-- dump date 20140619_132310 -- class Genbank::misc_feature -- table misc_feature_note -- id note 882095000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 882095000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 882095000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095000004 Walker A motif; other site 882095000005 ATP binding site [chemical binding]; other site 882095000006 Walker B motif; other site 882095000007 arginine finger; other site 882095000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 882095000009 DnaA box-binding interface [nucleotide binding]; other site 882095000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 882095000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 882095000012 putative DNA binding surface [nucleotide binding]; other site 882095000013 dimer interface [polypeptide binding]; other site 882095000014 beta-clamp/clamp loader binding surface; other site 882095000015 beta-clamp/translesion DNA polymerase binding surface; other site 882095000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882095000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 882095000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 882095000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 882095000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 882095000021 Walker A/P-loop; other site 882095000022 ATP binding site [chemical binding]; other site 882095000023 Q-loop/lid; other site 882095000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095000025 ABC transporter signature motif; other site 882095000026 Walker B; other site 882095000027 D-loop; other site 882095000028 H-loop/switch region; other site 882095000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 882095000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095000031 Mg2+ binding site [ion binding]; other site 882095000032 G-X-G motif; other site 882095000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882095000034 anchoring element; other site 882095000035 dimer interface [polypeptide binding]; other site 882095000036 ATP binding site [chemical binding]; other site 882095000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882095000038 active site 882095000039 putative metal-binding site [ion binding]; other site 882095000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882095000041 DNA gyrase subunit A; Validated; Region: PRK05560 882095000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882095000043 CAP-like domain; other site 882095000044 active site 882095000045 primary dimer interface [polypeptide binding]; other site 882095000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095000051 cardiolipin synthetase; Reviewed; Region: PRK12452 882095000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882095000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882095000054 putative active site [active] 882095000055 catalytic site [active] 882095000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882095000057 putative active site [active] 882095000058 catalytic site [active] 882095000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882095000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095000061 Coenzyme A binding pocket [chemical binding]; other site 882095000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 882095000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882095000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882095000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 882095000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882095000067 SH3-like domain; Region: SH3_8; pfam13457 882095000068 SH3-like domain; Region: SH3_8; pfam13457 882095000069 SH3-like domain; Region: SH3_8; pfam13457 882095000070 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 882095000071 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 882095000072 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 882095000073 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 882095000074 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 882095000075 D-pathway; other site 882095000076 Putative ubiquinol binding site [chemical binding]; other site 882095000077 Low-spin heme (heme b) binding site [chemical binding]; other site 882095000078 Putative water exit pathway; other site 882095000079 Binuclear center (heme o3/CuB) [ion binding]; other site 882095000080 K-pathway; other site 882095000081 Putative proton exit pathway; other site 882095000082 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 882095000083 Subunit I/III interface [polypeptide binding]; other site 882095000084 Subunit III/IV interface [polypeptide binding]; other site 882095000085 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 882095000086 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882095000087 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 882095000088 putative active site [active] 882095000089 putative metal binding site [ion binding]; other site 882095000090 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882095000091 beta-galactosidase; Region: BGL; TIGR03356 882095000092 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882095000093 Bacterial SH3 domain; Region: SH3_3; pfam08239 882095000094 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882095000095 putative active site [active] 882095000096 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095000097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095000098 DNA-binding site [nucleotide binding]; DNA binding site 882095000099 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882095000100 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095000101 active site 882095000102 active pocket/dimerization site; other site 882095000103 phosphorylation site [posttranslational modification] 882095000104 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882095000105 active site 882095000106 phosphorylation site [posttranslational modification] 882095000107 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 882095000108 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 882095000109 hypothetical protein; Provisional; Region: PRK02947 882095000110 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095000111 putative active site [active] 882095000112 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882095000113 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 882095000114 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882095000115 active site turn [active] 882095000116 phosphorylation site [posttranslational modification] 882095000117 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882095000118 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882095000119 HPr interaction site; other site 882095000120 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882095000121 active site 882095000122 phosphorylation site [posttranslational modification] 882095000123 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882095000124 putative dimer interface [polypeptide binding]; other site 882095000125 catalytic triad [active] 882095000126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095000127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095000128 Walker A/P-loop; other site 882095000129 ATP binding site [chemical binding]; other site 882095000130 Q-loop/lid; other site 882095000131 ABC transporter signature motif; other site 882095000132 Walker B; other site 882095000133 D-loop; other site 882095000134 H-loop/switch region; other site 882095000135 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 882095000136 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 882095000137 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095000138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000139 active site 882095000140 motif I; other site 882095000141 motif II; other site 882095000142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095000144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095000145 DNA binding site [nucleotide binding] 882095000146 domain linker motif; other site 882095000147 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 882095000148 dimerization interface [polypeptide binding]; other site 882095000149 putative ligand binding site [chemical binding]; other site 882095000150 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095000151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095000152 nucleotide binding site [chemical binding]; other site 882095000153 Butyrate kinase [Energy production and conversion]; Region: COG3426 882095000154 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 882095000155 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 882095000156 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095000157 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095000158 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882095000159 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882095000160 dimer interface [polypeptide binding]; other site 882095000161 active site 882095000162 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882095000163 dimer interface [polypeptide binding]; other site 882095000164 active site 882095000165 putrescine carbamoyltransferase; Provisional; Region: PRK02255 882095000166 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882095000167 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882095000168 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 882095000169 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 882095000170 agmatine deiminase; Provisional; Region: PRK13551 882095000171 agmatine deiminase; Region: agmatine_aguA; TIGR03380 882095000172 carbamate kinase; Reviewed; Region: PRK12686 882095000173 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 882095000174 putative substrate binding site [chemical binding]; other site 882095000175 nucleotide binding site [chemical binding]; other site 882095000176 nucleotide binding site [chemical binding]; other site 882095000177 homodimer interface [polypeptide binding]; other site 882095000178 agmatine deiminase; Provisional; Region: PRK13551 882095000179 agmatine deiminase; Region: agmatine_aguA; TIGR03380 882095000180 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095000181 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095000182 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095000183 putative active site [active] 882095000184 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 882095000185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882095000186 arginine deiminase; Provisional; Region: PRK01388 882095000187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 882095000188 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882095000189 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882095000190 dimer interface [polypeptide binding]; other site 882095000191 ssDNA binding site [nucleotide binding]; other site 882095000192 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095000193 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 882095000194 Predicted membrane protein [Function unknown]; Region: COG3212 882095000195 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882095000196 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882095000197 putative accessory gene regulator protein; Provisional; Region: PRK01100 882095000198 Staphylococcal AgrD protein; Region: AgrD; cl05477 882095000199 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882095000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095000201 ATP binding site [chemical binding]; other site 882095000202 Mg2+ binding site [ion binding]; other site 882095000203 G-X-G motif; other site 882095000204 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882095000205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095000206 active site 882095000207 phosphorylation site [posttranslational modification] 882095000208 intermolecular recognition site; other site 882095000209 LytTr DNA-binding domain; Region: LytTR; pfam04397 882095000210 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 882095000211 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 882095000212 DHH family; Region: DHH; pfam01368 882095000213 DHHA1 domain; Region: DHHA1; pfam02272 882095000214 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 882095000215 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 882095000216 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 882095000217 replicative DNA helicase; Provisional; Region: PRK05748 882095000218 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 882095000219 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 882095000220 Walker A motif; other site 882095000221 ATP binding site [chemical binding]; other site 882095000222 Walker B motif; other site 882095000223 DNA binding loops [nucleotide binding] 882095000224 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 882095000225 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 882095000226 GDP-binding site [chemical binding]; other site 882095000227 ACT binding site; other site 882095000228 IMP binding site; other site 882095000229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 882095000230 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882095000231 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 882095000232 Predicted membrane protein [Function unknown]; Region: COG1511 882095000233 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 882095000234 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 882095000235 Uncharacterized small protein [Function unknown]; Region: COG5417 882095000236 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 882095000237 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 882095000238 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 882095000239 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 882095000240 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882095000241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882095000242 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 882095000243 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 882095000244 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 882095000245 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 882095000246 tetramer interface [polypeptide binding]; other site 882095000247 active site 882095000248 Mg2+/Mn2+ binding site [ion binding]; other site 882095000249 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882095000250 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882095000251 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882095000252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882095000253 DNA binding site [nucleotide binding] 882095000254 active site 882095000255 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882095000256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 882095000257 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882095000258 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 882095000259 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 882095000260 putative ligand binding site [chemical binding]; other site 882095000261 putative NAD binding site [chemical binding]; other site 882095000262 catalytic site [active] 882095000263 LXG domain of WXG superfamily; Region: LXG; pfam04740 882095000264 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095000265 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095000266 DNA binding residues [nucleotide binding] 882095000267 putative dimer interface [polypeptide binding]; other site 882095000268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095000269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095000270 active site 882095000271 catalytic tetrad [active] 882095000272 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000273 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095000274 ATP synthase subunit C; Region: ATP-synt_C; cl00466 882095000275 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882095000276 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 882095000277 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882095000278 Walker A motif; other site 882095000279 ATP binding site [chemical binding]; other site 882095000280 Walker B motif; other site 882095000281 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882095000282 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882095000283 core domain interface [polypeptide binding]; other site 882095000284 delta subunit interface [polypeptide binding]; other site 882095000285 epsilon subunit interface [polypeptide binding]; other site 882095000286 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 882095000287 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882095000288 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882095000289 alpha subunit interaction interface [polypeptide binding]; other site 882095000290 Walker A motif; other site 882095000291 ATP binding site [chemical binding]; other site 882095000292 Walker B motif; other site 882095000293 inhibitor binding site; inhibition site 882095000294 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882095000295 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 882095000296 gamma subunit interface [polypeptide binding]; other site 882095000297 epsilon subunit interface [polypeptide binding]; other site 882095000298 LBP interface [polypeptide binding]; other site 882095000299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000300 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 882095000301 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095000302 active pocket/dimerization site; other site 882095000303 active site 882095000304 phosphorylation site [posttranslational modification] 882095000305 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882095000306 active site 882095000307 phosphorylation site [posttranslational modification] 882095000308 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882095000309 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882095000310 Domain of unknown function (DUF956); Region: DUF956; pfam06115 882095000311 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 882095000312 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882095000313 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882095000314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095000315 dimerization interface [polypeptide binding]; other site 882095000316 putative DNA binding site [nucleotide binding]; other site 882095000317 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882095000318 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 882095000319 dimer interface [polypeptide binding]; other site 882095000320 FMN binding site [chemical binding]; other site 882095000321 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 882095000322 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 882095000323 active site 882095000324 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882095000325 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882095000326 Interdomain contacts; other site 882095000327 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882095000328 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882095000329 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095000330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095000331 nucleotide binding site [chemical binding]; other site 882095000332 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882095000333 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882095000334 Walker A/P-loop; other site 882095000335 ATP binding site [chemical binding]; other site 882095000336 Q-loop/lid; other site 882095000337 ABC transporter signature motif; other site 882095000338 Walker B; other site 882095000339 D-loop; other site 882095000340 H-loop/switch region; other site 882095000341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095000342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095000343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095000344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095000345 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882095000346 Walker A/P-loop; other site 882095000347 ATP binding site [chemical binding]; other site 882095000348 Q-loop/lid; other site 882095000349 ABC transporter signature motif; other site 882095000350 Walker B; other site 882095000351 D-loop; other site 882095000352 H-loop/switch region; other site 882095000353 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 882095000354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095000355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095000356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095000357 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882095000358 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882095000359 substrate binding pocket [chemical binding]; other site 882095000360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882095000361 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882095000363 ligand binding site [chemical binding]; other site 882095000364 flexible hinge region; other site 882095000365 Domain of unknown function (DUF955); Region: DUF955; pfam06114 882095000366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095000367 non-specific DNA binding site [nucleotide binding]; other site 882095000368 salt bridge; other site 882095000369 sequence-specific DNA binding site [nucleotide binding]; other site 882095000370 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 882095000371 Predicted secreted protein [Function unknown]; Region: COG5437 882095000372 Phage-related protein [Function unknown]; Region: COG5412 882095000373 Phage tail protein; Region: Sipho_tail; pfam05709 882095000374 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 882095000375 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 882095000376 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882095000377 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882095000378 active site 882095000379 metal binding site [ion binding]; metal-binding site 882095000380 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882095000381 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 882095000382 putative active site [active] 882095000383 putative metal binding site [ion binding]; other site 882095000384 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882095000385 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882095000386 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 882095000387 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 882095000388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 882095000389 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882095000390 active site 882095000391 Uncharacterized conserved protein [Function unknown]; Region: COG3592 882095000392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095000393 Coenzyme A binding pocket [chemical binding]; other site 882095000394 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 882095000395 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 882095000396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882095000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000398 dimer interface [polypeptide binding]; other site 882095000399 conserved gate region; other site 882095000400 putative PBP binding loops; other site 882095000401 ABC-ATPase subunit interface; other site 882095000402 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882095000403 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 882095000404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000405 dimer interface [polypeptide binding]; other site 882095000406 conserved gate region; other site 882095000407 putative PBP binding loops; other site 882095000408 ABC-ATPase subunit interface; other site 882095000409 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 882095000410 LXG domain of WXG superfamily; Region: LXG; pfam04740 882095000411 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 882095000412 phosphoenolpyruvate synthase; Validated; Region: PRK06464 882095000413 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882095000414 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882095000415 peptide binding site [polypeptide binding]; other site 882095000416 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882095000417 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882095000418 metal binding site [ion binding]; metal-binding site 882095000419 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 882095000420 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882095000421 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882095000422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095000423 ABC-ATPase subunit interface; other site 882095000424 dimer interface [polypeptide binding]; other site 882095000425 putative PBP binding regions; other site 882095000426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882095000427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000428 ligand binding site [chemical binding]; other site 882095000429 flexible hinge region; other site 882095000430 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 882095000431 DEAD_2; Region: DEAD_2; pfam06733 882095000432 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882095000433 sugar phosphate phosphatase; Provisional; Region: PRK10513 882095000434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000435 active site 882095000436 motif I; other site 882095000437 motif II; other site 882095000438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000439 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882095000440 Collagen binding domain; Region: Collagen_bind; pfam05737 882095000441 Cna protein B-type domain; Region: Cna_B; pfam05738 882095000442 Cna protein B-type domain; Region: Cna_B; pfam05738 882095000443 Cna protein B-type domain; Region: Cna_B; pfam05738 882095000444 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882095000445 Collagen binding domain; Region: Collagen_bind; pfam05737 882095000446 Cna protein B-type domain; Region: Cna_B; pfam05738 882095000447 Cna protein B-type domain; Region: Cna_B; pfam05738 882095000448 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882095000449 DNA polymerase III subunit delta'; Validated; Region: PRK08058 882095000450 DNA polymerase III subunit delta'; Validated; Region: PRK08485 882095000451 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 882095000452 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 882095000453 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 882095000454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095000455 S-adenosylmethionine binding site [chemical binding]; other site 882095000456 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 882095000457 GIY-YIG motif/motif A; other site 882095000458 putative active site [active] 882095000459 putative metal binding site [ion binding]; other site 882095000460 Predicted methyltransferases [General function prediction only]; Region: COG0313 882095000461 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 882095000462 putative SAM binding site [chemical binding]; other site 882095000463 putative homodimer interface [polypeptide binding]; other site 882095000464 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 882095000465 