-- dump date 20111121_012902 -- class Genbank::misc_feature -- table misc_feature_note -- id note 881621000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 881621000002 hypothetical protein; Validated; Region: PRK06672 881621000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621000004 Walker A motif; other site 881621000005 ATP binding site [chemical binding]; other site 881621000006 Walker B motif; other site 881621000007 arginine finger; other site 881621000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 881621000009 DnaA box-binding interface [nucleotide binding]; other site 881621000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 881621000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 881621000012 putative DNA binding surface [nucleotide binding]; other site 881621000013 dimer interface [polypeptide binding]; other site 881621000014 beta-clamp/clamp loader binding surface; other site 881621000015 beta-clamp/translesion DNA polymerase binding surface; other site 881621000016 similar to unknown protein, C-terminal part 881621000017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 881621000018 recombination protein F; Reviewed; Region: recF; PRK00064 881621000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 881621000020 Walker A/P-loop; other site 881621000021 ATP binding site [chemical binding]; other site 881621000022 Q-loop/lid; other site 881621000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621000024 ABC transporter signature motif; other site 881621000025 Walker B; other site 881621000026 D-loop; other site 881621000027 H-loop/switch region; other site 881621000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 881621000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000030 Mg2+ binding site [ion binding]; other site 881621000031 G-X-G motif; other site 881621000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 881621000033 anchoring element; other site 881621000034 dimer interface [polypeptide binding]; other site 881621000035 ATP binding site [chemical binding]; other site 881621000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621000037 active site 881621000038 putative metal-binding site [ion binding]; other site 881621000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621000040 DNA gyrase subunit A; Validated; Region: PRK05560 881621000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 881621000042 CAP-like domain; other site 881621000043 Active site [active] 881621000044 primary dimer interface [polypeptide binding]; other site 881621000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621000051 cardiolipin synthetase; Reviewed; Region: PRK12452 881621000052 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621000053 putative active site [active] 881621000054 catalytic site [active] 881621000055 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621000056 putative active site [active] 881621000057 catalytic site [active] 881621000058 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 881621000059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621000060 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 881621000061 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 881621000062 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000063 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 881621000064 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 881621000065 Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 881621000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 881621000067 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 881621000068 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 881621000069 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 881621000070 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 881621000071 D-pathway; other site 881621000072 Putative ubiquinol binding site [chemical binding]; other site 881621000073 Low-spin heme (heme b) binding site [chemical binding]; other site 881621000074 Putative water exit pathway; other site 881621000075 Binuclear center (heme o3/CuB) [ion binding]; other site 881621000076 K-pathway; other site 881621000077 Putative proton exit pathway; other site 881621000078 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 881621000079 Subunit I/III interface [polypeptide binding]; other site 881621000080 Subunit III/IV interface [polypeptide binding]; other site 881621000081 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 881621000082 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000083 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 881621000084 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621000085 Bacterial SH3 domain; Region: SH3_3; cl02551 881621000086 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 881621000087 putative active site [active] 881621000088 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 881621000089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621000090 active site turn [active] 881621000091 phosphorylation site [posttranslational modification] 881621000092 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000093 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 881621000094 HPr interaction site; other site 881621000095 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000096 active site 881621000097 phosphorylation site [posttranslational modification] 881621000098 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621000099 putative dimer interface [polypeptide binding]; other site 881621000100 catalytic triad [active] 881621000101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621000103 Walker A/P-loop; other site 881621000104 ATP binding site [chemical binding]; other site 881621000105 Q-loop/lid; other site 881621000106 ABC transporter signature motif; other site 881621000107 Walker B; other site 881621000108 D-loop; other site 881621000109 H-loop/switch region; other site 881621000110 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 881621000111 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 881621000112 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621000114 active site 881621000115 motif I; other site 881621000116 motif II; other site 881621000117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621000118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000120 DNA binding site [nucleotide binding] 881621000121 domain linker motif; other site 881621000122 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 881621000123 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000124 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621000125 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 881621000126 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 881621000127 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000128 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621000129 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621000130 dimer interface [polypeptide binding]; other site 881621000131 active site 881621000132 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621000133 dimer interface [polypeptide binding]; other site 881621000134 active site 881621000135 putrescine carbamoyltransferase; Provisional; Region: PRK02255 881621000136 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621000137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000138 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621000139 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 881621000140 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000141 carbamate kinase; Reviewed; Region: PRK12686 881621000142 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 881621000143 putative substrate binding site [chemical binding]; other site 881621000144 nucleotide binding site [chemical binding]; other site 881621000145 nucleotide binding site [chemical binding]; other site 881621000146 homodimer interface [polypeptide binding]; other site 881621000147 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 881621000148 agmatine deiminase; Region: agmatine_aguA; TIGR03380 881621000149 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621000150 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621000151 putative active site [active] 881621000152 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621000153 Amidinotransferase; Region: Amidinotransf; cl12043 881621000154 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 881621000155 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 881621000156 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621000157 dimer interface [polypeptide binding]; other site 881621000158 ssDNA binding site [nucleotide binding]; other site 881621000159 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000160 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 881621000161 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621000162 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621000163 Accessory gene regulator B; Region: AgrB; cl01873 881621000164 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621000165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621000166 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 881621000167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621000168 active site 881621000169 phosphorylation site [posttranslational modification] 881621000170 intermolecular recognition site; other site 881621000171 dimerization interface [polypeptide binding]; other site 881621000172 LytTr DNA-binding domain; Region: LytTR; cl04498 881621000173 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 881621000174 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 881621000175 DHH family; Region: DHH; pfam01368 881621000176 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 881621000177 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 881621000178 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 881621000179 replicative DNA helicase; Provisional; Region: PRK05748 881621000180 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 881621000181 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 881621000182 Walker A motif; other site 881621000183 ATP binding site [chemical binding]; other site 881621000184 Walker B motif; other site 881621000185 DNA binding loops [nucleotide binding] 881621000186 adenylosuccinate synthetase; Provisional; Region: PRK01117 881621000187 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 881621000188 GDP-binding site [chemical binding]; other site 881621000189 ACT binding site; other site 881621000190 IMP binding site; other site 881621000191 Proteins of 100 residues with WXG; Region: WXG100; cl02005 881621000192 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621000193 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 881621000194 Predicted membrane protein [Function unknown]; Region: COG1511 881621000195 Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266 881621000196 YukD; Region: YukD; cl11566 881621000197 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, N-terminal part 881621000198 similar to Bacillus subtilis YukA protein possibly involved in protein secretion, C-terminal part 881621000199 Virulence factor EsxB; Region: EsxB; pfam10663 881621000200 Uncharacterized conserved protein [Function unknown]; Region: COG5444 881621000201 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 881621000202 tetramer interface [polypeptide binding]; other site 881621000203 active site 881621000204 Mg2+/Mn2+ binding site [ion binding]; other site 881621000205 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621000206 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621000207 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 881621000208 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621000209 DNA binding site [nucleotide binding] 881621000210 active site 881621000211 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 881621000212 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 881621000213 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 881621000214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000215 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621000216 active site 881621000217 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000218 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621000219 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000220 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621000221 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621000222 LRR adjacent; Region: LRR_adjacent; pfam08191 881621000223 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 881621000224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621000225 DNA-binding site [nucleotide binding]; DNA binding site 881621000226 UTRA domain; Region: UTRA; cl01230 881621000227 YdjC-like protein; Region: YdjC; cl01344 881621000228 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000229 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 881621000230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621000231 active site turn [active] 881621000232 phosphorylation site [posttranslational modification] 881621000233 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621000234 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 881621000235 NAD(P) binding site [chemical binding]; other site 881621000236 LDH/MDH dimer interface [polypeptide binding]; other site 881621000237 substrate binding site [chemical binding]; other site 881621000238 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000239 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000240 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 881621000241 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 881621000242 intersubunit interface [polypeptide binding]; other site 881621000243 active site 881621000244 Zn2+ binding site [ion binding]; other site 881621000245 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 881621000246 N- and C-terminal domain interface [polypeptide binding]; other site 881621000247 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 881621000248 active site 881621000249 catalytic site [active] 881621000250 metal binding site [ion binding]; metal-binding site 881621000251 ATP binding site [chemical binding]; other site 881621000252 carbohydrate binding site [chemical binding]; other site 881621000253 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 881621000254 L-fucose isomerase; Provisional; Region: fucI; PRK10991 881621000255 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947 881621000256 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621000257 trimer interface [polypeptide binding]; other site 881621000258 substrate binding site [chemical binding]; other site 881621000259 Mn binding site [ion binding]; other site 881621000260 Ion channel; Region: Ion_trans_2; cl11596 881621000261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000262 non-specific DNA binding site [nucleotide binding]; other site 881621000263 salt bridge; other site 881621000264 sequence-specific DNA binding site [nucleotide binding]; other site 881621000265 C-terminal domain; Region: RGG_Cterm; TIGR01716 881621000266 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 881621000267 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621000268 active pocket/dimerization site; other site 881621000269 active site 881621000270 phosphorylation site [posttranslational modification] 881621000271 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 881621000272 active site 881621000273 phosphorylation site [posttranslational modification] 881621000274 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621000275 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621000276 Domain of unknown function (DUF956); Region: DUF956; cl01917 881621000277 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 881621000278 Cupin domain; Region: Cupin_2; cl09118 881621000279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000281 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621000282 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 881621000283 active site turn [active] 881621000284 phosphorylation site [posttranslational modification] 881621000285 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000286 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000287 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 881621000288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000289 dimerization interface [polypeptide binding]; other site 881621000290 putative DNA binding site [nucleotide binding]; other site 881621000291 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621000292 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 881621000293 dimer interface [polypeptide binding]; other site 881621000294 FMN binding site [chemical binding]; other site 881621000295 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 881621000296 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 881621000297 active site 881621000298 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 881621000299 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 881621000300 chitin/cellulose binding site [chemical binding]; other site 881621000301 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000302 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621000303 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621000304 Walker A/P-loop; other site 881621000305 ATP binding site [chemical binding]; other site 881621000306 Q-loop/lid; other site 881621000307 ABC transporter signature motif; other site 881621000308 Walker B; other site 881621000309 D-loop; other site 881621000310 H-loop/switch region; other site 881621000311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621000312 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621000313 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621000314 Walker A/P-loop; other site 881621000315 ATP binding site [chemical binding]; other site 881621000316 Q-loop/lid; other site 881621000317 ABC transporter signature motif; other site 881621000318 Walker B; other site 881621000319 D-loop; other site 881621000320 H-loop/switch region; other site 881621000321 Cupin domain; Region: Cupin_2; cl09118 881621000322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000323 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621000324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621000325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621000326 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621000327 substrate binding pocket [chemical binding]; other site 881621000328 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000329 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000331 ligand binding site [chemical binding]; other site 881621000332 flexible hinge region; other site 881621000333 Domain of unknown function (DUF955); Region: DUF955; cl01076 881621000334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000335 non-specific DNA binding site [nucleotide binding]; other site 881621000336 salt bridge; other site 881621000337 sequence-specific DNA binding site [nucleotide binding]; other site 881621000338 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 881621000339 Holin family; Region: Phage_holin_4; cl01989 881621000340 Similar to autolysin: N-acetylmuramoyl-L-alanine amidase 881621000341 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621000342 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 881621000343 putative active site [active] 881621000344 putative metal binding site [ion binding]; other site 881621000345 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621000346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621000347 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 881621000348 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621000349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602 881621000350 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 881621000351 active site 881621000352 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 881621000353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000354 Coenzyme A binding pocket [chemical binding]; other site 881621000355 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 881621000356 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 881621000357 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621000358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000359 dimer interface [polypeptide binding]; other site 881621000360 conserved gate region; other site 881621000361 putative PBP binding loops; other site 881621000362 ABC-ATPase subunit interface; other site 881621000363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000364 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 881621000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000366 dimer interface [polypeptide binding]; other site 881621000367 conserved gate region; other site 881621000368 putative PBP binding loops; other site 881621000369 ABC-ATPase subunit interface; other site 881621000370 similar to unknown protein, partial 881621000371 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000372 peptide binding site [polypeptide binding]; other site 881621000373 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 881621000374 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621000375 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621000376 metal binding site [ion binding]; metal-binding site 881621000377 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 881621000378 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 881621000379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621000380 ABC-ATPase subunit interface; other site 881621000381 dimer interface [polypeptide binding]; other site 881621000382 putative PBP binding regions; other site 881621000383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621000385 ligand binding site [chemical binding]; other site 881621000386 flexible hinge region; other site 881621000387 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621000388 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 881621000389 DEAD_2; Region: DEAD_2; cl14887 881621000390 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621000391 sugar phosphate phosphatase; Provisional; Region: PRK10513 881621000392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621000393 active site 881621000394 motif I; other site 881621000395 motif II; other site 881621000396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621000397 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 881621000398 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 881621000399 active site 881621000400 NlpC/P60 family; Region: NLPC_P60; cl11438 881621000401 Beta-lactamase; Region: Beta-lactamase; cl01009 881621000402 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621000403 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621000404 peptide binding site [polypeptide binding]; other site 881621000405 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 881621000406 SxDxEG motif; other site 881621000407 active site 881621000408 metal binding site [ion binding]; metal-binding site 881621000409 homopentamer interface [polypeptide binding]; other site 881621000410 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 881621000411 putative transposase OrfB; Reviewed; Region: PHA02517 881621000412 Integrase core domain; Region: rve; cl01316 881621000413 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621000414 Collagen binding domain; Region: Collagen_bind; pfam05737 881621000415 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621000416 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621000417 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621000418 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621000419 DNA polymerase III subunit delta'; Validated; Region: PRK08058 881621000420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621000421 PSP1 C-terminal conserved region; Region: PSP1; cl00770 881621000422 Protein of unknown function (DUF972); Region: DUF972; cl01853 881621000423 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 881621000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621000425 S-adenosylmethionine binding site [chemical binding]; other site 881621000426 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 881621000427 GIY-YIG motif/motif A; other site 881621000428 putative active site [active] 881621000429 putative metal binding site [ion binding]; other site 881621000430 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621000431 Predicted methyltransferases [General function prediction only]; Region: COG0313 881621000432 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 881621000433 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 881621000434 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000435 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 881621000436 Uncharacterized conserved protein [Function unknown]; Region: COG5361 881621000437 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 881621000438 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 881621000439 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 881621000440 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 881621000441 active site 881621000442 HIGH motif; other site 881621000443 KMSKS motif; other site 881621000444 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 881621000445 tRNA binding surface [nucleotide binding]; other site 881621000446 anticodon binding site; other site 881621000447 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 881621000448 dimer interface [polypeptide binding]; other site 881621000449 putative tRNA-binding site [nucleotide binding]; other site 881621000450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621000451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621000452 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621000453 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000455 dimer interface [polypeptide binding]; other site 881621000456 conserved gate region; other site 881621000457 putative PBP binding loops; other site 881621000458 ABC-ATPase subunit interface; other site 881621000459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621000460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000461 dimer interface [polypeptide binding]; other site 881621000462 conserved gate region; other site 881621000463 putative PBP binding loops; other site 881621000464 ABC-ATPase subunit interface; other site 881621000465 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621000466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621000467 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621000468 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 881621000469 active site 881621000470 catalytic site [active] 881621000471 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621000472 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 881621000473 trimer interface [polypeptide binding]; other site 881621000474 active site 881621000475 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 881621000476 catalytic site [active] 881621000477 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000478 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621000479 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 881621000480 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 881621000481 active site 881621000482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 881621000483 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000484 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000485 Domain of unknown function (DUF348); Region: DUF348; pfam03990 881621000486 G5 domain; Region: G5; pfam07501 881621000487 3D domain; Region: 3D; cl01439 881621000488 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 881621000489 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 881621000490 putative active site [active] 881621000491 putative metal binding site [ion binding]; other site 881621000492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621000493 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 881621000494 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 881621000495 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621000496 YdjC-like protein; Region: YdjC; cl01344 881621000497 pur operon repressor; Provisional; Region: PRK09213 881621000498 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 881621000499 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621000500 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 881621000501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621000502 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621000503 Walker A/P-loop; other site 881621000504 ATP binding site [chemical binding]; other site 881621000505 Q-loop/lid; other site 881621000506 ABC transporter signature motif; other site 881621000507 Walker B; other site 881621000508 D-loop; other site 881621000509 H-loop/switch region; other site 881621000510 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621000511 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621000512 FtsX-like permease family; Region: FtsX; pfam02687 881621000513 SpoVG; Region: SpoVG; cl00915 881621000514 SpoVG; Region: SpoVG; cl00915 881621000515 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 881621000516 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 881621000517 Substrate binding site [chemical binding]; other site 881621000518 Mg++ binding site [ion binding]; other site 881621000519 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 881621000520 active site 881621000521 substrate binding site [chemical binding]; other site 881621000522 CoA binding site [chemical binding]; other site 881621000523 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 881621000524 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621000525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000526 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 881621000527 ActA Protein; Region: ActA; pfam05058 881621000528 ActA Protein; Region: ActA; pfam05058 881621000529 ActA Protein; Region: ActA; pfam05058 881621000530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621000531 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621000532 active site 881621000533 metal binding site [ion binding]; metal-binding site 881621000534 Domain of unknown function (DUF74); Region: DUF74; cl00426 881621000535 A new structural DNA glycosylase; Region: AlkD_like; cl11434 881621000536 Active site [active] 881621000537 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 881621000538 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621000539 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621000540 NAD binding site [chemical binding]; other site 881621000541 dimer interface [polypeptide binding]; other site 881621000542 substrate binding site [chemical binding]; other site 881621000543 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 881621000544 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 881621000545 5S rRNA interface [nucleotide binding]; other site 881621000546 CTC domain interface [polypeptide binding]; other site 881621000547 L16 interface [polypeptide binding]; other site 881621000548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000549 Coenzyme A binding pocket [chemical binding]; other site 881621000550 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 881621000551 putative active site [active] 881621000552 catalytic residue [active] 881621000553 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 881621000554 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 881621000555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621000556 ATP binding site [chemical binding]; other site 881621000557 putative Mg++ binding site [ion binding]; other site 881621000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621000559 nucleotide binding region [chemical binding]; other site 881621000560 ATP-binding site [chemical binding]; other site 881621000561 TRCF domain; Region: TRCF; cl04088 881621000562 stage V sporulation protein B; Region: spore_V_B; TIGR02900 881621000563 MatE; Region: MatE; cl10513 881621000564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621000565 RNA binding surface [nucleotide binding]; other site 881621000566 Septum formation initiator; Region: DivIC; cl11433 881621000567 hypothetical protein; Provisional; Region: PRK08582 881621000568 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621000569 RNA binding site [nucleotide binding]; other site 881621000570 FtsH Extracellular; Region: FtsH_ext; pfam06480 881621000571 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 881621000572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621000573 Walker A motif; other site 881621000574 ATP binding site [chemical binding]; other site 881621000575 Walker B motif; other site 881621000576 arginine finger; other site 881621000577 Peptidase family M41; Region: Peptidase_M41; pfam01434 881621000578 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 881621000579 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 881621000580 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 881621000581 dimerization interface [polypeptide binding]; other site 881621000582 domain crossover interface; other site 881621000583 redox-dependent activation switch; other site 881621000584 cysteine synthases; Region: cysKM; TIGR01136 881621000585 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 881621000586 dimer interface [polypeptide binding]; other site 881621000587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000588 catalytic residue [active] 881621000589 dihydropteroate synthase; Region: DHPS; TIGR01496 881621000590 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 881621000591 substrate binding pocket [chemical binding]; other site 881621000592 dimer interface [polypeptide binding]; other site 881621000593 inhibitor binding site; inhibition site 881621000594 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 881621000595 homooctamer interface [polypeptide binding]; other site 881621000596 active site 881621000597 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 881621000598 catalytic center binding site [active] 881621000599 ATP binding site [chemical binding]; other site 881621000600 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 881621000601 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 881621000602 FMN binding site [chemical binding]; other site 881621000603 active site 881621000604 catalytic residues [active] 881621000605 substrate binding site [chemical binding]; other site 881621000606 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 881621000607 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 881621000608 dimer interface [polypeptide binding]; other site 881621000609 putative anticodon binding site; other site 881621000610 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 881621000611 motif 1; other site 881621000612 active site 881621000613 motif 2; other site 881621000614 motif 3; other site 881621000615 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 881621000616 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 881621000617 UvrB/uvrC motif; Region: UVR; pfam02151 881621000618 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 881621000619 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 881621000620 ADP binding site [chemical binding]; other site 881621000621 phosphagen binding site; other site 881621000622 substrate specificity loop; other site 881621000623 Clp protease ATP binding subunit; Region: clpC; CHL00095 881621000624 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000625 Clp amino terminal domain; Region: Clp_N; pfam02861 881621000626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621000627 Walker A motif; other site 881621000628 ATP binding site [chemical binding]; other site 881621000629 Walker B motif; other site 881621000630 arginine finger; other site 881621000631 UvrB/uvrC motif; Region: UVR; pfam02151 881621000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621000633 Walker A motif; other site 881621000634 ATP binding site [chemical binding]; other site 881621000635 Walker B motif; other site 881621000636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621000637 DNA repair protein RadA; Provisional; Region: PRK11823 881621000638 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 881621000639 Walker A motif/ATP binding site; other site 881621000640 ATP binding site [chemical binding]; other site 881621000641 Walker B motif; other site 881621000642 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 881621000643 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 881621000644 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 881621000645 putative active site [active] 881621000646 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621000647 substrate binding site [chemical binding]; other site 881621000648 dimer interface [polypeptide binding]; other site 881621000649 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 881621000650 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000651 HIGH motif; other site 881621000652 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 881621000653 active site 881621000654 KMSKS motif; other site 881621000655 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621000656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621000657 putative DNA binding site [nucleotide binding]; other site 881621000658 putative Zn2+ binding site [ion binding]; other site 881621000659 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621000660 similar to pyruvate-formate lyase activating enzyme, partial 881621000661 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 881621000662 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621000663 putative active site cavity [active] 881621000664 similar to putative pyruvate formate-lyase 2,N-terminal part 881621000665 similar to putative pyruvate formate-lyase 2,C-terminal part 881621000666 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 881621000667 active site 881621000668 phosphorylation site [posttranslational modification] 881621000669 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621000670 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621000671 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621000672 active pocket/dimerization site; other site 881621000673 active site 881621000674 phosphorylation site [posttranslational modification] 881621000675 serine O-acetyltransferase; Region: cysE; TIGR01172 881621000676 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 881621000677 trimer interface [polypeptide binding]; other site 881621000678 active site 881621000679 substrate binding site [chemical binding]; other site 881621000680 CoA binding site [chemical binding]; other site 881621000681 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 881621000682 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000683 active site 881621000684 HIGH motif; other site 881621000685 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 881621000686 KMSKS motif; other site 881621000687 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 881621000688 tRNA binding surface [nucleotide binding]; other site 881621000689 anticodon binding site; other site 881621000690 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 881621000691 active site 881621000692 metal binding site [ion binding]; metal-binding site 881621000693 dimerization interface [polypeptide binding]; other site 881621000694 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 881621000695 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 881621000696 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621000697 YacP-like NYN domain; Region: NYN_YacP; cl01491 881621000698 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 881621000699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621000700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621000701 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 881621000702 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 881621000703 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 881621000704 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 881621000705 putative homodimer interface [polypeptide binding]; other site 881621000706 KOW motif; Region: KOW; cl00354 881621000707 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 881621000708 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 881621000709 23S rRNA interface [nucleotide binding]; other site 881621000710 L7/L12 interface [polypeptide binding]; other site 881621000711 putative thiostrepton binding site; other site 881621000712 L25 interface [polypeptide binding]; other site 881621000713 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 881621000714 mRNA/rRNA interface [nucleotide binding]; other site 881621000715 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 881621000716 23S rRNA interface [nucleotide binding]; other site 881621000717 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 881621000718 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 881621000719 core dimer interface [polypeptide binding]; other site 881621000720 peripheral dimer interface [polypeptide binding]; other site 881621000721 L10 interface [polypeptide binding]; other site 881621000722 L11 interface [polypeptide binding]; other site 881621000723 putative EF-Tu interaction site [polypeptide binding]; other site 881621000724 putative EF-G interaction site [polypeptide binding]; other site 881621000725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621000726 S-adenosylmethionine binding site [chemical binding]; other site 881621000727 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 881621000728 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 881621000729 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621000730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621000731 DNA binding site [nucleotide binding] 881621000732 domain linker motif; other site 881621000733 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621000734 putative dimerization interface [polypeptide binding]; other site 881621000735 putative ligand binding site [chemical binding]; other site 881621000736 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621000737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621000738 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000740 dimer interface [polypeptide binding]; other site 881621000741 conserved gate region; other site 881621000742 putative PBP binding loops; other site 881621000743 ABC-ATPase subunit interface; other site 881621000744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000746 dimer interface [polypeptide binding]; other site 881621000747 conserved gate region; other site 881621000748 putative PBP binding loops; other site 881621000749 ABC-ATPase subunit interface; other site 881621000750 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621000751 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621000752 sucrose phosphorylase; Provisional; Region: PRK13840 881621000753 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621000754 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 881621000755 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000757 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 881621000758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 881621000759 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 881621000760 RPB10 interaction site [polypeptide binding]; other site 881621000761 RPB1 interaction site [polypeptide binding]; other site 881621000762 RPB11 interaction site [polypeptide binding]; other site 881621000763 RPB3 interaction site [polypeptide binding]; other site 881621000764 RPB12 interaction site [polypeptide binding]; other site 881621000765 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 881621000766 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 881621000767 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 881621000768 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 881621000769 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 881621000770 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000771 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 881621000772 G-loop; other site 881621000773 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 881621000774 DNA binding site [nucleotide binding] 881621000775 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 881621000776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621000777 active site 881621000778 motif I; other site 881621000779 motif II; other site 881621000780 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 881621000781 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000782 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 881621000783 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 881621000784 metal binding site [ion binding]; metal-binding site 881621000785 dimer interface [polypeptide binding]; other site 881621000786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621000787 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621000788 Zn binding site [ion binding]; other site 881621000789 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621000790 Zn binding site [ion binding]; other site 881621000791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621000792 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621000793 catalytic core [active] 881621000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 881621000795 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 881621000796 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 881621000797 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000798 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621000799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621000800 Coenzyme A binding pocket [chemical binding]; other site 881621000801 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621000802 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000803 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621000804 similar to unknown protein, C-terminal part 881621000805 similar to unknown protein, N-terminal part, start codon is missing 881621000806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000807 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621000808 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 881621000809 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 881621000810 Walker A/P-loop; other site 881621000811 ATP binding site [chemical binding]; other site 881621000812 Q-loop/lid; other site 881621000813 ABC transporter signature motif; other site 881621000814 Walker B; other site 881621000815 D-loop; other site 881621000816 H-loop/switch region; other site 881621000817 TOBE domain; Region: TOBE_2; cl01440 881621000818 ATP cone domain; Region: ATP-cone; pfam03477 881621000819 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 881621000820 Class III ribonucleotide reductase; Region: RNR_III; cd01675 881621000821 effector binding site; other site 881621000822 active site 881621000823 Zn binding site [ion binding]; other site 881621000824 glycine loop; other site 881621000825 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 881621000826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 881621000827 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000828 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621000829 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621000830 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 881621000831 putative active site [active] 881621000832 catalytic triad [active] 881621000833 putative dimer interface [polypeptide binding]; other site 881621000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621000835 dimer interface [polypeptide binding]; other site 881621000836 conserved gate region; other site 881621000837 ABC-ATPase subunit interface; other site 881621000838 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 881621000839 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 881621000840 Walker A/P-loop; other site 881621000841 ATP binding site [chemical binding]; other site 881621000842 Q-loop/lid; other site 881621000843 ABC transporter signature motif; other site 881621000844 Walker B; other site 881621000845 D-loop; other site 881621000846 H-loop/switch region; other site 881621000847 NIL domain; Region: NIL; cl09633 881621000848 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 881621000849 aspartate aminotransferase; Provisional; Region: PRK07681 881621000850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621000851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621000852 homodimer interface [polypeptide binding]; other site 881621000853 catalytic residue [active] 881621000854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621000856 active site 881621000857 phosphorylation site [posttranslational modification] 881621000858 intermolecular recognition site; other site 881621000859 dimerization interface [polypeptide binding]; other site 881621000860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621000861 DNA binding site [nucleotide binding] 881621000862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621000863 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621000864 dimerization interface [polypeptide binding]; other site 881621000865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 881621000866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621000867 dimer interface [polypeptide binding]; other site 881621000868 phosphorylation site [posttranslational modification] 881621000869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621000870 ATP binding site [chemical binding]; other site 881621000871 Mg2+ binding site [ion binding]; other site 881621000872 G-X-G motif; other site 881621000873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 881621000874 YycH protein; Region: YycH; pfam07435 881621000875 YycH protein; Region: YycI; cl02015 881621000876 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 881621000877 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 881621000878 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 881621000879 protein binding site [polypeptide binding]; other site 881621000880 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000881 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621000882 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621000883 CAT RNA binding domain; Region: CAT_RBD; cl03904 881621000884 PRD domain; Region: PRD; pfam00874 881621000885 PRD domain; Region: PRD; pfam00874 881621000886 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621000887 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621000888 active site turn [active] 881621000889 phosphorylation site [posttranslational modification] 881621000890 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000891 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 881621000892 HPr interaction site; other site 881621000893 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621000894 active site 881621000895 phosphorylation site [posttranslational modification] 881621000896 similar to transcriptional antiterminator (BglG family), C-terminal part 881621000897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621000898 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621000899 Walker A/P-loop; other site 881621000900 ATP binding site [chemical binding]; other site 881621000901 Q-loop/lid; other site 881621000902 ABC transporter signature motif; other site 881621000903 Walker B; other site 881621000904 D-loop; other site 881621000905 H-loop/switch region; other site 881621000906 similar to unknown proteins, C-terminal part 881621000907 MucBP domain; Region: MucBP; pfam06458 881621000908 MucBP domain; Region: MucBP; pfam06458 881621000909 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621000910 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 881621000911 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 881621000912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000913 putative oxidoreductase; Provisional; Region: PRK10206 881621000914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621000915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621000916 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621000917 active site 881621000918 phosphorylation site [posttranslational modification] 881621000919 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 881621000920 P-loop; other site 881621000921 active site 881621000922 phosphorylation site [posttranslational modification] 881621000923 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000924 hypothetical protein; Provisional; Region: PRK08185 881621000925 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 881621000926 intersubunit interface [polypeptide binding]; other site 881621000927 active site 881621000928 zinc binding site [ion binding]; other site 881621000929 Na+ binding site [ion binding]; other site 881621000930 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621000931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621000932 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621000933 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621000934 conserved cys residue [active] 881621000935 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621000936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621000937 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 881621000938 nudix motif; other site 881621000939 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 881621000940 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 881621000941 PhnA protein; Region: PhnA; pfam03831 881621000942 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621000943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621000944 DNA-binding site [nucleotide binding]; DNA binding site 881621000945 UTRA domain; Region: UTRA; cl01230 881621000946 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621000947 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621000948 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621000949 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621000950 active site 881621000951 P-loop; other site 881621000952 phosphorylation site [posttranslational modification] 881621000953 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621000954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621000955 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 881621000956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621000957 non-specific DNA binding site [nucleotide binding]; other site 881621000958 salt bridge; other site 881621000959 sequence-specific DNA binding site [nucleotide binding]; other site 881621000960 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 881621000961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621000962 tetrameric interface [polypeptide binding]; other site 881621000963 NAD binding site [chemical binding]; other site 881621000964 catalytic residues [active] 881621000965 KduI/IolB family; Region: KduI; cl01508 881621000966 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 881621000967 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 881621000968 substrate binding site [chemical binding]; other site 881621000969 ATP binding site [chemical binding]; other site 881621000970 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 881621000971 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621000972 PYR/PP interface [polypeptide binding]; other site 881621000973 dimer interface [polypeptide binding]; other site 881621000974 TPP binding site [chemical binding]; other site 881621000975 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621000976 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 881621000977 TPP-binding site; other site 881621000978 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621000979 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621000980 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 881621000981 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621000982 ligand binding site [chemical binding]; other site 881621000983 active site 881621000984 UGI interface [polypeptide binding]; other site 881621000985 catalytic site [active] 881621000986 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 881621000987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864 881621000988 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 881621000989 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 881621000990 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 881621000991 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 881621000992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621000993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 881621000994 DNA binding residues [nucleotide binding] 881621000995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621000996 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 881621000997 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 881621000998 DXD motif; other site 881621000999 similar to unknown protein, C-terminal part 881621001000 similar to unknown protein, N-terminal part 881621001001 Bacterial SH3 domain; Region: SH3_3; cl02551 881621001002 NlpC/P60 family; Region: NLPC_P60; cl11438 881621001003 possibly truncated gene (N-terminal part) 881621001004 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 881621001005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001006 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001007 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001008 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001010 DNA-binding site [nucleotide binding]; DNA binding site 881621001011 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 881621001012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621001013 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621001014 Walker A/P-loop; other site 881621001015 ATP binding site [chemical binding]; other site 881621001016 Q-loop/lid; other site 881621001017 ABC transporter signature motif; other site 881621001018 Walker B; other site 881621001019 D-loop; other site 881621001020 H-loop/switch region; other site 881621001021 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621001022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621001023 FtsX-like permease family; Region: FtsX; pfam02687 881621001024 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 881621001025 putative hydrophobic ligand binding site [chemical binding]; other site 881621001026 Phosphate transporter family; Region: PHO4; cl00396 881621001027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 881621001028 putative metal binding site [ion binding]; other site 881621001029 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 881621001030 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621001031 trimer interface [polypeptide binding]; other site 881621001032 phosphoenolpyruvate synthase; Validated; Region: PRK06241 881621001033 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621001034 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621001035 similar to unknown protein, C-terminal part 881621001036 similar to unknown protein, N-terminal part 881621001037 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 881621001038 ZIP Zinc transporter; Region: Zip; pfam02535 881621001039 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 881621001040 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 881621001041 amidase; Provisional; Region: PRK06707 881621001042 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 881621001043 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 881621001044 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 881621001045 classical (c) SDRs; Region: SDR_c; cd05233 881621001046 NAD(P) binding site [chemical binding]; other site 881621001047 active site 881621001048 QueT transporter; Region: QueT; cl01932 881621001049 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001050 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621001051 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001052 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001053 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001054 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001055 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621001056 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621001057 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001058 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001059 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001060 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001061 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001062 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001063 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621001064 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001065 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001066 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001067 