-- dump date 20140619_132235 -- class Genbank::misc_feature -- table misc_feature_note -- id note 393133000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 393133000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 393133000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133000004 Walker A motif; other site 393133000005 ATP binding site [chemical binding]; other site 393133000006 Walker B motif; other site 393133000007 arginine finger; other site 393133000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 393133000009 DnaA box-binding interface [nucleotide binding]; other site 393133000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 393133000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 393133000012 putative DNA binding surface [nucleotide binding]; other site 393133000013 dimer interface [polypeptide binding]; other site 393133000014 beta-clamp/clamp loader binding surface; other site 393133000015 beta-clamp/translesion DNA polymerase binding surface; other site 393133000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393133000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 393133000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 393133000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 393133000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 393133000021 Walker A/P-loop; other site 393133000022 ATP binding site [chemical binding]; other site 393133000023 Q-loop/lid; other site 393133000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133000025 ABC transporter signature motif; other site 393133000026 Walker B; other site 393133000027 D-loop; other site 393133000028 H-loop/switch region; other site 393133000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 393133000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133000031 Mg2+ binding site [ion binding]; other site 393133000032 G-X-G motif; other site 393133000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393133000034 anchoring element; other site 393133000035 dimer interface [polypeptide binding]; other site 393133000036 ATP binding site [chemical binding]; other site 393133000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 393133000038 active site 393133000039 putative metal-binding site [ion binding]; other site 393133000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393133000041 DNA gyrase subunit A; Validated; Region: PRK05560 393133000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393133000043 CAP-like domain; other site 393133000044 active site 393133000045 primary dimer interface [polypeptide binding]; other site 393133000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133000051 cardiolipin synthetase; Reviewed; Region: PRK12452 393133000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 393133000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 393133000054 putative active site [active] 393133000055 catalytic site [active] 393133000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 393133000057 putative active site [active] 393133000058 catalytic site [active] 393133000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393133000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133000061 Coenzyme A binding pocket [chemical binding]; other site 393133000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 393133000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393133000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393133000065 diphosphomevalonate decarboxylase; Region: PLN02407 393133000066 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 393133000067 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 393133000068 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393133000069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 393133000070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 393133000071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 393133000072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 393133000073 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 393133000074 D-pathway; other site 393133000075 Putative ubiquinol binding site [chemical binding]; other site 393133000076 Low-spin heme (heme b) binding site [chemical binding]; other site 393133000077 Putative water exit pathway; other site 393133000078 Binuclear center (heme o3/CuB) [ion binding]; other site 393133000079 K-pathway; other site 393133000080 Putative proton exit pathway; other site 393133000081 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 393133000082 Subunit I/III interface [polypeptide binding]; other site 393133000083 Subunit III/IV interface [polypeptide binding]; other site 393133000084 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 393133000085 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 393133000086 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 393133000087 putative active site [active] 393133000088 putative metal binding site [ion binding]; other site 393133000089 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 393133000090 beta-galactosidase; Region: BGL; TIGR03356 393133000091 Bacterial SH3 domain; Region: SH3_3; pfam08239 393133000092 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 393133000093 putative active site [active] 393133000094 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133000095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133000096 DNA-binding site [nucleotide binding]; DNA binding site 393133000097 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393133000098 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133000099 active site 393133000100 active pocket/dimerization site; other site 393133000101 phosphorylation site [posttranslational modification] 393133000102 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393133000103 active site 393133000104 phosphorylation site [posttranslational modification] 393133000105 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 393133000106 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 393133000107 hypothetical protein; Provisional; Region: PRK02947 393133000108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133000109 putative active site [active] 393133000110 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 393133000111 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 393133000112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133000113 active site turn [active] 393133000114 phosphorylation site [posttranslational modification] 393133000115 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133000116 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393133000117 HPr interaction site; other site 393133000118 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133000119 active site 393133000120 phosphorylation site [posttranslational modification] 393133000121 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 393133000122 putative dimer interface [polypeptide binding]; other site 393133000123 catalytic triad [active] 393133000124 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133000125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000126 active site 393133000127 motif I; other site 393133000128 motif II; other site 393133000129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133000131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133000132 DNA binding site [nucleotide binding] 393133000133 domain linker motif; other site 393133000134 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 393133000135 dimerization interface [polypeptide binding]; other site 393133000136 putative ligand binding site [chemical binding]; other site 393133000137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133000138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133000139 nucleotide binding site [chemical binding]; other site 393133000140 Butyrate kinase [Energy production and conversion]; Region: COG3426 393133000141 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 393133000142 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 393133000143 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133000144 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133000145 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393133000146 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393133000147 dimer interface [polypeptide binding]; other site 393133000148 active site 393133000149 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393133000150 dimer interface [polypeptide binding]; other site 393133000151 active site 393133000152 putrescine carbamoyltransferase; Provisional; Region: PRK02255 393133000153 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393133000154 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393133000155 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 393133000156 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 393133000157 agmatine deiminase; Provisional; Region: PRK13551 393133000158 agmatine deiminase; Region: agmatine_aguA; TIGR03380 393133000159 carbamate kinase; Reviewed; Region: PRK12686 393133000160 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 393133000161 putative substrate binding site [chemical binding]; other site 393133000162 nucleotide binding site [chemical binding]; other site 393133000163 nucleotide binding site [chemical binding]; other site 393133000164 homodimer interface [polypeptide binding]; other site 393133000165 agmatine deiminase; Provisional; Region: PRK13551 393133000166 agmatine deiminase; Region: agmatine_aguA; TIGR03380 393133000167 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133000168 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133000169 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133000170 putative active site [active] 393133000171 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 393133000172 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393133000173 arginine deiminase; Provisional; Region: PRK01388 393133000174 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 393133000175 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 393133000176 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 393133000177 dimer interface [polypeptide binding]; other site 393133000178 ssDNA binding site [nucleotide binding]; other site 393133000179 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133000180 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 393133000181 Predicted membrane protein [Function unknown]; Region: COG3212 393133000182 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393133000183 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393133000184 putative accessory gene regulator protein; Provisional; Region: PRK01100 393133000185 Staphylococcal AgrD protein; Region: AgrD; cl05477 393133000186 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 393133000187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133000188 ATP binding site [chemical binding]; other site 393133000189 Mg2+ binding site [ion binding]; other site 393133000190 G-X-G motif; other site 393133000191 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 393133000192 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 393133000193 DHH family; Region: DHH; pfam01368 393133000194 DHHA1 domain; Region: DHHA1; pfam02272 393133000195 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 393133000196 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 393133000197 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 393133000198 replicative DNA helicase; Provisional; Region: PRK05748 393133000199 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 393133000200 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 393133000201 Walker A motif; other site 393133000202 ATP binding site [chemical binding]; other site 393133000203 Walker B motif; other site 393133000204 DNA binding loops [nucleotide binding] 393133000205 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 393133000206 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 393133000207 GDP-binding site [chemical binding]; other site 393133000208 ACT binding site; other site 393133000209 IMP binding site; other site 393133000210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 393133000211 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393133000212 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 393133000213 Predicted membrane protein [Function unknown]; Region: COG1511 393133000214 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 393133000215 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 393133000216 Uncharacterized small protein [Function unknown]; Region: COG5417 393133000217 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 393133000218 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 393133000219 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 393133000220 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 393133000221 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393133000222 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393133000223 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 393133000224 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 393133000225 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 393133000226 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 393133000227 tetramer interface [polypeptide binding]; other site 393133000228 active site 393133000229 Mg2+/Mn2+ binding site [ion binding]; other site 393133000230 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 393133000231 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 393133000232 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393133000233 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393133000234 DNA binding site [nucleotide binding] 393133000235 active site 393133000236 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 393133000237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 393133000238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 393133000239 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 393133000240 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 393133000241 putative ligand binding site [chemical binding]; other site 393133000242 putative NAD binding site [chemical binding]; other site 393133000243 catalytic site [active] 393133000244 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 393133000245 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133000246 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133000247 DNA binding residues [nucleotide binding] 393133000248 putative dimer interface [polypeptide binding]; other site 393133000249 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133000250 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133000251 active site 393133000252 catalytic tetrad [active] 393133000253 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000254 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133000255 ATP synthase subunit C; Region: ATP-synt_C; cl00466 393133000256 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 393133000257 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 393133000258 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393133000259 Walker A motif; other site 393133000260 ATP binding site [chemical binding]; other site 393133000261 Walker B motif; other site 393133000262 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393133000263 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 393133000264 core domain interface [polypeptide binding]; other site 393133000265 delta subunit interface [polypeptide binding]; other site 393133000266 epsilon subunit interface [polypeptide binding]; other site 393133000267 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 393133000268 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393133000269 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 393133000270 alpha subunit interaction interface [polypeptide binding]; other site 393133000271 Walker A motif; other site 393133000272 ATP binding site [chemical binding]; other site 393133000273 Walker B motif; other site 393133000274 inhibitor binding site; inhibition site 393133000275 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393133000276 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 393133000277 gamma subunit interface [polypeptide binding]; other site 393133000278 epsilon subunit interface [polypeptide binding]; other site 393133000279 LBP interface [polypeptide binding]; other site 393133000280 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000281 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 393133000282 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133000283 active pocket/dimerization site; other site 393133000284 active site 393133000285 phosphorylation site [posttranslational modification] 393133000286 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393133000287 active site 393133000288 phosphorylation site [posttranslational modification] 393133000289 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 393133000290 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 393133000291 Domain of unknown function (DUF956); Region: DUF956; pfam06115 393133000292 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 393133000293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133000294 dimerization interface [polypeptide binding]; other site 393133000295 putative DNA binding site [nucleotide binding]; other site 393133000296 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393133000297 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 393133000298 dimer interface [polypeptide binding]; other site 393133000299 FMN binding site [chemical binding]; other site 393133000300 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 393133000301 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 393133000302 active site 393133000303 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 393133000304 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 393133000305 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393133000306 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393133000307 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133000308 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133000309 nucleotide binding site [chemical binding]; other site 393133000310 butyrate kinase; Region: butyr_kinase; TIGR02707 393133000311 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133000312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133000313 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393133000314 Walker A/P-loop; other site 393133000315 ATP binding site [chemical binding]; other site 393133000316 Q-loop/lid; other site 393133000317 ABC transporter signature motif; other site 393133000318 Walker B; other site 393133000319 D-loop; other site 393133000320 H-loop/switch region; other site 393133000321 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133000322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133000323 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393133000324 Walker A/P-loop; other site 393133000325 ATP binding site [chemical binding]; other site 393133000326 Q-loop/lid; other site 393133000327 ABC transporter signature motif; other site 393133000328 Walker B; other site 393133000329 D-loop; other site 393133000330 H-loop/switch region; other site 393133000331 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 393133000332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133000333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133000334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133000335 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 393133000336 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393133000337 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393133000338 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000339 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393133000340 ligand binding site [chemical binding]; other site 393133000341 flexible hinge region; other site 393133000342 Domain of unknown function (DUF955); Region: DUF955; pfam06114 393133000343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133000344 non-specific DNA binding site [nucleotide binding]; other site 393133000345 salt bridge; other site 393133000346 sequence-specific DNA binding site [nucleotide binding]; other site 393133000347 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 393133000348 Predicted secreted protein [Function unknown]; Region: COG5437 393133000349 Phage-related protein [Function unknown]; Region: COG5412 393133000350 Phage tail protein; Region: Sipho_tail; pfam05709 393133000351 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 393133000352 Predicted membrane protein [Function unknown]; Region: COG1511 393133000353 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 393133000354 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 393133000355 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 393133000356 active site 393133000357 metal binding site [ion binding]; metal-binding site 393133000358 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 393133000359 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 393133000360 putative active site [active] 393133000361 putative metal binding site [ion binding]; other site 393133000362 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 393133000363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393133000364 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 393133000365 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393133000366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 393133000367 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 393133000368 active site 393133000369 Uncharacterized conserved protein [Function unknown]; Region: COG3592 393133000370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133000371 Coenzyme A binding pocket [chemical binding]; other site 393133000372 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 393133000373 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 393133000374 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393133000375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000376 dimer interface [polypeptide binding]; other site 393133000377 conserved gate region; other site 393133000378 putative PBP binding loops; other site 393133000379 ABC-ATPase subunit interface; other site 393133000380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393133000381 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 393133000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000383 dimer interface [polypeptide binding]; other site 393133000384 conserved gate region; other site 393133000385 putative PBP binding loops; other site 393133000386 ABC-ATPase subunit interface; other site 393133000387 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 393133000388 LXG domain of WXG superfamily; Region: LXG; pfam04740 393133000389 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 393133000390 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393133000391 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393133000392 peptide binding site [polypeptide binding]; other site 393133000393 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393133000394 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 393133000395 metal binding site [ion binding]; metal-binding site 393133000396 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 393133000397 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393133000398 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393133000399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133000400 ABC-ATPase subunit interface; other site 393133000401 dimer interface [polypeptide binding]; other site 393133000402 putative PBP binding regions; other site 393133000403 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000404 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133000405 ligand binding site [chemical binding]; other site 393133000406 flexible hinge region; other site 393133000407 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 393133000408 DEAD_2; Region: DEAD_2; pfam06733 393133000409 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 393133000410 sugar phosphate phosphatase; Provisional; Region: PRK10513 393133000411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000412 active site 393133000413 motif I; other site 393133000414 motif II; other site 393133000415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000416 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393133000417 Collagen binding domain; Region: Collagen_bind; pfam05737 393133000418 Cna protein B-type domain; Region: Cna_B; pfam05738 393133000419 Cna protein B-type domain; Region: Cna_B; pfam05738 393133000420 Cna protein B-type domain; Region: Cna_B; pfam05738 393133000421 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393133000422 Collagen binding domain; Region: Collagen_bind; pfam05737 393133000423 Cna protein B-type domain; Region: Cna_B; pfam05738 393133000424 Cna protein B-type domain; Region: Cna_B; pfam05738 393133000425 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133000426 DNA polymerase III subunit delta'; Validated; Region: PRK08058 393133000427 DNA polymerase III subunit delta'; Validated; Region: PRK08485 393133000428 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 393133000429 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 393133000430 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 393133000431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133000432 S-adenosylmethionine binding site [chemical binding]; other site 393133000433 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 393133000434 GIY-YIG motif/motif A; other site 393133000435 putative active site [active] 393133000436 putative metal binding site [ion binding]; other site 393133000437 Predicted methyltransferases [General function prediction only]; Region: COG0313 393133000438 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 393133000439 putative SAM binding site [chemical binding]; other site 393133000440 putative homodimer interface [polypeptide binding]; other site 393133000441 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 393133000442 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 393133000443 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393133000444 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393133000445 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393133000446 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 393133000447 Leucine rich repeat; Region: LRR_8; pfam13855 393133000448 LRR adjacent; Region: LRR_adjacent; pfam08191 393133000449 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133000450 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133000451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393133000452 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393133000453 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133000454 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393133000455 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 393133000456 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 393133000457 active site 393133000458 HIGH motif; other site 393133000459 KMSKS motif; other site 393133000460 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 393133000461 tRNA binding surface [nucleotide binding]; other site 393133000462 anticodon binding site; other site 393133000463 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 393133000464 dimer interface [polypeptide binding]; other site 393133000465 putative tRNA-binding site [nucleotide binding]; other site 393133000466 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 393133000467 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133000468 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393133000469 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393133000470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000471 dimer interface [polypeptide binding]; other site 393133000472 conserved gate region; other site 393133000473 putative PBP binding loops; other site 393133000474 ABC-ATPase subunit interface; other site 393133000475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133000476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000477 dimer interface [polypeptide binding]; other site 393133000478 conserved gate region; other site 393133000479 putative PBP binding loops; other site 393133000480 ABC-ATPase subunit interface; other site 393133000481 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393133000482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133000483 alpha-glucosidase; Provisional; Region: PRK10426 393133000484 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393133000485 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 393133000486 active site 393133000487 catalytic site [active] 393133000488 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393133000489 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393133000490 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 393133000491 trimer interface [polypeptide binding]; other site 393133000492 active site 393133000493 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 393133000494 catalytic site [active] 393133000495 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393133000496 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393133000497 Ca binding site [ion binding]; other site 393133000498 active site 393133000499 catalytic site [active] 393133000500 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 393133000501 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 393133000502 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 393133000503 active site 393133000504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 393133000505 Domain of unknown function (DUF348); Region: DUF348; pfam03990 393133000506 Domain of unknown function (DUF348); Region: DUF348; pfam03990 393133000507 G5 domain; Region: G5; pfam07501 393133000508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 393133000509 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 393133000510 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 393133000511 putative active site [active] 393133000512 putative metal binding site [ion binding]; other site 393133000513 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 393133000514 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 393133000515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133000516 S-adenosylmethionine binding site [chemical binding]; other site 393133000517 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 393133000518 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 393133000519 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393133000520 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 393133000521 putative active site [active] 393133000522 YdjC motif; other site 393133000523 Mg binding site [ion binding]; other site 393133000524 putative homodimer interface [polypeptide binding]; other site 393133000525 pur operon repressor; Provisional; Region: PRK09213 393133000526 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 393133000527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133000528 active site 393133000529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 393133000530 HlyD family secretion protein; Region: HlyD_3; pfam13437 393133000531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133000532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133000533 Walker A/P-loop; other site 393133000534 ATP binding site [chemical binding]; other site 393133000535 Q-loop/lid; other site 393133000536 ABC transporter signature motif; other site 393133000537 Walker B; other site 393133000538 D-loop; other site 393133000539 H-loop/switch region; other site 393133000540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133000541 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393133000542 FtsX-like permease family; Region: FtsX; pfam02687 393133000543 regulatory protein SpoVG; Reviewed; Region: PRK13259 393133000544 regulatory protein SpoVG; Reviewed; Region: PRK13259 393133000545 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 393133000546 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 393133000547 Substrate binding site; other site 393133000548 Mg++ binding site; other site 393133000549 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 393133000550 active site 393133000551 substrate binding site [chemical binding]; other site 393133000552 CoA binding site [chemical binding]; other site 393133000553 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 393133000554 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 393133000555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133000556 active site 393133000557 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000558 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133000559 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133000560 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 393133000561 active site 393133000562 catalytic site [active] 393133000563 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 393133000564 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 393133000565 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 393133000566 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393133000567 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 393133000568 active site 393133000569 Zn binding site [ion binding]; other site 393133000570 ActA Protein; Region: ActA; pfam05058 393133000571 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 393133000572 Zn binding site [ion binding]; other site 393133000573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 393133000574 hypothetical protein; Provisional; Region: PRK01119 393133000575 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 393133000576 A new structural DNA glycosylase; Region: AlkD_like; cd06561 393133000577 active site 393133000578 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 393133000579 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393133000580 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133000581 NAD binding site [chemical binding]; other site 393133000582 dimer interface [polypeptide binding]; other site 393133000583 substrate binding site [chemical binding]; other site 393133000584 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 393133000585 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 393133000586 5S rRNA interface [nucleotide binding]; other site 393133000587 CTC domain interface [polypeptide binding]; other site 393133000588 L16 interface [polypeptide binding]; other site 393133000589 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133000590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133000591 Coenzyme A binding pocket [chemical binding]; other site 393133000592 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 393133000593 putative active site [active] 393133000594 catalytic residue [active] 393133000595 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 393133000596 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 393133000597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133000598 ATP binding site [chemical binding]; other site 393133000599 putative Mg++ binding site [ion binding]; other site 393133000600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133000601 nucleotide binding region [chemical binding]; other site 393133000602 ATP-binding site [chemical binding]; other site 393133000603 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 393133000604 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393133000605 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393133000606 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133000607 RNA binding surface [nucleotide binding]; other site 393133000608 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 393133000609 Septum formation initiator; Region: DivIC; pfam04977 393133000610 hypothetical protein; Provisional; Region: PRK08582 393133000611 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393133000612 RNA binding site [nucleotide binding]; other site 393133000613 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 393133000614 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 393133000615 Ligand Binding Site [chemical binding]; other site 393133000616 TilS substrate C-terminal domain; Region: TilS_C; smart00977 393133000617 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 393133000618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133000619 active site 393133000620 FtsH Extracellular; Region: FtsH_ext; pfam06480 393133000621 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 393133000622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133000623 Walker A motif; other site 393133000624 ATP binding site [chemical binding]; other site 393133000625 Walker B motif; other site 393133000626 arginine finger; other site 393133000627 Peptidase family M41; Region: Peptidase_M41; pfam01434 393133000628 pantothenate kinase; Reviewed; Region: PRK13318 393133000629 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 393133000630 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 393133000631 dimerization interface [polypeptide binding]; other site 393133000632 domain crossover interface; other site 393133000633 redox-dependent activation switch; other site 393133000634 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 393133000635 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 393133000636 dimer interface [polypeptide binding]; other site 393133000637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133000638 catalytic residue [active] 393133000639 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 393133000640 homooctamer interface [polypeptide binding]; other site 393133000641 active site 393133000642 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 393133000643 catalytic center binding site [active] 393133000644 ATP binding site [chemical binding]; other site 393133000645 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 393133000646 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 393133000647 FMN binding site [chemical binding]; other site 393133000648 active site 393133000649 catalytic residues [active] 393133000650 substrate binding site [chemical binding]; other site 393133000651 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 393133000652 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 393133000653 dimer interface [polypeptide binding]; other site 393133000654 putative anticodon binding site; other site 393133000655 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 393133000656 motif 1; other site 393133000657 active site 393133000658 motif 2; other site 393133000659 motif 3; other site 393133000660 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 393133000661 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 393133000662 UvrB/uvrC motif; Region: UVR; pfam02151 393133000663 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 393133000664 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 393133000665 ADP binding site [chemical binding]; other site 393133000666 phosphagen binding site; other site 393133000667 substrate specificity loop; other site 393133000668 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 393133000669 Clp amino terminal domain; Region: Clp_N; pfam02861 393133000670 Clp amino terminal domain; Region: Clp_N; pfam02861 393133000671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133000672 Walker A motif; other site 393133000673 ATP binding site [chemical binding]; other site 393133000674 Walker B motif; other site 393133000675 arginine finger; other site 393133000676 UvrB/uvrC motif; Region: UVR; pfam02151 393133000677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133000678 Walker A motif; other site 393133000679 ATP binding site [chemical binding]; other site 393133000680 Walker B motif; other site 393133000681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393133000682 DNA repair protein RadA; Provisional; Region: PRK11823 393133000683 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 393133000684 Walker A motif/ATP binding site; other site 393133000685 ATP binding site [chemical binding]; other site 393133000686 Walker B motif; other site 393133000687 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 393133000688 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 393133000689 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 393133000690 putative active site [active] 393133000691 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 393133000692 substrate binding site; other site 393133000693 dimer interface; other site 393133000694 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 393133000695 homotrimer interaction site [polypeptide binding]; other site 393133000696 zinc binding site [ion binding]; other site 393133000697 CDP-binding sites; other site 393133000698 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 393133000699 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393133000700 HIGH motif; other site 393133000701 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393133000702 active site 393133000703 KMSKS motif; other site 393133000704 serine O-acetyltransferase; Region: cysE; TIGR01172 393133000705 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 393133000706 trimer interface [polypeptide binding]; other site 393133000707 active site 393133000708 substrate binding site [chemical binding]; other site 393133000709 CoA binding site [chemical binding]; other site 393133000710 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 393133000711 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393133000712 active site 393133000713 HIGH motif; other site 393133000714 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393133000715 KMSKS motif; other site 393133000716 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 393133000717 tRNA binding surface [nucleotide binding]; other site 393133000718 anticodon binding site; other site 393133000719 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 393133000720 active site 393133000721 metal binding site [ion binding]; metal-binding site 393133000722 dimerization interface [polypeptide binding]; other site 393133000723 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 393133000724 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 393133000725 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393133000726 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 393133000727 RNA polymerase factor sigma-70; Validated; Region: PRK08295 393133000728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393133000729 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 393133000730 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 393133000731 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 393133000732 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 393133000733 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 393133000734 putative homodimer interface [polypeptide binding]; other site 393133000735 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 393133000736 heterodimer interface [polypeptide binding]; other site 393133000737 homodimer interface [polypeptide binding]; other site 393133000738 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 393133000739 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 393133000740 23S rRNA interface [nucleotide binding]; other site 393133000741 L7/L12 interface [polypeptide binding]; other site 393133000742 putative thiostrepton binding site; other site 393133000743 L25 interface [polypeptide binding]; other site 393133000744 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 393133000745 mRNA/rRNA interface [nucleotide binding]; other site 393133000746 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 393133000747 23S rRNA interface [nucleotide binding]; other site 393133000748 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 393133000749 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 393133000750 core dimer interface [polypeptide binding]; other site 393133000751 peripheral dimer interface [polypeptide binding]; other site 393133000752 L10 interface [polypeptide binding]; other site 393133000753 L11 interface [polypeptide binding]; other site 393133000754 putative EF-Tu interaction site [polypeptide binding]; other site 393133000755 putative EF-G interaction site [polypeptide binding]; other site 393133000756 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 393133000757 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393133000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133000759 S-adenosylmethionine binding site [chemical binding]; other site 393133000760 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 393133000761 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 393133000762 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393133000763 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393133000764 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 393133000765 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393133000766 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 393133000767 RPB10 interaction site [polypeptide binding]; other site 393133000768 RPB1 interaction site [polypeptide binding]; other site 393133000769 RPB11 interaction site [polypeptide binding]; other site 393133000770 RPB3 interaction site [polypeptide binding]; other site 393133000771 RPB12 interaction site [polypeptide binding]; other site 393133000772 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 393133000773 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 393133000774 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 393133000775 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 393133000776 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 393133000777 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 393133000778 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 393133000779 G-loop; other site 393133000780 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 393133000781 DNA binding site [nucleotide binding] 393133000782 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 393133000783 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 393133000784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000785 active site 393133000786 motif I; other site 393133000787 motif II; other site 393133000788 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133000789 beta-galactosidase; Region: BGL; TIGR03356 393133000790 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133000791 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133000792 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000793 Substrate binding site [chemical binding]; other site 393133000794 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000795 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000796 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000797 LRR adjacent; Region: LRR_adjacent; pfam08191 393133000798 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000799 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000800 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133000801 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133000802 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133000803 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000804 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000805 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000806 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000807 LRR adjacent; Region: LRR_adjacent; pfam08191 393133000808 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000809 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000810 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133000811 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133000812 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000813 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000814 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000815 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000817 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000818 LRR adjacent; Region: LRR_adjacent; pfam08191 393133000819 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000820 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000821 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133000822 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000823 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000824 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133000828 LRR adjacent; Region: LRR_adjacent; pfam08191 393133000829 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133000830 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133000831 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 393133000832 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 393133000833 metal binding site [ion binding]; metal-binding site 393133000834 dimer interface [polypeptide binding]; other site 393133000835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133000836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133000837 putative Zn2+ binding site [ion binding]; other site 393133000838 putative DNA binding site [nucleotide binding]; other site 393133000839 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393133000840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133000841 Zn binding site [ion binding]; other site 393133000842 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393133000843 Zn binding site [ion binding]; other site 393133000844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133000845 catalytic core [active] 393133000846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393133000847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000848 dimer interface [polypeptide binding]; other site 393133000849 conserved gate region; other site 393133000850 putative PBP binding loops; other site 393133000851 ABC-ATPase subunit interface; other site 393133000852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393133000853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000854 dimer interface [polypeptide binding]; other site 393133000855 conserved gate region; other site 393133000856 ABC-ATPase subunit interface; other site 393133000857 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 393133000858 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133000859 beta-galactosidase; Region: BGL; TIGR03356 393133000860 sugar phosphate phosphatase; Provisional; Region: PRK10513 393133000861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000862 active site 393133000863 motif I; other site 393133000864 motif II; other site 393133000865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133000867 Coenzyme A binding pocket [chemical binding]; other site 393133000868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000869 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133000870 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 393133000871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393133000872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000873 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 393133000874 active site 393133000875 motif I; other site 393133000876 motif II; other site 393133000877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133000878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133000879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133000880 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393133000881 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 393133000882 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 393133000883 Walker A/P-loop; other site 393133000884 ATP binding site [chemical binding]; other site 393133000885 Q-loop/lid; other site 393133000886 ABC transporter signature motif; other site 393133000887 Walker B; other site 393133000888 D-loop; other site 393133000889 H-loop/switch region; other site 393133000890 TOBE domain; Region: TOBE; pfam03459 393133000891 ATP cone domain; Region: ATP-cone; pfam03477 393133000892 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 393133000893 Class III ribonucleotide reductase; Region: RNR_III; cd01675 393133000894 effector binding site; other site 393133000895 active site 393133000896 Zn binding site [ion binding]; other site 393133000897 glycine loop; other site 393133000898 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 393133000899 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 393133000900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133000901 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393133000902 Walker A/P-loop; other site 393133000903 ATP binding site [chemical binding]; other site 393133000904 Q-loop/lid; other site 393133000905 ABC transporter signature motif; other site 393133000906 Walker B; other site 393133000907 D-loop; other site 393133000908 H-loop/switch region; other site 393133000909 CitB domain protein; Region: CitB; TIGR02484 393133000910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133000911 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133000912 ligand binding site [chemical binding]; other site 393133000913 flexible hinge region; other site 393133000914 Predicted amidohydrolase [General function prediction only]; Region: COG0388 393133000915 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 393133000916 putative active site [active] 393133000917 catalytic triad [active] 393133000918 putative dimer interface [polypeptide binding]; other site 393133000919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133000920 dimer interface [polypeptide binding]; other site 393133000921 conserved gate region; other site 393133000922 ABC-ATPase subunit interface; other site 393133000923 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 393133000924 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 393133000925 Walker A/P-loop; other site 393133000926 ATP binding site [chemical binding]; other site 393133000927 Q-loop/lid; other site 393133000928 ABC transporter signature motif; other site 393133000929 Walker B; other site 393133000930 D-loop; other site 393133000931 H-loop/switch region; other site 393133000932 NIL domain; Region: NIL; pfam09383 393133000933 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 393133000934 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 393133000935 transaminase; Reviewed; Region: PRK08068 393133000936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133000937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133000938 homodimer interface [polypeptide binding]; other site 393133000939 catalytic residue [active] 393133000940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133000941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133000942 active site 393133000943 phosphorylation site [posttranslational modification] 393133000944 intermolecular recognition site; other site 393133000945 dimerization interface [polypeptide binding]; other site 393133000946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133000947 DNA binding site [nucleotide binding] 393133000948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 393133000949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133000950 dimerization interface [polypeptide binding]; other site 393133000951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393133000952 putative active site [active] 393133000953 heme pocket [chemical binding]; other site 393133000954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133000955 dimer interface [polypeptide binding]; other site 393133000956 phosphorylation site [posttranslational modification] 393133000957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133000958 ATP binding site [chemical binding]; other site 393133000959 Mg2+ binding site [ion binding]; other site 393133000960 G-X-G motif; other site 393133000961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 393133000962 YycH protein; Region: YycH; pfam07435 393133000963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 393133000964 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 393133000965 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 393133000966 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 393133000967 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 393133000968 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 393133000969 protein binding site [polypeptide binding]; other site 393133000970 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 393133000971 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 393133000972 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 393133000973 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 393133000974 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 393133000975 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 393133000976 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 393133000977 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 393133000978 ATP binding site [chemical binding]; other site 393133000979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393133000980 putative Mg++ binding site [ion binding]; other site 393133000981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133000982 Coenzyme A binding pocket [chemical binding]; other site 393133000983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133000984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133000985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393133000986 dimerization interface [polypeptide binding]; other site 393133000987 Protein of unknown function (DUF998); Region: DUF998; pfam06197 393133000988 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133000989 HTH domain; Region: HTH_11; pfam08279 393133000990 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133000991 PRD domain; Region: PRD; pfam00874 393133000992 PRD domain; Region: PRD; pfam00874 393133000993 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133000994 active site 393133000995 P-loop; other site 393133000996 phosphorylation site [posttranslational modification] 393133000997 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133000998 active site 393133000999 phosphorylation site [posttranslational modification] 393133001000 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133001001 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133001002 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133001003 active site 393133001004 P-loop; other site 393133001005 phosphorylation site [posttranslational modification] 393133001006 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133001007 beta-galactosidase; Region: BGL; TIGR03356 393133001008 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133001009 methionine cluster; other site 393133001010 active site 393133001011 phosphorylation site [posttranslational modification] 393133001012 metal binding site [ion binding]; metal-binding site 393133001013 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 393133001014 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 393133001015 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 393133001016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 393133001017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393133001018 catalytic residue [active] 393133001019 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 393133001020 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 393133001021 nucleophilic elbow; other site 393133001022 catalytic triad; other site 393133001023 Uncharacterized conserved protein [Function unknown]; Region: COG1479 393133001024 Protein of unknown function DUF262; Region: DUF262; pfam03235 393133001025 Protein of unknown function DUF262; Region: DUF262; pfam03235 393133001026 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 393133001027 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393133001028 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 393133001029 putative active site [active] 393133001030 YdjC motif; other site 393133001031 Mg binding site [ion binding]; other site 393133001032 putative homodimer interface [polypeptide binding]; other site 393133001033 Putative transcription activator [Transcription]; Region: TenA; COG0819 393133001034 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 393133001035 substrate binding site [chemical binding]; other site 393133001036 multimerization interface [polypeptide binding]; other site 393133001037 ATP binding site [chemical binding]; other site 393133001038 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 393133001039 dimer interface [polypeptide binding]; other site 393133001040 substrate binding site [chemical binding]; other site 393133001041 ATP binding site [chemical binding]; other site 393133001042 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 393133001043 thiamine phosphate binding site [chemical binding]; other site 393133001044 active site 393133001045 pyrophosphate binding site [ion binding]; other site 393133001046 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133001047 beta-galactosidase; Region: BGL; TIGR03356 393133001048 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 393133001049 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 393133001050 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 393133001051 putative catalytic site [active] 393133001052 putative metal binding site [ion binding]; other site 393133001053 putative phosphate binding site [ion binding]; other site 393133001054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133001055 non-specific DNA binding site [nucleotide binding]; other site 393133001056 salt bridge; other site 393133001057 sequence-specific DNA binding site [nucleotide binding]; other site 393133001058 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393133001059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133001060 non-specific DNA binding site [nucleotide binding]; other site 393133001061 salt bridge; other site 393133001062 sequence-specific DNA binding site [nucleotide binding]; other site 393133001063 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393133001064 Leucine rich repeat; Region: LRR_8; pfam13855 393133001065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001067 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001068 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001069 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001070 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001071 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001072 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001073 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001074 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001075 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001076 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001077 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001078 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001079 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001080 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133001081 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001082 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133001083 Leucine-rich repeats; other site 393133001084 Substrate binding site [chemical binding]; other site 393133001085 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001086 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001087 Leucine rich repeat; Region: LRR_8; pfam13855 393133001088 Leucine rich repeat; Region: LRR_8; pfam13855 393133001089 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001090 Leucine rich repeat; Region: LRR_8; pfam13855 393133001091 Leucine rich repeat; Region: LRR_8; pfam13855 393133001092 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001093 LRR adjacent; Region: LRR_adjacent; pfam08191 393133001094 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001095 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001096 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001097 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 393133001098 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 393133001099 LXG domain of WXG superfamily; Region: LXG; pfam04740 393133001100 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 393133001101 Enterocin A Immunity; Region: EntA_Immun; pfam08951 393133001102 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393133001103 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393133001104 TPP-binding site [chemical binding]; other site 393133001105 dimer interface [polypeptide binding]; other site 393133001106 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393133001107 PYR/PP interface [polypeptide binding]; other site 393133001108 dimer interface [polypeptide binding]; other site 393133001109 TPP binding site [chemical binding]; other site 393133001110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133001111 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 393133001112 active site 393133001113 intersubunit interactions; other site 393133001114 catalytic residue [active] 393133001115 short chain dehydrogenase; Provisional; Region: PRK06841 393133001116 classical (c) SDRs; Region: SDR_c; cd05233 393133001117 NAD(P) binding site [chemical binding]; other site 393133001118 active site 393133001119 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393133001120 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 393133001121 substrate binding site [chemical binding]; other site 393133001122 dimer interface [polypeptide binding]; other site 393133001123 catalytic triad [active] 393133001124 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393133001125 DAK2 domain; Region: Dak2; cl03685 393133001126 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 393133001127 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393133001128 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 393133001129 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133001130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133001131 putative DNA binding site [nucleotide binding]; other site 393133001132 putative Zn2+ binding site [ion binding]; other site 393133001133 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133001134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133001135 Coenzyme A binding pocket [chemical binding]; other site 393133001136 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 393133001137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393133001138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393133001139 acyl-activating enzyme (AAE) consensus motif; other site 393133001140 acyl-activating enzyme (AAE) consensus motif; other site 393133001141 AMP binding site [chemical binding]; other site 393133001142 active site 393133001143 CoA binding site [chemical binding]; other site 393133001144 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 393133001145 L-aspartate oxidase; Provisional; Region: PRK06175 393133001146 putative oxidoreductase; Provisional; Region: PRK10206 393133001147 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133001148 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393133001149 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001150 active site 393133001151 phosphorylation site [posttranslational modification] 393133001152 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 393133001153 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133001154 active site 393133001155 P-loop; other site 393133001156 phosphorylation site [posttranslational modification] 393133001157 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133001158 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393133001159 intersubunit interface [polypeptide binding]; other site 393133001160 active site 393133001161 zinc binding site [ion binding]; other site 393133001162 Na+ binding site [ion binding]; other site 393133001163 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133001164 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 393133001165 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133001166 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 393133001167 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 393133001168 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 393133001169 conserved cys residue [active] 393133001170 Predicted transcriptional regulator [Transcription]; Region: COG2378 393133001171 HTH domain; Region: HTH_11; pfam08279 393133001172 WYL domain; Region: WYL; pfam13280 393133001173 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 393133001174 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 393133001175 Imelysin; Region: Peptidase_M75; pfam09375 393133001176 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 393133001177 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 393133001178 