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 882095000466 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882095000467 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882095000468 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882095000469 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 882095000470 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095000471 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882095000472 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 882095000473 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 882095000474 active site 882095000475 HIGH motif; other site 882095000476 KMSKS motif; other site 882095000477 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 882095000478 tRNA binding surface [nucleotide binding]; other site 882095000479 anticodon binding site; other site 882095000480 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 882095000481 dimer interface [polypeptide binding]; other site 882095000482 putative tRNA-binding site [nucleotide binding]; other site 882095000483 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 882095000484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095000485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095000486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882095000487 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882095000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000489 dimer interface [polypeptide binding]; other site 882095000490 conserved gate region; other site 882095000491 putative PBP binding loops; other site 882095000492 ABC-ATPase subunit interface; other site 882095000493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000495 dimer interface [polypeptide binding]; other site 882095000496 conserved gate region; other site 882095000497 putative PBP binding loops; other site 882095000498 ABC-ATPase subunit interface; other site 882095000499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882095000500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095000501 alpha-glucosidase; Provisional; Region: PRK10426 882095000502 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882095000503 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882095000504 active site 882095000505 catalytic site [active] 882095000506 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882095000507 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882095000508 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 882095000509 trimer interface [polypeptide binding]; other site 882095000510 active site 882095000511 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 882095000512 catalytic site [active] 882095000513 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882095000514 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882095000515 Ca binding site [ion binding]; other site 882095000516 active site 882095000517 catalytic site [active] 882095000518 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 882095000519 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 882095000520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 882095000521 active site 882095000522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 882095000523 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882095000524 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882095000525 G5 domain; Region: G5; pfam07501 882095000526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882095000527 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 882095000528 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 882095000529 putative active site [active] 882095000530 putative metal binding site [ion binding]; other site 882095000531 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 882095000532 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 882095000533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095000534 S-adenosylmethionine binding site [chemical binding]; other site 882095000535 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 882095000536 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 882095000537 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882095000538 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 882095000539 putative active site [active] 882095000540 YdjC motif; other site 882095000541 Mg binding site [ion binding]; other site 882095000542 putative homodimer interface [polypeptide binding]; other site 882095000543 pur operon repressor; Provisional; Region: PRK09213 882095000544 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 882095000545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095000546 active site 882095000547 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 882095000548 HlyD family secretion protein; Region: HlyD_3; pfam13437 882095000549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095000550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095000551 Walker A/P-loop; other site 882095000552 ATP binding site [chemical binding]; other site 882095000553 Q-loop/lid; other site 882095000554 ABC transporter signature motif; other site 882095000555 Walker B; other site 882095000556 D-loop; other site 882095000557 H-loop/switch region; other site 882095000558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095000559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095000560 FtsX-like permease family; Region: FtsX; pfam02687 882095000561 regulatory protein SpoVG; Reviewed; Region: PRK13259 882095000562 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 882095000563 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 882095000564 Substrate binding site; other site 882095000565 Mg++ binding site; other site 882095000566 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 882095000567 active site 882095000568 substrate binding site [chemical binding]; other site 882095000569 CoA binding site [chemical binding]; other site 882095000570 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882095000571 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882095000572 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095000573 active site 882095000574 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000575 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095000576 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095000577 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 882095000578 active site 882095000579 catalytic site [active] 882095000580 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 882095000581 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 882095000582 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 882095000583 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882095000584 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 882095000585 active site 882095000586 Zn binding site [ion binding]; other site 882095000587 ActA Protein; Region: ActA; pfam05058 882095000588 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 882095000589 Zn binding site [ion binding]; other site 882095000590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 882095000591 hypothetical protein; Provisional; Region: PRK01119 882095000592 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882095000593 A new structural DNA glycosylase; Region: AlkD_like; cd06561 882095000594 active site 882095000595 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 882095000596 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882095000597 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095000598 NAD binding site [chemical binding]; other site 882095000599 dimer interface [polypeptide binding]; other site 882095000600 substrate binding site [chemical binding]; other site 882095000601 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 882095000602 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 882095000603 5S rRNA interface [nucleotide binding]; other site 882095000604 CTC domain interface [polypeptide binding]; other site 882095000605 L16 interface [polypeptide binding]; other site 882095000606 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095000607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095000608 Coenzyme A binding pocket [chemical binding]; other site 882095000609 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 882095000610 putative active site [active] 882095000611 catalytic residue [active] 882095000612 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 882095000613 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 882095000614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095000615 ATP binding site [chemical binding]; other site 882095000616 putative Mg++ binding site [ion binding]; other site 882095000617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095000618 nucleotide binding region [chemical binding]; other site 882095000619 ATP-binding site [chemical binding]; other site 882095000620 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 882095000621 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882095000622 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882095000623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095000624 RNA binding surface [nucleotide binding]; other site 882095000625 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 882095000626 Septum formation initiator; Region: DivIC; pfam04977 882095000627 hypothetical protein; Provisional; Region: PRK08582 882095000628 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882095000629 RNA binding site [nucleotide binding]; other site 882095000630 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 882095000631 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 882095000632 Ligand Binding Site [chemical binding]; other site 882095000633 TilS substrate C-terminal domain; Region: TilS_C; smart00977 882095000634 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882095000635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095000636 active site 882095000637 FtsH Extracellular; Region: FtsH_ext; pfam06480 882095000638 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 882095000639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095000640 Walker A motif; other site 882095000641 ATP binding site [chemical binding]; other site 882095000642 Walker B motif; other site 882095000643 arginine finger; other site 882095000644 Peptidase family M41; Region: Peptidase_M41; pfam01434 882095000645 pantothenate kinase; Reviewed; Region: PRK13318 882095000646 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 882095000647 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 882095000648 dimerization interface [polypeptide binding]; other site 882095000649 domain crossover interface; other site 882095000650 redox-dependent activation switch; other site 882095000651 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 882095000652 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 882095000653 dimer interface [polypeptide binding]; other site 882095000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095000655 catalytic residue [active] 882095000656 dihydropteroate synthase; Region: DHPS; TIGR01496 882095000657 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 882095000658 substrate binding pocket [chemical binding]; other site 882095000659 dimer interface [polypeptide binding]; other site 882095000660 inhibitor binding site; inhibition site 882095000661 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 882095000662 homooctamer interface [polypeptide binding]; other site 882095000663 active site 882095000664 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 882095000665 catalytic center binding site [active] 882095000666 ATP binding site [chemical binding]; other site 882095000667 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 882095000668 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 882095000669 FMN binding site [chemical binding]; other site 882095000670 active site 882095000671 catalytic residues [active] 882095000672 substrate binding site [chemical binding]; other site 882095000673 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 882095000674 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 882095000675 dimer interface [polypeptide binding]; other site 882095000676 putative anticodon binding site; other site 882095000677 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 882095000678 motif 1; other site 882095000679 active site 882095000680 motif 2; other site 882095000681 motif 3; other site 882095000682 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 882095000683 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 882095000684 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 882095000685 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 882095000686 ADP binding site [chemical binding]; other site 882095000687 phosphagen binding site; other site 882095000688 substrate specificity loop; other site 882095000689 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 882095000690 Clp amino terminal domain; Region: Clp_N; pfam02861 882095000691 Clp amino terminal domain; Region: Clp_N; pfam02861 882095000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095000693 Walker A motif; other site 882095000694 ATP binding site [chemical binding]; other site 882095000695 Walker B motif; other site 882095000696 arginine finger; other site 882095000697 UvrB/uvrC motif; Region: UVR; pfam02151 882095000698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095000699 Walker A motif; other site 882095000700 ATP binding site [chemical binding]; other site 882095000701 Walker B motif; other site 882095000702 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882095000703 DNA repair protein RadA; Provisional; Region: PRK11823 882095000704 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 882095000705 Walker A motif/ATP binding site; other site 882095000706 ATP binding site [chemical binding]; other site 882095000707 Walker B motif; other site 882095000708 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 882095000709 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 882095000710 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 882095000711 putative active site [active] 882095000712 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882095000713 substrate binding site; other site 882095000714 dimer interface; other site 882095000715 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 882095000716 homotrimer interaction site [polypeptide binding]; other site 882095000717 zinc binding site [ion binding]; other site 882095000718 CDP-binding sites; other site 882095000719 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 882095000720 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882095000721 HIGH motif; other site 882095000722 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882095000723 active site 882095000724 KMSKS motif; other site 882095000725 serine O-acetyltransferase; Region: cysE; TIGR01172 882095000726 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 882095000727 trimer interface [polypeptide binding]; other site 882095000728 active site 882095000729 substrate binding site [chemical binding]; other site 882095000730 CoA binding site [chemical binding]; other site 882095000731 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 882095000732 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882095000733 active site 882095000734 HIGH motif; other site 882095000735 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882095000736 KMSKS motif; other site 882095000737 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 882095000738 tRNA binding surface [nucleotide binding]; other site 882095000739 anticodon binding site; other site 882095000740 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882095000741 active site 882095000742 metal binding site [ion binding]; metal-binding site 882095000743 dimerization interface [polypeptide binding]; other site 882095000744 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882095000745 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 882095000746 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882095000747 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 882095000748 RNA polymerase factor sigma-70; Validated; Region: PRK08295 882095000749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882095000750 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 882095000751 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 882095000752 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 882095000753 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 882095000754 putative homodimer interface [polypeptide binding]; other site 882095000755 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 882095000756 heterodimer interface [polypeptide binding]; other site 882095000757 homodimer interface [polypeptide binding]; other site 882095000758 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 882095000759 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 882095000760 23S rRNA interface [nucleotide binding]; other site 882095000761 L7/L12 interface [polypeptide binding]; other site 882095000762 putative thiostrepton binding site; other site 882095000763 L25 interface [polypeptide binding]; other site 882095000764 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 882095000765 mRNA/rRNA interface [nucleotide binding]; other site 882095000766 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 882095000767 23S rRNA interface [nucleotide binding]; other site 882095000768 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 882095000769 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 882095000770 core dimer interface [polypeptide binding]; other site 882095000771 peripheral dimer interface [polypeptide binding]; other site 882095000772 L10 interface [polypeptide binding]; other site 882095000773 L11 interface [polypeptide binding]; other site 882095000774 putative EF-Tu interaction site [polypeptide binding]; other site 882095000775 putative EF-G interaction site [polypeptide binding]; other site 882095000776 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882095000777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095000778 S-adenosylmethionine binding site [chemical binding]; other site 882095000779 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 882095000780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095000781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095000782 DNA binding site [nucleotide binding] 882095000783 domain linker motif; other site 882095000784 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882095000785 putative dimerization interface [polypeptide binding]; other site 882095000786 putative ligand binding site [chemical binding]; other site 882095000787 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 882095000788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095000789 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882095000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000791 dimer interface [polypeptide binding]; other site 882095000792 conserved gate region; other site 882095000793 putative PBP binding loops; other site 882095000794 ABC-ATPase subunit interface; other site 882095000795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095000796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000797 dimer interface [polypeptide binding]; other site 882095000798 conserved gate region; other site 882095000799 putative PBP binding loops; other site 882095000800 ABC-ATPase subunit interface; other site 882095000801 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882095000802 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882095000803 Ca binding site [ion binding]; other site 882095000804 active site 882095000805 catalytic site [active] 882095000806 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 882095000807 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882095000808 active site 882095000809 homodimer interface [polypeptide binding]; other site 882095000810 catalytic site [active] 882095000811 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 882095000812 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882095000813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882095000814 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 882095000815 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882095000816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 882095000817 RPB10 interaction site [polypeptide binding]; other site 882095000818 RPB1 interaction site [polypeptide binding]; other site 882095000819 RPB11 interaction site [polypeptide binding]; other site 882095000820 RPB3 interaction site [polypeptide binding]; other site 882095000821 RPB12 interaction site [polypeptide binding]; other site 882095000822 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 882095000823 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 882095000824 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 882095000825 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 882095000826 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 882095000827 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882095000828 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 882095000829 G-loop; other site 882095000830 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882095000831 DNA binding site [nucleotide binding] 882095000832 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 882095000833 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 882095000834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000835 active site 882095000836 motif I; other site 882095000837 motif II; other site 882095000838 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095000839 beta-galactosidase; Region: BGL; TIGR03356 882095000840 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882095000841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 882095000842 Walker A/P-loop; other site 882095000843 ATP binding site [chemical binding]; other site 882095000844 Q-loop/lid; other site 882095000845 ABC transporter signature motif; other site 882095000846 Walker B; other site 882095000847 D-loop; other site 882095000848 H-loop/switch region; other site 882095000849 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882095000850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095000851 Walker A/P-loop; other site 882095000852 ATP binding site [chemical binding]; other site 882095000853 Q-loop/lid; other site 882095000854 ABC transporter signature motif; other site 882095000855 Walker B; other site 882095000856 D-loop; other site 882095000857 H-loop/switch region; other site 882095000858 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095000859 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095000860 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095000861 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095000862 LRR adjacent; Region: LRR_adjacent; pfam08191 882095000863 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095000864 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095000865 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095000866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000867 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000868 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000870 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095000871 LRR adjacent; Region: LRR_adjacent; pfam08191 882095000872 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095000873 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095000874 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095000875 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000876 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000877 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095000878 Leucine-rich repeats; other site 882095000879 Substrate binding site [chemical binding]; other site 882095000880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000881 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000882 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000883 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000884 LRR adjacent; Region: LRR_adjacent; pfam08191 882095000885 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095000886 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095000887 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 882095000888 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 882095000889 metal binding site [ion binding]; metal-binding site 882095000890 dimer interface [polypeptide binding]; other site 882095000891 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095000892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095000893 putative Zn2+ binding site [ion binding]; other site 882095000894 putative DNA binding site [nucleotide binding]; other site 882095000895 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882095000896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095000897 Zn binding site [ion binding]; other site 882095000898 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882095000899 Zn binding site [ion binding]; other site 882095000900 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095000901 catalytic core [active] 882095000902 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 882095000903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882095000904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882095000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000906 dimer interface [polypeptide binding]; other site 882095000907 conserved gate region; other site 882095000908 ABC-ATPase subunit interface; other site 882095000909 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095000910 Substrate binding site [chemical binding]; other site 882095000911 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000912 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000913 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000914 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000915 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095000916 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882095000917 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095000918 beta-galactosidase; Region: BGL; TIGR03356 882095000919 sugar phosphate phosphatase; Provisional; Region: PRK10513 882095000920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000921 active site 882095000922 motif I; other site 882095000923 motif II; other site 882095000924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095000926 Coenzyme A binding pocket [chemical binding]; other site 882095000927 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000928 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 882095000929 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882095000930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882095000931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000932 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 882095000933 active site 882095000934 motif I; other site 882095000935 motif II; other site 882095000936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095000937 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095000938 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095000939 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882095000940 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 