007915 putative active site [active] 881621007916 catalytic site [active] 881621007917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007918 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 881621007919 Peptidase family M23; Region: Peptidase_M23; pfam01551 881621007920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007921 NlpC/P60 family; Region: NLPC_P60; pfam00877 881621007922 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 881621007923 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 881621007924 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 881621007925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621007926 Walker A/P-loop; other site 881621007927 ATP binding site [chemical binding]; other site 881621007928 Q-loop/lid; other site 881621007929 ABC transporter signature motif; other site 881621007930 Walker B; other site 881621007931 D-loop; other site 881621007932 H-loop/switch region; other site 881621007933 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621007934 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007935 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007936 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 881621007937 peptide chain release factor 2; Validated; Region: prfB; PRK00578 881621007938 This domain is found in peptide chain release factors; Region: PCRF; smart00937 881621007939 RF-1 domain; Region: RF-1; pfam00472 881621007940 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 881621007941 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 881621007942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 881621007943 nucleotide binding region [chemical binding]; other site 881621007944 ATP-binding site [chemical binding]; other site 881621007945 SEC-C motif; Region: SEC-C; pfam02810 881621007946 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 881621007947 30S subunit binding site; other site 881621007948 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 881621007949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621007950 active site 881621007951 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 881621007952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007953 ATP binding site [chemical binding]; other site 881621007954 putative Mg++ binding site [ion binding]; other site 881621007955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007956 nucleotide binding region [chemical binding]; other site 881621007957 ATP-binding site [chemical binding]; other site 881621007958 EDD domain protein, DegV family; Region: DegV; TIGR00762 881621007959 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 881621007960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621007961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621007962 active site 881621007963 phosphorylation site [posttranslational modification] 881621007964 intermolecular recognition site; other site 881621007965 dimerization interface [polypeptide binding]; other site 881621007966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 881621007967 DNA binding residues [nucleotide binding] 881621007968 dimerization interface [polypeptide binding]; other site 881621007969 Uncharacterized conserved protein [Function unknown]; Region: COG1739 881621007970 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 881621007971 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 881621007972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 881621007973 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 881621007974 Transcriptional regulator [Transcription]; Region: LytR; COG1316 881621007975 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 881621007976 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621007977 Mg++ binding site [ion binding]; other site 881621007978 putative catalytic motif [active] 881621007979 substrate binding site [chemical binding]; other site 881621007980 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 881621007981 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 881621007982 active site 881621007983 octamer interface [polypeptide binding]; other site 881621007984 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 881621007985 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 881621007986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621007987 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621007988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 881621007989 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 881621007990 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621007991 dimer interface [polypeptide binding]; other site 881621007992 ssDNA binding site [nucleotide binding]; other site 881621007993 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621007994 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 881621007995 rod shape-determining protein Mbl; Provisional; Region: PRK13928 881621007996 MreB and similar proteins; Region: MreB_like; cd10225 881621007997 nucleotide binding site [chemical binding]; other site 881621007998 Mg binding site [ion binding]; other site 881621007999 putative protofilament interaction site [polypeptide binding]; other site 881621008000 RodZ interaction site [polypeptide binding]; other site 881621008001 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 881621008002 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621008003 hinge; other site 881621008004 active site 881621008005 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 881621008006 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 881621008007 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 881621008008 gamma subunit interface [polypeptide binding]; other site 881621008009 epsilon subunit interface [polypeptide binding]; other site 881621008010 LBP interface [polypeptide binding]; other site 881621008011 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 881621008012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 881621008013 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 881621008014 alpha subunit interaction interface [polypeptide binding]; other site 881621008015 Walker A motif; other site 881621008016 ATP binding site [chemical binding]; other site 881621008017 Walker B motif; other site 881621008018 inhibitor binding site; inhibition site 881621008019 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621008020 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 881621008021 core domain interface [polypeptide binding]; other site 881621008022 delta subunit interface [polypeptide binding]; other site 881621008023 epsilon subunit interface [polypeptide binding]; other site 881621008024 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 881621008025 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 881621008026 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 881621008027 beta subunit interaction interface [polypeptide binding]; other site 881621008028 Walker A motif; other site 881621008029 ATP binding site [chemical binding]; other site 881621008030 Walker B motif; other site 881621008031 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621008032 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 881621008033 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 881621008034 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 881621008035 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 881621008036 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 881621008037 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 881621008038 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 881621008039 ATP synthase I chain; Region: ATP_synt_I; pfam03899 881621008040 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 881621008041 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 881621008042 active site 881621008043 homodimer interface [polypeptide binding]; other site 881621008044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 881621008045 active site 881621008046 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 881621008047 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 881621008048 dimer interface [polypeptide binding]; other site 881621008049 active site 881621008050 glycine-pyridoxal phosphate binding site [chemical binding]; other site 881621008051 folate binding site [chemical binding]; other site 881621008052 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621008053 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 881621008054 active site 881621008055 