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 393133001179 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 393133001180 nudix motif; other site 393133001181 hypothetical protein; Provisional; Region: PRK12378 393133001182 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 393133001183 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 393133001184 PhnA protein; Region: PhnA; pfam03831 393133001185 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133001186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133001187 DNA-binding site [nucleotide binding]; DNA binding site 393133001188 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393133001189 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133001190 beta-galactosidase; Region: BGL; TIGR03356 393133001191 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133001192 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 393133001193 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133001194 active site 393133001195 P-loop; other site 393133001196 phosphorylation site [posttranslational modification] 393133001197 Predicted transcriptional regulator [Transcription]; Region: COG2378 393133001198 HTH domain; Region: HTH_11; pfam08279 393133001199 WYL domain; Region: WYL; pfam13280 393133001200 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133001201 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 393133001202 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133001203 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 393133001204 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 393133001205 tetrameric interface [polypeptide binding]; other site 393133001206 NAD binding site [chemical binding]; other site 393133001207 catalytic residues [active] 393133001208 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 393133001209 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 393133001210 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 393133001211 substrate binding site [chemical binding]; other site 393133001212 ATP binding site [chemical binding]; other site 393133001213 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 393133001214 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393133001215 PYR/PP interface [polypeptide binding]; other site 393133001216 dimer interface [polypeptide binding]; other site 393133001217 TPP binding site [chemical binding]; other site 393133001218 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393133001219 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 393133001220 TPP-binding site; other site 393133001221 Uncharacterized conserved protein [Function unknown]; Region: COG5646 393133001222 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 393133001223 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 393133001224 ligand binding site [chemical binding]; other site 393133001225 active site 393133001226 UGI interface [polypeptide binding]; other site 393133001227 catalytic site [active] 393133001228 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 393133001229 hypothetical protein; Provisional; Region: PRK13665 393133001230 NlpC/P60 family; Region: NLPC_P60; pfam00877 393133001231 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133001232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133001233 Coenzyme A binding pocket [chemical binding]; other site 393133001234 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 393133001235 pyrroline-5-carboxylate reductase; Region: PLN02688 393133001236 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 393133001237 putative hydrophobic ligand binding site [chemical binding]; other site 393133001238 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001239 active site 393133001240 phosphorylation site [posttranslational modification] 393133001241 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133001242 active site 393133001243 P-loop; other site 393133001244 phosphorylation site [posttranslational modification] 393133001245 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133001246 alpha-mannosidase; Provisional; Region: PRK09819 393133001247 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393133001248 active site 393133001249 metal binding site [ion binding]; metal-binding site 393133001250 catalytic site [active] 393133001251 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393133001252 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133001253 HTH domain; Region: HTH_11; pfam08279 393133001254 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133001255 PRD domain; Region: PRD; pfam00874 393133001256 PRD domain; Region: PRD; pfam00874 393133001257 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133001258 active site 393133001259 P-loop; other site 393133001260 phosphorylation site [posttranslational modification] 393133001261 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001262 active site 393133001263 phosphorylation site [posttranslational modification] 393133001264 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 393133001265 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 393133001266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133001267 putative metal binding site [ion binding]; other site 393133001268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 393133001269 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 393133001270 trimer interface [polypeptide binding]; other site 393133001271 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133001272 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 393133001273 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133001274 Leucine-rich repeats; other site 393133001275 Substrate binding site [chemical binding]; other site 393133001276 LRR adjacent; Region: LRR_adjacent; pfam08191 393133001277 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001278 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001279 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001280 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001281 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133001282 phosphoenolpyruvate synthase; Validated; Region: PRK06241 393133001283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393133001284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393133001285 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 393133001286 ZIP Zinc transporter; Region: Zip; pfam02535 393133001287 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 393133001288 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 393133001289 NodB motif; other site 393133001290 active site 393133001291 catalytic site [active] 393133001292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133001293 non-specific DNA binding site [nucleotide binding]; other site 393133001294 salt bridge; other site 393133001295 sequence-specific DNA binding site [nucleotide binding]; other site 393133001296 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 393133001297 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393133001298 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 393133001299 Predicted transcriptional regulators [Transcription]; Region: COG1695 393133001300 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 393133001301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393133001302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393133001303 DNA binding residues [nucleotide binding] 393133001304 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393133001305 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133001306 HTH domain; Region: HTH_11; pfam08279 393133001307 PRD domain; Region: PRD; pfam00874 393133001308 PRD domain; Region: PRD; pfam00874 393133001309 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133001310 active site 393133001311 P-loop; other site 393133001312 phosphorylation site [posttranslational modification] 393133001313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001314 active site 393133001315 phosphorylation site [posttranslational modification] 393133001316 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001317 active site 393133001318 phosphorylation site [posttranslational modification] 393133001319 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133001320 active site 393133001321 P-loop; other site 393133001322 phosphorylation site [posttranslational modification] 393133001323 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133001324 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393133001325 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393133001326 active site 393133001327 metal binding site [ion binding]; metal-binding site 393133001328 catalytic site [active] 393133001329 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 393133001330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133001331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133001332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393133001333 dimerization interface [polypeptide binding]; other site 393133001334 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 393133001335 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 393133001336 active site 393133001337 substrate binding site [chemical binding]; other site 393133001338 trimer interface [polypeptide binding]; other site 393133001339 CoA binding site [chemical binding]; other site 393133001340 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 393133001341 classical (c) SDRs; Region: SDR_c; cd05233 393133001342 NAD(P) binding site [chemical binding]; other site 393133001343 active site 393133001344 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133001345 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001346 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133001347 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001348 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001349 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001350 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001351 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001352 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001353 LRR adjacent; Region: LRR_adjacent; pfam08191 393133001354 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001355 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001356 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001357 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133001358 Leucine rich repeat; Region: LRR_8; pfam13855 393133001359 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133001360 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001361 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001362 LRR adjacent; Region: LRR_adjacent; pfam08191 393133001363 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393133001364 SH3-like domain; Region: SH3_8; pfam13457 393133001365 Predicted transcriptional regulator [Transcription]; Region: COG1959 393133001366 Transcriptional regulator; Region: Rrf2; pfam02082 393133001367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393133001368 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 393133001369 NAD(P) binding site [chemical binding]; other site 393133001370 active site 393133001371 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 393133001372 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 393133001373 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 393133001374 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 393133001375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393133001376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393133001377 Transcriptional regulator [Transcription]; Region: LytR; COG1316 393133001378 Predicted membrane protein [Function unknown]; Region: COG1511 393133001379 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393133001380 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 393133001381 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 393133001382 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 393133001383 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133001384 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 393133001385 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 393133001386 active site 393133001387 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393133001388 L-tyrosine decarboxylase; Provisional; Region: PRK13520 393133001389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133001390 catalytic residue [active] 393133001391 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 393133001392 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 393133001393 Predicted membrane protein [Function unknown]; Region: COG3619 393133001394 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 393133001395 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 393133001396 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 393133001397 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 393133001398 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 393133001399 Protein of unknown function DUF58; Region: DUF58; pfam01882 393133001400 MoxR-like ATPases [General function prediction only]; Region: COG0714 393133001401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133001402 Walker A motif; other site 393133001403 ATP binding site [chemical binding]; other site 393133001404 Walker B motif; other site 393133001405 arginine finger; other site 393133001406 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 393133001407 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 393133001408 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 393133001409 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 393133001410 Na binding site [ion binding]; other site 393133001411 Uncharacterized conserved protein [Function unknown]; Region: COG3535 393133001412 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 393133001413 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133001414 nucleotide binding site [chemical binding]; other site 393133001415 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 393133001416 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 393133001417 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 393133001418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133001419 Zn2+ binding site [ion binding]; other site 393133001420 Mg2+ binding site [ion binding]; other site 393133001421 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 393133001422 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 393133001423 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 393133001424 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 393133001425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133001426 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 393133001427 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 393133001428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393133001429 FeS/SAM binding site; other site 393133001430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 393133001431 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 393133001432 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 393133001433 putative FMN binding site [chemical binding]; other site 393133001434 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 393133001435 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 393133001436 nudix motif; other site 393133001437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133001438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133001439 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393133001440 putative dimerization interface [polypeptide binding]; other site 393133001441 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 393133001442 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 393133001443 active site 393133001444 FMN binding site [chemical binding]; other site 393133001445 substrate binding site [chemical binding]; other site 393133001446 putative catalytic residue [active] 393133001447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 393133001448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133001449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133001450 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 393133001451 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393133001452 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393133001453 shikimate binding site; other site 393133001454 NAD(P) binding site [chemical binding]; other site 393133001455 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 393133001456 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 393133001457 active site 393133001458 catalytic residue [active] 393133001459 dimer interface [polypeptide binding]; other site 393133001460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133001461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133001462 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 393133001463 dimerization interface [polypeptide binding]; other site 393133001464 substrate binding pocket [chemical binding]; other site 393133001465 Predicted acyl esterases [General function prediction only]; Region: COG2936 393133001466 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 393133001467 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 393133001468 active site 393133001469 catalytic triad [active] 393133001470 oxyanion hole [active] 393133001471 EamA-like transporter family; Region: EamA; pfam00892 393133001472 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 393133001473 EamA-like transporter family; Region: EamA; pfam00892 393133001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 393133001475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393133001476 active site 393133001477 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393133001478 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133001479 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133001480 substrate binding site [chemical binding]; other site 393133001481 hexamer interface [polypeptide binding]; other site 393133001482 metal binding site [ion binding]; metal-binding site 393133001483 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 393133001484 catalytic residue [active] 393133001485 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133001486 PRD domain; Region: PRD; pfam00874 393133001487 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133001488 active site 393133001489 P-loop; other site 393133001490 phosphorylation site [posttranslational modification] 393133001491 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001492 active site 393133001493 phosphorylation site [posttranslational modification] 393133001494 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 393133001495 putative active site [active] 393133001496 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001497 active site 393133001498 phosphorylation site [posttranslational modification] 393133001499 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133001500 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133001501 substrate binding site [chemical binding]; other site 393133001502 hexamer interface [polypeptide binding]; other site 393133001503 metal binding site [ion binding]; metal-binding site 393133001504 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393133001505 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 393133001506 putative NAD(P) binding site [chemical binding]; other site 393133001507 catalytic Zn binding site [ion binding]; other site 393133001508 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393133001509 active site 393133001510 P-loop; other site 393133001511 phosphorylation site [posttranslational modification] 393133001512 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393133001513 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393133001514 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 393133001515 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 393133001516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133001517 active site 393133001518 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 393133001519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 393133001520 catalytic triad [active] 393133001521 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 393133001522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133001523 MarR family; Region: MarR_2; pfam12802 393133001524 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001525 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133001526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393133001527 Ligand Binding Site [chemical binding]; other site 393133001528 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 393133001529 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 393133001530 putative active site [active] 393133001531 putative metal binding site [ion binding]; other site 393133001532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133001533 catalytic core [active] 393133001534 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133001535 Predicted membrane protein [Function unknown]; Region: COG3759 393133001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133001537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133001538 putative substrate translocation pore; other site 393133001539 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393133001540 non-specific DNA interactions [nucleotide binding]; other site 393133001541 DNA binding site [nucleotide binding] 393133001542 sequence specific DNA binding site [nucleotide binding]; other site 393133001543 putative cAMP binding site [chemical binding]; other site 393133001544 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133001545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393133001546 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 393133001547 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 393133001548 NAD binding site [chemical binding]; other site 393133001549 sugar binding site [chemical binding]; other site 393133001550 divalent metal binding site [ion binding]; other site 393133001551 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133001552 dimer interface [polypeptide binding]; other site 393133001553 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133001554 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133001555 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133001556 putative active site [active] 393133001557 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 393133001558 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 393133001559 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393133001560 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 393133001561 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393133001562 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393133001563 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 393133001564 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 393133001565 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393133001566 DNA binding residues [nucleotide binding] 393133001567 dimer interface [polypeptide binding]; other site 393133001568 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 393133001569 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 393133001570 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 393133001571 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 393133001572 DXD motif; other site 393133001573 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 393133001574 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 393133001575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393133001576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133001577 S-adenosylmethionine binding site [chemical binding]; other site 393133001578 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 393133001579 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 393133001580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133001581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133001582 DNA binding site [nucleotide binding] 393133001583 domain linker motif; other site 393133001584 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 393133001585 putative dimerization interface [polypeptide binding]; other site 393133001586 putative ligand binding site [chemical binding]; other site 393133001587 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 393133001588 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 393133001589 NAD binding site [chemical binding]; other site 393133001590 sugar binding site [chemical binding]; other site 393133001591 divalent metal binding site [ion binding]; other site 393133001592 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133001593 dimer interface [polypeptide binding]; other site 393133001594 allantoate amidohydrolase; Reviewed; Region: PRK09290 393133001595 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 393133001596 active site 393133001597 metal binding site [ion binding]; metal-binding site 393133001598 dimer interface [polypeptide binding]; other site 393133001599 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393133001600 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 393133001601 metal binding site [ion binding]; metal-binding site 393133001602 putative dimer interface [polypeptide binding]; other site 393133001603 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 393133001604 Beta-lactamase; Region: Beta-lactamase; pfam00144 393133001605 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 393133001606 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 393133001607 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 393133001608 intersubunit interface [polypeptide binding]; other site 393133001609 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 393133001610 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 393133001611 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 393133001612 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 393133001613 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 393133001614 Glucitol operon activator protein (GutM); Region: GutM; cl01890 393133001615 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 393133001616 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133001617 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 393133001618 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393133001619 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393133001620 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133001621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001622 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001623 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001624 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133001625 WxL domain surface cell wall-binding; Region: WxL; pfam13731 393133001626 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 393133001627 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 393133001628 FOG: CBS domain [General function prediction only]; Region: COG0517 393133001629 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 393133001630 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 393133001631 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 393133001632 dimer interface [polypeptide binding]; other site 393133001633 active site 393133001634 metal binding site [ion binding]; metal-binding site 393133001635 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 393133001636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133001637 putative substrate translocation pore; other site 393133001638 POT family; Region: PTR2; pfam00854 393133001639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133001640 catalytic core [active] 393133001641 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133001642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133001643 catalytic core [active] 393133001644 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 393133001645 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 393133001646 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393133001647 Cl binding site [ion binding]; other site 393133001648 oligomer interface [polypeptide binding]; other site 393133001649 glutamate dehydrogenase; Provisional; Region: PRK09414 393133001650 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 393133001651 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 393133001652 NAD(P) binding site [chemical binding]; other site 393133001653 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 393133001654 metal binding site [ion binding]; metal-binding site 393133001655 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 393133001656 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 393133001657 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 393133001658 substrate binding site [chemical binding]; other site 393133001659 glutamase interaction surface [polypeptide binding]; other site 393133001660 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 393133001661 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 393133001662 catalytic residues [active] 393133001663 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 393133001664 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 393133001665 putative active site [active] 393133001666 oxyanion strand; other site 393133001667 catalytic triad [active] 393133001668 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 393133001669 putative active site pocket [active] 393133001670 4-fold oligomerization interface [polypeptide binding]; other site 393133001671 metal binding residues [ion binding]; metal-binding site 393133001672 3-fold/trimer interface [polypeptide binding]; other site 393133001673 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 393133001674 histidinol dehydrogenase; Region: hisD; TIGR00069 393133001675 NAD binding site [chemical binding]; other site 393133001676 dimerization interface [polypeptide binding]; other site 393133001677 product binding site; other site 393133001678 substrate binding site [chemical binding]; other site 393133001679 zinc binding site [ion binding]; other site 393133001680 catalytic residues [active] 393133001681 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 393133001682 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 393133001683 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 393133001684 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 393133001685 dimer interface [polypeptide binding]; other site 393133001686 motif 1; other site 393133001687 active site 393133001688 motif 2; other site 393133001689 motif 3; other site 393133001690 histidinol-phosphatase; Reviewed; Region: PRK08123 393133001691 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 393133001692 active site 393133001693 dimer interface [polypeptide binding]; other site 393133001694 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393133001695 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393133001696 DNA binding site [nucleotide binding] 393133001697 active site 393133001698 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 393133001699 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393133001700 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133001701 beta-galactosidase; Region: BGL; TIGR03356 393133001702 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133001703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133001704 DNA-binding site [nucleotide binding]; DNA binding site 393133001705 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393133001706 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001707 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133001708 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 393133001709 Uncharacterized conserved protein [Function unknown]; Region: COG2966 393133001710 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 393133001711 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 393133001712 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 393133001713 Predicted esterase [General function prediction only]; Region: COG0400 393133001714 putative hydrolase; Provisional; Region: PRK11460 393133001715 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 393133001716 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 393133001717 putative RNA binding site [nucleotide binding]; other site 393133001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133001719 S-adenosylmethionine binding site [chemical binding]; other site 393133001720 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 393133001721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133001722 Bacterial SH3 domain; Region: SH3_3; pfam08239 393133001723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133001724 NlpC/P60 family; Region: NLPC_P60; pfam00877 393133001725 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 393133001726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393133001727 ATP binding site [chemical binding]; other site 393133001728 putative Mg++ binding site [ion binding]; other site 393133001729 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 393133001730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 393133001731 nucleotide binding region [chemical binding]; other site 393133001732 ATP-binding site [chemical binding]; other site 393133001733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393133001734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393133001735 WxL domain surface cell wall-binding; Region: WxL; pfam13731 393133001736 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 393133001737 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 393133001738 UreD urease accessory protein; Region: UreD; cl00530 393133001739 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 393133001740 DNA photolyase; Region: DNA_photolyase; pfam00875 393133001741 Predicted membrane protein [Function unknown]; Region: COG4852 393133001742 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 393133001743 DAK2 domain; Region: Dak2; pfam02734 393133001744 EDD domain protein, DegV family; Region: DegV; TIGR00762 393133001745 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393133001746 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 393133001747 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 393133001748 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 393133001749 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 393133001750 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 393133001751 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393133001752 homodimer interface [polypeptide binding]; other site 393133001753 substrate-cofactor binding pocket; other site 393133001754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133001755 catalytic residue [active] 393133001756 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 393133001757 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133001758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393133001759 ligand binding site [chemical binding]; other site 393133001760 flexible hinge region; other site 393133001761 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133001762 BioY family; Region: BioY; pfam02632 393133001763 Predicted transcriptional regulators [Transcription]; Region: COG1695 393133001764 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 393133001765 Predicted membrane protein [Function unknown]; Region: COG4709 393133001766 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393133001767 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133001768 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133001769 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133001770 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133001771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393133001772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133001773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393133001774 Coenzyme A binding pocket [chemical binding]; other site 393133001775 Tic20-like protein; Region: Tic20; pfam09685 393133001776 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 393133001777 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393133001778 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393133001779 MarR family; Region: MarR_2; pfam12802 393133001780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133001781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133001782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133001783 Walker A/P-loop; other site 393133001784 ATP binding site [chemical binding]; other site 393133001785 Q-loop/lid; other site 393133001786 ABC transporter signature motif; other site 393133001787 Walker B; other site 393133001788 D-loop; other site 393133001789 H-loop/switch region; other site 393133001790 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133001791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133001792 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 393133001793 Walker A/P-loop; other site 393133001794 ATP binding site [chemical binding]; other site 393133001795 Q-loop/lid; other site 393133001796 ABC transporter signature motif; other site 393133001797 Walker B; other site 393133001798 D-loop; other site 393133001799 H-loop/switch region; other site 393133001800 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393133001801 active site residue [active] 393133001802 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001803 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133001804 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393133001805 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393133001806 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393133001807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133001808 putative DNA binding site [nucleotide binding]; other site 393133001809 putative Zn2+ binding site [ion binding]; other site 393133001810 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 393133001811 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 393133001812 putative NAD(P) binding site [chemical binding]; other site 393133001813 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393133001814 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393133001815 Coenzyme A binding pocket [chemical binding]; other site 393133001816 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 393133001817 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393133001818 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 393133001819 putative active site [active] 393133001820 catalytic site [active] 393133001821 putative metal binding site [ion binding]; other site 393133001822 Catalytic domain of Protein Kinases; Region: PKc; cd00180 393133001823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 393133001824 active site 393133001825 ATP binding site [chemical binding]; other site 393133001826 substrate binding site [chemical binding]; other site 393133001827 activation loop (A-loop); other site 393133001828 Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915 393133001829 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 393133001830 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 393133001831 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393133001832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133001833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133001834 Coenzyme A binding pocket [chemical binding]; other site 393133001835 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 393133001836 active site 393133001837 catalytic triad [active] 393133001838 oxyanion hole [active] 393133001839 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393133001840 domain interaction interfaces [polypeptide binding]; other site 393133001841 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393133001842 domain interaction interfaces [polypeptide binding]; other site 393133001843 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393133001844 domain interaction interfaces [polypeptide binding]; other site 393133001845 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393133001846 domain interaction interfaces [polypeptide binding]; other site 393133001847 Isochorismatase family; Region: Isochorismatase; pfam00857 393133001848 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 393133001849 catalytic triad [active] 393133001850 conserved cis-peptide bond; other site 393133001851 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133001852 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133001853 PRD domain; Region: PRD; pfam00874 393133001854 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133001855 active site 393133001856 P-loop; other site 393133001857 phosphorylation site [posttranslational modification] 393133001858 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 393133001859 active site 393133001860 phosphorylation site [posttranslational modification] 393133001861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133001862 active site 393133001863 phosphorylation site [posttranslational modification] 393133001864 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 393133001865 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133001866 active site 393133001867 P-loop; other site 393133001868 phosphorylation site [posttranslational modification] 393133001869 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 393133001870 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 393133001871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133001872 motif II; other site 393133001873 Predicted transcriptional regulator [Transcription]; Region: COG1959 393133001874 Transcriptional regulator; Region: Rrf2; pfam02082 393133001875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393133001876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133001877 S-adenosylmethionine binding site [chemical binding]; other site 393133001878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393133001879 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 393133001880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133001881 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133001882 active site 393133001883 catalytic tetrad [active] 393133001884 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 393133001885 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133001886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133001887 motif II; other site 393133001888 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 393133001889 catalytic residue [active] 393133001890 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 393133001891 Sulfatase; Region: Sulfatase; pfam00884 393133001892 amino acid transporter; Region: 2A0306; TIGR00909 393133001893 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 393133001894 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 393133001895 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 393133001896 putative metal binding site [ion binding]; other site 393133001897 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 393133001898 active site 393133001899 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 393133001900 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393133001901 Cl binding site [ion binding]; other site 393133001902 oligomer interface [polypeptide binding]; other site 393133001903 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393133001904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133001905 DNA-binding site [nucleotide binding]; DNA binding site 393133001906 Predicted membrane protein [Function unknown]; Region: COG1511 393133001907 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393133001908 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 393133001909 linker region; other site 393133001910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133001911 Transcriptional regulators [Transcription]; Region: FadR; COG2186 393133001912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133001913 DNA-binding site [nucleotide binding]; DNA binding site 393133001914 FCD domain; Region: FCD; cl11656 393133001915 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393133001916 Predicted integral membrane protein [Function unknown]; Region: COG5523 393133001917 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393133001918 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 393133001919 active site 393133001920 metal binding site [ion binding]; metal-binding site 393133001921 Predicted membrane protein [Function unknown]; Region: COG2322 393133001922 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 393133001923 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393133001924 minor groove reading motif; other site 393133001925 helix-hairpin-helix signature motif; other site 393133001926 substrate binding pocket [chemical binding]; other site 393133001927 active site 393133001928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133001929 non-specific DNA binding site [nucleotide binding]; other site 393133001930 salt bridge; other site 393133001931 sequence-specific DNA binding site [nucleotide binding]; other site 393133001932 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393133001933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393133001934 Helix-turn-helix domain; Region: HTH_28; pfam13518 393133001935 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 393133001936 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 393133001937 dimer interface [polypeptide binding]; other site 393133001938 substrate binding site [chemical binding]; other site 393133001939 ATP binding site [chemical binding]; other site 393133001940 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133001941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133001942 active site 393133001943 motif I; other site 393133001944 motif II; other site 393133001945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133001946 maltose O-acetyltransferase; Provisional; Region: PRK10092 393133001947 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 393133001948 active site 393133001949 substrate binding site [chemical binding]; other site 393133001950 trimer interface [polypeptide binding]; other site 393133001951 CoA binding site [chemical binding]; other site 393133001952 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 393133001953 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133001954 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133001955 Walker A/P-loop; other site 393133001956 ATP binding site [chemical binding]; other site 393133001957 Q-loop/lid; other site 393133001958 ABC transporter signature motif; other site 393133001959 Walker B; other site 393133001960 D-loop; other site 393133001961 H-loop/switch region; other site 393133001962 inner membrane transport permease; Provisional; Region: PRK15066 393133001963 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393133001964 oxidoreductase; Provisional; Region: PRK07985 393133001965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393133001966 NAD(P) binding site [chemical binding]; other site 393133001967 active site 393133001968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 393133001969 Predicted membrane protein [Function unknown]; Region: COG3152 393133001970 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 393133001971 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 393133001972 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 393133001973 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 393133001974 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 393133001975 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 393133001976 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 393133001977 FHIPEP family; Region: FHIPEP; pfam00771 393133001978 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 393133001979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393133001980 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 393133001981 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393133001982 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 393133001983 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 393133001984 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 393133001985 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 393133001986 flagellar motor protein MotA; Validated; Region: PRK08124 393133001987 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 393133001988 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 393133001989 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 393133001990 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 393133001991 ligand binding site [chemical binding]; other site 393133001992 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 393133001993 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 393133001994 putative metal binding site; other site 393133001995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133001996 binding surface 393133001997 TPR motif; other site 393133001998 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 393133001999 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 393133002000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133002001 active site 393133002002 phosphorylation site [posttranslational modification] 393133002003 intermolecular recognition site; other site 393133002004 dimerization interface [polypeptide binding]; other site 393133002005 flagellin; Provisional; Region: PRK12805 393133002006 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 393133002007 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 393133002008 Response regulator receiver domain; Region: Response_reg; pfam00072 393133002009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133002010 active site 393133002011 phosphorylation site [posttranslational modification] 393133002012 intermolecular recognition site; other site 393133002013 dimerization interface [polypeptide binding]; other site 393133002014 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 393133002015 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 393133002016 putative binding surface; other site 393133002017 active site 393133002018 P2 response regulator binding domain; Region: P2; pfam07194 393133002019 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 393133002020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133002021 ATP binding site [chemical binding]; other site 393133002022 Mg2+ binding site [ion binding]; other site 393133002023 G-X-G motif; other site 393133002024 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 393133002025 flagellar motor switch protein; Validated; Region: PRK06788 393133002026 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 393133002027 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 393133002028 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 393133002029 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 393133002030 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 393133002031 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 393133002032 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393133002033 flagellar motor switch protein; Validated; Region: PRK06789 393133002034 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 393133002035 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 393133002036 flagellar motor switch protein; Reviewed; Region: PRK06782 393133002037 CheC-like family; Region: CheC; pfam04509 393133002038 CheC-like family; Region: CheC; pfam04509 393133002039 Chemotaxis phosphatase CheX; Region: CheX; cl15816 393133002040 CheC-like family; Region: CheC; pfam04509 393133002041 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 393133002042 Protein of unknown function (DUF327); Region: DUF327; pfam03885 393133002043 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 393133002044 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393133002045 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 393133002046 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 393133002047 flagellar capping protein; Validated; Region: fliD; PRK06798 393133002048 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 393133002049 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 393133002050 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 393133002051 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 393133002052 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 393133002053 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 393133002054 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393133002055 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 393133002056 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 393133002057 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 393133002058 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 393133002059 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 393133002060 FliG C-terminal domain; Region: FliG_C; pfam01706 393133002061 flagellar assembly protein H; Validated; Region: fliH; PRK06800 393133002062 Flagellar assembly protein FliH; Region: FliH; pfam02108 393133002063 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 393133002064 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393133002065 Walker A motif; other site 393133002066 ATP binding site [chemical binding]; other site 393133002067 Walker B motif; other site 393133002068 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 393133002069 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 393133002070 N-acetyl-D-glucosamine binding site [chemical binding]; other site 393133002071 catalytic residue [active] 393133002072 Predicted transcriptional regulators [Transcription]; Region: COG1695 393133002073 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 393133002074 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 393133002075 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 393133002076 pyruvate oxidase; Provisional; Region: PRK08611 393133002077 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 393133002078 PYR/PP interface [polypeptide binding]; other site 393133002079 dimer interface [polypeptide binding]; other site 393133002080 tetramer interface [polypeptide binding]; other site 393133002081 TPP binding site [chemical binding]; other site 393133002082 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393133002083 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 393133002084 TPP-binding site [chemical binding]; other site 393133002085 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 393133002086 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 393133002087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133002088 dimerization interface [polypeptide binding]; other site 393133002089 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 393133002090 dimer interface [polypeptide binding]; other site 393133002091 putative CheW interface [polypeptide binding]; other site 393133002092 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 393133002093 putative active site [active] 393133002094 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 393133002095 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 393133002096 glutaminase active site [active] 393133002097 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393133002098 dimer interface [polypeptide binding]; other site 393133002099 active site 393133002100 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393133002101 dimer interface [polypeptide binding]; other site 393133002102 active site 393133002103 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 393133002104 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 393133002105 active site 393133002106 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 393133002107 GIY-YIG motif/motif A; other site 393133002108 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133002109 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133002110 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002111 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133002112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133002113 non-specific DNA binding site [nucleotide binding]; other site 393133002114 salt bridge; other site 393133002115 sequence-specific DNA binding site [nucleotide binding]; other site 393133002116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133002117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133002118 DNA binding site [nucleotide binding] 393133002119 domain linker motif; other site 393133002120 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133002121 ligand binding site [chemical binding]; other site 393133002122 dimerization interface [polypeptide binding]; other site 393133002123 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133002124 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133002125 substrate binding site [chemical binding]; other site 393133002126 hexamer interface [polypeptide binding]; other site 393133002127 metal binding site [ion binding]; metal-binding site 393133002128 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 393133002129 BtpA family; Region: BtpA; cl00440 393133002130 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393133002131 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393133002132 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133002133 active site turn [active] 393133002134 phosphorylation site [posttranslational modification] 393133002135 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133002136 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393133002137 HPr interaction site; other site 393133002138 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133002139 active site 393133002140 phosphorylation site [posttranslational modification] 393133002141 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133002142 beta-galactosidase; Region: BGL; TIGR03356 393133002143 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133002144 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133002145 ligand binding site [chemical binding]; other site 393133002146 flexible hinge region; other site 393133002147 Predicted transcriptional regulators [Transcription]; Region: COG1725 393133002148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002149 DNA-binding site [nucleotide binding]; DNA binding site 393133002150 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393133002151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133002152 Walker A/P-loop; other site 393133002153 ATP binding site [chemical binding]; other site 393133002154 Q-loop/lid; other site 393133002155 ABC transporter signature motif; other site 393133002156 Walker B; other site 393133002157 D-loop; other site 393133002158 H-loop/switch region; other site 393133002159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133002160 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133002161 Walker A/P-loop; other site 393133002162 ATP binding site [chemical binding]; other site 393133002163 Q-loop/lid; other site 393133002164 ABC transporter signature motif; other site 393133002165 Walker B; other site 393133002166 D-loop; other site 393133002167 H-loop/switch region; other site 393133002168 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393133002169 FtsX-like permease family; Region: FtsX; pfam02687 393133002170 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133002171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133002172 non-specific DNA binding site [nucleotide binding]; other site 393133002173 salt bridge; other site 393133002174 sequence-specific DNA binding site [nucleotide binding]; other site 393133002175 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393133002176 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133002177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393133002178 ligand binding site [chemical binding]; other site 393133002179 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393133002180 non-specific DNA interactions [nucleotide binding]; other site 393133002181 DNA binding site [nucleotide binding] 393133002182 sequence specific DNA binding site [nucleotide binding]; other site 393133002183 putative cAMP binding site [chemical binding]; other site 393133002184 SnoaL-like domain; Region: SnoaL_4; pfam13577 393133002185 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 393133002186 active site 393133002187 catalytic triad [active] 393133002188 oxyanion hole [active] 393133002189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133002190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133002191 Walker A/P-loop; other site 393133002192 ATP binding site [chemical binding]; other site 393133002193 Q-loop/lid; other site 393133002194 ABC transporter signature motif; other site 393133002195 Walker B; other site 393133002196 D-loop; other site 393133002197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393133002198 H-loop/switch region; other site 393133002199 active site 393133002200 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 393133002201 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393133002202 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393133002203 Zn binding site [ion binding]; other site 393133002204 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393133002205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133002206 Zn binding site [ion binding]; other site 393133002207 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393133002208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133002209 Zn binding site [ion binding]; other site 393133002210 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393133002211 Zn binding site [ion binding]; other site 393133002212 Predicted esterase [General function prediction only]; Region: COG0400 393133002213 putative hydrolase; Provisional; Region: PRK11460 393133002214 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 393133002215 GTPases [General function prediction only]; Region: HflX; COG2262 393133002216 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 393133002217 HflX GTPase family; Region: HflX; cd01878 393133002218 G1 box; other site 393133002219 GTP/Mg2+ binding site [chemical binding]; other site 393133002220 Switch I region; other site 393133002221 G2 box; other site 393133002222 G3 box; other site 393133002223 Switch II region; other site 393133002224 G4 box; other site 393133002225 G5 box; other site 393133002226 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 393133002227 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393133002228 putative active site [active] 393133002229 putative metal binding site [ion binding]; other site 393133002230 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 393133002231 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393133002232 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 393133002233 Uncharacterized conserved protein [Function unknown]; Region: COG3538 393133002234 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 393133002235 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393133002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002237 dimer interface [polypeptide binding]; other site 393133002238 conserved gate region; other site 393133002239 putative PBP binding loops; other site 393133002240 ABC-ATPase subunit interface; other site 393133002241 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002243 dimer interface [polypeptide binding]; other site 393133002244 conserved gate region; other site 393133002245 putative PBP binding loops; other site 393133002246 ABC-ATPase subunit interface; other site 393133002247 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393133002248 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 393133002249 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 393133002250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002251 DNA-binding site [nucleotide binding]; DNA binding site 393133002252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133002253 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133002254 ligand binding site [chemical binding]; other site 393133002255 dimerization interface [polypeptide binding]; other site 393133002256 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393133002257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002258 DNA-binding site [nucleotide binding]; DNA binding site 393133002259 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 393133002260 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 393133002261 putative NADP binding site [chemical binding]; other site 393133002262 putative dimer interface [polypeptide binding]; other site 393133002263 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 393133002264 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393133002265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133002266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133002267 nucleotide binding site [chemical binding]; other site 393133002268 Predicted membrane protein [Function unknown]; Region: COG4811 393133002269 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 393133002270 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 393133002271 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393133002272 active site 393133002273 phosphorylation site [posttranslational modification] 393133002274 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133002275 active pocket/dimerization site; other site 393133002276 active site 393133002277 phosphorylation site [posttranslational modification] 393133002278 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 393133002279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133002280 Walker A motif; other site 393133002281 ATP binding site [chemical binding]; other site 393133002282 Walker B motif; other site 393133002283 arginine finger; other site 393133002284 Transcriptional antiterminator [Transcription]; Region: COG3933 393133002285 PRD domain; Region: PRD; pfam00874 393133002286 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133002287 active pocket/dimerization site; other site 393133002288 active site 393133002289 phosphorylation site [posttranslational modification] 393133002290 PRD domain; Region: PRD; pfam00874 393133002291 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 393133002292 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393133002293 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 393133002294 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393133002295 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 393133002296 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393133002297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 393133002298 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 393133002299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 393133002300 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 393133002301 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393133002302 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 393133002303 putative deacylase active site [active] 393133002304 Predicted amidohydrolase [General function prediction only]; Region: COG0388 393133002305 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 393133002306 active site 393133002307 catalytic triad [active] 393133002308 dimer interface [polypeptide binding]; other site 393133002309 Protein of unknown function (DUF554); Region: DUF554; pfam04474 393133002310 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 393133002311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 393133002312 NAD binding site [chemical binding]; other site 393133002313 substrate binding site [chemical binding]; other site 393133002314 putative active site [active] 393133002315 Predicted permeases [General function prediction only]; Region: RarD; COG2962 393133002316 EamA-like transporter family; Region: EamA; pfam00892 393133002317 Uncharacterized conserved protein [Function unknown]; Region: COG2353 393133002318 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393133002319 MarR family; Region: MarR_2; pfam12802 393133002320 lysine transporter; Provisional; Region: PRK10836 393133002321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393133002322 PAS domain; Region: PAS_9; pfam13426 393133002323 putative active site [active] 393133002324 heme pocket [chemical binding]; other site 393133002325 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133002326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 393133002327 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133002328 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133002329 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133002330 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133002331 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133002332 LRR adjacent; Region: LRR_adjacent; pfam08191 393133002333 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393133002334 