882095000941 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 882095000942 Walker A/P-loop; other site 882095000943 ATP binding site [chemical binding]; other site 882095000944 Q-loop/lid; other site 882095000945 ABC transporter signature motif; other site 882095000946 Walker B; other site 882095000947 D-loop; other site 882095000948 H-loop/switch region; other site 882095000949 TOBE domain; Region: TOBE; pfam03459 882095000950 ATP cone domain; Region: ATP-cone; pfam03477 882095000951 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 882095000952 Class III ribonucleotide reductase; Region: RNR_III; cd01675 882095000953 effector binding site; other site 882095000954 active site 882095000955 Zn binding site [ion binding]; other site 882095000956 glycine loop; other site 882095000957 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 882095000958 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 882095000959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095000960 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095000961 ligand binding site [chemical binding]; other site 882095000962 flexible hinge region; other site 882095000963 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882095000964 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 882095000965 putative active site [active] 882095000966 catalytic triad [active] 882095000967 putative dimer interface [polypeptide binding]; other site 882095000968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095000969 dimer interface [polypeptide binding]; other site 882095000970 conserved gate region; other site 882095000971 ABC-ATPase subunit interface; other site 882095000972 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 882095000973 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882095000974 Walker A/P-loop; other site 882095000975 ATP binding site [chemical binding]; other site 882095000976 Q-loop/lid; other site 882095000977 ABC transporter signature motif; other site 882095000978 Walker B; other site 882095000979 D-loop; other site 882095000980 H-loop/switch region; other site 882095000981 NIL domain; Region: NIL; pfam09383 882095000982 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882095000983 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882095000984 transaminase; Reviewed; Region: PRK08068 882095000985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095000986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095000987 homodimer interface [polypeptide binding]; other site 882095000988 catalytic residue [active] 882095000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095000991 active site 882095000992 phosphorylation site [posttranslational modification] 882095000993 intermolecular recognition site; other site 882095000994 dimerization interface [polypeptide binding]; other site 882095000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095000996 DNA binding site [nucleotide binding] 882095000997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 882095000998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095000999 dimerization interface [polypeptide binding]; other site 882095001000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882095001001 putative active site [active] 882095001002 heme pocket [chemical binding]; other site 882095001003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095001004 dimer interface [polypeptide binding]; other site 882095001005 phosphorylation site [posttranslational modification] 882095001006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095001007 ATP binding site [chemical binding]; other site 882095001008 Mg2+ binding site [ion binding]; other site 882095001009 G-X-G motif; other site 882095001010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 882095001011 YycH protein; Region: YycH; pfam07435 882095001012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 882095001013 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 882095001014 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882095001015 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882095001016 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 882095001017 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882095001018 protein binding site [polypeptide binding]; other site 882095001019 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 882095001020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095001021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095001022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882095001023 dimerization interface [polypeptide binding]; other site 882095001024 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882095001025 dimer interface [polypeptide binding]; other site 882095001026 FMN binding site [chemical binding]; other site 882095001027 NADPH bind site [chemical binding]; other site 882095001028 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095001029 HTH domain; Region: HTH_11; pfam08279 882095001030 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095001031 PRD domain; Region: PRD; pfam00874 882095001032 PRD domain; Region: PRD; pfam00874 882095001033 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095001034 active site 882095001035 P-loop; other site 882095001036 phosphorylation site [posttranslational modification] 882095001037 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001038 active site 882095001039 phosphorylation site [posttranslational modification] 882095001040 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095001041 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095001042 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095001043 active site 882095001044 P-loop; other site 882095001045 phosphorylation site [posttranslational modification] 882095001046 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095001047 beta-galactosidase; Region: BGL; TIGR03356 882095001048 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095001049 methionine cluster; other site 882095001050 active site 882095001051 phosphorylation site [posttranslational modification] 882095001052 metal binding site [ion binding]; metal-binding site 882095001053 HsdM N-terminal domain; Region: HsdM_N; pfam12161 882095001054 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 882095001055 Methyltransferase domain; Region: Methyltransf_26; pfam13659 882095001056 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 882095001057 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 882095001058 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 882095001059 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 882095001060 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 882095001061 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 882095001062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095001063 ATP binding site [chemical binding]; other site 882095001064 putative Mg++ binding site [ion binding]; other site 882095001065 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 882095001066 Mrr N-terminal domain; Region: Mrr_N; pfam14338 882095001067 Restriction endonuclease; Region: Mrr_cat; pfam04471 882095001068 Part of AAA domain; Region: AAA_19; pfam13245 882095001069 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 882095001070 AAA domain; Region: AAA_12; pfam13087 882095001071 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 882095001072 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882095001073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095001074 catalytic residue [active] 882095001075 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 882095001076 putative active site [active] 882095001077 YdjC motif; other site 882095001078 Mg binding site [ion binding]; other site 882095001079 putative homodimer interface [polypeptide binding]; other site 882095001080 Putative transcription activator [Transcription]; Region: TenA; COG0819 882095001081 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 882095001082 substrate binding site [chemical binding]; other site 882095001083 multimerization interface [polypeptide binding]; other site 882095001084 ATP binding site [chemical binding]; other site 882095001085 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882095001086 dimer interface [polypeptide binding]; other site 882095001087 substrate binding site [chemical binding]; other site 882095001088 ATP binding site [chemical binding]; other site 882095001089 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 882095001090 thiamine phosphate binding site [chemical binding]; other site 882095001091 active site 882095001092 pyrophosphate binding site [ion binding]; other site 882095001093 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882095001094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095001095 non-specific DNA binding site [nucleotide binding]; other site 882095001096 salt bridge; other site 882095001097 sequence-specific DNA binding site [nucleotide binding]; other site 882095001098 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 882095001099 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 882095001100 cofactor binding site; other site 882095001101 DNA binding site [nucleotide binding] 882095001102 substrate interaction site [chemical binding]; other site 882095001103 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 882095001104 ATP binding site [chemical binding]; other site 882095001105 Mg2+ binding site [ion binding]; other site 882095001106 G-X-G motif; other site 882095001107 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095001108 beta-galactosidase; Region: BGL; TIGR03356 882095001109 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001110 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 882095001111 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 882095001112 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 882095001113 putative catalytic site [active] 882095001114 putative metal binding site [ion binding]; other site 882095001115 putative phosphate binding site [ion binding]; other site 882095001116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095001117 non-specific DNA binding site [nucleotide binding]; other site 882095001118 salt bridge; other site 882095001119 sequence-specific DNA binding site [nucleotide binding]; other site 882095001120 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882095001121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095001122 non-specific DNA binding site [nucleotide binding]; other site 882095001123 salt bridge; other site 882095001124 sequence-specific DNA binding site [nucleotide binding]; other site 882095001125 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882095001126 Leucine rich repeat; Region: LRR_8; pfam13855 882095001127 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001128 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001129 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001130 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001131 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001132 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001133 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001134 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001135 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001136 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001137 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001138 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001139 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001140 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001141 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001142 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001143 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001144 Leucine rich repeat; Region: LRR_8; pfam13855 882095001145 Leucine rich repeat; Region: LRR_8; pfam13855 882095001146 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001147 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001148 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095001149 Leucine-rich repeats; other site 882095001150 Substrate binding site [chemical binding]; other site 882095001151 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001152 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001153 Leucine rich repeat; Region: LRR_8; pfam13855 882095001154 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095001155 Leucine-rich repeats; other site 882095001156 Leucine rich repeat; Region: LRR_8; pfam13855 882095001157 Substrate binding site [chemical binding]; other site 882095001158 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001159 Leucine rich repeat; Region: LRR_8; pfam13855 882095001160 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001161 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001162 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001163 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001164 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001165 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001166 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001167 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 882095001168 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882095001169 LXG domain of WXG superfamily; Region: LXG; pfam04740 882095001170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095001171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095001172 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 882095001173 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882095001174 NAD binding site [chemical binding]; other site 882095001175 substrate binding site [chemical binding]; other site 882095001176 putative active site [active] 882095001177 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 882095001178 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882095001179 Magnesium ion binding site [ion binding]; other site 882095001180 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 882095001181 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 882095001182 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882095001183 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882095001184 TPP-binding site [chemical binding]; other site 882095001185 dimer interface [polypeptide binding]; other site 882095001186 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882095001187 PYR/PP interface [polypeptide binding]; other site 882095001188 dimer interface [polypeptide binding]; other site 882095001189 TPP binding site [chemical binding]; other site 882095001190 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095001191 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882095001192 active site 882095001193 intersubunit interactions; other site 882095001194 catalytic residue [active] 882095001195 short chain dehydrogenase; Provisional; Region: PRK06841 882095001196 classical (c) SDRs; Region: SDR_c; cd05233 882095001197 NAD(P) binding site [chemical binding]; other site 882095001198 active site 882095001199 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882095001200 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882095001201 substrate binding site [chemical binding]; other site 882095001202 dimer interface [polypeptide binding]; other site 882095001203 catalytic triad [active] 882095001204 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882095001205 DAK2 domain; Region: Dak2; cl03685 882095001206 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 882095001207 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882095001208 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 882095001209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095001210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095001211 putative DNA binding site [nucleotide binding]; other site 882095001212 putative Zn2+ binding site [ion binding]; other site 882095001213 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095001214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095001215 Coenzyme A binding pocket [chemical binding]; other site 882095001216 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095001217 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095001218 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001219 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001220 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001221 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882095001222 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882095001223 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882095001224 acyl-activating enzyme (AAE) consensus motif; other site 882095001225 acyl-activating enzyme (AAE) consensus motif; other site 882095001226 AMP binding site [chemical binding]; other site 882095001227 active site 882095001228 CoA binding site [chemical binding]; other site 882095001229 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 882095001230 L-aspartate oxidase; Provisional; Region: PRK06175 882095001231 putative oxidoreductase; Provisional; Region: PRK10206 882095001232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095001233 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882095001234 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001235 active site 882095001236 phosphorylation site [posttranslational modification] 882095001237 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 882095001238 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095001239 active site 882095001240 P-loop; other site 882095001241 phosphorylation site [posttranslational modification] 882095001242 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095001243 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882095001244 intersubunit interface [polypeptide binding]; other site 882095001245 active site 882095001246 zinc binding site [ion binding]; other site 882095001247 Na+ binding site [ion binding]; other site 882095001248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095001249 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 882095001250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095001251 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 882095001252 conserved cys residue [active] 882095001253 Predicted transcriptional regulator [Transcription]; Region: COG2378 882095001254 HTH domain; Region: HTH_11; pfam08279 882095001255 WYL domain; Region: WYL; pfam13280 882095001256 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 882095001257 nudix motif; other site 882095001258 hypothetical protein; Provisional; Region: PRK12378 882095001259 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 882095001260 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 882095001261 PhnA protein; Region: PhnA; pfam03831 882095001262 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095001263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095001264 DNA-binding site [nucleotide binding]; DNA binding site 882095001265 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882095001266 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095001267 beta-galactosidase; Region: BGL; TIGR03356 882095001268 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095001269 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882095001270 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095001271 active site 882095001272 P-loop; other site 882095001273 phosphorylation site [posttranslational modification] 882095001274 Predicted transcriptional regulator [Transcription]; Region: COG2378 882095001275 HTH domain; Region: HTH_11; pfam08279 882095001276 WYL domain; Region: WYL; pfam13280 882095001277 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882095001278 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095001279 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882095001280 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095001281 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 882095001282 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 882095001283 tetrameric interface [polypeptide binding]; other site 882095001284 NAD binding site [chemical binding]; other site 882095001285 catalytic residues [active] 882095001286 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 882095001287 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882095001288 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 882095001289 substrate binding site [chemical binding]; other site 882095001290 ATP binding site [chemical binding]; other site 882095001291 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 882095001292 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882095001293 PYR/PP interface [polypeptide binding]; other site 882095001294 dimer interface [polypeptide binding]; other site 882095001295 TPP binding site [chemical binding]; other site 882095001296 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882095001297 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 882095001298 TPP-binding site; other site 882095001299 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882095001300 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 882095001301 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882095001302 ligand binding site [chemical binding]; other site 882095001303 active site 882095001304 UGI interface [polypeptide binding]; other site 882095001305 catalytic site [active] 882095001306 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 882095001307 hypothetical protein; Provisional; Region: PRK13665 882095001308 Bacterial SH3 domain; Region: SH3_3; cl17532 882095001309 NlpC/P60 family; Region: NLPC_P60; pfam00877 882095001310 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095001311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095001312 Coenzyme A binding pocket [chemical binding]; other site 882095001313 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 882095001314 pyrroline-5-carboxylate reductase; Region: PLN02688 882095001315 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095001316 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001317 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882095001318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095001319 DNA-binding site [nucleotide binding]; DNA binding site 882095001320 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 882095001321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095001322 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095001323 Walker A/P-loop; other site 882095001324 ATP binding site [chemical binding]; other site 882095001325 Q-loop/lid; other site 882095001326 ABC transporter signature motif; other site 882095001327 Walker B; other site 882095001328 D-loop; other site 882095001329 H-loop/switch region; other site 882095001330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095001331 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095001332 FtsX-like permease family; Region: FtsX; pfam02687 882095001333 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 882095001334 putative hydrophobic ligand binding site [chemical binding]; other site 882095001335 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001336 active site 882095001337 phosphorylation site [posttranslational modification] 882095001338 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095001339 active site 882095001340 P-loop; other site 882095001341 phosphorylation site [posttranslational modification] 882095001342 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095001343 alpha-mannosidase; Provisional; Region: PRK09819 882095001344 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882095001345 active site 882095001346 metal binding site [ion binding]; metal-binding site 882095001347 catalytic site [active] 882095001348 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882095001349 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095001350 HTH domain; Region: HTH_11; pfam08279 882095001351 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095001352 PRD domain; Region: PRD; pfam00874 882095001353 PRD domain; Region: PRD; pfam00874 882095001354 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095001355 active site 882095001356 P-loop; other site 882095001357 phosphorylation site [posttranslational modification] 882095001358 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001359 active site 882095001360 phosphorylation site [posttranslational modification] 882095001361 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882095001362 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 882095001363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095001364 putative metal binding site [ion binding]; other site 882095001365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 882095001366 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882095001367 trimer interface [polypeptide binding]; other site 882095001368 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095001369 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001370 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095001371 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001372 Leucine-rich repeats; other site 882095001373 Substrate binding site [chemical binding]; other site 882095001374 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001376 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001377 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001378 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001379 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001380 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001381 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001382 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001383 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001384 phosphoenolpyruvate synthase; Validated; Region: PRK06241 882095001385 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882095001386 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882095001387 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 882095001388 ZIP Zinc transporter; Region: Zip; pfam02535 882095001389 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 882095001390 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 882095001391 NodB motif; other site 882095001392 active site 882095001393 catalytic site [active] 882095001394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095001395 non-specific DNA binding site [nucleotide binding]; other site 882095001396 salt bridge; other site 882095001397 sequence-specific DNA binding site [nucleotide binding]; other site 882095001398 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 882095001399 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095001400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095001401 active site 882095001402 motif I; other site 882095001403 motif II; other site 882095001404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095001405 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882095001406 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095001407 HTH domain; Region: HTH_11; pfam08279 882095001408 PRD domain; Region: PRD; pfam00874 882095001409 PRD domain; Region: PRD; pfam00874 882095001410 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095001411 active site 882095001412 P-loop; other site 882095001413 phosphorylation site [posttranslational modification] 