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 881621008056 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 881621008057 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 881621008058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621008059 S-adenosylmethionine binding site [chemical binding]; other site 881621008060 peptide chain release factor 1; Validated; Region: prfA; PRK00591 881621008061 This domain is found in peptide chain release factors; Region: PCRF; smart00937 881621008062 RF-1 domain; Region: RF-1; pfam00472 881621008063 thymidine kinase; Provisional; Region: PRK04296 881621008064 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 881621008065 ATP binding site [chemical binding]; other site 881621008066 Walker A motif; other site 881621008067 Walker B motif; other site 881621008068 homoserine kinase; Provisional; Region: PRK01212 881621008069 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 881621008070 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621008071 threonine synthase; Reviewed; Region: PRK06721 881621008072 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 881621008073 homodimer interface [polypeptide binding]; other site 881621008074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008075 catalytic residue [active] 881621008076 homoserine dehydrogenase; Provisional; Region: PRK06349 881621008077 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 881621008078 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 881621008079 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 881621008080 similar to transcription regulator MerR family,partial, C-terminal part 881621008081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621008082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008083 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 881621008084 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 881621008085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621008086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 881621008087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621008088 dimerization interface [polypeptide binding]; other site 881621008089 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 881621008090 Predicted membrane protein [Function unknown]; Region: COG2246 881621008091 GtrA-like protein; Region: GtrA; pfam04138 881621008092 transcription termination factor Rho; Provisional; Region: rho; PRK09376 881621008093 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 881621008094 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 881621008095 RNA binding site [nucleotide binding]; other site 881621008096 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 881621008097 multimer interface [polypeptide binding]; other site 881621008098 Walker A motif; other site 881621008099 ATP binding site [chemical binding]; other site 881621008100 Walker B motif; other site 881621008101 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 881621008102 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621008103 hinge; other site 881621008104 active site 881621008105 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621008106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008107 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 881621008108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008109 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 881621008110 putative ADP-binding pocket [chemical binding]; other site 881621008111 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 881621008112 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 881621008113 intersubunit interface [polypeptide binding]; other site 881621008114 active site 881621008115 zinc binding site [ion binding]; other site 881621008116 Na+ binding site [ion binding]; other site 881621008117 putative lipid kinase; Reviewed; Region: PRK13055 881621008118 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 881621008119 CTP synthetase; Validated; Region: pyrG; PRK05380 881621008120 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 881621008121 Catalytic site [active] 881621008122 active site 881621008123 UTP binding site [chemical binding]; other site 881621008124 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 881621008125 active site 881621008126 putative oxyanion hole; other site 881621008127 catalytic triad [active] 881621008128 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 881621008129 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 881621008130 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 881621008131 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 881621008132 active site 881621008133 HIGH motif; other site 881621008134 KMSK motif region; other site 881621008135 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 881621008136 tRNA binding surface [nucleotide binding]; other site 881621008137 anticodon binding site; other site 881621008138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 881621008139 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 881621008140 Peptidase family M50; Region: Peptidase_M50; pfam02163 881621008141 active site 881621008142 putative substrate binding region [chemical binding]; other site 881621008143 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 881621008144 active site 1 [active] 881621008145 dimer interface [polypeptide binding]; other site 881621008146 hexamer interface [polypeptide binding]; other site 881621008147 active site 2 [active] 881621008148 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 881621008149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621008150 Zn2+ binding site [ion binding]; other site 881621008151 Mg2+ binding site [ion binding]; other site 881621008152 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 881621008153 conserved hypothetical protein TIGR01655; Region: yxeA_fam 881621008154 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621008155 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621008156 peptide binding site [polypeptide binding]; other site 881621008157 Predicted integral membrane protein [Function unknown]; Region: COG5658 881621008158 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 881621008159 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 881621008160 catalytic triad [active] 881621008161 metal binding site [ion binding]; metal-binding site 881621008162 conserved cis-peptide bond; other site 881621008163 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 881621008164 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 881621008165 folate binding site [chemical binding]; other site 881621008166 NADP+ binding site [chemical binding]; other site 881621008167 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 881621008168 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 881621008169 putative NAD(P) binding site [chemical binding]; other site 881621008170 dimer interface [polypeptide binding]; other site 881621008171 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 881621008172 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621008173 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621008174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008175 active site 881621008176 motif I; other site 881621008177 motif II; other site 881621008178 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 881621008179 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 881621008180 Uncharacterized conserved protein [Function unknown]; Region: COG1359 881621008181 Predicted transcriptional regulators [Transcription]; Region: COG1733 881621008182 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 881621008183 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 881621008184 Uncharacterized conserved protein [Function unknown]; Region: COG2427 881621008185 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 881621008186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 881621008187 catalytic loop [active] 881621008188 iron binding site [ion binding]; other site 881621008189 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 881621008190 4Fe-4S binding domain; Region: Fer4; pfam00037 881621008191 4Fe-4S binding domain; Region: Fer4; pfam00037 881621008192 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 881621008193 [4Fe-4S] binding site [ion binding]; other site 881621008194 molybdopterin cofactor binding site; other site 881621008195 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 881621008196 molybdopterin cofactor binding site; other site 