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393133002335 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393133002336 synthetase active site [active] 393133002337 NTP binding site [chemical binding]; other site 393133002338 metal binding site [ion binding]; metal-binding site 393133002339 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393133002340 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 393133002341 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133002342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133002343 non-specific DNA binding site [nucleotide binding]; other site 393133002344 salt bridge; other site 393133002345 sequence-specific DNA binding site [nucleotide binding]; other site 393133002346 Cupin domain; Region: Cupin_2; pfam07883 393133002347 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 393133002348 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 393133002349 Walker A/P-loop; other site 393133002350 ATP binding site [chemical binding]; other site 393133002351 Q-loop/lid; other site 393133002352 ABC transporter signature motif; other site 393133002353 Walker B; other site 393133002354 D-loop; other site 393133002355 H-loop/switch region; other site 393133002356 TOBE domain; Region: TOBE_2; pfam08402 393133002357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 393133002358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002359 putative PBP binding loops; other site 393133002360 ABC-ATPase subunit interface; other site 393133002361 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 393133002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002363 dimer interface [polypeptide binding]; other site 393133002364 conserved gate region; other site 393133002365 putative PBP binding loops; other site 393133002366 ABC-ATPase subunit interface; other site 393133002367 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 393133002368 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 393133002369 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 393133002370 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 393133002371 active site 393133002372 zinc binding site [ion binding]; other site 393133002373 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393133002374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133002375 Zn2+ binding site [ion binding]; other site 393133002376 Mg2+ binding site [ion binding]; other site 393133002377 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133002378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133002379 nucleotide binding site [chemical binding]; other site 393133002380 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 393133002381 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 393133002382 FMN binding site [chemical binding]; other site 393133002383 substrate binding site [chemical binding]; other site 393133002384 putative catalytic residue [active] 393133002385 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133002386 MarR family; Region: MarR_2; pfam12802 393133002387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393133002388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133002389 Coenzyme A binding pocket [chemical binding]; other site 393133002390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393133002391 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393133002392 dimer interface [polypeptide binding]; other site 393133002393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133002394 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 393133002395 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393133002396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133002397 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393133002398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133002399 motif II; other site 393133002400 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393133002401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393133002402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133002403 Coenzyme A binding pocket [chemical binding]; other site 393133002404 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 393133002405 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133002406 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133002407 DNA binding residues [nucleotide binding] 393133002408 putative dimer interface [polypeptide binding]; other site 393133002409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133002410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133002411 active site 393133002412 catalytic tetrad [active] 393133002413 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 393133002414 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 393133002415 homodimer interface [polypeptide binding]; other site 393133002416 catalytic residues [active] 393133002417 NAD binding site [chemical binding]; other site 393133002418 substrate binding pocket [chemical binding]; other site 393133002419 flexible flap; other site 393133002420 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 393133002421 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 393133002422 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 393133002423 PhoU domain; Region: PhoU; pfam01895 393133002424 PhoU domain; Region: PhoU; pfam01895 393133002425 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 393133002426 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 393133002427 dimer interface [polypeptide binding]; other site 393133002428 PYR/PP interface [polypeptide binding]; other site 393133002429 TPP binding site [chemical binding]; other site 393133002430 substrate binding site [chemical binding]; other site 393133002431 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 393133002432 Domain of unknown function; Region: EKR; smart00890 393133002433 4Fe-4S binding domain; Region: Fer4_6; pfam12837 393133002434 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 393133002435 TPP-binding site [chemical binding]; other site 393133002436 dimer interface [polypeptide binding]; other site 393133002437 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 393133002438 Predicted permeases [General function prediction only]; Region: COG0679 393133002439 Helix-turn-helix domain; Region: HTH_28; pfam13518 393133002440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133002441 non-specific DNA binding site [nucleotide binding]; other site 393133002442 salt bridge; other site 393133002443 sequence-specific DNA binding site [nucleotide binding]; other site 393133002444 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393133002445 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133002446 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133002447 Predicted membrane protein [Function unknown]; Region: COG3223 393133002448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133002449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133002450 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393133002451 Walker A/P-loop; other site 393133002452 ATP binding site [chemical binding]; other site 393133002453 Q-loop/lid; other site 393133002454 ABC transporter signature motif; other site 393133002455 Walker B; other site 393133002456 D-loop; other site 393133002457 H-loop/switch region; other site 393133002458 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 393133002459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002460 putative substrate translocation pore; other site 393133002461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133002464 putative substrate translocation pore; other site 393133002465 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133002466 MarR family; Region: MarR; pfam01047 393133002467 MarR family; Region: MarR_2; cl17246 393133002468 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 393133002469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393133002470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133002471 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393133002472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133002473 motif II; other site 393133002474 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393133002475 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002476 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002477 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002478 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002479 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002480 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002481 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133002482 Predicted membrane protein [Function unknown]; Region: COG3326 393133002483 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 393133002484 homotrimer interaction site [polypeptide binding]; other site 393133002485 putative active site [active] 393133002486 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 393133002487 substrate binding site [chemical binding]; other site 393133002488 zinc-binding site [ion binding]; other site 393133002489 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 393133002490 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 393133002491 GIY-YIG motif/motif A; other site 393133002492 active site 393133002493 catalytic site [active] 393133002494 putative DNA binding site [nucleotide binding]; other site 393133002495 metal binding site [ion binding]; metal-binding site 393133002496 UvrB/uvrC motif; Region: UVR; pfam02151 393133002497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393133002498 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393133002499 substrate binding pocket [chemical binding]; other site 393133002500 membrane-bound complex binding site; other site 393133002501 hinge residues; other site 393133002502 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393133002503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002504 dimer interface [polypeptide binding]; other site 393133002505 conserved gate region; other site 393133002506 putative PBP binding loops; other site 393133002507 ABC-ATPase subunit interface; other site 393133002508 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393133002509 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393133002510 Walker A/P-loop; other site 393133002511 ATP binding site [chemical binding]; other site 393133002512 Q-loop/lid; other site 393133002513 ABC transporter signature motif; other site 393133002514 Walker B; other site 393133002515 D-loop; other site 393133002516 H-loop/switch region; other site 393133002517 amidase; Provisional; Region: PRK11910 393133002518 Amidase; Region: Amidase; cl11426 393133002519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133002520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133002521 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 393133002522 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 393133002523 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 393133002524 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 393133002525 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 393133002526 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 393133002527 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393133002528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393133002529 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 393133002530 Esterase/lipase [General function prediction only]; Region: COG1647 393133002531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133002532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133002533 DNA binding site [nucleotide binding] 393133002534 domain linker motif; other site 393133002535 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 393133002536 putative dimerization interface [polypeptide binding]; other site 393133002537 putative ligand binding site [chemical binding]; other site 393133002538 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393133002539 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133002540 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 393133002541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002542 dimer interface [polypeptide binding]; other site 393133002543 conserved gate region; other site 393133002544 putative PBP binding loops; other site 393133002545 ABC-ATPase subunit interface; other site 393133002546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133002548 dimer interface [polypeptide binding]; other site 393133002549 conserved gate region; other site 393133002550 ABC-ATPase subunit interface; other site 393133002551 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393133002552 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393133002553 Ca binding site [ion binding]; other site 393133002554 active site 393133002555 catalytic site [active] 393133002556 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 393133002557 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 393133002558 active site 393133002559 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 393133002560 active site 393133002561 substrate binding site [chemical binding]; other site 393133002562 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 393133002563 metal binding site [ion binding]; metal-binding site 393133002564 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393133002565 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393133002566 ATP binding site [chemical binding]; other site 393133002567 Mg++ binding site [ion binding]; other site 393133002568 motif III; other site 393133002569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133002570 nucleotide binding region [chemical binding]; other site 393133002571 ATP-binding site [chemical binding]; other site 393133002572 Predicted membrane protein [Function unknown]; Region: COG4708 393133002573 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 393133002574 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 393133002575 Predicted transcriptional regulators [Transcription]; Region: COG1733 393133002576 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 393133002577 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 393133002578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002579 putative substrate translocation pore; other site 393133002580 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133002581 PRD domain; Region: PRD; pfam00874 393133002582 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133002583 active site 393133002584 P-loop; other site 393133002585 phosphorylation site [posttranslational modification] 393133002586 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133002587 active site 393133002588 phosphorylation site [posttranslational modification] 393133002589 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133002590 methionine cluster; other site 393133002591 active site 393133002592 phosphorylation site [posttranslational modification] 393133002593 metal binding site [ion binding]; metal-binding site 393133002594 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133002595 active site 393133002596 P-loop; other site 393133002597 phosphorylation site [posttranslational modification] 393133002598 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133002599 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133002600 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393133002601 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393133002602 active site 393133002603 trimer interface [polypeptide binding]; other site 393133002604 allosteric site; other site 393133002605 active site lid [active] 393133002606 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393133002607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133002608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133002609 active site 393133002610 catalytic tetrad [active] 393133002611 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 393133002612 Collagen binding domain; Region: Collagen_bind; pfam05737 393133002613 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 393133002614 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133002615 Uncharacterized conserved protein [Function unknown]; Region: COG3402 393133002616 Predicted membrane protein [Function unknown]; Region: COG3428 393133002617 Bacterial PH domain; Region: DUF304; pfam03703 393133002618 Bacterial PH domain; Region: DUF304; pfam03703 393133002619 Bacterial PH domain; Region: DUF304; pfam03703 393133002620 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 393133002621 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 393133002622 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 393133002623 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 393133002624 active site 393133002625 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393133002626 dimer interface [polypeptide binding]; other site 393133002627 substrate binding site [chemical binding]; other site 393133002628 catalytic residues [active] 393133002629 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 393133002630 PemK-like protein; Region: PemK; pfam02452 393133002631 Rsbr N terminal; Region: Rsbr_N; pfam08678 393133002632 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133002633 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133002634 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 393133002635 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 393133002636 ATP binding site [chemical binding]; other site 393133002637 Mg2+ binding site [ion binding]; other site 393133002638 G-X-G motif; other site 393133002639 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 393133002640 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 393133002641 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 393133002642 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 393133002643 anti sigma factor interaction site; other site 393133002644 regulatory phosphorylation site [posttranslational modification]; other site 393133002645 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 393133002646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133002647 ATP binding site [chemical binding]; other site 393133002648 Mg2+ binding site [ion binding]; other site 393133002649 G-X-G motif; other site 393133002650 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 393133002651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393133002652 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 393133002653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393133002654 DNA binding residues [nucleotide binding] 393133002655 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 393133002656 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 393133002657 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 393133002658 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393133002659 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 393133002660 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 393133002661 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 393133002662 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 393133002663 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 393133002664 RNA binding site [nucleotide binding]; other site 393133002665 hypothetical protein; Provisional; Region: PRK04351 393133002666 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 393133002667 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 393133002668 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 393133002669 Uncharacterized conserved protein [Function unknown]; Region: COG5646 393133002670 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133002671 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133002672 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133002673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002674 DNA-binding site [nucleotide binding]; DNA binding site 393133002675 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393133002676 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 393133002677 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 393133002678 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 393133002679 glutathione reductase; Validated; Region: PRK06116 393133002680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133002681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133002682 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393133002683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133002684 catalytic core [active] 393133002685 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393133002686 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393133002687 Predicted transcriptional regulators [Transcription]; Region: COG1725 393133002688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002689 DNA-binding site [nucleotide binding]; DNA binding site 393133002690 Predicted membrane protein [General function prediction only]; Region: COG4194 393133002691 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 393133002692 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 393133002693 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 393133002694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 393133002695 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 393133002696 tetramerization interface [polypeptide binding]; other site 393133002697 NAD(P) binding site [chemical binding]; other site 393133002698 catalytic residues [active] 393133002699 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 393133002700 active site 393133002701 P-loop; other site 393133002702 phosphorylation site [posttranslational modification] 393133002703 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133002704 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133002705 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133002706 methionine cluster; other site 393133002707 active site 393133002708 phosphorylation site [posttranslational modification] 393133002709 metal binding site [ion binding]; metal-binding site 393133002710 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133002711 beta-galactosidase; Region: BGL; TIGR03356 393133002712 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133002713 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133002714 PRD domain; Region: PRD; pfam00874 393133002715 PRD domain; Region: PRD; pfam00874 393133002716 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133002717 active site 393133002718 phosphorylation site [posttranslational modification] 393133002719 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133002720 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 393133002721 ABC transporter; Region: ABC_tran_2; pfam12848 393133002722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133002723 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 393133002724 Predicted permeases [General function prediction only]; Region: COG0701 393133002725 Predicted membrane protein [Function unknown]; Region: COG3689 393133002726 pantothenate kinase; Provisional; Region: PRK05439 393133002727 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 393133002728 ATP-binding site [chemical binding]; other site 393133002729 CoA-binding site [chemical binding]; other site 393133002730 Mg2+-binding site [ion binding]; other site 393133002731 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 393133002732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133002733 Walker A/P-loop; other site 393133002734 ATP binding site [chemical binding]; other site 393133002735 Q-loop/lid; other site 393133002736 ABC transporter signature motif; other site 393133002737 Walker B; other site 393133002738 D-loop; other site 393133002739 H-loop/switch region; other site 393133002740 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393133002741 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393133002742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133002743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133002744 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 393133002745 Domain of unknown function (DUF373); Region: DUF373; cl12079 393133002746 Sulfatase; Region: Sulfatase; pfam00884 393133002747 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 393133002748 active site 393133002749 DNA binding site [nucleotide binding] 393133002750 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 393133002751 active site 393133002752 catalytic site [active] 393133002753 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 393133002754 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393133002755 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 393133002756 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 393133002757 Uncharacterized conserved protein [Function unknown]; Region: COG0398 393133002758 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393133002759 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393133002760 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393133002761 Ligand binding site; other site 393133002762 Putative Catalytic site; other site 393133002763 DXD motif; other site 393133002764 epoxyqueuosine reductase; Region: TIGR00276 393133002765 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 393133002766 A new structural DNA glycosylase; Region: AlkD_like; cl11434 393133002767 active site 393133002768 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 393133002769 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 393133002770 dimer interface [polypeptide binding]; other site 393133002771 FMN binding site [chemical binding]; other site 393133002772 NADPH bind site [chemical binding]; other site 393133002773 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393133002774 Low molecular weight phosphatase family; Region: LMWPc; cd00115 393133002775 active site 393133002776 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 393133002777 HSP90 family protein; Provisional; Region: PRK14083 393133002778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133002779 ATP binding site [chemical binding]; other site 393133002780 Mg2+ binding site [ion binding]; other site 393133002781 G-X-G motif; other site 393133002782 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 393133002783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 393133002784 dimerization interface [polypeptide binding]; other site 393133002785 DPS ferroxidase diiron center [ion binding]; other site 393133002786 ion pore; other site 393133002787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 393133002788 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 393133002789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133002790 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 393133002791 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 393133002792 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 393133002793 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 393133002794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002795 putative substrate translocation pore; other site 393133002796 Transcriptional regulators [Transcription]; Region: FadR; COG2186 393133002797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002798 DNA-binding site [nucleotide binding]; DNA binding site 393133002799 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 393133002800 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393133002801 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393133002802 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 393133002803 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 393133002804 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 393133002805 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 393133002806 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 393133002807 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 393133002808 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 393133002809 active site 393133002810 dimer interface [polypeptide binding]; other site 393133002811 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393133002812 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393133002813 active site 393133002814 trimer interface [polypeptide binding]; other site 393133002815 allosteric site; other site 393133002816 active site lid [active] 393133002817 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393133002818 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133002819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133002820 DNA-binding site [nucleotide binding]; DNA binding site 393133002821 UTRA domain; Region: UTRA; pfam07702 393133002822 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 393133002823 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 393133002824 Mg++ binding site [ion binding]; other site 393133002825 putative catalytic motif [active] 393133002826 substrate binding site [chemical binding]; other site 393133002827 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 393133002828 Peptidase family U32; Region: Peptidase_U32; pfam01136 393133002829 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 393133002830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393133002831 Peptidase family U32; Region: Peptidase_U32; pfam01136 393133002832 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 393133002833 heat shock protein HtpX; Provisional; Region: PRK04897 393133002834 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 393133002835 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 393133002836 catalytic residues [active] 393133002837 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 393133002838 putative active site [active] 393133002839 putative metal binding residues [ion binding]; other site 393133002840 signature motif; other site 393133002841 putative triphosphate binding site [ion binding]; other site 393133002842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133002843 TPR motif; other site 393133002844 binding surface 393133002845 TPR repeat; Region: TPR_11; pfam13414 393133002846 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393133002847 synthetase active site [active] 393133002848 NTP binding site [chemical binding]; other site 393133002849 metal binding site [ion binding]; metal-binding site 393133002850 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 393133002851 ATP-NAD kinase; Region: NAD_kinase; pfam01513 393133002852 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393133002853 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393133002854 active site 393133002855 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 393133002856 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 393133002857 NAD binding site [chemical binding]; other site 393133002858 homotetramer interface [polypeptide binding]; other site 393133002859 homodimer interface [polypeptide binding]; other site 393133002860 substrate binding site [chemical binding]; other site 393133002861 active site 393133002862 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 393133002863 DltD N-terminal region; Region: DltD_N; pfam04915 393133002864 DltD central region; Region: DltD_M; pfam04918 393133002865 DltD C-terminal region; Region: DltD_C; pfam04914 393133002866 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 393133002867 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 393133002868 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 393133002869 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 393133002870 acyl-activating enzyme (AAE) consensus motif; other site 393133002871 AMP binding site [chemical binding]; other site 393133002872 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 393133002873 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 393133002874 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133002875 active site 393133002876 dimer interface [polypeptide binding]; other site 393133002877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133002878 Coenzyme A binding pocket [chemical binding]; other site 393133002879 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 393133002880 Putative esterase; Region: Esterase; pfam00756 393133002881 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 393133002882 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 393133002883 homodimer interface [polypeptide binding]; other site 393133002884 substrate-cofactor binding pocket; other site 393133002885 catalytic residue [active] 393133002886 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393133002887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133002888 Walker A/P-loop; other site 393133002889 ATP binding site [chemical binding]; other site 393133002890 Q-loop/lid; other site 393133002891 ABC transporter signature motif; other site 393133002892 Walker B; other site 393133002893 D-loop; other site 393133002894 H-loop/switch region; other site 393133002895 ABC-2 type transporter; Region: ABC2_membrane; cl17235 393133002896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393133002897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133002898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133002899 putative substrate translocation pore; other site 393133002900 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393133002901 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 393133002902 putative oligomer interface [polypeptide binding]; other site 393133002903 putative active site [active] 393133002904 metal binding site [ion binding]; metal-binding site 393133002905 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 393133002906 catalytic residues [active] 393133002907 dimer interface [polypeptide binding]; other site 393133002908 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 393133002909 LytTr DNA-binding domain; Region: LytTR; pfam04397 393133002910 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133002911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133002912 Walker A/P-loop; other site 393133002913 ATP binding site [chemical binding]; other site 393133002914 Q-loop/lid; other site 393133002915 ABC transporter signature motif; other site 393133002916 Walker B; other site 393133002917 D-loop; other site 393133002918 H-loop/switch region; other site 393133002919 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 393133002920 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393133002921 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 393133002922 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 393133002923 G1 box; other site 393133002924 putative GEF interaction site [polypeptide binding]; other site 393133002925 GTP/Mg2+ binding site [chemical binding]; other site 393133002926 Switch I region; other site 393133002927 G2 box; other site 393133002928 G3 box; other site 393133002929 Switch II region; other site 393133002930 G4 box; other site 393133002931 G5 box; other site 393133002932 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 393133002933 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133002934 MarR family; Region: MarR_2; cl17246 393133002935 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393133002936 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393133002937 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 393133002938 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 393133002939 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 393133002940 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 393133002941 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 393133002942 Acyltransferase family; Region: Acyl_transf_3; pfam01757 393133002943 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393133002944 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393133002945 DNA binding site [nucleotide binding] 393133002946 active site 393133002947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133002948 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 393133002949 Walker A motif; other site 393133002950 ATP binding site [chemical binding]; other site 393133002951 Walker B motif; other site 393133002952 arginine finger; other site 393133002953 UvrB/uvrC motif; Region: UVR; pfam02151 393133002954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133002955 Walker A motif; other site 393133002956 ATP binding site [chemical binding]; other site 393133002957 Walker B motif; other site 393133002958 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 393133002959 CAAX protease self-immunity; Region: Abi; pfam02517 393133002960 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 393133002961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393133002962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 393133002963 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 393133002964 dimerization domain swap beta strand [polypeptide binding]; other site 393133002965 regulatory protein interface [polypeptide binding]; other site 393133002966 active site 393133002967 regulatory phosphorylation site [posttranslational modification]; other site 393133002968 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 393133002969 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 393133002970 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393133002971 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 393133002972 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 393133002973 Uncharacterized conserved protein [Function unknown]; Region: COG1434 393133002974 putative active site [active] 393133002975 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 393133002976 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 393133002977 aminotransferase A; Validated; Region: PRK07683 393133002978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133002979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133002980 homodimer interface [polypeptide binding]; other site 393133002981 catalytic residue [active] 393133002982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 393133002983 FOG: CBS domain [General function prediction only]; Region: COG0517 393133002984 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 393133002985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133002986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133002987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393133002988 dimerization interface [polypeptide binding]; other site 393133002989 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 393133002990 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 393133002991 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393133002992 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393133002993 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393133002994 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 393133002995 metal binding site [ion binding]; metal-binding site 393133002996 putative dimer interface [polypeptide binding]; other site 393133002997 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 393133002998 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 393133002999 Mechanosensitive ion channel; Region: MS_channel; pfam00924 393133003000 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 393133003001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133003002 Walker A/P-loop; other site 393133003003 ATP binding site [chemical binding]; other site 393133003004 Q-loop/lid; other site 393133003005 ABC transporter signature motif; other site 393133003006 Walker B; other site 393133003007 D-loop; other site 393133003008 H-loop/switch region; other site 393133003009 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393133003010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133003011 dimer interface [polypeptide binding]; other site 393133003012 conserved gate region; other site 393133003013 putative PBP binding loops; other site 393133003014 ABC-ATPase subunit interface; other site 393133003015 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 393133003016 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393133003017 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393133003018 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 393133003019 HPr interaction site; other site 393133003020 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133003021 active site 393133003022 phosphorylation site [posttranslational modification] 393133003023 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 393133003024 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 393133003025 S1 domain; Region: S1_2; pfam13509 393133003026 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 393133003027 RNA binding site [nucleotide binding]; other site 393133003028 Predicted membrane protein [Function unknown]; Region: COG4758 393133003029 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 393133003030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 393133003031 Histidine kinase; Region: HisKA_3; pfam07730 393133003032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133003033 ATP binding site [chemical binding]; other site 393133003034 Mg2+ binding site [ion binding]; other site 393133003035 G-X-G motif; other site 393133003036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 393133003037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133003038 active site 393133003039 phosphorylation site [posttranslational modification] 393133003040 intermolecular recognition site; other site 393133003041 dimerization interface [polypeptide binding]; other site 393133003042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 393133003043 DNA binding residues [nucleotide binding] 393133003044 dimerization interface [polypeptide binding]; other site 393133003045 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 393133003046 TrkA-N domain; Region: TrkA_N; pfam02254 393133003047 TrkA-C domain; Region: TrkA_C; pfam02080 393133003048 Predicted membrane protein [Function unknown]; Region: COG1289 393133003049 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393133003050 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 393133003051 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 393133003052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393133003053 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 393133003054 hypothetical protein; Provisional; Region: PRK13667 393133003055 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133003056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133003057 active site 393133003058 motif I; other site 393133003059 motif II; other site 393133003060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133003061 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133003062 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133003063 DNA binding site [nucleotide binding] 393133003064 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133003065 ligand binding site [chemical binding]; other site 393133003066 dimerization interface [polypeptide binding]; other site 393133003067 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 393133003068 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393133003069 trimer interface [polypeptide binding]; other site 393133003070 substrate binding site [chemical binding]; other site 393133003071 Mn binding site [ion binding]; other site 393133003072 transketolase; Reviewed; Region: PRK05899 393133003073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393133003074 TPP-binding site [chemical binding]; other site 393133003075 dimer interface [polypeptide binding]; other site 393133003076 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 393133003077 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393133003078 PYR/PP interface [polypeptide binding]; other site 393133003079 dimer interface [polypeptide binding]; other site 393133003080 TPP binding site [chemical binding]; other site 393133003081 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133003082 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 393133003083 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 393133003084 N- and C-terminal domain interface [polypeptide binding]; other site 393133003085 active site 393133003086 MgATP binding site [chemical binding]; other site 393133003087 catalytic site [active] 393133003088 metal binding site [ion binding]; metal-binding site 393133003089 putative glycerol binding site [chemical binding]; other site 393133003090 putative homotetramer interface [polypeptide binding]; other site 393133003091 putative homodimer interface [polypeptide binding]; other site 393133003092 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393133003093 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133003094 active site turn [active] 393133003095 phosphorylation site [posttranslational modification] 393133003096 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133003097 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393133003098 HPr interaction site; other site 393133003099 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133003100 active site 393133003101 phosphorylation site [posttranslational modification] 393133003102 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 393133003103 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 393133003104 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 393133003105 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 393133003106 GTP binding site; other site 393133003107 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 393133003108 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 393133003109 Walker A/P-loop; other site 393133003110 ATP binding site [chemical binding]; other site 393133003111 Q-loop/lid; other site 393133003112 ABC transporter signature motif; other site 393133003113 Walker B; other site 393133003114 D-loop; other site 393133003115 H-loop/switch region; other site 393133003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133003117 dimer interface [polypeptide binding]; other site 393133003118 conserved gate region; other site 393133003119 putative PBP binding loops; other site 393133003120 ABC-ATPase subunit interface; other site 393133003121 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 393133003122 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 393133003123 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 393133003124 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 393133003125 dimer interface [polypeptide binding]; other site 393133003126 putative functional site; other site 393133003127 putative MPT binding site; other site 393133003128 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 393133003129 Walker A motif; other site 393133003130 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 393133003131 MoaE homodimer interface [polypeptide binding]; other site 393133003132 MoaD interaction [polypeptide binding]; other site 393133003133 active site residues [active] 393133003134 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 393133003135 MoaE interaction surface [polypeptide binding]; other site 393133003136 MoeB interaction surface [polypeptide binding]; other site 393133003137 thiocarboxylated glycine; other site 393133003138 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 393133003139 trimer interface [polypeptide binding]; other site 393133003140 dimer interface [polypeptide binding]; other site 393133003141 putative active site [active] 393133003142 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 393133003143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393133003144 FeS/SAM binding site; other site 393133003145 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 393133003146 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 393133003147 MPT binding site; other site 393133003148 trimer interface [polypeptide binding]; other site 393133003149 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 393133003150 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 393133003151 ATP binding site [chemical binding]; other site 393133003152 substrate interface [chemical binding]; other site 393133003153 Flavin Reductases; Region: FlaRed; cl00801 393133003154 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 393133003155 active site 393133003156 catalytic residues [active] 393133003157 metal binding site [ion binding]; metal-binding site 393133003158 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 393133003159 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 393133003160 TPP-binding site [chemical binding]; other site 393133003161 tetramer interface [polypeptide binding]; other site 393133003162 heterodimer interface [polypeptide binding]; other site 393133003163 phosphorylation loop region [posttranslational modification] 393133003164 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 393133003165 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 393133003166 alpha subunit interface [polypeptide binding]; other site 393133003167 TPP binding site [chemical binding]; other site 393133003168 heterodimer interface [polypeptide binding]; other site 393133003169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133003170 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 393133003171 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393133003172 E3 interaction surface; other site 393133003173 lipoyl attachment site [posttranslational modification]; other site 393133003174 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393133003175 E3 interaction surface; other site 393133003176 lipoyl attachment site [posttranslational modification]; other site 393133003177 e3 binding domain; Region: E3_binding; pfam02817 393133003178 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393133003179 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 393133003180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393133003181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133003182 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393133003183 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 393133003184 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 393133003185 NAD(P) binding site [chemical binding]; other site 393133003186 LDH/MDH dimer interface [polypeptide binding]; other site 393133003187 substrate binding site [chemical binding]; other site 393133003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 393133003189 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 393133003190 Thioredoxin; Region: Thioredoxin_4; pfam13462 393133003191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133003193 active site 393133003194 phosphorylation site [posttranslational modification] 393133003195 intermolecular recognition site; other site 393133003196 dimerization interface [polypeptide binding]; other site 393133003197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133003198 DNA binding site [nucleotide binding] 393133003199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393133003200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133003201 dimerization interface [polypeptide binding]; other site 393133003202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133003203 dimer interface [polypeptide binding]; other site 393133003204 phosphorylation site [posttranslational modification] 393133003205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133003206 ATP binding site [chemical binding]; other site 393133003207 Mg2+ binding site [ion binding]; other site 393133003208 G-X-G motif; other site 393133003209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133003210 FtsX-like permease family; Region: FtsX; pfam02687 393133003211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133003212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133003213 Walker A/P-loop; other site 393133003214 ATP binding site [chemical binding]; other site 393133003215 Q-loop/lid; other site 393133003216 ABC transporter signature motif; other site 393133003217 Walker B; other site 393133003218 D-loop; other site 393133003219 H-loop/switch region; other site 393133003220 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 393133003221 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393133003222 Cl binding site [ion binding]; other site 393133003223 oligomer interface [polypeptide binding]; other site 393133003224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 393133003225 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 393133003226 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 393133003227 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 393133003228 active site 393133003229 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 393133003230 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 393133003231 G1 box; other site 393133003232 putative GEF interaction site [polypeptide binding]; other site 393133003233 GTP/Mg2+ binding site [chemical binding]; other site 393133003234 Switch I region; other site 393133003235 G2 box; other site 393133003236 G3 box; other site 393133003237 Switch II region; other site 393133003238 G4 box; other site 393133003239 G5 box; other site 393133003240 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 393133003241 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 393133003242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 393133003243 hypothetical protein; Provisional; Region: PRK13666 393133003244 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393133003245 pyruvate carboxylase; Reviewed; Region: PRK12999 393133003246 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393133003247 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393133003248 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 393133003249 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 393133003250 active site 393133003251 catalytic residues [active] 393133003252 metal binding site [ion binding]; metal-binding site 393133003253 homodimer binding site [polypeptide binding]; other site 393133003254 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 393133003255 carboxyltransferase (CT) interaction site; other site 393133003256 biotinylation site [posttranslational modification]; other site 393133003257 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 393133003258 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 393133003259 putative binding site residues; other site 393133003260 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 393133003261 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393133003262 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 393133003263 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 393133003264 Walker A/P-loop; other site 393133003265 ATP binding site [chemical binding]; other site 393133003266 Q-loop/lid; other site 393133003267 ABC transporter signature motif; other site 393133003268 Walker B; other site 393133003269 D-loop; other site 393133003270 H-loop/switch region; other site 393133003271 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133003272 SH3-like domain; Region: SH3_8; pfam13457 393133003273 SH3-like domain; Region: SH3_8; pfam13457 393133003274 SH3-like domain; Region: SH3_8; pfam13457 393133003275 SH3-like domain; Region: SH3_8; pfam13457 393133003276 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393133003277 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 393133003278 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 393133003279 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 393133003280 active site 393133003281 tetramer interface; other site 393133003282 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 393133003283 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 393133003284 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 393133003285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393133003286 active site 393133003287 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 393133003288 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 393133003289 substrate binding site; other site 393133003290 tetramer interface; other site 393133003291 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 393133003292 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 393133003293 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 393133003294 NAD binding site [chemical binding]; other site 393133003295 substrate binding site [chemical binding]; other site 393133003296 homodimer interface [polypeptide binding]; other site 393133003297 active site 393133003298 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 393133003299 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 393133003300 NADP binding site [chemical binding]; other site 393133003301 active site 393133003302 putative substrate binding site [chemical binding]; other site 393133003303 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393133003304 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 393133003305 substrate binding site; other site 393133003306 dimer interface; other site 393133003307 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 393133003308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393133003309 putative NAD(P) binding site [chemical binding]; other site 393133003310 putative catalytic Zn binding site [ion binding]; other site 393133003311 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393133003312 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 393133003313 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 393133003314 active site 393133003315 putative glycosyl transferase; Provisional; Region: PRK10073 393133003316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393133003317 active site 393133003318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393133003319 active site 393133003320 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 393133003321 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 393133003322 active site 393133003323 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 393133003324 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 393133003325 homodimer interface [polypeptide binding]; other site 393133003326 NAD binding pocket [chemical binding]; other site 393133003327 ATP binding pocket [chemical binding]; other site 393133003328 Mg binding site [ion binding]; other site 393133003329 active-site loop [active] 393133003330 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393133003331 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 393133003332 active site 393133003333 P-loop; other site 393133003334 phosphorylation site [posttranslational modification] 393133003335 GMP synthase; Reviewed; Region: guaA; PRK00074 393133003336 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 393133003337 AMP/PPi binding site [chemical binding]; other site 393133003338 candidate oxyanion hole; other site 393133003339 catalytic triad [active] 393133003340 potential glutamine specificity residues [chemical binding]; other site 393133003341 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 393133003342 ATP Binding subdomain [chemical binding]; other site 393133003343 Dimerization subdomain; other site 393133003344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003345 Helix-turn-helix domain; Region: HTH_18; pfam12833 393133003346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003347 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 393133003348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133003349 active site 393133003350 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 393133003351 LXG domain of WXG superfamily; Region: LXG; pfam04740 393133003352 LXG domain of WXG superfamily; Region: LXG; pfam04740 393133003353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393133003354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393133003355 MepB protein; Region: MepB; cl01985 393133003356 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 393133003357 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133003358 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133003359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133003360 Coenzyme A binding pocket [chemical binding]; other site 393133003361 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133003362 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 393133003363 DNA binding residues [nucleotide binding] 393133003364 drug binding residues [chemical binding]; other site 393133003365 dimer interface [polypeptide binding]; other site 393133003366 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 393133003367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133003368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133003369 Walker A/P-loop; other site 393133003370 ATP binding site [chemical binding]; other site 393133003371 Q-loop/lid; other site 393133003372 ABC transporter signature motif; other site 393133003373 Walker B; other site 393133003374 D-loop; other site 393133003375 H-loop/switch region; other site 393133003376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133003377 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133003379 Walker A/P-loop; other site 393133003380 ATP binding site [chemical binding]; other site 393133003381 Q-loop/lid; other site 393133003382 ABC transporter signature motif; other site 393133003383 Walker B; other site 393133003384 D-loop; other site 393133003385 H-loop/switch region; other site 393133003386 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 393133003387 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133003388 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133003389 DNA binding residues [nucleotide binding] 393133003390 putative dimer interface [polypeptide binding]; other site 393133003391 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133003392 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 393133003393 LRR adjacent; Region: LRR_adjacent; pfam08191 393133003394 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133003395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 393133003396 Clp protease; Region: CLP_protease; pfam00574 393133003397 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 393133003398 oligomer interface [polypeptide binding]; other site 393133003399 active site residues [active] 393133003400 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393133003401 dimer interface [polypeptide binding]; other site 393133003402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133003403 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 393133003404 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 393133003405 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 393133003406 SLBB domain; Region: SLBB; pfam10531 393133003407 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 393133003408 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 393133003409 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003410 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 393133003411 putative hexamer interface [polypeptide binding]; other site 393133003412 putative hexagonal pore; other site 393133003413 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 393133003414 putative hexamer interface [polypeptide binding]; other site 393133003415 putative hexagonal pore; other site 393133003416 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 393133003417 putative hexamer interface [polypeptide binding]; other site 393133003418 putative hexagonal pore; other site 393133003419 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 393133003420 G1 box; other site 393133003421 GTP/Mg2+ binding site [chemical binding]; other site 393133003422 G2 box; other site 393133003423 Switch I region; other site 393133003424 G3 box; other site 393133003425 Switch II region; other site 393133003426 G4 box; other site 393133003427 G5 box; other site 393133003428 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 393133003429 homotrimer interface [polypeptide binding]; other site 393133003430 Walker A motif; other site 393133003431 GTP binding site [chemical binding]; other site 393133003432 Walker B motif; other site 393133003433 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 393133003434 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133003435 catalytic core [active] 393133003436 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 393133003437 Sensory domain found in PocR; Region: PocR; pfam10114 393133003438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003439 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133003440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003441 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003442 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393133003443 Hexamer interface [polypeptide binding]; other site 393133003444 Hexagonal pore residue; other site 393133003445 propanediol utilization protein PduB; Provisional; Region: PRK15415 393133003446 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 393133003447 putative hexamer interface [polypeptide binding]; other site 393133003448 putative hexagonal pore; other site 393133003449 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 393133003450 putative hexamer interface [polypeptide binding]; other site 393133003451 putative hexagonal pore; other site 393133003452 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 393133003453 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 393133003454 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 393133003455 alpha-beta subunit interface [polypeptide binding]; other site 393133003456 alpha-gamma subunit interface [polypeptide binding]; other site 393133003457 active site 393133003458 substrate and K+ binding site; other site 393133003459 K+ binding site [ion binding]; other site 393133003460 cobalamin binding site [chemical binding]; other site 393133003461 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 393133003462 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 393133003463 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 393133003464 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 393133003465 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003466 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 393133003467 putative hexamer interface [polypeptide binding]; other site 393133003468 putative hexagonal pore; other site 393133003469 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003470 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393133003471 Hexamer interface [polypeptide binding]; other site 393133003472 Hexagonal pore residue; other site 393133003473 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 393133003474 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393133003475 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393133003476 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 393133003477 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133003478 nucleotide binding site [chemical binding]; other site 393133003479 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393133003480 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 393133003481 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 393133003482 Hexamer/Pentamer interface [polypeptide binding]; other site 393133003483 central pore; other site 393133003484 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 393133003485 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 393133003486 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 393133003487 putative catalytic cysteine [active] 393133003488 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 393133003489 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 393133003490 putative active site [active] 393133003491 metal binding site [ion binding]; metal-binding site 393133003492 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 393133003493 amphipathic channel; other site 393133003494 Asn-Pro-Ala signature motifs; other site 393133003495 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 393133003496 propionate/acetate kinase; Provisional; Region: PRK12379 393133003497 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 393133003498 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133003499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133003500 homodimer interface [polypeptide binding]; other site 393133003501 catalytic residue [active] 393133003502 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 393133003503 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 393133003504 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 393133003505 putative active site [active] 393133003506 metal binding site [ion binding]; metal-binding site 393133003507 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 393133003508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133003509 active site 393133003510 phosphorylation site [posttranslational modification] 393133003511 intermolecular recognition site; other site 393133003512 dimerization interface [polypeptide binding]; other site 393133003513 ANTAR domain; Region: ANTAR; pfam03861 393133003514 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 