882095001414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001415 active site 882095001416 phosphorylation site [posttranslational modification] 882095001417 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001418 active site 882095001419 phosphorylation site [posttranslational modification] 882095001420 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095001421 active site 882095001422 P-loop; other site 882095001423 phosphorylation site [posttranslational modification] 882095001424 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095001425 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882095001426 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882095001427 active site 882095001428 metal binding site [ion binding]; metal-binding site 882095001429 catalytic site [active] 882095001430 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882095001431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095001432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095001433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882095001434 dimerization interface [polypeptide binding]; other site 882095001435 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882095001436 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882095001437 active site 882095001438 substrate binding site [chemical binding]; other site 882095001439 trimer interface [polypeptide binding]; other site 882095001440 CoA binding site [chemical binding]; other site 882095001441 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 882095001442 classical (c) SDRs; Region: SDR_c; cd05233 882095001443 NAD(P) binding site [chemical binding]; other site 882095001444 active site 882095001445 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 882095001446 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 882095001447 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 882095001448 RHS Repeat; Region: RHS_repeat; pfam05593 882095001449 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 882095001450 RHS Repeat; Region: RHS_repeat; pfam05593 882095001451 RHS Repeat; Region: RHS_repeat; pfam05593 882095001452 RHS Repeat; Region: RHS_repeat; pfam05593 882095001453 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 882095001454 HEAT repeats; Region: HEAT_2; pfam13646 882095001455 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095001456 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095001457 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095001458 Substrate binding site [chemical binding]; other site 882095001459 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001460 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001461 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001462 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001463 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 882095001464 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095001465 Leucine rich repeat; Region: LRR_8; pfam13855 882095001466 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095001467 Leucine rich repeat; Region: LRR_8; pfam13855 882095001468 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001469 LRR adjacent; Region: LRR_adjacent; pfam08191 882095001470 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 882095001471 SH3-like domain; Region: SH3_8; pfam13457 882095001472 Predicted transcriptional regulator [Transcription]; Region: COG1959 882095001473 Transcriptional regulator; Region: Rrf2; pfam02082 882095001474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882095001475 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 882095001476 NAD(P) binding site [chemical binding]; other site 882095001477 active site 882095001478 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 882095001479 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 882095001480 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 882095001481 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 882095001482 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882095001483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882095001484 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882095001485 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 882095001486 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 882095001487 Predicted membrane protein [Function unknown]; Region: COG3619 882095001488 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 882095001489 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 882095001490 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 882095001491 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 882095001492 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 882095001493 Protein of unknown function DUF58; Region: DUF58; pfam01882 882095001494 MoxR-like ATPases [General function prediction only]; Region: COG0714 882095001495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095001496 Walker A motif; other site 882095001497 ATP binding site [chemical binding]; other site 882095001498 Walker B motif; other site 882095001499 arginine finger; other site 882095001500 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882095001501 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882095001502 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 882095001503 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 882095001504 Na binding site [ion binding]; other site 882095001505 Uncharacterized conserved protein [Function unknown]; Region: COG3535 882095001506 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 882095001507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095001508 nucleotide binding site [chemical binding]; other site 882095001509 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 882095001510 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095001511 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095001512 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001513 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001514 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001515 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001516 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001517 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 882095001518 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001519 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001520 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095001521 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001522 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001523 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001524 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095001525 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001526 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001527 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095001528 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095001529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095001530 Zn2+ binding site [ion binding]; other site 882095001531 Mg2+ binding site [ion binding]; other site 882095001532 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 882095001533 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 882095001534 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 882095001535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095001536 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 882095001537 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 882095001538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882095001539 FeS/SAM binding site; other site 882095001540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 882095001541 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 882095001542 LXG domain of WXG superfamily; Region: LXG; pfam04740 882095001543 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 882095001544 putative FMN binding site [chemical binding]; other site 882095001545 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 882095001546 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 882095001547 nudix motif; other site 882095001548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095001549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095001550 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882095001551 putative dimerization interface [polypeptide binding]; other site 882095001552 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882095001553 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882095001554 active site 882095001555 FMN binding site [chemical binding]; other site 882095001556 substrate binding site [chemical binding]; other site 882095001557 putative catalytic residue [active] 882095001558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 882095001559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095001560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095001561 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882095001562 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882095001563 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882095001564 shikimate binding site; other site 882095001565 NAD(P) binding site [chemical binding]; other site 882095001566 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 882095001567 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 882095001568 active site 882095001569 catalytic residue [active] 882095001570 dimer interface [polypeptide binding]; other site 882095001571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095001572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095001573 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 882095001574 dimerization interface [polypeptide binding]; other site 882095001575 substrate binding pocket [chemical binding]; other site 882095001576 Predicted acyl esterases [General function prediction only]; Region: COG2936 882095001577 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 882095001578 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 882095001579 active site 882095001580 catalytic triad [active] 882095001581 oxyanion hole [active] 882095001582 EamA-like transporter family; Region: EamA; pfam00892 882095001583 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 882095001584 EamA-like transporter family; Region: EamA; pfam00892 882095001585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 882095001586 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882095001587 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882095001588 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882095001589 substrate binding site [chemical binding]; other site 882095001590 hexamer interface [polypeptide binding]; other site 882095001591 metal binding site [ion binding]; metal-binding site 882095001592 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882095001593 catalytic residue [active] 882095001594 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095001595 PRD domain; Region: PRD; pfam00874 882095001596 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095001597 active site 882095001598 P-loop; other site 882095001599 phosphorylation site [posttranslational modification] 882095001600 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001601 active site 882095001602 phosphorylation site [posttranslational modification] 882095001603 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 882095001604 putative active site [active] 882095001605 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001606 active site 882095001607 phosphorylation site [posttranslational modification] 882095001608 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882095001609 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882095001610 substrate binding site [chemical binding]; other site 882095001611 hexamer interface [polypeptide binding]; other site 882095001612 metal binding site [ion binding]; metal-binding site 882095001613 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882095001614 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882095001615 putative NAD(P) binding site [chemical binding]; other site 882095001616 catalytic Zn binding site [ion binding]; other site 882095001617 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882095001618 active site 882095001619 P-loop; other site 882095001620 phosphorylation site [posttranslational modification] 882095001621 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882095001622 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882095001623 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882095001624 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882095001625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095001626 active site 882095001627 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 882095001628 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 882095001629 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 882095001630 catalytic triad [active] 882095001631 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 882095001632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095001633 MarR family; Region: MarR_2; pfam12802 882095001634 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001635 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882095001637 Ligand Binding Site [chemical binding]; other site 882095001638 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 882095001639 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882095001640 putative active site [active] 882095001641 putative metal binding site [ion binding]; other site 882095001642 Transposase domain (DUF772); Region: DUF772; pfam05598 882095001643 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 882095001644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001645 catalytic core [active] 882095001646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001647 Predicted membrane protein [Function unknown]; Region: COG3759 882095001648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095001649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095001650 putative substrate translocation pore; other site 882095001651 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882095001652 non-specific DNA interactions [nucleotide binding]; other site 882095001653 DNA binding site [nucleotide binding] 882095001654 sequence specific DNA binding site [nucleotide binding]; other site 882095001655 putative cAMP binding site [chemical binding]; other site 882095001656 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095001657 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882095001658 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882095001659 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882095001660 NAD binding site [chemical binding]; other site 882095001661 sugar binding site [chemical binding]; other site 882095001662 divalent metal binding site [ion binding]; other site 882095001663 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095001664 dimer interface [polypeptide binding]; other site 882095001665 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095001666 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095001667 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095001668 putative active site [active] 882095001669 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882095001670 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882095001671 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882095001672 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882095001673 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 882095001674 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882095001675 DNA binding residues [nucleotide binding] 882095001676 dimer interface [polypeptide binding]; other site 882095001677 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 882095001678 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 882095001679 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 882095001680 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 882095001681 DXD motif; other site 882095001682 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882095001683 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882095001684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882095001685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095001686 S-adenosylmethionine binding site [chemical binding]; other site 882095001687 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 882095001688 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 882095001689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095001690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095001691 DNA binding site [nucleotide binding] 882095001692 domain linker motif; other site 882095001693 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882095001694 putative dimerization interface [polypeptide binding]; other site 882095001695 putative ligand binding site [chemical binding]; other site 882095001696 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882095001697 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882095001698 NAD binding site [chemical binding]; other site 882095001699 sugar binding site [chemical binding]; other site 882095001700 divalent metal binding site [ion binding]; other site 882095001701 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095001702 dimer interface [polypeptide binding]; other site 882095001703 allantoate amidohydrolase; Reviewed; Region: PRK09290 882095001704 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 882095001705 active site 882095001706 metal binding site [ion binding]; metal-binding site 882095001707 dimer interface [polypeptide binding]; other site 882095001708 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882095001709 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 882095001710 metal binding site [ion binding]; metal-binding site 882095001711 putative dimer interface [polypeptide binding]; other site 882095001712 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 882095001713 Beta-lactamase; Region: Beta-lactamase; pfam00144 882095001714 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882095001715 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882095001716 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882095001717 intersubunit interface [polypeptide binding]; other site 882095001718 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 882095001719 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 882095001720 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 882095001721 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 882095001722 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 882095001723 Glucitol operon activator protein (GutM); Region: GutM; cl01890 882095001724 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 882095001725 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095001726 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 882095001727 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882095001728 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882095001729 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095001730 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 882095001731 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001732 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001733 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001734 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095001735 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882095001736 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882095001737 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882095001738 FOG: CBS domain [General function prediction only]; Region: COG0517 882095001739 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 882095001740 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 882095001741 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 882095001742 dimer interface [polypeptide binding]; other site 882095001743 active site 882095001744 metal binding site [ion binding]; metal-binding site 882095001745 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 882095001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095001747 putative substrate translocation pore; other site 882095001748 POT family; Region: PTR2; pfam00854 882095001749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001750 catalytic core [active] 882095001751 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001752 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001753 catalytic core [active] 882095001754 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095001755 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 882095001756 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 882095001757 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882095001758 Cl binding site [ion binding]; other site 882095001759 oligomer interface [polypeptide binding]; other site 882095001760 glutamate dehydrogenase; Provisional; Region: PRK09414 882095001761 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 882095001762 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 882095001763 NAD(P) binding site [chemical binding]; other site 882095001764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 882095001765 metal binding site [ion binding]; metal-binding site 882095001766 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 882095001767 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 882095001768 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 882095001769 substrate binding site [chemical binding]; other site 882095001770 glutamase interaction surface [polypeptide binding]; other site 882095001771 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 882095001772 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 882095001773 catalytic residues [active] 882095001774 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 882095001775 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 882095001776 putative active site [active] 882095001777 oxyanion strand; other site 882095001778 catalytic triad [active] 882095001779 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 882095001780 putative active site pocket [active] 882095001781 4-fold oligomerization interface [polypeptide binding]; other site 882095001782 metal binding residues [ion binding]; metal-binding site 882095001783 3-fold/trimer interface [polypeptide binding]; other site 882095001784 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 882095001785 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 882095001786 NAD binding site [chemical binding]; other site 882095001787 dimerization interface [polypeptide binding]; other site 882095001788 product binding site; other site 882095001789 substrate binding site [chemical binding]; other site 882095001790 zinc binding site [ion binding]; other site 882095001791 catalytic residues [active] 882095001792 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 882095001793 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 882095001794 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 882095001795 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882095001796 dimer interface [polypeptide binding]; other site 882095001797 motif 1; other site 882095001798 active site 882095001799 motif 2; other site 882095001800 motif 3; other site 882095001801 histidinol-phosphatase; Reviewed; Region: PRK08123 882095001802 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 882095001803 active site 882095001804 dimer interface [polypeptide binding]; other site 882095001805 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882095001806 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882095001807 DNA binding site [nucleotide binding] 882095001808 active site 882095001809 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 882095001810 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882095001811 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095001812 beta-galactosidase; Region: BGL; TIGR03356 882095001813 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095001814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095001815 DNA-binding site [nucleotide binding]; DNA binding site 882095001816 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882095001817 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001818 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095001819 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 882095001820 Uncharacterized conserved protein [Function unknown]; Region: COG2966 882095001821 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 882095001822 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 882095001823 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 882095001824 Predicted esterase [General function prediction only]; Region: COG0400 882095001825 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 882095001826 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 882095001827 putative RNA binding site [nucleotide binding]; other site 882095001828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095001829 S-adenosylmethionine binding site [chemical binding]; other site 882095001830 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 882095001831 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095001832 Bacterial SH3 domain; Region: SH3_3; pfam08239 882095001833 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095001834 NlpC/P60 family; Region: NLPC_P60; pfam00877 882095001835 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 882095001836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882095001837 ATP binding site [chemical binding]; other site 882095001838 putative Mg++ binding site [ion binding]; other site 882095001839 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882095001840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 882095001841 nucleotide binding region [chemical binding]; other site 882095001842 ATP-binding site [chemical binding]; other site 882095001843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882095001844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882095001845 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882095001846 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882095001847 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882095001848 UreD urease accessory protein; Region: UreD; cl00530 882095001849 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 882095001850 DNA photolyase; Region: DNA_photolyase; pfam00875 882095001851 Predicted membrane protein [Function unknown]; Region: COG4852 882095001852 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 882095001853 DAK2 domain; Region: Dak2; pfam02734 882095001854 EDD domain protein, DegV family; Region: DegV; TIGR00762 882095001855 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882095001856 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 882095001857 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882095001858 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 882095001859 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 882095001860 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 882095001861 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882095001862 homodimer interface [polypeptide binding]; other site 882095001863 substrate-cofactor binding pocket; other site 882095001864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095001865 