881621008197 Uncharacterized conserved protein [Function unknown]; Region: COG1912 881621008198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621008200 putative substrate translocation pore; other site 881621008201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621008203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621008204 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621008205 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621008206 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621008207 Leucine-rich repeats; other site 881621008208 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008209 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008210 LRR adjacent; Region: LRR_adjacent; pfam08191 881621008211 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621008212 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008213 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621008214 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008215 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008216 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621008217 LRR adjacent; Region: LRR_adjacent; pfam08191 881621008218 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 881621008219 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 881621008220 Walker A motif; other site 881621008221 similar to putative endo-beta-N-acetylglucosaminidase, pseudogene, internal part 881621008222 similar to putative endo-beta-N-acetylglucosaminidase, N-terminal part 881621008223 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 881621008224 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 881621008225 23S rRNA interface [nucleotide binding]; other site 881621008226 L3 interface [polypeptide binding]; other site 881621008227 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 881621008228 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 881621008229 dimerization interface 3.5A [polypeptide binding]; other site 881621008230 active site 881621008231 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 881621008232 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 881621008233 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008234 Walker A/P-loop; other site 881621008235 ATP binding site [chemical binding]; other site 881621008236 Q-loop/lid; other site 881621008237 ABC transporter signature motif; other site 881621008238 Walker B; other site 881621008239 D-loop; other site 881621008240 H-loop/switch region; other site 881621008241 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 881621008242 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008243 Walker A/P-loop; other site 881621008244 ATP binding site [chemical binding]; other site 881621008245 Q-loop/lid; other site 881621008246 ABC transporter signature motif; other site 881621008247 Walker B; other site 881621008248 D-loop; other site 881621008249 H-loop/switch region; other site 881621008250 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 881621008251 MgtC family; Region: MgtC; pfam02308 881621008252 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 881621008253 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 881621008254 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 881621008255 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 881621008256 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 881621008257 alphaNTD - beta interaction site [polypeptide binding]; other site 881621008258 alphaNTD homodimer interface [polypeptide binding]; other site 881621008259 alphaNTD - beta' interaction site [polypeptide binding]; other site 881621008260 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 881621008261 30S ribosomal protein S11; Validated; Region: PRK05309 881621008262 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 881621008263 30S ribosomal protein S13; Region: bact_S13; TIGR03631 881621008264 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 881621008265 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 881621008266 rRNA binding site [nucleotide binding]; other site 881621008267 predicted 30S ribosome binding site; other site 881621008268 adenylate kinase; Reviewed; Region: adk; PRK00279 881621008269 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 881621008270 AMP-binding site [chemical binding]; other site 881621008271 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 881621008272 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 881621008273 SecY translocase; Region: SecY; pfam00344 881621008274 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 881621008275 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 881621008276 23S rRNA binding site [nucleotide binding]; other site 881621008277 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 881621008278 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 881621008279 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 881621008280 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 881621008281 5S rRNA interface [nucleotide binding]; other site 881621008282 L27 interface [polypeptide binding]; other site 881621008283 23S rRNA interface [nucleotide binding]; other site 881621008284 L5 interface [polypeptide binding]; other site 881621008285 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 881621008286 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621008287 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621008288 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 881621008289 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 881621008290 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 881621008291 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 881621008292 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 881621008293 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 881621008294 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 881621008295 RNA binding site [nucleotide binding]; other site 881621008296 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 881621008297 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 881621008298 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 881621008299 23S rRNA interface [nucleotide binding]; other site 881621008300 putative translocon interaction site; other site 881621008301 signal recognition particle (SRP54) interaction site; other site 881621008302 L23 interface [polypeptide binding]; other site 881621008303 trigger factor interaction site; other site 881621008304 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 881621008305 23S rRNA interface [nucleotide binding]; other site 881621008306 5S rRNA interface [nucleotide binding]; other site 881621008307 putative antibiotic binding site [chemical binding]; other site 881621008308 L25 interface [polypeptide binding]; other site 881621008309 L27 interface [polypeptide binding]; other site 881621008310 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 881621008311 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 881621008312 G-X-X-G motif; other site 881621008313 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 881621008314 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 881621008315 putative translocon binding site; other site 881621008316 protein-rRNA interface [nucleotide binding]; other site 881621008317 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 881621008318 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 881621008319 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 881621008320 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 881621008321 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 881621008322 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 881621008323 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 881621008324 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 881621008325 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 881621008326 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 881621008327 UbiA prenyltransferase family; Region: UbiA; pfam01040 881621008328 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 881621008329 ApbE family; Region: ApbE; pfam02424 881621008330 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621008331 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 881621008332 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621008333 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 881621008334 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621008335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 