393133003515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 393133003516 Histidine kinase; Region: HisKA_2; pfam07568 393133003517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133003518 ATP binding site [chemical binding]; other site 393133003519 Mg2+ binding site [ion binding]; other site 393133003520 G-X-G motif; other site 393133003521 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 393133003522 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 393133003523 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 393133003524 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 393133003525 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 393133003526 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 393133003527 putative hexamer interface [polypeptide binding]; other site 393133003528 putative hexagonal pore; other site 393133003529 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 393133003530 putative hexamer interface [polypeptide binding]; other site 393133003531 putative hexagonal pore; other site 393133003532 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003533 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393133003534 Hexamer interface [polypeptide binding]; other site 393133003535 Hexagonal pore residue; other site 393133003536 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 393133003537 putative catalytic cysteine [active] 393133003538 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393133003539 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 393133003540 Hexamer interface [polypeptide binding]; other site 393133003541 Putative hexagonal pore residue; other site 393133003542 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 393133003543 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 393133003544 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393133003545 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393133003546 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 393133003547 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 393133003548 Hexamer/Pentamer interface [polypeptide binding]; other site 393133003549 central pore; other site 393133003550 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 393133003551 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 393133003552 putative hexamer interface [polypeptide binding]; other site 393133003553 putative hexagonal pore; other site 393133003554 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 393133003555 putative hexamer interface [polypeptide binding]; other site 393133003556 putative hexagonal pore; other site 393133003557 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 393133003558 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 393133003559 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 393133003560 hypothetical protein; Region: PHA01818 393133003561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133003563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133003564 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 393133003565 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 393133003566 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 393133003567 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 393133003568 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 393133003569 catalytic triad [active] 393133003570 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 393133003571 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 393133003572 Precorrin-8X methylmutase; Region: CbiC; pfam02570 393133003573 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 393133003574 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 393133003575 active site 393133003576 putative homodimer interface [polypeptide binding]; other site 393133003577 SAM binding site [chemical binding]; other site 393133003578 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 393133003579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133003580 S-adenosylmethionine binding site [chemical binding]; other site 393133003581 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 393133003582 active site 393133003583 SAM binding site [chemical binding]; other site 393133003584 homodimer interface [polypeptide binding]; other site 393133003585 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 393133003586 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 393133003587 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 393133003588 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 393133003589 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 393133003590 active site 393133003591 SAM binding site [chemical binding]; other site 393133003592 homodimer interface [polypeptide binding]; other site 393133003593 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 393133003594 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 393133003595 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 393133003596 active site 393133003597 SAM binding site [chemical binding]; other site 393133003598 homodimer interface [polypeptide binding]; other site 393133003599 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 393133003600 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 393133003601 active site 393133003602 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 393133003603 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 393133003604 active site 393133003605 C-terminal domain interface [polypeptide binding]; other site 393133003606 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 393133003607 active site 393133003608 N-terminal domain interface [polypeptide binding]; other site 393133003609 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 393133003610 active site 393133003611 SAM binding site [chemical binding]; other site 393133003612 homodimer interface [polypeptide binding]; other site 393133003613 cobalt transport protein CbiM; Validated; Region: PRK08319 393133003614 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 393133003615 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 393133003616 cobalt transport protein CbiQ; Provisional; Region: PRK15485 393133003617 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 393133003618 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393133003619 Walker A/P-loop; other site 393133003620 ATP binding site [chemical binding]; other site 393133003621 Q-loop/lid; other site 393133003622 ABC transporter signature motif; other site 393133003623 Walker B; other site 393133003624 D-loop; other site 393133003625 H-loop/switch region; other site 393133003626 cobyric acid synthase; Provisional; Region: PRK00784 393133003627 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393133003628 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393133003629 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 393133003630 catalytic triad [active] 393133003631 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 393133003632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 393133003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 393133003634 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 393133003635 AAA domain; Region: AAA_17; pfam13207 393133003636 Predicted transcriptional regulators [Transcription]; Region: COG1695 393133003637 Transcriptional regulator PadR-like family; Region: PadR; cl17335 393133003638 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 393133003639 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133003640 SH3-like domain; Region: SH3_8; pfam13457 393133003641 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133003642 SH3-like domain; Region: SH3_8; pfam13457 393133003643 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393133003644 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 393133003645 oligomer interface [polypeptide binding]; other site 393133003646 active site 393133003647 metal binding site [ion binding]; metal-binding site 393133003648 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 393133003649 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 393133003650 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393133003651 Predicted transcriptional regulators [Transcription]; Region: COG1733 393133003652 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 393133003653 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 393133003654 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 393133003655 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 393133003656 dimer interface [polypeptide binding]; other site 393133003657 motif 1; other site 393133003658 active site 393133003659 motif 2; other site 393133003660 motif 3; other site 393133003661 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 393133003662 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 393133003663 putative tRNA-binding site [nucleotide binding]; other site 393133003664 B3/4 domain; Region: B3_4; pfam03483 393133003665 tRNA synthetase B5 domain; Region: B5; smart00874 393133003666 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 393133003667 dimer interface [polypeptide binding]; other site 393133003668 motif 1; other site 393133003669 motif 3; other site 393133003670 motif 2; other site 393133003671 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 393133003672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133003673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133003674 Walker A/P-loop; other site 393133003675 ATP binding site [chemical binding]; other site 393133003676 Q-loop/lid; other site 393133003677 ABC transporter signature motif; other site 393133003678 Walker B; other site 393133003679 D-loop; other site 393133003680 H-loop/switch region; other site 393133003681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133003682 FtsX-like permease family; Region: FtsX; pfam02687 393133003683 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 393133003684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133003685 FtsX-like permease family; Region: FtsX; pfam02687 393133003686 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393133003687 MarR family; Region: MarR_2; pfam12802 393133003688 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 393133003689 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 393133003690 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 393133003691 ligand binding site [chemical binding]; other site 393133003692 active site 393133003693 UGI interface [polypeptide binding]; other site 393133003694 catalytic site [active] 393133003695 ribonuclease HIII; Provisional; Region: PRK00996 393133003696 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 393133003697 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 393133003698 RNA/DNA hybrid binding site [nucleotide binding]; other site 393133003699 active site 393133003700 Cell division protein ZapA; Region: ZapA; cl01146 393133003701 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 393133003702 Colicin V production protein; Region: Colicin_V; pfam02674 393133003703 hypothetical protein; Provisional; Region: PRK08609 393133003704 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 393133003705 active site 393133003706 primer binding site [nucleotide binding]; other site 393133003707 NTP binding site [chemical binding]; other site 393133003708 metal binding triad [ion binding]; metal-binding site 393133003709 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 393133003710 active site 393133003711 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 393133003712 MutS domain III; Region: MutS_III; pfam05192 393133003713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133003714 Walker A/P-loop; other site 393133003715 ATP binding site [chemical binding]; other site 393133003716 Q-loop/lid; other site 393133003717 ABC transporter signature motif; other site 393133003718 Walker B; other site 393133003719 D-loop; other site 393133003720 H-loop/switch region; other site 393133003721 Smr domain; Region: Smr; pfam01713 393133003722 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133003723 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393133003724 catalytic residues [active] 393133003725 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 393133003726 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 393133003727 GIY-YIG motif/motif A; other site 393133003728 active site 393133003729 catalytic site [active] 393133003730 putative DNA binding site [nucleotide binding]; other site 393133003731 metal binding site [ion binding]; metal-binding site 393133003732 UvrB/uvrC motif; Region: UVR; pfam02151 393133003733 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 393133003734 aspartate kinase; Reviewed; Region: PRK06635 393133003735 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 393133003736 putative nucleotide binding site [chemical binding]; other site 393133003737 putative catalytic residues [active] 393133003738 putative Mg ion binding site [ion binding]; other site 393133003739 putative aspartate binding site [chemical binding]; other site 393133003740 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 393133003741 putative allosteric regulatory site; other site 393133003742 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 393133003743 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 393133003744 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 393133003745 ribonuclease PH; Reviewed; Region: rph; PRK00173 393133003746 Ribonuclease PH; Region: RNase_PH_bact; cd11362 393133003747 hexamer interface [polypeptide binding]; other site 393133003748 active site 393133003749 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 393133003750 active site 393133003751 dimerization interface [polypeptide binding]; other site 393133003752 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 393133003753 active site 393133003754 metal binding site [ion binding]; metal-binding site 393133003755 homotetramer interface [polypeptide binding]; other site 393133003756 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393133003757 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393133003758 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 393133003759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 393133003760 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 393133003761 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 393133003762 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393133003763 dimer interface [polypeptide binding]; other site 393133003764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133003765 catalytic core [active] 393133003766 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 393133003767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393133003768 ATP binding site [chemical binding]; other site 393133003769 Mg++ binding site [ion binding]; other site 393133003770 motif III; other site 393133003771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133003772 nucleotide binding region [chemical binding]; other site 393133003773 ATP-binding site [chemical binding]; other site 393133003774 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 393133003775 RNA binding site [nucleotide binding]; other site 393133003776 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393133003777 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 393133003778 putative active site [active] 393133003779 nucleotide binding site [chemical binding]; other site 393133003780 nudix motif; other site 393133003781 putative metal binding site [ion binding]; other site 393133003782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133003783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133003784 putative substrate translocation pore; other site 393133003785 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133003786 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133003787 ligand binding site [chemical binding]; other site 393133003788 flexible hinge region; other site 393133003789 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133003790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393133003791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133003792 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133003793 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 393133003794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133003795 DNA-binding site [nucleotide binding]; DNA binding site 393133003796 UTRA domain; Region: UTRA; pfam07702 393133003797 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393133003798 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393133003799 Ca binding site [ion binding]; other site 393133003800 active site 393133003801 catalytic site [active] 393133003802 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 393133003803 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133003804 active site turn [active] 393133003805 phosphorylation site [posttranslational modification] 393133003806 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133003807 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 393133003808 nudix motif; other site 393133003809 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 393133003810 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133003811 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 393133003812 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 393133003813 putative catalytic cysteine [active] 393133003814 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 393133003815 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 393133003816 nucleotide binding site [chemical binding]; other site 393133003817 homotetrameric interface [polypeptide binding]; other site 393133003818 putative phosphate binding site [ion binding]; other site 393133003819 putative allosteric binding site; other site 393133003820 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 393133003821 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 393133003822 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133003823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133003824 non-specific DNA binding site [nucleotide binding]; other site 393133003825 salt bridge; other site 393133003826 sequence-specific DNA binding site [nucleotide binding]; other site 393133003827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133003828 non-specific DNA binding site [nucleotide binding]; other site 393133003829 salt bridge; other site 393133003830 sequence-specific DNA binding site [nucleotide binding]; other site 393133003831 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 393133003832 active site 393133003833 trigger factor; Provisional; Region: tig; PRK01490 393133003834 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 393133003835 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 393133003836 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 393133003837 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 393133003838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133003839 Walker A motif; other site 393133003840 ATP binding site [chemical binding]; other site 393133003841 Walker B motif; other site 393133003842 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393133003843 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 393133003844 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393133003845 Catalytic site [active] 393133003846 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393133003847 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 393133003848 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393133003849 Catalytic site [active] 393133003850 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393133003851 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 393133003852 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393133003853 Catalytic site [active] 393133003854 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393133003855 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 393133003856 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 393133003857 GTP/Mg2+ binding site [chemical binding]; other site 393133003858 G4 box; other site 393133003859 G5 box; other site 393133003860 G1 box; other site 393133003861 Switch I region; other site 393133003862 G2 box; other site 393133003863 G3 box; other site 393133003864 Switch II region; other site 393133003865 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 393133003866 RNA/DNA hybrid binding site [nucleotide binding]; other site 393133003867 active site 393133003868 DNA protecting protein DprA; Region: dprA; TIGR00732 393133003869 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 393133003870 DNA topoisomerase I; Validated; Region: PRK05582 393133003871 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 393133003872 active site 393133003873 interdomain interaction site; other site 393133003874 putative metal-binding site [ion binding]; other site 393133003875 nucleotide binding site [chemical binding]; other site 393133003876 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 393133003877 domain I; other site 393133003878 DNA binding groove [nucleotide binding] 393133003879 phosphate binding site [ion binding]; other site 393133003880 domain II; other site 393133003881 domain III; other site 393133003882 nucleotide binding site [chemical binding]; other site 393133003883 catalytic site [active] 393133003884 domain IV; other site 393133003885 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393133003886 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393133003887 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 393133003888 Glucose inhibited division protein A; Region: GIDA; pfam01134 393133003889 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 393133003890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 393133003891 active site 393133003892 DNA binding site [nucleotide binding] 393133003893 Int/Topo IB signature motif; other site 393133003894 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 393133003895 active site 393133003896 HslU subunit interaction site [polypeptide binding]; other site 393133003897 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 393133003898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133003899 Walker A motif; other site 393133003900 ATP binding site [chemical binding]; other site 393133003901 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 393133003902 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393133003903 transcriptional repressor CodY; Validated; Region: PRK04158 393133003904 CodY GAF-like domain; Region: CodY; pfam06018 393133003905 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 393133003906 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 393133003907 active site 393133003908 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 393133003909 active site 393133003910 catalytic residues [active] 393133003911 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 393133003912 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 393133003913 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 393133003914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133003915 Mg2+ binding site [ion binding]; other site 393133003916 G-X-G motif; other site 393133003917 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393133003918 anchoring element; other site 393133003919 dimer interface [polypeptide binding]; other site 393133003920 ATP binding site [chemical binding]; other site 393133003921 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 393133003922 active site 393133003923 putative metal-binding site [ion binding]; other site 393133003924 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393133003925 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 393133003926 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393133003927 CAP-like domain; other site 393133003928 active site 393133003929 primary dimer interface [polypeptide binding]; other site 393133003930 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393133003931 S-ribosylhomocysteinase; Provisional; Region: PRK02260 393133003932 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133003933 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133003934 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 393133003935 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 393133003936 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 393133003937 catalytic triad [active] 393133003938 catalytic triad [active] 393133003939 oxyanion hole [active] 393133003940 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393133003941 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 393133003942 active site 393133003943 catalytic site [active] 393133003944 metal binding site [ion binding]; metal-binding site 393133003945 dimer interface [polypeptide binding]; other site 393133003946 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 393133003947 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 393133003948 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 393133003949 bacterial Hfq-like; Region: Hfq; cd01716 393133003950 hexamer interface [polypeptide binding]; other site 393133003951 Sm1 motif; other site 393133003952 RNA binding site [nucleotide binding]; other site 393133003953 Sm2 motif; other site 393133003954 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 393133003955 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 393133003956 HflX GTPase family; Region: HflX; cd01878 393133003957 G1 box; other site 393133003958 GTP/Mg2+ binding site [chemical binding]; other site 393133003959 Switch I region; other site 393133003960 G2 box; other site 393133003961 G3 box; other site 393133003962 Switch II region; other site 393133003963 G4 box; other site 393133003964 G5 box; other site 393133003965 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 393133003966 Aluminium resistance protein; Region: Alum_res; pfam06838 393133003967 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 393133003968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393133003969 DNA binding residues [nucleotide binding] 393133003970 putative dimer interface [polypeptide binding]; other site 393133003971 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 393133003972 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 393133003973 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 393133003974 arsenical pump membrane protein; Provisional; Region: PRK15445 393133003975 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 393133003976 transmembrane helices; other site 393133003977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393133003978 LexA repressor; Validated; Region: PRK00215 393133003979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133003980 putative DNA binding site [nucleotide binding]; other site 393133003981 putative Zn2+ binding site [ion binding]; other site 393133003982 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 393133003983 Catalytic site [active] 393133003984 cell division suppressor protein YneA; Provisional; Region: PRK14125 393133003985 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 393133003986 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 393133003987 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393133003988 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393133003989 TPP-binding site [chemical binding]; other site 393133003990 dimer interface [polypeptide binding]; other site 393133003991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393133003992 PYR/PP interface [polypeptide binding]; other site 393133003993 dimer interface [polypeptide binding]; other site 393133003994 TPP binding site [chemical binding]; other site 393133003995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133003996 hypothetical protein; Provisional; Region: PRK01844 393133003997 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 393133003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393133003999 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393133004000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133004001 S-adenosylmethionine binding site [chemical binding]; other site 393133004002 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 393133004003 ParB-like nuclease domain; Region: ParBc; pfam02195 393133004004 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 393133004005 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 393133004006 Active Sites [active] 393133004007 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 393133004008 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393133004009 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 393133004010 putative nucleotide binding site [chemical binding]; other site 393133004011 uridine monophosphate binding site [chemical binding]; other site 393133004012 homohexameric interface [polypeptide binding]; other site 393133004013 ribosome recycling factor; Reviewed; Region: frr; PRK00083 393133004014 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 393133004015 hinge region; other site 393133004016 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 393133004017 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 393133004018 catalytic residue [active] 393133004019 putative FPP diphosphate binding site; other site 393133004020 putative FPP binding hydrophobic cleft; other site 393133004021 dimer interface [polypeptide binding]; other site 393133004022 putative IPP diphosphate binding site; other site 393133004023 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 393133004024 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 393133004025 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 393133004026 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 393133004027 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 393133004028 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 393133004029 RIP metalloprotease RseP; Region: TIGR00054 393133004030 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 393133004031 active site 393133004032 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 393133004033 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 393133004034 protein binding site [polypeptide binding]; other site 393133004035 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 393133004036 putative substrate binding region [chemical binding]; other site 393133004037 prolyl-tRNA synthetase; Provisional; Region: PRK09194 393133004038 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 393133004039 dimer interface [polypeptide binding]; other site 393133004040 motif 1; other site 393133004041 active site 393133004042 motif 2; other site 393133004043 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 393133004044 putative deacylase active site [active] 393133004045 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393133004046 active site 393133004047 motif 3; other site 393133004048 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 393133004049 anticodon binding site; other site 393133004050 DNA polymerase III PolC; Validated; Region: polC; PRK00448 393133004051 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 393133004052 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 393133004053 generic binding surface II; other site 393133004054 generic binding surface I; other site 393133004055 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 393133004056 active site 393133004057 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 393133004058 active site 393133004059 catalytic site [active] 393133004060 substrate binding site [chemical binding]; other site 393133004061 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 393133004062 ribosome maturation protein RimP; Reviewed; Region: PRK00092 393133004063 Sm and related proteins; Region: Sm_like; cl00259 393133004064 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 393133004065 putative oligomer interface [polypeptide binding]; other site 393133004066 putative RNA binding site [nucleotide binding]; other site 393133004067 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 393133004068 NusA N-terminal domain; Region: NusA_N; pfam08529 393133004069 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 393133004070 RNA binding site [nucleotide binding]; other site 393133004071 homodimer interface [polypeptide binding]; other site 393133004072 NusA-like KH domain; Region: KH_5; pfam13184 393133004073 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 393133004074 G-X-X-G motif; other site 393133004075 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 393133004076 putative RNA binding cleft [nucleotide binding]; other site 393133004077 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 393133004078 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393133004079 translation initiation factor IF-2; Region: IF-2; TIGR00487 393133004080 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393133004081 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 393133004082 G1 box; other site 393133004083 putative GEF interaction site [polypeptide binding]; other site 393133004084 GTP/Mg2+ binding site [chemical binding]; other site 393133004085 Switch I region; other site 393133004086 G2 box; other site 393133004087 G3 box; other site 393133004088 Switch II region; other site 393133004089 G4 box; other site 393133004090 G5 box; other site 393133004091 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 393133004092 Translation-initiation factor 2; Region: IF-2; pfam11987 393133004093 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 393133004094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 393133004095 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 393133004096 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 393133004097 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 393133004098 RNA binding site [nucleotide binding]; other site 393133004099 active site 393133004100 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 393133004101 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 393133004102 active site 393133004103 Riboflavin kinase; Region: Flavokinase; smart00904 393133004104 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 393133004105 16S/18S rRNA binding site [nucleotide binding]; other site 393133004106 S13e-L30e interaction site [polypeptide binding]; other site 393133004107 25S rRNA binding site [nucleotide binding]; other site 393133004108 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 393133004109 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 393133004110 RNase E interface [polypeptide binding]; other site 393133004111 trimer interface [polypeptide binding]; other site 393133004112 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 393133004113 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 393133004114 RNase E interface [polypeptide binding]; other site 393133004115 trimer interface [polypeptide binding]; other site 393133004116 active site 393133004117 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 393133004118 putative nucleic acid binding region [nucleotide binding]; other site 393133004119 G-X-X-G motif; other site 393133004120 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 393133004121 RNA binding site [nucleotide binding]; other site 393133004122 domain interface; other site 393133004123 GTPase RsgA; Reviewed; Region: PRK01889 393133004124 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393133004125 RNA binding site [nucleotide binding]; other site 393133004126 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 393133004127 GTPase/Zn-binding domain interface [polypeptide binding]; other site 393133004128 GTP/Mg2+ binding site [chemical binding]; other site 393133004129 G4 box; other site 393133004130 G5 box; other site 393133004131 G1 box; other site 393133004132 Switch I region; other site 393133004133 G2 box; other site 393133004134 G3 box; other site 393133004135 Switch II region; other site 393133004136 YceG-like family; Region: YceG; pfam02618 393133004137 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 393133004138 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 393133004139 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 393133004140 Rhomboid family; Region: Rhomboid; pfam01694 393133004141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133004142 TPR motif; other site 393133004143 TPR repeat; Region: TPR_11; pfam13414 393133004144 binding surface 393133004145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 393133004146 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 393133004147 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133004148 nucleotide binding site [chemical binding]; other site 393133004149 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 393133004150 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 393133004151 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 393133004152 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 393133004153 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393133004154 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393133004155 Type II/IV secretion system protein; Region: T2SE; pfam00437 393133004156 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393133004157 Walker A motif; other site 393133004158 ATP binding site [chemical binding]; other site 393133004159 Walker B motif; other site 393133004160 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 393133004161 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 393133004162 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 393133004163 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 393133004164 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393133004165 tetramer interface [polypeptide binding]; other site 393133004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133004167 catalytic residue [active] 393133004168 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393133004169 tetramer interface [polypeptide binding]; other site 393133004170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133004171 catalytic residue [active] 393133004172 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393133004173 active site residue [active] 393133004174 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 393133004175 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 393133004176 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 393133004177 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 393133004178 active site 393133004179 elongation factor P; Validated; Region: PRK00529 393133004180 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 393133004181 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 393133004182 RNA binding site [nucleotide binding]; other site 393133004183 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 393133004184 RNA binding site [nucleotide binding]; other site 393133004185 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 393133004186 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 393133004187 carboxyltransferase (CT) interaction site; other site 393133004188 biotinylation site [posttranslational modification]; other site 393133004189 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 393133004190 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393133004191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393133004192 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 393133004193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 393133004194 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 393133004195 putative RNA binding site [nucleotide binding]; other site 393133004196 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 393133004197 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 393133004198 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 393133004199 homodimer interface [polypeptide binding]; other site 393133004200 NADP binding site [chemical binding]; other site 393133004201 substrate binding site [chemical binding]; other site 393133004202 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 393133004203 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 393133004204 generic binding surface II; other site 393133004205 generic binding surface I; other site 393133004206 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 393133004207 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393133004208 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393133004209 substrate binding pocket [chemical binding]; other site 393133004210 chain length determination region; other site 393133004211 substrate-Mg2+ binding site; other site 393133004212 catalytic residues [active] 393133004213 aspartate-rich region 1; other site 393133004214 active site lid residues [active] 393133004215 aspartate-rich region 2; other site 393133004216 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393133004217 DNA-binding site [nucleotide binding]; DNA binding site 393133004218 RNA-binding motif; other site 393133004219 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 393133004220 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 393133004221 TPP-binding site; other site 393133004222 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393133004223 PYR/PP interface [polypeptide binding]; other site 393133004224 dimer interface [polypeptide binding]; other site 393133004225 TPP binding site [chemical binding]; other site 393133004226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133004227 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 393133004228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133004229 RNA binding surface [nucleotide binding]; other site 393133004230 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 393133004231 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 393133004232 arginine repressor; Provisional; Region: PRK04280 393133004233 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 393133004234 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 393133004235 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393133004236 Walker A/P-loop; other site 393133004237 ATP binding site [chemical binding]; other site 393133004238 Q-loop/lid; other site 393133004239 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393133004240 ABC transporter signature motif; other site 393133004241 Walker B; other site 393133004242 D-loop; other site 393133004243 H-loop/switch region; other site 393133004244 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 393133004245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133004246 nucleotide binding site [chemical binding]; other site 393133004247 Acetokinase family; Region: Acetate_kinase; cl17229 393133004248 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 393133004249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133004250 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393133004251 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 393133004252 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 393133004253 tetramer interface [polypeptide binding]; other site 393133004254 TPP-binding site [chemical binding]; other site 393133004255 heterodimer interface [polypeptide binding]; other site 393133004256 phosphorylation loop region [posttranslational modification] 393133004257 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 393133004258 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 393133004259 alpha subunit interface [polypeptide binding]; other site 393133004260 TPP binding site [chemical binding]; other site 393133004261 heterodimer interface [polypeptide binding]; other site 393133004262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393133004263 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 393133004264 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393133004265 E3 interaction surface; other site 393133004266 lipoyl attachment site [posttranslational modification]; other site 393133004267 e3 binding domain; Region: E3_binding; pfam02817 393133004268 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393133004269 peptidase T-like protein; Region: PepT-like; TIGR01883 393133004270 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 393133004271 metal binding site [ion binding]; metal-binding site 393133004272 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 393133004273 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 393133004274 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 393133004275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133004277 active site 393133004278 phosphorylation site [posttranslational modification] 393133004279 intermolecular recognition site; other site 393133004280 dimerization interface [polypeptide binding]; other site 393133004281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133004282 DNA binding site [nucleotide binding] 393133004283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393133004284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133004285 dimerization interface [polypeptide binding]; other site 393133004286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133004287 dimer interface [polypeptide binding]; other site 393133004288 phosphorylation site [posttranslational modification] 393133004289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133004290 ATP binding site [chemical binding]; other site 393133004291 Mg2+ binding site [ion binding]; other site 393133004292 G-X-G motif; other site 393133004293 OxaA-like protein precursor; Validated; Region: PRK01622 393133004294 acylphosphatase; Provisional; Region: PRK14443 393133004295 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 393133004296 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 393133004297 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 393133004298 homotetramer interface [polypeptide binding]; other site 393133004299 FMN binding site [chemical binding]; other site 393133004300 homodimer contacts [polypeptide binding]; other site 393133004301 putative active site [active] 393133004302 putative substrate binding site [chemical binding]; other site 393133004303 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 393133004304 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 393133004305 active site residue [active] 393133004306 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 393133004307 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393133004308 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133004309 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133004310 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 393133004311 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 393133004312 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393133004313 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 393133004314 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 393133004315 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 393133004316 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 393133004317 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 393133004318 ligand binding site [chemical binding]; other site 393133004319 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 393133004320 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 393133004321 Walker A/P-loop; other site 393133004322 ATP binding site [chemical binding]; other site 393133004323 Q-loop/lid; other site 393133004324 ABC transporter signature motif; other site 393133004325 Walker B; other site 393133004326 D-loop; other site 393133004327 H-loop/switch region; other site 393133004328 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 393133004329 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 393133004330 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 393133004331 TM-ABC transporter signature motif; other site 393133004332 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 393133004333 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 393133004334 TM-ABC transporter signature motif; other site 393133004335 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393133004336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393133004337 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393133004338 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 393133004339 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393133004340 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 393133004341 classical (c) SDRs; Region: SDR_c; cd05233 393133004342 NAD(P) binding site [chemical binding]; other site 393133004343 active site 393133004344 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 393133004345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133004346 non-specific DNA binding site [nucleotide binding]; other site 393133004347 salt bridge; other site 393133004348 sequence-specific DNA binding site [nucleotide binding]; other site 393133004349 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 393133004350 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 393133004351 competence damage-inducible protein A; Provisional; Region: PRK00549 393133004352 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 393133004353 putative MPT binding site; other site 393133004354 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 393133004355 recombinase A; Provisional; Region: recA; PRK09354 393133004356 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 393133004357 hexamer interface [polypeptide binding]; other site 393133004358 Walker A motif; other site 393133004359 ATP binding site [chemical binding]; other site 393133004360 Walker B motif; other site 393133004361 phosphodiesterase; Provisional; Region: PRK12704 393133004362 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133004363 Zn2+ binding site [ion binding]; other site 393133004364 Mg2+ binding site [ion binding]; other site 393133004365 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 393133004366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133004367 Coenzyme A binding pocket [chemical binding]; other site 393133004368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393133004369 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 393133004370 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393133004371 putative active site [active] 393133004372 metal binding site [ion binding]; metal-binding site 393133004373 homodimer binding site [polypeptide binding]; other site 393133004374 Predicted membrane protein [Function unknown]; Region: COG4550 393133004375 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 393133004376 MutS domain I; Region: MutS_I; pfam01624 393133004377 MutS domain II; Region: MutS_II; pfam05188 393133004378 MutS domain III; Region: MutS_III; pfam05192 393133004379 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 393133004380 Walker A/P-loop; other site 393133004381 ATP binding site [chemical binding]; other site 393133004382 Q-loop/lid; other site 393133004383 ABC transporter signature motif; other site 393133004384 Walker B; other site 393133004385 D-loop; other site 393133004386 H-loop/switch region; other site 393133004387 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 393133004388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133004389 ATP binding site [chemical binding]; other site 393133004390 Mg2+ binding site [ion binding]; other site 393133004391 G-X-G motif; other site 393133004392 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 393133004393 ATP binding site [chemical binding]; other site 393133004394 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 393133004395 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 393133004396 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 393133004397 Pyruvate formate lyase 1; Region: PFL1; cd01678 393133004398 coenzyme A binding site [chemical binding]; other site 393133004399 active site 393133004400 catalytic residues [active] 393133004401 glycine loop; other site 393133004402 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 393133004403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393133004404 FeS/SAM binding site; other site 393133004405 Predicted transcriptional regulators [Transcription]; Region: COG1695 393133004406 Transcriptional regulator PadR-like family; Region: PadR; cl17335 393133004407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133004408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133004409 putative substrate translocation pore; other site 393133004410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133004411 non-specific DNA binding site [nucleotide binding]; other site 393133004412 salt bridge; other site 393133004413 sequence-specific DNA binding site [nucleotide binding]; other site 393133004414 topology modulation protein; Provisional; Region: PRK07261 393133004415 AAA domain; Region: AAA_17; pfam13207 393133004416 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133004417 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133004418 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133004419 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133004420 putative acyltransferase; Provisional; Region: PRK05790 393133004421 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 393133004422 dimer interface [polypeptide binding]; other site 393133004423 active site 393133004424 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 393133004425 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 393133004426 dimer interface [polypeptide binding]; other site 393133004427 active site 393133004428 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393133004429 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 393133004430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133004431 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 393133004432 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 393133004433 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393133004434 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393133004435 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 393133004436 FAD binding domain; Region: FAD_binding_4; pfam01565 393133004437 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 393133004438 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 393133004439 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 393133004440 Walker A/P-loop; other site 393133004441 ATP binding site [chemical binding]; other site 393133004442 Q-loop/lid; other site 393133004443 ABC transporter signature motif; other site 393133004444 Walker B; other site 393133004445 D-loop; other site 393133004446 H-loop/switch region; other site 393133004447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393133004448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133004449 dimer interface [polypeptide binding]; other site 393133004450 conserved gate region; other site 393133004451 ABC-ATPase subunit interface; other site 393133004452 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 393133004453 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 393133004454 manganese transport protein MntH; Reviewed; Region: PRK00701 393133004455 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 393133004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133004457 dimer interface [polypeptide binding]; other site 393133004458 conserved gate region; other site 393133004459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 393133004460 ABC-ATPase subunit interface; other site 393133004461 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393133004462 LysR substrate binding domain; Region: LysR_substrate; pfam03466 393133004463 dimerization interface [polypeptide binding]; other site 393133004464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133004465 dimer interface [polypeptide binding]; other site 393133004466 conserved gate region; other site 393133004467 putative PBP binding loops; other site 393133004468 ABC-ATPase subunit interface; other site 393133004469 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 393133004470 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 393133004471 Walker A/P-loop; other site 393133004472 ATP binding site [chemical binding]; other site 393133004473 Q-loop/lid; other site 393133004474 ABC transporter signature motif; other site 393133004475 Walker B; other site 393133004476 D-loop; other site 393133004477 H-loop/switch region; other site 393133004478 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 393133004479 Predicted membrane protein [Function unknown]; Region: COG3859 393133004480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 393133004481 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 393133004482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133004483 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133004484 ABC transporter; Region: ABC_tran_2; pfam12848 393133004485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133004486 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 393133004487 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133004488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133004489 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393133004490 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 393133004491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133004492 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 393133004493 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 393133004494 dihydrodipicolinate synthase; Region: dapA; TIGR00674 393133004495 dimer interface [polypeptide binding]; other site 393133004496 active site 393133004497 catalytic residue [active] 393133004498 aspartate kinase I; Reviewed; Region: PRK08210 393133004499 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 393133004500 nucleotide binding site [chemical binding]; other site 393133004501 substrate binding site [chemical binding]; other site 393133004502 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 393133004503 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 393133004504 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 393133004505 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 393133004506 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 393133004507 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393133004508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393133004509 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 393133004510 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 393133004511 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 393133004512 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 393133004513 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 393133004514 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393133004515 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393133004516 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 393133004517 Predicted membrane protein [Function unknown]; Region: COG4392 393133004518 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 393133004519 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 393133004520 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393133004521 metal binding site 2 [ion binding]; metal-binding site 393133004522 putative DNA binding helix; other site 393133004523 metal binding site 1 [ion binding]; metal-binding site 393133004524 dimer interface [polypeptide binding]; other site 393133004525 structural Zn2+ binding site [ion binding]; other site 393133004526 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393133004527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133004528 ABC-ATPase subunit interface; other site 393133004529 dimer interface [polypeptide binding]; other site 393133004530 putative PBP binding regions; other site 393133004531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393133004532 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393133004533 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 393133004534 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393133004535 DHHA2 domain; Region: DHHA2; pfam02833 393133004536 endonuclease IV; Provisional; Region: PRK01060 393133004537 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 393133004538 AP (apurinic/apyrimidinic) site pocket; other site 393133004539 DNA interaction; other site 393133004540 Metal-binding active site; metal-binding site 393133004541 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393133004542 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393133004543 ATP binding site [chemical binding]; other site 393133004544 Mg++ binding site [ion binding]; other site 393133004545 motif III; other site 393133004546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133004547 nucleotide binding region [chemical binding]; other site 393133004548 ATP-binding site [chemical binding]; other site 393133004549 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 393133004550 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 393133004551 Uncharacterized conserved protein [Function unknown]; Region: COG0327 393133004552 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 393133004553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 393133004554 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 393133004555 Uncharacterized conserved protein [Function unknown]; Region: COG0327 393133004556 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 393133004557 Family of unknown function (DUF633); Region: DUF633; pfam04816 393133004558 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 393133004559 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 393133004560 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 393133004561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393133004562 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 393133004563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393133004564 DNA binding residues [nucleotide binding] 393133004565 DNA primase; Validated; Region: dnaG; PRK05667 393133004566 CHC2 zinc finger; Region: zf-CHC2; pfam01807 393133004567 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 393133004568 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 393133004569 active site 393133004570 metal binding site [ion binding]; metal-binding site 393133004571 interdomain interaction site; other site 393133004572 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 393133004573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 393133004574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 393133004575 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 393133004576 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 393133004577 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 393133004578 dimer interface [polypeptide binding]; other site 393133004579 motif 1; other site 393133004580 active site 393133004581 motif 2; other site 393133004582 motif 3; other site 393133004583 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 393133004584 Recombination protein O N terminal; Region: RecO_N; pfam11967 393133004585 Recombination protein O C terminal; Region: RecO_C; pfam02565 393133004586 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 393133004587 GTPase Era; Reviewed; Region: era; PRK00089 393133004588 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 393133004589 G1 box; other site 393133004590 GTP/Mg2+ binding site [chemical binding]; other site 393133004591 Switch I region; other site 393133004592 G2 box; other site 393133004593 Switch II region; other site 393133004594 G3 box; other site 393133004595 G4 box; other site 393133004596 G5 box; other site 393133004597 KH domain; Region: KH_2; pfam07650 393133004598 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 393133004599 active site 393133004600 catalytic motif [active] 393133004601 Zn binding site [ion binding]; other site 393133004602 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 393133004603 metal-binding heat shock protein; Provisional; Region: PRK00016 393133004604 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 393133004605 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 393133004606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133004607 Zn2+ binding site [ion binding]; other site 393133004608 Mg2+ binding site [ion binding]; other site 393133004609 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 393133004610 PhoH-like protein; Region: PhoH; pfam02562 393133004611 Yqey-like protein; Region: YqeY; pfam09424 393133004612 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 393133004613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 393133004614 RNA methyltransferase, RsmE family; Region: TIGR00046 393133004615 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 393133004616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133004617 S-adenosylmethionine binding site [chemical binding]; other site 393133004618 chaperone protein DnaJ; Provisional; Region: PRK14280 393133004619 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 393133004620 HSP70 interaction site [polypeptide binding]; other site 393133004621 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 393133004622 substrate binding site [polypeptide binding]; other site 393133004623 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 393133004624 Zn binding sites [ion binding]; other site 393133004625 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 393133004626 dimer interface [polypeptide binding]; other site 393133004627 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 393133004628 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 393133004629 nucleotide binding site [chemical binding]; other site 393133004630 NEF interaction site [polypeptide binding]; other site 393133004631 SBD interface [polypeptide binding]; other site 393133004632 heat shock protein GrpE; Provisional; Region: PRK14140 393133004633 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 393133004634 dimer interface [polypeptide binding]; other site 393133004635 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 393133004636 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 393133004637 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 393133004638 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 393133004639 HemN C-terminal domain; Region: HemN_C; pfam06969 393133004640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 393133004641 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 393133004642 NADP binding site [chemical binding]; other site 393133004643 putative substrate binding site [chemical binding]; other site 393133004644 active site 393133004645 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133004646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393133004647 DNA binding residues [nucleotide binding] 393133004648 putative dimer interface [polypeptide binding]; other site 393133004649 GTP-binding protein LepA; Provisional; Region: PRK05433 393133004650 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 393133004651 G1 box; other site 393133004652 putative GEF interaction site [polypeptide binding]; other site 393133004653 GTP/Mg2+ binding site [chemical binding]; other site 393133004654 Switch I region; other site 393133004655 G2 box; other site 393133004656 G3 box; other site 393133004657 Switch II region; other site 393133004658 G4 box; other site 393133004659 G5 box; other site 393133004660 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 393133004661 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 393133004662 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 393133004663 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 393133004664 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 393133004665 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 393133004666 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 393133004667 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 393133004668 Competence protein; Region: Competence; pfam03772 393133004669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133004670 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 393133004671 catalytic motif [active] 393133004672 Zn binding site [ion binding]; other site 393133004673 SLBB domain; Region: SLBB; pfam10531 393133004674 comEA protein; Region: comE; TIGR01259 393133004675 Helix-hairpin-helix motif; Region: HHH; pfam00633 393133004676 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393133004677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133004678 S-adenosylmethionine binding site [chemical binding]; other site 393133004679 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 393133004680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133004681 Zn2+ binding site [ion binding]; other site 393133004682 Mg2+ binding site [ion binding]; other site 393133004683 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 393133004684 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 393133004685 active site 393133004686 (T/H)XGH motif; other site 393133004687 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 