catalytic residue [active] 882095001866 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882095001867 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095001868 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882095001869 ligand binding site [chemical binding]; other site 882095001870 flexible hinge region; other site 882095001871 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095001872 BioY family; Region: BioY; pfam02632 882095001873 Predicted transcriptional regulators [Transcription]; Region: COG1695 882095001874 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882095001875 Predicted membrane protein [Function unknown]; Region: COG4709 882095001876 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882095001877 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882095001878 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882095001879 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882095001880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882095001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095001882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882095001883 Coenzyme A binding pocket [chemical binding]; other site 882095001884 Tic20-like protein; Region: Tic20; pfam09685 882095001885 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 882095001886 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882095001887 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882095001888 MarR family; Region: MarR_2; pfam12802 882095001889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095001890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095001891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095001892 Walker A/P-loop; other site 882095001893 ATP binding site [chemical binding]; other site 882095001894 Q-loop/lid; other site 882095001895 ABC transporter signature motif; other site 882095001896 Walker B; other site 882095001897 D-loop; other site 882095001898 H-loop/switch region; other site 882095001899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095001900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095001901 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882095001902 Walker A/P-loop; other site 882095001903 ATP binding site [chemical binding]; other site 882095001904 Q-loop/lid; other site 882095001905 ABC transporter signature motif; other site 882095001906 Walker B; other site 882095001907 D-loop; other site 882095001908 H-loop/switch region; other site 882095001909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882095001910 active site residue [active] 882095001911 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095001912 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882095001913 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882095001914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882095001915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095001916 putative DNA binding site [nucleotide binding]; other site 882095001917 putative Zn2+ binding site [ion binding]; other site 882095001918 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 882095001919 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 882095001920 putative NAD(P) binding site [chemical binding]; other site 882095001921 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 882095001922 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882095001923 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 882095001924 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882095001925 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 882095001926 putative active site [active] 882095001927 catalytic site [active] 882095001928 putative metal binding site [ion binding]; other site 882095001929 Catalytic domain of Protein Kinases; Region: PKc; cd00180 882095001930 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882095001931 active site 882095001932 ATP binding site [chemical binding]; other site 882095001933 substrate binding site [chemical binding]; other site 882095001934 activation loop (A-loop); other site 882095001935 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 882095001936 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 882095001937 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882095001938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882095001939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095001940 Coenzyme A binding pocket [chemical binding]; other site 882095001941 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 882095001942 active site 882095001943 catalytic triad [active] 882095001944 oxyanion hole [active] 882095001945 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882095001946 domain interaction interfaces [polypeptide binding]; other site 882095001947 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882095001948 domain interaction interfaces [polypeptide binding]; other site 882095001949 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882095001950 domain interaction interfaces [polypeptide binding]; other site 882095001951 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882095001952 domain interaction interfaces [polypeptide binding]; other site 882095001953 Isochorismatase family; Region: Isochorismatase; pfam00857 882095001954 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 882095001955 catalytic triad [active] 882095001956 conserved cis-peptide bond; other site 882095001957 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095001958 PRD domain; Region: PRD; pfam00874 882095001959 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095001960 active site 882095001961 P-loop; other site 882095001962 phosphorylation site [posttranslational modification] 882095001963 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001964 active site 882095001965 phosphorylation site [posttranslational modification] 882095001966 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095001967 active site 882095001968 phosphorylation site [posttranslational modification] 882095001969 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 882095001970 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095001971 active site 882095001972 P-loop; other site 882095001973 phosphorylation site [posttranslational modification] 882095001974 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 882095001975 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 882095001976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095001977 motif II; other site 882095001978 Predicted transcriptional regulator [Transcription]; Region: COG1959 882095001979 Transcriptional regulator; Region: Rrf2; pfam02082 882095001980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095001981 S-adenosylmethionine binding site [chemical binding]; other site 882095001982 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882095001983 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095001984 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095001985 active site 882095001986 catalytic tetrad [active] 882095001987 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 882095001988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095001989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095001990 motif II; other site 882095001991 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882095001992 catalytic residue [active] 882095001993 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882095001994 Sulfatase; Region: Sulfatase; pfam00884 882095001995 amino acid transporter; Region: 2A0306; TIGR00909 882095001996 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882095001997 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 882095001998 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 882095001999 putative metal binding site [ion binding]; other site 882095002000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 882095002001 active site 882095002002 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882095002003 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882095002004 Cl binding site [ion binding]; other site 882095002005 oligomer interface [polypeptide binding]; other site 882095002006 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882095002007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002008 DNA-binding site [nucleotide binding]; DNA binding site 882095002009 Predicted membrane protein [Function unknown]; Region: COG1511 882095002010 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882095002011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002012 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882095002013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002014 DNA-binding site [nucleotide binding]; DNA binding site 882095002015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882095002016 Predicted integral membrane protein [Function unknown]; Region: COG5523 882095002017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882095002018 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 882095002019 active site 882095002020 metal binding site [ion binding]; metal-binding site 882095002021 Predicted membrane protein [Function unknown]; Region: COG2322 882095002022 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 882095002023 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882095002024 minor groove reading motif; other site 882095002025 helix-hairpin-helix signature motif; other site 882095002026 substrate binding pocket [chemical binding]; other site 882095002027 active site 882095002028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095002029 non-specific DNA binding site [nucleotide binding]; other site 882095002030 salt bridge; other site 882095002031 sequence-specific DNA binding site [nucleotide binding]; other site 882095002032 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882095002033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 882095002034 Transposase; Region: HTH_Tnp_1; cl17663 882095002035 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095002036 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002037 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002038 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 882095002039 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882095002040 dimer interface [polypeptide binding]; other site 882095002041 substrate binding site [chemical binding]; other site 882095002042 ATP binding site [chemical binding]; other site 882095002043 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095002044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095002045 active site 882095002046 motif I; other site 882095002047 motif II; other site 882095002048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095002049 maltose O-acetyltransferase; Provisional; Region: PRK10092 882095002050 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882095002051 active site 882095002052 substrate binding site [chemical binding]; other site 882095002053 trimer interface [polypeptide binding]; other site 882095002054 CoA binding site [chemical binding]; other site 882095002055 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 882095002056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095002057 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 882095002058 Walker A/P-loop; other site 882095002059 ATP binding site [chemical binding]; other site 882095002060 Q-loop/lid; other site 882095002061 ABC transporter signature motif; other site 882095002062 Walker B; other site 882095002063 D-loop; other site 882095002064 H-loop/switch region; other site 882095002065 inner membrane transport permease; Provisional; Region: PRK15066 882095002066 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882095002067 oxidoreductase; Provisional; Region: PRK07985 882095002068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882095002069 NAD(P) binding site [chemical binding]; other site 882095002070 active site 882095002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 882095002072 Predicted membrane protein [Function unknown]; Region: COG3152 882095002073 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 882095002074 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 882095002075 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 882095002076 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 882095002077 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 882095002078 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 882095002079 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 882095002080 FHIPEP family; Region: FHIPEP; pfam00771 882095002081 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 882095002082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882095002083 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 882095002084 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882095002085 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 882095002086 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 882095002087 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 882095002088 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 882095002089 flagellar motor protein MotA; Validated; Region: PRK08124 882095002090 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 882095002091 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 882095002092 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 882095002093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 882095002094 ligand binding site [chemical binding]; other site 882095002095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882095002096 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 882095002097 putative metal binding site; other site 882095002098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095002099 binding surface 882095002100 TPR motif; other site 882095002101 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 882095002102 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 882095002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095002104 active site 882095002105 phosphorylation site [posttranslational modification] 882095002106 intermolecular recognition site; other site 882095002107 dimerization interface [polypeptide binding]; other site 882095002108 flagellin; Provisional; Region: PRK12805 882095002109 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882095002110 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 882095002111 Response regulator receiver domain; Region: Response_reg; pfam00072 882095002112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095002113 active site 882095002114 phosphorylation site [posttranslational modification] 882095002115 intermolecular recognition site; other site 882095002116 dimerization interface [polypeptide binding]; other site 882095002117 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 882095002118 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 882095002119 putative binding surface; other site 882095002120 active site 882095002121 P2 response regulator binding domain; Region: P2; pfam07194 882095002122 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 882095002123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095002124 ATP binding site [chemical binding]; other site 882095002125 Mg2+ binding site [ion binding]; other site 882095002126 G-X-G motif; other site 882095002127 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 882095002128 flagellar motor switch protein; Validated; Region: PRK06788 882095002129 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 882095002130 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 882095002131 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 882095002132 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 882095002133 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 882095002134 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 882095002135 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882095002136 flagellar motor switch protein; Validated; Region: PRK06789 882095002137 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 882095002138 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 882095002139 flagellar motor switch protein; Reviewed; Region: PRK06782 882095002140 CheC-like family; Region: CheC; pfam04509 882095002141 CheC-like family; Region: CheC; pfam04509 882095002142 Chemotaxis phosphatase CheX; Region: CheX; cl15816 882095002143 CheC-like family; Region: CheC; pfam04509 882095002144 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 882095002145 Protein of unknown function (DUF327); Region: DUF327; pfam03885 882095002146 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 882095002147 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882095002148 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 882095002149 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882095002150 flagellar capping protein; Validated; Region: fliD; PRK06798 882095002151 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 882095002152 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 882095002153 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 882095002154 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 882095002155 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 882095002156 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882095002157 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 882095002158 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 882095002159 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 882095002160 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 882095002161 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 882095002162 FliG C-terminal domain; Region: FliG_C; pfam01706 882095002163 flagellar assembly protein H; Validated; Region: fliH; PRK06800 882095002164 Flagellar assembly protein FliH; Region: FliH; pfam02108 882095002165 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 882095002166 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882095002167 Walker A motif; other site 882095002168 ATP binding site [chemical binding]; other site 882095002169 Walker B motif; other site 882095002170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 882095002171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 882095002172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 882095002173 catalytic residue [active] 882095002174 Predicted transcriptional regulators [Transcription]; Region: COG1695 882095002175 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882095002176 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 882095002177 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 882095002178 pyruvate oxidase; Provisional; Region: PRK08611 882095002179 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 882095002180 PYR/PP interface [polypeptide binding]; other site 882095002181 dimer interface [polypeptide binding]; other site 882095002182 tetramer interface [polypeptide binding]; other site 882095002183 TPP binding site [chemical binding]; other site 882095002184 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882095002185 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 882095002186 TPP-binding site [chemical binding]; other site 882095002187 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 882095002188 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882095002189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095002190 dimerization interface [polypeptide binding]; other site 882095002191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882095002192 dimer interface [polypeptide binding]; other site 882095002193 putative CheW interface [polypeptide binding]; other site 882095002194 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882095002195 putative active site [active] 882095002196 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 882095002197 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 882095002198 glutaminase active site [active] 882095002199 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882095002200 dimer interface [polypeptide binding]; other site 882095002201 active site 882095002202 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882095002203 dimer interface [polypeptide binding]; other site 882095002204 active site 882095002205 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 882095002206 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882095002207 active site 882095002208 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 882095002209 GIY-YIG motif/motif A; other site 882095002210 Leucine rich repeat; Region: LRR_8; pfam13855 882095002211 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002212 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002213 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882095002215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095002216 non-specific DNA binding site [nucleotide binding]; other site 882095002217 salt bridge; other site 882095002218 sequence-specific DNA binding site [nucleotide binding]; other site 882095002219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095002220 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095002221 ligand binding site [chemical binding]; other site 882095002222 flexible hinge region; other site 882095002223 Predicted transcriptional regulators [Transcription]; Region: COG1725 882095002224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002225 DNA-binding site [nucleotide binding]; DNA binding site 882095002226 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882095002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095002228 Walker A/P-loop; other site 882095002229 ATP binding site [chemical binding]; other site 882095002230 Q-loop/lid; other site 882095002231 ABC transporter signature motif; other site 882095002232 Walker B; other site 882095002233 D-loop; other site 882095002234 H-loop/switch region; other site 882095002235 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095002236 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095002237 Walker A/P-loop; other site 882095002238 ATP binding site [chemical binding]; other site 882095002239 Q-loop/lid; other site 882095002240 ABC transporter signature motif; other site 882095002241 Walker B; other site 882095002242 D-loop; other site 882095002243 H-loop/switch region; other site 882095002244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095002245 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095002246 FtsX-like permease family; Region: FtsX; pfam02687 882095002247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882095002248 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095002249 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882095002250 ligand binding site [chemical binding]; other site 882095002251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882095002252 non-specific DNA interactions [nucleotide binding]; other site 882095002253 DNA binding site [nucleotide binding] 882095002254 sequence specific DNA binding site [nucleotide binding]; other site 882095002255 putative cAMP binding site [chemical binding]; other site 882095002256 SnoaL-like domain; Region: SnoaL_4; pfam13577 882095002257 Transposase domain (DUF772); Region: DUF772; pfam05598 882095002258 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 882095002259 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 882095002260 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 882095002261 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882095002262 active site 882095002263 catalytic triad [active] 882095002264 oxyanion hole [active] 882095002265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095002266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095002267 Walker A/P-loop; other site 882095002268 ATP binding site [chemical binding]; other site 882095002269 Q-loop/lid; other site 882095002270 ABC transporter signature motif; other site 882095002271 Walker B; other site 882095002272 D-loop; other site 882095002273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882095002274 H-loop/switch region; other site 882095002275 active site 882095002276 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 882095002277 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882095002278 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882095002279 Zn binding site [ion binding]; other site 882095002280 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882095002281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095002282 Zn binding site [ion binding]; other site 882095002283 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882095002284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095002285 Zn binding site [ion binding]; other site 882095002286 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882095002287 Zn binding site [ion binding]; other site 882095002288 Predicted esterase [General function prediction only]; Region: COG0400 882095002289 putative hydrolase; Provisional; Region: PRK11460 882095002290 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 882095002291 GTPases [General function prediction only]; Region: HflX; COG2262 882095002292 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882095002293 HflX GTPase family; Region: HflX; cd01878 882095002294 G1 box; other site 882095002295 GTP/Mg2+ binding site [chemical binding]; other site 882095002296 Switch I region; other site 882095002297 G2 box; other site 882095002298 G3 box; other site 882095002299 Switch II region; other site 882095002300 G4 box; other site 882095002301 G5 box; other site 882095002302 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882095002303 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882095002304 putative active site [active] 882095002305 putative metal binding site [ion binding]; other site 882095002306 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882095002307 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882095002308 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882095002309 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882095002310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002311 DNA-binding site [nucleotide binding]; DNA binding site 882095002312 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 882095002313 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 882095002314 putative NADP binding site [chemical binding]; other site 882095002315 putative dimer interface [polypeptide binding]; other site 882095002316 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 882095002317 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882095002318 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095002319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095002320 nucleotide binding site [chemical binding]; other site 882095002321 Predicted membrane protein [Function unknown]; Region: COG4811 882095002322 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 882095002323 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882095002324 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882095002325 active site 882095002326 phosphorylation site [posttranslational modification] 882095002327 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095002328 active pocket/dimerization site; other site 882095002329 active site 882095002330 phosphorylation site [posttranslational modification] 882095002331 