881621008336 Predicted membrane protein [Function unknown]; Region: COG2259 881621008337 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621008338 trimer interface [polypeptide binding]; other site 881621008339 Predicted membrane protein [Function unknown]; Region: COG4769 881621008340 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621008341 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621008342 substrate binding pocket [chemical binding]; other site 881621008343 chain length determination region; other site 881621008344 substrate-Mg2+ binding site; other site 881621008345 catalytic residues [active] 881621008346 aspartate-rich region 1; other site 881621008347 active site lid residues [active] 881621008348 aspartate-rich region 2; other site 881621008349 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 881621008350 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 881621008351 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 881621008352 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 881621008353 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 881621008354 hypothetical protein; Provisional; Region: PRK02947 881621008355 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008356 putative active site [active] 881621008357 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 881621008358 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 881621008359 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 881621008360 active site 881621008361 substrate binding pocket [chemical binding]; other site 881621008362 homodimer interaction site [polypeptide binding]; other site 881621008363 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 881621008364 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 881621008365 active site 881621008366 P-loop; other site 881621008367 phosphorylation site [posttranslational modification] 881621008368 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008369 active site 881621008370 phosphorylation site [posttranslational modification] 881621008371 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621008372 Mga helix-turn-helix domain; Region: Mga; pfam05043 881621008373 PRD domain; Region: PRD; pfam00874 881621008374 PRD domain; Region: PRD; pfam00874 881621008375 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621008376 active site 881621008377 P-loop; other site 881621008378 phosphorylation site [posttranslational modification] 881621008379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008380 active site 881621008381 phosphorylation site [posttranslational modification] 881621008382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621008383 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621008384 Walker A/P-loop; other site 881621008385 ATP binding site [chemical binding]; other site 881621008386 Q-loop/lid; other site 881621008387 ABC transporter signature motif; other site 881621008388 Walker B; other site 881621008389 D-loop; other site 881621008390 H-loop/switch region; other site 881621008391 elongation factor Tu; Reviewed; Region: PRK00049 881621008392 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 881621008393 G1 box; other site 881621008394 GEF interaction site [polypeptide binding]; other site 881621008395 GTP/Mg2+ binding site [chemical binding]; other site 881621008396 Switch I region; other site 881621008397 G2 box; other site 881621008398 G3 box; other site 881621008399 Switch II region; other site 881621008400 G4 box; other site 881621008401 G5 box; other site 881621008402 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 881621008403 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 881621008404 Antibiotic Binding Site [chemical binding]; other site 881621008405 elongation factor G; Reviewed; Region: PRK00007 881621008406 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 881621008407 G1 box; other site 881621008408 putative GEF interaction site [polypeptide binding]; other site 881621008409 GTP/Mg2+ binding site [chemical binding]; other site 881621008410 Switch I region; other site 881621008411 G2 box; other site 881621008412 G3 box; other site 881621008413 Switch II region; other site 881621008414 G4 box; other site 881621008415 G5 box; other site 881621008416 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 881621008417 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 881621008418 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 881621008419 30S ribosomal protein S7; Validated; Region: PRK05302 881621008420 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 881621008421 S17 interaction site [polypeptide binding]; other site 881621008422 S8 interaction site; other site 881621008423 16S rRNA interaction site [nucleotide binding]; other site 881621008424 streptomycin interaction site [chemical binding]; other site 881621008425 23S rRNA interaction site [nucleotide binding]; other site 881621008426 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 881621008427 similar to deoxyguanosinetriphosphate triphosphohydrolase, N-terminal part 881621008428 similar to deoxyguanosinetriphosphate triphosphohydrolase, C-terminal part 881621008429 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 881621008430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621008431 Zn2+ binding site [ion binding]; other site 881621008432 Mg2+ binding site [ion binding]; other site 881621008433 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 881621008434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621008435 Coenzyme A binding pocket [chemical binding]; other site 881621008436 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 881621008437 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621008438 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 881621008439 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621008440 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 881621008441 Substrate binding site [chemical binding]; other site 881621008442 Leucine rich repeat; Region: LRR_8; pfam13855 881621008443 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621008444 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621008445 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621008446 substrate binding site [chemical binding]; other site 881621008447 hexamer interface [polypeptide binding]; other site 881621008448 metal binding site [ion binding]; metal-binding site 881621008449 similar to transketolase, C-terminal part 881621008450 similar to transketolase, N-terminal part 881621008451 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621008452 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 881621008453 substrate binding site [chemical binding]; other site 881621008454 hexamer interface [polypeptide binding]; other site 881621008455 metal binding site [ion binding]; metal-binding site 881621008456 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 881621008457 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008458 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 881621008459 putative NAD(P) binding site [chemical binding]; other site 881621008460 catalytic Zn binding site [ion binding]; other site 881621008461 structural Zn binding site [ion binding]; other site 881621008462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008463 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621008464 putative NAD(P) binding site [chemical binding]; other site 881621008465 catalytic Zn binding site [ion binding]; other site 881621008466 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 881621008467 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621008468 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621008469 active site 881621008470 P-loop; other site 881621008471 phosphorylation site [posttranslational modification] 881621008472 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008473 active site 881621008474 phosphorylation site [posttranslational modification] 881621008475 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621008476 PRD domain; Region: PRD; pfam00874 881621008477 PRD domain; Region: PRD; pfam00874 881621008478 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621008479 active site 881621008480 P-loop; other site 881621008481 phosphorylation site [posttranslational modification] 881621008482 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621008483 active site 881621008484 phosphorylation site [posttranslational modification] 881621008485 Predicted membrane protein [Function