393133004688 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 393133004689 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393133004690 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393133004691 shikimate binding site; other site 393133004692 NAD(P) binding site [chemical binding]; other site 393133004693 GTPase YqeH; Provisional; Region: PRK13796 393133004694 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 393133004695 GTP/Mg2+ binding site [chemical binding]; other site 393133004696 G4 box; other site 393133004697 G5 box; other site 393133004698 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 393133004699 G1 box; other site 393133004700 G1 box; other site 393133004701 GTP/Mg2+ binding site [chemical binding]; other site 393133004702 G2 box; other site 393133004703 Switch I region; other site 393133004704 G2 box; other site 393133004705 Switch I region; other site 393133004706 G3 box; other site 393133004707 G3 box; other site 393133004708 Switch II region; other site 393133004709 Switch II region; other site 393133004710 G4 box; other site 393133004711 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 393133004712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133004713 motif II; other site 393133004714 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 393133004715 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 393133004716 active site 393133004717 Zn binding site [ion binding]; other site 393133004718 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 393133004719 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 393133004720 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 393133004721 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 393133004722 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 393133004723 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 393133004724 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 393133004725 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 393133004726 Sugar specificity; other site 393133004727 Pyrimidine base specificity; other site 393133004728 ATP-binding site [chemical binding]; other site 393133004729 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 393133004730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133004731 S-adenosylmethionine binding site [chemical binding]; other site 393133004732 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 393133004733 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 393133004734 dimerization interface [polypeptide binding]; other site 393133004735 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393133004736 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393133004737 hypothetical protein; Provisional; Region: PRK13678 393133004738 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 393133004739 hypothetical protein; Provisional; Region: PRK05473 393133004740 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 393133004741 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 393133004742 motif 1; other site 393133004743 active site 393133004744 motif 2; other site 393133004745 motif 3; other site 393133004746 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393133004747 DHHA1 domain; Region: DHHA1; pfam02272 393133004748 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133004749 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133004750 Walker A/P-loop; other site 393133004751 ATP binding site [chemical binding]; other site 393133004752 Q-loop/lid; other site 393133004753 ABC transporter signature motif; other site 393133004754 Walker B; other site 393133004755 D-loop; other site 393133004756 H-loop/switch region; other site 393133004757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133004758 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393133004759 FtsX-like permease family; Region: FtsX; pfam02687 393133004760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133004761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133004762 active site 393133004763 phosphorylation site [posttranslational modification] 393133004764 intermolecular recognition site; other site 393133004765 dimerization interface [polypeptide binding]; other site 393133004766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133004767 DNA binding site [nucleotide binding] 393133004768 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 393133004769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133004770 dimerization interface [polypeptide binding]; other site 393133004771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133004772 dimer interface [polypeptide binding]; other site 393133004773 phosphorylation site [posttranslational modification] 393133004774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133004775 ATP binding site [chemical binding]; other site 393133004776 Mg2+ binding site [ion binding]; other site 393133004777 G-X-G motif; other site 393133004778 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 393133004779 AAA domain; Region: AAA_30; pfam13604 393133004780 Family description; Region: UvrD_C_2; pfam13538 393133004781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133004782 binding surface 393133004783 TPR motif; other site 393133004784 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 393133004785 TPR repeat; Region: TPR_11; pfam13414 393133004786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133004787 binding surface 393133004788 TPR motif; other site 393133004789 TPR repeat; Region: TPR_11; pfam13414 393133004790 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 393133004791 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 393133004792 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 393133004793 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393133004794 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393133004795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393133004796 catalytic residue [active] 393133004797 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 393133004798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133004799 Walker A motif; other site 393133004800 ATP binding site [chemical binding]; other site 393133004801 Walker B motif; other site 393133004802 arginine finger; other site 393133004803 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 393133004804 Predicted transcriptional regulator [Transcription]; Region: COG1959 393133004805 Transcriptional regulator; Region: Rrf2; pfam02082 393133004806 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 393133004807 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 393133004808 Nitrogen regulatory protein P-II; Region: P-II; smart00938 393133004809 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 393133004810 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 393133004811 dimer interface [polypeptide binding]; other site 393133004812 anticodon binding site; other site 393133004813 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 393133004814 homodimer interface [polypeptide binding]; other site 393133004815 motif 1; other site 393133004816 active site 393133004817 motif 2; other site 393133004818 GAD domain; Region: GAD; pfam02938 393133004819 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393133004820 active site 393133004821 motif 3; other site 393133004822 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 393133004823 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 393133004824 dimer interface [polypeptide binding]; other site 393133004825 motif 1; other site 393133004826 active site 393133004827 motif 2; other site 393133004828 motif 3; other site 393133004829 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 393133004830 anticodon binding site; other site 393133004831 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 393133004832 Bacterial SH3 domain; Region: SH3_3; pfam08239 393133004833 Bacterial SH3 domain; Region: SH3_3; pfam08239 393133004834 Bacterial SH3 domain homologues; Region: SH3b; smart00287 393133004835 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 393133004836 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 393133004837 active site 393133004838 metal binding site [ion binding]; metal-binding site 393133004839 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 393133004840 putative active site [active] 393133004841 dimerization interface [polypeptide binding]; other site 393133004842 putative tRNAtyr binding site [nucleotide binding]; other site 393133004843 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393133004844 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133004845 Zn2+ binding site [ion binding]; other site 393133004846 Mg2+ binding site [ion binding]; other site 393133004847 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393133004848 synthetase active site [active] 393133004849 NTP binding site [chemical binding]; other site 393133004850 metal binding site [ion binding]; metal-binding site 393133004851 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 393133004852 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 393133004853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133004854 active site 393133004855 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 393133004856 DHH family; Region: DHH; pfam01368 393133004857 DHHA1 domain; Region: DHHA1; pfam02272 393133004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 393133004859 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 393133004860 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 393133004861 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 393133004862 Protein export membrane protein; Region: SecD_SecF; cl14618 393133004863 Protein export membrane protein; Region: SecD_SecF; pfam02355 393133004864 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 393133004865 Preprotein translocase subunit; Region: YajC; pfam02699 393133004866 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 393133004867 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 393133004868 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 393133004869 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 393133004870 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 393133004871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133004872 Walker A motif; other site 393133004873 ATP binding site [chemical binding]; other site 393133004874 Walker B motif; other site 393133004875 arginine finger; other site 393133004876 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 393133004877 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 393133004878 RuvA N terminal domain; Region: RuvA_N; pfam01330 393133004879 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 393133004880 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393133004881 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133004882 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 393133004883 NAD binding site [chemical binding]; other site 393133004884 dimer interface [polypeptide binding]; other site 393133004885 substrate binding site [chemical binding]; other site 393133004886 hypothetical protein; Validated; Region: PRK00110 393133004887 prephenate dehydratase; Provisional; Region: PRK11898 393133004888 Prephenate dehydratase; Region: PDT; pfam00800 393133004889 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 393133004890 putative L-Phe binding site [chemical binding]; other site 393133004891 GTPase CgtA; Reviewed; Region: obgE; PRK12297 393133004892 GTP1/OBG; Region: GTP1_OBG; pfam01018 393133004893 Obg GTPase; Region: Obg; cd01898 393133004894 G1 box; other site 393133004895 GTP/Mg2+ binding site [chemical binding]; other site 393133004896 Switch I region; other site 393133004897 G2 box; other site 393133004898 G3 box; other site 393133004899 Switch II region; other site 393133004900 G4 box; other site 393133004901 G5 box; other site 393133004902 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 393133004903 glycerol kinase; Provisional; Region: glpK; PRK00047 393133004904 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 393133004905 N- and C-terminal domain interface [polypeptide binding]; other site 393133004906 active site 393133004907 MgATP binding site [chemical binding]; other site 393133004908 catalytic site [active] 393133004909 metal binding site [ion binding]; metal-binding site 393133004910 glycerol binding site [chemical binding]; other site 393133004911 homotetramer interface [polypeptide binding]; other site 393133004912 homodimer interface [polypeptide binding]; other site 393133004913 FBP binding site [chemical binding]; other site 393133004914 protein IIAGlc interface [polypeptide binding]; other site 393133004915 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 393133004916 amphipathic channel; other site 393133004917 Asn-Pro-Ala signature motifs; other site 393133004918 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 393133004919 hypothetical protein; Provisional; Region: PRK14553 393133004920 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 393133004921 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 393133004922 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 393133004923 homodimer interface [polypeptide binding]; other site 393133004924 oligonucleotide binding site [chemical binding]; other site 393133004925 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 393133004926 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 393133004927 Switch I; other site 393133004928 Switch II; other site 393133004929 septum formation inhibitor; Reviewed; Region: minC; PRK00513 393133004930 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 393133004931 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 393133004932 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 393133004933 Protein of unknown function (DUF972); Region: DUF972; pfam06156 393133004934 rod shape-determining protein MreC; Region: MreC; pfam04085 393133004935 rod shape-determining protein MreB; Provisional; Region: PRK13927 393133004936 MreB and similar proteins; Region: MreB_like; cd10225 393133004937 nucleotide binding site [chemical binding]; other site 393133004938 Mg binding site [ion binding]; other site 393133004939 putative protofilament interaction site [polypeptide binding]; other site 393133004940 RodZ interaction site [polypeptide binding]; other site 393133004941 hypothetical protein; Reviewed; Region: PRK00024 393133004942 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 393133004943 MPN+ (JAMM) motif; other site 393133004944 Zinc-binding site [ion binding]; other site 393133004945 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 393133004946 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 393133004947 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 393133004948 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393133004949 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393133004950 AAA domain; Region: AAA_14; pfam13173 393133004951 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 393133004952 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393133004953 active site 393133004954 HIGH motif; other site 393133004955 nucleotide binding site [chemical binding]; other site 393133004956 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393133004957 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 393133004958 active site 393133004959 KMSKS motif; other site 393133004960 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 393133004961 tRNA binding surface [nucleotide binding]; other site 393133004962 anticodon binding site; other site 393133004963 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 393133004964 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 393133004965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393133004966 inhibitor-cofactor binding pocket; inhibition site 393133004967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133004968 catalytic residue [active] 393133004969 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 393133004970 dimer interface [polypeptide binding]; other site 393133004971 active site 393133004972 Schiff base residues; other site 393133004973 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 393133004974 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 393133004975 active site 393133004976 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 393133004977 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 393133004978 domain interfaces; other site 393133004979 active site 393133004980 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 393133004981 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 393133004982 tRNA; other site 393133004983 putative tRNA binding site [nucleotide binding]; other site 393133004984 putative NADP binding site [chemical binding]; other site 393133004985 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 393133004986 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 393133004987 G1 box; other site 393133004988 GTP/Mg2+ binding site [chemical binding]; other site 393133004989 Switch I region; other site 393133004990 G2 box; other site 393133004991 G3 box; other site 393133004992 Switch II region; other site 393133004993 G4 box; other site 393133004994 G5 box; other site 393133004995 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 393133004996 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 393133004997 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393133004998 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 393133004999 active site 393133005000 dimer interface [polypeptide binding]; other site 393133005001 motif 1; other site 393133005002 motif 2; other site 393133005003 motif 3; other site 393133005004 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 393133005005 anticodon binding site; other site 393133005006 primosomal protein DnaI; Reviewed; Region: PRK08939 393133005007 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 393133005008 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 393133005009 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 393133005010 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 393133005011 ATP cone domain; Region: ATP-cone; pfam03477 393133005012 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 393133005013 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 393133005014 CoA-binding site [chemical binding]; other site 393133005015 ATP-binding [chemical binding]; other site 393133005016 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 393133005017 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 393133005018 DNA binding site [nucleotide binding] 393133005019 catalytic residue [active] 393133005020 H2TH interface [polypeptide binding]; other site 393133005021 putative catalytic residues [active] 393133005022 turnover-facilitating residue; other site 393133005023 intercalation triad [nucleotide binding]; other site 393133005024 8OG recognition residue [nucleotide binding]; other site 393133005025 putative reading head residues; other site 393133005026 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 393133005027 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393133005028 DNA polymerase I; Provisional; Region: PRK05755 393133005029 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 393133005030 active site 393133005031 metal binding site 1 [ion binding]; metal-binding site 393133005032 putative 5' ssDNA interaction site; other site 393133005033 metal binding site 3; metal-binding site 393133005034 metal binding site 2 [ion binding]; metal-binding site 393133005035 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 393133005036 putative DNA binding site [nucleotide binding]; other site 393133005037 putative metal binding site [ion binding]; other site 393133005038 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 393133005039 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 393133005040 active site 393133005041 DNA binding site [nucleotide binding] 393133005042 catalytic site [active] 393133005043 isocitrate dehydrogenase; Reviewed; Region: PRK07006 393133005044 isocitrate dehydrogenase; Validated; Region: PRK07362 393133005045 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 393133005046 dimer interface [polypeptide binding]; other site 393133005047 Citrate synthase; Region: Citrate_synt; pfam00285 393133005048 active site 393133005049 citrylCoA binding site [chemical binding]; other site 393133005050 oxalacetate/citrate binding site [chemical binding]; other site 393133005051 coenzyme A binding site [chemical binding]; other site 393133005052 catalytic triad [active] 393133005053 Protein of unknown function (DUF441); Region: DUF441; pfam04284 393133005054 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 393133005055 pyruvate kinase; Provisional; Region: PRK06354 393133005056 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 393133005057 domain interfaces; other site 393133005058 active site 393133005059 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 393133005060 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 393133005061 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 393133005062 active site 393133005063 ADP/pyrophosphate binding site [chemical binding]; other site 393133005064 dimerization interface [polypeptide binding]; other site 393133005065 allosteric effector site; other site 393133005066 fructose-1,6-bisphosphate binding site; other site 393133005067 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 393133005068 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 393133005069 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 393133005070 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 393133005071 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 393133005072 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 393133005073 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 393133005074 active site 393133005075 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 393133005076 generic binding surface I; other site 393133005077 generic binding surface II; other site 393133005078 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 393133005079 DHH family; Region: DHH; pfam01368 393133005080 DHHA1 domain; Region: DHHA1; pfam02272 393133005081 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 393133005082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 393133005083 DNA-binding site [nucleotide binding]; DNA binding site 393133005084 DRTGG domain; Region: DRTGG; pfam07085 393133005085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 393133005086 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 393133005087 active site 2 [active] 393133005088 active site 1 [active] 393133005089 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 393133005090 metal-dependent hydrolase; Provisional; Region: PRK00685 393133005091 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 393133005092 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 393133005093 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 393133005094 active site 393133005095 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 393133005096 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 393133005097 hexamer interface [polypeptide binding]; other site 393133005098 ligand binding site [chemical binding]; other site 393133005099 putative active site [active] 393133005100 NAD(P) binding site [chemical binding]; other site 393133005101 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393133005102 Ligand Binding Site [chemical binding]; other site 393133005103 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 393133005104 propionate/acetate kinase; Provisional; Region: PRK12379 393133005105 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 393133005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005107 S-adenosylmethionine binding site [chemical binding]; other site 393133005108 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 393133005109 dimer interface [polypeptide binding]; other site 393133005110 catalytic triad [active] 393133005111 peroxidatic and resolving cysteines [active] 393133005112 RDD family; Region: RDD; pfam06271 393133005113 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 393133005114 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 393133005115 tandem repeat interface [polypeptide binding]; other site 393133005116 oligomer interface [polypeptide binding]; other site 393133005117 active site residues [active] 393133005118 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 393133005119 ATP-NAD kinase; Region: NAD_kinase; pfam01513 393133005120 ornithine carbamoyltransferase; Provisional; Region: PRK00779 393133005121 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393133005122 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393133005123 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 393133005124 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393133005125 inhibitor-cofactor binding pocket; inhibition site 393133005126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005127 catalytic residue [active] 393133005128 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 393133005129 nucleotide binding site [chemical binding]; other site 393133005130 N-acetyl-L-glutamate binding site [chemical binding]; other site 393133005131 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 393133005132 heterotetramer interface [polypeptide binding]; other site 393133005133 active site pocket [active] 393133005134 cleavage site 393133005135 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 393133005136 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 393133005137 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 393133005138 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 393133005139 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 393133005140 Ligand Binding Site [chemical binding]; other site 393133005141 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393133005142 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393133005143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393133005144 catalytic residue [active] 393133005145 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 393133005146 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 393133005147 GAF domain; Region: GAF_2; pfam13185 393133005148 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 393133005149 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 393133005150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133005151 RNA binding surface [nucleotide binding]; other site 393133005152 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 393133005153 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 393133005154 active site 393133005155 HIGH motif; other site 393133005156 dimer interface [polypeptide binding]; other site 393133005157 KMSKS motif; other site 393133005158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133005159 RNA binding surface [nucleotide binding]; other site 393133005160 catabolite control protein A; Region: ccpA; TIGR01481 393133005161 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133005162 DNA binding site [nucleotide binding] 393133005163 domain linker motif; other site 393133005164 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 393133005165 dimerization interface [polypeptide binding]; other site 393133005166 effector binding site; other site 393133005167 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 393133005168 Chorismate mutase type II; Region: CM_2; cl00693 393133005169 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 393133005170 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 393133005171 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 393133005172 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 393133005173 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 393133005174 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 393133005175 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 393133005176 dimer interface [polypeptide binding]; other site 393133005177 decamer (pentamer of dimers) interface [polypeptide binding]; other site 393133005178 catalytic triad [active] 393133005179 peroxidatic and resolving cysteines [active] 393133005180 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 393133005181 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393133005182 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393133005183 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393133005184 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 393133005185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393133005186 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 393133005187 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 393133005188 putative tRNA-binding site [nucleotide binding]; other site 393133005189 hypothetical protein; Provisional; Region: PRK13668 393133005190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133005191 catalytic residues [active] 393133005192 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393133005193 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 393133005194 oligomer interface [polypeptide binding]; other site 393133005195 active site 393133005196 metal binding site [ion binding]; metal-binding site 393133005197 Predicted small secreted protein [Function unknown]; Region: COG5584 393133005198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 393133005199 putative homodimer interface [polypeptide binding]; other site 393133005200 putative homotetramer interface [polypeptide binding]; other site 393133005201 putative allosteric switch controlling residues; other site 393133005202 putative metal binding site [ion binding]; other site 393133005203 putative homodimer-homodimer interface [polypeptide binding]; other site 393133005204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133005205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005206 S-adenosylmethionine binding site [chemical binding]; other site 393133005207 Phosphotransferase enzyme family; Region: APH; pfam01636 393133005208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 393133005209 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 393133005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133005211 putative substrate translocation pore; other site 393133005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133005213 MarR family; Region: MarR; pfam01047 393133005214 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 393133005215 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393133005216 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 393133005217 homodimer interface [polypeptide binding]; other site 393133005218 substrate-cofactor binding pocket; other site 393133005219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005220 catalytic residue [active] 393133005221 dipeptidase PepV; Reviewed; Region: PRK07318 393133005222 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 393133005223 active site 393133005224 metal binding site [ion binding]; metal-binding site 393133005225 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 393133005226 nudix motif; other site 393133005227 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 393133005228 putative substrate binding site [chemical binding]; other site 393133005229 putative ATP binding site [chemical binding]; other site 393133005230 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 393133005231 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 393133005232 active site 393133005233 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393133005234 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393133005235 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393133005236 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393133005237 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 393133005238 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 393133005239 substrate binding site [chemical binding]; other site 393133005240 active site 393133005241 catalytic residues [active] 393133005242 heterodimer interface [polypeptide binding]; other site 393133005243 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 393133005244 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 393133005245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005246 catalytic residue [active] 393133005247 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 393133005248 active site 393133005249 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 393133005250 active site 393133005251 ribulose/triose binding site [chemical binding]; other site 393133005252 phosphate binding site [ion binding]; other site 393133005253 substrate (anthranilate) binding pocket [chemical binding]; other site 393133005254 product (indole) binding pocket [chemical binding]; other site 393133005255 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 393133005256 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 393133005257 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 393133005258 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393133005259 Glutamine amidotransferase class-I; Region: GATase; pfam00117 393133005260 glutamine binding [chemical binding]; other site 393133005261 catalytic triad [active] 393133005262 anthranilate synthase component I; Provisional; Region: PRK13570 393133005263 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 393133005264 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 393133005265 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 393133005266 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 393133005267 putative catalytic cysteine [active] 393133005268 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 393133005269 putative active site [active] 393133005270 metal binding site [ion binding]; metal-binding site 393133005271 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393133005272 dimer interface [polypeptide binding]; other site 393133005273 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133005274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133005275 Walker A/P-loop; other site 393133005276 ATP binding site [chemical binding]; other site 393133005277 Q-loop/lid; other site 393133005278 ABC transporter signature motif; other site 393133005279 Walker B; other site 393133005280 D-loop; other site 393133005281 H-loop/switch region; other site 393133005282 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393133005283 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 393133005284 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 393133005285 putative dimer interface [polypeptide binding]; other site 393133005286 catalytic triad [active] 393133005287 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 393133005288 aconitate hydratase; Validated; Region: PRK09277 393133005289 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 393133005290 substrate binding site [chemical binding]; other site 393133005291 ligand binding site [chemical binding]; other site 393133005292 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 393133005293 substrate binding site [chemical binding]; other site 393133005294 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133005295 Heat induced stress protein YflT; Region: YflT; pfam11181 393133005296 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 393133005297 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 393133005298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133005299 ATP binding site [chemical binding]; other site 393133005300 putative Mg++ binding site [ion binding]; other site 393133005301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133005302 nucleotide binding region [chemical binding]; other site 393133005303 ATP-binding site [chemical binding]; other site 393133005304 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 393133005305 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 393133005306 Walker A/P-loop; other site 393133005307 ATP binding site [chemical binding]; other site 393133005308 Q-loop/lid; other site 393133005309 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 393133005310 ABC transporter signature motif; other site 393133005311 Walker B; other site 393133005312 D-loop; other site 393133005313 H-loop/switch region; other site 393133005314 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 393133005315 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 393133005316 active site 393133005317 metal binding site [ion binding]; metal-binding site 393133005318 DNA binding site [nucleotide binding] 393133005319 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 393133005320 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 393133005321 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 393133005322 putative acyl-acceptor binding pocket; other site 393133005323 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 393133005324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133005325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133005326 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 393133005327 Walker A/P-loop; other site 393133005328 ATP binding site [chemical binding]; other site 393133005329 Q-loop/lid; other site 393133005330 ABC transporter signature motif; other site 393133005331 Walker B; other site 393133005332 D-loop; other site 393133005333 H-loop/switch region; other site 393133005334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133005335 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 393133005336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133005337 Walker A/P-loop; other site 393133005338 ATP binding site [chemical binding]; other site 393133005339 Q-loop/lid; other site 393133005340 ABC transporter signature motif; other site 393133005341 Walker B; other site 393133005342 D-loop; other site 393133005343 H-loop/switch region; other site 393133005344 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 393133005345 active site 393133005346 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393133005347 elongation factor Ts; Provisional; Region: tsf; PRK09377 393133005348 UBA/TS-N domain; Region: UBA; pfam00627 393133005349 Elongation factor TS; Region: EF_TS; pfam00889 393133005350 Elongation factor TS; Region: EF_TS; pfam00889 393133005351 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 393133005352 rRNA interaction site [nucleotide binding]; other site 393133005353 S8 interaction site; other site 393133005354 putative laminin-1 binding site; other site 393133005355 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 393133005356 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393133005357 HIGH motif; other site 393133005358 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393133005359 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393133005360 active site 393133005361 KMSKS motif; other site 393133005362 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 393133005363 tRNA binding surface [nucleotide binding]; other site 393133005364 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 393133005365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393133005366 FeS/SAM binding site; other site 393133005367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005368 S-adenosylmethionine binding site [chemical binding]; other site 393133005369 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 393133005370 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 393133005371 active site 393133005372 dimer interface [polypeptide binding]; other site 393133005373 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 393133005374 Ligand Binding Site [chemical binding]; other site 393133005375 Molecular Tunnel; other site 393133005376 S-adenosylmethionine synthetase; Validated; Region: PRK05250 393133005377 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 393133005378 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 393133005379 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 393133005380 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393133005381 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393133005382 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393133005383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133005384 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 393133005385 NAD binding site [chemical binding]; other site 393133005386 dimer interface [polypeptide binding]; other site 393133005387 substrate binding site [chemical binding]; other site 393133005388 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 393133005389 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 393133005390 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 393133005391 nudix motif; other site 393133005392 Uncharacterized conserved protein [Function unknown]; Region: COG0759 393133005393 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393133005394 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 393133005395 metal binding site [ion binding]; metal-binding site 393133005396 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 393133005397 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 393133005398 acyl-activating enzyme (AAE) consensus motif; other site 393133005399 putative AMP binding site [chemical binding]; other site 393133005400 putative active site [active] 393133005401 putative CoA binding site [chemical binding]; other site 393133005402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 393133005403 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 393133005404 substrate binding site [chemical binding]; other site 393133005405 oxyanion hole (OAH) forming residues; other site 393133005406 trimer interface [polypeptide binding]; other site 393133005407 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133005408 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 393133005409 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 393133005410 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 393133005411 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 393133005412 dimer interface [polypeptide binding]; other site 393133005413 tetramer interface [polypeptide binding]; other site 393133005414 PYR/PP interface [polypeptide binding]; other site 393133005415 TPP binding site [chemical binding]; other site 393133005416 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 393133005417 TPP-binding site; other site 393133005418 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 393133005419 chorismate binding enzyme; Region: Chorismate_bind; cl10555 393133005420 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 393133005421 UbiA prenyltransferase family; Region: UbiA; pfam01040 393133005422 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 393133005423 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 393133005424 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 393133005425 FAD binding site [chemical binding]; other site 393133005426 cystathionine beta-lyase; Provisional; Region: PRK08064 393133005427 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393133005428 homodimer interface [polypeptide binding]; other site 393133005429 substrate-cofactor binding pocket; other site 393133005430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005431 catalytic residue [active] 393133005432 cystathionine gamma-synthase; Reviewed; Region: PRK08247 393133005433 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393133005434 homodimer interface [polypeptide binding]; other site 393133005435 substrate-cofactor binding pocket; other site 393133005436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005437 catalytic residue [active] 393133005438 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 393133005439 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 393133005440 THF binding site; other site 393133005441 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 393133005442 substrate binding site [chemical binding]; other site 393133005443 THF binding site; other site 393133005444 zinc-binding site [ion binding]; other site 393133005445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133005446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133005447 putative substrate translocation pore; other site 393133005448 ferric uptake regulator; Provisional; Region: fur; PRK09462 393133005449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393133005450 metal binding site 2 [ion binding]; metal-binding site 393133005451 putative DNA binding helix; other site 393133005452 metal binding site 1 [ion binding]; metal-binding site 393133005453 dimer interface [polypeptide binding]; other site 393133005454 structural Zn2+ binding site [ion binding]; other site 393133005455 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 393133005456 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 393133005457 NAD binding site [chemical binding]; other site 393133005458 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 393133005459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393133005460 inhibitor-cofactor binding pocket; inhibition site 393133005461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133005462 catalytic residue [active] 393133005463 Predicted membrane protein [Function unknown]; Region: COG4129 393133005464 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 393133005465 hypothetical protein; Provisional; Region: PRK13662 393133005466 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 393133005467 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 393133005468 putative NAD(P) binding site [chemical binding]; other site 393133005469 active site 393133005470 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 393133005471 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393133005472 minor groove reading motif; other site 393133005473 helix-hairpin-helix signature motif; other site 393133005474 substrate binding pocket [chemical binding]; other site 393133005475 active site 393133005476 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 393133005477 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 393133005478 DNA binding and oxoG recognition site [nucleotide binding] 393133005479 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 393133005480 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 393133005481 trimer interface [polypeptide binding]; other site 393133005482 active site 393133005483 WVELL protein; Region: WVELL; pfam14043 393133005484 recombination regulator RecX; Provisional; Region: recX; PRK14135 393133005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393133005486 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 393133005487 NAD(P) binding site [chemical binding]; other site 393133005488 active site 393133005489 Predicted integral membrane protein [Function unknown]; Region: COG0392 393133005490 Uncharacterized conserved protein [Function unknown]; Region: COG2898 393133005491 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 393133005492 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393133005493 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393133005494 Cation efflux family; Region: Cation_efflux; pfam01545 393133005495 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393133005496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393133005497 PAS fold; Region: PAS_4; pfam08448 393133005498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393133005499 putative active site [active] 393133005500 heme pocket [chemical binding]; other site 393133005501 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 393133005502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 393133005503 dimer interface [polypeptide binding]; other site 393133005504 putative CheW interface [polypeptide binding]; other site 393133005505 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 393133005506 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 393133005507 dimer interface [polypeptide binding]; other site 393133005508 active site 393133005509 Mn binding site [ion binding]; other site 393133005510 TRAM domain; Region: TRAM; cl01282 393133005511 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 393133005512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005513 S-adenosylmethionine binding site [chemical binding]; other site 393133005514 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 393133005515 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 393133005516 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 393133005517 Substrate-binding site [chemical binding]; other site 393133005518 Substrate specificity [chemical binding]; other site 393133005519 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 393133005520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 393133005521 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 393133005522 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 393133005523 active site 393133005524 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 393133005525 flavodoxin, short chain; Region: flav_short; TIGR01753 393133005526 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 393133005527 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 393133005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133005529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133005530 putative substrate translocation pore; other site 393133005531 rod-share determining protein MreBH; Provisional; Region: PRK13929 393133005532 MreB and similar proteins; Region: MreB_like; cd10225 393133005533 nucleotide binding site [chemical binding]; other site 393133005534 Mg binding site [ion binding]; other site 393133005535 putative protofilament interaction site [polypeptide binding]; other site 393133005536 RodZ interaction site [polypeptide binding]; other site 393133005537 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393133005538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005539 S-adenosylmethionine binding site [chemical binding]; other site 393133005540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133005541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133005542 Uncharacterized conserved protein [Function unknown]; Region: COG3589 393133005543 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 393133005544 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133005545 methionine cluster; other site 393133005546 active site 393133005547 phosphorylation site [posttranslational modification] 393133005548 metal binding site [ion binding]; metal-binding site 393133005549 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133005550 active site 393133005551 P-loop; other site 393133005552 phosphorylation site [posttranslational modification] 393133005553 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 393133005554 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 393133005555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133005556 Walker A motif; other site 393133005557 ATP binding site [chemical binding]; other site 393133005558 Walker B motif; other site 393133005559 arginine finger; other site 393133005560 Transcriptional antiterminator [Transcription]; Region: COG3933 393133005561 PRD domain; Region: PRD; pfam00874 393133005562 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133005563 active pocket/dimerization site; other site 393133005564 active site 393133005565 phosphorylation site [posttranslational modification] 393133005566 PRD domain; Region: PRD; pfam00874 393133005567 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 393133005568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393133005569 ATP binding site [chemical binding]; other site 393133005570 putative Mg++ binding site [ion binding]; other site 393133005571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133005572 nucleotide binding region [chemical binding]; other site 393133005573 ATP-binding site [chemical binding]; other site 393133005574 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393133005575 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133005576 Walker A/P-loop; other site 393133005577 ATP binding site [chemical binding]; other site 393133005578 Q-loop/lid; other site 393133005579 ABC transporter signature motif; other site 393133005580 Walker B; other site 393133005581 D-loop; other site 393133005582 H-loop/switch region; other site 393133005583 Predicted transcriptional regulators [Transcription]; Region: COG1725 393133005584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133005585 DNA-binding site [nucleotide binding]; DNA binding site 393133005586 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133005587 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133005588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133005589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133005590 DNA binding site [nucleotide binding] 393133005591 domain linker motif; other site 393133005592 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133005593 dimerization interface [polypeptide binding]; other site 393133005594 ligand binding site [chemical binding]; other site 393133005595 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 393133005596 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 393133005597 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 393133005598 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 393133005599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393133005600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133005601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133005602 dimer interface [polypeptide binding]; other site 393133005603 conserved gate region; other site 393133005604 putative PBP binding loops; other site 393133005605 ABC-ATPase subunit interface; other site 393133005606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133005607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133005608 dimer interface [polypeptide binding]; other site 393133005609 conserved gate region; other site 393133005610 putative PBP binding loops; other site 393133005611 ABC-ATPase subunit interface; other site 393133005612 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 393133005613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393133005614 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 393133005615 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 393133005616 active site 393133005617 dimer interface [polypeptide binding]; other site 393133005618 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 393133005619 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 393133005620 active site 393133005621 FMN binding site [chemical binding]; other site 393133005622 substrate binding site [chemical binding]; other site 393133005623 3Fe-4S cluster binding site [ion binding]; other site 393133005624 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 393133005625 domain interface; other site 393133005626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133005627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133005628 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393133005629 putative dimerization interface [polypeptide binding]; other site 393133005630 Predicted acetyltransferase [General function prediction only]; Region: COG3153 393133005631 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 393133005632 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 393133005633 putative active site [active] 393133005634 metal binding site [ion binding]; metal-binding site 393133005635 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393133005636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393133005637 substrate binding pocket [chemical binding]; other site 393133005638 membrane-bound complex binding site; other site 393133005639 hinge residues; other site 393133005640 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133005641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133005642 Walker A/P-loop; other site 393133005643 ATP binding site [chemical binding]; other site 393133005644 Q-loop/lid; other site 393133005645 ABC transporter signature motif; other site 393133005646 Walker B; other site 393133005647 D-loop; other site 393133005648 H-loop/switch region; other site 393133005649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133005650 dimer interface [polypeptide binding]; other site 393133005651 conserved gate region; other site 393133005652 putative PBP binding loops; other site 393133005653 ABC-ATPase subunit interface; other site 393133005654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393133005655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 393133005656 dimer interface [polypeptide binding]; other site 393133005657 phosphorylation site [posttranslational modification] 393133005658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133005659 ATP binding site [chemical binding]; other site 393133005660 Mg2+ binding site [ion binding]; other site 393133005661 G-X-G motif; other site 393133005662 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 393133005663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393133005664 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 393133005665 active site 393133005666 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 393133005667 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 393133005668 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 393133005669 putative NAD(P) binding site [chemical binding]; other site 393133005670 active site 393133005671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133005672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133005673 active site 393133005674 phosphorylation site [posttranslational modification] 393133005675 intermolecular recognition site; other site 393133005676 dimerization interface [polypeptide binding]; other site 393133005677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133005678 DNA binding site [nucleotide binding] 393133005679 FtsX-like permease family; Region: FtsX; pfam02687 393133005680 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393133005681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133005682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133005683 Walker A/P-loop; other site 393133005684 ATP binding site [chemical binding]; other site 393133005685 Q-loop/lid; other site 393133005686 ABC transporter signature motif; other site 393133005687 Walker B; other site 393133005688 D-loop; other site 393133005689 H-loop/switch region; other site 393133005690 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 393133005691 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 393133005692 ADP binding site [chemical binding]; other site 393133005693 magnesium binding site [ion binding]; other site 393133005694 putative shikimate binding site; other site 393133005695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 393133005696 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 393133005697 TRAM domain; Region: TRAM; pfam01938 393133005698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005699 S-adenosylmethionine binding site [chemical binding]; other site 393133005700 putative lipid kinase; Reviewed; Region: PRK13337 393133005701 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393133005702 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 393133005703 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 393133005704 GatB domain; Region: GatB_Yqey; pfam02637 393133005705 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 393133005706 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 393133005707 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 393133005708 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 393133005709 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 393133005710 putative dimer interface [polypeptide binding]; other site 393133005711 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 393133005712 putative dimer interface [polypeptide binding]; other site 393133005713 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 393133005714 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 393133005715 nucleotide binding pocket [chemical binding]; other site 393133005716 K-X-D-G motif; other site 393133005717 catalytic site [active] 393133005718 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 393133005719 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 393133005720 Dimer interface [polypeptide binding]; other site 393133005721 BRCT sequence motif; other site 393133005722 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 393133005723 Part of AAA domain; Region: AAA_19; pfam13245 393133005724 Family description; Region: UvrD_C_2; pfam13538 393133005725 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 393133005726 PcrB family; Region: PcrB; pfam01884 393133005727 substrate binding site [chemical binding]; other site 393133005728 putative active site [active] 393133005729 dimer interface [polypeptide binding]; other site 393133005730 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 393133005731 Na2 binding site [ion binding]; other site 393133005732 putative substrate binding site 1 [chemical binding]; other site 393133005733 Na binding site 1 [ion binding]; other site 393133005734 putative substrate binding site 2 [chemical binding]; other site 393133005735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 393133005736 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 393133005737 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 393133005738 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 393133005739 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 393133005740 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 393133005741 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 393133005742 purine monophosphate binding site [chemical binding]; other site 393133005743 dimer interface [polypeptide binding]; other site 393133005744 putative catalytic residues [active] 393133005745 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 393133005746 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 393133005747 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 393133005748 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 393133005749 active site 393133005750 substrate binding site [chemical binding]; other site 393133005751 cosubstrate binding site; other site 393133005752 catalytic site [active] 393133005753 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 393133005754 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 393133005755 dimerization interface [polypeptide binding]; other site 393133005756 putative ATP binding site [chemical binding]; other site 393133005757 amidophosphoribosyltransferase; Provisional; Region: PRK06781 393133005758 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 393133005759 active site 393133005760 tetramer interface [polypeptide binding]; other site 393133005761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133005762 active site 393133005763 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 393133005764 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 393133005765 dimerization interface [polypeptide binding]; other site 393133005766 ATP binding site [chemical binding]; other site 393133005767 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 393133005768 dimerization interface [polypeptide binding]; other site 393133005769 ATP binding site [chemical binding]; other site 393133005770 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 393133005771 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 393133005772 putative active site [active] 393133005773 catalytic triad [active] 393133005774 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 393133005775 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 393133005776 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 393133005777 ATP binding site [chemical binding]; other site 393133005778 active site 393133005779 substrate binding site [chemical binding]; other site 393133005780 adenylosuccinate lyase; Provisional; Region: PRK07492 393133005781 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 393133005782 tetramer interface [polypeptide binding]; other site 393133005783 active site 393133005784 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 393133005785 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 393133005786 NAD binding site [chemical binding]; other site 393133005787 ATP-grasp domain; Region: ATP-grasp; pfam02222 393133005788 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 393133005789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 393133005790 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133005791 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 393133005792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133005793 Zn2+ binding site [ion binding]; other site 393133005794 Mg2+ binding site [ion binding]; other site 393133005795 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393133005796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133005797 Walker A/P-loop; other site 393133005798 ATP binding site [chemical binding]; other site 393133005799 Q-loop/lid; other site 393133005800 ABC transporter signature motif; other site 393133005801 Walker B; other site 393133005802 D-loop; other site 393133005803 H-loop/switch region; other site 393133005804 peptidase T; Region: peptidase-T; TIGR01882 393133005805 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 393133005806 metal binding site [ion binding]; metal-binding site 393133005807 dimer interface [polypeptide binding]; other site 393133005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 393133005809 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 393133005810 active site 393133005811 putative catalytic site [active] 393133005812 DNA binding site [nucleotide binding] 393133005813 putative phosphate binding site [ion binding]; other site 393133005814 metal binding site A [ion binding]; metal-binding site 393133005815 AP binding site [nucleotide binding]; other site 393133005816 metal binding site B [ion binding]; metal-binding site 393133005817 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 393133005818 23S rRNA binding site [nucleotide binding]; other site 393133005819 L21 binding site [polypeptide binding]; other site 393133005820 L13 binding site [polypeptide binding]; other site 393133005821 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 393133005822 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 393133005823 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 393133005824 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 393133005825 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133005826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133005827 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133005828 Substrate binding site [chemical binding]; other site 393133005829 Leucine rich repeat; Region: LRR_8; pfam13855 393133005830 LRR adjacent; Region: LRR_adjacent; pfam08191 393133005831 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 393133005832 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 393133005833 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393133005834 DNA binding residues [nucleotide binding] 393133005835 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393133005836 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393133005837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133005838 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 393133005839 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 393133005840 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 393133005841 RimM N-terminal domain; Region: RimM; pfam01782 393133005842 PRC-barrel domain; Region: PRC; pfam05239 393133005843 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 393133005844 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 393133005845 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 393133005846 catalytic triad [active] 393133005847 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 393133005848 KH domain; Region: KH_4; pfam13083 393133005849 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 393133005850 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 393133005851 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 393133005852 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 393133005853 signal recognition particle protein; Provisional; Region: PRK10867 393133005854 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 393133005855 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393133005856 P loop; other site 393133005857 GTP binding site [chemical binding]; other site 393133005858 Signal peptide binding domain; Region: SRP_SPB; pfam02978 393133005859 putative DNA-binding protein; Validated; Region: PRK00118 393133005860 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 393133005861 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 393133005862 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 