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882095002332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095002333 Walker A motif; other site 882095002334 ATP binding site [chemical binding]; other site 882095002335 Walker B motif; other site 882095002336 arginine finger; other site 882095002337 Transcriptional antiterminator [Transcription]; Region: COG3933 882095002338 PRD domain; Region: PRD; pfam00874 882095002339 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095002340 active pocket/dimerization site; other site 882095002341 active site 882095002342 phosphorylation site [posttranslational modification] 882095002343 PRD domain; Region: PRD; pfam00874 882095002344 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 882095002345 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882095002346 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 882095002347 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882095002348 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 882095002349 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882095002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 882095002351 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 882095002352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 882095002353 Leucine rich repeat; Region: LRR_8; pfam13855 882095002354 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002355 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002356 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002357 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002358 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002359 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095002360 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 882095002361 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882095002362 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 882095002363 putative deacylase active site [active] 882095002364 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882095002365 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 882095002366 active site 882095002367 catalytic triad [active] 882095002368 dimer interface [polypeptide binding]; other site 882095002369 Protein of unknown function (DUF554); Region: DUF554; pfam04474 882095002370 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 882095002371 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882095002372 NAD binding site [chemical binding]; other site 882095002373 substrate binding site [chemical binding]; other site 882095002374 putative active site [active] 882095002375 Predicted permeases [General function prediction only]; Region: RarD; COG2962 882095002376 EamA-like transporter family; Region: EamA; pfam00892 882095002377 Uncharacterized conserved protein [Function unknown]; Region: COG2353 882095002378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882095002379 MarR family; Region: MarR_2; pfam12802 882095002380 lysine transporter; Provisional; Region: PRK10836 882095002381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882095002382 PAS domain; Region: PAS_9; pfam13426 882095002383 putative active site [active] 882095002384 heme pocket [chemical binding]; other site 882095002385 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882095002386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 882095002387 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882095002388 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882095002389 synthetase active site [active] 882095002390 NTP binding site [chemical binding]; other site 882095002391 metal binding site [ion binding]; metal-binding site 882095002392 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882095002393 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 882095002394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095002395 non-specific DNA binding site [nucleotide binding]; other site 882095002396 salt bridge; other site 882095002397 sequence-specific DNA binding site [nucleotide binding]; other site 882095002398 Cupin domain; Region: Cupin_2; pfam07883 882095002399 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 882095002400 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 882095002401 Walker A/P-loop; other site 882095002402 ATP binding site [chemical binding]; other site 882095002403 Q-loop/lid; other site 882095002404 ABC transporter signature motif; other site 882095002405 Walker B; other site 882095002406 D-loop; other site 882095002407 H-loop/switch region; other site 882095002408 TOBE domain; Region: TOBE_2; pfam08402 882095002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882095002410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095002411 putative PBP binding loops; other site 882095002412 ABC-ATPase subunit interface; other site 882095002413 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 882095002414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095002415 dimer interface [polypeptide binding]; other site 882095002416 conserved gate region; other site 882095002417 putative PBP binding loops; other site 882095002418 ABC-ATPase subunit interface; other site 882095002419 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 882095002420 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 882095002421 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 882095002422 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 882095002423 active site 882095002424 zinc binding site [ion binding]; other site 882095002425 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882095002426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095002427 Zn2+ binding site [ion binding]; other site 882095002428 Mg2+ binding site [ion binding]; other site 882095002429 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095002430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095002431 nucleotide binding site [chemical binding]; other site 882095002432 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882095002433 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882095002434 FMN binding site [chemical binding]; other site 882095002435 substrate binding site [chemical binding]; other site 882095002436 putative catalytic residue [active] 882095002437 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882095002438 LXG domain of WXG superfamily; Region: LXG; pfam04740 882095002439 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882095002440 dimer interface [polypeptide binding]; other site 882095002441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095002442 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 882095002443 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882095002444 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095002445 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882095002446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095002447 motif II; other site 882095002448 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882095002449 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095002450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095002451 Coenzyme A binding pocket [chemical binding]; other site 882095002452 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 882095002453 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095002454 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095002455 DNA binding residues [nucleotide binding] 882095002456 putative dimer interface [polypeptide binding]; other site 882095002457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095002458 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095002459 active site 882095002460 catalytic tetrad [active] 882095002461 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882095002462 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 882095002463 homodimer interface [polypeptide binding]; other site 882095002464 catalytic residues [active] 882095002465 NAD binding site [chemical binding]; other site 882095002466 substrate binding pocket [chemical binding]; other site 882095002467 flexible flap; other site 882095002468 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 882095002469 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882095002470 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882095002471 PhoU domain; Region: PhoU; pfam01895 882095002472 PhoU domain; Region: PhoU; pfam01895 882095002473 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 882095002474 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 882095002475 dimer interface [polypeptide binding]; other site 882095002476 PYR/PP interface [polypeptide binding]; other site 882095002477 TPP binding site [chemical binding]; other site 882095002478 substrate binding site [chemical binding]; other site 882095002479 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 882095002480 Domain of unknown function; Region: EKR; smart00890 882095002481 4Fe-4S binding domain; Region: Fer4_6; pfam12837 882095002482 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 882095002483 TPP-binding site [chemical binding]; other site 882095002484 dimer interface [polypeptide binding]; other site 882095002485 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 882095002486 Predicted permeases [General function prediction only]; Region: COG0679 882095002487 Helix-turn-helix domain; Region: HTH_28; pfam13518 882095002488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095002489 non-specific DNA binding site [nucleotide binding]; other site 882095002490 salt bridge; other site 882095002491 sequence-specific DNA binding site [nucleotide binding]; other site 882095002492 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882095002493 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002494 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095002495 Predicted membrane protein [Function unknown]; Region: COG3223 882095002496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095002497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095002498 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882095002499 Walker A/P-loop; other site 882095002500 ATP binding site [chemical binding]; other site 882095002501 Q-loop/lid; other site 882095002502 ABC transporter signature motif; other site 882095002503 Walker B; other site 882095002504 D-loop; other site 882095002505 H-loop/switch region; other site 882095002506 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 882095002507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002508 putative substrate translocation pore; other site 882095002509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095002512 putative substrate translocation pore; other site 882095002513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095002514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095002515 putative DNA binding site [nucleotide binding]; other site 882095002516 putative Zn2+ binding site [ion binding]; other site 882095002517 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882095002518 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882095002519 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095002520 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882095002521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095002522 motif II; other site 882095002523 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882095002524 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002525 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002526 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002527 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002528 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002529 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002530 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095002531 Predicted membrane protein [Function unknown]; Region: COG3326 882095002532 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 882095002533 homotrimer interaction site [polypeptide binding]; other site 882095002534 putative active site [active] 882095002535 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882095002536 substrate binding site [chemical binding]; other site 882095002537 zinc-binding site [ion binding]; other site 882095002538 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882095002539 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882095002540 GIY-YIG motif/motif A; other site 882095002541 active site 882095002542 catalytic site [active] 882095002543 putative DNA binding site [nucleotide binding]; other site 882095002544 metal binding site [ion binding]; metal-binding site 882095002545 UvrB/uvrC motif; Region: UVR; pfam02151 882095002546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882095002547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882095002548 substrate binding pocket [chemical binding]; other site 882095002549 membrane-bound complex binding site; other site 882095002550 hinge residues; other site 882095002551 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882095002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095002553 dimer interface [polypeptide binding]; other site 882095002554 conserved gate region; other site 882095002555 putative PBP binding loops; other site 882095002556 ABC-ATPase subunit interface; other site 882095002557 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882095002558 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882095002559 Walker A/P-loop; other site 882095002560 ATP binding site [chemical binding]; other site 882095002561 Q-loop/lid; other site 882095002562 ABC transporter signature motif; other site 882095002563 Walker B; other site 882095002564 D-loop; other site 882095002565 H-loop/switch region; other site 882095002566 amidase; Provisional; Region: PRK11910 882095002567 Amidase; Region: Amidase; cl11426 882095002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095002570 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882095002571 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882095002572 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 882095002573 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 882095002574 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 882095002575 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 882095002576 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882095002577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882095002578 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 882095002579 Esterase/lipase [General function prediction only]; Region: COG1647 882095002580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095002581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095002582 DNA binding site [nucleotide binding] 882095002583 domain linker motif; other site 882095002584 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 882095002585 putative dimerization interface [polypeptide binding]; other site 882095002586 putative ligand binding site [chemical binding]; other site 882095002587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882095002588 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095002589 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 882095002590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095002591 dimer interface [polypeptide binding]; other site 882095002592 conserved gate region; other site 882095002593 putative PBP binding loops; other site 882095002594 ABC-ATPase subunit interface; other site 882095002595 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095002596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095002597 dimer interface [polypeptide binding]; other site 882095002598 conserved gate region; other site 882095002599 ABC-ATPase subunit interface; other site 882095002600 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882095002601 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882095002602 Ca binding site [ion binding]; other site 882095002603 active site 882095002604 catalytic site [active] 882095002605 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 882095002606 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 882095002607 active site 882095002608 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882095002609 active site 882095002610 substrate binding site [chemical binding]; other site 882095002611 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882095002612 metal binding site [ion binding]; metal-binding site 882095002613 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882095002614 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095002615 ATP binding site [chemical binding]; other site 882095002616 Mg++ binding site [ion binding]; other site 882095002617 motif III; other site 882095002618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095002619 nucleotide binding region [chemical binding]; other site 882095002620 ATP-binding site [chemical binding]; other site 882095002621 Predicted membrane protein [Function unknown]; Region: COG4708 882095002622 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 882095002623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 882095002624 Predicted transcriptional regulators [Transcription]; Region: COG1733 882095002625 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882095002626 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 882095002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002628 putative substrate translocation pore; other site 882095002629 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095002630 PRD domain; Region: PRD; pfam00874 882095002631 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095002632 active site 882095002633 P-loop; other site 882095002634 phosphorylation site [posttranslational modification] 882095002635 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095002636 active site 882095002637 phosphorylation site [posttranslational modification] 882095002638 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095002639 methionine cluster; other site 882095002640 active site 882095002641 phosphorylation site [posttranslational modification] 882095002642 metal binding site [ion binding]; metal-binding site 882095002643 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095002644 active site 882095002645 P-loop; other site 882095002646 phosphorylation site [posttranslational modification] 882095002647 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095002648 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095002649 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882095002650 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882095002651 active site 882095002652 trimer interface [polypeptide binding]; other site 882095002653 allosteric site; other site 882095002654 active site lid [active] 882095002655 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882095002656 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095002657 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095002658 active site 882095002659 catalytic tetrad [active] 882095002660 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882095002661 Collagen binding domain; Region: Collagen_bind; pfam05737 882095002662 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095002663 Uncharacterized conserved protein [Function unknown]; Region: COG3402 882095002664 Predicted membrane protein [Function unknown]; Region: COG3428 882095002665 Bacterial PH domain; Region: DUF304; pfam03703 882095002666 Bacterial PH domain; Region: DUF304; pfam03703 882095002667 Bacterial PH domain; Region: DUF304; pfam03703 882095002668 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 882095002669 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 882095002670 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 882095002671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 882095002672 active site 882095002673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882095002674 dimer interface [polypeptide binding]; other site 882095002675 substrate binding site [chemical binding]; other site 882095002676 catalytic residues [active] 882095002677 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 882095002678 PemK-like protein; Region: PemK; pfam02452 882095002679 Rsbr N terminal; Region: Rsbr_N; pfam08678 882095002680 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882095002681 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882095002682 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882095002683 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 882095002684 ATP binding site [chemical binding]; other site 882095002685 Mg2+ binding site [ion binding]; other site 882095002686 G-X-G motif; other site 882095002687 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 882095002688 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 882095002689 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 882095002690 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 882095002691 anti sigma factor interaction site; other site 882095002692 regulatory phosphorylation site [posttranslational modification]; other site 882095002693 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882095002694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095002695 ATP binding site [chemical binding]; other site 882095002696 Mg2+ binding site [ion binding]; other site 882095002697 G-X-G motif; other site 882095002698 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 882095002699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882095002700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882095002701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882095002702 DNA binding residues [nucleotide binding] 882095002703 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 882095002704 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882095002705 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882095002706 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882095002707 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882095002708 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 882095002709 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 882095002710 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 882095002711 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 882095002712 RNA binding site [nucleotide binding]; other site 882095002713 hypothetical protein; Provisional; Region: PRK04351 882095002714 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 882095002715 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 882095002716 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 882095002717 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882095002718 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095002719 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095002720 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095002721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002722 DNA-binding site [nucleotide binding]; DNA binding site 882095002723 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882095002724 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882095002725 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882095002726 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 882095002727 glutathione reductase; Validated; Region: PRK06116 882095002728 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095002729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095002730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882095002731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095002732 catalytic core [active] 882095002733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882095002734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882095002735 Predicted transcriptional regulators [Transcription]; Region: COG1725 882095002736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002737 DNA-binding site [nucleotide binding]; DNA binding site 882095002738 Predicted membrane protein [General function prediction only]; Region: COG4194 882095002739 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882095002740 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882095002741 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882095002742 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 882095002743 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 882095002744 tetramerization interface [polypeptide binding]; other site 882095002745 NAD(P) binding site [chemical binding]; other site 882095002746 catalytic residues [active] 882095002747 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 882095002748 active site 882095002749 P-loop; other site 882095002750 phosphorylation site [posttranslational modification] 882095002751 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095002752 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095002753 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095002754 methionine cluster; other site 882095002755 active site 882095002756 phosphorylation site [posttranslational modification] 882095002757 metal binding site [ion binding]; metal-binding site 882095002758 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095002759 beta-galactosidase; Region: BGL; TIGR03356 882095002760 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095002761 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095002762 PRD domain; Region: PRD; pfam00874 882095002763 PRD domain; Region: PRD; pfam00874 882095002764 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095002765 active site 882095002766 phosphorylation site [posttranslational modification] 882095002767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095002768 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882095002769 ABC transporter; Region: ABC_tran_2; pfam12848 882095002770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095002771 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 882095002772 Transposase domain (DUF772); Region: DUF772; pfam05598 882095002773 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 882095002774 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 882095002775 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 882095002776 Predicted permeases [General function prediction only]; Region: COG0701 882095002777 Predicted membrane protein [Function unknown]; Region: COG3689 882095002778 pantothenate kinase; Provisional; Region: PRK05439 882095002779 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 882095002780 ATP-binding site [chemical binding]; other site 882095002781 CoA-binding site [chemical binding]; other site 882095002782 Mg2+-binding site [ion binding]; other site 882095002783 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 882095002784 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095002785 Walker A/P-loop; other site 882095002786 ATP binding site [chemical binding]; other site 882095002787 Q-loop/lid; other site 882095002788 ABC transporter signature motif; other site 882095002789 Walker B; other site 882095002790 D-loop; other site 882095002791 H-loop/switch region; other site 882095002792 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882095002793 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882095002794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095002795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095002796 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882095002797 Domain of unknown function (DUF373); Region: DUF373; cl12079 882095002798 