unknown]; Region: COG4905 881621008486 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 881621008487 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 881621008488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 881621008489 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621008490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 881621008491 active site 881621008492 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621008493 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621008494 Ligand Binding Site [chemical binding]; other site 881621008495 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 881621008496 Similar to UV-damage repair protein, truncated, in frame stop codon 881621008497 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621008498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621008499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 881621008500 active site 881621008501 phosphorylation site [posttranslational modification] 881621008502 intermolecular recognition site; other site 881621008503 dimerization interface [polypeptide binding]; other site 881621008504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 881621008505 DNA binding site [nucleotide binding] 881621008506 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 881621008507 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 881621008508 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 881621008509 Ligand Binding Site [chemical binding]; other site 881621008510 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 881621008511 GAF domain; Region: GAF_3; pfam13492 881621008512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 881621008513 dimer interface [polypeptide binding]; other site 881621008514 phosphorylation site [posttranslational modification] 881621008515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621008516 ATP binding site [chemical binding]; other site 881621008517 Mg2+ binding site [ion binding]; other site 881621008518 G-X-G motif; other site 881621008519 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 881621008520 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 881621008521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621008522 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 881621008523 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008524 active site 881621008525 P-loop; other site 881621008526 phosphorylation site [posttranslational modification] 881621008527 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621008528 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008529 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008530 methionine cluster; other site 881621008531 active site 881621008532 phosphorylation site [posttranslational modification] 881621008533 metal binding site [ion binding]; metal-binding site 881621008534 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 881621008535 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 881621008536 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 881621008537 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 881621008538 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621008539 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 881621008540 Soluble P-type ATPase [General function prediction only]; Region: COG4087 881621008541 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621008542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621008543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621008544 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 881621008545 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621008546 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621008547 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 881621008548 Protein of unknown function (DUF970); Region: DUF970; pfam06153 881621008549 thymidylate kinase; Validated; Region: tmk; PRK00698 881621008550 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 881621008551 TMP-binding site; other site 881621008552 ATP-binding site [chemical binding]; other site 881621008553 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 881621008554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621008555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621008556 catalytic residue [active] 881621008557 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 881621008558 similar to unknown protein, truncated (pseudogene) 881621008559 similar to transposase, pseudogene 881621008560 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 881621008561 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 881621008562 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 881621008563 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 881621008564 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 881621008565 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008566 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008567 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008568 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008569 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008570 putative active site [active] 881621008571 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621008572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008573 active site 881621008574 motif I; other site 881621008575 motif II; other site 881621008576 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 881621008577 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 881621008578 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 881621008579 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 881621008580 putative trimer interface [polypeptide binding]; other site 881621008581 putative CoA binding site [chemical binding]; other site 881621008582 von Willebrand factor type A domain; Region: VWA_2; pfam13519 881621008583 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008584 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008585 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008586 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 881621008587 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 881621008588 inhibitor-cofactor binding pocket; inhibition site 881621008589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008590 catalytic residue [active] 881621008591 Bacterial sugar transferase; Region: Bac_transf; pfam02397 881621008592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008593 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 881621008594 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008595 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 881621008596 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 881621008597 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 881621008598 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 881621008599 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 881621008600 NAD binding site [chemical binding]; other site 881621008601 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 881621008602 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 881621008603 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 881621008604 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 881621008605 NAD(P) binding site [chemical binding]; other site 881621008606 homodimer interface [polypeptide binding]; other site 881621008607 substrate binding site [chemical binding]; other site 881621008608 active site 881621008609 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 881621008610 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 881621008611 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 881621008612 Chain length determinant protein; Region: Wzz; cl15801 881621008613 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 881621008614 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 881621008615 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621008616 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 881621008617 ligand binding site [chemical binding]; other site 881621008618 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621008619 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 881621008620 nudix motif; other site 881621008621 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 881621008622 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621008623 active site 881621008624 catalytic tetrad [active] 881621008625 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008626 active site 881621008627 methionine