393133005863 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393133005864 P loop; other site 393133005865 GTP binding site [chemical binding]; other site 393133005866 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 393133005867 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 393133005868 Walker A/P-loop; other site 393133005869 ATP binding site [chemical binding]; other site 393133005870 Q-loop/lid; other site 393133005871 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 393133005872 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 393133005873 ABC transporter signature motif; other site 393133005874 Walker B; other site 393133005875 D-loop; other site 393133005876 H-loop/switch region; other site 393133005877 ribonuclease III; Reviewed; Region: rnc; PRK00102 393133005878 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 393133005879 dimerization interface [polypeptide binding]; other site 393133005880 active site 393133005881 metal binding site [ion binding]; metal-binding site 393133005882 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 393133005883 dsRNA binding site [nucleotide binding]; other site 393133005884 acyl carrier protein; Provisional; Region: acpP; PRK00982 393133005885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 393133005886 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 393133005887 NAD(P) binding site [chemical binding]; other site 393133005888 homotetramer interface [polypeptide binding]; other site 393133005889 homodimer interface [polypeptide binding]; other site 393133005890 active site 393133005891 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 393133005892 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 393133005893 putative phosphate acyltransferase; Provisional; Region: PRK05331 393133005894 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 393133005895 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 393133005896 active site 2 [active] 393133005897 active site 1 [active] 393133005898 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 393133005899 Y-family of DNA polymerases; Region: PolY; cl12025 393133005900 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 393133005901 generic binding surface II; other site 393133005902 ssDNA binding site; other site 393133005903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133005904 ATP binding site [chemical binding]; other site 393133005905 putative Mg++ binding site [ion binding]; other site 393133005906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133005907 nucleotide binding region [chemical binding]; other site 393133005908 ATP-binding site [chemical binding]; other site 393133005909 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 393133005910 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 393133005911 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 393133005912 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 393133005913 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 393133005914 putative L-serine binding site [chemical binding]; other site 393133005915 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 393133005916 DAK2 domain; Region: Dak2; pfam02734 393133005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 393133005918 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 393133005919 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 393133005920 Thiamine pyrophosphokinase; Region: TPK; cd07995 393133005921 active site 393133005922 dimerization interface [polypeptide binding]; other site 393133005923 thiamine binding site [chemical binding]; other site 393133005924 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133005925 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133005926 substrate binding site [chemical binding]; other site 393133005927 hexamer interface [polypeptide binding]; other site 393133005928 metal binding site [ion binding]; metal-binding site 393133005929 GTPase RsgA; Reviewed; Region: PRK00098 393133005930 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 393133005931 RNA binding site [nucleotide binding]; other site 393133005932 homodimer interface [polypeptide binding]; other site 393133005933 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 393133005934 GTPase/Zn-binding domain interface [polypeptide binding]; other site 393133005935 GTP/Mg2+ binding site [chemical binding]; other site 393133005936 G4 box; other site 393133005937 G1 box; other site 393133005938 Switch I region; other site 393133005939 G2 box; other site 393133005940 G3 box; other site 393133005941 Switch II region; other site 393133005942 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 393133005943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 393133005944 active site 393133005945 ATP binding site [chemical binding]; other site 393133005946 substrate binding site [chemical binding]; other site 393133005947 activation loop (A-loop); other site 393133005948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 393133005949 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393133005950 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393133005951 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393133005952 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 393133005953 Protein phosphatase 2C; Region: PP2C; pfam00481 393133005954 active site 393133005955 16S rRNA methyltransferase B; Provisional; Region: PRK14902 393133005956 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 393133005957 putative RNA binding site [nucleotide binding]; other site 393133005958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133005959 S-adenosylmethionine binding site [chemical binding]; other site 393133005960 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 393133005961 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 393133005962 putative active site [active] 393133005963 substrate binding site [chemical binding]; other site 393133005964 putative cosubstrate binding site; other site 393133005965 catalytic site [active] 393133005966 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 393133005967 substrate binding site [chemical binding]; other site 393133005968 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 393133005969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133005970 ATP binding site [chemical binding]; other site 393133005971 putative Mg++ binding site [ion binding]; other site 393133005972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133005973 ATP-binding site [chemical binding]; other site 393133005974 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 393133005975 Flavoprotein; Region: Flavoprotein; pfam02441 393133005976 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 393133005977 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 393133005978 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 393133005979 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 393133005980 catalytic site [active] 393133005981 G-X2-G-X-G-K; other site 393133005982 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 393133005983 Domain of unknown function (DUF814); Region: DUF814; pfam05670 393133005984 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 393133005985 putative NAD(P) binding site [chemical binding]; other site 393133005986 homodimer interface [polypeptide binding]; other site 393133005987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133005988 active site 393133005989 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 393133005990 active site 393133005991 dimer interface [polypeptide binding]; other site 393133005992 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 393133005993 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 393133005994 heterodimer interface [polypeptide binding]; other site 393133005995 active site 393133005996 FMN binding site [chemical binding]; other site 393133005997 homodimer interface [polypeptide binding]; other site 393133005998 substrate binding site [chemical binding]; other site 393133005999 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 393133006000 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 393133006001 FAD binding pocket [chemical binding]; other site 393133006002 FAD binding motif [chemical binding]; other site 393133006003 phosphate binding motif [ion binding]; other site 393133006004 beta-alpha-beta structure motif; other site 393133006005 NAD binding pocket [chemical binding]; other site 393133006006 Iron coordination center [ion binding]; other site 393133006007 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 393133006008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393133006009 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393133006010 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 393133006011 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393133006012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393133006013 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 393133006014 IMP binding site; other site 393133006015 dimer interface [polypeptide binding]; other site 393133006016 interdomain contacts; other site 393133006017 partial ornithine binding site; other site 393133006018 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 393133006019 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 393133006020 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 393133006021 catalytic site [active] 393133006022 subunit interface [polypeptide binding]; other site 393133006023 dihydroorotase; Validated; Region: pyrC; PRK09357 393133006024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393133006025 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 393133006026 active site 393133006027 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 393133006028 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393133006029 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393133006030 uracil transporter; Provisional; Region: PRK10720 393133006031 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 393133006032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133006033 active site 393133006034 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393133006035 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393133006036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133006037 RNA binding surface [nucleotide binding]; other site 393133006038 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393133006039 active site 393133006040 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 393133006041 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393133006042 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393133006043 multidrug efflux protein; Reviewed; Region: PRK01766 393133006044 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 393133006045 cation binding site [ion binding]; other site 393133006046 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393133006047 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 393133006048 metal binding site [ion binding]; metal-binding site 393133006049 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393133006050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133006051 ABC-ATPase subunit interface; other site 393133006052 dimer interface [polypeptide binding]; other site 393133006053 putative PBP binding regions; other site 393133006054 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 393133006055 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393133006056 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133006057 MarR family; Region: MarR; pfam01047 393133006058 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 393133006059 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 393133006060 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 393133006061 protein binding site [polypeptide binding]; other site 393133006062 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 393133006063 Catalytic dyad [active] 393133006064 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 393133006065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 393133006066 metal-binding site [ion binding] 393133006067 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 393133006068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 393133006069 metal-binding site [ion binding] 393133006070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133006071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133006072 motif II; other site 393133006073 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 393133006074 putative homodimer interface [polypeptide binding]; other site 393133006075 putative homotetramer interface [polypeptide binding]; other site 393133006076 putative allosteric switch controlling residues; other site 393133006077 putative metal binding site [ion binding]; other site 393133006078 putative homodimer-homodimer interface [polypeptide binding]; other site 393133006079 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 393133006080 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 393133006081 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 393133006082 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 393133006083 hypothetical protein; Provisional; Region: PRK13672 393133006084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133006085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133006086 methionine sulfoxide reductase B; Provisional; Region: PRK00222 393133006087 SelR domain; Region: SelR; pfam01641 393133006088 methionine sulfoxide reductase A; Provisional; Region: PRK14054 393133006089 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 393133006090 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 393133006091 active site 393133006092 catalytic triad [active] 393133006093 oxyanion hole [active] 393133006094 EDD domain protein, DegV family; Region: DegV; TIGR00762 393133006095 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393133006096 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 393133006097 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 393133006098 HTH domain; Region: HTH_11; pfam08279 393133006099 FOG: CBS domain [General function prediction only]; Region: COG0517 393133006100 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 393133006101 PEP synthetase regulatory protein; Provisional; Region: PRK05339 393133006102 pyruvate phosphate dikinase; Provisional; Region: PRK09279 393133006103 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393133006104 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393133006105 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 393133006106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133006107 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 393133006108 Predicted membrane protein [Function unknown]; Region: COG4129 393133006109 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 393133006110 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 393133006111 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393133006112 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393133006113 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 393133006114 active site 393133006115 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 393133006116 substrate binding site [chemical binding]; other site 393133006117 metal binding site [ion binding]; metal-binding site 393133006118 Methyltransferase domain; Region: Methyltransf_23; pfam13489 393133006119 Methyltransferase domain; Region: Methyltransf_18; pfam12847 393133006120 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 393133006121 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 393133006122 folate binding site [chemical binding]; other site 393133006123 NADP+ binding site [chemical binding]; other site 393133006124 thymidylate synthase; Region: thym_sym; TIGR03284 393133006125 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 393133006126 dimerization interface [polypeptide binding]; other site 393133006127 active site 393133006128 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393133006129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133006130 Walker A/P-loop; other site 393133006131 ATP binding site [chemical binding]; other site 393133006132 Q-loop/lid; other site 393133006133 ABC transporter signature motif; other site 393133006134 Walker B; other site 393133006135 D-loop; other site 393133006136 H-loop/switch region; other site 393133006137 ABC transporter; Region: ABC_tran_2; pfam12848 393133006138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133006139 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 393133006140 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 393133006141 Potassium binding sites [ion binding]; other site 393133006142 Cesium cation binding sites [ion binding]; other site 393133006143 manganese transport transcriptional regulator; Provisional; Region: PRK03902 393133006144 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 393133006145 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 393133006146 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393133006147 DNA-binding site [nucleotide binding]; DNA binding site 393133006148 RNA-binding motif; other site 393133006149 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 393133006150 RNA/DNA hybrid binding site [nucleotide binding]; other site 393133006151 active site 393133006152 5'-3' exonuclease; Region: 53EXOc; smart00475 393133006153 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 393133006154 active site 393133006155 metal binding site 1 [ion binding]; metal-binding site 393133006156 putative 5' ssDNA interaction site; other site 393133006157 metal binding site 3; metal-binding site 393133006158 metal binding site 2 [ion binding]; metal-binding site 393133006159 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 393133006160 putative DNA binding site [nucleotide binding]; other site 393133006161 putative metal binding site [ion binding]; other site 393133006162 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 393133006163 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 393133006164 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 393133006165 putative active site [active] 393133006166 xanthine permease; Region: pbuX; TIGR03173 393133006167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133006168 active site 393133006169 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 393133006170 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 393133006171 active site 393133006172 Zn binding site [ion binding]; other site 393133006173 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 393133006174 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 393133006175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393133006176 cell division protein GpsB; Provisional; Region: PRK14127 393133006177 DivIVA domain; Region: DivI1A_domain; TIGR03544 393133006178 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 393133006179 hypothetical protein; Provisional; Region: PRK13660 393133006180 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 393133006181 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 393133006182 Transglycosylase; Region: Transgly; pfam00912 393133006183 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 393133006184 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393133006185 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 393133006186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393133006187 minor groove reading motif; other site 393133006188 helix-hairpin-helix signature motif; other site 393133006189 substrate binding pocket [chemical binding]; other site 393133006190 active site 393133006191 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 393133006192 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 393133006193 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 393133006194 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 393133006195 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 393133006196 putative dimer interface [polypeptide binding]; other site 393133006197 putative anticodon binding site; other site 393133006198 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 393133006199 homodimer interface [polypeptide binding]; other site 393133006200 motif 1; other site 393133006201 motif 2; other site 393133006202 active site 393133006203 motif 3; other site 393133006204 aspartate aminotransferase; Provisional; Region: PRK05764 393133006205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133006206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133006207 homodimer interface [polypeptide binding]; other site 393133006208 catalytic residue [active] 393133006209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 393133006210 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393133006211 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 393133006212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 393133006213 active site 393133006214 catalytic site [active] 393133006215 substrate binding site [chemical binding]; other site 393133006216 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 393133006217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393133006218 putative Mg++ binding site [ion binding]; other site 393133006219 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 393133006220 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 393133006221 tetramerization interface [polypeptide binding]; other site 393133006222 active site 393133006223 pantoate--beta-alanine ligase; Region: panC; TIGR00018 393133006224 Pantoate-beta-alanine ligase; Region: PanC; cd00560 393133006225 active site 393133006226 ATP-binding site [chemical binding]; other site 393133006227 pantoate-binding site; other site 393133006228 HXXH motif; other site 393133006229 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 393133006230 active site 393133006231 oligomerization interface [polypeptide binding]; other site 393133006232 metal binding site [ion binding]; metal-binding site 393133006233 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133006234 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393133006235 catalytic residues [active] 393133006236 Biotin operon repressor [Transcription]; Region: BirA; COG1654 393133006237 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 393133006238 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 393133006239 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 393133006240 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 393133006241 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 393133006242 active site 393133006243 NTP binding site [chemical binding]; other site 393133006244 metal binding triad [ion binding]; metal-binding site 393133006245 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 393133006246 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 393133006247 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 393133006248 active site 393133006249 dimer interfaces [polypeptide binding]; other site 393133006250 catalytic residues [active] 393133006251 dihydrodipicolinate reductase; Provisional; Region: PRK00048 393133006252 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 393133006253 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 393133006254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 393133006255 homodimer interface [polypeptide binding]; other site 393133006256 metal binding site [ion binding]; metal-binding site 393133006257 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393133006258 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133006259 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133006260 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133006261 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 393133006262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393133006263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393133006264 metal binding site [ion binding]; metal-binding site 393133006265 active site 393133006266 I-site; other site 393133006267 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 393133006268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393133006269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393133006270 metal binding site [ion binding]; metal-binding site 393133006271 active site 393133006272 I-site; other site 393133006273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393133006274 malate dehydrogenase; Provisional; Region: PRK13529 393133006275 Malic enzyme, N-terminal domain; Region: malic; pfam00390 393133006276 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 393133006277 NAD(P) binding pocket [chemical binding]; other site 393133006278 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 393133006279 Beta-lactamase; Region: Beta-lactamase; pfam00144 393133006280 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 393133006281 Pyruvate formate lyase 1; Region: PFL1; cd01678 393133006282 coenzyme A binding site [chemical binding]; other site 393133006283 active site 393133006284 catalytic residues [active] 393133006285 glycine loop; other site 393133006286 HI0933-like protein; Region: HI0933_like; pfam03486 393133006287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133006288 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 393133006289 Predicted membrane protein [Function unknown]; Region: COG4347 393133006290 hypothetical protein; Provisional; Region: PRK03636 393133006291 UPF0302 domain; Region: UPF0302; pfam08864 393133006292 IDEAL domain; Region: IDEAL; pfam08858 393133006293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 393133006294 binding surface 393133006295 TPR motif; other site 393133006296 TPR repeat; Region: TPR_11; pfam13414 393133006297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133006298 binding surface 393133006299 TPR motif; other site 393133006300 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 393133006301 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 393133006302 hinge; other site 393133006303 active site 393133006304 prephenate dehydrogenase; Validated; Region: PRK06545 393133006305 prephenate dehydrogenase; Validated; Region: PRK08507 393133006306 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 393133006307 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 393133006308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133006310 homodimer interface [polypeptide binding]; other site 393133006311 catalytic residue [active] 393133006312 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 393133006313 homotrimer interaction site [polypeptide binding]; other site 393133006314 active site 393133006315 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 393133006316 active site 393133006317 dimer interface [polypeptide binding]; other site 393133006318 metal binding site [ion binding]; metal-binding site 393133006319 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 393133006320 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 393133006321 Tetramer interface [polypeptide binding]; other site 393133006322 active site 393133006323 FMN-binding site [chemical binding]; other site 393133006324 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 393133006325 active site 393133006326 multimer interface [polypeptide binding]; other site 393133006327 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393133006328 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393133006329 substrate binding pocket [chemical binding]; other site 393133006330 chain length determination region; other site 393133006331 substrate-Mg2+ binding site; other site 393133006332 catalytic residues [active] 393133006333 aspartate-rich region 1; other site 393133006334 active site lid residues [active] 393133006335 aspartate-rich region 2; other site 393133006336 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 393133006337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133006338 S-adenosylmethionine binding site [chemical binding]; other site 393133006339 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 393133006340 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 393133006341 homodecamer interface [polypeptide binding]; other site 393133006342 GTP cyclohydrolase I; Provisional; Region: PLN03044 393133006343 active site 393133006344 putative catalytic site residues [active] 393133006345 zinc binding site [ion binding]; other site 393133006346 GTP-CH-I/GFRP interaction surface; other site 393133006347 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 393133006348 IHF dimer interface [polypeptide binding]; other site 393133006349 IHF - DNA interface [nucleotide binding]; other site 393133006350 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 393133006351 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 393133006352 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 393133006353 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 393133006354 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 393133006355 GTP-binding protein Der; Reviewed; Region: PRK00093 393133006356 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 393133006357 G1 box; other site 393133006358 GTP/Mg2+ binding site [chemical binding]; other site 393133006359 Switch I region; other site 393133006360 G2 box; other site 393133006361 Switch II region; other site 393133006362 G3 box; other site 393133006363 G4 box; other site 393133006364 G5 box; other site 393133006365 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 393133006366 G1 box; other site 393133006367 GTP/Mg2+ binding site [chemical binding]; other site 393133006368 Switch I region; other site 393133006369 G2 box; other site 393133006370 G3 box; other site 393133006371 Switch II region; other site 393133006372 G4 box; other site 393133006373 G5 box; other site 393133006374 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 393133006375 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 393133006376 RNA binding site [nucleotide binding]; other site 393133006377 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 393133006378 RNA binding site [nucleotide binding]; other site 393133006379 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 393133006380 RNA binding site [nucleotide binding]; other site 393133006381 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393133006382 RNA binding site [nucleotide binding]; other site 393133006383 cytidylate kinase; Provisional; Region: cmk; PRK00023 393133006384 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 393133006385 CMP-binding site; other site 393133006386 The sites determining sugar specificity; other site 393133006387 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 393133006388 active site 393133006389 homotetramer interface [polypeptide binding]; other site 393133006390 homodimer interface [polypeptide binding]; other site 393133006391 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133006392 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 393133006393 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 393133006394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133006395 ATP binding site [chemical binding]; other site 393133006396 putative Mg++ binding site [ion binding]; other site 393133006397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133006398 nucleotide binding region [chemical binding]; other site 393133006399 ATP-binding site [chemical binding]; other site 393133006400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 393133006401 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 393133006402 Predicted membrane protein [Function unknown]; Region: COG3601 393133006403 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 393133006404 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 393133006405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133006406 dimerization interface [polypeptide binding]; other site 393133006407 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 393133006408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133006409 dimer interface [polypeptide binding]; other site 393133006410 phosphorylation site [posttranslational modification] 393133006411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133006412 ATP binding site [chemical binding]; other site 393133006413 Mg2+ binding site [ion binding]; other site 393133006414 G-X-G motif; other site 393133006415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133006417 active site 393133006418 phosphorylation site [posttranslational modification] 393133006419 intermolecular recognition site; other site 393133006420 dimerization interface [polypeptide binding]; other site 393133006421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133006422 DNA binding site [nucleotide binding] 393133006423 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 393133006424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133006425 RNA binding surface [nucleotide binding]; other site 393133006426 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 393133006427 active site 393133006428 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 393133006429 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 393133006430 diaminopimelate decarboxylase; Region: lysA; TIGR01048 393133006431 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 393133006432 active site 393133006433 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393133006434 substrate binding site [chemical binding]; other site 393133006435 catalytic residues [active] 393133006436 dimer interface [polypeptide binding]; other site 393133006437 purine nucleoside phosphorylase; Provisional; Region: PRK08202 393133006438 phosphopentomutase; Provisional; Region: PRK05362 393133006439 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 393133006440 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 393133006441 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 393133006442 active site 393133006443 Int/Topo IB signature motif; other site 393133006444 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393133006445 metal binding site 2 [ion binding]; metal-binding site 393133006446 putative DNA binding helix; other site 393133006447 metal binding site 1 [ion binding]; metal-binding site 393133006448 dimer interface [polypeptide binding]; other site 393133006449 structural Zn2+ binding site [ion binding]; other site 393133006450 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393133006451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133006452 ABC-ATPase subunit interface; other site 393133006453 dimer interface [polypeptide binding]; other site 393133006454 putative PBP binding regions; other site 393133006455 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393133006456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133006457 ABC-ATPase subunit interface; other site 393133006458 dimer interface [polypeptide binding]; other site 393133006459 putative PBP binding regions; other site 393133006460 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 393133006461 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 393133006462 putative ligand binding residues [chemical binding]; other site 393133006463 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393133006464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393133006465 Walker A/P-loop; other site 393133006466 ATP binding site [chemical binding]; other site 393133006467 Q-loop/lid; other site 393133006468 ABC transporter signature motif; other site 393133006469 Walker B; other site 393133006470 D-loop; other site 393133006471 H-loop/switch region; other site 393133006472 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 393133006473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133006474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133006475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133006476 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 393133006477 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393133006478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133006479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133006480 Walker A/P-loop; other site 393133006481 ATP binding site [chemical binding]; other site 393133006482 Q-loop/lid; other site 393133006483 ABC transporter signature motif; other site 393133006484 Walker B; other site 393133006485 D-loop; other site 393133006486 H-loop/switch region; other site 393133006487 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 393133006488 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 393133006489 dimer interface [polypeptide binding]; other site 393133006490 ADP-ribose binding site [chemical binding]; other site 393133006491 active site 393133006492 nudix motif; other site 393133006493 metal binding site [ion binding]; metal-binding site 393133006494 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 393133006495 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 393133006496 Creatinine amidohydrolase; Region: Creatininase; pfam02633 393133006497 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 393133006498 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 393133006499 active site 393133006500 intersubunit interface [polypeptide binding]; other site 393133006501 catalytic residue [active] 393133006502 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 393133006503 active site 393133006504 substrate binding pocket [chemical binding]; other site 393133006505 homodimer interaction site [polypeptide binding]; other site 393133006506 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 393133006507 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 393133006508 active site 393133006509 P-loop; other site 393133006510 phosphorylation site [posttranslational modification] 393133006511 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133006512 active site 393133006513 phosphorylation site [posttranslational modification] 393133006514 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133006515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133006516 DNA-binding site [nucleotide binding]; DNA binding site 393133006517 UTRA domain; Region: UTRA; pfam07702 393133006518 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 393133006519 active site 393133006520 DNA polymerase IV; Validated; Region: PRK02406 393133006521 DNA binding site [nucleotide binding] 393133006522 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 393133006523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393133006524 NAD(P) binding site [chemical binding]; other site 393133006525 active site 393133006526 ribonuclease Z; Region: RNase_Z; TIGR02651 393133006527 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 393133006528 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 393133006529 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 393133006530 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 393133006531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393133006532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133006533 Coenzyme A binding pocket [chemical binding]; other site 393133006534 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 393133006535 6-phosphogluconate dehydratase; Region: edd; TIGR01196 393133006536 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 393133006537 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393133006538 PYR/PP interface [polypeptide binding]; other site 393133006539 dimer interface [polypeptide binding]; other site 393133006540 TPP binding site [chemical binding]; other site 393133006541 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393133006542 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 393133006543 TPP-binding site [chemical binding]; other site 393133006544 dimer interface [polypeptide binding]; other site 393133006545 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 393133006546 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 393133006547 putative valine binding site [chemical binding]; other site 393133006548 dimer interface [polypeptide binding]; other site 393133006549 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 393133006550 ketol-acid reductoisomerase; Provisional; Region: PRK05479 393133006551 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 393133006552 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 393133006553 2-isopropylmalate synthase; Validated; Region: PRK00915 393133006554 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 393133006555 active site 393133006556 catalytic residues [active] 393133006557 metal binding site [ion binding]; metal-binding site 393133006558 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 393133006559 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 393133006560 tartrate dehydrogenase; Region: TTC; TIGR02089 393133006561 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 393133006562 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 393133006563 substrate binding site [chemical binding]; other site 393133006564 ligand binding site [chemical binding]; other site 393133006565 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 393133006566 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 393133006567 substrate binding site [chemical binding]; other site 393133006568 threonine dehydratase; Validated; Region: PRK08639 393133006569 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 393133006570 tetramer interface [polypeptide binding]; other site 393133006571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133006572 catalytic residue [active] 393133006573 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 393133006574 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 393133006575 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 393133006576 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 393133006577 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 393133006578 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 393133006579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133006580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133006581 DNA binding site [nucleotide binding] 393133006582 domain linker motif; other site 393133006583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133006584 dimerization interface [polypeptide binding]; other site 393133006585 ligand binding site [chemical binding]; other site 393133006586 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 393133006587 intersubunit interface [polypeptide binding]; other site 393133006588 active site 393133006589 catalytic residue [active] 393133006590 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393133006591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 393133006592 DNA binding residues [nucleotide binding] 393133006593 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393133006594 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393133006595 active pocket/dimerization site; other site 393133006596 active site 393133006597 phosphorylation site [posttranslational modification] 393133006598 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393133006599 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 393133006600 putative active site [active] 393133006601 SIS domain; Region: SIS; pfam01380 393133006602 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393133006603 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393133006604 dimer interface [polypeptide binding]; other site 393133006605 active site 393133006606 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393133006607 dimer interface [polypeptide binding]; other site 393133006608 active site 393133006609 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 393133006610 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 393133006611 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393133006612 active site 393133006613 phosphorylation site [posttranslational modification] 393133006614 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133006615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133006616 DNA-binding site [nucleotide binding]; DNA binding site 393133006617 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393133006618 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133006619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133006620 DNA-binding site [nucleotide binding]; DNA binding site 393133006621 UTRA domain; Region: UTRA; pfam07702 393133006622 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133006623 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133006624 active site 393133006625 catalytic tetrad [active] 393133006626 acetolactate synthase; Reviewed; Region: PRK08617 393133006627 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393133006628 PYR/PP interface [polypeptide binding]; other site 393133006629 dimer interface [polypeptide binding]; other site 393133006630 TPP binding site [chemical binding]; other site 393133006631 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393133006632 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 393133006633 TPP-binding site [chemical binding]; other site 393133006634 dimer interface [polypeptide binding]; other site 393133006635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133006636 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 393133006637 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 393133006638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133006639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133006640 dimer interface [polypeptide binding]; other site 393133006641 conserved gate region; other site 393133006642 ABC-ATPase subunit interface; other site 393133006643 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393133006644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133006645 dimer interface [polypeptide binding]; other site 393133006646 conserved gate region; other site 393133006647 ABC-ATPase subunit interface; other site 393133006648 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 393133006649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133006650 active site 393133006651 phosphorylation site [posttranslational modification] 393133006652 intermolecular recognition site; other site 393133006653 dimerization interface [polypeptide binding]; other site 393133006654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133006655 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 393133006656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133006657 dimerization interface [polypeptide binding]; other site 393133006658 Histidine kinase; Region: His_kinase; pfam06580 393133006659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133006660 ATP binding site [chemical binding]; other site 393133006661 Mg2+ binding site [ion binding]; other site 393133006662 G-X-G motif; other site 393133006663 Predicted integral membrane protein [Function unknown]; Region: COG5578 393133006664 Uncharacterized conserved protein [Function unknown]; Region: COG3538 393133006665 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 393133006666 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393133006667 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 393133006668 active site 393133006669 metal binding site [ion binding]; metal-binding site 393133006670 homodimer interface [polypeptide binding]; other site 393133006671 catalytic site [active] 393133006672 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393133006673 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393133006674 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 393133006675 active site 393133006676 catalytic site [active] 393133006677 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393133006678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393133006679 DNA-binding site [nucleotide binding]; DNA binding site 393133006680 RNA-binding motif; other site 393133006681 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 393133006682 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 393133006683 active site 393133006684 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 393133006685 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393133006686 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393133006687 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 393133006688 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 393133006689 HIGH motif; other site 393133006690 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 393133006691 active site 393133006692 KMSKS motif; other site 393133006693 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 393133006694 tRNA binding surface [nucleotide binding]; other site 393133006695 anticodon binding site; other site 393133006696 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393133006697 DivIVA protein; Region: DivIVA; pfam05103 393133006698 DivIVA domain; Region: DivI1A_domain; TIGR03544 393133006699 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 393133006700 HTH domain; Region: HTH_11; pfam08279 393133006701 3H domain; Region: 3H; pfam02829 393133006702 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393133006703 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393133006704 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393133006705 catalytic residue [active] 393133006706 L-aspartate oxidase; Provisional; Region: PRK08071 393133006707 L-aspartate oxidase; Provisional; Region: PRK06175 393133006708 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 393133006709 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 393133006710 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 393133006711 dimerization interface [polypeptide binding]; other site 393133006712 active site 393133006713 quinolinate synthetase; Provisional; Region: PRK09375 393133006714 Leucine rich repeat; Region: LRR_8; pfam13855 393133006715 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133006716 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133006717 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393133006718 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133006719 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133006720 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 393133006721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133006722 RNA binding surface [nucleotide binding]; other site 393133006723 YGGT family; Region: YGGT; pfam02325 393133006724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 393133006725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 393133006726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393133006727 catalytic residue [active] 393133006728 cell division protein FtsZ; Validated; Region: PRK09330 393133006729 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 393133006730 nucleotide binding site [chemical binding]; other site 393133006731 SulA interaction site; other site 393133006732 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 393133006733 Cell division protein FtsA; Region: FtsA; smart00842 393133006734 Cell division protein FtsA; Region: FtsA; pfam14450 393133006735 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 393133006736 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 393133006737 Cell division protein FtsQ; Region: FtsQ; pfam03799 393133006738 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 393133006739 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 393133006740 active site 393133006741 homodimer interface [polypeptide binding]; other site 393133006742 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 393133006743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393133006744 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393133006745 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 393133006746 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 393133006747 Mg++ binding site [ion binding]; other site 393133006748 putative catalytic motif [active] 393133006749 putative substrate binding site [chemical binding]; other site 393133006750 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 393133006751 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393133006752 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393133006753 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393133006754 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 393133006755 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393133006756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393133006757 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 393133006758 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 393133006759 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 393133006760 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 393133006761 MraW methylase family; Region: Methyltransf_5; pfam01795 393133006762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 393133006763 MraZ protein; Region: MraZ; pfam02381 393133006764 MraZ protein; Region: MraZ; pfam02381 393133006765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133006766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133006767 putative substrate translocation pore; other site 393133006768 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 393133006769 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 393133006770 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 393133006771 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 393133006772 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 393133006773 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 393133006774 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 393133006775 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 393133006776 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 393133006777 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 393133006778 hypothetical protein; Provisional; Region: PRK13670 393133006779 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393133006780 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393133006781 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 393133006782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133006783 Walker A/P-loop; other site 393133006784 ATP binding site [chemical binding]; other site 393133006785 Q-loop/lid; other site 393133006786 ABC transporter signature motif; other site 393133006787 Walker B; other site 393133006788 D-loop; other site 393133006789 H-loop/switch region; other site 393133006790 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 393133006791 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 393133006792 protein binding site [polypeptide binding]; other site 393133006793 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 393133006794 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 393133006795 active site 393133006796 (T/H)XGH motif; other site 393133006797 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 393133006798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133006799 S-adenosylmethionine binding site [chemical binding]; other site 393133006800 hypothetical protein; Provisional; Region: PRK02886 393133006801 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 393133006802 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 393133006803 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 393133006804 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 393133006805 UbiA prenyltransferase family; Region: UbiA; pfam01040 393133006806 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 393133006807 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 393133006808 Ion transport protein; Region: Ion_trans; pfam00520 393133006809 Ion channel; Region: Ion_trans_2; pfam07885 393133006810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 393133006811 MOSC domain; Region: MOSC; pfam03473 393133006812 3-alpha domain; Region: 3-alpha; pfam03475 393133006813 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 393133006814 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 393133006815 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 393133006816 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 393133006817 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 393133006818 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 393133006819 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 393133006820 active site 393133006821 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 393133006822 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 393133006823 ring oligomerisation interface [polypeptide binding]; other site 393133006824 ATP/Mg binding site [chemical binding]; other site 393133006825 stacking interactions; other site 393133006826 hinge regions; other site 393133006827 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 393133006828 oligomerisation interface [polypeptide binding]; other site 393133006829 mobile loop; other site 393133006830 roof hairpin; other site 393133006831 CAAX protease self-immunity; Region: Abi; pfam02517 393133006832 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 393133006833 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 393133006834 CoA binding domain; Region: CoA_binding; pfam02629 393133006835 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393133006836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133006837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133006838 ABC transporter; Region: ABC_tran_2; pfam12848 393133006839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133006840 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133006841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 393133006842 UGMP family protein; Validated; Region: PRK09604 393133006843 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 393133006844 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 393133006845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133006846 Coenzyme A binding pocket [chemical binding]; other site 393133006847 Glycoprotease family; Region: Peptidase_M22; pfam00814 393133006848 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 393133006849 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 393133006850 camphor resistance protein CrcB; Provisional; Region: PRK14214 393133006851 camphor resistance protein CrcB; Provisional; Region: PRK14231 393133006852 Uncharacterized conserved protein [Function unknown]; Region: COG4832 393133006853 Phosphotransferase enzyme family; Region: APH; pfam01636 393133006854 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 393133006855 active site 393133006856 substrate binding site [chemical binding]; other site 393133006857 ATP binding site [chemical binding]; other site 393133006858 Cna protein B-type domain; Region: Cna_B; pfam05738 393133006859 Cna protein B-type domain; Region: Cna_B; pfam05738 393133006860 Cna protein B-type domain; Region: Cna_B; pfam05738 393133006861 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133006862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133006863 non-specific DNA binding site [nucleotide binding]; other site 393133006864 salt bridge; other site 393133006865 sequence-specific DNA binding site [nucleotide binding]; other site 393133006866 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393133006867 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393133006868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133006869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133006870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 393133006871 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393133006872 substrate binding pocket [chemical binding]; other site 393133006873 argininosuccinate synthase; Provisional; Region: PRK13820 393133006874 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 393133006875 ANP binding site [chemical binding]; other site 393133006876 Substrate Binding Site II [chemical binding]; other site 393133006877 Substrate Binding Site I [chemical binding]; other site 393133006878 argininosuccinate lyase; Provisional; Region: PRK00855 393133006879 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 393133006880 active sites [active] 393133006881 tetramer interface [polypeptide binding]; other site 393133006882 BCCT family transporter; Region: BCCT; pfam02028 393133006883 hypothetical protein; Provisional; Region: PRK06357 393133006884 active site 393133006885 intersubunit interface [polypeptide binding]; other site 393133006886 Zn2+ binding site [ion binding]; other site 393133006887 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 393133006888 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 393133006889 putative substrate binding site [chemical binding]; other site 393133006890 putative ATP binding site [chemical binding]; other site 393133006891 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393133006892 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393133006893 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393133006894 active site 393133006895 P-loop; other site 393133006896 phosphorylation site [posttranslational modification] 393133006897 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133006898 active site 393133006899 phosphorylation site [posttranslational modification] 393133006900 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133006901 PRD domain; Region: PRD; pfam00874 393133006902 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133006903 active site 393133006904 P-loop; other site 393133006905 phosphorylation site [posttranslational modification] 393133006906 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 393133006907 active site 393133006908 phosphorylation site [posttranslational modification] 393133006909 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 393133006910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133006911 DNA-binding site [nucleotide binding]; DNA binding site 393133006912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133006913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133006914 homodimer interface [polypeptide binding]; other site 393133006915 catalytic residue [active] 393133006916 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 393133006917 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 393133006918 active site 393133006919 multimer interface [polypeptide binding]; other site 393133006920 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 393133006921 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 393133006922 predicted active site [active] 393133006923 catalytic triad [active] 393133006924 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 393133006925 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 393133006926 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 393133006927 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 393133006928 G1 box; other site 393133006929 GTP/Mg2+ binding site [chemical binding]; other site 393133006930 Switch I region; other site 393133006931 G2 box; other site 393133006932 G3 box; other site 393133006933 Switch II region; other site 393133006934 G4 box; other site 393133006935 G5 box; other site 393133006936 Nucleoside recognition; Region: Gate; pfam07670 393133006937 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 393133006938 Nucleoside recognition; Region: Gate; pfam07670 393133006939 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 393133006940 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393133006941 putative active site [active] 393133006942 putative metal binding site [ion binding]; other site 393133006943 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133006944 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 393133006945 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133006946 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 393133006947 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 393133006948 active site 393133006949 dimer interface [polypeptide binding]; other site 393133006950 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393133006951 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 393133006952 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 393133006953 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 393133006954 dimer interface [polypeptide binding]; other site 393133006955 FMN binding site [chemical binding]; other site 393133006956 NADPH bind site [chemical binding]; other site 393133006957 Helix-turn-helix domain; Region: HTH_17; pfam12728 393133006958 putative heme peroxidase; Provisional; Region: PRK12276 393133006959 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133006960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133006961 Walker A/P-loop; other site 393133006962 ATP binding site [chemical binding]; other site 393133006963 Q-loop/lid; other site 393133006964 ABC transporter signature motif; other site 393133006965 Walker B; other site 393133006966 D-loop; other site 393133006967 H-loop/switch region; other site 393133006968 FtsX-like permease family; Region: FtsX; pfam02687 393133006969 FtsX-like permease family; Region: FtsX; pfam02687 393133006970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133006971 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133006972 Coenzyme A binding pocket [chemical binding]; other site 393133006973 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 393133006974 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 393133006975 active site 393133006976 substrate binding site [chemical binding]; other site 393133006977 metal binding site [ion binding]; metal-binding site 393133006978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 393133006979 YbbR-like protein; Region: YbbR; pfam07949 393133006980 YbbR-like protein; Region: YbbR; pfam07949 393133006981 YbbR-like protein; Region: YbbR; pfam07949 393133006982 Uncharacterized conserved protein [Function unknown]; Region: COG1624 393133006983 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 393133006984 maltose phosphorylase; Provisional; Region: PRK13807 393133006985 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 393133006986 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 393133006987 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 393133006988 Predicted integral membrane protein [Function unknown]; Region: COG5521 393133006989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133006990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133006991 dimer interface [polypeptide binding]; other site 393133006992 conserved gate region; other site 393133006993 putative PBP binding loops; other site 393133006994 ABC-ATPase subunit interface; other site 393133006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133006996 dimer interface [polypeptide binding]; other site 393133006997 conserved gate region; other site 393133006998 putative PBP binding loops; other site 393133006999 ABC-ATPase subunit interface; other site 393133007000 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 393133007001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133007002 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 393133007003 homodimer interface [polypeptide binding]; other site 393133007004 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 393133007005 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 393133007006 active site 393133007007 homodimer interface [polypeptide binding]; other site 393133007008 catalytic site [active] 393133007009 CAAX protease self-immunity; Region: Abi; cl00558 393133007010 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133007011 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133007012 DNA binding site [nucleotide binding] 393133007013 domain linker motif; other site 393133007014 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393133007015 ligand binding site [chemical binding]; other site 393133007016 dimerization interface [polypeptide binding]; other site 393133007017 Amino acid permease; Region: AA_permease_2; pfam13520 393133007018 K+ potassium transporter; Region: K_trans; cl15781 393133007019 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133007020 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133007021 ligand binding site [chemical binding]; other site 393133007022 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133007023 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393133007024 ligand binding site [chemical binding]; other site 393133007025 flexible hinge region; other site 393133007026 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133007027 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393133007028 intersubunit interface [polypeptide binding]; other site 393133007029 active site 393133007030 zinc binding site [ion binding]; other site 393133007031 Na+ binding site [ion binding]; other site 393133007032 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393133007033 intersubunit interface [polypeptide binding]; other site 393133007034 active site 393133007035 zinc binding site [ion binding]; other site 393133007036 Na+ binding site [ion