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001068 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621001069 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621001070 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621001071 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621001072 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001073 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001074 LRR adjacent; Region: LRR_adjacent; pfam08191 881621001075 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621001076 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621001077 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621001078 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 881621001079 Condensation domain; Region: Condensation; cl09290 881621001080 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 881621001081 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 881621001082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621001083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 881621001084 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621001085 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 881621001086 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 881621001087 Protein of unknown function DUF58; Region: DUF58; pfam01882 881621001088 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 881621001089 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621001090 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 881621001091 Sodium:solute symporter family; Region: SSF; cl00456 881621001092 Uncharacterized conserved protein [Function unknown]; Region: COG3535 881621001093 Protein of unknown function (DUF917); Region: DUF917; pfam06032 881621001094 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 881621001095 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 881621001096 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 881621001097 similar to unknown protein, N-terminal part 881621001098 similar to unknown protein, central part 881621001099 similar to unknown protein, partial 881621001100 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 881621001101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621001102 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 881621001103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621001104 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 881621001105 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 881621001106 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 881621001107 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 881621001108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 881621001109 FeS/SAM binding site; other site 881621001110 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 881621001111 similar to unknown protein, C-terminal part 881621001112 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621001113 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 881621001114 putative active site [active] 881621001115 putative nucleic acid binding site [nucleotide binding]; other site 881621001116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621001117 non-specific DNA binding site [nucleotide binding]; other site 881621001118 salt bridge; other site 881621001119 sequence-specific DNA binding site [nucleotide binding]; other site 881621001120 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 881621001121 putative FMN binding site [chemical binding]; other site 881621001122 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 881621001123 oxidoreductase; Provisional; Region: PRK07985 881621001124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001125 NAD(P) binding site [chemical binding]; other site 881621001126 active site 881621001127 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 881621001128 similar to unknown protein, partial 881621001129 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 881621001130 nudix motif; other site 881621001131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001133 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621001134 putative dimerization interface [polypeptide binding]; other site 881621001135 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 881621001136 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 881621001137 active site 881621001138 FMN binding site [chemical binding]; other site 881621001139 substrate binding site [chemical binding]; other site 881621001140 putative catalytic residue [active] 881621001141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 881621001142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001144 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621001145 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621001146 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621001147 shikimate binding site; other site 881621001148 NAD(P) binding site [chemical binding]; other site 881621001149 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 881621001150 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 881621001151 active site 881621001152 catalytic residue [active] 881621001153 dimer interface [polypeptide binding]; other site 881621001154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621001155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621001157 dimerization interface [polypeptide binding]; other site 881621001158 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621001159 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 881621001160 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 881621001161 active site 881621001162 catalytic triad [active] 881621001163 oxyanion hole [active] 881621001164 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 881621001165 similar to sugar transferase, fragment 881621001166 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621001167 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001168 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621001169 substrate binding site [chemical binding]; other site 881621001170 hexamer interface [polypeptide binding]; other site 881621001171 metal binding site [ion binding]; metal-binding site 881621001172 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001173 catalytic residue [active] 881621001174 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001175 PRD domain; Region: PRD; pfam00874 881621001176 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001177 P-loop; other site 881621001178 active site 881621001179 phosphorylation site [posttranslational modification] 881621001180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001181 active site 881621001182 phosphorylation site [posttranslational modification] 881621001183 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 881621001184 putative active site [active] 881621001185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001186 active site 881621001187 phosphorylation site [posttranslational modification] 881621001188 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001189 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621001190 substrate binding site [chemical binding]; other site 881621001191 hexamer interface [polypeptide binding]; other site 881621001192 metal binding site [ion binding]; metal-binding site 881621001193 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621001194 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621001195 putative NAD(P) binding site [chemical binding]; other site 881621001196 catalytic Zn binding site [ion binding]; other site 881621001197 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621001198 P-loop; other site 881621001199 active site 881621001200 phosphorylation site [posttranslational modification] 881621001201 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621001202 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 881621001203 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621001204 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 881621001205 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 881621001206 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 881621001207 catalytic triad [active] 881621001208 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 881621001209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001210 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621001212 Ligand Binding Site [chemical binding]; other site 881621001213 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621001214 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001215 catalytic core [active] 881621001216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621001218 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621001219 Walker A/P-loop; other site 881621001220 ATP binding site [chemical binding]; other site 881621001221 Q-loop/lid; other site 881621001222 ABC transporter signature motif; other site 881621001223 Walker B; other site 881621001224 D-loop; other site 881621001225 H-loop/switch region; other site 881621001226 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 881621001227 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 881621001228 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 881621001229 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 881621001230 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 881621001231 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 881621001232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001233 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 881621001234 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621001235 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 881621001236 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 881621001237 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621001238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621001239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 881621001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621001241 dimer interface [polypeptide binding]; other site 881621001242 conserved gate region; other site 881621001243 putative PBP binding loops; other site 881621001244 ABC-ATPase subunit interface; other site 881621001245 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621001246 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 881621001247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001248 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001249 Uncharacterized conserved protein [Function unknown]; Region: COG3538 881621001250 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 881621001251 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621001252 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621001253 putative active site [active] 881621001254 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621001255 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 881621001256 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 881621001257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621001259 putative substrate translocation pore; other site 881621001260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001261 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001262 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001263 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001264 NAD binding site [chemical binding]; other site 881621001265 sugar binding site [chemical binding]; other site 881621001266 divalent metal binding site [ion binding]; other site 881621001267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001268 dimer interface [polypeptide binding]; other site 881621001269 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 881621001270 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621001271 putative active site [active] 881621001272 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 881621001273 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621001274 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621001275 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001276 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 881621001277 DNA binding residues [nucleotide binding] 881621001278 dimer interface [polypeptide binding]; other site 881621001279 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 881621001280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298 881621001281 cellulose synthase regulator protein; Provisional; Region: PRK11114 881621001282 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 881621001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621001284 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 881621001285 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 881621001286 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001287 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001288 DNA binding site [nucleotide binding] 881621001289 domain linker motif; other site 881621001290 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621001291 putative dimerization interface [polypeptide binding]; other site 881621001292 putative ligand binding site [chemical binding]; other site 881621001293 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621001294 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 881621001295 NAD binding site [chemical binding]; other site 881621001296 sugar binding site [chemical binding]; other site 881621001297 divalent metal binding site [ion binding]; other site 881621001298 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621001299 dimer interface [polypeptide binding]; other site 881621001300 allantoate amidohydrolase; Reviewed; Region: PRK09290 881621001301 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 881621001302 active site 881621001303 metal binding site [ion binding]; metal-binding site 881621001304 dimer interface [polypeptide binding]; other site 881621001305 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621001306 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 881621001307 metal binding site [ion binding]; metal-binding site 881621001308 putative dimer interface [polypeptide binding]; other site 881621001309 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001310 Beta-lactamase; Region: Beta-lactamase; cl01009 881621001311 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621001312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 881621001313 intersubunit interface [polypeptide binding]; other site 881621001314 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 881621001315 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 881621001316 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 881621001317 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 881621001318 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 881621001319 Glucitol operon activator protein (GutM); Region: GutM; cl01890 881621001320 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 881621001321 SAF domain; Region: SAF; cl00555 881621001322 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621001323 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621001324 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621001325 Leucine-rich repeats; other site 881621001326 Substrate binding site [chemical binding]; other site 881621001327 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001332 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001333 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001334 FOG: CBS domain [General function prediction only]; Region: COG0517 881621001335 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 881621001336 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 881621001337 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 881621001338 dimer interface [polypeptide binding]; other site 881621001339 active site 881621001340 metal binding site [ion binding]; metal-binding site 881621001341 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 881621001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621001343 putative substrate translocation pore; other site 881621001344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 881621001345 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621001346 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001347 catalytic core [active] 881621001348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001349 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621001350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001351 catalytic core [active] 881621001352 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621001353 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 881621001354 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 881621001355 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 881621001356 glutamate dehydrogenase; Provisional; Region: PRK09414 881621001357 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 881621001358 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 881621001359 NAD(P) binding site [chemical binding]; other site 881621001360 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621001361 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 881621001362 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 881621001363 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 881621001364 substrate binding site [chemical binding]; other site 881621001365 glutamase interaction surface [polypeptide binding]; other site 881621001366 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 881621001367 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 881621001368 catalytic residues [active] 881621001369 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 881621001370 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 881621001371 putative active site [active] 881621001372 oxyanion strand; other site 881621001373 catalytic triad [active] 881621001374 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 881621001375 4-fold oligomerization interface [polypeptide binding]; other site 881621001376 putative active site pocket [active] 881621001377 metal binding residues [ion binding]; metal-binding site 881621001378 3-fold/trimer interface [polypeptide binding]; other site 881621001379 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 881621001380 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 881621001381 NAD binding site [chemical binding]; other site 881621001382 dimerization interface [polypeptide binding]; other site 881621001383 product binding site; other site 881621001384 substrate binding site [chemical binding]; other site 881621001385 zinc binding site [ion binding]; other site 881621001386 catalytic residues [active] 881621001387 ATP phosphoribosyltransferase; Region: HisG; cl15266 881621001388 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 881621001389 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 881621001390 dimer interface [polypeptide binding]; other site 881621001391 motif 1; other site 881621001392 active site 881621001393 motif 2; other site 881621001394 histidinol-phosphatase; Reviewed; Region: PRK08123 881621001395 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621001396 DNA binding site [nucleotide binding] 881621001397 active site 881621001398 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 881621001399 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621001400 Permease family; Region: Xan_ur_permease; pfam00860 881621001401 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621001402 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621001403 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621001404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001405 DNA-binding site [nucleotide binding]; DNA binding site 881621001406 UTRA domain; Region: UTRA; cl01230 881621001407 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001408 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001409 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 881621001410 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 881621001411 N- and C-terminal domain interface [polypeptide binding]; other site 881621001412 D-xylulose kinase; Region: XylB; TIGR01312 881621001413 active site 881621001414 catalytic site [active] 881621001415 metal binding site [ion binding]; metal-binding site 881621001416 xylulose binding site [chemical binding]; other site 881621001417 putative ATP binding site [chemical binding]; other site 881621001418 homodimer interface [polypeptide binding]; other site 881621001419 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 881621001420 Uncharacterized conserved protein [Function unknown]; Region: COG2966 881621001421 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 881621001422 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 881621001423 Predicted esterase [General function prediction only]; Region: COG0400 881621001424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001425 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 881621001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621001427 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001428 putative peptidoglycan binding site; other site 881621001429 Bacterial SH3 domain; Region: SH3_3; cl02551 881621001430 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001431 putative peptidoglycan binding site; other site 881621001432 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621001433 putative peptidoglycan binding site; other site 881621001434 NlpC/P60 family; Region: NLPC_P60; cl11438 881621001435 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 881621001436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001437 ATP binding site [chemical binding]; other site 881621001438 putative Mg++ binding site [ion binding]; other site 881621001439 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 881621001440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621001441 nucleotide binding region [chemical binding]; other site 881621001442 ATP-binding site [chemical binding]; other site 881621001443 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621001444 Domain of unknown function DUF20; Region: UPF0118; cl00465 881621001445 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621001446 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621001447 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 881621001448 DNA photolyase; Region: DNA_photolyase; pfam00875 881621001449 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 881621001450 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 881621001451 DAK2 domain; Region: Dak2; cl03685 881621001452 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 881621001453 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 881621001454 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 881621001455 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 881621001456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001457 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 881621001458 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621001459 homodimer interface [polypeptide binding]; other site 881621001460 substrate-cofactor binding pocket; other site 881621001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621001462 catalytic residue [active] 881621001463 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 881621001464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621001465 ligand binding site [chemical binding]; other site 881621001466 flexible hinge region; other site 881621001467 BioY family; Region: BioY; cl00560 881621001468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001469 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 881621001470 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621001471 weakly similar to transcription regulator,C-terminal part 881621001472 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621001473 MatE; Region: MatE; cl10513 881621001474 MatE; Region: MatE; cl10513 881621001475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001476 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001477 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621001478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001479 Walker A/P-loop; other site 881621001480 ATP binding site [chemical binding]; other site 881621001481 Q-loop/lid; other site 881621001482 ABC transporter signature motif; other site 881621001483 Walker B; other site 881621001484 D-loop; other site 881621001485 H-loop/switch region; other site 881621001486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621001487 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621001488 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621001489 Walker A/P-loop; other site 881621001490 ATP binding site [chemical binding]; other site 881621001491 Q-loop/lid; other site 881621001492 ABC transporter signature motif; other site 881621001493 Walker B; other site 881621001494 D-loop; other site 881621001495 H-loop/switch region; other site 881621001496 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621001497 active site residue [active] 881621001498 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001499 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001500 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001501 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621001502 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621001503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001504 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 881621001505 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 881621001506 putative NAD(P) binding site [chemical binding]; other site 881621001507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621001508 similar to glycerophosphodiester phosphodiesterase,partial 881621001509 Catalytic domain of Protein Kinases; Region: PKc; cd00180 881621001510 active site 881621001511 ATP binding site [chemical binding]; other site 881621001512 substrate binding site [chemical binding]; other site 881621001513 activation loop (A-loop); other site 881621001514 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 881621001515 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 881621001516 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621001517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621001518 Coenzyme A binding pocket [chemical binding]; other site 881621001519 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621001520 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621001521 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621001522 DNA binding residues [nucleotide binding] 881621001523 putative dimer interface [polypeptide binding]; other site 881621001524 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 881621001525 active site 881621001526 catalytic triad [active] 881621001527 oxyanion hole [active] 881621001528 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 881621001529 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621001530 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621001531 active site turn [active] 881621001532 phosphorylation site [posttranslational modification] 881621001533 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 881621001534 HPr interaction site; other site 881621001535 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001536 active site 881621001537 phosphorylation site [posttranslational modification] 881621001538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621001539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621001540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621001541 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 881621001542 AP (apurinic/apyrimidinic) site pocket; other site 881621001543 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621001544 DNA interaction; other site 881621001545 Metal-binding active site; metal-binding site 881621001546 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001548 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621001549 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 881621001550 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001551 ATP synthase subunit C; Region: ATP-synt_C; cl00466 881621001552 weakly similar to ATP synthase delta chain,N-terminal part 881621001553 weakly similar to ATP synthase delta chain,C-terminal part 881621001554 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 881621001555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001556 Walker A motif; other site 881621001557 ATP binding site [chemical binding]; other site 881621001558 Walker B motif; other site 881621001559 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621001560 ATP synthase; Region: ATP-synt; cl00365 881621001561 Similar to ATP synthase beta chain 881621001562 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 881621001563 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001564 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001565 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001566 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001567 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001568 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001569 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001570 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621001571 PRD domain; Region: PRD; pfam00874 881621001572 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621001573 P-loop; other site 881621001574 active site 881621001575 phosphorylation site [posttranslational modification] 881621001576 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001577 active site 881621001578 phosphorylation site [posttranslational modification] 881621001579 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621001580 active site 881621001581 phosphorylation site [posttranslational modification] 881621001582 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621001583 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 881621001584 P-loop; other site 881621001585 active site 881621001586 phosphorylation site [posttranslational modification] 881621001587 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 881621001588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621001589 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 881621001590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621001591 motif II; other site 881621001592 Rrf2 family protein; Region: rrf2_super; TIGR00738 881621001593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621001595 S-adenosylmethionine binding site [chemical binding]; other site 881621001596 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621001597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621001598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621001599 active site 881621001600 catalytic tetrad [active] 881621001601 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 881621001602 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621001604 motif II; other site 881621001605 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621001606 catalytic residue [active] 881621001607 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621001608 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 881621001609 Sulfatase; Region: Sulfatase; cl10460 881621001610 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 881621001611 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621001612 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 881621001613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 881621001614 putative metal binding site [ion binding]; other site 881621001615 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621001616 active site 881621001617 metal binding site [ion binding]; metal-binding site 881621001618 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621001619 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 881621001620 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001622 DNA-binding site [nucleotide binding]; DNA binding site 881621001623 Predicted membrane protein [Function unknown]; Region: COG1511 881621001624 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621001625 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences...; Region: SPEC; cl02488 881621001626 linker region; other site 881621001627 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001628 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001630 DNA-binding site [nucleotide binding]; DNA binding site 881621001631 FCD domain; Region: FCD; cl11656 881621001632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621001633 Protein of unknown function (DUF975); Region: DUF975; cl10504 881621001634 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621001635 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 881621001636 active site 881621001637 metal binding site [ion binding]; metal-binding site 881621001638 Protein of unknown function (DUF420); Region: DUF420; cl00989 881621001639 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 881621001640 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 881621001641 dimer interface [polypeptide binding]; other site 881621001642 substrate binding site [chemical binding]; other site 881621001643 ATP binding site [chemical binding]; other site 881621001644 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621001645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621001646 active site 881621001647 motif I; other site 881621001648 motif II; other site 881621001649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621001650 maltose O-acetyltransferase; Provisional; Region: PRK10092 881621001651 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621001652 active site 881621001653 substrate binding site [chemical binding]; other site 881621001654 trimer interface [polypeptide binding]; other site 881621001655 CoA binding site [chemical binding]; other site 881621001656 Protein of unknown function (DUF423); Region: DUF423; cl01008 881621001657 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621001658 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 881621001659 Walker A/P-loop; other site 881621001660 ATP binding site [chemical binding]; other site 881621001661 Q-loop/lid; other site 881621001662 ABC transporter signature motif; other site 881621001663 Walker B; other site 881621001664 D-loop; other site 881621001665 H-loop/switch region; other site 881621001666 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001667 Protein of unknown function (DUF805); Region: DUF805; cl01224 881621001668 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 881621001669 FliP family; Region: FliP; cl00593 881621001670 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 881621001671 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 881621001672 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 881621001673 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 881621001674 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 881621001675 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 881621001676 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 881621001677 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 881621001678 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 881621001679 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 881621001680 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 881621001681 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 881621001682 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 881621001683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621001684 flagellar motor protein MotA; Validated; Region: PRK08124 881621001685 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 881621001686 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 881621001687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 881621001688 ligand binding site [chemical binding]; other site 881621001689 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 881621001690 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 881621001691 putative metal binding site [ion binding]; other site 881621001692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621001693 binding surface 881621001694 TPR motif; other site 881621001695 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 881621001696 Response regulator receiver domain; Region: Response_reg; pfam00072 881621001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621001698 active site 881621001699 phosphorylation site [posttranslational modification] 881621001700 intermolecular recognition site; other site 881621001701 dimerization interface [polypeptide binding]; other site 881621001702 flagellin; Provisional; Region: PRK12805 881621001703 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001704 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 881621001705 Response regulator receiver domain; Region: Response_reg; pfam00072 881621001706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621001707 active site 881621001708 phosphorylation site [posttranslational modification] 881621001709 intermolecular recognition site; other site 881621001710 dimerization interface [polypeptide binding]; other site 881621001711 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 881621001712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 881621001713 putative binding surface; other site 881621001714 active site 881621001715 P2 response regulator binding domain; Region: P2; pfam07194 881621001716 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 881621001717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621001718 ATP binding site [chemical binding]; other site 881621001719 Mg2+ binding site [ion binding]; other site 881621001720 G-X-G motif; other site 881621001721 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 881621001722 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001723 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 881621001724 Flagellar hook capping protein; Region: FlgD; cl04347 881621001725 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 881621001726 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 881621001727 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 881621001728 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 881621001729 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 881621001730 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001731 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 881621001732 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001733 flagellar motor switch protein; Reviewed; Region: PRK06782 881621001734 CheC-like family; Region: CheC; pfam04509 881621001735 CheC-like family; Region: CheC; pfam04509 881621001736 CheC-like family; Region: CheC; pfam04509 881621001737 CheC-like family; Region: CheC; pfam04509 881621001738 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 881621001739 Protein of unknown function (DUF327); Region: DUF327; cl00753 881621001740 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 881621001741 glycoprotein BALF4; Provisional; Region: PHA03231 881621001742 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 881621001743 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 881621001744 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 881621001745 flagellar capping protein; Validated; Region: fliD; PRK06798 881621001746 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 881621001747 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 881621001748 Flagellar protein FliS; Region: FliS; cl00654 881621001749 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 881621001750 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 881621001751 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 881621001752 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 881621001753 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 881621001754 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 881621001755 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 881621001756 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 881621001757 FliG C-terminal domain; Region: FliG_C; pfam01706 881621001758 flagellar assembly protein H; Validated; Region: fliH; PRK06800 881621001759 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 881621001760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001761 Walker A motif; other site 881621001762 ATP binding site [chemical binding]; other site 881621001763 Walker B motif; other site 881621001764 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 881621001765 N-acetyl-D-glucosamine binding site [chemical binding]; other site 881621001766 catalytic residue [active] 881621001767 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621001768 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621001769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621001770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001771 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 881621001772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001773 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 881621001774 Walker A/P-loop; other site 881621001775 ATP binding site [chemical binding]; other site 881621001776 Q-loop/lid; other site 881621001777 ABC transporter signature motif; other site 881621001778 Walker B; other site 881621001779 D-loop; other site 881621001780 H-loop/switch region; other site 881621001781 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621001782 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 881621001783 pyruvate oxidase; Provisional; Region: PRK08611 881621001784 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 881621001785 PYR/PP interface [polypeptide binding]; other site 881621001786 tetramer interface [polypeptide binding]; other site 881621001787 dimer interface [polypeptide binding]; other site 881621001788 TPP binding site [chemical binding]; other site 881621001789 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621001790 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 881621001791 TPP-binding site [chemical binding]; other site 881621001792 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 881621001793 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 881621001794 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621001795 dimerization interface [polypeptide binding]; other site 881621001796 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 881621001797 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 881621001798 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 881621001799 putative active site [active] 881621001800 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 881621001801 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 881621001802 glutaminase active site [active] 881621001803 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621001804 dimer interface [polypeptide binding]; other site 881621001805 active site 881621001806 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621001807 dimer interface [polypeptide binding]; other site 881621001808 active site 881621001809 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621001810 active site 881621001811 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 881621001812 GIY-YIG motif/motif A; other site 881621001813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621001814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621001815 DNA binding site [nucleotide binding] 881621001816 domain linker motif; other site 881621001817 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621001818 ligand binding site [chemical binding]; other site 881621001819 dimerization interface [polypeptide binding]; other site 881621001820 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621001821 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621001822 substrate binding site [chemical binding]; other site 881621001823 hexamer interface [polypeptide binding]; other site 881621001824 metal binding site [ion binding]; metal-binding site 881621001825 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621001826 Protein of unknown function (DUF556); Region: DUF556; cl00822 881621001827 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621001828 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621001829 active site turn [active] 881621001830 phosphorylation site [posttranslational modification] 881621001831 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621001832 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 881621001833 HPr interaction site; other site 881621001834 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621001835 active site 881621001836 phosphorylation site [posttranslational modification] 881621001837 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 881621001838 MucBP domain; Region: MucBP; pfam06458 881621001839 MucBP domain; Region: MucBP; pfam06458 881621001840 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621001841 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621001842 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621001843 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621001844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001845 DNA-binding site [nucleotide binding]; DNA binding site 881621001846 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621001847 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621001848 Walker A/P-loop; other site 881621001849 ATP binding site [chemical binding]; other site 881621001850 Q-loop/lid; other site 881621001851 ABC transporter signature motif; other site 881621001852 Walker B; other site 881621001853 D-loop; other site 881621001854 H-loop/switch region; other site 881621001855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621001856 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621001857 Walker A/P-loop; other site 881621001858 ATP binding site [chemical binding]; other site 881621001859 Q-loop/lid; other site 881621001860 ABC transporter signature motif; other site 881621001861 Walker B; other site 881621001862 D-loop; other site 881621001863 H-loop/switch region; other site 881621001864 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621001865 FtsX-like permease family; Region: FtsX; pfam02687 881621001866 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621001867 Active site [active] 881621001868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621001869 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621001870 ligand binding site [chemical binding]; other site 881621001871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001872 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621001873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001874 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621001875 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 881621001876 active site 881621001877 Similar to beta-glucoside-specific PTS system enzyme IIABC (N terminal part) 881621001878 Similar to beta-glucoside-specific PTS system enzyme IIABC, central part 881621001879 Similar to beta-glucoside-specific PTS system enzyme IIABC, c-terminal part 881621001880 similar to putative purine nucleoside phosphorylase, N-terminal part 881621001881 similar to putative purine nucleoside phosphorylase, central part 881621001882 similar to putative purine nucleoside phosphorylase, c-terminal part 881621001883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 881621001884 active site 881621001885 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 881621001886 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621001887 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621001888 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621001889 Zn binding site [ion binding]; other site 881621001890 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621001891 Zn binding site [ion binding]; other site 881621001892 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 881621001893 Zn binding site [ion binding]; other site 881621001894 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 881621001895 Zn binding site [ion binding]; other site 881621001896 Predicted esterase [General function prediction only]; Region: COG0400 881621001897 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621001898 Flavin Reductases; Region: FlaRed; cl00801 881621001899 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 881621001900 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 881621001901 G1 box; other site 881621001902 GTP/Mg2+ binding site [chemical binding]; other site 881621001903 Switch I region; other site 881621001904 G2 box; other site 881621001905 G3 box; other site 881621001906 Switch II region; other site 881621001907 G4 box; other site 881621001908 G5 box; other site 881621001909 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621001910 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621001911 putative active site [active] 881621001912 putative metal binding site [ion binding]; other site 881621001913 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621001914 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621001915 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621001916 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621001917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621001918 DNA-binding site [nucleotide binding]; DNA binding site 881621001919 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 881621001920 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 881621001921 NAD(P) binding site [chemical binding]; other site 881621001922 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 881621001923 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621001924 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621001925 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001926 VanZ like family; Region: VanZ; cl01971 881621001927 Protein of unknown function (DUF986); Region: DUF986; cl01983 881621001928 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621001929 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621001930 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001 881621001931 active site 881621001932 phosphorylation site [posttranslational modification] 881621001933 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621001934 active pocket/dimerization site; other site 881621001935 active site 881621001936 phosphorylation site [posttranslational modification] 881621001937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001938 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621001939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621001940 Walker A motif; other site 881621001941 ATP binding site [chemical binding]; other site 881621001942 Walker B motif; other site 881621001943 arginine finger; other site 881621001944 Transcriptional antiterminator [Transcription]; Region: COG3933 881621001945 PRD domain; Region: PRD; pfam00874 881621001946 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621001947 active pocket/dimerization site; other site 881621001948 active site 881621001949 phosphorylation site [posttranslational modification] 881621001950 PRD domain; Region: PRD; pfam00874 881621001951 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621001952 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621001953 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001954 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 881621001955 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621001956 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 881621001957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 881621001958 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 881621001959 putative deacylase active site [active] 881621001960 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621001961 Protein of unknown function (DUF554); Region: DUF554; cl00784 881621001962 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621001963 NAD binding site [chemical binding]; other site 881621001964 putative active site [active] 881621001965 substrate binding site [chemical binding]; other site 881621001966 Predicted permeases [General function prediction only]; Region: RarD; COG2962 881621001967 EamA-like transporter family; Region: EamA; cl01037 881621001968 YceI-like domain; Region: YceI; cl01001 881621001969 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621001970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621001971 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621001972 Amino acid permease; Region: AA_permease; pfam00324 881621001973 PAS domain S-box; Region: sensory_box; TIGR00229 881621001974 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621001975 putative active site [active] 881621001976 heme pocket [chemical binding]; other site 881621001977 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621001978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 881621001979 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621001980 synthetase active site [active] 881621001981 NTP binding site [chemical binding]; other site 881621001982 metal binding site [ion binding]; metal-binding site 881621001983 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621001984 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 881621001985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621001986 non-specific DNA binding site [nucleotide binding]; other site 881621001987 salt bridge; other site 881621001988 sequence-specific DNA binding site [nucleotide binding]; other site 881621001989 Cupin domain; Region: Cupin_2; cl09118 881621001990 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 881621001991 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 881621001992 Walker A/P-loop; other site 881621001993 ATP binding site [chemical binding]; other site 881621001994 Q-loop/lid; other site 881621001995 ABC transporter signature motif; other site 881621001996 Walker B; other site 881621001997 D-loop; other site 881621001998 H-loop/switch region; other site 881621001999 TOBE domain; Region: TOBE_2; cl01440 881621002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 881621002001 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 881621002002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002003 dimer interface [polypeptide binding]; other site 881621002004 conserved gate region; other site 881621002005 putative PBP binding loops; other site 881621002006 ABC-ATPase subunit interface; other site 881621002007 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 881621002008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002009 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002010 similar to transcription regulator (C-terminal part) 881621002011 Similar to transcription regulator (N-terminal part) 881621002012 similar to unknown protein, C-terminal part 881621002013 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 881621002014 active site 881621002015 zinc binding site [ion binding]; other site 881621002016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621002017 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621002018 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621002019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621002020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621002021 active site 881621002022 phosphorylation site [posttranslational modification] 881621002023 intermolecular recognition site; other site 881621002024 dimerization interface [polypeptide binding]; other site 881621002025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621002026 DNA binding site [nucleotide binding] 881621002027 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621002028 dimerization interface [polypeptide binding]; other site 881621002029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621002030 dimer interface [polypeptide binding]; other site 881621002031 phosphorylation site [posttranslational modification] 881621002032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002033 ATP binding site [chemical binding]; other site 881621002034 Mg2+ binding site [ion binding]; other site 881621002035 G-X-G motif; other site 881621002036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621002037 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621002038 Walker A/P-loop; other site 881621002039 ATP binding site [chemical binding]; other site 881621002040 Q-loop/lid; other site 881621002041 ABC transporter signature motif; other site 881621002042 Walker B; other site 881621002043 D-loop; other site 881621002044 H-loop/switch region; other site 881621002045 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 881621002046 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 881621002047 FMN binding site [chemical binding]; other site 881621002048 substrate binding site [chemical binding]; other site 881621002049 putative catalytic residue [active] 881621002050 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621002051 dimer interface [polypeptide binding]; other site 881621002052 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621002053 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002054 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621002056 motif II; other site 881621002057 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621002059 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621002060 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621002061 DNA binding residues [nucleotide binding] 881621002062 putative dimer interface [polypeptide binding]; other site 881621002063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621002064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621002065 active site 881621002066 catalytic tetrad [active] 881621002067 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002068 similar to internalin, putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002069 similar to Putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621002070 similar to Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621002071 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 881621002072 homodimer interface [polypeptide binding]; other site 881621002073 NAD binding site [chemical binding]; other site 881621002074 catalytic residues [active] 881621002075 substrate binding pocket [chemical binding]; other site 881621002076 flexible flap; other site 881621002077 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 881621002078 active site 881621002079 substrate binding site [chemical binding]; other site 881621002080 trimer interface [polypeptide binding]; other site 881621002081 CoA binding site [chemical binding]; other site 881621002082 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 881621002083 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002084 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 881621002085 PhoU domain; Region: PhoU; pfam01895 881621002086 PhoU domain; Region: PhoU; pfam01895 881621002087 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 881621002088 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 881621002089 dimer interface [polypeptide binding]; other site 881621002090 PYR/PP interface [polypeptide binding]; other site 881621002091 TPP binding site [chemical binding]; other site 881621002092 substrate binding site [chemical binding]; other site 881621002093 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 881621002094 Domain of unknown function; Region: EKR; cl11037 881621002095 4Fe-4S binding domain; Region: Fer4; cl02805 881621002096 TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377 881621002097 TPP-binding site [chemical binding]; other site 881621002098 dimer interface [polypeptide binding]; other site 881621002099 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 881621002100 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 881621002101 Membrane transport protein; Region: Mem_trans; cl09117 881621002102 Phosphate-starvation-inducible E; Region: PsiE; cl01264 881621002103 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621002104 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621002105 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 881621002106 Walker A/P-loop; other site 881621002107 ATP binding site [chemical binding]; other site 881621002108 Q-loop/lid; other site 881621002109 ABC transporter signature motif; other site 881621002110 Walker B; other site 881621002111 D-loop; other site 881621002112 H-loop/switch region; other site 881621002113 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 881621002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002115 putative substrate translocation pore; other site 881621002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002117 putative substrate translocation pore; other site 881621002118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002122 dimerization interface [polypeptide binding]; other site 881621002123 EamA-like transporter family; Region: EamA; cl01037 881621002124 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621002125 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 881621002126 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621002127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621002128 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621002129 