cluster; other site 881621008628 phosphorylation site [posttranslational modification] 881621008629 metal binding site [ion binding]; metal-binding site 881621008630 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621008631 beta-galactosidase; Region: BGL; TIGR03356 881621008632 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 881621008633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008634 active site 881621008635 motif I; other site 881621008636 motif II; other site 881621008637 similar to glycosyl hydrolase, internal part 881621008638 similar to glycosyl hydrolase, N-terminal part 881621008639 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621008640 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008641 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008642 active site 881621008643 P-loop; other site 881621008644 phosphorylation site [posttranslational modification] 881621008645 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621008646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621008647 DNA-binding site [nucleotide binding]; DNA binding site 881621008648 UTRA domain; Region: UTRA; pfam07702 881621008649 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 881621008650 recombination protein RecR; Reviewed; Region: recR; PRK00076 881621008651 RecR protein; Region: RecR; pfam02132 881621008652 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 881621008653 putative active site [active] 881621008654 putative metal-binding site [ion binding]; other site 881621008655 tetramer interface [polypeptide binding]; other site 881621008656 hypothetical protein; Validated; Region: PRK00153 881621008657 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 881621008658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 881621008659 Walker A motif; other site 881621008660 ATP binding site [chemical binding]; other site 881621008661 Walker B motif; other site 881621008662 arginine finger; other site 881621008663 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 881621008664 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 881621008665 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008666 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621008667 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 881621008668 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 881621008669 N- and C-terminal domain interface [polypeptide binding]; other site 881621008670 active site 881621008671 catalytic site [active] 881621008672 metal binding site [ion binding]; metal-binding site 881621008673 carbohydrate binding site [chemical binding]; other site 881621008674 ATP binding site [chemical binding]; other site 881621008675 SH3-like domain; Region: SH3_8; pfam13457 881621008676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 881621008677 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 881621008678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621008679 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 881621008680 Walker A/P-loop; other site 881621008681 ATP binding site [chemical binding]; other site 881621008682 Q-loop/lid; other site 881621008683 ABC transporter signature motif; other site 881621008684 Walker B; other site 881621008685 D-loop; other site 881621008686 H-loop/switch region; other site 881621008687 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621008688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621008689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621008690 Walker A/P-loop; other site 881621008691 ATP binding site [chemical binding]; other site 881621008692 Q-loop/lid; other site 881621008693 ABC transporter signature motif; other site 881621008694 Walker B; other site 881621008695 D-loop; other site 881621008696 H-loop/switch region; other site 881621008697 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 881621008698 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 881621008699 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 881621008700 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 881621008701 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 881621008702 nucleoside/Zn binding site; other site 881621008703 dimer interface [polypeptide binding]; other site 881621008704 catalytic motif [active] 881621008705 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621008706 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 881621008707 active site 881621008708 acyl-activating enzyme (AAE) consensus motif; other site 881621008709 putative CoA binding site [chemical binding]; other site 881621008710 AMP binding site [chemical binding]; other site 881621008711 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 881621008712 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 881621008713 active site 881621008714 trimer interface [polypeptide binding]; other site 881621008715 allosteric site; other site 881621008716 active site lid [active] 881621008717 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621008718 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008719 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 881621008720 DNA binding residues [nucleotide binding] 881621008721 drug binding residues [chemical binding]; other site 881621008722 dimer interface [polypeptide binding]; other site 881621008723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 881621008724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 881621008725 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621008726 dimer interface [polypeptide binding]; other site 881621008727 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621008728 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 881621008729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 881621008730 MarR family; Region: MarR; pfam01047 881621008731 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621008732 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 881621008733 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008734 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621008735 DNA binding residues [nucleotide binding] 881621008736 putative dimer interface [polypeptide binding]; other site 881621008737 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 881621008738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621008739 motif II; other site 881621008740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008742 DNA binding site [nucleotide binding] 881621008743 domain linker motif; other site 881621008744 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621008745 putative dimerization interface [polypeptide binding]; other site 881621008746 putative ligand binding site [chemical binding]; other site 881621008747 NAD-dependent deacetylase; Provisional; Region: PRK00481 881621008748 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 881621008749 NAD+ binding site [chemical binding]; other site 881621008750 substrate binding site [chemical binding]; other site 881621008751 putative Zn binding site [ion binding]; other site 881621008752 Pathogenicity locus; Region: Cdd1; pfam11731 881621008753 drug efflux system protein MdtG; Provisional; Region: PRK09874 881621008754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008755 putative substrate translocation pore; other site 881621008756 Src Homology 3 domain superfamily; Region: SH3; cl17036 881621008757 Variant SH3 domain; Region: SH3_2; pfam07653 881621008758 peptide ligand binding site [polypeptide binding]; other site 881621008759 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 881621008760 active site 881621008761 intersubunit interactions; other site 881621008762 catalytic residue [active] 881621008763 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621008764 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 881621008765 ligand binding site [chemical binding]; other site 881621008766 flexible hinge region; other site 881621008767 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 881621008768 putative switch regulator; other site 881621008769 non-specific DNA interactions [nucleotide binding]; other site 881621008770 DNA binding site [nucleotide binding] 881621008771 sequence specific DNA binding site [nucleotide binding]; other site 881621008772 putative cAMP binding site [chemical binding]; other site 881621008773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621008775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621008776 Walker A/P-loop; other site 881621008777 ATP binding site [chemical binding]; other