binding]; other site 393133007037 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133007038 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133007039 active site 393133007040 P-loop; other site 393133007041 phosphorylation site [posttranslational modification] 393133007042 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133007043 active site 393133007044 phosphorylation site [posttranslational modification] 393133007045 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133007046 HTH domain; Region: HTH_11; pfam08279 393133007047 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133007048 PRD domain; Region: PRD; pfam00874 393133007049 PRD domain; Region: PRD; pfam00874 393133007050 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133007051 active site 393133007052 P-loop; other site 393133007053 phosphorylation site [posttranslational modification] 393133007054 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 393133007055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133007056 Walker A/P-loop; other site 393133007057 ATP binding site [chemical binding]; other site 393133007058 Q-loop/lid; other site 393133007059 ABC transporter signature motif; other site 393133007060 Walker B; other site 393133007061 D-loop; other site 393133007062 H-loop/switch region; other site 393133007063 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 393133007064 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 393133007065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 393133007066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133007067 Coenzyme A binding pocket [chemical binding]; other site 393133007068 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393133007069 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 393133007070 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 393133007071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393133007072 putative transposase OrfB; Reviewed; Region: PHA02517 393133007073 HTH-like domain; Region: HTH_21; pfam13276 393133007074 Integrase core domain; Region: rve; pfam00665 393133007075 Integrase core domain; Region: rve_3; cl15866 393133007076 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393133007077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133007078 DNA-binding site [nucleotide binding]; DNA binding site 393133007079 UTRA domain; Region: UTRA; pfam07702 393133007080 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 393133007081 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 393133007082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133007083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133007084 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 393133007085 putative dimerization interface [polypeptide binding]; other site 393133007086 Predicted membrane protein [Function unknown]; Region: COG2855 393133007087 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 393133007088 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 393133007089 putative metal binding site [ion binding]; other site 393133007090 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 393133007091 homodimer interface [polypeptide binding]; other site 393133007092 chemical substrate binding site [chemical binding]; other site 393133007093 oligomer interface [polypeptide binding]; other site 393133007094 metal binding site [ion binding]; metal-binding site 393133007095 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133007096 catalytic residues [active] 393133007097 flavodoxin; Provisional; Region: PRK09271 393133007098 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 393133007099 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 393133007100 dimer interface [polypeptide binding]; other site 393133007101 putative radical transfer pathway; other site 393133007102 diiron center [ion binding]; other site 393133007103 tyrosyl radical; other site 393133007104 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 393133007105 Class I ribonucleotide reductase; Region: RNR_I; cd01679 393133007106 active site 393133007107 dimer interface [polypeptide binding]; other site 393133007108 catalytic residues [active] 393133007109 effector binding site; other site 393133007110 R2 peptide binding site; other site 393133007111 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 393133007112 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 393133007113 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393133007114 CsbD-like; Region: CsbD; cl17424 393133007115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133007116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133007117 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393133007118 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393133007119 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 393133007120 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 393133007121 conserved cys residue [active] 393133007122 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393133007123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133007124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133007125 Cupin domain; Region: Cupin_2; cl17218 393133007126 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133007127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133007128 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133007129 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 393133007130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133007131 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133007132 ligand binding site [chemical binding]; other site 393133007133 flexible hinge region; other site 393133007134 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 393133007135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393133007136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133007137 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 393133007138 dimer interface [polypeptide binding]; other site 393133007139 active site 393133007140 metal binding site [ion binding]; metal-binding site 393133007141 glutathione binding site [chemical binding]; other site 393133007142 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 393133007143 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 393133007144 FMN binding site [chemical binding]; other site 393133007145 substrate binding site [chemical binding]; other site 393133007146 putative catalytic residue [active] 393133007147 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 393133007148 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 393133007149 Coenzyme A transferase; Region: CoA_trans; smart00882 393133007150 Coenzyme A transferase; Region: CoA_trans; cl17247 393133007151 PAS domain; Region: PAS_9; pfam13426 393133007152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133007153 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 393133007154 Walker A motif; other site 393133007155 ATP binding site [chemical binding]; other site 393133007156 Walker B motif; other site 393133007157 arginine finger; other site 393133007158 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 393133007159 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 393133007160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393133007161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393133007162 metal binding site [ion binding]; metal-binding site 393133007163 active site 393133007164 I-site; other site 393133007165 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 393133007166 classical (c) SDRs; Region: SDR_c; cd05233 393133007167 NAD(P) binding site [chemical binding]; other site 393133007168 active site 393133007169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133007170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133007171 Tic20-like protein; Region: Tic20; pfam09685 393133007172 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393133007173 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007174 Collagen binding domain; Region: Collagen_bind; pfam05737 393133007175 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007176 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007177 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007178 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007179 Cna protein B-type domain; Region: Cna_B; pfam05738 393133007180 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007181 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007182 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007183 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 393133007184 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 393133007185 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 393133007186 active site 393133007187 catalytic site [active] 393133007188 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393133007189 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393133007190 Walker A/P-loop; other site 393133007191 ATP binding site [chemical binding]; other site 393133007192 Q-loop/lid; other site 393133007193 ABC transporter signature motif; other site 393133007194 Walker B; other site 393133007195 D-loop; other site 393133007196 H-loop/switch region; other site 393133007197 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393133007198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133007199 ABC-ATPase subunit interface; other site 393133007200 dimer interface [polypeptide binding]; other site 393133007201 putative PBP binding regions; other site 393133007202 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 393133007203 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 393133007204 putative ligand binding residues [chemical binding]; other site 393133007205 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393133007206 heme-binding site [chemical binding]; other site 393133007207 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 393133007208 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393133007209 heme-binding site [chemical binding]; other site 393133007210 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393133007211 heme-binding site [chemical binding]; other site 393133007212 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 393133007213 heme uptake protein IsdC; Region: IsdC; TIGR03656 393133007214 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393133007215 heme-binding site [chemical binding]; other site 393133007216 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 393133007217 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393133007218 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 393133007219 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 393133007220 active site 393133007221 Zn binding site [ion binding]; other site 393133007222 Competence protein CoiA-like family; Region: CoiA; cl11541 393133007223 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 393133007224 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 393133007225 ArsC family; Region: ArsC; pfam03960 393133007226 putative catalytic residues [active] 393133007227 thiol/disulfide switch; other site 393133007228 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 393133007229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 393133007230 Walker A/P-loop; other site 393133007231 ATP binding site [chemical binding]; other site 393133007232 Q-loop/lid; other site 393133007233 ABC transporter signature motif; other site 393133007234 Walker B; other site 393133007235 D-loop; other site 393133007236 H-loop/switch region; other site 393133007237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 393133007238 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 393133007239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 393133007240 Walker A/P-loop; other site 393133007241 ATP binding site [chemical binding]; other site 393133007242 Q-loop/lid; other site 393133007243 ABC transporter signature motif; other site 393133007244 Walker B; other site 393133007245 D-loop; other site 393133007246 H-loop/switch region; other site 393133007247 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 393133007248 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393133007249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007250 dimer interface [polypeptide binding]; other site 393133007251 conserved gate region; other site 393133007252 putative PBP binding loops; other site 393133007253 ABC-ATPase subunit interface; other site 393133007254 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393133007255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007256 dimer interface [polypeptide binding]; other site 393133007257 conserved gate region; other site 393133007258 putative PBP binding loops; other site 393133007259 ABC-ATPase subunit interface; other site 393133007260 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393133007261 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393133007262 peptide binding site [polypeptide binding]; other site 393133007263 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 393133007264 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 393133007265 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 393133007266 active site 393133007267 HIGH motif; other site 393133007268 dimer interface [polypeptide binding]; other site 393133007269 KMSKS motif; other site 393133007270 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 393133007271 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133007272 MarR family; Region: MarR; pfam01047 393133007273 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 393133007274 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 393133007275 dimer interface [polypeptide binding]; other site 393133007276 active site 393133007277 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 393133007278 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 393133007279 dimer interface [polypeptide binding]; other site 393133007280 active site 393133007281 CoA binding pocket [chemical binding]; other site 393133007282 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133007283 SH3-like domain; Region: SH3_8; pfam13457 393133007284 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 393133007285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133007286 catalytic core [active] 393133007287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393133007288 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 393133007289 Clp amino terminal domain; Region: Clp_N; pfam02861 393133007290 Clp amino terminal domain; Region: Clp_N; pfam02861 393133007291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133007292 Walker A motif; other site 393133007293 ATP binding site [chemical binding]; other site 393133007294 Walker B motif; other site 393133007295 arginine finger; other site 393133007296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133007297 Walker A motif; other site 393133007298 ATP binding site [chemical binding]; other site 393133007299 Walker B motif; other site 393133007300 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 393133007301 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 393133007302 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 393133007303 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133007304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007305 active site 393133007306 motif I; other site 393133007307 motif II; other site 393133007308 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393133007309 Predicted acetyltransferase [General function prediction only]; Region: COG3393 393133007310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 393133007311 ferrochelatase; Provisional; Region: PRK12435 393133007312 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 393133007313 C-terminal domain interface [polypeptide binding]; other site 393133007314 active site 393133007315 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 393133007316 active site 393133007317 N-terminal domain interface [polypeptide binding]; other site 393133007318 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 393133007319 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 393133007320 substrate binding site [chemical binding]; other site 393133007321 active site 393133007322 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 393133007323 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 393133007324 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393133007325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133007326 Walker A/P-loop; other site 393133007327 ATP binding site [chemical binding]; other site 393133007328 Q-loop/lid; other site 393133007329 ABC transporter signature motif; other site 393133007330 Walker B; other site 393133007331 D-loop; other site 393133007332 H-loop/switch region; other site 393133007333 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 393133007334 HIT family signature motif; other site 393133007335 catalytic residue [active] 393133007336 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 393133007337 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 393133007338 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 393133007339 SurA N-terminal domain; Region: SurA_N_3; cl07813 393133007340 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 393133007341 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 393133007342 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 393133007343 generic binding surface II; other site 393133007344 generic binding surface I; other site 393133007345 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133007346 Zn2+ binding site [ion binding]; other site 393133007347 Mg2+ binding site [ion binding]; other site 393133007348 Uncharacterized conserved protein [Function unknown]; Region: COG4717 393133007349 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 393133007350 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 393133007351 active site 393133007352 metal binding site [ion binding]; metal-binding site 393133007353 DNA binding site [nucleotide binding] 393133007354 hypothetical protein; Provisional; Region: PRK13676 393133007355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 393133007356 fumarate hydratase; Reviewed; Region: fumC; PRK00485 393133007357 Class II fumarases; Region: Fumarase_classII; cd01362 393133007358 active site 393133007359 tetramer interface [polypeptide binding]; other site 393133007360 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 393133007361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133007362 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133007363 Walker A/P-loop; other site 393133007364 ATP binding site [chemical binding]; other site 393133007365 Q-loop/lid; other site 393133007366 ABC transporter signature motif; other site 393133007367 Walker B; other site 393133007368 D-loop; other site 393133007369 H-loop/switch region; other site 393133007370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 393133007371 Transglycosylase; Region: Transgly; pfam00912 393133007372 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 393133007373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393133007374 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393133007375 Low molecular weight phosphatase family; Region: LMWPc; cl00105 393133007376 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393133007377 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 393133007378 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393133007379 Domain of unknown function DUF21; Region: DUF21; pfam01595 393133007380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393133007381 Transporter associated domain; Region: CorC_HlyC; smart01091 393133007382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133007383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133007384 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393133007385 putative dimerization interface [polypeptide binding]; other site 393133007386 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 393133007387 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 393133007388 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 393133007389 active site 393133007390 FMN binding site [chemical binding]; other site 393133007391 substrate binding site [chemical binding]; other site 393133007392 putative catalytic residue [active] 393133007393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133007394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133007395 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 393133007396 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393133007397 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393133007398 shikimate binding site; other site 393133007399 NAD(P) binding site [chemical binding]; other site 393133007400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133007401 putative substrate translocation pore; other site 393133007402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133007404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133007405 putative substrate translocation pore; other site 393133007406 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393133007407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133007408 Walker A/P-loop; other site 393133007409 ATP binding site [chemical binding]; other site 393133007410 Q-loop/lid; other site 393133007411 ABC transporter signature motif; other site 393133007412 Walker B; other site 393133007413 D-loop; other site 393133007414 H-loop/switch region; other site 393133007415 Predicted transcriptional regulators [Transcription]; Region: COG1725 393133007416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393133007417 DNA-binding site [nucleotide binding]; DNA binding site 393133007418 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393133007419 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393133007420 DNA binding site [nucleotide binding] 393133007421 active site 393133007422 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 393133007423 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 393133007424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133007425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133007426 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393133007427 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393133007428 active site 393133007429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 393133007430 putative dimer interface [polypeptide binding]; other site 393133007431 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133007432 ligand binding site [chemical binding]; other site 393133007433 Zn binding site [ion binding]; other site 393133007434 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 393133007435 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 393133007436 active site 393133007437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133007438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133007439 active site 393133007440 catalytic tetrad [active] 393133007441 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 393133007442 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 393133007443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393133007444 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393133007445 substrate binding pocket [chemical binding]; other site 393133007446 membrane-bound complex binding site; other site 393133007447 hinge residues; other site 393133007448 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393133007449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007450 dimer interface [polypeptide binding]; other site 393133007451 conserved gate region; other site 393133007452 putative PBP binding loops; other site 393133007453 ABC-ATPase subunit interface; other site 393133007454 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393133007455 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393133007456 Walker A/P-loop; other site 393133007457 ATP binding site [chemical binding]; other site 393133007458 Q-loop/lid; other site 393133007459 ABC transporter signature motif; other site 393133007460 Walker B; other site 393133007461 D-loop; other site 393133007462 H-loop/switch region; other site 393133007463 aspartate aminotransferase; Provisional; Region: PRK06348 393133007464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133007465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133007466 homodimer interface [polypeptide binding]; other site 393133007467 catalytic residue [active] 393133007468 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 393133007469 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393133007470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007471 motif II; other site 393133007472 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393133007473 intracellular protease, PfpI family; Region: PfpI; TIGR01382 393133007474 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 393133007475 proposed catalytic triad [active] 393133007476 conserved cys residue [active] 393133007477 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 393133007478 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133007479 methionine cluster; other site 393133007480 active site 393133007481 phosphorylation site [posttranslational modification] 393133007482 metal binding site [ion binding]; metal-binding site 393133007483 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 393133007484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133007485 Coenzyme A binding pocket [chemical binding]; other site 393133007486 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 393133007487 esterase; Provisional; Region: PRK10566 393133007488 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 393133007489 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133007490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 393133007491 motif II; other site 393133007492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007493 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393133007494 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133007495 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133007496 hypothetical protein; Provisional; Region: PRK13673 393133007497 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 393133007498 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 393133007499 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 393133007500 Part of AAA domain; Region: AAA_19; pfam13245 393133007501 Family description; Region: UvrD_C_2; pfam13538 393133007502 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 393133007503 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 393133007504 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 393133007505 IDEAL domain; Region: IDEAL; pfam08858 393133007506 ComK protein; Region: ComK; cl11560 393133007507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 393133007508 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 393133007509 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 393133007510 Phage holin; Region: Phage_holin_5; pfam06946 393133007511 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 393133007512 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 393133007513 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 393133007514 Phage tail protein; Region: Sipho_tail; pfam05709 393133007515 tape measure domain; Region: tape_meas_nterm; TIGR02675 393133007516 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 393133007517 Phage protein Gp14; Region: Phage_Gp14; pfam10666 393133007518 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 393133007519 Minor capsid protein; Region: Minor_capsid_2; pfam11114 393133007520 Minor capsid protein; Region: Minor_capsid_1; pfam10665 393133007521 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 393133007522 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 393133007523 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 393133007524 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 393133007525 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 393133007526 Phage terminase large subunit; Region: Terminase_3; pfam04466 393133007527 Terminase-like family; Region: Terminase_6; pfam03237 393133007528 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 393133007529 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 393133007530 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 393133007531 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 393133007532 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 393133007533 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 393133007534 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 393133007535 AntA/AntB antirepressor; Region: AntA; pfam08346 393133007536 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 393133007537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133007538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133007539 non-specific DNA binding site [nucleotide binding]; other site 393133007540 salt bridge; other site 393133007541 sequence-specific DNA binding site [nucleotide binding]; other site 393133007542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133007543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133007544 non-specific DNA binding site [nucleotide binding]; other site 393133007545 salt bridge; other site 393133007546 sequence-specific DNA binding site [nucleotide binding]; other site 393133007547 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 393133007548 Divergent AAA domain; Region: AAA_4; pfam04326 393133007549 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 393133007550 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 393133007551 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 393133007552 catalytic residues [active] 393133007553 catalytic nucleophile [active] 393133007554 Presynaptic Site I dimer interface [polypeptide binding]; other site 393133007555 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 393133007556 Synaptic Flat tetramer interface [polypeptide binding]; other site 393133007557 Synaptic Site I dimer interface [polypeptide binding]; other site 393133007558 DNA binding site [nucleotide binding] 393133007559 Recombinase; Region: Recombinase; pfam07508 393133007560 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 393133007561 ComK protein; Region: ComK; cl11560 393133007562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393133007563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133007564 non-specific DNA binding site [nucleotide binding]; other site 393133007565 salt bridge; other site 393133007566 sequence-specific DNA binding site [nucleotide binding]; other site 393133007567 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 393133007568 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133007569 active site 393133007570 phosphorylation site [posttranslational modification] 393133007571 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133007572 active site 393133007573 P-loop; other site 393133007574 phosphorylation site [posttranslational modification] 393133007575 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133007576 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 393133007577 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 393133007578 putative substrate binding site [chemical binding]; other site 393133007579 putative ATP binding site [chemical binding]; other site 393133007580 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133007581 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 393133007582 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133007583 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 393133007584 trimer interface [polypeptide binding]; other site 393133007585 active site 393133007586 G bulge; other site 393133007587 Uncharacterized conserved protein [Function unknown]; Region: COG1683 393133007588 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 393133007589 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393133007590 non-specific DNA interactions [nucleotide binding]; other site 393133007591 DNA binding site [nucleotide binding] 393133007592 sequence specific DNA binding site [nucleotide binding]; other site 393133007593 putative cAMP binding site [chemical binding]; other site 393133007594 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 393133007595 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 393133007596 substrate binding site [chemical binding]; other site 393133007597 ATP binding site [chemical binding]; other site 393133007598 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 393133007599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393133007600 RNA binding surface [nucleotide binding]; other site 393133007601 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 393133007602 active site 393133007603 uracil binding [chemical binding]; other site 393133007604 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 393133007605 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 393133007606 active site 393133007607 non-prolyl cis peptide bond; other site 393133007608 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 393133007609 catalytic residues [active] 393133007610 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 393133007611 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 393133007612 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393133007613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393133007614 Walker A/P-loop; other site 393133007615 ATP binding site [chemical binding]; other site 393133007616 Q-loop/lid; other site 393133007617 ABC transporter signature motif; other site 393133007618 Walker B; other site 393133007619 D-loop; other site 393133007620 H-loop/switch region; other site 393133007621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393133007622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007623 dimer interface [polypeptide binding]; other site 393133007624 conserved gate region; other site 393133007625 putative PBP binding loops; other site 393133007626 ABC-ATPase subunit interface; other site 393133007627 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393133007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007629 dimer interface [polypeptide binding]; other site 393133007630 conserved gate region; other site 393133007631 putative PBP binding loops; other site 393133007632 ABC-ATPase subunit interface; other site 393133007633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393133007634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393133007635 substrate binding pocket [chemical binding]; other site 393133007636 membrane-bound complex binding site; other site 393133007637 hinge residues; other site 393133007638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133007639 Coenzyme A binding pocket [chemical binding]; other site 393133007640 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393133007641 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393133007642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393133007643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393133007644 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393133007645 dimerization interface [polypeptide binding]; other site 393133007646 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393133007647 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 393133007648 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 393133007649 active site 393133007650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133007651 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133007653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133007654 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 393133007655 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393133007656 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393133007657 active site 393133007658 trimer interface [polypeptide binding]; other site 393133007659 allosteric site; other site 393133007660 active site lid [active] 393133007661 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393133007662 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133007663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007664 active site 393133007665 motif I; other site 393133007666 motif II; other site 393133007667 Predicted membrane protein [Function unknown]; Region: COG1511 393133007668 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393133007669 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 393133007670 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 393133007671 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 393133007672 Predicted transcriptional regulator [Transcription]; Region: COG1959 393133007673 Transcriptional regulator; Region: Rrf2; pfam02082 393133007674 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 393133007675 L-tyrosine decarboxylase; Provisional; Region: PRK13520 393133007676 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393133007677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133007678 catalytic residue [active] 393133007679 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 393133007680 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133007681 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 393133007682 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393133007683 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 393133007684 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393133007685 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 393133007686 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 393133007687 active site 393133007688 dimer interface [polypeptide binding]; other site 393133007689 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 393133007690 dimer interface [polypeptide binding]; other site 393133007691 active site 393133007692 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 393133007693 nudix motif; other site 393133007694 general stress protein 13; Validated; Region: PRK08059 393133007695 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393133007696 RNA binding site [nucleotide binding]; other site 393133007697 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 393133007698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393133007699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133007700 homodimer interface [polypeptide binding]; other site 393133007701 catalytic residue [active] 393133007702 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 393133007703 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133007704 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133007705 Walker A/P-loop; other site 393133007706 ATP binding site [chemical binding]; other site 393133007707 Q-loop/lid; other site 393133007708 ABC transporter signature motif; other site 393133007709 Walker B; other site 393133007710 D-loop; other site 393133007711 H-loop/switch region; other site 393133007712 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133007713 active site 393133007714 P-loop; other site 393133007715 phosphorylation site [posttranslational modification] 393133007716 aspartate kinase; Reviewed; Region: PRK09034 393133007717 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 393133007718 putative catalytic residues [active] 393133007719 putative nucleotide binding site [chemical binding]; other site 393133007720 putative aspartate binding site [chemical binding]; other site 393133007721 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 393133007722 allosteric regulatory residue; other site 393133007723 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 393133007724 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 393133007725 active site 393133007726 drug efflux system protein MdtG; Provisional; Region: PRK09874 393133007727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133007728 putative substrate translocation pore; other site 393133007729 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 393133007730 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393133007731 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 393133007732 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 393133007733 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 393133007734 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 393133007735 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393133007736 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 393133007737 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 393133007738 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 393133007739 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 393133007740 CoenzymeA binding site [chemical binding]; other site 393133007741 subunit interaction site [polypeptide binding]; other site 393133007742 PHB binding site; other site 393133007743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 393133007744 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 393133007745 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 393133007746 Cl- selectivity filter; other site 393133007747 Cl- binding residues [ion binding]; other site 393133007748 pore gating glutamate residue; other site 393133007749 dimer interface [polypeptide binding]; other site 393133007750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 393133007751 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 393133007752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133007753 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 393133007754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133007755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133007756 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 393133007757 NADH(P)-binding; Region: NAD_binding_10; pfam13460 393133007758 NAD(P) binding site [chemical binding]; other site 393133007759 putative active site [active] 393133007760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 393133007761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 393133007762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133007763 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007764 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007765 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007766 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007767 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007768 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133007769 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 393133007770 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 393133007771 tetramer interfaces [polypeptide binding]; other site 393133007772 binuclear metal-binding site [ion binding]; other site 393133007773 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393133007774 Domain of unknown function DUF21; Region: DUF21; pfam01595 393133007775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393133007776 Transporter associated domain; Region: CorC_HlyC; smart01091 393133007777 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393133007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133007779 Coenzyme A binding pocket [chemical binding]; other site 393133007780 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 393133007781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007782 active site 393133007783 motif I; other site 393133007784 motif II; other site 393133007785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133007786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 393133007787 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 393133007788 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 393133007789 active site 393133007790 metal binding site [ion binding]; metal-binding site 393133007791 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 393133007792 Predicted permeases [General function prediction only]; Region: COG0730 393133007793 Predicted membrane protein [Function unknown]; Region: COG4272 393133007794 Uncharacterized conserved protein [Function unknown]; Region: COG1801 393133007795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133007796 non-specific DNA binding site [nucleotide binding]; other site 393133007797 salt bridge; other site 393133007798 sequence-specific DNA binding site [nucleotide binding]; other site 393133007799 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 393133007800 FeS assembly protein SufB; Region: sufB; TIGR01980 393133007801 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 393133007802 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 393133007803 trimerization site [polypeptide binding]; other site 393133007804 active site 393133007805 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 393133007806 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 393133007807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393133007808 catalytic residue [active] 393133007809 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 393133007810 FeS assembly protein SufD; Region: sufD; TIGR01981 393133007811 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 393133007812 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 393133007813 Walker A/P-loop; other site 393133007814 ATP binding site [chemical binding]; other site 393133007815 Q-loop/lid; other site 393133007816 ABC transporter signature motif; other site 393133007817 Walker B; other site 393133007818 D-loop; other site 393133007819 H-loop/switch region; other site 393133007820 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 393133007821 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 393133007822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133007823 ABC-ATPase subunit interface; other site 393133007824 putative PBP binding loops; other site 393133007825 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 393133007826 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 393133007827 Walker A/P-loop; other site 393133007828 ATP binding site [chemical binding]; other site 393133007829 Q-loop/lid; other site 393133007830 ABC transporter signature motif; other site 393133007831 Walker B; other site 393133007832 D-loop; other site 393133007833 H-loop/switch region; other site 393133007834 NIL domain; Region: NIL; pfam09383 393133007835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133007836 dimer interface [polypeptide binding]; other site 393133007837 phosphorylation site [posttranslational modification] 393133007838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133007839 ATP binding site [chemical binding]; other site 393133007840 Mg2+ binding site [ion binding]; other site 393133007841 G-X-G motif; other site 393133007842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133007843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133007844 active site 393133007845 phosphorylation site [posttranslational modification] 393133007846 intermolecular recognition site; other site 393133007847 dimerization interface [polypeptide binding]; other site 393133007848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133007849 DNA binding site [nucleotide binding] 393133007850 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393133007851 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 393133007852 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133007853 catalytic residues [active] 393133007854 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 393133007855 lipoyl attachment site [posttranslational modification]; other site 393133007856 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 393133007857 ArsC family; Region: ArsC; pfam03960 393133007858 putative ArsC-like catalytic residues; other site 393133007859 putative TRX-like catalytic residues [active] 393133007860 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 393133007861 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 393133007862 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393133007863 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393133007864 Walker A/P-loop; other site 393133007865 ATP binding site [chemical binding]; other site 393133007866 Q-loop/lid; other site 393133007867 ABC transporter signature motif; other site 393133007868 Walker B; other site 393133007869 D-loop; other site 393133007870 H-loop/switch region; other site 393133007871 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393133007872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393133007873 ABC-ATPase subunit interface; other site 393133007874 dimer interface [polypeptide binding]; other site 393133007875 putative PBP binding regions; other site 393133007876 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 393133007877 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 393133007878 intersubunit interface [polypeptide binding]; other site 393133007879 Predicted esterase [General function prediction only]; Region: COG0627 393133007880 S-formylglutathione hydrolase; Region: PLN02442 393133007881 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393133007882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133007883 catalytic residue [active] 393133007884 SdpI/YhfL protein family; Region: SdpI; pfam13630 393133007885 CAT RNA binding domain; Region: CAT_RBD; smart01061 393133007886 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393133007887 PRD domain; Region: PRD; pfam00874 393133007888 PRD domain; Region: PRD; pfam00874 393133007889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 393133007890 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 393133007891 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 393133007892 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 393133007893 Predicted transcriptional regulator [Transcription]; Region: COG2378 393133007894 HTH domain; Region: HTH_11; pfam08279 393133007895 WYL domain; Region: WYL; pfam13280 393133007896 Uncharacterized conserved protein [Function unknown]; Region: COG1434 393133007897 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 393133007898 putative active site [active] 393133007899 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393133007900 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 393133007901 active site 393133007902 catalytic site [active] 393133007903 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393133007904 putative metal binding site [ion binding]; other site 393133007905 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393133007906 putative metal binding site [ion binding]; other site 393133007907 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133007908 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393133007909 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393133007910 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 393133007911 active site 393133007912 catalytic site [active] 393133007913 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393133007914 putative metal binding site [ion binding]; other site 393133007915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133007916 non-specific DNA binding site [nucleotide binding]; other site 393133007917 salt bridge; other site 393133007918 sequence-specific DNA binding site [nucleotide binding]; other site 393133007919 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393133007920 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 393133007921 SmpB-tmRNA interface; other site 393133007922 ribonuclease R; Region: RNase_R; TIGR02063 393133007923 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 393133007924 RNB domain; Region: RNB; pfam00773 393133007925 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 393133007926 RNA binding site [nucleotide binding]; other site 393133007927 Esterase/lipase [General function prediction only]; Region: COG1647 393133007928 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133007929 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 393133007930 Preprotein translocase SecG subunit; Region: SecG; cl09123 393133007931 Esterase/lipase [General function prediction only]; Region: COG1647 393133007932 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393133007933 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 393133007934 PGAP1-like protein; Region: PGAP1; pfam07819 393133007935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 393133007936 enolase; Provisional; Region: eno; PRK00077 393133007937 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 393133007938 dimer interface [polypeptide binding]; other site 393133007939 metal binding site [ion binding]; metal-binding site 393133007940 substrate binding pocket [chemical binding]; other site 393133007941 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 393133007942 phosphoglyceromutase; Provisional; Region: PRK05434 393133007943 triosephosphate isomerase; Provisional; Region: PRK14567 393133007944 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 393133007945 substrate binding site [chemical binding]; other site 393133007946 dimer interface [polypeptide binding]; other site 393133007947 catalytic triad [active] 393133007948 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 393133007949 Phosphoglycerate kinase; Region: PGK; pfam00162 393133007950 substrate binding site [chemical binding]; other site 393133007951 hinge regions; other site 393133007952 ADP binding site [chemical binding]; other site 393133007953 catalytic site [active] 393133007954 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 393133007955 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 393133007956 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 393133007957 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393133007958 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393133007959 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 393133007960 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 393133007961 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 393133007962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133007963 DNA binding site [nucleotide binding] 393133007964 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 393133007965 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 393133007966 active site 393133007967 dimer interface [polypeptide binding]; other site 393133007968 MMPL family; Region: MMPL; pfam03176 393133007969 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 393133007970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133007971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133007972 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 393133007973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 393133007974 Chitin binding domain; Region: Chitin_bind_3; pfam03067 393133007975 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 393133007976 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 393133007977 Interdomain contacts; other site 393133007978 Cytokine receptor motif; other site 393133007979 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393133007980 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393133007981 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393133007982 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393133007983 Clp protease; Region: CLP_protease; pfam00574 393133007984 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 393133007985 oligomer interface [polypeptide binding]; other site 393133007986 active site residues [active] 393133007987 amino acid transporter; Region: 2A0306; TIGR00909 393133007988 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 393133007989 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393133007990 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133007991 Substrate binding site [chemical binding]; other site 393133007992 Leucine rich repeat; Region: LRR_8; pfam13855 393133007993 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133007994 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 393133007995 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 393133007996 active site 393133007997 FMN binding site [chemical binding]; other site 393133007998 substrate binding site [chemical binding]; other site 393133007999 homotetramer interface [polypeptide binding]; other site 393133008000 catalytic residue [active] 393133008001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 393133008002 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 393133008003 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 393133008004 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 393133008005 phosphate binding site [ion binding]; other site 393133008006 putative substrate binding pocket [chemical binding]; other site 393133008007 dimer interface [polypeptide binding]; other site 393133008008 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 393133008009 AAA domain; Region: AAA_18; pfam13238 393133008010 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 393133008011 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 393133008012 active site 393133008013 substrate binding site [chemical binding]; other site 393133008014 metal binding site [ion binding]; metal-binding site 393133008015 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 393133008016 active site 393133008017 catalytic residues [active] 393133008018 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 393133008019 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 393133008020 NAD binding site [chemical binding]; other site 393133008021 homodimer interface [polypeptide binding]; other site 393133008022 active site 393133008023 substrate binding site [chemical binding]; other site 393133008024 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 393133008025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393133008026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133008027 TPR repeat; Region: TPR_11; pfam13414 393133008028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133008029 binding surface 393133008030 TPR motif; other site 393133008031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 393133008032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393133008033 binding surface 393133008034 TPR motif; other site 393133008035 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 393133008036 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393133008037 putative trimer interface [polypeptide binding]; other site 393133008038 putative CoA binding site [chemical binding]; other site 393133008039 pyrophosphatase PpaX; Provisional; Region: PRK13288 393133008040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393133008041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133008042 motif II; other site 393133008043 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 393133008044 HPr kinase/phosphorylase; Provisional; Region: PRK05428 393133008045 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 393133008046 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 393133008047 Hpr binding site; other site 393133008048 active site 393133008049 homohexamer subunit interaction site [polypeptide binding]; other site 393133008050 Predicted membrane protein [Function unknown]; Region: COG1950 393133008051 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 393133008052 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 393133008053 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393133008054 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133008055 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393133008056 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393133008057 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 393133008058 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393133008059 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393133008060 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 393133008061 excinuclease ABC subunit B; Provisional; Region: PRK05298 393133008062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133008063 ATP binding site [chemical binding]; other site 393133008064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133008065 nucleotide binding region [chemical binding]; other site 393133008066 ATP-binding site [chemical binding]; other site 393133008067 Ultra-violet resistance protein B; Region: UvrB; pfam12344 393133008068 UvrB/uvrC motif; Region: UVR; pfam02151 393133008069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 393133008070 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 393133008071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393133008072 dimerization interface [polypeptide binding]; other site 393133008073 putative DNA binding site [nucleotide binding]; other site 393133008074 putative Zn2+ binding site [ion binding]; other site 393133008075 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 393133008076 PhoU domain; Region: PhoU; pfam01895 393133008077 PhoU domain; Region: PhoU; pfam01895 393133008078 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 393133008079 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 393133008080 Walker A/P-loop; other site 393133008081 ATP binding site [chemical binding]; other site 393133008082 Q-loop/lid; other site 393133008083 ABC transporter signature motif; other site 393133008084 Walker B; other site 393133008085 D-loop; other site 393133008086 H-loop/switch region; other site 393133008087 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 393133008088 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 393133008089 Walker A/P-loop; other site 393133008090 ATP binding site [chemical binding]; other site 393133008091 Q-loop/lid; other site 393133008092 ABC transporter signature motif; other site 393133008093 Walker B; other site 393133008094 D-loop; other site 393133008095 H-loop/switch region; other site 393133008096 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 393133008097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133008098 dimer interface [polypeptide binding]; other site 393133008099 conserved gate region; other site 393133008100 putative PBP binding loops; other site 393133008101 ABC-ATPase subunit interface; other site 393133008102 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 393133008103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133008104 dimer interface [polypeptide binding]; other site 393133008105 conserved gate region; other site 393133008106 putative PBP binding loops; other site 393133008107 ABC-ATPase subunit interface; other site 393133008108 PBP superfamily domain; Region: PBP_like_2; cl17296 393133008109 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 393133008110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 393133008111 HAMP domain; Region: HAMP; pfam00672 393133008112 dimerization interface [polypeptide binding]; other site 393133008113 PAS domain; Region: PAS; smart00091 393133008114 putative active site [active] 393133008115 heme pocket [chemical binding]; other site 393133008116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133008117 dimer interface [polypeptide binding]; other site 393133008118 phosphorylation site [posttranslational modification] 393133008119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133008120 ATP binding site [chemical binding]; other site 393133008121 Mg2+ binding site [ion binding]; other site 393133008122 G-X-G motif; other site 393133008123 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133008124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133008125 active site 393133008126 phosphorylation site [posttranslational modification] 393133008127 intermolecular recognition site; other site 393133008128 dimerization interface [polypeptide binding]; other site 393133008129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133008130 DNA binding site [nucleotide binding] 393133008131 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 393133008132 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 393133008133 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 393133008134 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 393133008135 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 393133008136 putative active site [active] 393133008137 catalytic site [active] 393133008138 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 393133008139 putative active site [active] 393133008140 catalytic site [active] 393133008141 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 393133008142 Peptidase family M23; Region: Peptidase_M23; pfam01551 393133008143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 393133008144 NlpC/P60 family; Region: NLPC_P60; pfam00877 393133008145 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 393133008146 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 393133008147 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 393133008148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133008149 Walker A/P-loop; other site 393133008150 ATP binding site [chemical binding]; other site 393133008151 Q-loop/lid; other site 393133008152 ABC transporter signature motif; other site 393133008153 Walker B; other site 393133008154 D-loop; other site 393133008155 H-loop/switch region; other site 393133008156 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393133008157 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133008158 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393133008159 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393133008160 peptide chain release factor 2; Validated; Region: prfB; PRK00578 393133008161 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393133008162 RF-1 domain; Region: RF-1; pfam00472 393133008163 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 393133008164 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 393133008165 nucleotide binding region [chemical binding]; other site 393133008166 helicase superfamily c-terminal domain; Region: HELICc; smart00490 393133008167 ATP-binding site [chemical binding]; other site 393133008168 SEC-C motif; Region: SEC-C; pfam02810 393133008169 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 393133008170 30S subunit binding site; other site 393133008171 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 393133008172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133008173 active site 393133008174 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 393133008175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133008176 ATP binding site [chemical binding]; other site 393133008177 putative Mg++ binding site [ion binding]; other site 393133008178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133008179 nucleotide binding region [chemical binding]; other site 393133008180 ATP-binding site [chemical binding]; other site 393133008181 EDD domain protein, DegV family; Region: DegV; TIGR00762 393133008182 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393133008183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 393133008184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133008185 active site 393133008186 phosphorylation site [posttranslational modification] 393133008187 intermolecular recognition site; other site 393133008188 dimerization interface [polypeptide binding]; other site 393133008189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 393133008190 DNA binding residues [nucleotide binding] 393133008191 dimerization interface [polypeptide binding]; other site 393133008192 Uncharacterized conserved protein [Function unknown]; Region: COG1739 393133008193 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 393133008194 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 393133008195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393133008196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393133008197 Transcriptional regulator [Transcription]; Region: LytR; COG1316 393133008198 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 393133008199 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 393133008200 Mg++ binding site [ion binding]; other site 393133008201 putative catalytic motif [active] 393133008202 substrate binding site [chemical binding]; other site 393133008203 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 393133008204 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 393133008205 active site 393133008206 octamer interface [polypeptide binding]; other site 393133008207 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 393133008208 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 393133008209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008210 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 393133008212 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 393133008213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 393133008214 dimer interface [polypeptide binding]; other site 393133008215 ssDNA binding site [nucleotide binding]; other site 393133008216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393133008217 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 393133008218 rod shape-determining protein