Sulfatase; Region: Sulfatase; pfam00884 882095002799 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 882095002800 active site 882095002801 DNA binding site [nucleotide binding] 882095002802 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 882095002803 active site 882095002804 catalytic site [active] 882095002805 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 882095002806 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882095002807 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882095002808 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882095002809 Uncharacterized conserved protein [Function unknown]; Region: COG0398 882095002810 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882095002811 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 882095002812 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 882095002813 epoxyqueuosine reductase; Region: TIGR00276 882095002814 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 882095002815 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 882095002816 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882095002817 dimer interface [polypeptide binding]; other site 882095002818 FMN binding site [chemical binding]; other site 882095002819 NADPH bind site [chemical binding]; other site 882095002820 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882095002821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882095002822 active site 882095002823 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882095002824 HSP90 family protein; Provisional; Region: PRK14083 882095002825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095002826 ATP binding site [chemical binding]; other site 882095002827 Mg2+ binding site [ion binding]; other site 882095002828 G-X-G motif; other site 882095002829 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 882095002830 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 882095002831 dimerization interface [polypeptide binding]; other site 882095002832 DPS ferroxidase diiron center [ion binding]; other site 882095002833 ion pore; other site 882095002834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 882095002835 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882095002836 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095002837 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 882095002838 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 882095002839 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 882095002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002841 putative substrate translocation pore; other site 882095002842 Transcriptional regulators [Transcription]; Region: FadR; COG2186 882095002843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002844 DNA-binding site [nucleotide binding]; DNA binding site 882095002845 FCD domain; Region: FCD; pfam07729 882095002846 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882095002847 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882095002848 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882095002849 PGAP1-like protein; Region: PGAP1; pfam07819 882095002850 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882095002851 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 882095002852 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 882095002853 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 882095002854 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882095002855 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882095002856 active site 882095002857 dimer interface [polypeptide binding]; other site 882095002858 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882095002859 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882095002860 active site 882095002861 trimer interface [polypeptide binding]; other site 882095002862 allosteric site; other site 882095002863 active site lid [active] 882095002864 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882095002865 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095002866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095002867 DNA-binding site [nucleotide binding]; DNA binding site 882095002868 UTRA domain; Region: UTRA; pfam07702 882095002869 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882095002870 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882095002871 Mg++ binding site [ion binding]; other site 882095002872 putative catalytic motif [active] 882095002873 substrate binding site [chemical binding]; other site 882095002874 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882095002875 Peptidase family U32; Region: Peptidase_U32; pfam01136 882095002876 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882095002877 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882095002878 Peptidase family U32; Region: Peptidase_U32; pfam01136 882095002879 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 882095002880 heat shock protein HtpX; Provisional; Region: PRK04897 882095002881 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 882095002882 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 882095002883 catalytic residues [active] 882095002884 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 882095002885 putative active site [active] 882095002886 putative metal binding residues [ion binding]; other site 882095002887 signature motif; other site 882095002888 putative triphosphate binding site [ion binding]; other site 882095002889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095002890 TPR motif; other site 882095002891 binding surface 882095002892 Tetratrico peptide repeat; Region: TPR_5; pfam12688 882095002893 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882095002894 synthetase active site [active] 882095002895 NTP binding site [chemical binding]; other site 882095002896 metal binding site [ion binding]; metal-binding site 882095002897 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 882095002898 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882095002899 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882095002900 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882095002901 active site 882095002902 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 882095002903 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 882095002904 NAD binding site [chemical binding]; other site 882095002905 homotetramer interface [polypeptide binding]; other site 882095002906 homodimer interface [polypeptide binding]; other site 882095002907 substrate binding site [chemical binding]; other site 882095002908 active site 882095002909 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 882095002910 DltD N-terminal region; Region: DltD_N; pfam04915 882095002911 DltD central region; Region: DltD_M; pfam04918 882095002912 DltD C-terminal region; Region: DltD_C; pfam04914 882095002913 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 882095002914 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 882095002915 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 882095002916 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 882095002917 acyl-activating enzyme (AAE) consensus motif; other site 882095002918 AMP binding site [chemical binding]; other site 882095002919 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 882095002920 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 882095002921 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095002922 active site 882095002923 dimer interface [polypeptide binding]; other site 882095002924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095002925 Coenzyme A binding pocket [chemical binding]; other site 882095002926 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 882095002927 Putative esterase; Region: Esterase; pfam00756 882095002928 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 882095002929 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 882095002930 homodimer interface [polypeptide binding]; other site 882095002931 substrate-cofactor binding pocket; other site 882095002932 catalytic residue [active] 882095002933 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882095002934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095002935 Walker A/P-loop; other site 882095002936 ATP binding site [chemical binding]; other site 882095002937 Q-loop/lid; other site 882095002938 ABC transporter signature motif; other site 882095002939 Walker B; other site 882095002940 D-loop; other site 882095002941 H-loop/switch region; other site 882095002942 ABC-2 type transporter; Region: ABC2_membrane; cl17235 882095002943 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882095002944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095002945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095002946 putative substrate translocation pore; other site 882095002947 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882095002948 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 882095002949 putative oligomer interface [polypeptide binding]; other site 882095002950 putative active site [active] 882095002951 metal binding site [ion binding]; metal-binding site 882095002952 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 882095002953 catalytic residues [active] 882095002954 dimer interface [polypeptide binding]; other site 882095002955 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882095002956 LytTr DNA-binding domain; Region: LytTR; pfam04397 882095002957 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095002958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095002959 Walker A/P-loop; other site 882095002960 ATP binding site [chemical binding]; other site 882095002961 Q-loop/lid; other site 882095002962 ABC transporter signature motif; other site 882095002963 Walker B; other site 882095002964 D-loop; other site 882095002965 H-loop/switch region; other site 882095002966 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 882095002967 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 882095002968 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882095002969 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 882095002970 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 882095002971 G1 box; other site 882095002972 putative GEF interaction site [polypeptide binding]; other site 882095002973 GTP/Mg2+ binding site [chemical binding]; other site 882095002974 Switch I region; other site 882095002975 G2 box; other site 882095002976 G3 box; other site 882095002977 Switch II region; other site 882095002978 G4 box; other site 882095002979 G5 box; other site 882095002980 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 882095002981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095002982 MarR family; Region: MarR_2; cl17246 882095002983 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882095002984 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882095002985 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882095002986 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882095002987 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 882095002988 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 882095002989 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 882095002990 Acyltransferase family; Region: Acyl_transf_3; pfam01757 882095002991 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 882095002992 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882095002993 DNA binding site [nucleotide binding] 882095002994 active site 882095002995 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 882095002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095002997 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 882095002998 Walker A motif; other site 882095002999 ATP binding site [chemical binding]; other site 882095003000 Walker B motif; other site 882095003001 arginine finger; other site 882095003002 UvrB/uvrC motif; Region: UVR; pfam02151 882095003003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095003004 Walker A motif; other site 882095003005 ATP binding site [chemical binding]; other site 882095003006 Walker B motif; other site 882095003007 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882095003008 CAAX protease self-immunity; Region: Abi; pfam02517 882095003009 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 882095003010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882095003011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 882095003012 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 882095003013 dimerization domain swap beta strand [polypeptide binding]; other site 882095003014 regulatory protein interface [polypeptide binding]; other site 882095003015 active site 882095003016 regulatory phosphorylation site [posttranslational modification]; other site 882095003017 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 882095003018 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 882095003019 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882095003020 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882095003021 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882095003022 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882095003023 putative active site [active] 882095003024 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 882095003025 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882095003026 aminotransferase A; Validated; Region: PRK07683 882095003027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095003028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095003029 homodimer interface [polypeptide binding]; other site 882095003030 catalytic residue [active] 882095003031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 882095003032 FOG: CBS domain [General function prediction only]; Region: COG0517 882095003033 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 882095003034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095003035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095003036 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882095003037 dimerization interface [polypeptide binding]; other site 882095003038 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 882095003039 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 882095003040 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882095003041 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882095003042 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882095003043 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 882095003044 metal binding site [ion binding]; metal-binding site 882095003045 putative dimer interface [polypeptide binding]; other site 882095003046 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 882095003047 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 882095003048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 882095003049 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 882095003050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095003051 Walker A/P-loop; other site 882095003052 ATP binding site [chemical binding]; other site 882095003053 Q-loop/lid; other site 882095003054 ABC transporter signature motif; other site 882095003055 Walker B; other site 882095003056 D-loop; other site 882095003057 H-loop/switch region; other site 882095003058 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882095003059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095003060 dimer interface [polypeptide binding]; other site 882095003061 conserved gate region; other site 882095003062 putative PBP binding loops; other site 882095003063 ABC-ATPase subunit interface; other site 882095003064 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 882095003065 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882095003066 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882095003067 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 882095003068 HPr interaction site; other site 882095003069 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882095003070 active site 882095003071 phosphorylation site [posttranslational modification] 882095003072 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882095003073 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 882095003074 S1 domain; Region: S1_2; pfam13509 882095003075 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 882095003076 RNA binding site [nucleotide binding]; other site 882095003077 Predicted membrane protein [Function unknown]; Region: COG4758 882095003078 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 882095003079 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 882095003080 Histidine kinase; Region: HisKA_3; pfam07730 882095003081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095003082 ATP binding site [chemical binding]; other site 882095003083 Mg2+ binding site [ion binding]; other site 882095003084 G-X-G motif; other site 882095003085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882095003086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095003087 active site 882095003088 phosphorylation site [posttranslational modification] 882095003089 intermolecular recognition site; other site 882095003090 dimerization interface [polypeptide binding]; other site 882095003091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882095003092 DNA binding residues [nucleotide binding] 882095003093 dimerization interface [polypeptide binding]; other site 882095003094 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 882095003095 TrkA-N domain; Region: TrkA_N; pfam02254 882095003096 TrkA-C domain; Region: TrkA_C; pfam02080 882095003097 Predicted membrane protein [Function unknown]; Region: COG1289 882095003098 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 882095003099 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 882095003100 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882095003101 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882095003102 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882095003103 hypothetical protein; Provisional; Region: PRK13667 882095003104 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095003105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095003106 active site 882095003107 motif I; other site 882095003108 motif II; other site 882095003109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095003110 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095003111 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095003112 DNA binding site [nucleotide binding] 882095003113 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882095003114 ligand binding site [chemical binding]; other site 882095003115 dimerization interface [polypeptide binding]; other site 882095003116 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 882095003117 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882095003118 trimer interface [polypeptide binding]; other site 882095003119 substrate binding site [chemical binding]; other site 882095003120 Mn binding site [ion binding]; other site 882095003121 transketolase; Reviewed; Region: PRK05899 882095003122 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882095003123 TPP-binding site [chemical binding]; other site 882095003124 dimer interface [polypeptide binding]; other site 882095003125 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 882095003126 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882095003127 PYR/PP interface [polypeptide binding]; other site 882095003128 dimer interface [polypeptide binding]; other site 882095003129 TPP binding site [chemical binding]; other site 882095003130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095003131 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 882095003132 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 882095003133 N- and C-terminal domain interface [polypeptide binding]; other site 882095003134 active site 882095003135 MgATP binding site [chemical binding]; other site 882095003136 catalytic site [active] 882095003137 metal binding site [ion binding]; metal-binding site 882095003138 putative glycerol binding site [chemical binding]; other site 882095003139 putative homotetramer interface [polypeptide binding]; other site 882095003140 putative homodimer interface [polypeptide binding]; other site 882095003141 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882095003142 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882095003143 active site turn [active] 882095003144 phosphorylation site [posttranslational modification] 882095003145 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882095003146 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882095003147 HPr interaction site; other site 882095003148 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882095003149 active site 882095003150 phosphorylation site [posttranslational modification] 882095003151 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 882095003152 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 882095003153 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 882095003154 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 882095003155 GTP binding site; other site 882095003156 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 882095003157 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882095003158 Walker A/P-loop; other site 882095003159 ATP binding site [chemical binding]; other site 882095003160 Q-loop/lid; other site 882095003161 ABC transporter signature motif; other site 882095003162 Walker B; other site 882095003163 D-loop; other site 882095003164 H-loop/switch region; other site 882095003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095003166 dimer interface [polypeptide binding]; other site 882095003167 conserved gate region; other site 882095003168 putative PBP binding loops; other site 882095003169 ABC-ATPase subunit interface; other site 882095003170 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 882095003171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 882095003172 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 882095003173 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 882095003174 dimer interface [polypeptide binding]; other site 882095003175 putative functional site; other site 882095003176 putative MPT binding site; other site 882095003177 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 882095003178 Walker A motif; other site 882095003179 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 882095003180 MoaE homodimer interface [polypeptide binding]; other site 882095003181 MoaD interaction [polypeptide binding]; other site 882095003182 active site residues [active] 882095003183 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 882095003184 MoaE interaction surface [polypeptide binding]; other site 882095003185 MoeB interaction surface [polypeptide binding]; other site 882095003186 thiocarboxylated glycine; other site 882095003187 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 882095003188 trimer interface [polypeptide binding]; other site 882095003189 dimer interface [polypeptide binding]; other site 882095003190 putative active site [active] 882095003191 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 882095003192 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882095003193 FeS/SAM binding site; other site 882095003194 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 882095003195 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 882095003196 MPT binding site; other site 882095003197 trimer interface [polypeptide binding]; other site 882095003198 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 882095003199 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 882095003200 ATP binding site [chemical binding]; other site 882095003201 substrate interface [chemical binding]; other site 882095003202 Flavin Reductases; Region: FlaRed; cl00801 882095003203 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 882095003204 active site 882095003205 catalytic residues [active] 882095003206 metal binding site [ion binding]; metal-binding site 882095003207 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 882095003208 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882095003209 TPP-binding site [chemical binding]; other site 882095003210 tetramer interface [polypeptide binding]; other site 882095003211 heterodimer interface [polypeptide binding]; other site 882095003212 phosphorylation loop region [posttranslational modification] 882095003213 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882095003214 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882095003215 alpha subunit interface [polypeptide binding]; other site 882095003216 TPP binding site [chemical binding]; other site 882095003217 heterodimer interface [polypeptide binding]; other site 882095003218 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095003219 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 882095003220 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882095003221 E3 interaction surface; other site 882095003222 lipoyl attachment site [posttranslational modification]; other site 882095003223 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882095003224 E3 interaction surface; other site 882095003225 lipoyl attachment site [posttranslational modification]; other site 882095003226 e3 binding domain; Region: E3_binding; pfam02817 882095003227 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882095003228 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 882095003229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882095003230 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095003231 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882095003232 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 882095003233 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 882095003234 NAD(P) binding site [chemical binding]; other site 882095003235 LDH/MDH dimer interface [polypeptide binding]; other site 882095003236 substrate binding site [chemical binding]; other site 882095003237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 882095003238 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 882095003239 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 882095003240 catalytic residues [active] 882095003241 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882095003242 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882095003243 Cl binding site [ion binding]; other site 882095003244 oligomer interface [polypeptide binding]; other site 882095003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 882095003246 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 882095003247 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 882095003248 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 882095003249 active site 882095003250 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 882095003251 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 882095003252 G1 box; other site 882095003253 putative GEF interaction site [polypeptide binding]; other site 882095003254 GTP/Mg2+ binding site [chemical binding]; other site 882095003255 Switch I region; other site 882095003256 G2 box; other site 882095003257 G3 box; other site 882095003258 Switch II region; other site 882095003259 G4 box; other site 882095003260 G5 box; other site 882095003261 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 882095003262 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 