similar to unknown protein (N-terminal part) 881621002130 similar to unknown protein (C-terminal part) 881621002131 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 881621002132 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 881621002133 homotrimer interaction site [polypeptide binding]; other site 881621002134 putative active site [active] 881621002135 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 881621002136 substrate binding site [chemical binding]; other site 881621002137 zinc-binding site [ion binding]; other site 881621002138 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621002139 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621002140 GIY-YIG motif/motif A; other site 881621002141 active site 881621002142 catalytic site [active] 881621002143 putative DNA binding site [nucleotide binding]; other site 881621002144 metal binding site [ion binding]; metal-binding site 881621002145 UvrB/uvrC motif; Region: UVR; pfam02151 881621002146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 881621002147 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621002148 substrate binding pocket [chemical binding]; other site 881621002149 membrane-bound complex binding site; other site 881621002150 hinge residues; other site 881621002151 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621002152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002153 dimer interface [polypeptide binding]; other site 881621002154 conserved gate region; other site 881621002155 putative PBP binding loops; other site 881621002156 ABC-ATPase subunit interface; other site 881621002157 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621002158 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 881621002159 Walker A/P-loop; other site 881621002160 ATP binding site [chemical binding]; other site 881621002161 Q-loop/lid; other site 881621002162 ABC transporter signature motif; other site 881621002163 Walker B; other site 881621002164 D-loop; other site 881621002165 H-loop/switch region; other site 881621002166 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621002167 MucBP domain; Region: MucBP; pfam06458 881621002168 MucBP domain; Region: MucBP; pfam06458 881621002169 partial 881621002170 similar to internalin, putative peptidoglycan linked protein (LPXTG motif) 881621002171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621002173 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 881621002174 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 881621002175 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 881621002176 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 881621002177 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621002178 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 881621002179 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621002180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621002181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621002182 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 881621002183 Esterase/lipase [General function prediction only]; Region: COG1647 881621002184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002186 DNA binding site [nucleotide binding] 881621002187 domain linker motif; other site 881621002188 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 881621002189 putative dimerization interface [polypeptide binding]; other site 881621002190 putative ligand binding site [chemical binding]; other site 881621002191 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621002192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002193 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 881621002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002195 dimer interface [polypeptide binding]; other site 881621002196 conserved gate region; other site 881621002197 putative PBP binding loops; other site 881621002198 ABC-ATPase subunit interface; other site 881621002199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002200 dimer interface [polypeptide binding]; other site 881621002201 conserved gate region; other site 881621002202 ABC-ATPase subunit interface; other site 881621002203 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621002204 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621002205 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 881621002206 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 881621002207 active site 881621002208 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 881621002209 active site 881621002210 substrate binding site [chemical binding]; other site 881621002211 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621002212 metal binding site [ion binding]; metal-binding site 881621002213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 881621002214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621002215 ATP binding site [chemical binding]; other site 881621002216 Mg++ binding site [ion binding]; other site 881621002217 motif III; other site 881621002218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621002219 nucleotide binding region [chemical binding]; other site 881621002220 Hef nuclease; Provisional; Region: PRK13766 881621002221 ATP-binding site [chemical binding]; other site 881621002222 Viral enhancin protein; Region: Enhancin; pfam03272 881621002223 Viral enhancin protein; Region: Enhancin; pfam03272 881621002224 Viral enhancin protein; Region: Enhancin; pfam03272 881621002225 Viral enhancin protein; Region: Enhancin; pfam03272 881621002226 Viral enhancin protein; Region: Enhancin; pfam03272 881621002227 Viral enhancin protein; Region: Enhancin; pfam03272 881621002228 QueT transporter; Region: QueT; cl01932 881621002229 similar to unknown protein (C-terminal part) 881621002230 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 881621002231 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621002232 PRD domain; Region: PRD; pfam00874 881621002233 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621002234 P-loop; other site 881621002235 active site 881621002236 phosphorylation site [posttranslational modification] 881621002237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002238 active site 881621002239 phosphorylation site [posttranslational modification] 881621002240 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002241 methionine cluster; other site 881621002242 active site 881621002243 phosphorylation site [posttranslational modification] 881621002244 metal binding site [ion binding]; metal-binding site 881621002245 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621002246 active site 881621002247 P-loop; other site 881621002248 phosphorylation site [posttranslational modification] 881621002249 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002250 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 881621002251 active site 881621002252 trimer interface [polypeptide binding]; other site 881621002253 allosteric site; other site 881621002254 active site lid [active] 881621002255 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002256 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621002257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621002258 active site 881621002259 catalytic tetrad [active] 881621002260 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621002261 Bacterial membrane flanked domain; Region: DUF304; cl01348 881621002262 Predicted membrane protein [Function unknown]; Region: COG3428 881621002263 Bacterial membrane flanked domain; Region: DUF304; cl01348 881621002264 Bacterial membrane flanked domain; Region: DUF304; cl01348 881621002265 Bacterial membrane flanked domain; Region: DUF304; cl01348 881621002266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002267 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 881621002268 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 881621002269 alanine racemase; Reviewed; Region: alr; PRK00053 881621002270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 881621002271 active site 881621002272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621002273 dimer interface [polypeptide binding]; other site 881621002274 substrate binding site [chemical binding]; other site 881621002275 catalytic residues [active] 881621002276 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 881621002277 PemK-like protein; Region: PemK; cl00995 881621002278 Rsbr N terminal; Region: Rsbr_N; pfam08678 881621002279 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002280 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621002281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621002282 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 881621002283 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 881621002284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 881621002285 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 881621002286 anti sigma factor interaction site; other site 881621002287 regulatory phosphorylation site [posttranslational modification]; other site 881621002288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002289 ATP binding site [chemical binding]; other site 881621002290 Mg2+ binding site [ion binding]; other site 881621002291 G-X-G motif; other site 881621002292 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 881621002293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621002294 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621002295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 881621002296 DNA binding residues [nucleotide binding] 881621002297 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 881621002298 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 881621002299 putative transporter; Provisional; Region: PRK11660 881621002300 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621002301 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 881621002302 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 881621002303 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 881621002304 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 881621002305 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 881621002306 RNA binding site [nucleotide binding]; other site 881621002307 hypothetical protein; Provisional; Region: PRK04351 881621002308 SprT homologues; Region: SprT; cl01182 881621002309 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621002310 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002311 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002313 DNA-binding site [nucleotide binding]; DNA binding site 881621002314 UTRA domain; Region: UTRA; cl01230 881621002315 OsmC-like protein; Region: OsmC; cl00767 881621002316 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621002317 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 881621002318 glutathione reductase; Validated; Region: PRK06116 881621002319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621002321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621002322 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621002323 catalytic core [active] 881621002324 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621002325 Domain of unknown function DUF20; Region: UPF0118; cl00465 881621002326 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621002327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002328 DNA-binding site [nucleotide binding]; DNA binding site 881621002329 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 881621002330 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 881621002331 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 881621002332 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 881621002333 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 881621002334 tetramerization interface [polypeptide binding]; other site 881621002335 NAD(P) binding site [chemical binding]; other site 881621002336 catalytic residues [active] 881621002337 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 881621002338 P-loop; other site 881621002339 active site 881621002340 phosphorylation site [posttranslational modification] 881621002341 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002342 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621002343 methionine cluster; other site 881621002344 active site 881621002345 phosphorylation site [posttranslational modification] 881621002346 metal binding site [ion binding]; metal-binding site 881621002347 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621002348 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 881621002349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002350 PRD domain; Region: PRD; pfam00874 881621002351 PRD domain; Region: PRD; pfam00874 881621002352 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621002353 active site 881621002354 phosphorylation site [posttranslational modification] 881621002355 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621002356 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621002357 ABC transporter; Region: ABC_tran_2; pfam12848 881621002358 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621002359 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621002360 Predicted permease; Region: DUF318; cl00487 881621002361 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 881621002362 pantothenate kinase; Provisional; Region: PRK05439 881621002363 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 881621002364 ATP-binding site [chemical binding]; other site 881621002365 CoA-binding site [chemical binding]; other site 881621002366 Mg2+-binding site [ion binding]; other site 881621002367 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 881621002368 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 881621002369 Walker A/P-loop; other site 881621002370 ATP binding site [chemical binding]; other site 881621002371 Q-loop/lid; other site 881621002372 ABC transporter signature motif; other site 881621002373 Walker B; other site 881621002374 D-loop; other site 881621002375 H-loop/switch region; other site 881621002376 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621002377 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621002380 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621002381 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 881621002382 Sulfatase; Region: Sulfatase; cl10460 881621002383 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 881621002384 active site 881621002385 DNA binding site [nucleotide binding] 881621002386 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 881621002387 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621002388 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 881621002389 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621002390 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 881621002391 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 881621002392 Ligand binding site [chemical binding]; other site 881621002393 Putative Catalytic site [active] 881621002394 DXD motif; other site 881621002395 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 881621002396 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 881621002397 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 881621002398 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 881621002399 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 881621002400 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621002401 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 881621002402 dimer interface [polypeptide binding]; other site 881621002403 FMN binding site [chemical binding]; other site 881621002404 NADPH bind site [chemical binding]; other site 881621002405 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621002406 Active site [active] 881621002407 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 881621002408 similar to heat shock protein HtpG, C-terminal part 881621002409 similar to heat shock protein HtpG, N-terminal part 881621002410 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 881621002411 Ferritin-like domain; Region: Ferritin; pfam00210 881621002412 dimerization interface [polypeptide binding]; other site 881621002413 DPS ferroxidase diiron center [ion binding]; other site 881621002414 ion pore; other site 881621002415 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 881621002416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621002417 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 881621002418 Protein of unknown function, DUF655; Region: DUF655; cl00648 881621002419 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 881621002420 hypothetical transport protein, C-terminal part 881621002421 hypothetical transport protein, N-terminal part 881621002422 Transcriptional regulators [Transcription]; Region: FadR; COG2186 881621002423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002424 DNA-binding site [nucleotide binding]; DNA binding site 881621002425 FCD domain; Region: FCD; cl11656 881621002426 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621002427 Domain of unknown function DUF20; Region: UPF0118; cl00465 881621002428 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 881621002429 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 881621002430 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 881621002431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002432 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 881621002433 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 881621002434 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621002435 MucBP domain; Region: MucBP; pfam06458 881621002436 MucBP domain; Region: MucBP; pfam06458 881621002437 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 881621002438 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 881621002439 active site 881621002440 dimer interface [polypeptide binding]; other site 881621002441 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 881621002442 active site 881621002443 trimer interface [polypeptide binding]; other site 881621002444 allosteric site; other site 881621002445 active site lid [active] 881621002446 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621002448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621002449 DNA-binding site [nucleotide binding]; DNA binding site 881621002450 UTRA domain; Region: UTRA; cl01230 881621002451 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621002452 Mg++ binding site [ion binding]; other site 881621002453 putative catalytic motif [active] 881621002454 substrate binding site [chemical binding]; other site 881621002455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 881621002456 Peptidase family U32; Region: Peptidase_U32; cl03113 881621002457 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 881621002458 Peptidase family U32; Region: Peptidase_U32; cl03113 881621002459 LemA family; Region: LemA; cl00742 881621002460 Peptidase family M48; Region: Peptidase_M48; cl12018 881621002461 similar to ABC transporter (ATP-binding protein),C-terminal part 881621002462 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 881621002463 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 881621002464 catalytic residues [active] 881621002465 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 881621002466 putative active site [active] 881621002467 putative metal binding residues [ion binding]; other site 881621002468 signature motif; other site 881621002469 putative triphosphate binding site [ion binding]; other site 881621002470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621002471 TPR motif; other site 881621002472 binding surface 881621002473 Tetratrico peptide repeat; Region: TPR_5; pfam12688 881621002474 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621002475 synthetase active site [active] 881621002476 NTP binding site [chemical binding]; other site 881621002477 metal binding site [ion binding]; metal-binding site 881621002478 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621002479 ATP-NAD kinase; Region: NAD_kinase; pfam01513 881621002480 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621002481 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 881621002482 active site 881621002483 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 881621002484 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 881621002485 NAD binding site [chemical binding]; other site 881621002486 homotetramer interface [polypeptide binding]; other site 881621002487 homodimer interface [polypeptide binding]; other site 881621002488 substrate binding site [chemical binding]; other site 881621002489 active site 881621002490 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 881621002491 DltD N-terminal region; Region: DltD_N; pfam04915 881621002492 DltD central region; Region: DltD_M; pfam04918 881621002493 DltD C-terminal region; Region: DltD_C; pfam04914 881621002494 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963 881621002495 MBOAT family; Region: MBOAT; cl00738 881621002496 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 881621002497 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 881621002498 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 881621002499 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621002500 active site 881621002501 dimer interface [polypeptide binding]; other site 881621002502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621002503 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621002504 Putative esterase; Region: Esterase; pfam00756 881621002505 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 881621002506 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 881621002507 homodimer interface [polypeptide binding]; other site 881621002508 substrate-cofactor binding pocket; other site 881621002509 catalytic residue [active] 881621002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621002512 putative substrate translocation pore; other site 881621002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621002514 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621002515 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 881621002516 putative oligomer interface [polypeptide binding]; other site 881621002517 putative active site [active] 881621002518 metal binding site [ion binding]; metal-binding site 881621002519 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 881621002520 catalytic residues [active] 881621002521 dimer interface [polypeptide binding]; other site 881621002522 LytTr DNA-binding domain; Region: LytTR; cl04498 881621002523 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621002524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621002525 Walker A/P-loop; other site 881621002526 ATP binding site [chemical binding]; other site 881621002527 Q-loop/lid; other site 881621002528 ABC transporter signature motif; other site 881621002529 Walker B; other site 881621002530 D-loop; other site 881621002531 H-loop/switch region; other site 881621002532 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002533 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 881621002534 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 881621002535 G1 box; other site 881621002536 putative GEF interaction site [polypeptide binding]; other site 881621002537 GTP/Mg2+ binding site [chemical binding]; other site 881621002538 Switch I region; other site 881621002539 G2 box; other site 881621002540 G3 box; other site 881621002541 Switch II region; other site 881621002542 G4 box; other site 881621002543 G5 box; other site 881621002544 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 881621002545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002546 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621002547 MatE; Region: MatE; cl10513 881621002548 Integral membrane protein TerC family; Region: TerC; cl10468 881621002549 Integral membrane protein TerC family; Region: TerC; cl10468 881621002550 Cation transport protein; Region: TrkH; cl10514 881621002551 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 881621002552 Cation transport protein; Region: TrkH; cl10514 881621002553 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 881621002554 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 881621002555 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621002556 DNA binding site [nucleotide binding] 881621002557 active site 881621002558 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 881621002559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621002560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 881621002561 Walker A motif; other site 881621002562 ATP binding site [chemical binding]; other site 881621002563 Walker B motif; other site 881621002564 arginine finger; other site 881621002565 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 881621002566 UvrB/uvrC motif; Region: UVR; pfam02151 881621002567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621002568 Walker A motif; other site 881621002569 ATP binding site [chemical binding]; other site 881621002570 Walker B motif; other site 881621002571 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621002572 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 881621002573 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 881621002574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002575 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 881621002576 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 881621002577 dimerization domain swap beta strand [polypeptide binding]; other site 881621002578 regulatory protein interface [polypeptide binding]; other site 881621002579 active site 881621002580 regulatory phosphorylation site [posttranslational modification]; other site 881621002581 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 881621002582 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 881621002583 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621002584 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 881621002585 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621002586 putative active site [active] 881621002587 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 881621002588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002589 hypothetical protein; Validated; Region: PRK07682 881621002590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621002591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621002592 homodimer interface [polypeptide binding]; other site 881621002593 catalytic residue [active] 881621002594 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 881621002595 FOG: CBS domain [General function prediction only]; Region: COG0517 881621002596 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_30; cd04643 881621002597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621002598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621002599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621002600 dimerization interface [polypeptide binding]; other site 881621002601 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 881621002602 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 881621002603 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 881621002604 trimer interface [polypeptide binding]; other site 881621002605 active site 881621002606 substrate binding site [chemical binding]; other site 881621002607 CoA binding site [chemical binding]; other site 881621002608 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621002609 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 881621002610 metal binding site [ion binding]; metal-binding site 881621002611 putative dimer interface [polypeptide binding]; other site 881621002612 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 881621002613 Mechanosensitive ion channel; Region: MS_channel; pfam00924 881621002614 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 881621002615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621002616 Walker A/P-loop; other site 881621002617 ATP binding site [chemical binding]; other site 881621002618 Q-loop/lid; other site 881621002619 ABC transporter signature motif; other site 881621002620 Walker B; other site 881621002621 D-loop; other site 881621002622 H-loop/switch region; other site 881621002623 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl15354 881621002624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002625 dimer interface [polypeptide binding]; other site 881621002626 conserved gate region; other site 881621002627 putative PBP binding loops; other site 881621002628 ABC-ATPase subunit interface; other site 881621002629 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 881621002630 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 881621002631 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621002632 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 881621002633 HPr interaction site; other site 881621002634 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002635 active site 881621002636 phosphorylation site [posttranslational modification] 881621002637 CutC family; Region: CutC; cl01218 881621002638 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 881621002639 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 881621002640 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 881621002641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 881621002642 Histidine kinase; Region: HisKA_3; pfam07730 881621002643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621002644 ATP binding site [chemical binding]; other site 881621002645 Mg2+ binding site [ion binding]; other site 881621002646 G-X-G motif; other site 881621002647 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621002648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621002649 active site 881621002650 phosphorylation site [posttranslational modification] 881621002651 intermolecular recognition site; other site 881621002652 dimerization interface [polypeptide binding]; other site 881621002653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 881621002654 DNA binding residues [nucleotide binding] 881621002655 dimerization interface [polypeptide binding]; other site 881621002656 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 881621002657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002658 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 881621002659 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 881621002660 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621002661 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621002662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621002663 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621002664 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 881621002665 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621002666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621002667 active site 881621002668 motif I; other site 881621002669 motif II; other site 881621002670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621002671 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621002672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621002673 DNA binding site [nucleotide binding] 881621002674 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621002675 ligand binding site [chemical binding]; other site 881621002676 dimerization interface [polypeptide binding]; other site 881621002677 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cd00578 881621002678 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621002679 trimer interface [polypeptide binding]; other site 881621002680 substrate binding site [chemical binding]; other site 881621002681 Mn binding site [ion binding]; other site 881621002682 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621002683 TPP-binding site [chemical binding]; other site 881621002684 dimer interface [polypeptide binding]; other site 881621002685 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 881621002686 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621002687 PYR/PP interface [polypeptide binding]; other site 881621002688 dimer interface [polypeptide binding]; other site 881621002689 TPP binding site [chemical binding]; other site 881621002690 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621002691 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 881621002692 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 881621002693 N- and C-terminal domain interface [polypeptide binding]; other site 881621002694 active site 881621002695 MgATP binding site [chemical binding]; other site 881621002696 catalytic site [active] 881621002697 metal binding site [ion binding]; metal-binding site 881621002698 carbohydrate binding site [chemical binding]; other site 881621002699 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 881621002700 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621002701 active site turn [active] 881621002702 phosphorylation site [posttranslational modification] 881621002703 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002704 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 881621002705 HPr interaction site; other site 881621002706 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002707 active site 881621002708 phosphorylation site [posttranslational modification] 881621002709 Putative endoglucanase; Region: Glyco_hydro_101; pfam12905 881621002710 Protein of unknown function (DUF817); Region: DUF817; cl01520 881621002711 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 881621002712 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 881621002713 GTP binding site [chemical binding]; other site 881621002714 ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of...; Region: ABC_ModC_molybdenum_transporter; cd03297 881621002715 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 881621002716 Walker A/P-loop; other site 881621002717 ATP binding site [chemical binding]; other site 881621002718 Q-loop/lid; other site 881621002719 ABC transporter signature motif; other site 881621002720 Walker B; other site 881621002721 D-loop; other site 881621002722 H-loop/switch region; other site 881621002723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621002724 dimer interface [polypeptide binding]; other site 881621002725 conserved gate region; other site 881621002726 putative PBP binding loops; other site 881621002727 ABC-ATPase subunit interface; other site 881621002728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621002729 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 881621002730 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 881621002731 dimer interface [polypeptide binding]; other site 881621002732 putative functional site; other site 881621002733 putative MPT binding site; other site 881621002734 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 881621002735 Walker A motif; other site 881621002736 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 881621002737 MoaE homodimer interface [polypeptide binding]; other site 881621002738 MoaD interaction [polypeptide binding]; other site 881621002739 active site residues [active] 881621002740 similar to molybdopterin converting factor (subunit 1), C-terminal part 881621002741 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 881621002742 trimer interface [polypeptide binding]; other site 881621002743 dimer interface [polypeptide binding]; other site 881621002744 putative active site [active] 881621002745 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 881621002746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 881621002747 FeS/SAM binding site; other site 881621002748 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 881621002749 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 881621002750 MPT binding site; other site 881621002751 trimer interface [polypeptide binding]; other site 881621002752 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 881621002753 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 881621002754 ATP binding site [chemical binding]; other site 881621002755 substrate interface [chemical binding]; other site 881621002756 similar to unknown protein, N-terminal part 881621002757 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 881621002758 active site 881621002759 catalytic residues [active] 881621002760 metal binding site [ion binding]; metal-binding site 881621002761 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 881621002762 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621002763 TPP-binding site [chemical binding]; other site 881621002764 tetramer interface [polypeptide binding]; other site 881621002765 heterodimer interface [polypeptide binding]; other site 881621002766 phosphorylation loop region [posttranslational modification] 881621002767 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621002768 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621002769 alpha subunit interface [polypeptide binding]; other site 881621002770 TPP binding site [chemical binding]; other site 881621002771 heterodimer interface [polypeptide binding]; other site 881621002772 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621002773 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 881621002774 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621002775 E3 interaction surface; other site 881621002776 lipoyl attachment site [posttranslational modification]; other site 881621002777 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621002778 E3 interaction surface; other site 881621002779 lipoyl attachment site [posttranslational modification]; other site 881621002780 e3 binding domain; Region: E3_binding; pfam02817 881621002781 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 881621002782 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 881621002783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002785 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621002786 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 881621002787 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 881621002788 NAD(P) binding site [chemical binding]; other site 881621002789 LDH/MDH dimer interface [polypeptide binding]; other site 881621002790 substrate binding site [chemical binding]; other site 881621002791 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 881621002792 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 881621002793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621002794 Probable galacturonosyltransferase; Region: PLN02867 881621002795 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 881621002796 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 881621002797 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 881621002798 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 881621002799 active site 881621002800 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 881621002801 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 881621002802 G1 box; other site 881621002803 putative GEF interaction site [polypeptide binding]; other site 881621002804 GTP/Mg2+ binding site [chemical binding]; other site 881621002805 Switch I region; other site 881621002806 G2 box; other site 881621002807 G3 box; other site 881621002808 Switch II region; other site 881621002809 G4 box; other site 881621002810 G5 box; other site 881621002811 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 881621002812 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 881621002813 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 881621002814 amidase catalytic site [active] 881621002815 Zn binding residues [ion binding]; other site 881621002816 substrate binding site [chemical binding]; other site 881621002817 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002818 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002819 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002820 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002821 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002822 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002823 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 881621002824 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 881621002825 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621002826 pyruvate carboxylase; Reviewed; Region: PRK12999 881621002827 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621002828 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621002829 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 881621002830 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 881621002831 active site 881621002832 catalytic residues [active] 881621002833 metal binding site [ion binding]; metal-binding site 881621002834 homodimer binding site [polypeptide binding]; other site 881621002835 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 881621002836 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 881621002837 carboxyltransferase (CT) interaction site; other site 881621002838 biotinylation site [posttranslational modification]; other site 881621002839 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 881621002840 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 881621002841 putative binding site residues; other site 881621002842 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621002843 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 881621002844 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 881621002845 Walker A/P-loop; other site 881621002846 ATP binding site [chemical binding]; other site 881621002847 Q-loop/lid; other site 881621002848 ABC transporter signature motif; other site 881621002849 Walker B; other site 881621002850 D-loop; other site 881621002851 H-loop/switch region; other site 881621002852 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 881621002853 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002854 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002855 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002856 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002857 Bacterial SH3 domain; Region: SH3_3; cl02551 881621002858 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 881621002859 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 881621002860 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 881621002861 Ligand binding site [chemical binding]; other site 881621002862 Putative Catalytic site [active] 881621002863 DXD motif; other site 881621002864 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 881621002865 active site 881621002866 tetramer interface [polypeptide binding]; other site 881621002867 putative glycosyltransferase TIGR03111; Region: glyc2_xrt_Gpos1 881621002868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621002869 active site 881621002870 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621002871 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621002872 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 881621002873 substrate binding site [chemical binding]; other site 881621002874 dimer interface [polypeptide binding]; other site 881621002875 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 881621002876 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621002877 putative NAD(P) binding site [chemical binding]; other site 881621002878 putative catalytic Zn binding site [ion binding]; other site 881621002879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 881621002880 active site 881621002881 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621002882 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621002883 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 881621002884 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 881621002885 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 881621002886 active site 881621002887 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 881621002888 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 881621002889 homodimer interface [polypeptide binding]; other site 881621002890 NAD binding pocket [chemical binding]; other site 881621002891 ATP binding pocket [chemical binding]; other site 881621002892 Mg binding site [ion binding]; other site 881621002893 active-site loop [active] 881621002894 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621002895 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 881621002896 P-loop; other site 881621002897 active site 881621002898 phosphorylation site [posttranslational modification] 881621002899 GMP synthase; Reviewed; Region: guaA; PRK00074 881621002900 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 881621002901 AMP/PPi binding site [chemical binding]; other site 881621002902 candidate oxyanion hole; other site 881621002903 catalytic triad [active] 881621002904 potential glutamine specificity residues [chemical binding]; other site 881621002905 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 881621002906 ATP Binding subdomain [chemical binding]; other site 881621002907 Dimerization subdomain; other site 881621002908 similar to transposase 881621002909 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 881621002910 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621002911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621002912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621002913 active site 881621002914 metal binding site [ion binding]; metal-binding site 881621002915 similar to unknown protein, N-terminal part 881621002916 similar to unknown protein, central part 881621002917 similar to unknown protein, C-terminal part 881621002918 similar to unknown protein, partial sequence 881621002919 similar to unknown protein, partial 881621002920 Partial, C-terminal part 881621002921 similar to unknown protein, N-terminal part 881621002922 MepB protein; Region: MepB; cl01985 881621002923 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 881621002924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621002925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621002926 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621002927 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 881621002928 DNA binding residues [nucleotide binding] 881621002929 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621002930 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621002931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621002932 Walker A/P-loop; other site 881621002933 ATP binding site [chemical binding]; other site 881621002934 Q-loop/lid; other site 881621002935 ABC transporter signature motif; other site 881621002936 Walker B; other site 881621002937 D-loop; other site 881621002938 H-loop/switch region; other site 881621002939 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621002940 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621002941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621002942 Walker A/P-loop; other site 881621002943 ATP binding site [chemical binding]; other site 881621002944 Q-loop/lid; other site 881621002945 ABC transporter signature motif; other site 881621002946 Walker B; other site 881621002947 D-loop; other site 881621002948 H-loop/switch region; other site 881621002949 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 881621002950 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621002951 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621002952 active site turn [active] 881621002953 phosphorylation site [posttranslational modification] 881621002954 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 881621002955 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 881621002956 NAD binding site [chemical binding]; other site 881621002957 sugar binding site [chemical binding]; other site 881621002958 divalent metal binding site [ion binding]; other site 881621002959 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621002960 dimer interface [polypeptide binding]; other site 881621002961 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621002962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621002963 putative active site [active] 881621002964 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 881621002965 HPr interaction site; other site 881621002966 glycerol kinase (GK) interaction site [polypeptide binding]; other site 881621002967 active site 881621002968 phosphorylation site [posttranslational modification] 881621002969 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621002970 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621002971 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621002972 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621002973 DNA binding residues [nucleotide binding] 881621002974 putative dimer interface [polypeptide binding]; other site 881621002975 weakly similar to inorganic pyrophosphatase,C-terminal part 881621002976 similar to beta-glucosidase, C-terminal part 881621002977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 881621002978 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621002979 oligomer interface [polypeptide binding]; other site 881621002980 active site residues [active] 881621002981 similar to unknown protein, C-terminal part 881621002982 similar to unknown protein, N-terminal part 881621002983 precorrin-2 dehydrogenase; Validated; Region: PRK06719 881621002984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621002985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621002986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621002987 short chain dehydrogenase; Provisional; Region: PRK06197 881621002988 NAD(P) binding site [chemical binding]; other site 881621002989 active site 881621002990 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 881621002991 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 881621002992 SLBB domain; Region: SLBB; pfam10531 881621002993 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621002994 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621002995 putative hexamer interface [polypeptide binding]; other site 881621002996 putative hexagonal pore; other site 881621002997 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621002998 putative hexamer interface [polypeptide binding]; other site 881621002999 putative hexagonal pore; other site 881621003000 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 881621003001 putative hexamer interface [polypeptide binding]; other site 881621003002 putative hexagonal pore; other site 881621003003 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 881621003004 G1 box; other site 881621003005 GTP/Mg2+ binding site [chemical binding]; other site 881621003006 G2 box; other site 881621003007 Switch I region; other site 881621003008 G3 box; other site 881621003009 Switch II region; other site 881621003010 G4 box; other site 881621003011 G5 box; other site 881621003012 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 881621003013 homotrimer interface [polypeptide binding]; other site 881621003014 Walker A motif; other site 881621003015 GTP binding site [chemical binding]; other site 881621003016 Walker B motif; other site 881621003017 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 881621003018 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003019 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621003020 catalytic core [active] 881621003021 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003022 Hexamer interface [polypeptide binding]; other site 881621003023 Hexagonal pore residue; other site 881621003024 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 881621003025 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 881621003026 putative hexamer interface [polypeptide binding]; other site 881621003027 putative hexagonal pore; other site 881621003028 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 881621003029 putative hexamer interface [polypeptide binding]; other site 881621003030 putative hexagonal pore; other site 881621003031 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 881621003032 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1,2-...; Region: Dehydratase_LU; cd03687 881621003033 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 881621003034 alpha-beta subunit interface [polypeptide binding]; other site 881621003035 alpha-gamma subunit interface [polypeptide binding]; other site 881621003036 active site 881621003037 substrate and K+ binding site; other site 881621003038 K+ binding site [ion binding]; other site 881621003039 cobalamin binding site [chemical binding]; other site 881621003040 Dehydratase medium subunit; Region: Dehydratase_MU; cl03516 881621003041 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 881621003042 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 881621003043 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003044 Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 881621003045 putative hexamer interface [polypeptide binding]; other site 881621003046 putative hexagonal pore; other site 881621003047 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003048 Hexamer interface [polypeptide binding]; other site 881621003049 Hexagonal pore residue; other site 881621003050 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003051 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003052 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003053 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 881621003054 Cell division protein FtsA; Region: FtsA; cl11496 881621003055 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621003056 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 881621003057 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003058 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003059 central pore; other site 881621003060 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003061 Domain of unknown function (DUF336); Region: DUF336; cl01249 881621003062 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 881621003063 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 881621003064 putative catalytic cysteine [active] 881621003065 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003066 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003067 putative active site [active] 881621003068 metal binding site [ion binding]; metal-binding site 881621003069 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 881621003070 amphipathic channel; other site 881621003071 Asn-Pro-Ala signature motifs; other site 881621003072 Acetokinase family; Region: Acetate_kinase; cl01029 881621003073 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 881621003074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621003075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003076 homodimer interface [polypeptide binding]; other site 881621003077 catalytic residue [active] 881621003078 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 881621003079 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 881621003080 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 881621003081 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 881621003082 putative active site [active] 881621003083 metal binding site [ion binding]; metal-binding site 881621003084 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 881621003085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621003086 active site 881621003087 phosphorylation site [posttranslational modification] 881621003088 intermolecular recognition site; other site 881621003089 dimerization interface [polypeptide binding]; other site 881621003090 ANTAR domain; Region: ANTAR; cl04297 881621003091 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 881621003092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 881621003093 Histidine kinase; Region: HisKA_2; cl06527 881621003094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003095 ATP binding site [chemical binding]; other site 881621003096 Mg2+ binding site [ion binding]; other site 881621003097 G-X-G motif; other site 881621003098 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 881621003099 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 881621003100 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 881621003101 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 881621003102 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 881621003103 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 881621003104 putative hexamer interface [polypeptide binding]; other site 881621003105 putative hexagonal pore; other site 881621003106 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 881621003107 putative hexamer interface [polypeptide binding]; other site 881621003108 putative hexagonal pore; other site 881621003109 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 881621003110 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 881621003111 Hexamer interface [polypeptide binding]; other site 881621003112 Hexagonal pore residue; other site 881621003113 acetaldehyde dehydrogenase (acetylating); Region: EutH_ACDH; TIGR02518 881621003114 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621003115 putative catalytic cysteine [active] 881621003116 Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 881621003117 Hexamer interface [polypeptide binding]; other site 881621003118 Putative hexagonal pore residue; other site 881621003119 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003120 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 881621003121 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003122 Propanediol utilisation protein PduL; Region: PduL; pfam06130 881621003123 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 881621003124 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 881621003125 Hexamer/Pentamer interface [polypeptide binding]; other site 881621003126 central pore; other site 881621003127 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 881621003128 Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 881621003129 putative hexamer interface [polypeptide binding]; other site 881621003130 putative hexagonal pore; other site 881621003131 Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 881621003132 putative hexamer interface [polypeptide binding]; other site 881621003133 putative hexagonal pore; other site 881621003134 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 881621003135 Cupin domain; Region: Cupin_2; cl09118 881621003136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003137 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621003138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621003139 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 881621003140 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 881621003141 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 881621003142 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 881621003143 catalytic triad [active] 881621003144 CobD/Cbib protein; Region: CobD_Cbib; cl00561 881621003145 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 881621003146 Precorrin-8X methylmutase; Region: CbiC; pfam02570 881621003147 CbiD; Region: CbiD; cl00828 881621003148 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621003149 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 881621003150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621003151 S-adenosylmethionine binding site [chemical binding]; other site 881621003152 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621003153 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 881621003154 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 881621003155 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 881621003156 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 881621003157 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621003158 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 881621003159 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 881621003160 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621003161 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 881621003162 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 881621003163 active site 881621003164 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 881621003165 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 881621003166 active site 881621003167 C-terminal domain interface [polypeptide binding]; other site 881621003168 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 881621003169 active site 881621003170 N-terminal domain interface [polypeptide binding]; other site 881621003171 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 881621003172 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 881621003173 Cobalt transport protein component CbiN; Region: CbiN; cl00842 881621003174 Cobalt transport protein; Region: CbiQ; cl00463 881621003175 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 881621003176 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621003177 Walker A/P-loop; other site 881621003178 ATP binding site [chemical binding]; other site 881621003179 Q-loop/lid; other site 881621003180 ABC transporter signature motif; other site 881621003181 Walker B; other site 881621003182 D-loop; other site 881621003183 H-loop/switch region; other site 881621003184 cobyric acid synthase; Provisional; Region: PRK00784 881621003185 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 881621003186 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 881621003187 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 