Mbl; Provisional; Region: PRK13928 393133008219 MreB and similar proteins; Region: MreB_like; cd10225 393133008220 nucleotide binding site [chemical binding]; other site 393133008221 Mg binding site [ion binding]; other site 393133008222 putative protofilament interaction site [polypeptide binding]; other site 393133008223 RodZ interaction site [polypeptide binding]; other site 393133008224 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 393133008225 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 393133008226 hinge; other site 393133008227 active site 393133008228 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 393133008229 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 393133008230 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 393133008231 gamma subunit interface [polypeptide binding]; other site 393133008232 epsilon subunit interface [polypeptide binding]; other site 393133008233 LBP interface [polypeptide binding]; other site 393133008234 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 393133008235 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393133008236 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 393133008237 alpha subunit interaction interface [polypeptide binding]; other site 393133008238 Walker A motif; other site 393133008239 ATP binding site [chemical binding]; other site 393133008240 Walker B motif; other site 393133008241 inhibitor binding site; inhibition site 393133008242 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393133008243 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 393133008244 core domain interface [polypeptide binding]; other site 393133008245 delta subunit interface [polypeptide binding]; other site 393133008246 epsilon subunit interface [polypeptide binding]; other site 393133008247 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 393133008248 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393133008249 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 393133008250 beta subunit interaction interface [polypeptide binding]; other site 393133008251 Walker A motif; other site 393133008252 ATP binding site [chemical binding]; other site 393133008253 Walker B motif; other site 393133008254 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393133008255 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 393133008256 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 393133008257 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 393133008258 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 393133008259 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 393133008260 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 393133008261 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 393133008262 ATP synthase I chain; Region: ATP_synt_I; pfam03899 393133008263 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 393133008264 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 393133008265 active site 393133008266 homodimer interface [polypeptide binding]; other site 393133008267 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393133008268 active site 393133008269 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 393133008270 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 393133008271 dimer interface [polypeptide binding]; other site 393133008272 active site 393133008273 glycine-pyridoxal phosphate binding site [chemical binding]; other site 393133008274 folate binding site [chemical binding]; other site 393133008275 Low molecular weight phosphatase family; Region: LMWPc; cd00115 393133008276 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393133008277 active site 393133008278 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 393133008279 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 393133008280 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 393133008281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133008282 S-adenosylmethionine binding site [chemical binding]; other site 393133008283 peptide chain release factor 1; Validated; Region: prfA; PRK00591 393133008284 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393133008285 RF-1 domain; Region: RF-1; pfam00472 393133008286 thymidine kinase; Provisional; Region: PRK04296 393133008287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393133008288 ATP binding site [chemical binding]; other site 393133008289 Walker A motif; other site 393133008290 Walker B motif; other site 393133008291 homoserine kinase; Provisional; Region: PRK01212 393133008292 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393133008293 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393133008294 threonine synthase; Reviewed; Region: PRK06721 393133008295 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 393133008296 homodimer interface [polypeptide binding]; other site 393133008297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133008298 catalytic residue [active] 393133008299 homoserine dehydrogenase; Provisional; Region: PRK06349 393133008300 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 393133008301 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 393133008302 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 393133008303 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 393133008304 Predicted membrane protein [Function unknown]; Region: COG2246 393133008305 GtrA-like protein; Region: GtrA; pfam04138 393133008306 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393133008307 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393133008308 Ligand binding site; other site 393133008309 Putative Catalytic site; other site 393133008310 DXD motif; other site 393133008311 transcription termination factor Rho; Provisional; Region: rho; PRK09376 393133008312 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 393133008313 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393133008314 RNA binding site [nucleotide binding]; other site 393133008315 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 393133008316 multimer interface [polypeptide binding]; other site 393133008317 Walker A motif; other site 393133008318 ATP binding site [chemical binding]; other site 393133008319 Walker B motif; other site 393133008320 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 393133008321 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 393133008322 hinge; other site 393133008323 active site 393133008324 Predicted integral membrane protein [Function unknown]; Region: COG0392 393133008325 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393133008326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 393133008327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393133008328 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 393133008329 putative ADP-binding pocket [chemical binding]; other site 393133008330 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 393133008331 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393133008332 intersubunit interface [polypeptide binding]; other site 393133008333 active site 393133008334 zinc binding site [ion binding]; other site 393133008335 Na+ binding site [ion binding]; other site 393133008336 putative lipid kinase; Reviewed; Region: PRK13055 393133008337 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393133008338 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 393133008339 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 393133008340 amidase catalytic site [active] 393133008341 Zn binding residues [ion binding]; other site 393133008342 substrate binding site [chemical binding]; other site 393133008343 SH3-like domain; Region: SH3_8; pfam13457 393133008344 SH3-like domain; Region: SH3_8; pfam13457 393133008345 SH3-like domain; Region: SH3_8; pfam13457 393133008346 SH3-like domain; Region: SH3_8; pfam13457 393133008347 CTP synthetase; Validated; Region: pyrG; PRK05380 393133008348 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 393133008349 Catalytic site [active] 393133008350 active site 393133008351 UTP binding site [chemical binding]; other site 393133008352 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 393133008353 active site 393133008354 putative oxyanion hole; other site 393133008355 catalytic triad [active] 393133008356 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 393133008357 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 393133008358 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 393133008359 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 393133008360 active site 393133008361 HIGH motif; other site 393133008362 KMSK motif region; other site 393133008363 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 393133008364 tRNA binding surface [nucleotide binding]; other site 393133008365 anticodon binding site; other site 393133008366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 393133008367 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 393133008368 Peptidase family M50; Region: Peptidase_M50; pfam02163 393133008369 active site 393133008370 putative substrate binding region [chemical binding]; other site 393133008371 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 393133008372 active site 1 [active] 393133008373 dimer interface [polypeptide binding]; other site 393133008374 hexamer interface [polypeptide binding]; other site 393133008375 active site 2 [active] 393133008376 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 393133008377 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133008378 Zn2+ binding site [ion binding]; other site 393133008379 Mg2+ binding site [ion binding]; other site 393133008380 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393133008381 conserved hypothetical protein TIGR01655; Region: yxeA_fam 393133008382 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393133008383 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393133008384 peptide binding site [polypeptide binding]; other site 393133008385 Predicted integral membrane protein [Function unknown]; Region: COG5658 393133008386 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 393133008387 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 393133008388 catalytic triad [active] 393133008389 metal binding site [ion binding]; metal-binding site 393133008390 conserved cis-peptide bond; other site 393133008391 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 393133008392 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 393133008393 folate binding site [chemical binding]; other site 393133008394 NADP+ binding site [chemical binding]; other site 393133008395 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 393133008396 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 393133008397 putative NAD(P) binding site [chemical binding]; other site 393133008398 dimer interface [polypeptide binding]; other site 393133008399 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 393133008400 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393133008401 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393133008402 Collagen binding domain; Region: Collagen_bind; pfam05737 393133008403 Collagen binding domain; Region: Collagen_bind; pfam05737 393133008404 Collagen binding domain; Region: Collagen_bind; pfam05737 393133008405 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008406 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008407 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008408 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008409 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008410 Cna protein B-type domain; Region: Cna_B; pfam05738 393133008411 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133008412 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133008413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133008414 active site 393133008415 motif I; other site 393133008416 motif II; other site 393133008417 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 393133008418 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393133008419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393133008420 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393133008421 Walker A/P-loop; other site 393133008422 ATP binding site [chemical binding]; other site 393133008423 Q-loop/lid; other site 393133008424 ABC transporter signature motif; other site 393133008425 Walker B; other site 393133008426 D-loop; other site 393133008427 H-loop/switch region; other site 393133008428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393133008429 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393133008430 FtsX-like permease family; Region: FtsX; pfam02687 393133008431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393133008432 dimerization interface [polypeptide binding]; other site 393133008433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133008434 dimer interface [polypeptide binding]; other site 393133008435 phosphorylation site [posttranslational modification] 393133008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133008437 ATP binding site [chemical binding]; other site 393133008438 Mg2+ binding site [ion binding]; other site 393133008439 G-X-G motif; other site 393133008440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133008441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133008442 active site 393133008443 phosphorylation site [posttranslational modification] 393133008444 intermolecular recognition site; other site 393133008445 dimerization interface [polypeptide binding]; other site 393133008446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133008447 DNA binding site [nucleotide binding] 393133008448 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 393133008449 Uncharacterized conserved protein [Function unknown]; Region: COG2427 393133008450 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 393133008451 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 393133008452 catalytic loop [active] 393133008453 iron binding site [ion binding]; other site 393133008454 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 393133008455 4Fe-4S binding domain; Region: Fer4; pfam00037 393133008456 4Fe-4S binding domain; Region: Fer4; pfam00037 393133008457 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 393133008458 [4Fe-4S] binding site [ion binding]; other site 393133008459 molybdopterin cofactor binding site; other site 393133008460 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 393133008461 molybdopterin cofactor binding site; other site 393133008462 Uncharacterized conserved protein [Function unknown]; Region: COG1912 393133008463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133008464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133008465 putative substrate translocation pore; other site 393133008466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133008467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133008468 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 393133008469 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 393133008470 Walker A motif; other site 393133008471 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133008472 SH3-like domain; Region: SH3_8; pfam13457 393133008473 SH3-like domain; Region: SH3_8; pfam13457 393133008474 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133008475 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133008476 active site 393133008477 catalytic tetrad [active] 393133008478 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133008479 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133008480 DNA binding residues [nucleotide binding] 393133008481 putative dimer interface [polypeptide binding]; other site 393133008482 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 393133008483 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 393133008484 tetramer interface [polypeptide binding]; other site 393133008485 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 393133008486 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 393133008487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 393133008488 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 393133008489 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 393133008490 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 393133008491 23S rRNA interface [nucleotide binding]; other site 393133008492 L3 interface [polypeptide binding]; other site 393133008493 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 393133008494 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 393133008495 dimerization interface 3.5A [polypeptide binding]; other site 393133008496 active site 393133008497 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 393133008498 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 393133008499 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393133008500 Walker A/P-loop; other site 393133008501 ATP binding site [chemical binding]; other site 393133008502 Q-loop/lid; other site 393133008503 ABC transporter signature motif; other site 393133008504 Walker B; other site 393133008505 D-loop; other site 393133008506 H-loop/switch region; other site 393133008507 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 393133008508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393133008509 Walker A/P-loop; other site 393133008510 ATP binding site [chemical binding]; other site 393133008511 Q-loop/lid; other site 393133008512 ABC transporter signature motif; other site 393133008513 Walker B; other site 393133008514 D-loop; other site 393133008515 H-loop/switch region; other site 393133008516 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 393133008517 MgtC family; Region: MgtC; pfam02308 393133008518 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 393133008519 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 393133008520 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 393133008521 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 393133008522 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 393133008523 alphaNTD - beta interaction site [polypeptide binding]; other site 393133008524 alphaNTD homodimer interface [polypeptide binding]; other site 393133008525 alphaNTD - beta' interaction site [polypeptide binding]; other site 393133008526 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 393133008527 30S ribosomal protein S11; Validated; Region: PRK05309 393133008528 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 393133008529 30S ribosomal protein S13; Region: bact_S13; TIGR03631 393133008530 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 393133008531 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 393133008532 rRNA binding site [nucleotide binding]; other site 393133008533 predicted 30S ribosome binding site; other site 393133008534 adenylate kinase; Reviewed; Region: adk; PRK00279 393133008535 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 393133008536 AMP-binding site [chemical binding]; other site 393133008537 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 393133008538 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 393133008539 SecY translocase; Region: SecY; pfam00344 393133008540 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 393133008541 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 393133008542 23S rRNA binding site [nucleotide binding]; other site 393133008543 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 393133008544 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 393133008545 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 393133008546 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 393133008547 5S rRNA interface [nucleotide binding]; other site 393133008548 L27 interface [polypeptide binding]; other site 393133008549 23S rRNA interface [nucleotide binding]; other site 393133008550 L5 interface [polypeptide binding]; other site 393133008551 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 393133008552 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393133008553 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393133008554 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 393133008555 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 393133008556 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 393133008557 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 393133008558 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 393133008559 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 393133008560 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 393133008561 RNA binding site [nucleotide binding]; other site 393133008562 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 393133008563 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 393133008564 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 393133008565 23S rRNA interface [nucleotide binding]; other site 393133008566 putative translocon interaction site; other site 393133008567 signal recognition particle (SRP54) interaction site; other site 393133008568 L23 interface [polypeptide binding]; other site 393133008569 trigger factor interaction site; other site 393133008570 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 393133008571 23S rRNA interface [nucleotide binding]; other site 393133008572 5S rRNA interface [nucleotide binding]; other site 393133008573 putative antibiotic binding site [chemical binding]; other site 393133008574 L25 interface [polypeptide binding]; other site 393133008575 L27 interface [polypeptide binding]; other site 393133008576 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 393133008577 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 393133008578 G-X-X-G motif; other site 393133008579 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 393133008580 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 393133008581 putative translocon binding site; other site 393133008582 protein-rRNA interface [nucleotide binding]; other site 393133008583 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 393133008584 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 393133008585 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 393133008586 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 393133008587 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 393133008588 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 393133008589 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 393133008590 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 393133008591 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 393133008592 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 393133008593 UbiA prenyltransferase family; Region: UbiA; pfam01040 393133008594 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 393133008595 ApbE family; Region: ApbE; pfam02424 393133008596 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 393133008597 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 393133008598 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 393133008599 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 393133008600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393133008601 Predicted membrane protein [Function unknown]; Region: COG2259 393133008602 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 393133008603 trimer interface [polypeptide binding]; other site 393133008604 Predicted membrane protein [Function unknown]; Region: COG4769 393133008605 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393133008606 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393133008607 substrate binding pocket [chemical binding]; other site 393133008608 chain length determination region; other site 393133008609 substrate-Mg2+ binding site; other site 393133008610 catalytic residues [active] 393133008611 aspartate-rich region 1; other site 393133008612 active site lid residues [active] 393133008613 aspartate-rich region 2; other site 393133008614 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 393133008615 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 393133008616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 393133008617 active site 393133008618 metal binding site [ion binding]; metal-binding site 393133008619 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 393133008620 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 393133008621 hypothetical protein; Provisional; Region: PRK02947 393133008622 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133008623 putative active site [active] 393133008624 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 393133008625 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 393133008626 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 393133008627 active site 393133008628 substrate binding pocket [chemical binding]; other site 393133008629 homodimer interaction site [polypeptide binding]; other site 393133008630 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 393133008631 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 393133008632 active site 393133008633 P-loop; other site 393133008634 phosphorylation site [posttranslational modification] 393133008635 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133008636 active site 393133008637 phosphorylation site [posttranslational modification] 393133008638 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133008639 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133008640 PRD domain; Region: PRD; pfam00874 393133008641 PRD domain; Region: PRD; pfam00874 393133008642 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133008643 active site 393133008644 P-loop; other site 393133008645 phosphorylation site [posttranslational modification] 393133008646 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133008647 active site 393133008648 phosphorylation site [posttranslational modification] 393133008649 elongation factor Tu; Reviewed; Region: PRK00049 393133008650 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 393133008651 G1 box; other site 393133008652 GEF interaction site [polypeptide binding]; other site 393133008653 GTP/Mg2+ binding site [chemical binding]; other site 393133008654 Switch I region; other site 393133008655 G2 box; other site 393133008656 G3 box; other site 393133008657 Switch II region; other site 393133008658 G4 box; other site 393133008659 G5 box; other site 393133008660 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 393133008661 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 393133008662 Antibiotic Binding Site [chemical binding]; other site 393133008663 elongation factor G; Reviewed; Region: PRK00007 393133008664 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 393133008665 G1 box; other site 393133008666 putative GEF interaction site [polypeptide binding]; other site 393133008667 GTP/Mg2+ binding site [chemical binding]; other site 393133008668 Switch I region; other site 393133008669 G2 box; other site 393133008670 G3 box; other site 393133008671 Switch II region; other site 393133008672 G4 box; other site 393133008673 G5 box; other site 393133008674 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 393133008675 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 393133008676 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 393133008677 30S ribosomal protein S7; Validated; Region: PRK05302 393133008678 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 393133008679 S17 interaction site [polypeptide binding]; other site 393133008680 S8 interaction site; other site 393133008681 16S rRNA interaction site [nucleotide binding]; other site 393133008682 streptomycin interaction site [chemical binding]; other site 393133008683 23S rRNA interaction site [nucleotide binding]; other site 393133008684 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 393133008685 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 393133008686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393133008687 Zn2+ binding site [ion binding]; other site 393133008688 Mg2+ binding site [ion binding]; other site 393133008689 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 393133008690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133008691 Coenzyme A binding pocket [chemical binding]; other site 393133008692 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133008693 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133008694 substrate binding site [chemical binding]; other site 393133008695 hexamer interface [polypeptide binding]; other site 393133008696 metal binding site [ion binding]; metal-binding site 393133008697 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393133008698 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393133008699 TPP-binding site [chemical binding]; other site 393133008700 dimer interface [polypeptide binding]; other site 393133008701 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393133008702 PYR/PP interface [polypeptide binding]; other site 393133008703 dimer interface [polypeptide binding]; other site 393133008704 TPP binding site [chemical binding]; other site 393133008705 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393133008706 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393133008707 substrate binding site [chemical binding]; other site 393133008708 hexamer interface [polypeptide binding]; other site 393133008709 metal binding site [ion binding]; metal-binding site 393133008710 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393133008711 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393133008712 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 393133008713 putative NAD(P) binding site [chemical binding]; other site 393133008714 catalytic Zn binding site [ion binding]; other site 393133008715 structural Zn binding site [ion binding]; other site 393133008716 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393133008717 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 393133008718 putative NAD(P) binding site [chemical binding]; other site 393133008719 catalytic Zn binding site [ion binding]; other site 393133008720 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393133008721 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393133008722 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393133008723 active site 393133008724 P-loop; other site 393133008725 phosphorylation site [posttranslational modification] 393133008726 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133008727 active site 393133008728 phosphorylation site [posttranslational modification] 393133008729 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133008730 PRD domain; Region: PRD; pfam00874 393133008731 PRD domain; Region: PRD; pfam00874 393133008732 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133008733 active site 393133008734 P-loop; other site 393133008735 phosphorylation site [posttranslational modification] 393133008736 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133008737 active site 393133008738 phosphorylation site [posttranslational modification] 393133008739 Predicted membrane protein [Function unknown]; Region: COG4905 393133008740 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 393133008741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 393133008742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 393133008743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393133008744 active site 393133008745 Helix-turn-helix domain; Region: HTH_18; pfam12833 393133008746 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393133008747 Ligand Binding Site [chemical binding]; other site 393133008748 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 393133008749 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 393133008750 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 393133008751 active site 393133008752 DNA binding site [nucleotide binding] 393133008753 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 393133008754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393133008755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393133008756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393133008757 active site 393133008758 phosphorylation site [posttranslational modification] 393133008759 intermolecular recognition site; other site 393133008760 dimerization interface [polypeptide binding]; other site 393133008761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393133008762 DNA binding site [nucleotide binding] 393133008763 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 393133008764 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 393133008765 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 393133008766 Ligand Binding Site [chemical binding]; other site 393133008767 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 393133008768 GAF domain; Region: GAF_3; pfam13492 393133008769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393133008770 dimer interface [polypeptide binding]; other site 393133008771 phosphorylation site [posttranslational modification] 393133008772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393133008773 ATP binding site [chemical binding]; other site 393133008774 Mg2+ binding site [ion binding]; other site 393133008775 G-X-G motif; other site 393133008776 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 393133008777 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 393133008778 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133008779 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 393133008780 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133008781 active site 393133008782 P-loop; other site 393133008783 phosphorylation site [posttranslational modification] 393133008784 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133008785 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133008786 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133008787 methionine cluster; other site 393133008788 active site 393133008789 phosphorylation site [posttranslational modification] 393133008790 metal binding site [ion binding]; metal-binding site 393133008791 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393133008792 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393133008793 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 393133008794 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 393133008795 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393133008796 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393133008797 Soluble P-type ATPase [General function prediction only]; Region: COG4087 393133008798 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393133008799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133008800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133008801 autolysin; Reviewed; Region: PRK06347 393133008802 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393133008803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008805 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393133008807 Protein of unknown function (DUF970); Region: DUF970; pfam06153 393133008808 thymidylate kinase; Validated; Region: tmk; PRK00698 393133008809 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 393133008810 TMP-binding site; other site 393133008811 ATP-binding site [chemical binding]; other site 393133008812 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 393133008813 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 393133008814 homodimer interface [polypeptide binding]; other site 393133008815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133008816 catalytic residue [active] 393133008817 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 393133008818 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 393133008819 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393133008820 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393133008821 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 393133008822 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 393133008823 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133008824 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133008825 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133008826 putative active site [active] 393133008827 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393133008828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133008829 active site 393133008830 motif I; other site 393133008831 motif II; other site 393133008832 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393133008833 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393133008834 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393133008835 active site 393133008836 catalytic tetrad [active] 393133008837 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 393133008838 recombination protein RecR; Reviewed; Region: recR; PRK00076 393133008839 RecR protein; Region: RecR; pfam02132 393133008840 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 393133008841 putative active site [active] 393133008842 putative metal-binding site [ion binding]; other site 393133008843 tetramer interface [polypeptide binding]; other site 393133008844 hypothetical protein; Validated; Region: PRK00153 393133008845 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 393133008846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393133008847 Walker A motif; other site 393133008848 ATP binding site [chemical binding]; other site 393133008849 Walker B motif; other site 393133008850 arginine finger; other site 393133008851 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 393133008852 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 393133008853 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 393133008854 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133008855 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133008856 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 393133008857 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 393133008858 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 393133008859 N- and C-terminal domain interface [polypeptide binding]; other site 393133008860 active site 393133008861 catalytic site [active] 393133008862 metal binding site [ion binding]; metal-binding site 393133008863 carbohydrate binding site [chemical binding]; other site 393133008864 ATP binding site [chemical binding]; other site 393133008865 SH3-like domain; Region: SH3_8; pfam13457 393133008866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 393133008867 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 393133008868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133008869 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 393133008870 Walker A/P-loop; other site 393133008871 ATP binding site [chemical binding]; other site 393133008872 Q-loop/lid; other site 393133008873 ABC transporter signature motif; other site 393133008874 Walker B; other site 393133008875 D-loop; other site 393133008876 H-loop/switch region; other site 393133008877 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 393133008878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133008879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133008880 Walker A/P-loop; other site 393133008881 ATP binding site [chemical binding]; other site 393133008882 Q-loop/lid; other site 393133008883 ABC transporter signature motif; other site 393133008884 Walker B; other site 393133008885 D-loop; other site 393133008886 H-loop/switch region; other site 393133008887 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 393133008888 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 393133008889 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 393133008890 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 393133008891 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 393133008892 nucleoside/Zn binding site; other site 393133008893 dimer interface [polypeptide binding]; other site 393133008894 catalytic motif [active] 393133008895 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 393133008896 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 393133008897 active site 393133008898 acyl-activating enzyme (AAE) consensus motif; other site 393133008899 putative CoA binding site [chemical binding]; other site 393133008900 AMP binding site [chemical binding]; other site 393133008901 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393133008902 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393133008903 active site 393133008904 trimer interface [polypeptide binding]; other site 393133008905 allosteric site; other site 393133008906 active site lid [active] 393133008907 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393133008908 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 393133008909 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393133008910 DNA binding residues [nucleotide binding] 393133008911 drug binding residues [chemical binding]; other site 393133008912 dimer interface [polypeptide binding]; other site 393133008913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393133008914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393133008915 Coenzyme A binding pocket [chemical binding]; other site 393133008916 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393133008917 dimer interface [polypeptide binding]; other site 393133008918 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393133008919 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393133008920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393133008921 MarR family; Region: MarR; pfam01047 393133008922 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 393133008923 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 393133008924 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393133008925 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393133008926 DNA binding residues [nucleotide binding] 393133008927 putative dimer interface [polypeptide binding]; other site 393133008928 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 393133008929 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 393133008930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133008931 active site 393133008932 motif I; other site 393133008933 motif II; other site 393133008934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133008935 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133008936 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133008937 putative active site [active] 393133008938 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 393133008939 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133008940 active site 393133008941 phosphorylation site [posttranslational modification] 393133008942 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393133008943 active site 393133008944 P-loop; other site 393133008945 phosphorylation site [posttranslational modification] 393133008946 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393133008947 alpha-mannosidase; Provisional; Region: PRK09819 393133008948 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393133008949 active site 393133008950 metal binding site [ion binding]; metal-binding site 393133008951 catalytic site [active] 393133008952 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 393133008953 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 393133008954 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 393133008955 active site 393133008956 homodimer interface [polypeptide binding]; other site 393133008957 catalytic site [active] 393133008958 glycerate kinase; Region: TIGR00045 393133008959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133008960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133008961 DNA binding site [nucleotide binding] 393133008962 domain linker motif; other site 393133008963 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 393133008964 putative dimerization interface [polypeptide binding]; other site 393133008965 putative ligand binding site [chemical binding]; other site 393133008966 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393133008967 Domain of unknown function DUF21; Region: DUF21; pfam01595 393133008968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393133008969 Transporter associated domain; Region: CorC_HlyC; pfam03471 393133008970 NAD-dependent deacetylase; Provisional; Region: PRK00481 393133008971 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 393133008972 NAD+ binding site [chemical binding]; other site 393133008973 substrate binding site [chemical binding]; other site 393133008974 putative Zn binding site [ion binding]; other site 393133008975 Pathogenicity locus; Region: Cdd1; pfam11731 393133008976 drug efflux system protein MdtG; Provisional; Region: PRK09874 393133008977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133008978 putative substrate translocation pore; other site 393133008979 Src Homology 3 domain superfamily; Region: SH3; cl17036 393133008980 Variant SH3 domain; Region: SH3_2; pfam07653 393133008981 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 393133008982 active site 393133008983 intersubunit interactions; other site 393133008984 catalytic residue [active] 393133008985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393133008986 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393133008987 ligand binding site [chemical binding]; other site 393133008988 flexible hinge region; other site 393133008989 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393133008990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133008991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133008992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133008993 Walker A/P-loop; other site 393133008994 ATP binding site [chemical binding]; other site 393133008995 Q-loop/lid; other site 393133008996 ABC transporter signature motif; other site 393133008997 Walker B; other site 393133008998 D-loop; other site 393133008999 H-loop/switch region; other site 393133009000 TfoX C-terminal domain; Region: TfoX_C; pfam04994 393133009001 seryl-tRNA synthetase; Provisional; Region: PRK05431 393133009002 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 393133009003 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 393133009004 dimer interface [polypeptide binding]; other site 393133009005 active site 393133009006 motif 1; other site 393133009007 motif 2; other site 393133009008 motif 3; other site 393133009009 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 393133009010 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 393133009011 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393133009012 Glutamine amidotransferase class-I; Region: GATase; pfam00117 393133009013 glutamine binding [chemical binding]; other site 393133009014 catalytic triad [active] 393133009015 aminodeoxychorismate synthase; Provisional; Region: PRK07508 393133009016 chorismate binding enzyme; Region: Chorismate_bind; cl10555 393133009017 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 393133009018 substrate-cofactor binding pocket; other site 393133009019 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393133009020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133009021 catalytic residue [active] 393133009022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133009023 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133009024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133009025 Walker A/P-loop; other site 393133009026 ATP binding site [chemical binding]; other site 393133009027 Q-loop/lid; other site 393133009028 ABC transporter signature motif; other site 393133009029 Walker B; other site 393133009030 D-loop; other site 393133009031 H-loop/switch region; other site 393133009032 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393133009033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393133009034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393133009035 Walker A/P-loop; other site 393133009036 ATP binding site [chemical binding]; other site 393133009037 Q-loop/lid; other site 393133009038 ABC transporter signature motif; other site 393133009039 Walker B; other site 393133009040 D-loop; other site 393133009041 H-loop/switch region; other site 393133009042 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 393133009043 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 393133009044 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 393133009045 Predicted acyl esterases [General function prediction only]; Region: COG2936 393133009046 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 393133009047 DNA topoisomerase III; Provisional; Region: PRK07726 393133009048 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 393133009049 active site 393133009050 putative interdomain interaction site [polypeptide binding]; other site 393133009051 putative metal-binding site [ion binding]; other site 393133009052 putative nucleotide binding site [chemical binding]; other site 393133009053 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 393133009054 domain I; other site 393133009055 DNA binding groove [nucleotide binding] 393133009056 phosphate binding site [ion binding]; other site 393133009057 domain II; other site 393133009058 domain III; other site 393133009059 nucleotide binding site [chemical binding]; other site 393133009060 catalytic site [active] 393133009061 domain IV; other site 393133009062 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 393133009063 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 393133009064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393133009065 ATP binding site [chemical binding]; other site 393133009066 putative Mg++ binding site [ion binding]; other site 393133009067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393133009068 nucleotide binding region [chemical binding]; other site 393133009069 ATP-binding site [chemical binding]; other site 393133009070 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 393133009071 HRDC domain; Region: HRDC; pfam00570 393133009072 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 393133009073 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 393133009074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 393133009075 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 393133009076 active site 393133009077 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 393133009078 putative ADP-ribose binding site [chemical binding]; other site 393133009079 putative active site [active] 393133009080 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393133009081 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133009082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133009083 ABC transporter; Region: ABC_tran_2; pfam12848 393133009084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393133009085 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393133009086 beta-galactosidase; Region: BGL; TIGR03356 393133009087 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133009088 active site 393133009089 P-loop; other site 393133009090 phosphorylation site [posttranslational modification] 393133009091 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393133009092 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133009093 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133009094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133009095 nucleotide binding site [chemical binding]; other site 393133009096 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133009097 methionine cluster; other site 393133009098 active site 393133009099 phosphorylation site [posttranslational modification] 393133009100 metal binding site [ion binding]; metal-binding site 393133009101 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133009102 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133009103 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133009104 putative active site [active] 393133009105 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 393133009106 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393133009107 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 393133009108 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393133009109 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393133009110 Walker A/P-loop; other site 393133009111 ATP binding site [chemical binding]; other site 393133009112 Q-loop/lid; other site 393133009113 ABC transporter signature motif; other site 393133009114 Walker B; other site 393133009115 D-loop; other site 393133009116 H-loop/switch region; other site 393133009117 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 393133009118 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 393133009119 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393133009120 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 393133009121 beta-galactosidase; Region: BGL; TIGR03356 393133009122 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393133009123 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133009124 active site turn [active] 393133009125 phosphorylation site [posttranslational modification] 393133009126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133009127 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393133009128 HPr interaction site; other site 393133009129 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133009130 active site 393133009131 phosphorylation site [posttranslational modification] 393133009132 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393133009133 CAT RNA binding domain; Region: CAT_RBD; smart01061 393133009134 PRD domain; Region: PRD; pfam00874 393133009135 PRD domain; Region: PRD; pfam00874 393133009136 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393133009137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009138 putative substrate translocation pore; other site 393133009139 GTP-binding protein YchF; Reviewed; Region: PRK09601 393133009140 YchF GTPase; Region: YchF; cd01900 393133009141 G1 box; other site 393133009142 GTP/Mg2+ binding site [chemical binding]; other site 393133009143 Switch I region; other site 393133009144 G2 box; other site 393133009145 Switch II region; other site 393133009146 G3 box; other site 393133009147 G4 box; other site 393133009148 G5 box; other site 393133009149 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 393133009150 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393133009151 methionine cluster; other site 393133009152 active site 393133009153 phosphorylation site [posttranslational modification] 393133009154 metal binding site [ion binding]; metal-binding site 393133009155 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 393133009156 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 393133009157 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 393133009158 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393133009159 active site 393133009160 P-loop; other site 393133009161 phosphorylation site [posttranslational modification] 393133009162 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393133009163 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 393133009164 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393133009165 HTH domain; Region: HTH_11; pfam08279 393133009166 Mga helix-turn-helix domain; Region: Mga; pfam05043 393133009167 PRD domain; Region: PRD; pfam00874 393133009168 PRD domain; Region: PRD; pfam00874 393133009169 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393133009170 active site 393133009171 P-loop; other site 393133009172 phosphorylation site [posttranslational modification] 393133009173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133009174 active site 393133009175 phosphorylation site [posttranslational modification] 393133009176 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 393133009177 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 393133009178 tetramer interface [polypeptide binding]; other site 393133009179 heme binding pocket [chemical binding]; other site 393133009180 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 393133009181 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393133009182 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393133009183 active site turn [active] 393133009184 phosphorylation site [posttranslational modification] 393133009185 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393133009186 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 393133009187 HPr interaction site; other site 393133009188 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393133009189 active site 393133009190 phosphorylation site [posttranslational modification] 393133009191 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393133009192 CAT RNA binding domain; Region: CAT_RBD; pfam03123 393133009193 PRD domain; Region: PRD; pfam00874 393133009194 PRD domain; Region: PRD; pfam00874 393133009195 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 393133009196 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 393133009197 ParB-like nuclease domain; Region: ParB; smart00470 393133009198 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 393133009199 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 393133009200 P-loop; other site 393133009201 Magnesium ion binding site [ion binding]; other site 393133009202 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 393133009203 Magnesium ion binding site [ion binding]; other site 393133009204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393133009205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393133009206 non-specific DNA binding site [nucleotide binding]; other site 393133009207 salt bridge; other site 393133009208 sequence-specific DNA binding site [nucleotide binding]; other site 393133009209 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 393133009210 ParB-like nuclease domain; Region: ParBc; pfam02195 393133009211 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393133009212 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393133009213 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393133009214 putative active site [active] 393133009215 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393133009216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393133009217 nucleotide binding site [chemical binding]; other site 393133009218 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393133009219 active site 393133009220 phosphorylation site [posttranslational modification] 393133009221 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 393133009222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133009223 motif II; other site 393133009224 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 393133009225 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 393133009226 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 393133009227 active site 393133009228 P-loop; other site 393133009229 phosphorylation site [posttranslational modification] 393133009230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133009231 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133009232 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393133009233 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 393133009234 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 393133009235 putative active site cavity [active] 393133009236 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 393133009237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393133009238 S-adenosylmethionine binding site [chemical binding]; other site 393133009239 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 393133009240 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 393133009241 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 393133009242 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 393133009243 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 393133009244 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 393133009245 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 393133009246 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 393133009247 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 393133009248 trmE is a tRNA modification GTPase; Region: trmE; cd04164 393133009249 G1 box; other site 393133009250 GTP/Mg2+ binding site [chemical binding]; other site 393133009251 Switch I region; other site 393133009252 G2 box; other site 393133009253 Switch II region; other site 393133009254 G3 box; other site 393133009255 G4 box; other site 393133009256 G5 box; other site 393133009257 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 393133009258 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 393133009259 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 393133009260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393133009261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393133009262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 393133009263 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 393133009264 NADP binding site [chemical binding]; other site 393133009265 homodimer interface [polypeptide binding]; other site 393133009266 active site 393133009267 substrate binding site [chemical binding]; other site 393133009268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009269 D-galactonate transporter; Region: 2A0114; TIGR00893 393133009270 putative substrate translocation pore; other site 393133009271 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393133009272 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 393133009273 metal binding site [ion binding]; metal-binding site 393133009274 dimer interface [polypeptide binding]; other site 393133009275 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 393133009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 393133009277 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393133009278 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 393133009279 metal binding site [ion binding]; metal-binding site 393133009280 dimer interface [polypeptide binding]; other site 393133009281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133009282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393133009283 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 393133009284 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393133009285 Leucine-rich repeats; other site 393133009286 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133009287 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133009288 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393133009289 Substrate binding site [chemical binding]; other site 393133009290 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133009291 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133009292 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133009293 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393133009294 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393133009295 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 393133009296 Uncharacterized conserved protein [Function unknown]; Region: COG4198 393133009297 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 393133009298 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 393133009299 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 393133009300 putative ligand binding site [chemical binding]; other site 393133009301 putative NAD binding site [chemical binding]; other site 393133009302 putative catalytic site [active] 393133009303 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 393133009304 L-serine binding site [chemical binding]; other site 393133009305 ACT domain interface; other site 393133009306 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 393133009307 homodimer interface [polypeptide binding]; other site 393133009308 substrate-cofactor binding pocket; other site 393133009309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393133009310 catalytic residue [active] 393133009311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133009313 putative substrate translocation pore; other site 393133009314 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393133009315 MarR family; Region: MarR_2; pfam12802 393133009316 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 393133009317 dimer interface [polypeptide binding]; other site 393133009318 FMN binding site [chemical binding]; other site 393133009319 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393133009320 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393133009321 catalytic residues [active] 393133009322 beta-phosphoglucomutase; Region: bPGM; TIGR01990 393133009323 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393133009324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393133009325 motif II; other site 393133009326 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 393133009327 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 393133009328 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 393133009329 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 393133009330 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 393133009331 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393133009332 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393133009333 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393133009334 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393133009335 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393133009336 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 393133009337 putative NAD(P) binding site [chemical binding]; other site 393133009338 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393133009339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133009340 dimer interface [polypeptide binding]; other site 393133009341 conserved gate region; other site 393133009342 putative PBP binding loops; other site 393133009343 ABC-ATPase subunit interface; other site 393133009344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393133009345 dimer interface [polypeptide binding]; other site 393133009346 conserved gate region; other site 393133009347 putative PBP binding loops; other site 393133009348 ABC-ATPase subunit interface; other site 393133009349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393133009350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393133009351 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 393133009352 sucrose phosphorylase; Provisional; Region: PRK13840 393133009353 active site 393133009354 homodimer interface [polypeptide binding]; other site 393133009355 catalytic site [active] 393133009356 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393133009357 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393133009358 DNA binding site [nucleotide binding] 393133009359 domain linker motif; other site 393133009360 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 393133009361 putative dimerization interface [polypeptide binding]; other site 393133009362 putative ligand binding site [chemical binding]; other site 393133009363 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 393133009364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393133009365 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393133009366 Coenzyme A binding pocket [chemical binding]; other site 393133009367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133009369 putative substrate translocation pore; other site 393133009370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009371 Domain of unknown function (DUF718); Region: DUF718; cl01281 393133009372 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 393133009373 intersubunit interface [polypeptide binding]; other site 393133009374 active site 393133009375 Zn2+ binding site [ion binding]; other site 393133009376 L-rhamnose isomerase; Provisional; Region: PRK01076 393133009377 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 393133009378 N- and C-terminal domain interface [polypeptide binding]; other site 393133009379 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 393133009380 active site 393133009381 putative catalytic site [active] 393133009382 metal binding site [ion binding]; metal-binding site 393133009383 ATP binding site [chemical binding]; other site 393133009384 carbohydrate binding site [chemical binding]; other site 393133009385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393133009386 putative substrate translocation pore; other site 393133009387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393133009388 Cupin domain; Region: Cupin_2; pfam07883 393133009389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393133009390 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 393133009391 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 393133009392 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 393133009393 G-X-X-G motif; other site 393133009394 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 393133009395 RxxxH motif; other site 393133009396 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 393133009397 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 393133009398 ribonuclease P; Reviewed; Region: rnpA; PRK00499 393133009399 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399