site 881621008778 Q-loop/lid; other site 881621008779 ABC transporter signature motif; other site 881621008780 Walker B; other site 881621008781 D-loop; other site 881621008782 H-loop/switch region; other site 881621008783 TfoX C-terminal domain; Region: TfoX_C; pfam04994 881621008784 seryl-tRNA synthetase; Provisional; Region: PRK05431 881621008785 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 881621008786 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 881621008787 dimer interface [polypeptide binding]; other site 881621008788 active site 881621008789 motif 1; other site 881621008790 motif 2; other site 881621008791 motif 3; other site 881621008792 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 881621008793 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 881621008794 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 881621008795 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621008796 glutamine binding [chemical binding]; other site 881621008797 catalytic triad [active] 881621008798 aminodeoxychorismate synthase; Provisional; Region: PRK07508 881621008799 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621008800 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 881621008801 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 881621008802 substrate-cofactor binding pocket; other site 881621008803 homodimer interface [polypeptide binding]; other site 881621008804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008805 catalytic residue [active] 881621008806 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008807 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621008808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621008809 Walker A/P-loop; other site 881621008810 ATP binding site [chemical binding]; other site 881621008811 Q-loop/lid; other site 881621008812 ABC transporter signature motif; other site 881621008813 Walker B; other site 881621008814 D-loop; other site 881621008815 H-loop/switch region; other site 881621008816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 881621008818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 881621008819 Walker A/P-loop; other site 881621008820 ATP binding site [chemical binding]; other site 881621008821 Q-loop/lid; other site 881621008822 ABC transporter signature motif; other site 881621008823 Walker B; other site 881621008824 D-loop; other site 881621008825 H-loop/switch region; other site 881621008826 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 881621008827 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 881621008828 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 881621008829 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621008830 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 881621008831 DNA topoisomerase III; Provisional; Region: PRK07726 881621008832 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 881621008833 active site 881621008834 putative interdomain interaction site [polypeptide binding]; other site 881621008835 putative metal-binding site [ion binding]; other site 881621008836 putative nucleotide binding site [chemical binding]; other site 881621008837 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 881621008838 domain I; other site 881621008839 DNA binding groove [nucleotide binding] 881621008840 phosphate binding site [ion binding]; other site 881621008841 domain II; other site 881621008842 domain III; other site 881621008843 nucleotide binding site [chemical binding]; other site 881621008844 catalytic site [active] 881621008845 domain IV; other site 881621008846 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 881621008847 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 881621008848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621008849 ATP binding site [chemical binding]; other site 881621008850 putative Mg++ binding site [ion binding]; other site 881621008851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621008852 nucleotide binding region [chemical binding]; other site 881621008853 ATP-binding site [chemical binding]; other site 881621008854 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 881621008855 HRDC domain; Region: HRDC; pfam00570 881621008856 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 881621008857 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 881621008858 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 881621008859 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 881621008860 active site 881621008861 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 881621008862 putative ADP-ribose binding site [chemical binding]; other site 881621008863 putative active site [active] 881621008864 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008865 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008866 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 881621008867 beta-galactosidase; Region: BGL; TIGR03356 881621008868 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008869 active site 881621008870 P-loop; other site 881621008871 phosphorylation site [posttranslational modification] 881621008872 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 881621008873 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 881621008874 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621008875 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 881621008876 nucleotide binding site [chemical binding]; other site 881621008877 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008878 methionine cluster; other site 881621008879 active site 881621008880 phosphorylation site [posttranslational modification] 881621008881 metal binding site [ion binding]; metal-binding site 881621008882 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008883 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008884 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 881621008885 similar to beta-glucosidase, partial 881621008886 Similar to beta-glucoside-specific PTS system enzyme IIABC, C-terminal part 881621008887 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008888 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621008889 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 881621008890 putative active site [active] 881621008891 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 881621008892 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621008893 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 881621008894 Walker A/P-loop; other site 881621008895 ATP binding site [chemical binding]; other site 881621008896 Q-loop/lid; other site 881621008897 ABC transporter signature motif; other site 881621008898 Walker B; other site 881621008899 D-loop; other site 881621008900 H-loop/switch region; other site 881621008901 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 881621008902 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 881621008903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 881621008904 GTP-binding protein YchF; Reviewed; Region: PRK09601 881621008905 YchF GTPase; Region: YchF; cd01900 881621008906 G1 box; other site 881621008907 GTP/Mg2+ binding site [chemical binding]; other site 881621008908 Switch I region; other site 881621008909 G2 box; other site 881621008910 Switch II region; other site 881621008911 G3 box; other site 881621008912 G4 box; other site 881621008913 G5 box; other site 881621008914 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 881621008915 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 881621008916 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 881621008917 tetramer interface [polypeptide binding]; other site 881621008918 heme binding pocket [chemical binding]; other site 881621008919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 881621008920 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 881621008921 ParB-like nuclease domain; Region: ParB; smart00470 881621008922 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 881621008923 salt bridge; other site 881621008924 non-specific DNA binding site [nucleotide binding]; other site 881621008925 sequence-specific DNA binding site [nucleotide binding]; other site 881621008926 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 881621008927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 881621008928 P-loop; other site 881621008929 Magnesium ion binding site [ion binding]; other site 881621008930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 881621008931 Magnesium ion binding site [ion binding]; other site 881621008932 