881621003188 catalytic triad [active] 881621003189 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 881621003190 Protein of unknown function, DUF606; Region: DUF606; cl01273 881621003191 Protein of unknown function, DUF606; Region: DUF606; cl01273 881621003192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003194 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 881621003195 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621003196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003197 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 881621003198 NAD binding site [chemical binding]; other site 881621003199 substrate binding site [chemical binding]; other site 881621003200 putative active site [active] 881621003201 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 881621003202 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 881621003203 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621003204 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621003205 oligomer interface [polypeptide binding]; other site 881621003206 active site 881621003207 metal binding site [ion binding]; metal-binding site 881621003208 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 881621003209 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 881621003210 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 881621003211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003212 Transposase domain (DUF772); Region: DUF772; cl12084 881621003213 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 881621003214 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 881621003215 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 881621003216 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 881621003217 dimer interface [polypeptide binding]; other site 881621003218 motif 1; other site 881621003219 active site 881621003220 motif 2; other site 881621003221 motif 3; other site 881621003222 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 881621003223 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621003224 putative tRNA-binding site [nucleotide binding]; other site 881621003225 B3/4 domain; Region: B3_4; cl11458 881621003226 tRNA synthetase B5 domain; Region: B5; cl08394 881621003227 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 881621003228 dimer interface [polypeptide binding]; other site 881621003229 motif 1; other site 881621003230 motif 3; other site 881621003231 motif 2; other site 881621003232 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 881621003233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621003234 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621003235 Walker A/P-loop; other site 881621003236 ATP binding site [chemical binding]; other site 881621003237 Q-loop/lid; other site 881621003238 ABC transporter signature motif; other site 881621003239 Walker B; other site 881621003240 D-loop; other site 881621003241 H-loop/switch region; other site 881621003242 FtsX-like permease family; Region: FtsX; pfam02687 881621003243 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 881621003244 FtsX-like permease family; Region: FtsX; pfam02687 881621003245 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621003246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003247 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 881621003248 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 881621003249 ligand binding site [chemical binding]; other site 881621003250 active site 881621003251 UGI interface [polypeptide binding]; other site 881621003252 catalytic site [active] 881621003253 ribonuclease HIII; Provisional; Region: PRK00996 881621003254 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 881621003255 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 881621003256 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003257 active site 881621003258 Cell division protein ZapA; Region: ZapA; cl01146 881621003259 Colicin V production protein; Region: Colicin_V; cl00567 881621003260 hypothetical protein; Provisional; Region: PRK08609 881621003261 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 881621003262 active site 881621003263 primer binding site [nucleotide binding]; other site 881621003264 NTP binding site [chemical binding]; other site 881621003265 metal binding triad [ion binding]; metal-binding site 881621003266 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 881621003267 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 881621003268 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003269 Walker A/P-loop; other site 881621003270 ATP binding site [chemical binding]; other site 881621003271 Q-loop/lid; other site 881621003272 ABC transporter signature motif; other site 881621003273 Walker B; other site 881621003274 D-loop; other site 881621003275 H-loop/switch region; other site 881621003276 Smr domain; Region: Smr; cl02619 881621003277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621003278 catalytic residues [active] 881621003279 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 881621003280 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 881621003281 GIY-YIG motif/motif A; other site 881621003282 active site 881621003283 catalytic site [active] 881621003284 putative DNA binding site [nucleotide binding]; other site 881621003285 metal binding site [ion binding]; metal-binding site 881621003286 UvrB/uvrC motif; Region: UVR; pfam02151 881621003287 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 881621003288 aspartate kinase; Reviewed; Region: PRK06635 881621003289 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli (...; Region: AAK_AK-DapG-like; cd04246 881621003290 putative catalytic residues [active] 881621003291 putative nucleotide binding site [chemical binding]; other site 881621003292 putative aspartate binding site [chemical binding]; other site 881621003293 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 881621003294 putative allosteric regulatory site; other site 881621003295 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 881621003296 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 881621003297 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 881621003298 ribonuclease PH; Reviewed; Region: rph; PRK00173 881621003299 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 881621003300 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 881621003301 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003302 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621003303 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003304 Leucine-rich repeats; other site 881621003305 Substrate binding site [chemical binding]; other site 881621003306 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003307 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003308 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003309 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003310 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003311 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003312 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003313 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003314 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003315 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003316 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003317 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003318 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003319 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621003320 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003321 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003322 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003323 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621003324 Substrate binding site [chemical binding]; other site 881621003325 Leucine-rich repeats; other site 881621003326 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003327 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003331 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003332 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003333 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003334 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003335 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003336 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003337 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 881621003338 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003339 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003340 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003341 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003342 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003343 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003344 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003345 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003346 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003347 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003348 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003349 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003350 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003352 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003353 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003354 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003355 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003356 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 881621003357 putative catalytic site [active] 881621003358 metal binding site A [ion binding]; metal-binding site 881621003359 phosphate binding site [ion binding]; other site 881621003360 metal binding site C [ion binding]; metal-binding site 881621003361 metal binding site B [ion binding]; metal-binding site 881621003362 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003363 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621003364 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003365 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621003366 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621003367 LRR adjacent; Region: LRR_adjacent; pfam08191 881621003368 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621003369 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621003370 dimer interface [polypeptide binding]; other site 881621003371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621003372 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621003373 catalytic core [active] 881621003374 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 881621003375 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 881621003376 ATP binding site [chemical binding]; other site 881621003377 Mg++ binding site [ion binding]; other site 881621003378 motif III; other site 881621003379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621003380 nucleotide binding region [chemical binding]; other site 881621003381 ATP-binding site [chemical binding]; other site 881621003382 DbpA RNA binding domain; Region: DbpA; pfam03880 881621003383 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621003384 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 881621003385 putative active site [active] 881621003386 nucleotide binding site [chemical binding]; other site 881621003387 nudix motif; other site 881621003388 putative metal binding site [ion binding]; other site 881621003389 Sugar transport protein; Region: Sugar_transport; pfam06800 881621003390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 881621003391 classical (c) SDRs; Region: SDR_c; cd05233 881621003392 NAD(P) binding site [chemical binding]; other site 881621003393 active site 881621003394 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621003395 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621003396 DNA binding residues [nucleotide binding] 881621003397 putative dimer interface [polypeptide binding]; other site 881621003398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621003399 putative substrate translocation pore; other site 881621003400 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621003401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003402 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621003403 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621003404 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621003405 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 881621003406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621003407 DNA-binding site [nucleotide binding]; DNA binding site 881621003408 UTRA domain; Region: UTRA; cl01230 881621003409 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 881621003410 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621003411 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 881621003412 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 881621003413 active site turn [active] 881621003414 phosphorylation site [posttranslational modification] 881621003415 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621003416 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 881621003417 nudix motif; other site 881621003418 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 881621003419 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621003420 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 881621003421 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 881621003422 putative catalytic cysteine [active] 881621003423 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 881621003424 nucleotide binding site [chemical binding]; other site 881621003425 homotetrameric interface [polypeptide binding]; other site 881621003426 putative phosphate binding site [ion binding]; other site 881621003427 putative allosteric binding site; other site 881621003428 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 881621003429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003430 non-specific DNA binding site [nucleotide binding]; other site 881621003431 salt bridge; other site 881621003432 sequence-specific DNA binding site [nucleotide binding]; other site 881621003433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621003434 non-specific DNA binding site [nucleotide binding]; other site 881621003435 salt bridge; other site 881621003436 sequence-specific DNA binding site [nucleotide binding]; other site 881621003437 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621003438 active site 881621003439 trigger factor; Provisional; Region: tig; PRK01490 881621003440 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 881621003441 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 881621003442 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 881621003443 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 881621003444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621003445 Walker A motif; other site 881621003446 ATP binding site [chemical binding]; other site 881621003447 Walker B motif; other site 881621003448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621003449 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 881621003450 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003451 Catalytic site [active] 881621003452 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003453 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003454 Catalytic site [active] 881621003455 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 881621003456 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 881621003457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 881621003458 Catalytic site [active] 881621003459 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 881621003460 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 881621003461 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621003462 active site 881621003463 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 881621003464 DNA topoisomerase I; Validated; Region: PRK05582 881621003465 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 881621003466 active site 881621003467 interdomain interaction site; other site 881621003468 putative metal-binding site [ion binding]; other site 881621003469 nucleotide binding site [chemical binding]; other site 881621003470 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 881621003471 domain I; other site 881621003472 DNA binding groove [nucleotide binding] 881621003473 phosphate binding site [ion binding]; other site 881621003474 domain II; other site 881621003475 domain III; other site 881621003476 nucleotide binding site [chemical binding]; other site 881621003477 catalytic site [active] 881621003478 domain IV; other site 881621003479 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 881621003480 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 881621003481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003482 Glucose inhibited division protein A; Region: GIDA; pfam01134 881621003483 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 881621003484 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 881621003485 DNA binding site [nucleotide binding] 881621003486 Int/Topo IB signature motif; other site 881621003487 active site 881621003488 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 881621003489 active site 881621003490 HslU subunit interaction site [polypeptide binding]; other site 881621003491 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 881621003492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621003493 Walker A motif; other site 881621003494 ATP binding site [chemical binding]; other site 881621003495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003496 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621003497 transcriptional repressor CodY; Validated; Region: PRK04158 881621003498 CodY GAF-like domain; Region: CodY; pfam06018 881621003499 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 881621003500 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 881621003501 active site 881621003502 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 881621003503 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 881621003504 active site 881621003505 catalytic residues [active] 881621003506 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 881621003507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 881621003508 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 881621003509 anchoring element; other site 881621003510 dimer interface [polypeptide binding]; other site 881621003511 ATP binding site [chemical binding]; other site 881621003512 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 881621003513 active site 881621003514 putative metal-binding site [ion binding]; other site 881621003515 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 881621003516 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 881621003517 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 881621003518 CAP-like domain; other site 881621003519 Active site [active] 881621003520 primary dimer interface [polypeptide binding]; other site 881621003521 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 881621003522 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 881621003523 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 881621003524 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 881621003525 catalytic triad [active] 881621003526 catalytic triad [active] 881621003527 oxyanion hole [active] 881621003528 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 881621003529 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 881621003530 active site 881621003531 catalytic site [active] 881621003532 metal binding site [ion binding]; metal-binding site 881621003533 dimer interface [polypeptide binding]; other site 881621003534 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 881621003535 IPP transferase; Region: IPPT; cl00403 881621003536 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 881621003537 Sm1 motif; other site 881621003538 D3 - B interaction site; other site 881621003539 D1 - D2 interaction site; other site 881621003540 Hfq - Hfq interaction site; other site 881621003541 RNA binding pocket [nucleotide binding]; other site 881621003542 Sm2 motif; other site 881621003543 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 881621003544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621003545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621003546 catalytic residue [active] 881621003547 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 881621003548 DNA binding residues [nucleotide binding] 881621003549 putative dimer interface [polypeptide binding]; other site 881621003550 glutamine synthetase, type I; Region: GlnA; TIGR00653 881621003551 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 881621003552 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 881621003553 arsenical pump membrane protein; Provisional; Region: PRK15445 881621003554 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 881621003555 transmembrane helices; other site 881621003556 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621003557 LexA repressor; Validated; Region: PRK00215 881621003558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003559 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 881621003560 Catalytic site [active] 881621003561 cell division suppressor protein YneA; Provisional; Region: PRK14125 881621003562 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 881621003563 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 881621003564 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 881621003565 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 881621003566 TPP-binding site [chemical binding]; other site 881621003567 dimer interface [polypeptide binding]; other site 881621003568 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621003569 PYR/PP interface [polypeptide binding]; other site 881621003570 dimer interface [polypeptide binding]; other site 881621003571 TPP binding site [chemical binding]; other site 881621003572 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003573 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 881621003574 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 881621003575 weakly similar to arginine N-methyltransferases,C-terminal part 881621003576 weakly similar to arginine N-methyltransferases,N-terminal part 881621003577 ParB-like nuclease domain; Region: ParBc; cl02129 881621003578 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 881621003579 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 881621003580 Active Sites [active] 881621003581 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 881621003582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003583 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621003584 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 881621003585 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 881621003586 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 881621003587 putative nucleotide binding site [chemical binding]; other site 881621003588 uridine monophosphate binding site [chemical binding]; other site 881621003589 homohexameric interface [polypeptide binding]; other site 881621003590 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 881621003591 hinge region; other site 881621003592 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 881621003593 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 881621003594 catalytic residue [active] 881621003595 putative FPP diphosphate binding site; other site 881621003596 putative FPP binding hydrophobic cleft; other site 881621003597 dimer interface [polypeptide binding]; other site 881621003598 putative IPP diphosphate binding site; other site 881621003599 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 881621003600 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 881621003601 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 881621003602 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 881621003603 prolyl-tRNA synthetase; Provisional; Region: PRK09194 881621003604 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 881621003605 dimer interface [polypeptide binding]; other site 881621003606 motif 1; other site 881621003607 active site 881621003608 motif 2; other site 881621003609 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 881621003610 putative deacylase active site [active] 881621003611 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 881621003612 active site 881621003613 motif 3; other site 881621003614 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 881621003615 anticodon binding site; other site 881621003616 DNA polymerase III PolC; Validated; Region: polC; PRK00448 881621003617 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 881621003618 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 881621003619 generic binding surface II; other site 881621003620 generic binding surface I; other site 881621003621 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 881621003622 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621003623 active site 881621003624 substrate binding site [chemical binding]; other site 881621003625 catalytic site [active] 881621003626 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 881621003627 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 881621003628 NusA N-terminal domain; Region: NusA_N; pfam08529 881621003629 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 881621003630 RNA binding site [nucleotide binding]; other site 881621003631 homodimer interface [polypeptide binding]; other site 881621003632 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 881621003633 G-X-X-G motif; other site 881621003634 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 881621003635 putative RNA binding cleft [nucleotide binding]; other site 881621003636 translation initiation factor IF-2; Validated; Region: infB; PRK05306 881621003637 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003638 translation initiation factor IF-2; Region: IF-2; TIGR00487 881621003639 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 881621003640 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 881621003641 G1 box; other site 881621003642 putative GEF interaction site [polypeptide binding]; other site 881621003643 GTP/Mg2+ binding site [chemical binding]; other site 881621003644 Switch I region; other site 881621003645 G2 box; other site 881621003646 G3 box; other site 881621003647 Switch II region; other site 881621003648 G4 box; other site 881621003649 G5 box; other site 881621003650 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 881621003651 Translation-initiation factor 2; Region: IF-2; pfam11987 881621003652 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 881621003653 Ribosome-binding factor A; Region: RBFA; cl00542 881621003654 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 881621003655 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 881621003656 RNA binding site [nucleotide binding]; other site 881621003657 active site 881621003658 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 881621003659 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 881621003660 active site 881621003661 Riboflavin kinase; Region: Flavokinase; cl03312 881621003662 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 881621003663 16S/18S rRNA binding site [nucleotide binding]; other site 881621003664 S13e-L30e interaction site [polypeptide binding]; other site 881621003665 25S rRNA binding site [nucleotide binding]; other site 881621003666 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 881621003667 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 881621003668 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 881621003669 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 881621003670 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 881621003671 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 881621003672 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 881621003673 putative nucleic acid binding region [nucleotide binding]; other site 881621003674 G-X-X-G motif; other site 881621003675 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 881621003676 RNA binding site [nucleotide binding]; other site 881621003677 domain interface; other site 881621003678 GTPase RsgA; Reviewed; Region: PRK01889 881621003679 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 881621003680 GTPase/OB domain interface [polypeptide binding]; other site 881621003681 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621003682 GTP/Mg2+ binding site [chemical binding]; other site 881621003683 G4 box; other site 881621003684 G5 box; other site 881621003685 G1 box; other site 881621003686 Switch I region; other site 881621003687 G2 box; other site 881621003688 G3 box; other site 881621003689 Switch II region; other site 881621003690 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 881621003691 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 881621003692 Rhomboid family; Region: Rhomboid; cl11446 881621003693 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 881621003694 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 881621003695 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 881621003696 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621003697 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 881621003698 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 881621003699 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 881621003700 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 881621003701 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 881621003702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003703 Walker A motif; other site 881621003704 ATP binding site [chemical binding]; other site 881621003705 Walker B motif; other site 881621003706 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 881621003707 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 881621003708 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 881621003709 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 881621003710 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 881621003711 tetramer interface [polypeptide binding]; other site 881621003712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003713 catalytic residue [active] 881621003714 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 881621003715 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 881621003716 tetramer interface [polypeptide binding]; other site 881621003717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621003718 catalytic residue [active] 881621003719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 881621003720 active site residue [active] 881621003721 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 881621003722 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621003723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621003724 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621003725 active site 881621003726 elongation factor P; Validated; Region: PRK00529 881621003727 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 881621003728 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 881621003729 RNA binding site [nucleotide binding]; other site 881621003730 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 881621003731 RNA binding site [nucleotide binding]; other site 881621003732 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 881621003733 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 881621003734 carboxyltransferase (CT) interaction site; other site 881621003735 biotinylation site [posttranslational modification]; other site 881621003736 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 881621003737 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621003738 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621003739 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 881621003740 Protein of unknown function (DUF322); Region: DUF322; cl00574 881621003741 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 881621003742 putative RNA binding site [nucleotide binding]; other site 881621003743 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 881621003744 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 881621003745 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 881621003746 homodimer interface [polypeptide binding]; other site 881621003747 NADP binding site [chemical binding]; other site 881621003748 substrate binding site [chemical binding]; other site 881621003749 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 881621003750 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 881621003751 generic binding surface II; other site 881621003752 generic binding surface I; other site 881621003753 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 881621003754 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621003755 substrate binding pocket [chemical binding]; other site 881621003756 chain length determination region; other site 881621003757 substrate-Mg2+ binding site; other site 881621003758 catalytic residues [active] 881621003759 aspartate-rich region 1; other site 881621003760 active site lid residues [active] 881621003761 aspartate-rich region 2; other site 881621003762 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 881621003763 DNA-binding site [nucleotide binding]; DNA binding site 881621003764 RNA-binding motif; other site 881621003765 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 881621003766 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 881621003767 TPP-binding site; other site 881621003768 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 881621003769 PYR/PP interface [polypeptide binding]; other site 881621003770 dimer interface [polypeptide binding]; other site 881621003771 TPP binding site [chemical binding]; other site 881621003772 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003773 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 881621003774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 881621003775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621003776 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 881621003777 arginine repressor; Provisional; Region: PRK04280 881621003778 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 881621003779 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 881621003780 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 881621003781 Walker A/P-loop; other site 881621003782 ATP binding site [chemical binding]; other site 881621003783 Q-loop/lid; other site 881621003784 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 881621003785 Q-loop/lid; other site 881621003786 ABC transporter signature motif; other site 881621003787 Walker B; other site 881621003788 D-loop; other site 881621003789 H-loop/switch region; other site 881621003790 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621003791 Acetokinase family; Region: Acetate_kinase; cl01029 881621003792 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 881621003793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003795 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621003796 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 881621003797 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 881621003798 tetramer interface [polypeptide binding]; other site 881621003799 TPP-binding site [chemical binding]; other site 881621003800 heterodimer interface [polypeptide binding]; other site 881621003801 phosphorylation loop region [posttranslational modification] 881621003802 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 881621003803 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 881621003804 alpha subunit interface [polypeptide binding]; other site 881621003805 TPP binding site [chemical binding]; other site 881621003806 heterodimer interface [polypeptide binding]; other site 881621003807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 881621003808 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 881621003809 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 881621003810 E3 interaction surface; other site 881621003811 lipoyl attachment site [posttranslational modification]; other site 881621003812 e3 binding domain; Region: E3_binding; pfam02817 881621003813 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 881621003814 peptidase T-like protein; Region: PepT-like; TIGR01883 881621003815 M28, and M42; Region: Zinc_peptidase_like; cl14876 881621003816 metal binding site [ion binding]; metal-binding site 881621003817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003818 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 881621003819 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 881621003820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621003821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621003822 active site 881621003823 phosphorylation site [posttranslational modification] 881621003824 intermolecular recognition site; other site 881621003825 dimerization interface [polypeptide binding]; other site 881621003826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621003827 DNA binding site [nucleotide binding] 881621003828 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 881621003829 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621003830 dimerization interface [polypeptide binding]; other site 881621003831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621003832 dimer interface [polypeptide binding]; other site 881621003833 phosphorylation site [posttranslational modification] 881621003834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003835 ATP binding site [chemical binding]; other site 881621003836 Mg2+ binding site [ion binding]; other site 881621003837 G-X-G motif; other site 881621003838 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 881621003839 Acylphosphatase; Region: Acylphosphatase; cl00551 881621003840 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 881621003841 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 881621003842 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 881621003843 homotetramer interface [polypeptide binding]; other site 881621003844 FMN binding site [chemical binding]; other site 881621003845 homodimer contacts [polypeptide binding]; other site 881621003846 putative active site [active] 881621003847 putative substrate binding site [chemical binding]; other site 881621003848 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 881621003849 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 881621003850 active site residue [active] 881621003851 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 881621003852 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621003853 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621003854 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621003855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003856 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 881621003857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621003858 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 881621003859 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 881621003860 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 881621003861 ligand binding site [chemical binding]; other site 881621003862 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 881621003863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621003864 Walker A/P-loop; other site 881621003865 ATP binding site [chemical binding]; other site 881621003866 Q-loop/lid; other site 881621003867 ABC transporter signature motif; other site 881621003868 Walker B; other site 881621003869 D-loop; other site 881621003870 H-loop/switch region; other site 881621003871 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 881621003872 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621003873 TM-ABC transporter signature motif; other site 881621003874 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 881621003875 TM-ABC transporter signature motif; other site 881621003876 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621003877 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621003878 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 881621003879 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 881621003880 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 881621003881 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 881621003882 classical (c) SDRs; Region: SDR_c; cd05233 881621003883 NAD(P) binding site [chemical binding]; other site 881621003884 active site 881621003885 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 881621003886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621003887 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 881621003888 competence damage-inducible protein A; Provisional; Region: PRK00549 881621003889 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 881621003890 putative MPT binding site; other site 881621003891 Competence-damaged protein; Region: CinA; cl00666 881621003892 recombinase A; Provisional; Region: recA; PRK09354 881621003893 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 881621003894 hexamer interface [polypeptide binding]; other site 881621003895 Walker A motif; other site 881621003896 ATP binding site [chemical binding]; other site 881621003897 Walker B motif; other site 881621003898 phosphodiesterase; Provisional; Region: PRK12704 881621003899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621003900 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621003901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621003902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621003903 Coenzyme A binding pocket [chemical binding]; other site 881621003904 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621003905 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 881621003906 putative active site [active] 881621003907 metal binding site [ion binding]; metal-binding site 881621003908 homodimer binding site [polypeptide binding]; other site 881621003909 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621003910 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 881621003911 MutS domain I; Region: MutS_I; pfam01624 881621003912 MutS domain II; Region: MutS_II; pfam05188 881621003913 MutS family domain IV; Region: MutS_IV; pfam05190 881621003914 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 881621003915 Walker A/P-loop; other site 881621003916 ATP binding site [chemical binding]; other site 881621003917 Q-loop/lid; other site 881621003918 ABC transporter signature motif; other site 881621003919 Walker B; other site 881621003920 D-loop; other site 881621003921 H-loop/switch region; other site 881621003922 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 881621003923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621003924 ATP binding site [chemical binding]; other site 881621003925 Mg2+ binding site [ion binding]; other site 881621003926 G-X-G motif; other site 881621003927 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 881621003928 ATP binding site [chemical binding]; other site 881621003929 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 881621003930 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 881621003931 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621003932 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621003933 coenzyme A binding site [chemical binding]; other site 881621003934 active site 881621003935 catalytic residues [active] 881621003936 glycine loop; other site 881621003937 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 881621003938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 881621003939 FeS/SAM binding site; other site 881621003940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621003941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621003942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621003943 putative substrate translocation pore; other site 881621003944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621003945 similar to integrase/recombinase, C-terminal part 881621003946 similar to integrase/recombinase, N-terminal part 881621003947 Similar to transcriptional regulator, N-terminal part 881621003948 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 881621003949 partial, C-terminal part 881621003950 Putative peptidoglycan linked protein (LPXTG motif), c-terminal part 881621003951 Putative peptidoglycan linked protein (LPXTG motif), n-terminal part 881621003952 putative acyltransferase; Provisional; Region: PRK05790 881621003953 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 881621003954 dimer interface [polypeptide binding]; other site 881621003955 active site 881621003956 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 881621003957 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 881621003958 dimer interface [polypeptide binding]; other site 881621003959 active site 881621003960 VanZ like family; Region: VanZ; cl01971 881621003961 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 881621003962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621003963 Uncharacterized conserved protein [Function unknown]; Region: COG3379 881621003964 Sulfatase; Region: Sulfatase; cl10460 881621003965 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 881621003966 Domain of unknown function DUF20; Region: UPF0118; cl00465 881621003967 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 881621003968 FAD binding domain; Region: FAD_binding_4; pfam01565 881621003969 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 881621003970 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 881621003971 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 881621003972 Walker A/P-loop; other site 881621003973 ATP binding site [chemical binding]; other site 881621003974 Q-loop/lid; other site 881621003975 ABC transporter signature motif; other site 881621003976 Walker B; other site 881621003977 D-loop; other site 881621003978 H-loop/switch region; other site 881621003979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621003980 dimer interface [polypeptide binding]; other site 881621003981 conserved gate region; other site 881621003982 ABC-ATPase subunit interface; other site 881621003983 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 881621003984 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621003985 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 881621003986 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 881621003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621003988 dimer interface [polypeptide binding]; other site 881621003989 conserved gate region; other site 881621003990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 881621003991 ABC-ATPase subunit interface; other site 881621003992 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 881621003993 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 881621003994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621003995 dimer interface [polypeptide binding]; other site 881621003996 conserved gate region; other site 881621003997 putative PBP binding loops; other site 881621003998 ABC-ATPase subunit interface; other site 881621003999 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 881621004000 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 881621004001 Walker A/P-loop; other site 881621004002 ATP binding site [chemical binding]; other site 881621004003 Q-loop/lid; other site 881621004004 ABC transporter signature motif; other site 881621004005 Walker B; other site 881621004006 D-loop; other site 881621004007 H-loop/switch region; other site 881621004008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 881621004009 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 881621004010 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621004011 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 881621004012 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621004013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621004014 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621004015 ABC transporter; Region: ABC_tran_2; pfam12848 881621004016 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621004017 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 881621004018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004020 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 881621004021 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 881621004022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621004023 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 881621004024 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 881621004025 dihydrodipicolinate synthase; Region: dapA; TIGR00674 881621004026 dimer interface [polypeptide binding]; other site 881621004027 active site 881621004028 catalytic residue [active] 881621004029 aspartate kinase I; Reviewed; Region: PRK08210 881621004030 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 881621004031 nucleotide binding site [chemical binding]; other site 881621004032 substrate binding site [chemical binding]; other site 881621004033 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 881621004034 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621004035 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 881621004036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004037 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 881621004038 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621004039 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621004040 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 881621004041 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 881621004042 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 881621004043 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 881621004044 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 881621004045 AzlC protein; Region: AzlC; cl00570 881621004046 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 881621004047 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 881621004048 PPIC-type PPIASE domain; Region: Rotamase; cl08278 881621004049 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621004050 metal binding site 2 [ion binding]; metal-binding site 881621004051 putative DNA binding helix; other site 881621004052 metal binding site 1 [ion binding]; metal-binding site 881621004053 dimer interface [polypeptide binding]; other site 881621004054 structural Zn2+ binding site [ion binding]; other site 881621004055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621004056 ABC-ATPase subunit interface; other site 881621004057 dimer interface [polypeptide binding]; other site 881621004058 putative PBP binding regions; other site 881621004059 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621004060 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 881621004061 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 881621004062 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl15354 881621004063 DHHA2 domain; Region: DHHA2; pfam02833 881621004064 endonuclease IV; Provisional; Region: PRK01060 881621004065 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 881621004066 AP (apurinic/apyrimidinic) site pocket; other site 881621004067 DNA interaction; other site 881621004068 Metal-binding active site; metal-binding site 881621004069 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 881621004070 DEAD-like helicases superfamily; Region: DEXDc; smart00487 881621004071 ATP binding site [chemical binding]; other site 881621004072 Mg++ binding site [ion binding]; other site 881621004073 motif III; other site 881621004074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621004075 nucleotide binding region [chemical binding]; other site 881621004076 ATP-binding site [chemical binding]; other site 881621004077 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 881621004078 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 881621004079 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 881621004080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621004081 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 881621004082 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 881621004083 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 881621004084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 881621004085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 881621004086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 881621004087 DNA binding residues [nucleotide binding] 881621004088 DNA primase; Validated; Region: dnaG; PRK05667 881621004089 CHC2 zinc finger; Region: zf-CHC2; cl02597 881621004090 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 881621004091 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 881621004092 active site 881621004093 metal binding site [ion binding]; metal-binding site 881621004094 interdomain interaction site; other site 881621004095 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 881621004096 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 881621004097 Domain of unknown function (DUF299); Region: DUF299; cl00780 881621004098 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 881621004099 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004100 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 881621004101 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 881621004102 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 881621004103 dimer interface [polypeptide binding]; other site 881621004104 motif 1; other site 881621004105 active site 881621004106 motif 2; other site 881621004107 motif 3; other site 881621004108 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 881621004109 Recombination protein O N terminal; Region: RecO_N; pfam11967 881621004110 Recombination protein O C terminal; Region: RecO_C; pfam02565 881621004111 GTPase Era; Reviewed; Region: era; PRK00089 881621004112 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 881621004113 G1 box; other site 881621004114 GTP/Mg2+ binding site [chemical binding]; other site 881621004115 Switch I region; other site 881621004116 G2 box; other site 881621004117 Switch II region; other site 881621004118 G3 box; other site 881621004119 G4 box; other site 881621004120 G5 box; other site 881621004121 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 881621004122 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 881621004123 active site 881621004124 catalytic motif [active] 881621004125 Zn binding site [ion binding]; other site 881621004126 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 881621004127 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 881621004128 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 881621004129 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 881621004130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621004131 Zn2+ binding site [ion binding]; other site 881621004132 Mg2+ binding site [ion binding]; other site 881621004133 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 881621004134 PhoH-like protein; Region: PhoH; cl12134 881621004135 GatB domain; Region: GatB_Yqey; cl11497 881621004136 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 881621004137 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 881621004138 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 881621004139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621004140 S-adenosylmethionine binding site [chemical binding]; other site 881621004141 chaperone protein DnaJ; Provisional; Region: PRK14280 881621004142 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 881621004143 HSP70 interaction site [polypeptide binding]; other site 881621004144 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 881621004145 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 881621004146 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 881621004147 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 881621004148 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 881621004149 dimer interface [polypeptide binding]; other site 881621004150 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 881621004151 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 881621004152 HrcA protein C terminal domain; Region: HrcA; pfam01628 881621004153 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 881621004154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 881621004155 FeS/SAM binding site; other site 881621004156 HemN C-terminal region; Region: HemN_C; pfam06969 881621004157 similal to oxidoreductase, partial 881621004158 similal to oxidoreductase, partial 881621004159 GTP-binding protein LepA; Provisional; Region: PRK05433 881621004160 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 881621004161 G1 box; other site 881621004162 putative GEF interaction site [polypeptide binding]; other site 881621004163 GTP/Mg2+ binding site [chemical binding]; other site 881621004164 Switch I region; other site 881621004165 G2 box; other site 881621004166 G3 box; other site 881621004167 Switch II region; other site 881621004168 G4 box; other site 881621004169 G5 box; other site 881621004170 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 881621004171 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 881621004172 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 881621004173 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 881621004174 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 881621004175 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 881621004176 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,C-terminal part 881621004177 similar to putative integral membrane protein ComEC specifically required for DNA uptake but not for binding,N-terminal part 881621004178 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 881621004179 catalytic motif [active] 881621004180 Zn binding site [ion binding]; other site 881621004181 SLBB domain; Region: SLBB; pfam10531 881621004182 comEA protein; Region: comE; TIGR01259 881621004183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 881621004184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621004185 S-adenosylmethionine binding site [chemical binding]; other site 881621004186 Domain of unknown function DUF143; Region: DUF143; cl00519 881621004187 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 881621004188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004189 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 881621004190 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 881621004191 active site 881621004192 (T/H)XGH motif; other site 881621004193 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 881621004194 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 881621004195 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621004196 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621004197 shikimate binding site; other site 881621004198 NAD(P) binding site [chemical binding]; other site 881621004199 GTPase YqeH; Provisional; Region: PRK13796 881621004200 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 881621004201 GTP/Mg2+ binding site [chemical binding]; other site 881621004202 G4 box; other site 881621004203 G5 box; other site 881621004204 G1 box; other site 881621004205 Switch I region; other site 881621004206 G2 box; other site 881621004207 G3 box; other site 881621004208 Switch II region; other site 881621004209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621004210 motif II; other site 881621004211 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 881621004212 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 881621004213 active site 881621004214 Zn binding site [ion binding]; other site 881621004215 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621004216 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 881621004217 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 881621004218 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 881621004219 domain; Region: GreA_GreB_N; pfam03449 881621004220 C-term; Region: GreA_GreB; pfam01272 881621004221 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 881621004222 Sugar specificity; other site 881621004223 Pyrimidine base specificity; other site 881621004224 ATP-binding site [chemical binding]; other site 881621004225 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 881621004226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621004227 S-adenosylmethionine binding site [chemical binding]; other site 881621004228 YceG-like family; Region: YceG; pfam02618 881621004229 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 881621004230 dimerization interface [polypeptide binding]; other site 881621004231 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 881621004232 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621004233 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 881621004234 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 881621004235 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 881621004236 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 881621004237 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 881621004238 motif 1; other site 881621004239 active site 881621004240 motif 2; other site 881621004241 motif 3; other site 881621004242 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 881621004243 DHHA1 domain; Region: DHHA1; pfam02272 881621004244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621004245 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621004246 Walker A/P-loop; other site 881621004247 ATP binding site [chemical binding]; other site 881621004248 Q-loop/lid; other site 881621004249 ABC transporter signature motif; other site 881621004250 Walker B; other site 881621004251 D-loop; other site 881621004252 H-loop/switch region; other site 881621004253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 881621004254 FtsX-like permease family; Region: FtsX; pfam02687 881621004255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621004256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621004257 active site 881621004258 phosphorylation site [posttranslational modification] 881621004259 intermolecular recognition site; other site 881621004260 dimerization interface [polypeptide binding]; other site 881621004261 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621004262 DNA binding site [nucleotide binding] 881621004263 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 881621004264 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621004265 dimerization interface [polypeptide binding]; other site 881621004266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621004267 dimer interface [polypeptide binding]; other site 881621004268 phosphorylation site [posttranslational modification] 881621004269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621004270 ATP binding site [chemical binding]; other site 881621004271 Mg2+ binding site [ion binding]; other site 881621004272 G-X-G motif; other site 881621004273 RecD/TraA family; Region: recD_rel; TIGR01448 881621004274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621004275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621004276 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 881621004277 TPR motif; other site 881621004278 binding surface 881621004279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621004280 binding surface 881621004281 TPR motif; other site 881621004282 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621004283 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 881621004284 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 881621004285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621004286 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621004287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004288 catalytic residue [active] 881621004289 recombination factor protein RarA; Reviewed; Region: PRK13342 881621004290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621004291 Walker A motif; other site 881621004292 ATP binding site [chemical binding]; other site 881621004293 Walker B motif; other site 881621004294 arginine finger; other site 881621004295 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 881621004296 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621004297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621004298 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 881621004299 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 881621004300 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 881621004301 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 881621004302 dimer interface [polypeptide binding]; other site 881621004303 anticodon binding site; other site 881621004304 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 881621004305 homodimer interface [polypeptide binding]; other site 881621004306 motif 1; other site 881621004307 active site 881621004308 motif 2; other site 881621004309 GAD domain; Region: GAD; pfam02938 881621004310 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 881621004311 motif 3; other site 881621004312 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 881621004313 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 881621004314 dimer interface [polypeptide binding]; other site 881621004315 motif 1; other site 881621004316 active site 881621004317 motif 2; other site 881621004318 motif 3; other site 881621004319 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 881621004320 anticodon binding site; other site 881621004321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 881621004322 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004323 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004324 Bacterial SH3 domain; Region: SH3_3; cl02551 881621004325 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 881621004326 active site 881621004327 metal binding site [ion binding]; metal-binding site 881621004328 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 881621004329 putative active site [active] 881621004330 dimerization interface [polypeptide binding]; other site 881621004331 putative tRNAtyr binding site [nucleotide binding]; other site 881621004332 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 881621004333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621004334 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 881621004335 synthetase active site [active] 881621004336 NTP binding site [chemical binding]; other site 881621004337 metal binding site [ion binding]; metal-binding site 881621004338 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 881621004339 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 881621004340 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621004341 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 881621004342 DHH family; Region: DHH; pfam01368 881621004343 DHHA1 domain; Region: DHHA1; pfam02272 881621004344 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 881621004345 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 881621004346 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 881621004347 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 881621004348 Protein export membrane protein; Region: SecD_SecF; cl14618 881621004349 Protein export membrane protein; Region: SecD_SecF; cl14618 881621004350 Preprotein translocase subunit; Region: YajC; cl00806 881621004351 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 881621004352 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 881621004353 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 881621004354 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 881621004355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621004356 Walker A motif; other site 881621004357 ATP binding site [chemical binding]; other site 881621004358 Walker B motif; other site 881621004359 arginine finger; other site 881621004360 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 881621004361 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 881621004362 RuvA N terminal domain; Region: RuvA_N; pfam01330 881621004363 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 881621004364 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621004365 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621004366 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621004367 NAD binding site [chemical binding]; other site 881621004368 dimer interface [polypeptide binding]; other site 881621004369 substrate binding site [chemical binding]; other site 881621004370 Domain of unknown function DUF28; Region: DUF28; cl00361 881621004371 prephenate dehydratase; Provisional; Region: PRK11898 881621004372 Prephenate dehydratase; Region: PDT; pfam00800 881621004373 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 881621004374 putative L-Phe binding site [chemical binding]; other site 881621004375 GTPase CgtA; Reviewed; Region: obgE; PRK12297 881621004376 GTP1/OBG; Region: GTP1_OBG; pfam01018 881621004377 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 881621004378 G1 box; other site 881621004379 GTP/Mg2+ binding site [chemical binding]; other site 881621004380 Switch I region; other site 881621004381 G2 box; other site 881621004382 G3 box; other site 881621004383 Switch II region; other site 881621004384 G4 box; other site 881621004385 G5 box; other site 881621004386 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 881621004387 glycerol kinase; Provisional; Region: glpK; PRK00047 881621004388 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 881621004389 N- and C-terminal domain interface [polypeptide binding]; other site 881621004390 active site 881621004391 MgATP binding site [chemical binding]; other site 881621004392 catalytic site [active] 881621004393 metal binding site [ion binding]; metal-binding site 881621004394 glycerol binding site [chemical binding]; other site 881621004395 homotetramer interface [polypeptide binding]; other site 881621004396 homodimer interface [polypeptide binding]; other site 881621004397 FBP binding site [chemical binding]; other site 881621004398 protein IIAGlc interface [polypeptide binding]; other site 881621004399 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 881621004400 amphipathic channel; other site 881621004401 Asn-Pro-Ala signature motifs; other site 881621004402 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 881621004403 Protein of unknown function (DUF464); Region: DUF464; cl01080 881621004404 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 881621004405 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 881621004406 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 881621004407 homodimer interface [polypeptide binding]; other site 881621004408 oligonucleotide binding site [chemical binding]; other site 881621004409 septum site-determining protein MinD; Region: minD_bact; TIGR01968 881621004410 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 881621004411 Switch I; other site 881621004412 Switch II; other site 881621004413 septum formation inhibitor; Reviewed; Region: minC; PRK00513 881621004414 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 881621004415 rod shape-determining protein MreD; Region: MreD; cl01087 881621004416 rod shape-determining protein MreC; Provisional; Region: PRK13922 881621004417 rod shape-determining protein MreC; Region: MreC; pfam04085 881621004418 rod shape-determining protein MreB; Provisional; Region: PRK13927 881621004419 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621004420 ATP binding site [chemical binding]; other site 881621004421 profilin binding site; other site 881621004422 hypothetical protein; Reviewed; Region: PRK00024 881621004423 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 881621004424 MPN+ (JAMM) motif; other site 881621004425 Zinc-binding site [ion binding]; other site 881621004426 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 881621004427 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 881621004428 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 881621004429 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 881621004430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621004431 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621004432 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 881621004433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 881621004434 active site 881621004435 HIGH motif; other site 881621004436 nucleotide binding site [chemical binding]; other site 881621004437 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 881621004438 active site 881621004439 KMSKS motif; other site 881621004440 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 881621004441 tRNA binding surface [nucleotide binding]; other site 881621004442 anticodon binding site; other site 881621004443 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 881621004444 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 881621004445 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 881621004446 inhibitor-cofactor binding pocket; inhibition site 881621004447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004448 catalytic residue [active] 881621004449 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 881621004450 dimer interface [polypeptide binding]; other site 881621004451 active site 881621004452 Schiff base residues; other site 881621004453 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 881621004454 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 881621004455 active site 881621004456 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 881621004457 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 881621004458 domain interfaces; other site 881621004459 active site 881621004460 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 881621004461 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 881621004462 tRNA; other site 881621004463 putative tRNA binding site [nucleotide binding]; other site 881621004464 putative NADP binding site [chemical binding]; other site 881621004465 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 881621004466 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 881621004467 G1 box; other site 881621004468 GTP/Mg2+ binding site [chemical binding]; other site 881621004469 Switch I region; other site 881621004470 G2 box; other site 881621004471 G3 box; other site 881621004472 Switch II region; other site 881621004473 G4 box; other site 881621004474 G5 box; other site 881621004475 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 881621004476 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 881621004477 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 881621004478 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 881621004479 active site 881621004480 dimer interface [polypeptide binding]; other site 881621004481 motif 1; other site 881621004482 motif 2; other site 881621004483 motif 3; other site 881621004484 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 881621004485 anticodon binding site; other site 881621004486 primosomal protein DnaI; Reviewed; Region: PRK08939 881621004487 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 881621004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621004489 Walker A motif; other site 881621004490 ATP binding site [chemical binding]; other site 881621004491 Walker B motif; other site 881621004492 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 881621004493 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 881621004494 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 881621004495 ATP cone domain; Region: ATP-cone; pfam03477 881621004496 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 881621004497 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 881621004498 CoA-binding site [chemical binding]; other site 881621004499 ATP-binding [chemical binding]; other site 881621004500 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 881621004501 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 881621004502 DNA binding site [nucleotide binding] 881621004503 catalytic residue [active] 881621004504 H2TH interface [polypeptide binding]; other site 881621004505 putative catalytic residues [active] 881621004506 turnover-facilitating residue; other site 881621004507 intercalation triad [nucleotide binding]; other site 881621004508 8OG recognition residue [nucleotide binding]; other site 881621004509 putative reading head residues; other site 881621004510 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 881621004511 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621004512 DNA polymerase I; Provisional; Region: PRK05755 881621004513 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621004514 active site 881621004515 metal binding site 1 [ion binding]; metal-binding site 881621004516 putative 5' ssDNA interaction site; other site 881621004517 metal binding site 3; metal-binding site 881621004518 metal binding site 2 [ion binding]; metal-binding site 881621004519 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621004520 putative DNA binding site [nucleotide binding]; other site 881621004521 putative metal binding site [ion binding]; other site 881621004522 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 881621004523 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 881621004524 active site 881621004525 DNA binding site [nucleotide binding] 881621004526 catalytic site [active] 881621004527 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 881621004528 isocitrate dehydrogenase; Validated; Region: PRK07362 881621004529 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes...; Region: BSuCS-II_like; cd06110 881621004530 dimer interface [polypeptide binding]; other site 881621004531 Citrate synthase; Region: Citrate_synt; pfam00285 881621004532 active site 881621004533 citrylCoA binding site [chemical binding]; other site 881621004534 oxalacetate/citrate binding site [chemical binding]; other site 881621004535 coenzyme A binding site [chemical binding]; other site 881621004536 catalytic triad [active] 881621004537 Protein of unknown function (DUF441); Region: DUF441; cl01041 881621004538 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 881621004539 pyruvate kinase; Provisional; Region: PRK06354 881621004540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 881621004541 domain interfaces; other site 881621004542 active site 881621004543 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621004544 6-phosphofructokinase; Provisional; Region: PRK03202 881621004545 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 881621004546 active site 881621004547 ADP/pyrophosphate binding site [chemical binding]; other site 881621004548 dimerization interface [polypeptide binding]; other site 881621004549 allosteric effector site; other site 881621004550 fructose-1,6-bisphosphate binding site; other site 881621004551 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 881621004552 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 881621004553 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 881621004554 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 881621004555 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 881621004556 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 881621004557 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 881621004558 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 881621004559 generic binding surface I; other site 881621004560 generic binding surface II; other site 881621004561 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 881621004562 DHH family; Region: DHH; pfam01368 881621004563 DHHA1 domain; Region: DHHA1; pfam02272 881621004564 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 881621004565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621004566 DNA-binding site [nucleotide binding]; DNA binding site 881621004567 DRTGG domain; Region: DRTGG; cl12147 881621004568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 881621004569 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 881621004570 active site 2 [active] 881621004571 active site 1 [active] 881621004572 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621004573 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 881621004574 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 881621004575 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 881621004576 active site 881621004577 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 881621004578 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 881621004579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004580 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621004581 Ligand Binding Site [chemical binding]; other site 881621004582 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621004583 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 881621004584 substrate binding pocket [chemical binding]; other site 881621004585 catalytic triad [active] 881621004586 Acetokinase family; Region: Acetate_kinase; cl01029 881621004587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621004588 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 881621004589 dimer interface [polypeptide binding]; other site 881621004590 catalytic triad [active] 881621004591 peroxidatic and resolving cysteines [active] 881621004592 RDD family; Region: RDD; cl00746 881621004593 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 881621004594 tandem repeat interface [polypeptide binding]; other site 881621004595 oligomer interface [polypeptide binding]; other site 881621004596 active site residues [active] 881621004597 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621004598 ornithine carbamoyltransferase; Provisional; Region: PRK00779 881621004599 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621004600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004601 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 881621004602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 881621004603 inhibitor-cofactor binding pocket; inhibition site 881621004604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004605 catalytic residue [active] 881621004606 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 881621004607 nucleotide binding site [chemical binding]; other site 881621004608 N-acetyl-L-glutamate binding site [chemical binding]; other site 881621004609 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 881621004610 heterotetramer interface [polypeptide binding]; other site 881621004611 active site pocket [active] 881621004612 cleavage site 881621004613 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 881621004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004615 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 881621004616 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 881621004617 THUMP domain; Region: THUMP; cl12076 881621004618 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 881621004619 Ligand Binding Site [chemical binding]; other site 881621004620 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621004621 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621004622 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621004623 catalytic residue [active] 881621004624 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 881621004625 GAF domain; Region: GAF; cl00853 881621004626 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 881621004627 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 881621004628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004629 RNA binding surface [nucleotide binding]; other site 881621004630 truncated, N-terminal part 881621004631 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 881621004632 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 881621004633 active site 881621004634 HIGH motif; other site 881621004635 dimer interface [polypeptide binding]; other site 881621004636 KMSKS motif; other site 881621004637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621004638 RNA binding surface [nucleotide binding]; other site 881621004639 catabolite control protein A; Region: ccpA; TIGR01481 881621004640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621004641 DNA binding site [nucleotide binding] 881621004642 domain linker motif; other site 881621004643 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 881621004644 dimerization interface [polypeptide binding]; other site 881621004645 effector binding site; other site 881621004646 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 881621004647 Chorismate mutase type II; Region: CM_2; cl00693 881621004648 NeuB family; Region: NeuB; cl00496 881621004649 YtxH-like protein; Region: YtxH; cl02079 881621004650 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 881621004651 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 881621004652 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 881621004653 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 881621004654 dimer interface [polypeptide binding]; other site 881621004655 decamer (pentamer of dimers) interface [polypeptide binding]; other site 881621004656 catalytic triad [active] 881621004657 peroxidatic and resolving cysteines [active] 881621004658 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 881621004659 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621004660 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621004661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621004662 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 881621004663 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621004664 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 881621004665 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 881621004666 putative tRNA-binding site [nucleotide binding]; other site 881621004667 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 881621004668 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621004669 catalytic residues [active] 881621004670 Protein of unknown function (DUF1673); Region: DUF1673; pfam07895 881621004671 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 881621004672 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 881621004673 oligomer interface [polypeptide binding]; other site 881621004674 active site 881621004675 metal binding site [ion binding]; metal-binding site 881621004676 Predicted small secreted protein [Function unknown]; Region: COG5584 881621004677 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621004678 methionine cluster; other site 881621004679 active site 881621004680 phosphorylation site [posttranslational modification] 881621004681 metal binding site [ion binding]; metal-binding site 881621004682 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621004683 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 881621004684 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 881621004685 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621004686 active site 881621004687 P-loop; other site 881621004688 phosphorylation site [posttranslational modification] 881621004689 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621004690 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621004691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621004692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621004693 PRD domain; Region: PRD; pfam00874 881621004694 PRD domain; Region: PRD; pfam00874 881621004695 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621004696 P-loop; other site 881621004697 active site 881621004698 phosphorylation site [posttranslational modification] 881621004699 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621004700 active site 881621004701 phosphorylation site [posttranslational modification] 881621004702 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621004703 putative homotetramer interface [polypeptide binding]; other site 881621004704 putative homodimer interface [polypeptide binding]; other site 881621004705 putative allosteric switch controlling residues; other site 881621004706 putative metal binding site [ion binding]; other site 881621004707 putative homodimer-homodimer interface [polypeptide binding]; other site 881621004708 similar to unknown protein, C-terminal part 881621004709 similar to unknown protein, N-terminal part 881621004710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621004711 Phosphotransferase enzyme family; Region: APH; pfam01636 881621004712 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 881621004713 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621004714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004715 putative substrate translocation pore; other site 881621004716 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621004717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621004718 Transposase, Mutator family; Region: Transposase_mut; pfam00872 881621004719 MULE transposase domain; Region: MULE; pfam10551 881621004720 similar to unknown protein 881621004721 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 881621004722 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 881621004723 homodimer interface [polypeptide binding]; other site 881621004724 substrate-cofactor binding pocket; other site 881621004725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004726 catalytic residue [active] 881621004727 dipeptidase PepV; Reviewed; Region: PRK07318 881621004728 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 881621004729 active site 881621004730 metal binding site [ion binding]; metal-binding site 881621004731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 881621004732 nudix motif; other site 881621004733 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 881621004734 putative substrate binding site [chemical binding]; other site 881621004735 putative ATP binding site [chemical binding]; other site 881621004736 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621004737 active site 881621004738 stage V sporulation protein B; Region: spore_V_B; TIGR02900 881621004739 MatE; Region: MatE; cl10513 881621004740 MatE; Region: MatE; cl10513 881621004741 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 881621004742 substrate binding site [chemical binding]; other site 881621004743 active site 881621004744 catalytic residues [active] 881621004745 heterodimer interface [polypeptide binding]; other site 881621004746 tryptophan synthase, beta chain; Region: PLN02618 881621004747 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 881621004748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004749 catalytic residue [active] 881621004750 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 881621004751 active site 881621004752 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 881621004753 active site 881621004754 ribulose/triose binding site [chemical binding]; other site 881621004755 phosphate binding site [ion binding]; other site 881621004756 substrate (anthranilate) binding pocket [chemical binding]; other site 881621004757 product (indole) binding pocket [chemical binding]; other site 881621004758 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 881621004759 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621004760 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621004761 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621004762 Glutamine amidotransferase class-I; Region: GATase; pfam00117 881621004763 glutamine binding [chemical binding]; other site 881621004764 catalytic triad [active] 881621004765 anthranilate synthase component I; Provisional; Region: PRK13570 881621004766 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 881621004767 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621004768 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 881621004769 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 881621004770 putative catalytic cysteine [active] 881621004771 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 881621004772 putative active site [active] 881621004773 metal binding site [ion binding]; metal-binding site 881621004774 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621004775 dimer interface [polypeptide binding]; other site 881621004776 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621004777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621004778 Walker A/P-loop; other site 881621004779 ATP binding site [chemical binding]; other site 881621004780 Q-loop/lid; other site 881621004781 ABC transporter signature motif; other site 881621004782 Walker B; other site 881621004783 D-loop; other site 881621004784 H-loop/switch region; other site 881621004785 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 881621004786 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 881621004787 putative dimer interface [polypeptide binding]; other site 881621004788 catalytic triad [active] 881621004789 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 881621004790 aconitate hydratase; Validated; Region: PRK09277 881621004791 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 881621004792 substrate binding site [chemical binding]; other site 881621004793 ligand binding site [chemical binding]; other site 881621004794 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 881621004795 substrate binding site [chemical binding]; other site 881621004796 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621004797 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 881621004798 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 881621004799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621004800 ATP binding site [chemical binding]; other site 881621004801 putative Mg++ binding site [ion binding]; other site 881621004802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621004803 nucleotide binding region [chemical binding]; other site 881621004804 ATP-binding site [chemical binding]; other site 881621004805 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 881621004806 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 881621004807 Walker A/P-loop; other site 881621004808 ATP binding site [chemical binding]; other site 881621004809 Q-loop/lid; other site 881621004810 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 881621004811 ABC transporter signature motif; other site 881621004812 Walker B; other site 881621004813 D-loop; other site 881621004814 H-loop/switch region; other site 881621004815 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621004816 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621004817 active site 881621004818 metal binding site [ion binding]; metal-binding site 881621004819 DNA binding site [nucleotide binding] 881621004820 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 881621004821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 881621004822 putative acyl-acceptor binding pocket; other site 881621004823 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 881621004824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621004825 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621004826 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 881621004827 Walker A/P-loop; other site 881621004828 ATP binding site [chemical binding]; other site 881621004829 Q-loop/lid; other site 881621004830 ABC transporter signature motif; other site 881621004831 Walker B; other site 881621004832 D-loop; other site 881621004833 H-loop/switch region; other site 881621004834 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621004835 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 881621004836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621004837 Walker A/P-loop; other site 881621004838 ATP binding site [chemical binding]; other site 881621004839 Q-loop/lid; other site 881621004840 ABC transporter signature motif; other site 881621004841 Walker B; other site 881621004842 D-loop; other site 881621004843 H-loop/switch region; other site 881621004844 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621004845 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621004846 active site 881621004847 active site 881621004848 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621004849 active site 881621004850 similar to peptidoglycan hydrolase (phage related),C-terminal part unknown 881621004851 similar to peptidoglycan hydrolase (phage related),internal part 881621004852 similar to peptidoglycan hydrolase (phage related),N-terminal part 881621004853 Bacteriophage holin; Region: Phage_holin_1; cl02344 881621004854 elongation factor Ts; Provisional; Region: tsf; PRK09377 881621004855 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 881621004856 Elongation factor TS; Region: EF_TS; pfam00889 881621004857 Elongation factor TS; Region: EF_TS; pfam00889 881621004858 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 881621004859 rRNA interaction site [nucleotide binding]; other site 881621004860 S8 interaction site; other site 881621004861 putative laminin-1 binding site; other site 881621004862 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 881621004863 T5orf172 domain; Region: T5orf172; cl11176 881621004864 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 881621004865 active site 881621004866 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621004867 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621004868 putative active site [active] 881621004869 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 881621004870 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 881621004871 putative active site [active] 881621004872 Uncharacterized conserved protein [Function unknown]; Region: COG3589 881621004873 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 881621004874 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621004875 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621004876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621004877 Coenzyme A binding pocket [chemical binding]; other site 881621004878 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 881621004879 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 881621004880 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621004881 HIGH motif; other site 881621004882 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 881621004883 active site 881621004884 KMSKS motif; other site 881621004885 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 881621004886 tRNA binding surface [nucleotide binding]; other site 881621004887 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 881621004888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 881621004889 FeS/SAM binding site; other site 881621004890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621004891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621004892 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 881621004893 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 881621004894 active site 881621004895 dimer interface [polypeptide binding]; other site 881621004896 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 881621004897 Ligand Binding Site [chemical binding]; other site 881621004898 Molecular Tunnel; other site 881621004899 S-adenosylmethionine synthetase; Validated; Region: PRK05250 881621004900 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 881621004901 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 881621004902 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 881621004903 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 881621004904 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621004905 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 881621004906 NAD binding site [chemical binding]; other site 881621004907 dimer interface [polypeptide binding]; other site 881621004908 substrate binding site [chemical binding]; other site 881621004909 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 881621004910 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 881621004911 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 881621004912 nudix motif; other site 881621004913 Domain of unknown function DUF37; Region: DUF37; cl00506 881621004914 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 881621004915 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621004916 metal binding site [ion binding]; metal-binding site 881621004917 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 881621004918 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 881621004919 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 881621004920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 881621004921 substrate binding site [chemical binding]; other site 881621004922 oxyanion hole (OAH) forming residues; other site 881621004923 trimer interface [polypeptide binding]; other site 881621004924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621004925 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 881621004926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621004927 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 881621004928 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 881621004929 dimer interface [polypeptide binding]; other site 881621004930 tetramer interface [polypeptide binding]; other site 881621004931 PYR/PP interface [polypeptide binding]; other site 881621004932 TPP binding site [chemical binding]; other site 881621004933 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 881621004934 TPP-binding site; other site 881621004935 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 881621004936 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621004937 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 881621004938 UbiA prenyltransferase family; Region: UbiA; cl00337 881621004939 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 881621004940 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 881621004941 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 881621004942 FAD binding site [chemical binding]; other site 881621004943 cystathionine beta-lyase; Provisional; Region: PRK08064 881621004944 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621004945 homodimer interface [polypeptide binding]; other site 881621004946 substrate-cofactor binding pocket; other site 881621004947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004948 catalytic residue [active] 881621004949 cystathionine gamma-synthase; Reviewed; Region: PRK08247 881621004950 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 881621004951 homodimer interface [polypeptide binding]; other site 881621004952 substrate-cofactor binding pocket; other site 881621004953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004954 catalytic residue [active] 881621004955 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 881621004956 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 881621004957 THF binding site; other site 881621004958 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 881621004959 substrate binding site [chemical binding]; other site 881621004960 THF binding site; other site 881621004961 zinc-binding site [ion binding]; other site 881621004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621004963 putative substrate translocation pore; other site 881621004964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621004965 metal binding site 2 [ion binding]; metal-binding site 881621004966 putative DNA binding helix; other site 881621004967 metal binding site 1 [ion binding]; metal-binding site 881621004968 dimer interface [polypeptide binding]; other site 881621004969 structural Zn2+ binding site [ion binding]; other site 881621004970 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 881621004971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621004972 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 881621004973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 881621004974 inhibitor-cofactor binding pocket; inhibition site 881621004975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621004976 catalytic residue [active] 881621004977 Predicted membrane protein [Function unknown]; Region: COG4129 881621004978 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 881621004979 Protein of unknown function (DUF402); Region: DUF402; cl00979 881621004980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 881621004981 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 881621004982 putative NAD(P) binding site [chemical binding]; other site 881621004983 active site 881621004984 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 881621004985 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621004986 minor groove reading motif; other site 881621004987 helix-hairpin-helix signature motif; other site 881621004988 substrate binding pocket [chemical binding]; other site 881621004989 active site 881621004990 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 881621004991 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 881621004992 DNA binding and oxoG recognition site [nucleotide binding] 881621004993 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 881621004994 Transposase domain (DUF772); Region: DUF772; cl12084 881621004995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 881621004996 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 881621004997 trimer interface [polypeptide binding]; other site 881621004998 active site 881621004999 RecX family; Region: RecX; cl00936 881621005000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005001 TIGR01777 family protein; Region: yfcH 881621005002 NAD(P) binding site [chemical binding]; other site 881621005003 active site 881621005004 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621005005 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 881621005006 Uncharacterized conserved protein [Function unknown]; Region: COG2898 881621005007 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 881621005008 VanZ like family; Region: VanZ; cl01971 881621005009 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621005010 Cation efflux family; Region: Cation_efflux; cl00316 881621005011 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621005012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621005013 PAS fold; Region: PAS_4; pfam08448 881621005014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 881621005015 putative active site [active] 881621005016 heme pocket [chemical binding]; other site 881621005017 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 881621005018 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 881621005019 active site 881621005020 metal binding site [ion binding]; metal-binding site 881621005021 TRAM domain; Region: TRAM; cl01282 881621005022 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 881621005023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621005024 S-adenosylmethionine binding site [chemical binding]; other site 881621005025 OsmC-like protein; Region: OsmC; cl00767 881621005026 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 881621005027 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 881621005028 Substrate-binding site [chemical binding]; other site 881621005029 Substrate specificity [chemical binding]; other site 881621005030 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 881621005031 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 881621005032 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 881621005033 methionine aminopeptidase; Reviewed; Region: PRK07281 881621005034 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 881621005035 active site 881621005036 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621005037 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 881621005038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621005039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621005040 putative substrate translocation pore; other site 881621005041 rod-share determining protein MreBH; Provisional; Region: PRK13929 881621005042 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621005043 ATP binding site [chemical binding]; other site 881621005044 Cell division protein FtsA; Region: FtsA; cl11496 881621005045 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005046 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621005047 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005048 Substrate binding site [chemical binding]; other site 881621005049 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005050 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005051 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005052 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005053 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005054 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005055 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621005056 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621005057 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005058 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005059 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621005060 LRR adjacent; Region: LRR_adjacent; pfam08191 881621005061 Uncharacterized conserved protein [Function unknown]; Region: COG4748 881621005062 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 881621005063 Uncharacterized conserved protein [Function unknown]; Region: COG3589 881621005064 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 881621005065 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621005066 methionine cluster; other site 881621005067 active site 881621005068 phosphorylation site [posttranslational modification] 881621005069 metal binding site [ion binding]; metal-binding site 881621005070 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621005071 active site 881621005072 P-loop; other site 881621005073 phosphorylation site [posttranslational modification] 881621005074 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 881621005075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621005076 Walker A motif; other site 881621005077 ATP binding site [chemical binding]; other site 881621005078 Walker B motif; other site 881621005079 arginine finger; other site 881621005080 Transcriptional antiterminator [Transcription]; Region: COG3933 881621005081 PRD domain; Region: PRD; pfam00874 881621005082 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621005083 active pocket/dimerization site; other site 881621005084 active site 881621005085 phosphorylation site [posttranslational modification] 881621005086 PRD domain; Region: PRD; pfam00874 881621005087 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621005088 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 881621005089 ATP binding site [chemical binding]; other site 881621005090 putative Mg++ binding site [ion binding]; other site 881621005091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005092 nucleotide binding region [chemical binding]; other site 881621005093 ATP-binding site [chemical binding]; other site 881621005094 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005095 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621005096 Walker A/P-loop; other site 881621005097 ATP binding site [chemical binding]; other site 881621005098 Q-loop/lid; other site 881621005099 ABC transporter signature motif; other site 881621005100 Walker B; other site 881621005101 D-loop; other site 881621005102 H-loop/switch region; other site 881621005103 Predicted transcriptional regulators [Transcription]; Region: COG1725 881621005104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621005105 DNA-binding site [nucleotide binding]; DNA binding site 881621005106 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621005109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621005110 DNA binding site [nucleotide binding] 881621005111 domain linker motif; other site 881621005112 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621005113 dimerization interface [polypeptide binding]; other site 881621005114 ligand binding site [chemical binding]; other site 881621005115 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 881621005116 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 881621005117 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 881621005118 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 881621005119 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 881621005120 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621005121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621005122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621005123 dimer interface [polypeptide binding]; other site 881621005124 conserved gate region; other site 881621005125 putative PBP binding loops; other site 881621005126 ABC-ATPase subunit interface; other site 881621005127 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621005128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621005129 dimer interface [polypeptide binding]; other site 881621005130 conserved gate region; other site 881621005131 putative PBP binding loops; other site 881621005132 ABC-ATPase subunit interface; other site 881621005133 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 881621005134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005136 NAD(P) binding pocket [chemical binding]; other site 881621005137 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 881621005138 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 881621005139 active site 881621005140 dimer interface [polypeptide binding]; other site 881621005141 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 881621005142 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 881621005143 active site 881621005144 FMN binding site [chemical binding]; other site 881621005145 substrate binding site [chemical binding]; other site 881621005146 3Fe-4S cluster binding site [ion binding]; other site 881621005147 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 881621005148 domain interface; other site 881621005149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621005150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005151 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621005152 putative dimerization interface [polypeptide binding]; other site 881621005153 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621005154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621005155 Coenzyme A binding pocket [chemical binding]; other site 881621005156 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 881621005157 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 881621005158 putative active site [active] 881621005159 metal binding site [ion binding]; metal-binding site 881621005160 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621005161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 881621005162 substrate binding pocket [chemical binding]; other site 881621005163 membrane-bound complex binding site; other site 881621005164 hinge residues; other site 881621005165 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005166 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621005167 Walker A/P-loop; other site 881621005168 ATP binding site [chemical binding]; other site 881621005169 Q-loop/lid; other site 881621005170 ABC transporter signature motif; other site 881621005171 Walker B; other site 881621005172 D-loop; other site 881621005173 H-loop/switch region; other site 881621005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621005175 dimer interface [polypeptide binding]; other site 881621005176 conserved gate region; other site 881621005177 putative PBP binding loops; other site 881621005178 ABC-ATPase subunit interface; other site 881621005179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 881621005180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621005181 ATP binding site [chemical binding]; other site 881621005182 Mg2+ binding site [ion binding]; other site 881621005183 G-X-G motif; other site 881621005184 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 881621005185 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 881621005186 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 881621005187 active site 881621005188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 881621005189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 881621005190 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 881621005191 putative NAD(P) binding site [chemical binding]; other site 881621005192 active site 881621005193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621005194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621005195 active site 881621005196 phosphorylation site [posttranslational modification] 881621005197 intermolecular recognition site; other site 881621005198 dimerization interface [polypeptide binding]; other site 881621005199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621005200 DNA binding site [nucleotide binding] 881621005201 FtsX-like permease family; Region: FtsX; pfam02687 881621005202 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621005203 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621005204 Walker A/P-loop; other site 881621005205 ATP binding site [chemical binding]; other site 881621005206 Q-loop/lid; other site 881621005207 ABC transporter signature motif; other site 881621005208 Walker B; other site 881621005209 D-loop; other site 881621005210 H-loop/switch region; other site 881621005211 Predicted amidohydrolase [General function prediction only]; Region: COG0388 881621005212 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 881621005213 active site 881621005214 catalytic triad [active] 881621005215 dimer interface [polypeptide binding]; other site 881621005216 shikimate kinase; Reviewed; Region: aroK; PRK00131 881621005217 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 881621005218 ADP binding site [chemical binding]; other site 881621005219 magnesium binding site [ion binding]; other site 881621005220 putative shikimate binding site; other site 881621005221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 881621005222 TRAM domain; Region: TRAM; cl01282 881621005223 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 881621005224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621005225 putative lipid kinase; Reviewed; Region: PRK13337 881621005226 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621005227 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621005228 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 881621005229 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 881621005230 GatB domain; Region: GatB_Yqey; cl11497 881621005231 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 881621005232 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 881621005233 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 881621005234 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 881621005235 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 881621005236 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 881621005237 nucleotide binding pocket [chemical binding]; other site 881621005238 K-X-D-G motif; other site 881621005239 catalytic site [active] 881621005240 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 881621005241 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 881621005242 Dimer interface [polypeptide binding]; other site 881621005243 BRCT sequence motif; other site 881621005244 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 881621005245 UvrD/REP helicase; Region: UvrD-helicase; cl14126 881621005246 Predicted phosphate-binding enzymes, TIM-barrel fold [General function prediction only]; Region: COG1646 881621005247 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between sn-glycerol-1-...; Region: PcrB_like; cd02812 881621005248 substrate binding site [chemical binding]; other site 881621005249 putative active site [active] 881621005250 dimer interface [polypeptide binding]; other site 881621005251 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 881621005252 Trp repressor protein; Region: Trp_repressor; cl01121 881621005253 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 881621005254 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 881621005255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621005256 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 881621005257 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 881621005258 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 881621005259 purine monophosphate binding site [chemical binding]; other site 881621005260 dimer interface [polypeptide binding]; other site 881621005261 putative catalytic residues [active] 881621005262 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 881621005263 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 881621005264 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 881621005265 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 881621005266 active site 881621005267 substrate binding site [chemical binding]; other site 881621005268 cosubstrate binding site; other site 881621005269 catalytic site [active] 881621005270 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 881621005271 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 881621005272 dimerization interface [polypeptide binding]; other site 881621005273 putative ATP binding site [chemical binding]; other site 881621005274 amidophosphoribosyltransferase; Provisional; Region: PRK06781 881621005275 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 881621005276 active site 881621005277 tetramer interface [polypeptide binding]; other site 881621005278 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621005279 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 881621005280 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 881621005281 dimerization interface [polypeptide binding]; other site 881621005282 ATP binding site [chemical binding]; other site 881621005283 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 881621005284 dimerization interface [polypeptide binding]; other site 881621005285 ATP binding site [chemical binding]; other site 881621005286 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 881621005287 putative active site [active] 881621005288 catalytic triad [active] 881621005289 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 881621005290 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 881621005291 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 881621005292 ATP binding site [chemical binding]; other site 881621005293 active site 881621005294 substrate binding site [chemical binding]; other site 881621005295 adenylosuccinate lyase; Provisional; Region: PRK07492 881621005296 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 