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 881621008933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621008934 non-specific DNA binding site [nucleotide binding]; other site 881621008935 salt bridge; other site 881621008936 sequence-specific DNA binding site [nucleotide binding]; other site 881621008937 purine nucleoside phosphorylase; Provisional; Region: PRK08202 881621008938 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 881621008939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 881621008940 active site 881621008941 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 881621008942 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 881621008943 substrate binding site [chemical binding]; other site 881621008944 dimer interface [polypeptide binding]; other site 881621008945 ATP binding site [chemical binding]; other site 881621008946 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008947 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008948 Walker A/P-loop; other site 881621008949 ATP binding site [chemical binding]; other site 881621008950 Q-loop/lid; other site 881621008951 ABC transporter signature motif; other site 881621008952 Walker B; other site 881621008953 D-loop; other site 881621008954 H-loop/switch region; other site 881621008955 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008956 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008957 Walker A/P-loop; other site 881621008958 ATP binding site [chemical binding]; other site 881621008959 Q-loop/lid; other site 881621008960 ABC transporter signature motif; other site 881621008961 Walker B; other site 881621008962 D-loop; other site 881621008963 H-loop/switch region; other site 881621008964 Cobalt transport protein; Region: CbiQ; cl00463 881621008965 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 881621008966 active site 881621008967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008968 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008969 DNA binding site [nucleotide binding] 881621008970 domain linker motif; other site 881621008971 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621008972 dimerization interface [polypeptide binding]; other site 881621008973 ligand binding site [chemical binding]; other site 881621008974 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 881621008975 ParB-like nuclease domain; Region: ParBc; pfam02195 881621008976 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 881621008977 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621008978 putative active site cavity [active] 881621008979 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 881621008980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 881621008981 S-adenosylmethionine binding site [chemical binding]; other site 881621008982 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 881621008983 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 881621008984 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 881621008985 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 881621008986 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 881621008987 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 881621008988 trmE is a tRNA modification GTPase; Region: trmE; cd04164 881621008989 G1 box; other site 881621008990 GTP/Mg2+ binding site [chemical binding]; other site 881621008991 Switch I region; other site 881621008992 G2 box; other site 881621008993 Switch II region; other site 881621008994 G3 box; other site 881621008995 G4 box; other site 881621008996 G5 box; other site 881621008997 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 881621008998 Cna protein B-type domain; Region: Cna_B; pfam05738 881621008999 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621009000 Uncharacterized conserved protein [Function unknown]; Region: COG4198 881621009001 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 881621009002 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 881621009003 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 881621009004 putative ligand binding site [chemical binding]; other site 881621009005 putative NAD binding site [chemical binding]; other site 881621009006 putative catalytic site [active] 881621009007 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 881621009008 L-serine binding site [chemical binding]; other site 881621009009 ACT domain interface; other site 881621009010 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 881621009011 homodimer interface [polypeptide binding]; other site 881621009012 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621009013 substrate-cofactor binding pocket; other site 881621009014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621009015 catalytic residue [active] 881621009016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621009017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621009018 putative substrate translocation pore; other site 881621009019 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621009020 MarR family; Region: MarR_2; pfam12802 881621009021 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 881621009022 dimer interface [polypeptide binding]; other site 881621009023 FMN binding site [chemical binding]; other site 881621009024 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621009025 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 881621009026 catalytic residues [active] 881621009027 beta-phosphoglucomutase; Region: bPGM; TIGR01990 881621009028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 881621009029 motif II; other site 881621009030 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 881621009031 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 881621009032 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621009033 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 881621009034 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621009035 similar to oxidoreductases, C-terminal part 881621009036 similar to oxidoreductases, N-terminal part 881621009037 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621009038 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621009039 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 881621009040 putative NAD(P) binding site [chemical binding]; other site 881621009041 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621009042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621009043 dimer interface [polypeptide binding]; other site 881621009044 conserved gate region; other site 881621009045 putative PBP binding loops; other site 881621009046 ABC-ATPase subunit interface; other site 881621009047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 881621009048 dimer interface [polypeptide binding]; other site 881621009049 conserved gate region; other site 881621009050 putative PBP binding loops; other site 881621009051 ABC-ATPase subunit interface; other site 881621009052 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621009053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 881621009054 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 881621009055 sucrose phosphorylase; Provisional; Region: PRK13840 881621009056 active site 881621009057 homodimer interface [polypeptide binding]; other site 881621009058 catalytic site [active] 881621009059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621009060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621009061 DNA binding site [nucleotide binding] 881621009062 domain linker motif; other site 881621009063 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 881621009064 putative dimerization interface [polypeptide binding]; other site 881621009065 putative ligand binding site [chemical binding]; other site 881621009066 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 881621009067 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 881621009068 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621009069 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 881621009070 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 881621009071 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 881621009072 G-X-X-G motif; other site 881621009073 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 881621009074 RxxxH motif; other site 881621009075 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 881621009076 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 881621009077 ribonuclease P; Reviewed; Region: rnpA; PRK00499 881621009078 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399