881621005297 tetramer interface [polypeptide binding]; other site 881621005298 active site 881621005299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005300 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 881621005301 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621005302 AIR carboxylase; Region: AIRC; cl00310 881621005303 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621005304 hypothetical protein; Provisional; Region: PRK04164 881621005305 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 881621005306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621005307 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621005309 Walker A/P-loop; other site 881621005310 ATP binding site [chemical binding]; other site 881621005311 Q-loop/lid; other site 881621005312 ABC transporter signature motif; other site 881621005313 Walker B; other site 881621005314 D-loop; other site 881621005315 H-loop/switch region; other site 881621005316 peptidase T; Region: peptidase-T; TIGR01882 881621005317 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 881621005318 metal binding site [ion binding]; metal-binding site 881621005319 dimer interface [polypeptide binding]; other site 881621005320 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 881621005321 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 881621005322 active site 881621005323 DNA binding site [nucleotide binding] 881621005324 putative phosphate binding site [ion binding]; other site 881621005325 putative catalytic site [active] 881621005326 metal binding site A [ion binding]; metal-binding site 881621005327 AP binding site [nucleotide binding]; other site 881621005328 metal binding site B [ion binding]; metal-binding site 881621005329 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 881621005330 23S rRNA binding site [nucleotide binding]; other site 881621005331 L21 binding site [polypeptide binding]; other site 881621005332 L13 binding site [polypeptide binding]; other site 881621005333 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 881621005334 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 881621005335 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 881621005336 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 881621005337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621005338 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 881621005339 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 881621005340 RimM N-terminal domain; Region: RimM; pfam01782 881621005341 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 881621005342 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 881621005343 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 881621005344 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 881621005345 catalytic triad [active] 881621005346 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 881621005347 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 881621005348 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 881621005349 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 881621005350 signal recognition particle protein; Provisional; Region: PRK10867 881621005351 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 881621005352 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005353 P loop; other site 881621005354 GTP binding site [chemical binding]; other site 881621005355 Signal peptide binding domain; Region: SRP_SPB; pfam02978 881621005356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621005357 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 881621005358 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 881621005359 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 881621005360 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 881621005361 P loop; other site 881621005362 GTP binding site [chemical binding]; other site 881621005363 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 881621005364 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 881621005365 Walker A/P-loop; other site 881621005366 ATP binding site [chemical binding]; other site 881621005367 Q-loop/lid; other site 881621005368 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 881621005369 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 881621005370 ABC transporter signature motif; other site 881621005371 Walker B; other site 881621005372 D-loop; other site 881621005373 H-loop/switch region; other site 881621005374 ribonuclease III; Reviewed; Region: rnc; PRK00102 881621005375 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 881621005376 dimerization interface [polypeptide binding]; other site 881621005377 active site 881621005378 metal binding site [ion binding]; metal-binding site 881621005379 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 881621005380 dsRNA binding site [nucleotide binding]; other site 881621005381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 881621005382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 881621005383 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 881621005384 NAD(P) binding site [chemical binding]; other site 881621005385 homotetramer interface [polypeptide binding]; other site 881621005386 homodimer interface [polypeptide binding]; other site 881621005387 active site 881621005388 Acyl transferase domain; Region: Acyl_transf_1; cl08282 881621005389 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 881621005390 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621005391 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 881621005392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 881621005393 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 881621005394 Y-family of DNA polymerases; Region: PolY; cl12025 881621005395 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 881621005396 generic binding surface II; other site 881621005397 ssDNA binding site; other site 881621005398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005399 ATP binding site [chemical binding]; other site 881621005400 putative Mg++ binding site [ion binding]; other site 881621005401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005402 nucleotide binding region [chemical binding]; other site 881621005403 ATP-binding site [chemical binding]; other site 881621005404 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 881621005405 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 881621005406 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 881621005407 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 881621005408 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 881621005409 putative L-serine binding site [chemical binding]; other site 881621005410 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 881621005411 DAK2 domain; Region: Dak2; cl03685 881621005412 Protein of unknown function (DUF322); Region: DUF322; cl00574 881621005413 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 881621005414 Thiamine pyrophosphokinase; Region: TPK; cd07995 881621005415 active site 881621005416 dimerization interface [polypeptide binding]; other site 881621005417 thiamine binding site [chemical binding]; other site 881621005418 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621005419 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 881621005420 substrate binding site [chemical binding]; other site 881621005421 hexamer interface [polypeptide binding]; other site 881621005422 metal binding site [ion binding]; metal-binding site 881621005423 GTPase RsgA; Reviewed; Region: PRK00098 881621005424 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 881621005425 GTPase/OB domain interface [polypeptide binding]; other site 881621005426 GTPase/Zn-binding domain interface [polypeptide binding]; other site 881621005427 GTP/Mg2+ binding site [chemical binding]; other site 881621005428 G4 box; other site 881621005429 G5 box; other site 881621005430 G1 box; other site 881621005431 Switch I region; other site 881621005432 G2 box; other site 881621005433 G3 box; other site 881621005434 Switch II region; other site 881621005435 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 881621005436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 881621005437 active site 881621005438 ATP binding site [chemical binding]; other site 881621005439 substrate binding site [chemical binding]; other site 881621005440 activation loop (A-loop); other site 881621005441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 881621005442 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 881621005443 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 881621005444 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 881621005445 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 881621005446 Protein phosphatase 2C; Region: PP2C; pfam00481 881621005447 Active site [active] 881621005448 16S rRNA methyltransferase B; Provisional; Region: PRK14902 881621005449 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 881621005450 putative RNA binding site [nucleotide binding]; other site 881621005451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621005452 S-adenosylmethionine binding site [chemical binding]; other site 881621005453 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 881621005454 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 881621005455 putative active site [active] 881621005456 substrate binding site [chemical binding]; other site 881621005457 putative cosubstrate binding site; other site 881621005458 catalytic site [active] 881621005459 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 881621005460 substrate binding site [chemical binding]; other site 881621005461 primosome assembly protein PriA; Validated; Region: PRK05580 881621005462 primosome assembly protein PriA; Validated; Region: PRK05580 881621005463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005464 ATP binding site [chemical binding]; other site 881621005465 putative Mg++ binding site [ion binding]; other site 881621005466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005467 ATP-binding site [chemical binding]; other site 881621005468 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 881621005469 Flavoprotein; Region: Flavoprotein; cl08021 881621005470 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 881621005471 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 881621005472 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 881621005473 catalytic site [active] 881621005474 G-X2-G-X-G-K; other site 881621005475 hypothetical protein; Provisional; Region: PRK11820 881621005476 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 881621005477 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 881621005478 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 881621005479 Domain of unknown function (DUF814); Region: DUF814; pfam05670 881621005480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005481 NAD(P) binding site [chemical binding]; other site 881621005482 active site 881621005483 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621005484 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 881621005485 active site 881621005486 dimer interface [polypeptide binding]; other site 881621005487 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 881621005488 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 881621005489 heterodimer interface [polypeptide binding]; other site 881621005490 active site 881621005491 FMN binding site [chemical binding]; other site 881621005492 homodimer interface [polypeptide binding]; other site 881621005493 substrate binding site [chemical binding]; other site 881621005494 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 881621005495 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 881621005496 FAD binding pocket [chemical binding]; other site 881621005497 FAD binding motif [chemical binding]; other site 881621005498 phosphate binding motif [ion binding]; other site 881621005499 beta-alpha-beta structure motif; other site 881621005500 NAD binding pocket [chemical binding]; other site 881621005501 Iron coordination center [ion binding]; other site 881621005502 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 881621005503 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005504 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621005505 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 881621005506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 881621005507 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621005508 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 881621005509 IMP binding site; other site 881621005510 dimer interface [polypeptide binding]; other site 881621005511 interdomain contacts; other site 881621005512 partial ornithine binding site; other site 881621005513 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 881621005514 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 881621005515 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 881621005516 catalytic site [active] 881621005517 subunit interface [polypeptide binding]; other site 881621005518 dihydroorotase; Validated; Region: pyrC; PRK09357 881621005519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 881621005520 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 881621005521 active site 881621005522 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 881621005523 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 881621005524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005525 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621005526 Permease family; Region: Xan_ur_permease; pfam00860 881621005527 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621005528 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 881621005529 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 881621005530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621005531 RNA binding surface [nucleotide binding]; other site 881621005532 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 881621005533 active site 881621005534 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 881621005535 lipoprotein signal peptidase; Provisional; Region: PRK14787 881621005536 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621005537 Permease family; Region: Xan_ur_permease; pfam00860 881621005538 multidrug efflux protein; Reviewed; Region: PRK01766 881621005539 MatE; Region: MatE; cl10513 881621005540 MatE; Region: MatE; cl10513 881621005541 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 881621005542 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 881621005543 metal binding site [ion binding]; metal-binding site 881621005544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621005545 ABC-ATPase subunit interface; other site 881621005546 dimer interface [polypeptide binding]; other site 881621005547 putative PBP binding regions; other site 881621005548 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 881621005549 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 881621005550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005551 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 881621005552 C-terminal peptidase (prc); Region: prc; TIGR00225 881621005553 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 881621005554 protein binding site [polypeptide binding]; other site 881621005555 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 881621005556 Catalytic dyad [active] 881621005557 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 881621005558 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005559 metal-binding site [ion binding] 881621005560 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 881621005561 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 881621005562 metal-binding site [ion binding] 881621005563 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621005564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621005565 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 881621005566 putative homotetramer interface [polypeptide binding]; other site 881621005567 putative homodimer interface [polypeptide binding]; other site 881621005568 putative allosteric switch controlling residues; other site 881621005569 putative metal binding site [ion binding]; other site 881621005570 putative homodimer-homodimer interface [polypeptide binding]; other site 881621005571 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 881621005572 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 881621005573 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621005574 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 881621005575 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 881621005576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005578 SelR domain; Region: SelR; cl00369 881621005579 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 881621005580 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 881621005581 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 881621005582 active site 881621005583 catalytic triad [active] 881621005584 oxyanion hole [active] 881621005585 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 881621005586 Haemolysin-III related; Region: HlyIII; cl03831 881621005587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005588 FOG: CBS domain [General function prediction only]; Region: COG0517 881621005589 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617 881621005590 Domain of unknown function (DUF299); Region: DUF299; cl00780 881621005591 pyruvate phosphate dikinase; Provisional; Region: PRK09279 881621005592 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 881621005593 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 881621005594 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 881621005595 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 881621005596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 881621005597 Predicted membrane protein [Function unknown]; Region: COG4129 881621005598 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 881621005599 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 881621005600 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 881621005601 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 881621005602 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 881621005603 Clostridial hydrophobic W; Region: ChW; cl02763 881621005604 Clostridial hydrophobic W; Region: ChW; cl02763 881621005605 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 881621005606 active site 881621005607 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 881621005608 substrate binding site [chemical binding]; other site 881621005609 metal binding site [ion binding]; metal-binding site 881621005610 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 881621005611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621005612 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 881621005613 folate binding site [chemical binding]; other site 881621005614 NADP+ binding site [chemical binding]; other site 881621005615 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 881621005616 dimerization interface [polypeptide binding]; other site 881621005617 active site 881621005618 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621005619 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621005620 Walker A/P-loop; other site 881621005621 ATP binding site [chemical binding]; other site 881621005622 Q-loop/lid; other site 881621005623 ABC transporter signature motif; other site 881621005624 Walker B; other site 881621005625 D-loop; other site 881621005626 H-loop/switch region; other site 881621005627 ABC transporter; Region: ABC_tran_2; pfam12848 881621005628 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621005629 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 881621005630 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 881621005631 Potassium binding sites [ion binding]; other site 881621005632 Cesium cation binding sites [ion binding]; other site 881621005633 manganese transport transcriptional regulator; Provisional; Region: PRK03902 881621005634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005635 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 881621005636 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 881621005637 DNA-binding site [nucleotide binding]; DNA binding site 881621005638 RNA-binding motif; other site 881621005639 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 881621005640 RNA/DNA hybrid binding site [nucleotide binding]; other site 881621005641 active site 881621005642 5'-3' exonuclease; Region: 53EXOc; smart00475 881621005643 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 881621005644 active site 881621005645 metal binding site 1 [ion binding]; metal-binding site 881621005646 putative 5' ssDNA interaction site; other site 881621005647 metal binding site 3; metal-binding site 881621005648 metal binding site 2 [ion binding]; metal-binding site 881621005649 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 881621005650 putative DNA binding site [nucleotide binding]; other site 881621005651 putative metal binding site [ion binding]; other site 881621005652 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 881621005653 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 881621005654 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 881621005655 putative active site [active] 881621005656 Permease family; Region: Xan_ur_permease; pfam00860 881621005657 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621005658 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621005659 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 881621005660 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 881621005661 active site 881621005662 Zn binding site [ion binding]; other site 881621005663 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 881621005664 THUMP domain; Region: THUMP; cl12076 881621005665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621005666 cell division protein GpsB; Provisional; Region: PRK14127 881621005667 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621005668 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 881621005669 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 881621005670 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 881621005671 Recombination protein U; Region: RecU; cl01314 881621005672 Transglycosylase; Region: Transgly; cl07896 881621005673 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621005674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 881621005675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621005676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621005678 dimerization interface [polypeptide binding]; other site 881621005679 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 881621005680 dimer interface [polypeptide binding]; other site 881621005681 FMN binding site [chemical binding]; other site 881621005682 NADPH bind site [chemical binding]; other site 881621005683 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 881621005684 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 881621005685 minor groove reading motif; other site 881621005686 helix-hairpin-helix signature motif; other site 881621005687 substrate binding pocket [chemical binding]; other site 881621005688 active site 881621005689 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 881621005690 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 881621005691 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 881621005692 similar to unknown protein, C-terminal part 881621005693 similar to unknown protein, N-terminal part 881621005694 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 881621005695 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 881621005696 putative dimer interface [polypeptide binding]; other site 881621005697 putative anticodon binding site; other site 881621005698 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 881621005699 homodimer interface [polypeptide binding]; other site 881621005700 motif 1; other site 881621005701 motif 2; other site 881621005702 active site 881621005703 motif 3; other site 881621005704 hypothetical protein; Validated; Region: PRK07682 881621005705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621005706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005707 homodimer interface [polypeptide binding]; other site 881621005708 catalytic residue [active] 881621005709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 881621005710 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 881621005711 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 881621005712 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 881621005713 active site 881621005714 substrate binding site [chemical binding]; other site 881621005715 catalytic site [active] 881621005716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621005717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621005718 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 881621005719 tetramerization interface [polypeptide binding]; other site 881621005720 active site 881621005721 pantoate--beta-alanine ligase; Region: panC; TIGR00018 881621005722 Pantoate-beta-alanine ligase; Region: PanC; cd00560 881621005723 active site 881621005724 ATP-binding site [chemical binding]; other site 881621005725 pantoate-binding site; other site 881621005726 HXXH motif; other site 881621005727 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 881621005728 active site 881621005729 oligomerization interface [polypeptide binding]; other site 881621005730 metal binding site [ion binding]; metal-binding site 881621005731 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621005732 catalytic residues [active] 881621005733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621005734 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 881621005735 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621005736 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 881621005737 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 881621005738 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 881621005739 active site 881621005740 NTP binding site [chemical binding]; other site 881621005741 metal binding triad [ion binding]; metal-binding site 881621005742 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 881621005743 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 881621005744 active site 881621005745 dimer interfaces [polypeptide binding]; other site 881621005746 catalytic residues [active] 881621005747 dihydrodipicolinate reductase; Provisional; Region: PRK00048 881621005748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005749 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 881621005750 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621005751 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621005752 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621005753 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621005754 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621005755 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 881621005756 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 881621005757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621005758 metal binding site [ion binding]; metal-binding site 881621005759 active site 881621005760 I-site; other site 881621005761 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 881621005762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 881621005763 metal binding site [ion binding]; metal-binding site 881621005764 active site 881621005765 I-site; other site 881621005766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 881621005767 malate dehydrogenase; Provisional; Region: PRK13529 881621005768 Malic enzyme, N-terminal domain; Region: malic; pfam00390 881621005769 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 881621005770 NAD(P) binding site [chemical binding]; other site 881621005771 Beta-lactamase; Region: Beta-lactamase; cl01009 881621005772 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 881621005773 Pyruvate formate lyase 1; Region: PFL1; cd01678 881621005774 coenzyme A binding site [chemical binding]; other site 881621005775 active site 881621005776 catalytic residues [active] 881621005777 glycine loop; other site 881621005778 Predicted flavoproteins [General function prediction only]; Region: COG2081 881621005779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005780 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 881621005781 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 881621005782 hypothetical protein; Provisional; Region: PRK03636 881621005783 UPF0302 domain; Region: UPF0302; pfam08864 881621005784 IDEAL domain; Region: IDEAL; cl07452 881621005785 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 881621005786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621005787 binding surface 881621005788 TPR motif; other site 881621005789 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 881621005790 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 881621005791 hinge; other site 881621005792 active site 881621005793 prephenate dehydrogenase; Validated; Region: PRK06545 881621005794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005795 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 881621005796 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 881621005797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621005798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621005799 homodimer interface [polypeptide binding]; other site 881621005800 catalytic residue [active] 881621005801 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 881621005802 homotrimer interaction site [polypeptide binding]; other site 881621005803 active site 881621005804 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 881621005805 active site 881621005806 dimer interface [polypeptide binding]; other site 881621005807 metal binding site [ion binding]; metal-binding site 881621005808 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 881621005809 Tetramer interface [polypeptide binding]; other site 881621005810 Active site [active] 881621005811 FMN-binding site [chemical binding]; other site 881621005812 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 881621005813 active site 881621005814 multimer interface [polypeptide binding]; other site 881621005815 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621005816 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621005817 substrate binding pocket [chemical binding]; other site 881621005818 chain length determination region; other site 881621005819 substrate-Mg2+ binding site; other site 881621005820 catalytic residues [active] 881621005821 aspartate-rich region 1; other site 881621005822 active site lid residues [active] 881621005823 aspartate-rich region 2; other site 881621005824 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 881621005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621005826 S-adenosylmethionine binding site [chemical binding]; other site 881621005827 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 881621005828 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 881621005829 homodecamer interface [polypeptide binding]; other site 881621005830 GTP cyclohydrolase I; Provisional; Region: PLN03044 881621005831 active site 881621005832 putative catalytic site residues [active] 881621005833 zinc binding site [ion binding]; other site 881621005834 GTP-CH-I/GFRP interaction surface; other site 881621005835 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 881621005836 IHF dimer interface [polypeptide binding]; other site 881621005837 IHF - DNA interface [nucleotide binding]; other site 881621005838 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 881621005839 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 881621005840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005841 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 881621005842 GTP-binding protein Der; Reviewed; Region: PRK00093 881621005843 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 881621005844 G1 box; other site 881621005845 GTP/Mg2+ binding site [chemical binding]; other site 881621005846 Switch I region; other site 881621005847 G2 box; other site 881621005848 Switch II region; other site 881621005849 G3 box; other site 881621005850 G4 box; other site 881621005851 G5 box; other site 881621005852 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 881621005853 G1 box; other site 881621005854 GTP/Mg2+ binding site [chemical binding]; other site 881621005855 Switch I region; other site 881621005856 G2 box; other site 881621005857 G3 box; other site 881621005858 Switch II region; other site 881621005859 G4 box; other site 881621005860 G5 box; other site 881621005861 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 881621005862 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 881621005863 RNA binding site [nucleotide binding]; other site 881621005864 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 881621005865 RNA binding site [nucleotide binding]; other site 881621005866 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 881621005867 RNA binding site [nucleotide binding]; other site 881621005868 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621005869 RNA binding site [nucleotide binding]; other site 881621005870 cytidylate kinase; Provisional; Region: cmk; PRK00023 881621005871 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 881621005872 CMP-binding site; other site 881621005873 The sites determining sugar specificity; other site 881621005874 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 881621005875 active site 881621005876 homotetramer interface [polypeptide binding]; other site 881621005877 homodimer interface [polypeptide binding]; other site 881621005878 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 881621005879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621005880 ATP binding site [chemical binding]; other site 881621005881 putative Mg++ binding site [ion binding]; other site 881621005882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621005883 nucleotide binding region [chemical binding]; other site 881621005884 ATP-binding site [chemical binding]; other site 881621005885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 881621005886 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 881621005887 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 881621005888 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 881621005889 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 881621005890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 881621005891 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 881621005892 dimerization interface [polypeptide binding]; other site 881621005893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621005894 dimer interface [polypeptide binding]; other site 881621005895 phosphorylation site [posttranslational modification] 881621005896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621005897 ATP binding site [chemical binding]; other site 881621005898 Mg2+ binding site [ion binding]; other site 881621005899 G-X-G motif; other site 881621005900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621005901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621005902 active site 881621005903 phosphorylation site [posttranslational modification] 881621005904 intermolecular recognition site; other site 881621005905 dimerization interface [polypeptide binding]; other site 881621005906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621005907 DNA binding site [nucleotide binding] 881621005908 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621005909 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621005910 RNA binding surface [nucleotide binding]; other site 881621005911 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 881621005912 active site 881621005913 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 881621005914 ScpA/B protein; Region: ScpA_ScpB; cl00598 881621005915 diaminopimelate decarboxylase; Region: lysA; TIGR01048 881621005916 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 881621005917 active site 881621005918 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621005919 substrate binding site [chemical binding]; other site 881621005920 catalytic residues [active] 881621005921 dimer interface [polypeptide binding]; other site 881621005922 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621005923 Sulfatase; Region: Sulfatase; cl10460 881621005924 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 881621005925 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 881621005926 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 881621005927 Int/Topo IB signature motif; other site 881621005928 active site 881621005929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 881621005930 metal binding site 2 [ion binding]; metal-binding site 881621005931 putative DNA binding helix; other site 881621005932 metal binding site 1 [ion binding]; metal-binding site 881621005933 dimer interface [polypeptide binding]; other site 881621005934 structural Zn2+ binding site [ion binding]; other site 881621005935 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 881621005936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621005937 ABC-ATPase subunit interface; other site 881621005938 dimer interface [polypeptide binding]; other site 881621005939 putative PBP binding regions; other site 881621005940 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621005941 ABC-ATPase subunit interface; other site 881621005942 dimer interface [polypeptide binding]; other site 881621005943 putative PBP binding regions; other site 881621005944 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621005945 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: FeuA; cd01138 881621005946 putative ligand binding residues [chemical binding]; other site 881621005947 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621005948 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621005949 Walker A/P-loop; other site 881621005950 ATP binding site [chemical binding]; other site 881621005951 Q-loop/lid; other site 881621005952 ABC transporter signature motif; other site 881621005953 Walker B; other site 881621005954 D-loop; other site 881621005955 H-loop/switch region; other site 881621005956 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621005957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621005959 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 881621005960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621005961 C-terminal domain; Region: RGG_Cterm; TIGR01716 881621005962 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 881621005963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621005964 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 881621005965 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621005966 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621005967 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621005968 Walker A/P-loop; other site 881621005969 ATP binding site [chemical binding]; other site 881621005970 Q-loop/lid; other site 881621005971 ABC transporter signature motif; other site 881621005972 Walker B; other site 881621005973 D-loop; other site 881621005974 H-loop/switch region; other site 881621005975 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 881621005976 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 881621005977 dimer interface [polypeptide binding]; other site 881621005978 ADP-ribose binding site [chemical binding]; other site 881621005979 active site 881621005980 nudix motif; other site 881621005981 metal binding site [ion binding]; metal-binding site 881621005982 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 881621005983 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 881621005984 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 881621005985 active site 881621005986 DNA polymerase IV; Validated; Region: PRK02406 881621005987 DNA binding site [nucleotide binding] 881621005988 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 881621005989 similar to transport protein, C-terminal part 881621005990 similar to transport protein, N-terminal part 881621005991 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621005992 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621005993 metal binding site [ion binding]; metal-binding site 881621005994 dimer interface [polypeptide binding]; other site 881621005995 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 881621005996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 881621005997 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 881621005998 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 881621005999 metal binding site [ion binding]; metal-binding site 881621006000 dimer interface [polypeptide binding]; other site 881621006001 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 881621006002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006003 NAD(P) binding site [chemical binding]; other site 881621006004 active site 881621006005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006006 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 881621006007 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 881621006008 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 881621006009 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 881621006010 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621006011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621006012 Dehydratase family; Region: ILVD_EDD; cl00340 881621006013 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 881621006014 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 881621006015 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006016 PYR/PP interface [polypeptide binding]; other site 881621006017 dimer interface [polypeptide binding]; other site 881621006018 TPP binding site [chemical binding]; other site 881621006019 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621006020 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 881621006021 TPP-binding site [chemical binding]; other site 881621006022 dimer interface [polypeptide binding]; other site 881621006023 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 881621006024 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 881621006025 putative valine binding site [chemical binding]; other site 881621006026 dimer interface [polypeptide binding]; other site 881621006027 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 881621006028 ketol-acid reductoisomerase; Provisional; Region: PRK05479 881621006029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006030 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 881621006031 2-isopropylmalate synthase; Validated; Region: PRK00915 881621006032 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 881621006033 active site 881621006034 catalytic residues [active] 881621006035 metal binding site [ion binding]; metal-binding site 881621006036 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 881621006037 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 881621006038 isocitrate dehydrogenase; Validated; Region: PRK06451 881621006039 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 881621006040 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 881621006041 substrate binding site [chemical binding]; other site 881621006042 ligand binding site [chemical binding]; other site 881621006043 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 881621006044 substrate binding site [chemical binding]; other site 881621006045 threonine dehydratase; Validated; Region: PRK08639 881621006046 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 881621006047 tetramer interface [polypeptide binding]; other site 881621006048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006049 catalytic residue [active] 881621006050 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 881621006051 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 881621006052 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 881621006053 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 881621006054 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 881621006055 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 881621006056 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006057 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006058 DNA binding site [nucleotide binding] 881621006059 domain linker motif; other site 881621006060 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006061 dimerization interface [polypeptide binding]; other site 881621006062 ligand binding site [chemical binding]; other site 881621006063 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 881621006064 intersubunit interface [polypeptide binding]; other site 881621006065 active site 881621006066 catalytic residue [active] 881621006067 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621006068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006069 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621006070 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 881621006071 active pocket/dimerization site; other site 881621006072 active site 881621006073 phosphorylation site [posttranslational modification] 881621006074 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006075 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 881621006076 putative active site [active] 881621006077 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 881621006078 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 881621006079 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 881621006080 dimer interface [polypeptide binding]; other site 881621006081 active site 881621006082 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 881621006083 dimer interface [polypeptide binding]; other site 881621006084 active site 881621006085 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 881621006086 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 881621006087 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 881621006088 active site 881621006089 phosphorylation site [posttranslational modification] 881621006090 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006092 DNA-binding site [nucleotide binding]; DNA binding site 881621006093 UTRA domain; Region: UTRA; cl01230 881621006094 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621006095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006096 DNA-binding site [nucleotide binding]; DNA binding site 881621006097 UTRA domain; Region: UTRA; cl01230 881621006098 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621006099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621006100 active site 881621006101 catalytic tetrad [active] 881621006102 acetolactate synthase; Reviewed; Region: PRK08617 881621006103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 881621006104 PYR/PP interface [polypeptide binding]; other site 881621006105 dimer interface [polypeptide binding]; other site 881621006106 TPP binding site [chemical binding]; other site 881621006107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 881621006108 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 881621006109 TPP-binding site [chemical binding]; other site 881621006110 dimer interface [polypeptide binding]; other site 881621006111 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006112 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 881621006113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 881621006114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006115 putative PBP binding loops; other site 881621006116 dimer interface [polypeptide binding]; other site 881621006117 ABC-ATPase subunit interface; other site 881621006118 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 881621006119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006120 dimer interface [polypeptide binding]; other site 881621006121 conserved gate region; other site 881621006122 ABC-ATPase subunit interface; other site 881621006123 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 881621006124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621006125 active site 881621006126 phosphorylation site [posttranslational modification] 881621006127 intermolecular recognition site; other site 881621006128 dimerization interface [polypeptide binding]; other site 881621006129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006130 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 881621006131 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 881621006132 Histidine kinase; Region: His_kinase; pfam06580 881621006133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621006134 ATP binding site [chemical binding]; other site 881621006135 Mg2+ binding site [ion binding]; other site 881621006136 G-X-G motif; other site 881621006137 Protein of unknown function, DUF624; Region: DUF624; cl02369 881621006138 Uncharacterized conserved protein [Function unknown]; Region: COG3538 881621006139 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 881621006140 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006141 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621006142 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 881621006143 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 881621006144 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 881621006145 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 881621006146 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 881621006147 DNA-binding site [nucleotide binding]; DNA binding site 881621006148 RNA-binding motif; other site 881621006149 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 881621006150 active site 881621006151 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 881621006152 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 881621006153 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 881621006154 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 881621006155 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006156 HIGH motif; other site 881621006157 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 881621006158 active site 881621006159 KMSKS motif; other site 881621006160 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 881621006161 tRNA binding surface [nucleotide binding]; other site 881621006162 anticodon binding site; other site 881621006163 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 881621006164 DivIVA protein; Region: DivIVA; pfam05103 881621006165 DivIVA domain; Region: DivI1A_domain; TIGR03544 881621006166 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 881621006167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006168 3H domain; Region: 3H; pfam02829 881621006169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621006170 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 881621006171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621006172 catalytic residue [active] 881621006173 L-aspartate oxidase; Provisional; Region: PRK08071 881621006174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006175 domain; Region: Succ_DH_flav_C; pfam02910 881621006176 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 881621006177 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 881621006178 dimerization interface [polypeptide binding]; other site 881621006179 active site 881621006180 Quinolinate synthetase A protein; Region: NadA; cl00420 881621006181 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 881621006182 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006183 RNA binding surface [nucleotide binding]; other site 881621006184 YGGT family; Region: YGGT; cl00508 881621006185 Protein of unknown function (DUF552); Region: DUF552; cl00775 881621006186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 881621006187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 881621006188 catalytic residue [active] 881621006189 cell division protein FtsZ; Validated; Region: PRK09330 881621006190 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 881621006191 nucleotide binding site [chemical binding]; other site 881621006192 SulA interaction site; other site 881621006193 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 881621006194 Cell division protein FtsA; Region: FtsA; cl11496 881621006195 Cell division protein FtsA; Region: FtsA; cl11496 881621006196 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 881621006197 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 881621006198 Cell division protein FtsQ; Region: FtsQ; pfam03799 881621006199 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 881621006200 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 881621006201 active site 881621006202 homodimer interface [polypeptide binding]; other site 881621006203 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 881621006204 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006206 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 881621006207 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 881621006208 Mg++ binding site [ion binding]; other site 881621006209 putative catalytic motif [active] 881621006210 putative substrate binding site [chemical binding]; other site 881621006211 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 881621006212 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 881621006213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 881621006214 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 881621006215 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 881621006216 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 881621006217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 881621006218 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 881621006219 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 881621006220 Septum formation initiator; Region: DivIC; cl11433 881621006221 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 881621006222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 881621006223 cell division protein MraZ; Reviewed; Region: PRK00326 881621006224 MraZ protein; Region: MraZ; pfam02381 881621006225 MraZ protein; Region: MraZ; pfam02381 881621006226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006228 putative substrate translocation pore; other site 881621006229 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 881621006230 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 881621006231 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 881621006232 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 881621006233 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 881621006234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006235 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 881621006236 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 881621006237 hypothetical protein; Provisional; Region: PRK13670 881621006238 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 881621006239 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621006240 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621006241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621006242 Walker A/P-loop; other site 881621006243 ATP binding site [chemical binding]; other site 881621006244 Q-loop/lid; other site 881621006245 ABC transporter signature motif; other site 881621006246 Walker B; other site 881621006247 D-loop; other site 881621006248 H-loop/switch region; other site 881621006249 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 881621006250 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 881621006251 protein binding site [polypeptide binding]; other site 881621006252 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 881621006253 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 881621006254 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 881621006255 active site 881621006256 (T/H)XGH motif; other site 881621006257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621006258 S-adenosylmethionine binding site [chemical binding]; other site 881621006259 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 881621006260 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621006261 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 881621006262 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 881621006263 UbiA prenyltransferase family; Region: UbiA; cl00337 881621006264 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 881621006265 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 881621006266 Ion transport protein; Region: Ion_trans; pfam00520 881621006267 Ion channel; Region: Ion_trans_2; cl11596 881621006268 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 881621006269 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006270 SCP-2 sterol transfer family; Region: SCP2; cl01225 881621006271 similar to Peptide methionine sulfoxide reductase MsrB internal part 881621006272 similar to Peptide methionine sulfoxide reductase MsrB C-terminal part 881621006273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 881621006274 MOSC domain; Region: MOSC; pfam03473 881621006275 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 881621006276 Copper resistance protein CopC; Region: CopC; cl01012 881621006277 Copper resistance protein D; Region: CopD; cl00563 881621006278 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 881621006279 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 881621006280 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-...; Region: Ntn_PVA; cd00542 881621006281 active site 881621006282 similar to soluble internalin, partial 881621006283 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621006284 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621006285 LRR adjacent; Region: LRR_adjacent; pfam08191 881621006286 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621006287 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 881621006288 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 881621006289 ring oligomerisation interface [polypeptide binding]; other site 881621006290 ATP/Mg binding site [chemical binding]; other site 881621006291 stacking interactions; other site 881621006292 hinge regions; other site 881621006293 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 881621006294 oligomerisation interface [polypeptide binding]; other site 881621006295 mobile loop; other site 881621006296 roof hairpin; other site 881621006297 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 881621006298 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 881621006299 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 881621006300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006301 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 881621006302 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621006303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621006304 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621006305 ABC transporter; Region: ABC_tran_2; pfam12848 881621006306 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 881621006307 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621006308 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 881621006309 UGMP family protein; Validated; Region: PRK09604 881621006310 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 881621006311 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 881621006312 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 881621006313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006314 Coenzyme A binding pocket [chemical binding]; other site 881621006315 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 881621006316 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 881621006317 CrcB-like protein; Region: CRCB; cl09114 881621006318 CrcB-like protein; Region: CRCB; cl09114 881621006319 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 881621006320 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 881621006321 active site 881621006322 substrate binding site [chemical binding]; other site 881621006323 ATP binding site [chemical binding]; other site 881621006324 Putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621006325 putative peptidoglycan bound protein (LPXTG motif),N-terminal part 881621006326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621006327 non-specific DNA binding site [nucleotide binding]; other site 881621006328 salt bridge; other site 881621006329 sequence-specific DNA binding site [nucleotide binding]; other site 881621006330 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 881621006331 MatE; Region: MatE; cl10513 881621006332 MatE; Region: MatE; cl10513 881621006333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621006334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621006335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621006336 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 881621006337 substrate binding pocket [chemical binding]; other site 881621006338 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 881621006339 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 881621006340 ANP binding site [chemical binding]; other site 881621006341 Substrate Binding Site II [chemical binding]; other site 881621006342 Substrate Binding Site I [chemical binding]; other site 881621006343 argininosuccinate lyase; Provisional; Region: PRK00855 881621006344 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 881621006345 active sites [active] 881621006346 tetramer interface [polypeptide binding]; other site 881621006347 BCCT family transporter; Region: BCCT; cl00569 881621006348 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 881621006349 active site 881621006350 intersubunit interface [polypeptide binding]; other site 881621006351 Zn2+ binding site [ion binding]; other site 881621006352 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621006353 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621006354 putative substrate binding site [chemical binding]; other site 881621006355 putative ATP binding site [chemical binding]; other site 881621006356 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621006357 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621006358 P-loop; other site 881621006359 active site 881621006360 phosphorylation site [posttranslational modification] 881621006361 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006362 active site 881621006363 phosphorylation site [posttranslational modification] 881621006364 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621006365 PRD domain; Region: PRD; pfam00874 881621006366 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006367 P-loop; other site 881621006368 active site 881621006369 phosphorylation site [posttranslational modification] 881621006370 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 881621006371 active site 881621006372 phosphorylation site [posttranslational modification] 881621006373 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 881621006374 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 881621006375 Gram-positive; Region: pullulan_Gpos; TIGR02102 881621006376 similar to internalin, peptidoglycan bound protein (LPxTG motif, partial 881621006377 similar to unknown proteins, N-terminal part 881621006378 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 881621006379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006380 DNA-binding site [nucleotide binding]; DNA binding site 881621006381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006383 homodimer interface [polypeptide binding]; other site 881621006384 catalytic residue [active] 881621006385 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 881621006386 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 881621006387 active site 881621006388 multimer interface [polypeptide binding]; other site 881621006389 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 881621006390 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 881621006391 predicted active site [active] 881621006392 catalytic triad [active] 881621006393 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 881621006394 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 881621006395 FeoA domain; Region: FeoA; cl00838 881621006396 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 881621006397 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 881621006398 G1 box; other site 881621006399 GTP/Mg2+ binding site [chemical binding]; other site 881621006400 Switch I region; other site 881621006401 G2 box; other site 881621006402 G3 box; other site 881621006403 Switch II region; other site 881621006404 G4 box; other site 881621006405 G5 box; other site 881621006406 Nucleoside recognition; Region: Gate; cl00486 881621006407 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 881621006408 Nucleoside recognition; Region: Gate; cl00486 881621006409 Similar to ABC transporter, ATP-binding protein. Truncated, C-terminal part 881621006410 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 881621006411 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 881621006412 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 881621006413 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 881621006414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 881621006415 putative active site [active] 881621006416 putative metal binding site [ion binding]; other site 881621006417 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 881621006418 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 881621006419 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 881621006420 dimer interface [polypeptide binding]; other site 881621006421 FMN binding site [chemical binding]; other site 881621006422 NADPH bind site [chemical binding]; other site 881621006423 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 881621006424 Chlorite dismutase; Region: Chlor_dismutase; cl01280 881621006425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621006426 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621006427 Walker A/P-loop; other site 881621006428 ATP binding site [chemical binding]; other site 881621006429 Q-loop/lid; other site 881621006430 ABC transporter signature motif; other site 881621006431 Walker B; other site 881621006432 D-loop; other site 881621006433 H-loop/switch region; other site 881621006434 FtsX-like permease family; Region: FtsX; pfam02687 881621006435 FtsX-like permease family; Region: FtsX; pfam02687 881621006436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006437 Coenzyme A binding pocket [chemical binding]; other site 881621006438 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 881621006439 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 881621006440 active site 881621006441 substrate binding site [chemical binding]; other site 881621006442 metal binding site [ion binding]; metal-binding site 881621006443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 881621006444 YbbR-like protein; Region: YbbR; pfam07949 881621006445 YbbR-like protein; Region: YbbR; pfam07949 881621006446 YbbR-like protein; Region: YbbR; pfam07949 881621006447 Uncharacterized conserved protein [Function unknown]; Region: COG1624 881621006448 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 881621006449 maltose phosphorylase; Provisional; Region: PRK13807 881621006450 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621006451 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621006452 Predicted integral membrane protein [Function unknown]; Region: COG5521 881621006453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006454 dimer interface [polypeptide binding]; other site 881621006455 conserved gate region; other site 881621006456 putative PBP binding loops; other site 881621006457 ABC-ATPase subunit interface; other site 881621006458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006459 dimer interface [polypeptide binding]; other site 881621006460 conserved gate region; other site 881621006461 putative PBP binding loops; other site 881621006462 ABC-ATPase subunit interface; other site 881621006463 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 881621006464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006465 maltodextrin glucosidase; Provisional; Region: PRK10785 881621006466 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 881621006467 homodimer; other site 881621006468 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621006469 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 881621006470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621006471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621006472 DNA binding site [nucleotide binding] 881621006473 domain linker motif; other site 881621006474 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621006475 ligand binding site [chemical binding]; other site 881621006476 dimerization interface [polypeptide binding]; other site 881621006477 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 881621006478 similar to other protein, C-terminal part 881621006479 similar to other protein, N-terminal part 881621006480 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621006481 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621006482 ligand binding site [chemical binding]; other site 881621006483 flexible hinge region; other site 881621006484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006485 hypothetical protein; Provisional; Region: PRK08185 881621006486 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 881621006487 intersubunit interface [polypeptide binding]; other site 881621006488 active site 881621006489 zinc binding site [ion binding]; other site 881621006490 Na+ binding site [ion binding]; other site 881621006491 hypothetical protein; Provisional; Region: PRK08185 881621006492 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 881621006493 intersubunit interface [polypeptide binding]; other site 881621006494 active site 881621006495 zinc binding site [ion binding]; other site 881621006496 Na+ binding site [ion binding]; other site 881621006497 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621006498 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 881621006499 P-loop; other site 881621006500 active site 881621006501 phosphorylation site [posttranslational modification] 881621006502 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006503 active site 881621006504 phosphorylation site [posttranslational modification] 881621006505 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621006506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006507 PRD domain; Region: PRD; pfam00874 881621006508 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621006509 P-loop; other site 881621006510 active site 881621006511 phosphorylation site [posttranslational modification] 881621006512 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 881621006513 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 881621006514 Walker A/P-loop; other site 881621006515 ATP binding site [chemical binding]; other site 881621006516 Q-loop/lid; other site 881621006517 ABC transporter signature motif; other site 881621006518 Walker B; other site 881621006519 D-loop; other site 881621006520 H-loop/switch region; other site 881621006521 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 881621006522 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 881621006523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006524 Coenzyme A binding pocket [chemical binding]; other site 881621006525 Transcriptional regulators [Transcription]; Region: GntR; COG1802 881621006526 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621006527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621006528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006529 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 881621006530 putative dimerization interface [polypeptide binding]; other site 881621006531 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 881621006532 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 881621006533 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621006534 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 881621006535 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621006536 catalytic residues [active] 881621006537 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 881621006538 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 881621006539 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 881621006540 dimer interface [polypeptide binding]; other site 881621006541 putative radical transfer pathway; other site 881621006542 diiron center [ion binding]; other site 881621006543 tyrosyl radical; other site 881621006544 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 881621006545 Class I ribonucleotide reductase; Region: RNR_I; cd01679 881621006546 active site 881621006547 dimer interface [polypeptide binding]; other site 881621006548 catalytic residues [active] 881621006549 effector binding site; other site 881621006550 R2 peptide binding site; other site 881621006551 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621006552 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621006553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006554 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 881621006555 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621006556 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 881621006557 DNA interaction; other site 881621006558 Metal-binding active site; metal-binding site 881621006559 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 881621006560 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 881621006561 conserved cys residue [active] 881621006562 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621006563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 881621006564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006565 Cupin domain; Region: Cupin_2; cl09118 881621006566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 881621006568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006569 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621006570 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 881621006571 ligand binding site [chemical binding]; other site 881621006572 flexible hinge region; other site 881621006573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 881621006574 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 881621006575 dimer interface [polypeptide binding]; other site 881621006576 active site 881621006577 metal binding site [ion binding]; metal-binding site 881621006578 glutathione binding site [chemical binding]; other site 881621006579 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 881621006580 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 881621006581 FMN binding site [chemical binding]; other site 881621006582 substrate binding site [chemical binding]; other site 881621006583 putative catalytic residue [active] 881621006584 similar to antiporter proteins, C-terminal part 881621006585 similar to antiporter proteins, N-terminal part 881621006586 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 881621006587 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006588 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006589 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 881621006590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621006591 Walker A motif; other site 881621006592 ATP binding site [chemical binding]; other site 881621006593 Walker B motif; other site 881621006594 arginine finger; other site 881621006595 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 881621006596 similar putative peptidoglycan linked protein (LPXTG motif), C-terminal part 881621006597 similar putative peptidoglycan linked protein (LPXTG motif), central part 881621006598 similar putative peptidoglycan linked protein (LPXTG motif), N-terminal part 881621006599 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621006600 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006601 Collagen binding domain; Region: Collagen_bind; pfam05737 881621006602 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006603 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006604 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006605 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006606 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006607 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 881621006608 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006609 Collagen binding domain; Region: Collagen_bind; pfam05737 881621006610 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006611 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006612 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621006613 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 881621006614 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 881621006615 active site 881621006616 catalytic site [active] 881621006617 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621006618 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621006619 Walker A/P-loop; other site 881621006620 ATP binding site [chemical binding]; other site 881621006621 Q-loop/lid; other site 881621006622 ABC transporter signature motif; other site 881621006623 Walker B; other site 881621006624 D-loop; other site 881621006625 H-loop/switch region; other site 881621006626 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621006627 ABC-ATPase subunit interface; other site 881621006628 dimer interface [polypeptide binding]; other site 881621006629 putative PBP binding regions; other site 881621006630 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 881621006631 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 881621006632 intersubunit interface [polypeptide binding]; other site 881621006633 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006634 heme-binding site [chemical binding]; other site 881621006635 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 881621006636 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006637 heme-binding site [chemical binding]; other site 881621006638 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006639 heme-binding site [chemical binding]; other site 881621006640 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621006641 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 881621006642 heme-binding site [chemical binding]; other site 881621006643 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 881621006644 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621006645 oligoendopeptidase F; Region: pepF; TIGR00181 881621006646 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 881621006647 active site 881621006648 Zn binding site [ion binding]; other site 881621006649 Competence protein CoiA-like family; Region: CoiA; cl11541 881621006650 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 881621006651 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 881621006652 putative catalytic residues [active] 881621006653 thiol/disulfide switch; other site 881621006654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 881621006655 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 881621006656 Walker A/P-loop; other site 881621006657 ATP binding site [chemical binding]; other site 881621006658 Q-loop/lid; other site 881621006659 ABC transporter signature motif; other site 881621006660 Walker B; other site 881621006661 D-loop; other site 881621006662 H-loop/switch region; other site 881621006663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621006664 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 881621006665 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 881621006666 Walker A/P-loop; other site 881621006667 ATP binding site [chemical binding]; other site 881621006668 Q-loop/lid; other site 881621006669 ABC transporter signature motif; other site 881621006670 Walker B; other site 881621006671 D-loop; other site 881621006672 H-loop/switch region; other site 881621006673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 881621006674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006675 dimer interface [polypeptide binding]; other site 881621006676 conserved gate region; other site 881621006677 putative PBP binding loops; other site 881621006678 ABC-ATPase subunit interface; other site 881621006679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 881621006680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006681 dimer interface [polypeptide binding]; other site 881621006682 conserved gate region; other site 881621006683 putative PBP binding loops; other site 881621006684 ABC-ATPase subunit interface; other site 881621006685 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621006686 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621006687 peptide binding site [polypeptide binding]; other site 881621006688 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 881621006689 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 881621006690 active site 881621006691 HIGH motif; other site 881621006692 dimer interface [polypeptide binding]; other site 881621006693 KMSKS motif; other site 881621006694 OsmC-like protein; Region: OsmC; cl00767 881621006695 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621006696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006697 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 881621006698 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 881621006699 dimer interface [polypeptide binding]; other site 881621006700 active site 881621006701 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 881621006702 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 881621006703 dimer interface [polypeptide binding]; other site 881621006704 active site 881621006705 CoA binding pocket [chemical binding]; other site 881621006706 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 881621006707 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 881621006708 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 881621006709 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621006710 catalytic core [active] 881621006711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 881621006712 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 881621006713 Clp amino terminal domain; Region: Clp_N; pfam02861 881621006714 Clp amino terminal domain; Region: Clp_N; pfam02861 881621006715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621006716 Walker A motif; other site 881621006717 ATP binding site [chemical binding]; other site 881621006718 Walker B motif; other site 881621006719 arginine finger; other site 881621006720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621006721 Walker A motif; other site 881621006722 ATP binding site [chemical binding]; other site 881621006723 Walker B motif; other site 881621006724 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 881621006725 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 881621006726 similar to unknown protein, C-terminal part 881621006727 similar to unknown protein, N-terminal part 881621006728 Predicted acetyltransferase [General function prediction only]; Region: COG3393 881621006729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621006730 ferrochelatase; Provisional; Region: PRK12435 881621006731 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 881621006732 C-terminal domain interface [polypeptide binding]; other site 881621006733 active site 881621006734 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 881621006735 active site 881621006736 N-terminal domain interface [polypeptide binding]; other site 881621006737 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 881621006738 substrate binding site [chemical binding]; other site 881621006739 active site 881621006740 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621006741 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 881621006742 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621006743 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621006744 Walker A/P-loop; other site 881621006745 ATP binding site [chemical binding]; other site 881621006746 Q-loop/lid; other site 881621006747 ABC transporter signature motif; other site 881621006748 Walker B; other site 881621006749 D-loop; other site 881621006750 H-loop/switch region; other site 881621006751 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 881621006752 HIT family signature motif; other site 881621006753 catalytic residue [active] 881621006754 YtxH-like protein; Region: YtxH; cl02079 881621006755 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 881621006756 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 881621006757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621006758 PPIC-type PPIASE domain; Region: Rotamase; cl08278 881621006759 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 881621006760 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 881621006761 generic binding surface II; other site 881621006762 generic binding surface I; other site 881621006763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621006764 Uncharacterized conserved protein [Function unknown]; Region: COG4717 881621006765 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 881621006766 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 881621006767 active site 881621006768 metal binding site [ion binding]; metal-binding site 881621006769 DNA binding site [nucleotide binding] 881621006770 Protein of unknown function (DUF964); Region: DUF964; cl01483 881621006771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 881621006772 fumarate hydratase; Reviewed; Region: fumC; PRK00485 881621006773 Class II fumarases; Region: Fumarase_classII; cd01362 881621006774 active site 881621006775 tetramer interface [polypeptide binding]; other site 881621006776 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 881621006777 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621006778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621006779 Walker A/P-loop; other site 881621006780 ATP binding site [chemical binding]; other site 881621006781 Q-loop/lid; other site 881621006782 ABC transporter signature motif; other site 881621006783 Walker B; other site 881621006784 D-loop; other site 881621006785 H-loop/switch region; other site 881621006786 Transglycosylase; Region: Transgly; cl07896 881621006787 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 881621006788 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 881621006789 Low molecular weight phosphatase family; Region: LMWPc; cl00105 881621006790 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621006791 Cation efflux family; Region: Cation_efflux; cl00316 881621006792 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621006793 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621006794 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621006795 Transporter associated domain; Region: CorC_HlyC; cl08393 881621006796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621006797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006798 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 881621006799 putative dimerization interface [polypeptide binding]; other site 881621006800 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 881621006801 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 881621006802 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 881621006803 active site 881621006804 FMN binding site [chemical binding]; other site 881621006805 substrate binding site [chemical binding]; other site 881621006806 putative catalytic residue [active] 881621006807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621006808 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 881621006809 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 881621006810 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 881621006811 shikimate binding site; other site 881621006812 NAD(P) binding site [chemical binding]; other site 881621006813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006815 putative substrate translocation pore; other site 881621006816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006818 putative substrate translocation pore; other site 881621006819 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 881621006820 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 881621006821 DNA binding site [nucleotide binding] 881621006822 active site 881621006823 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 881621006824 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 881621006825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 881621006827 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 881621006828 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 881621006829 active site 881621006830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 881621006831 putative dimer interface [polypeptide binding]; other site 881621006832 ligand binding site [chemical binding]; other site 881621006833 Zn binding site [ion binding]; other site 881621006834 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 881621006835 Active site [active] 881621006836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621006837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621006838 active site 881621006839 catalytic tetrad [active] 881621006840 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 881621006841 Phosphate transporter family; Region: PHO4; cl00396 881621006842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 881621006843 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 881621006844 substrate binding pocket [chemical binding]; other site 881621006845 membrane-bound complex binding site; other site 881621006846 hinge residues; other site 881621006847 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 881621006848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621006849 dimer interface [polypeptide binding]; other site 881621006850 conserved gate region; other site 881621006851 putative PBP binding loops; other site 881621006852 ABC-ATPase subunit interface; other site 881621006853 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 881621006854 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 881621006855 Walker A/P-loop; other site 881621006856 ATP binding site [chemical binding]; other site 881621006857 Q-loop/lid; other site 881621006858 ABC transporter signature motif; other site 881621006859 Walker B; other site 881621006860 D-loop; other site 881621006861 H-loop/switch region; other site 881621006862 hypothetical protein; Validated; Region: PRK07682 881621006863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006865 homodimer interface [polypeptide binding]; other site 881621006866 catalytic residue [active] 881621006867 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 881621006868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621006869 motif II; other site 881621006870 Sulfate transporter family; Region: Sulfate_transp; cl00967 881621006871 Permease family; Region: Xan_ur_permease; pfam00860 881621006872 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 881621006873 proposed catalytic triad [active] 881621006874 conserved cys residue [active] 881621006875 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621006876 methionine cluster; other site 881621006877 active site 881621006878 phosphorylation site [posttranslational modification] 881621006879 metal binding site [ion binding]; metal-binding site 881621006880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621006881 Coenzyme A binding pocket [chemical binding]; other site 881621006882 Domain of unknown function DUF59; Region: DUF59; cl00941 881621006883 esterase; Provisional; Region: PRK10566 881621006884 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621006885 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621006886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621006887 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621006888 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621006889 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621006890 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 881621006891 similar to unknown protein, C-terminal part 881621006892 Similar to unknown protein, N-terminal part 881621006893 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 881621006894 UvrD/REP helicase; Region: UvrD-helicase; cl14126 881621006895 UvrD/REP helicase; Region: UvrD-helicase; cl14126 881621006896 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621006897 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 881621006898 UvrD/REP helicase; Region: UvrD-helicase; cl14126 881621006899 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621006900 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 881621006901 IDEAL domain; Region: IDEAL; cl07452 881621006902 ComK protein; Region: ComK; cl11560 881621006903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621006904 non-specific DNA binding site [nucleotide binding]; other site 881621006905 salt bridge; other site 881621006906 sequence-specific DNA binding site [nucleotide binding]; other site 881621006907 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621006908 active site 881621006909 phosphorylation site [posttranslational modification] 881621006910 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 881621006911 P-loop; other site 881621006912 active site 881621006913 phosphorylation site [posttranslational modification] 881621006914 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621006915 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 881621006916 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 881621006917 putative substrate binding site [chemical binding]; other site 881621006918 putative ATP binding site [chemical binding]; other site 881621006919 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621006920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621006921 DNA-binding site [nucleotide binding]; DNA binding site 881621006922 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006923 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH...; Region: Peptidase_C1B; cd00585 881621006924 trimer interface [polypeptide binding]; other site 881621006925 active site 881621006926 G bulge; other site 881621006927 Protein of unknown function (DUF523); Region: DUF523; cl00733 881621006928 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 881621006929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006930 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 881621006931 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 881621006932 substrate binding site [chemical binding]; other site 881621006933 ATP binding site [chemical binding]; other site 881621006934 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 881621006935 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 881621006936 RNA binding surface [nucleotide binding]; other site 881621006937 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 881621006938 active site 881621006939 uracil binding [chemical binding]; other site 881621006940 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 881621006941 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 881621006942 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 881621006943 active site 881621006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621006945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621006946 putative substrate translocation pore; other site 881621006947 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 881621006948 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 881621006949 active site 881621006950 trimer interface [polypeptide binding]; other site 881621006951 allosteric site; other site 881621006952 active site lid [active] 881621006953 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621006954 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621006955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621006956 active site 881621006957 motif I; other site 881621006958 motif II; other site 881621006959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621006960 Predicted membrane protein [Function unknown]; Region: COG1511 881621006961 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 881621006962 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 881621006963 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 881621006964 ABC-2 type transporter; Region: ABC2_membrane; cl11417 881621006965 Predicted transcriptional regulator [Transcription]; Region: COG1959 881621006966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006967 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621006968 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 881621006969 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621006970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006971 catalytic residue [active] 881621006972 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 881621006973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006974 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 881621006975 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 881621006976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621006977 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 881621006978 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 881621006979 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 881621006980 active site 881621006981 dimer interface [polypeptide binding]; other site 881621006982 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 881621006983 dimer interface [polypeptide binding]; other site 881621006984 active site 881621006985 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 881621006986 nudix motif; other site 881621006987 general stress protein 13; Validated; Region: PRK08059 881621006988 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 881621006989 RNA binding site [nucleotide binding]; other site 881621006990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 881621006991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621006992 homodimer interface [polypeptide binding]; other site 881621006993 catalytic residue [active] 881621006994 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 881621006995 FtsX-like permease family; Region: FtsX; pfam02687 881621006996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 881621006997 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 881621006998 Walker A/P-loop; other site 881621006999 ATP binding site [chemical binding]; other site 881621007000 Q-loop/lid; other site 881621007001 ABC transporter signature motif; other site 881621007002 Walker B; other site 881621007003 D-loop; other site 881621007004 H-loop/switch region; other site 881621007005 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621007006 active site 881621007007 P-loop; other site 881621007008 phosphorylation site [posttranslational modification] 881621007009 similar to aspartate kinase, N-terminal part 881621007010 similar to aspartate kinase, central part 881621007011 similar to aspartate kinase, C-terminal part 881621007012 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 881621007013 active site 881621007014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007016 putative substrate translocation pore; other site 881621007017 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 881621007018 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 881621007019 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 881621007020 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 881621007021 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 881621007022 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 881621007023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 881621007024 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 881621007025 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 881621007026 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 881621007027 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 881621007028 CoenzymeA binding site [chemical binding]; other site 881621007029 subunit interaction site [polypeptide binding]; other site 881621007030 PHB binding site; other site 881621007031 Divergent PAP2 family; Region: DUF212; cl00855 881621007032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621007033 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621007034 active site 881621007035 catalytic tetrad [active] 881621007036 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 881621007037 Cl- selectivity filter; other site 881621007038 Cl- binding residues [ion binding]; other site 881621007039 pore gating glutamate residue; other site 881621007040 dimer interface [polypeptide binding]; other site 881621007041 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621007042 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 881621007043 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621007044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007045 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 881621007046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007048 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 881621007049 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 881621007050 NifU-like domain; Region: NifU; cl00484 881621007051 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 881621007052 Domain of unknown function DUF21; Region: DUF21; pfam01595 881621007053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 881621007054 Transporter associated domain; Region: CorC_HlyC; cl08393 881621007055 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621007056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007057 Coenzyme A binding pocket [chemical binding]; other site 881621007058 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 881621007059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621007060 active site 881621007061 motif I; other site 881621007062 motif II; other site 881621007063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621007064 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 881621007065 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 881621007066 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 881621007067 active site 881621007068 metal binding site [ion binding]; metal-binding site 881621007069 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 881621007070 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 881621007071 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 881621007072 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 881621007073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621007074 active site 881621007075 catalytic tetrad [active] 881621007076 Protein of unknown function DUF72; Region: DUF72; cl00777 881621007077 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 881621007078 FeS assembly protein SufB; Region: sufB; TIGR01980 881621007079 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 881621007080 trimerization site [polypeptide binding]; other site 881621007081 active site 881621007082 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621007083 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 881621007084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621007085 catalytic residue [active] 881621007086 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 881621007087 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 881621007088 FeS assembly ATPase SufC; Region: sufC; TIGR01978 881621007089 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 881621007090 Walker A/P-loop; other site 881621007091 ATP binding site [chemical binding]; other site 881621007092 Q-loop/lid; other site 881621007093 ABC transporter signature motif; other site 881621007094 Walker B; other site 881621007095 D-loop; other site 881621007096 H-loop/switch region; other site 881621007097 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 881621007098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621007099 ABC-ATPase subunit interface; other site 881621007100 putative PBP binding loops; other site 881621007101 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 881621007102 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 881621007103 Walker A/P-loop; other site 881621007104 ATP binding site [chemical binding]; other site 881621007105 Q-loop/lid; other site 881621007106 ABC transporter signature motif; other site 881621007107 Walker B; other site 881621007108 D-loop; other site 881621007109 H-loop/switch region; other site 881621007110 NIL domain; Region: NIL; cl09633 881621007111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 881621007112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621007113 dimer interface [polypeptide binding]; other site 881621007114 phosphorylation site [posttranslational modification] 881621007115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007116 ATP binding site [chemical binding]; other site 881621007117 Mg2+ binding site [ion binding]; other site 881621007118 G-X-G motif; other site 881621007119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621007121 active site 881621007122 phosphorylation site [posttranslational modification] 881621007123 intermolecular recognition site; other site 881621007124 dimerization interface [polypeptide binding]; other site 881621007125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621007126 DNA binding site [nucleotide binding] 881621007127 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007128 Cation efflux family; Region: Cation_efflux; cl00316 881621007129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621007130 catalytic residues [active] 881621007131 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 881621007132 lipoyl attachment site [posttranslational modification]; other site 881621007133 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 881621007134 putative ArsC-like catalytic residues; other site 881621007135 putative TRX-like catalytic residues [active] 881621007136 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007137 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007138 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 881621007139 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 881621007140 Walker A/P-loop; other site 881621007141 ATP binding site [chemical binding]; other site 881621007142 Q-loop/lid; other site 881621007143 ABC transporter signature motif; other site 881621007144 Walker B; other site 881621007145 D-loop; other site 881621007146 H-loop/switch region; other site 881621007147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 881621007148 ABC-ATPase subunit interface; other site 881621007149 dimer interface [polypeptide binding]; other site 881621007150 putative PBP binding regions; other site 881621007151 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 881621007152 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 881621007153 intersubunit interface [polypeptide binding]; other site 881621007154 Predicted esterase [General function prediction only]; Region: COG0627 881621007155 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007156 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 881621007157 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 881621007158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007159 catalytic residue [active] 881621007160 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 881621007161 CAT RNA binding domain; Region: CAT_RBD; cl03904 881621007162 transcriptional antiterminator BglG; Provisional; Region: PRK09772 881621007163 PRD domain; Region: PRD; pfam00874 881621007164 PRD domain; Region: PRD; pfam00874 881621007165 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 881621007166 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 881621007167 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621007168 truncated, c-terminal part 881621007169 truncated, N-terminal part 881621007170 Predicted transcriptional regulator [Transcription]; Region: COG2378 881621007171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621007172 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 881621007173 putative active site [active] 881621007174 similar to glycosidase, C-terminal part 881621007175 similar to glycosidase, N-terminal part 881621007176 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007177 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 881621007178 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 881621007179 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 881621007180 active site 881621007181 catalytic site [active] 881621007182 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 881621007183 putative metal binding site [ion binding]; other site 881621007184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 881621007185 non-specific DNA binding site [nucleotide binding]; other site 881621007186 salt bridge; other site 881621007187 sequence-specific DNA binding site [nucleotide binding]; other site 881621007188 C-terminal domain; Region: RGG_Cterm; TIGR01716 881621007189 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 881621007190 SmpB-tmRNA interface; other site 881621007191 ribonuclease R; Region: RNase_R; TIGR02063 881621007192 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 881621007193 RNB domain; Region: RNB; pfam00773 881621007194 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 881621007195 RNA binding site [nucleotide binding]; other site 881621007196 Esterase/lipase [General function prediction only]; Region: COG1647 881621007197 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007198 Esterase/lipase [General function prediction only]; Region: COG1647 881621007199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007200 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007201 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 881621007202 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621007203 enolase; Provisional; Region: eno; PRK00077 881621007204 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 881621007205 dimer interface [polypeptide binding]; other site 881621007206 metal binding site [ion binding]; metal-binding site 881621007207 substrate binding pocket [chemical binding]; other site 881621007208 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 881621007209 Sulfatase; Region: Sulfatase; cl10460 881621007210 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 881621007211 substrate binding site [chemical binding]; other site 881621007212 dimer interface [polypeptide binding]; other site 881621007213 catalytic triad [active] 881621007214 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 881621007215 substrate binding site [chemical binding]; other site 881621007216 hinge regions; other site 881621007217 ADP binding site [chemical binding]; other site 881621007218 catalytic site [active] 881621007219 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 881621007220 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 881621007221 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 881621007222 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 881621007223 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 881621007224 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 881621007225 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 881621007226 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 881621007227 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 881621007228 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 881621007229 active site 881621007230 dimer interface [polypeptide binding]; other site 881621007231 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 881621007232 Protein export membrane protein; Region: SecD_SecF; cl14618 881621007233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621007235 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 881621007236 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007238 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007239 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007240 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621007241 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 881621007242 similar to internalin B and to Ami protein,partial 881621007243 similar to chitinase and chitin binding protein,C-terminal part 881621007244 similar to chitinase and chitin binding protein,N-terminal part 881621007245 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 881621007246 oligomer interface [polypeptide binding]; other site 881621007247 active site residues [active] 881621007248 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 881621007249 similar to putative peptidoglycan linked protein (LPXTG motif), partial 881621007250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 881621007251 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 881621007252 active site 881621007253 FMN binding site [chemical binding]; other site 881621007254 substrate binding site [chemical binding]; other site 881621007255 homotetramer interface [polypeptide binding]; other site 881621007256 catalytic residue [active] 881621007257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 881621007258 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 881621007259 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 881621007260 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 881621007261 phosphate binding site [ion binding]; other site 881621007262 putative substrate binding pocket [chemical binding]; other site 881621007263 dimer interface [polypeptide binding]; other site 881621007264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621007265 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 881621007266 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 881621007267 active site 881621007268 substrate binding site [chemical binding]; other site 881621007269 metal binding site [ion binding]; metal-binding site 881621007270 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 881621007271 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 881621007272 active site 881621007273 catalytic residues [active] 881621007274 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 881621007275 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 881621007276 NAD binding site [chemical binding]; other site 881621007277 homodimer interface [polypeptide binding]; other site 881621007278 active site 881621007279 substrate binding site [chemical binding]; other site 881621007280 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 881621007281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621007284 binding surface 881621007285 TPR motif; other site 881621007286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 881621007287 binding surface 881621007288 TPR motif; other site 881621007289 similar to repressor protein 881621007290 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 881621007291 trimer interface [polypeptide binding]; other site 881621007292 active site 881621007293 substrate binding site [chemical binding]; other site 881621007294 CoA binding site [chemical binding]; other site 881621007295 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 881621007296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621007297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621007298 motif II; other site 881621007299 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 881621007300 HPr kinase/phosphorylase; Provisional; Region: PRK05428 881621007301 DRTGG domain; Region: DRTGG; cl12147 881621007302 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 881621007303 Hpr binding site; other site 881621007304 active site 881621007305 homohexamer subunit interaction site [polypeptide binding]; other site 881621007306 Membrane protein of unknown function; Region: DUF360; cl00850 881621007307 PspC domain; Region: PspC; cl00864 881621007308 PspC domain; Region: PspC; cl00864 881621007309 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007310 Uncharacterized conserved protein [Function unknown]; Region: COG3595 881621007311 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 881621007312 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621007313 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 881621007314 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 881621007315 excinuclease ABC subunit B; Provisional; Region: PRK05298 881621007316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007317 ATP binding site [chemical binding]; other site 881621007318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007319 nucleotide binding region [chemical binding]; other site 881621007320 ATP-binding site [chemical binding]; other site 881621007321 Ultra-violet resistance protein B; Region: UvrB; pfam12344 881621007322 UvrB/uvrC motif; Region: UVR; pfam02151 881621007323 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 881621007324 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621007325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 881621007326 dimerization interface [polypeptide binding]; other site 881621007327 putative DNA binding site [nucleotide binding]; other site 881621007328 putative Zn2+ binding site [ion binding]; other site 881621007329 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 881621007330 PhoU domain; Region: PhoU; pfam01895 881621007331 PhoU domain; Region: PhoU; pfam01895 881621007332 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 881621007333 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 881621007334 Walker A/P-loop; other site 881621007335 ATP binding site [chemical binding]; other site 881621007336 Q-loop/lid; other site 881621007337 ABC transporter signature motif; other site 881621007338 Walker B; other site 881621007339 D-loop; other site 881621007340 H-loop/switch region; other site 881621007341 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 881621007342 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 881621007343 Walker A/P-loop; other site 881621007344 ATP binding site [chemical binding]; other site 881621007345 Q-loop/lid; other site 881621007346 ABC transporter signature motif; other site 881621007347 Walker B; other site 881621007348 D-loop; other site 881621007349 H-loop/switch region; other site 881621007350 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 881621007351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621007352 dimer interface [polypeptide binding]; other site 881621007353 conserved gate region; other site 881621007354 putative PBP binding loops; other site 881621007355 ABC-ATPase subunit interface; other site 881621007356 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 881621007357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621007358 dimer interface [polypeptide binding]; other site 881621007359 conserved gate region; other site 881621007360 putative PBP binding loops; other site 881621007361 ABC-ATPase subunit interface; other site 881621007362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621007363 sensory histidine kinase CreC; Provisional; Region: PRK11100 881621007364 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 881621007365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 881621007366 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 881621007367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621007368 dimer interface [polypeptide binding]; other site 881621007369 phosphorylation site [posttranslational modification] 881621007370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007371 ATP binding site [chemical binding]; other site 881621007372 Mg2+ binding site [ion binding]; other site 881621007373 G-X-G motif; other site 881621007374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621007376 active site 881621007377 phosphorylation site [posttranslational modification] 881621007378 intermolecular recognition site; other site 881621007379 dimerization interface [polypeptide binding]; other site 881621007380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621007381 DNA binding site [nucleotide binding] 881621007382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 881621007383 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 881621007384 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 881621007385 putative active site [active] 881621007386 catalytic site [active] 881621007387 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 881621007388 putative active site [active] 881621007389 catalytic site [active] 881621007390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007391 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 881621007392 Peptidase family M23; Region: Peptidase_M23; pfam01551 881621007393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 881621007394 NlpC/P60 family; Region: NLPC_P60; cl11438 881621007395 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 881621007396 FtsX-like permease family; Region: FtsX; pfam02687 881621007397 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 881621007398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621007399 Walker A/P-loop; other site 881621007400 ATP binding site [chemical binding]; other site 881621007401 Q-loop/lid; other site 881621007402 ABC transporter signature motif; other site 881621007403 Walker B; other site 881621007404 D-loop; other site 881621007405 H-loop/switch region; other site 881621007406 Uncharacterized conserved protein [Function unknown]; Region: COG1284 881621007407 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007408 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 881621007409 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 881621007410 peptide chain release factor 2; Validated; Region: prfB; PRK00578 881621007411 RF-1 domain; Region: RF-1; cl02875 881621007412 RF-1 domain; Region: RF-1; cl02875 881621007413 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 881621007414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621007415 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 881621007416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007417 nucleotide binding region [chemical binding]; other site 881621007418 ATP-binding site [chemical binding]; other site 881621007419 SEC-C motif; Region: SEC-C; cl12132 881621007420 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 881621007421 30S subunit binding site; other site 881621007422 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 881621007423 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621007424 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 881621007425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621007426 ATP binding site [chemical binding]; other site 881621007427 putative Mg++ binding site [ion binding]; other site 881621007428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621007429 nucleotide binding region [chemical binding]; other site 881621007430 ATP-binding site [chemical binding]; other site 881621007431 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 881621007432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 881621007433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621007434 active site 881621007435 phosphorylation site [posttranslational modification] 881621007436 intermolecular recognition site; other site 881621007437 dimerization interface [polypeptide binding]; other site 881621007438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 881621007439 DNA binding residues [nucleotide binding] 881621007440 dimerization interface [polypeptide binding]; other site 881621007441 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 881621007442 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 881621007443 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 881621007444 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 881621007445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621007446 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621007447 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 881621007448 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 881621007449 Mg++ binding site [ion binding]; other site 881621007450 putative catalytic motif [active] 881621007451 substrate binding site [chemical binding]; other site 881621007452 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 881621007453 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 881621007454 active site 881621007455 octamer interface [polypeptide binding]; other site 881621007456 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 881621007457 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007458 putative peptidoglycan binding site; other site 881621007459 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 881621007460 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007461 putative peptidoglycan binding site; other site 881621007462 3D domain; Region: 3D; cl01439 881621007463 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 881621007464 dimer interface [polypeptide binding]; other site 881621007465 ssDNA binding site [nucleotide binding]; other site 881621007466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 881621007467 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 881621007468 rod shape-determining protein Mbl; Provisional; Region: PRK13928 881621007469 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 881621007470 ATP binding site [chemical binding]; other site 881621007471 Cell division protein FtsA; Region: FtsA; cl11496 881621007472 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 881621007473 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621007474 hinge; other site 881621007475 active site 881621007476 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 881621007477 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 881621007478 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 881621007479 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 881621007480 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 881621007481 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 881621007482 alpha subunit interaction interface [polypeptide binding]; other site 881621007483 Walker A motif; other site 881621007484 ATP binding site [chemical binding]; other site 881621007485 Walker B motif; other site 881621007486 inhibitor binding site; inhibition site 881621007487 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621007488 ATP synthase; Region: ATP-synt; cl00365 881621007489 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 881621007490 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 881621007491 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 881621007492 beta subunit interaction interface [polypeptide binding]; other site 881621007493 Walker A motif; other site 881621007494 ATP binding site [chemical binding]; other site 881621007495 Walker B motif; other site 881621007496 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 881621007497 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 881621007498 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 881621007499 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 881621007500 ATP synthase subunit C; Region: ATP-synt_C; cl00466 881621007501 ATP synthase A chain; Region: ATP-synt_A; cl00413 881621007502 ATP synthase I chain; Region: ATP_synt_I; cl09170 881621007503 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 881621007504 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 881621007505 active site 881621007506 homodimer interface [polypeptide binding]; other site 881621007507 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 881621007508 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 881621007509 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 881621007510 dimer interface [polypeptide binding]; other site 881621007511 glycine-pyridoxal phosphate binding site [chemical binding]; other site 881621007512 active site 881621007513 folate binding site [chemical binding]; other site 881621007514 Low molecular weight phosphatase family; Region: LMWPc; cd00115 881621007515 Active site [active] 881621007516 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 881621007517 SUA5 domain; Region: SUA5; pfam03481 881621007518 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 881621007519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621007520 S-adenosylmethionine binding site [chemical binding]; other site 881621007521 peptide chain release factor 1; Validated; Region: prfA; PRK00591 881621007522 RF-1 domain; Region: RF-1; cl02875 881621007523 RF-1 domain; Region: RF-1; cl02875 881621007524 Thymidine kinase; Region: TK; cl00631 881621007525 homoserine kinase; Provisional; Region: PRK01212 881621007526 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 881621007527 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 881621007528 threonine synthase; Reviewed; Region: PRK06721 881621007529 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 881621007530 homodimer interface [polypeptide binding]; other site 881621007531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621007532 catalytic residue [active] 881621007533 homoserine dehydrogenase; Provisional; Region: PRK06349 881621007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007535 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 881621007536 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 881621007537 similar to transcription regulator MerR family,partial, C-terminal part 881621007538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007539 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 881621007540 Cupin domain; Region: Cupin_2; cl09118 881621007541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 881621007542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621007543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 881621007544 dimerization interface [polypeptide binding]; other site 881621007545 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 881621007546 GtrA-like protein; Region: GtrA; cl00971 881621007547 transcription termination factor Rho; Provisional; Region: rho; PRK09376 881621007548 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 881621007549 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 881621007550 RNA binding site [nucleotide binding]; other site 881621007551 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 881621007552 multimer interface [polypeptide binding]; other site 881621007553 Walker A motif; other site 881621007554 ATP binding site [chemical binding]; other site 881621007555 Walker B motif; other site 881621007556 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 881621007557 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 881621007558 hinge; other site 881621007559 active site 881621007560 Predicted integral membrane protein [Function unknown]; Region: COG0392 881621007561 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 881621007562 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 881621007563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621007564 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 881621007565 putative ADP-binding pocket [chemical binding]; other site 881621007566 hypothetical protein; Provisional; Region: PRK08185 881621007567 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 881621007568 intersubunit interface [polypeptide binding]; other site 881621007569 active site 881621007570 zinc binding site [ion binding]; other site 881621007571 Na+ binding site [ion binding]; other site 881621007572 putative lipid kinase; Reviewed; Region: PRK13055 881621007573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 881621007574 CTP synthetase; Validated; Region: pyrG; PRK05380 881621007575 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 881621007576 Catalytic site [active] 881621007577 Active site [active] 881621007578 UTP binding site [chemical binding]; other site 881621007579 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 881621007580 active site 881621007581 putative oxyanion hole; other site 881621007582 catalytic triad [active] 881621007583 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 881621007584 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 881621007585 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 881621007586 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 881621007587 active site 881621007588 HIGH motif; other site 881621007589 KMSK motif region; other site 881621007590 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 881621007591 tRNA binding surface [nucleotide binding]; other site 881621007592 anticodon binding site; other site 881621007593 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 881621007594 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 881621007595 active site 881621007596 putative substrate binding region [chemical binding]; other site 881621007597 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 881621007598 active site 1 [active] 881621007599 dimer interface [polypeptide binding]; other site 881621007600 hexamer interface [polypeptide binding]; other site 881621007601 active site 2 [active] 881621007602 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 881621007603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 881621007604 Zn2+ binding site [ion binding]; other site 881621007605 Mg2+ binding site [ion binding]; other site 881621007606 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 881621007607 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 881621007608 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 881621007609 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 881621007610 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 881621007611 peptide binding site [polypeptide binding]; other site 881621007612 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 881621007613 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 881621007614 catalytic triad [active] 881621007615 metal binding site [ion binding]; metal-binding site 881621007616 conserved cis-peptide bond; other site 881621007617 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 881621007618 folate binding site [chemical binding]; other site 881621007619 NADP+ binding site [chemical binding]; other site 881621007620 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 881621007621 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 881621007622 putative NAD(P) binding site [chemical binding]; other site 881621007623 dimer interface [polypeptide binding]; other site 881621007624 Cation efflux family; Region: Cation_efflux; cl00316 881621007625 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 881621007626 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621007627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621007628 active site 881621007629 motif I; other site 881621007630 motif II; other site 881621007631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621007632 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 881621007633 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 881621007634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 881621007635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621007636 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 881621007637 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 881621007638 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 881621007639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 881621007640 catalytic loop [active] 881621007641 iron binding site [ion binding]; other site 881621007642 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 881621007643 4Fe-4S binding domain; Region: Fer4; cl02805 881621007644 4Fe-4S binding domain; Region: Fer4; cl02805 881621007645 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 881621007646 [4Fe-4S] binding site [ion binding]; other site 881621007647 molybdopterin cofactor binding site; other site 881621007648 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 881621007649 molybdopterin cofactor binding site; other site 881621007650 Uncharacterized conserved protein [Function unknown]; Region: COG1912 881621007651 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 881621007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621007654 putative substrate translocation pore; other site 881621007655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621007656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621007658 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 881621007659 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007660 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621007661 Leucine-rich repeats; other site 881621007662 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007663 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007664 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007665 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 881621007666 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 881621007667 LRR adjacent; Region: LRR_adjacent; pfam08191 881621007668 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 881621007669 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 881621007670 Walker A motif; other site 881621007671 similar to putative endo-beta-N-acetylglucosaminidase, pseudogene, internal part 881621007672 similar to putative endo-beta-N-acetylglucosaminidase, N-terminal part 881621007673 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 881621007674 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 881621007675 23S rRNA interface [nucleotide binding]; other site 881621007676 L3 interface [polypeptide binding]; other site 881621007677 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 881621007678 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 881621007679 dimerization interface 3.5A [polypeptide binding]; other site 881621007680 active site 881621007681 Cobalt transport protein; Region: CbiQ; cl00463 881621007682 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 881621007683 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621007684 Walker A/P-loop; other site 881621007685 ATP binding site [chemical binding]; other site 881621007686 Q-loop/lid; other site 881621007687 ABC transporter signature motif; other site 881621007688 Walker B; other site 881621007689 D-loop; other site 881621007690 H-loop/switch region; other site 881621007691 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 881621007692 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 881621007693 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621007694 Walker A/P-loop; other site 881621007695 ATP binding site [chemical binding]; other site 881621007696 Q-loop/lid; other site 881621007697 ABC transporter signature motif; other site 881621007698 Walker B; other site 881621007699 D-loop; other site 881621007700 H-loop/switch region; other site 881621007701 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 881621007702 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 881621007703 MgtC family; Region: MgtC; cl12207 881621007704 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 881621007705 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 881621007706 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 881621007707 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 881621007708 alphaNTD - beta interaction site [polypeptide binding]; other site 881621007709 alphaNTD homodimer interface [polypeptide binding]; other site 881621007710 alphaNTD - beta' interaction site [polypeptide binding]; other site 881621007711 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 881621007712 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 881621007713 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 881621007714 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 881621007715 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 881621007716 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 881621007717 rRNA binding site [nucleotide binding]; other site 881621007718 predicted 30S ribosome binding site; other site 881621007719 adenylate kinase; Reviewed; Region: adk; PRK00279 881621007720 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 881621007721 AMP-binding site [chemical binding]; other site 881621007722 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 881621007723 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 881621007724 SecY translocase; Region: SecY; pfam00344 881621007725 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 881621007726 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 881621007727 23S rRNA binding site [nucleotide binding]; other site 881621007728 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 881621007729 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 881621007730 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 881621007731 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 881621007732 5S rRNA interface [nucleotide binding]; other site 881621007733 L27 interface [polypeptide binding]; other site 881621007734 23S rRNA interface [nucleotide binding]; other site 881621007735 L5 interface [polypeptide binding]; other site 881621007736 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 881621007737 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621007738 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 881621007739 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 881621007740 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 881621007741 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 881621007742 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 881621007743 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 881621007744 KOW motif; Region: KOW; cl00354 881621007745 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 881621007746 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 881621007747 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 881621007748 23S rRNA interface [nucleotide binding]; other site 881621007749 putative translocon interaction site; other site 881621007750 signal recognition particle (SRP54) interaction site; other site 881621007751 L23 interface [polypeptide binding]; other site 881621007752 trigger factor interaction site; other site 881621007753 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 881621007754 23S rRNA interface [nucleotide binding]; other site 881621007755 5S rRNA interface [nucleotide binding]; other site 881621007756 putative antibiotic binding site [chemical binding]; other site 881621007757 L25 interface [polypeptide binding]; other site 881621007758 L27 interface [polypeptide binding]; other site 881621007759 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 881621007760 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 881621007761 G-X-X-G motif; other site 881621007762 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 881621007763 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 881621007764 putative translocon binding site; other site 881621007765 protein-rRNA interface [nucleotide binding]; other site 881621007766 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 881621007767 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 881621007768 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 881621007769 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 881621007770 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 881621007771 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 881621007772 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 881621007773 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 881621007774 Cobalt transport protein; Region: CbiQ; cl00463 881621007775 UbiA prenyltransferase family; Region: UbiA; cl00337 881621007776 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 881621007777 ApbE family; Region: ApbE; cl00643 881621007778 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621007779 FMN-binding domain; Region: FMN_bind; cl01081 881621007780 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 881621007781 FMN-binding domain; Region: FMN_bind; cl01081 881621007782 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 881621007783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621007784 DoxX; Region: DoxX; cl00976 881621007785 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 881621007786 trimer interface [polypeptide binding]; other site 881621007787 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 881621007788 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 881621007789 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 881621007790 substrate binding pocket [chemical binding]; other site 881621007791 chain length determination region; other site 881621007792 substrate-Mg2+ binding site; other site 881621007793 catalytic residues [active] 881621007794 aspartate-rich region 1; other site 881621007795 active site lid residues [active] 881621007796 aspartate-rich region 2; other site 881621007797 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 881621007798 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 881621007799 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 881621007800 hypothetical protein; Provisional; Region: PRK02947 881621007801 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621007802 putative active site [active] 881621007803 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 881621007804 Creatinine amidohydrolase; Region: Creatininase; cl00618 881621007805 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 881621007806 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 881621007807 active site 881621007808 substrate binding pocket [chemical binding]; other site 881621007809 homodimer interaction site [polypeptide binding]; other site 881621007810 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621007811 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 881621007812 P-loop; other site 881621007813 active site 881621007814 phosphorylation site [posttranslational modification] 881621007815 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007816 active site 881621007817 phosphorylation site [posttranslational modification] 881621007818 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621007819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621007820 PRD domain; Region: PRD; pfam00874 881621007821 PRD domain; Region: PRD; pfam00874 881621007822 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621007823 P-loop; other site 881621007824 active site 881621007825 phosphorylation site [posttranslational modification] 881621007826 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007827 active site 881621007828 phosphorylation site [posttranslational modification] 881621007829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621007830 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 881621007831 Walker A/P-loop; other site 881621007832 ATP binding site [chemical binding]; other site 881621007833 Q-loop/lid; other site 881621007834 ABC transporter signature motif; other site 881621007835 Walker B; other site 881621007836 D-loop; other site 881621007837 H-loop/switch region; other site 881621007838 elongation factor Tu; Reviewed; Region: PRK00049 881621007839 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 881621007840 G1 box; other site 881621007841 GEF interaction site [polypeptide binding]; other site 881621007842 GTP/Mg2+ binding site [chemical binding]; other site 881621007843 Switch I region; other site 881621007844 G2 box; other site 881621007845 G3 box; other site 881621007846 Switch II region; other site 881621007847 G4 box; other site 881621007848 G5 box; other site 881621007849 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 881621007850 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 881621007851 Antibiotic Binding Site [chemical binding]; other site 881621007852 elongation factor G; Reviewed; Region: PRK00007 881621007853 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 881621007854 G1 box; other site 881621007855 putative GEF interaction site [polypeptide binding]; other site 881621007856 GTP/Mg2+ binding site [chemical binding]; other site 881621007857 Switch I region; other site 881621007858 G2 box; other site 881621007859 G3 box; other site 881621007860 Switch II region; other site 881621007861 G4 box; other site 881621007862 G5 box; other site 881621007863 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 881621007864 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 881621007865 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 881621007866 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 881621007867 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 881621007868 S17 interaction site [polypeptide binding]; other site 881621007869 S8 interaction site; other site 881621007870 16S rRNA interaction site [nucleotide binding]; other site 881621007871 streptomycin interaction site [chemical binding]; other site 881621007872 23S rRNA interaction site [nucleotide binding]; other site 881621007873 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 881621007874 similar to deoxyguanosinetriphosphate triphosphohydrolase, N-terminal part 881621007875 similar to deoxyguanosinetriphosphate triphosphohydrolase, C-terminal part 881621007876 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 881621007877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 881621007878 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 881621007879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 881621007880 Coenzyme A binding pocket [chemical binding]; other site 881621007881 MucBP domain; Region: MucBP; pfam06458 881621007882 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621007883 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 881621007884 Substrate binding site [chemical binding]; other site 881621007885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 881621007886 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621007887 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621007888 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621007889 substrate binding site [chemical binding]; other site 881621007890 hexamer interface [polypeptide binding]; other site 881621007891 metal binding site [ion binding]; metal-binding site 881621007892 similar to transketolase, C-terminal part 881621007893 similar to transketolase, N-terminal part 881621007894 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 881621007895 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 881621007896 substrate binding site [chemical binding]; other site 881621007897 hexamer interface [polypeptide binding]; other site 881621007898 metal binding site [ion binding]; metal-binding site 881621007899 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621007900 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621007901 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 881621007902 putative NAD(P) binding site [chemical binding]; other site 881621007903 catalytic Zn binding site [ion binding]; other site 881621007904 structural Zn binding site [ion binding]; other site 881621007905 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621007906 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 881621007907 putative NAD(P) binding site [chemical binding]; other site 881621007908 catalytic Zn binding site [ion binding]; other site 881621007909 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 881621007910 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 881621007911 P-loop; other site 881621007912 active site 881621007913 phosphorylation site [posttranslational modification] 881621007914 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007915 active site 881621007916 phosphorylation site [posttranslational modification] 881621007917 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 881621007918 PRD domain; Region: PRD; pfam00874 881621007919 PRD domain; Region: PRD; pfam00874 881621007920 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 881621007921 P-loop; other site 881621007922 active site 881621007923 phosphorylation site [posttranslational modification] 881621007924 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 881621007925 active site 881621007926 phosphorylation site [posttranslational modification] 881621007927 Predicted membrane protein [Function unknown]; Region: COG4905 881621007928 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 881621007929 Protein of unknown function (DUF419); Region: DUF419; cl15265 881621007930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 881621007931 active site 881621007932 metal binding site [ion binding]; metal-binding site 881621007933 Helix-turn-helix domain; Region: HTH_18; pfam12833 881621007934 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 881621007935 Ligand Binding Site [chemical binding]; other site 881621007936 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 881621007937 Similar to UV-damage repair protein, truncated, in frame stop codon 881621007938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 881621007939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 881621007940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 881621007941 active site 881621007942 phosphorylation site [posttranslational modification] 881621007943 intermolecular recognition site; other site 881621007944 dimerization interface [polypeptide binding]; other site 881621007945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 881621007946 DNA binding site [nucleotide binding] 881621007947 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 881621007948 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 881621007949 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 881621007950 Ligand Binding Site [chemical binding]; other site 881621007951 GAF domain; Region: GAF; cl00853 881621007952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 881621007953 dimer interface [polypeptide binding]; other site 881621007954 phosphorylation site [posttranslational modification] 881621007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 881621007956 ATP binding site [chemical binding]; other site 881621007957 Mg2+ binding site [ion binding]; other site 881621007958 G-X-G motif; other site 881621007959 K+-transporting ATPase, c chain; Region: KdpC; cl00944 881621007960 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 881621007961 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621007962 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 881621007963 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 881621007964 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621007965 active site 881621007966 P-loop; other site 881621007967 phosphorylation site [posttranslational modification] 881621007968 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621007969 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621007970 methionine cluster; other site 881621007971 active site 881621007972 phosphorylation site [posttranslational modification] 881621007973 metal binding site [ion binding]; metal-binding site 881621007974 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007975 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 881621007976 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 881621007977 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 881621007978 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 881621007979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621007980 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 881621007981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 881621007982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 881621007983 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 881621007984 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007985 putative peptidoglycan binding site; other site 881621007986 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007987 putative peptidoglycan binding site; other site 881621007988 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 881621007989 putative peptidoglycan binding site; other site 881621007990 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 881621007991 thymidylate kinase; Validated; Region: tmk; PRK00698 881621007992 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 881621007993 TMP-binding site; other site 881621007994 ATP-binding site [chemical binding]; other site 881621007995 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 881621007996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 881621007997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 881621007998 catalytic residue [active] 881621007999 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 881621008000 similar to unknown protein, truncated (pseudogene) 881621008001 similar to transposase, pseudogene 881621008002 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 881621008003 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 881621008004 DAK2 domain; Region: Dak2; cl03685 881621008005 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 881621008006 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008007 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008008 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008009 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621008010 putative active site [active] 881621008011 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 881621008012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621008013 active site 881621008014 motif I; other site 881621008015 motif II; other site 881621008016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621008017 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 881621008018 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 881621008019 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 881621008020 putative trimer interface [polypeptide binding]; other site 881621008021 putative CoA binding site [chemical binding]; other site 881621008022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 881621008023 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008024 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008025 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 881621008026 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 881621008027 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 881621008028 inhibitor-cofactor binding pocket; inhibition site 881621008029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008030 catalytic residue [active] 881621008031 Bacterial sugar transferase; Region: Bac_transf; cl00939 881621008032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008033 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 881621008034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 881621008035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 881621008036 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 881621008037 MatE; Region: MatE; cl10513 881621008038 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 881621008039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008040 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 881621008041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008042 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 881621008043 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 881621008044 NAD(P) binding site [chemical binding]; other site 881621008045 homodimer interface [polypeptide binding]; other site 881621008046 substrate binding site [chemical binding]; other site 881621008047 active site 881621008048 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 881621008049 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 881621008050 Chain length determinant protein; Region: Wzz; cl01623 881621008051 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 881621008052 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 881621008053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 881621008054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621008055 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 881621008056 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 881621008057 nudix motif; other site 881621008058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 881621008059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 881621008060 active site 881621008061 catalytic tetrad [active] 881621008062 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008063 active site 881621008064 methionine cluster; other site 881621008065 phosphorylation site [posttranslational modification] 881621008066 metal binding site [ion binding]; metal-binding site 881621008067 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621008068 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621008069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621008070 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 881621008071 active site 881621008072 motif I; other site 881621008073 motif II; other site 881621008074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 881621008075 similar to glycosyl hydrolase, internal part 881621008076 similar to glycosyl hydrolase, N-terminal part 881621008077 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621008078 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008079 active site 881621008080 P-loop; other site 881621008081 phosphorylation site [posttranslational modification] 881621008082 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 881621008083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 881621008084 DNA-binding site [nucleotide binding]; DNA binding site 881621008085 UTRA domain; Region: UTRA; cl01230 881621008086 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 881621008087 recombination protein RecR; Reviewed; Region: recR; PRK00076 881621008088 RecR protein; Region: RecR; pfam02132 881621008089 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 881621008090 putative active site [active] 881621008091 putative metal-binding site [ion binding]; other site 881621008092 tetramer interface [polypeptide binding]; other site 881621008093 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 881621008094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 881621008095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 881621008096 Walker A motif; other site 881621008097 ATP binding site [chemical binding]; other site 881621008098 Walker B motif; other site 881621008099 arginine finger; other site 881621008100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 881621008101 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 881621008102 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621008103 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 881621008104 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 881621008105 N- and C-terminal domain interface [polypeptide binding]; other site 881621008106 putative active site [active] 881621008107 catalytic site [active] 881621008108 metal binding site [ion binding]; metal-binding site 881621008109 carbohydrate binding site [chemical binding]; other site 881621008110 ATP binding site [chemical binding]; other site 881621008111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 881621008112 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 881621008113 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008114 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 881621008115 Walker A/P-loop; other site 881621008116 ATP binding site [chemical binding]; other site 881621008117 Q-loop/lid; other site 881621008118 ABC transporter signature motif; other site 881621008119 Walker B; other site 881621008120 D-loop; other site 881621008121 H-loop/switch region; other site 881621008122 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 881621008123 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621008125 Walker A/P-loop; other site 881621008126 ATP binding site [chemical binding]; other site 881621008127 Q-loop/lid; other site 881621008128 ABC transporter signature motif; other site 881621008129 Walker B; other site 881621008130 D-loop; other site 881621008131 H-loop/switch region; other site 881621008132 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 881621008133 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 881621008134 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 881621008135 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 881621008136 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 881621008137 nucleoside/Zn binding site; other site 881621008138 dimer interface [polypeptide binding]; other site 881621008139 catalytic motif [active] 881621008140 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 881621008141 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 881621008142 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 881621008143 active site 881621008144 trimer interface [polypeptide binding]; other site 881621008145 allosteric site; other site 881621008146 active site lid [active] 881621008147 hexamer (dimer of trimers) interface [polypeptide binding]; other site 881621008148 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008149 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 881621008150 DNA binding residues [nucleotide binding] 881621008151 drug binding residues [chemical binding]; other site 881621008152 dimer interface [polypeptide binding]; other site 881621008153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 881621008154 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 881621008155 dimer interface [polypeptide binding]; other site 881621008156 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 881621008157 MatE; Region: MatE; cl10513 881621008158 MatE; Region: MatE; cl10513 881621008159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621008160 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 881621008161 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 881621008162 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 881621008163 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 881621008164 DNA binding residues [nucleotide binding] 881621008165 putative dimer interface [polypeptide binding]; other site 881621008166 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 881621008167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621008168 motif II; other site 881621008169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008171 DNA binding site [nucleotide binding] 881621008172 domain linker motif; other site 881621008173 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 881621008174 putative dimerization interface [polypeptide binding]; other site 881621008175 putative ligand binding site [chemical binding]; other site 881621008176 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 881621008177 NAD+ binding site [chemical binding]; other site 881621008178 substrate binding site [chemical binding]; other site 881621008179 putative Zn binding site [ion binding]; other site 881621008180 TfoX N-terminal domain; Region: TfoX_N; cl01167 881621008181 drug efflux system protein MdtG; Provisional; Region: PRK09874 881621008182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008183 putative substrate translocation pore; other site 881621008184 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl15350 881621008185 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization...; Region: SH3; cl15350 881621008186 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 881621008187 active site 881621008188 intersubunit interactions; other site 881621008189 catalytic residue [active] 881621008190 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 881621008191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621008192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008193 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621008195 Walker A/P-loop; other site 881621008196 ATP binding site [chemical binding]; other site 881621008197 Q-loop/lid; other site 881621008198 ABC transporter signature motif; other site 881621008199 Walker B; other site 881621008200 D-loop; other site 881621008201 H-loop/switch region; other site 881621008202 TfoX N-terminal domain; Region: TfoX_N; cl01167 881621008203 seryl-tRNA synthetase; Provisional; Region: PRK05431 881621008204 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 881621008205 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 881621008206 dimer interface [polypeptide binding]; other site 881621008207 active site 881621008208 motif 1; other site 881621008209 motif 2; other site 881621008210 motif 3; other site 881621008211 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 881621008212 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 881621008213 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 881621008214 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 881621008215 glutamine binding [chemical binding]; other site 881621008216 catalytic triad [active] 881621008217 aminodeoxychorismate synthase; Provisional; Region: PRK07508 881621008218 chorismate binding enzyme; Region: Chorismate_bind; cl10555 881621008219 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 881621008220 substrate-cofactor binding pocket; other site 881621008221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008222 catalytic residue [active] 881621008223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008224 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621008226 Walker A/P-loop; other site 881621008227 ATP binding site [chemical binding]; other site 881621008228 Q-loop/lid; other site 881621008229 ABC transporter signature motif; other site 881621008230 Walker B; other site 881621008231 D-loop; other site 881621008232 H-loop/switch region; other site 881621008233 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 881621008234 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 881621008235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 881621008236 Walker A/P-loop; other site 881621008237 ATP binding site [chemical binding]; other site 881621008238 Q-loop/lid; other site 881621008239 ABC transporter signature motif; other site 881621008240 Walker B; other site 881621008241 D-loop; other site 881621008242 H-loop/switch region; other site 881621008243 Beta-lactamase; Region: Beta-lactamase; cl01009 881621008244 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 881621008245 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 881621008246 Predicted acyl esterases [General function prediction only]; Region: COG2936 881621008247 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 881621008248 DNA topoisomerase III; Provisional; Region: PRK07726 881621008249 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 881621008250 active site 881621008251 putative interdomain interaction site [polypeptide binding]; other site 881621008252 putative metal-binding site [ion binding]; other site 881621008253 putative nucleotide binding site [chemical binding]; other site 881621008254 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 881621008255 domain I; other site 881621008256 DNA binding groove [nucleotide binding] 881621008257 phosphate binding site [ion binding]; other site 881621008258 domain II; other site 881621008259 domain III; other site 881621008260 nucleotide binding site [chemical binding]; other site 881621008261 catalytic site [active] 881621008262 domain IV; other site 881621008263 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 881621008264 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 881621008265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 881621008266 ATP binding site [chemical binding]; other site 881621008267 putative Mg++ binding site [ion binding]; other site 881621008268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 881621008269 nucleotide binding region [chemical binding]; other site 881621008270 ATP-binding site [chemical binding]; other site 881621008271 RQC domain; Region: RQC; cl09632 881621008272 HRDC domain; Region: HRDC; cl02578 881621008273 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 881621008274 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 881621008275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 881621008276 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 881621008277 active site 881621008278 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 881621008279 putative ADP-ribose binding site [chemical binding]; other site 881621008280 putative active site [active] 881621008281 Similar to ABC transporter (ATP-binding protein),C-terminal part 881621008282 Similar to ABC transporter (ATP-binding protein),N-terminal part 881621008283 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 881621008284 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 881621008285 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 881621008286 active site 881621008287 P-loop; other site 881621008288 phosphorylation site [posttranslational modification] 881621008289 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 881621008290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 881621008291 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 881621008292 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 881621008293 methionine cluster; other site 881621008294 active site 881621008295 phosphorylation site [posttranslational modification] 881621008296 metal binding site [ion binding]; metal-binding site 881621008297 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008298 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 881621008299 similar to beta-glucosidase, partial 881621008300 Similar to beta-glucoside-specific PTS system enzyme IIABC, C-terminal part 881621008301 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 881621008302 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 881621008303 putative active site [active] 881621008304 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 881621008305 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 881621008306 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 881621008307 Walker A/P-loop; other site 881621008308 ATP binding site [chemical binding]; other site 881621008309 Q-loop/lid; other site 881621008310 ABC transporter signature motif; other site 881621008311 Walker B; other site 881621008312 D-loop; other site 881621008313 H-loop/switch region; other site 881621008314 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 881621008315 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 881621008316 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 881621008317 GTP-binding protein YchF; Reviewed; Region: PRK09601 881621008318 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 881621008319 G1 box; other site 881621008320 GTP/Mg2+ binding site [chemical binding]; other site 881621008321 Switch I region; other site 881621008322 G2 box; other site 881621008323 Switch II region; other site 881621008324 G3 box; other site 881621008325 G4 box; other site 881621008326 G5 box; other site 881621008327 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 881621008328 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 881621008329 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 881621008330 tetramer interface [polypeptide binding]; other site 881621008331 heme binding pocket [chemical binding]; other site 881621008332 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 881621008333 ParB-like partition proteins; Region: parB_part; TIGR00180 881621008334 ParB-like nuclease domain; Region: ParBc; cl02129 881621008335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621008336 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 881621008337 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 881621008338 P-loop; other site 881621008339 Magnesium ion binding site [ion binding]; other site 881621008340 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 881621008341 Magnesium ion binding site [ion binding]; other site 881621008342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 881621008343 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 881621008344 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 881621008345 active site 881621008346 purine riboside binding site [chemical binding]; other site 881621008347 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 881621008348 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 881621008349 substrate binding site [chemical binding]; other site 881621008350 dimer interface [polypeptide binding]; other site 881621008351 ATP binding site [chemical binding]; other site 881621008352 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008353 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008354 Walker A/P-loop; other site 881621008355 ATP binding site [chemical binding]; other site 881621008356 Q-loop/lid; other site 881621008357 ABC transporter signature motif; other site 881621008358 Walker B; other site 881621008359 D-loop; other site 881621008360 H-loop/switch region; other site 881621008361 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 881621008362 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 881621008363 Walker A/P-loop; other site 881621008364 ATP binding site [chemical binding]; other site 881621008365 Q-loop/lid; other site 881621008366 ABC transporter signature motif; other site 881621008367 Walker B; other site 881621008368 D-loop; other site 881621008369 H-loop/switch region; other site 881621008370 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 881621008371 Cobalt transport protein; Region: CbiQ; cl00463 881621008372 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 881621008373 active site 881621008374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008376 DNA binding site [nucleotide binding] 881621008377 domain linker motif; other site 881621008378 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 881621008379 dimerization interface [polypeptide binding]; other site 881621008380 ligand binding site [chemical binding]; other site 881621008381 ParB-like partition proteins; Region: parB_part; TIGR00180 881621008382 ParB-like nuclease domain; Region: ParBc; cl02129 881621008383 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 881621008384 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 881621008385 putative active site cavity [active] 881621008386 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 881621008387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 881621008388 S-adenosylmethionine binding site [chemical binding]; other site 881621008389 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 881621008390 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 881621008391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008392 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 881621008393 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 881621008394 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 881621008395 G1 box; other site 881621008396 GTP/Mg2+ binding site [chemical binding]; other site 881621008397 Switch I region; other site 881621008398 G2 box; other site 881621008399 Switch II region; other site 881621008400 G3 box; other site 881621008401 G4 box; other site 881621008402 G5 box; other site 881621008403 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 881621008404 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 881621008405 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621008406 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 881621008407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 881621008408 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 881621008409 L-serine binding site [chemical binding]; other site 881621008410 ACT domain interface; other site 881621008411 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 881621008412 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 881621008413 homodimer interface [polypeptide binding]; other site 881621008414 substrate-cofactor binding pocket; other site 881621008415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 881621008416 catalytic residue [active] 881621008417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 881621008418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 881621008419 putative substrate translocation pore; other site 881621008420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 881621008421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 881621008422 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 881621008423 dimer interface [polypeptide binding]; other site 881621008424 FMN binding site [chemical binding]; other site 881621008425 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 881621008426 catalytic residues [active] 881621008427 beta-phosphoglucomutase; Region: bPGM; TIGR01990 881621008428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 881621008429 motif II; other site 881621008430 Glycerate kinase family; Region: Gly_kinase; cl00841 881621008431 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 881621008432 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 881621008433 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 881621008434 similar to oxidoreductases, C-terminal part 881621008435 similar to oxidoreductases, N-terminal part 881621008436 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 881621008437 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 881621008438 Metal-binding active site; metal-binding site 881621008439 AP (apurinic/apyrimidinic) site pocket; other site 881621008440 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 881621008441 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 881621008442 putative NAD(P) binding site [chemical binding]; other site 881621008443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 881621008444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621008445 dimer interface [polypeptide binding]; other site 881621008446 conserved gate region; other site 881621008447 putative PBP binding loops; other site 881621008448 ABC-ATPase subunit interface; other site 881621008449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 881621008450 dimer interface [polypeptide binding]; other site 881621008451 conserved gate region; other site 881621008452 putative PBP binding loops; other site 881621008453 ABC-ATPase subunit interface; other site 881621008454 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 881621008455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 881621008456 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 881621008457 sucrose phosphorylase; Provisional; Region: PRK13840 881621008458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 881621008459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 881621008460 DNA binding site [nucleotide binding] 881621008461 domain linker motif; other site 881621008462 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 881621008463 putative dimerization interface [polypeptide binding]; other site 881621008464 putative ligand binding site [chemical binding]; other site 881621008465 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 881621008466 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 881621008467 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 881621008468 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 881621008469 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 881621008470 G-X-X-G motif; other site 881621008471 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 881621008472 RxxxH motif; other site 881621008473 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 881621008474 Ribonuclease P; Region: Ribonuclease_P; cl00457 881621008475 Ribosomal protein L34; Region: Ribosomal_L34; cl00370