882095003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 882095003264 hypothetical protein; Provisional; Region: PRK13666 882095003265 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882095003266 pyruvate carboxylase; Reviewed; Region: PRK12999 882095003267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882095003268 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882095003269 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882095003270 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 882095003271 active site 882095003272 catalytic residues [active] 882095003273 metal binding site [ion binding]; metal-binding site 882095003274 homodimer binding site [polypeptide binding]; other site 882095003275 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882095003276 carboxyltransferase (CT) interaction site; other site 882095003277 biotinylation site [posttranslational modification]; other site 882095003278 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 882095003279 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882095003280 putative binding site residues; other site 882095003281 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 882095003282 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882095003283 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 882095003284 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 882095003285 Walker A/P-loop; other site 882095003286 ATP binding site [chemical binding]; other site 882095003287 Q-loop/lid; other site 882095003288 ABC transporter signature motif; other site 882095003289 Walker B; other site 882095003290 D-loop; other site 882095003291 H-loop/switch region; other site 882095003292 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095003293 SH3-like domain; Region: SH3_8; pfam13457 882095003294 SH3-like domain; Region: SH3_8; pfam13457 882095003295 SH3-like domain; Region: SH3_8; pfam13457 882095003296 SH3-like domain; Region: SH3_8; pfam13457 882095003297 SH3-like domain; Region: SH3_8; pfam13457 882095003298 SH3-like domain; Region: SH3_8; pfam13457 882095003299 SH3-like domain; Region: SH3_8; pfam13457 882095003300 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 882095003301 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 882095003302 Ligand binding site; other site 882095003303 Putative Catalytic site; other site 882095003304 DXD motif; other site 882095003305 conserved hypothetical integral membrane protein; Region: TIGR03766 882095003306 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 882095003307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882095003308 active site 882095003309 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882095003310 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882095003311 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 882095003312 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 882095003313 active site 882095003314 tetramer interface; other site 882095003315 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882095003316 substrate binding site; other site 882095003317 dimer interface; other site 882095003318 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 882095003319 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882095003320 putative NAD(P) binding site [chemical binding]; other site 882095003321 putative catalytic Zn binding site [ion binding]; other site 882095003322 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882095003323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882095003324 active site 882095003325 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882095003326 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882095003327 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882095003328 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 882095003329 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 882095003330 active site 882095003331 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 882095003332 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 882095003333 active site 882095003334 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 882095003335 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 882095003336 homodimer interface [polypeptide binding]; other site 882095003337 NAD binding pocket [chemical binding]; other site 882095003338 ATP binding pocket [chemical binding]; other site 882095003339 Mg binding site [ion binding]; other site 882095003340 active-site loop [active] 882095003341 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882095003342 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 882095003343 active site 882095003344 P-loop; other site 882095003345 phosphorylation site [posttranslational modification] 882095003346 GMP synthase; Reviewed; Region: guaA; PRK00074 882095003347 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 882095003348 AMP/PPi binding site [chemical binding]; other site 882095003349 candidate oxyanion hole; other site 882095003350 catalytic triad [active] 882095003351 potential glutamine specificity residues [chemical binding]; other site 882095003352 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 882095003353 ATP Binding subdomain [chemical binding]; other site 882095003354 Dimerization subdomain; other site 882095003355 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 882095003356 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095003357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095003358 ATP binding site [chemical binding]; other site 882095003359 putative Mg++ binding site [ion binding]; other site 882095003360 T5orf172 domain; Region: T5orf172; pfam10544 882095003361 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 882095003362 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 882095003363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882095003364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882095003365 MepB protein; Region: MepB; cl01985 882095003366 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 882095003367 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095003368 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095003369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095003370 Coenzyme A binding pocket [chemical binding]; other site 882095003371 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095003372 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 882095003373 DNA binding residues [nucleotide binding] 882095003374 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882095003375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095003376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095003377 Walker A/P-loop; other site 882095003378 ATP binding site [chemical binding]; other site 882095003379 Q-loop/lid; other site 882095003380 ABC transporter signature motif; other site 882095003381 Walker B; other site 882095003382 D-loop; other site 882095003383 H-loop/switch region; other site 882095003384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095003385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095003386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095003387 Walker A/P-loop; other site 882095003388 ATP binding site [chemical binding]; other site 882095003389 Q-loop/lid; other site 882095003390 ABC transporter signature motif; other site 882095003391 Walker B; other site 882095003392 D-loop; other site 882095003393 H-loop/switch region; other site 882095003394 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882095003395 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095003396 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095003397 DNA binding residues [nucleotide binding] 882095003398 putative dimer interface [polypeptide binding]; other site 882095003399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882095003400 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 882095003401 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095003402 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095003403 LRR adjacent; Region: LRR_adjacent; pfam08191 882095003404 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 882095003406 Clp protease; Region: CLP_protease; pfam00574 882095003407 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882095003408 oligomer interface [polypeptide binding]; other site 882095003409 active site residues [active] 882095003410 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882095003411 dimer interface [polypeptide binding]; other site 882095003412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095003413 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 882095003414 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 882095003415 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 882095003416 SLBB domain; Region: SLBB; pfam10531 882095003417 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 882095003418 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 882095003419 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003420 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882095003421 putative hexamer interface [polypeptide binding]; other site 882095003422 putative hexagonal pore; other site 882095003423 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882095003424 putative hexamer interface [polypeptide binding]; other site 882095003425 putative hexagonal pore; other site 882095003426 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 882095003427 putative hexamer interface [polypeptide binding]; other site 882095003428 putative hexagonal pore; other site 882095003429 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 882095003430 G1 box; other site 882095003431 GTP/Mg2+ binding site [chemical binding]; other site 882095003432 G2 box; other site 882095003433 Switch I region; other site 882095003434 G3 box; other site 882095003435 Switch II region; other site 882095003436 G4 box; other site 882095003437 G5 box; other site 882095003438 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 882095003439 homotrimer interface [polypeptide binding]; other site 882095003440 Walker A motif; other site 882095003441 GTP binding site [chemical binding]; other site 882095003442 Walker B motif; other site 882095003443 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 882095003444 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095003445 catalytic core [active] 882095003446 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 882095003447 Sensory domain found in PocR; Region: PocR; pfam10114 882095003448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095003449 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095003450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095003451 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003452 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882095003453 Hexamer interface [polypeptide binding]; other site 882095003454 Hexagonal pore residue; other site 882095003455 propanediol utilization protein PduB; Provisional; Region: PRK15415 882095003456 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 882095003457 putative hexamer interface [polypeptide binding]; other site 882095003458 putative hexagonal pore; other site 882095003459 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 882095003460 putative hexamer interface [polypeptide binding]; other site 882095003461 putative hexagonal pore; other site 882095003462 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 882095003463 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 882095003464 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 882095003465 alpha-beta subunit interface [polypeptide binding]; other site 882095003466 alpha-gamma subunit interface [polypeptide binding]; other site 882095003467 active site 882095003468 substrate and K+ binding site; other site 882095003469 K+ binding site [ion binding]; other site 882095003470 cobalamin binding site [chemical binding]; other site 882095003471 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 882095003472 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 882095003473 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 882095003474 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 882095003475 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003476 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 882095003477 putative hexamer interface [polypeptide binding]; other site 882095003478 putative hexagonal pore; other site 882095003479 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003480 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882095003481 Hexamer interface [polypeptide binding]; other site 882095003482 Hexagonal pore residue; other site 882095003483 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882095003484 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882095003485 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882095003486 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 882095003487 Cell division protein FtsA; Region: FtsA; cl17206 882095003488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882095003489 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 882095003490 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882095003491 Hexamer/Pentamer interface [polypeptide binding]; other site 882095003492 central pore; other site 882095003493 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882095003494 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 882095003495 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 882095003496 putative catalytic cysteine [active] 882095003497 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882095003498 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882095003499 putative active site [active] 882095003500 metal binding site [ion binding]; metal-binding site 882095003501 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882095003502 amphipathic channel; other site 882095003503 Asn-Pro-Ala signature motifs; other site 882095003504 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882095003505 propionate/acetate kinase; Provisional; Region: PRK12379 882095003506 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 882095003507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095003508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095003509 homodimer interface [polypeptide binding]; other site 882095003510 catalytic residue [active] 882095003511 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 882095003512 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882095003513 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882095003514 putative active site [active] 882095003515 metal binding site [ion binding]; metal-binding site 882095003516 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 882095003517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095003518 active site 882095003519 phosphorylation site [posttranslational modification] 882095003520 intermolecular recognition site; other site 882095003521 dimerization interface [polypeptide binding]; other site 882095003522 ANTAR domain; Region: ANTAR; pfam03861 882095003523 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 882095003524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 882095003525 Histidine kinase; Region: HisKA_2; pfam07568 882095003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095003527 ATP binding site [chemical binding]; other site 882095003528 Mg2+ binding site [ion binding]; other site 882095003529 G-X-G motif; other site 882095003530 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 882095003531 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 882095003532 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 882095003533 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 882095003534 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 882095003535 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 882095003536 putative hexamer interface [polypeptide binding]; other site 882095003537 putative hexagonal pore; other site 882095003538 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 882095003539 putative hexamer interface [polypeptide binding]; other site 882095003540 putative hexagonal pore; other site 882095003541 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003542 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882095003543 Hexamer interface [polypeptide binding]; other site 882095003544 Hexagonal pore residue; other site 882095003545 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882095003546 putative catalytic cysteine [active] 882095003547 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882095003548 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 882095003549 Hexamer interface [polypeptide binding]; other site 882095003550 Putative hexagonal pore residue; other site 882095003551 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 882095003552 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882095003553 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882095003554 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882095003555 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 882095003556 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882095003557 Hexamer/Pentamer interface [polypeptide binding]; other site 882095003558 central pore; other site 882095003559 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 882095003560 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882095003561 putative hexamer interface [polypeptide binding]; other site 882095003562 putative hexagonal pore; other site 882095003563 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882095003564 putative hexamer interface [polypeptide binding]; other site 882095003565 putative hexagonal pore; other site 882095003566 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 882095003567 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 882095003568 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 882095003569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095003570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095003571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095003572 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 882095003573 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882095003574 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 882095003575 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 882095003576 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 882095003577 catalytic triad [active] 882095003578 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 882095003579 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 882095003580 Precorrin-8X methylmutase; Region: CbiC; pfam02570 882095003581 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 882095003582 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 882095003583 active site 882095003584 putative homodimer interface [polypeptide binding]; other site 882095003585 SAM binding site [chemical binding]; other site 882095003586 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 882095003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095003588 S-adenosylmethionine binding site [chemical binding]; other site 882095003589 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 882095003590 active site 882095003591 SAM binding site [chemical binding]; other site 882095003592 homodimer interface [polypeptide binding]; other site 882095003593 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 882095003594 active site 882095003595 SAM binding site [chemical binding]; other site 882095003596 homodimer interface [polypeptide binding]; other site 882095003597 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 882095003598 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 882095003599 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 882095003600 active site 882095003601 SAM binding site [chemical binding]; other site 882095003602 homodimer interface [polypeptide binding]; other site 882095003603 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 882095003604 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882095003605 active site 882095003606 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 882095003607 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 882095003608 active site 882095003609 C-terminal domain interface [polypeptide binding]; other site 882095003610 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 882095003611 active site 882095003612 N-terminal domain interface [polypeptide binding]; other site 882095003613 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 882095003614 active site 882095003615 SAM binding site [chemical binding]; other site 882095003616 homodimer interface [polypeptide binding]; other site 882095003617 cobalt transport protein CbiM; Validated; Region: PRK08319 882095003618 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 882095003619 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 882095003620 cobalt transport protein CbiQ; Provisional; Region: PRK15485 882095003621 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 882095003622 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882095003623 Walker A/P-loop; other site 882095003624 ATP binding site [chemical binding]; other site 882095003625 Q-loop/lid; other site 882095003626 ABC transporter signature motif; other site 882095003627 Walker B; other site 882095003628 D-loop; other site 882095003629 H-loop/switch region; other site 882095003630 cobyric acid synthase; Provisional; Region: PRK00784 882095003631 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882095003632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882095003633 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 882095003634 catalytic triad [active] 882095003635 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882095003636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882095003637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882095003638 AAA domain; Region: AAA_17; cl17253 882095003639 Predicted transcriptional regulators [Transcription]; Region: COG1695 882095003640 Transcriptional regulator PadR-like family; Region: PadR; cl17335 882095003641 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 882095003642 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095003643 SH3-like domain; Region: SH3_8; pfam13457 882095003644 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095003645 SH3-like domain; Region: SH3_8; pfam13457 882095003646 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882095003647 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882095003648 oligomer interface [polypeptide binding]; other site 882095003649 active site 882095003650 metal binding site [ion binding]; metal-binding site 882095003651 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882095003652 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 882095003653 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882095003654 Predicted transcriptional regulators [Transcription]; Region: COG1733 882095003655 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882095003656 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 882095003657 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 882095003658 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 882095003659 dimer interface [polypeptide binding]; other site 882095003660 motif 1; other site 882095003661 active site 882095003662 motif 2; other site 882095003663 motif 3; other site 882095003664 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 882095003665 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882095003666 putative tRNA-binding site [nucleotide binding]; other site 882095003667 B3/4 domain; Region: B3_4; pfam03483 882095003668 tRNA synthetase B5 domain; Region: B5; smart00874 882095003669 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 882095003670 dimer interface [polypeptide binding]; other site 882095003671 motif 1; other site 882095003672 motif 3; other site 882095003673 motif 2; other site 882095003674 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 882095003675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095003676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095003677 Walker A/P-loop; other site 882095003678 ATP binding site [chemical binding]; other site 882095003679 Q-loop/lid; other site 882095003680 ABC transporter signature motif; other site 882095003681 Walker B; other site 882095003682 D-loop; other site 882095003683 H-loop/switch region; other site 882095003684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095003685 FtsX-like permease family; Region: FtsX; pfam02687 882095003686 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882095003687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095003688 FtsX-like permease family; Region: FtsX; pfam02687 882095003689 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882095003690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095003691 putative DNA binding site [nucleotide binding]; other site 882095003692 putative Zn2+ binding site [ion binding]; other site 882095003693 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 882095003694 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882095003695 ligand binding site [chemical binding]; other site 882095003696 active site 882095003697 UGI interface [polypeptide binding]; other site 882095003698 catalytic site [active] 882095003699 ribonuclease HIII; Provisional; Region: PRK00996 882095003700 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 882095003701 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 882095003702 RNA/DNA hybrid binding site [nucleotide binding]; other site 882095003703 active site 882095003704 Cell division protein ZapA; Region: ZapA; cl01146 882095003705 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 882095003706 Colicin V production protein; Region: Colicin_V; pfam02674 882095003707 hypothetical protein; Provisional; Region: PRK08609 882095003708 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 882095003709 active site 882095003710 primer binding site [nucleotide binding]; other site 882095003711 NTP binding site [chemical binding]; other site 882095003712 metal binding triad [ion binding]; metal-binding site 882095003713 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 882095003714 active site 882095003715 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 882095003716 MutS domain III; Region: MutS_III; pfam05192 882095003717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095003718 Walker A/P-loop; other site 882095003719 ATP binding site [chemical binding]; other site 882095003720 Q-loop/lid; other site 882095003721 ABC transporter signature motif; other site 882095003722 Walker B; other site 882095003723 D-loop; other site 882095003724 H-loop/switch region; other site 882095003725 Smr domain; Region: Smr; pfam01713 882095003726 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095003727 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882095003728 catalytic residues [active] 882095003729 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882095003730 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882095003731 GIY-YIG motif/motif A; other site 882095003732 active site 882095003733 catalytic site [active] 882095003734 putative DNA binding site [nucleotide binding]; other site 882095003735 metal binding site [ion binding]; metal-binding site 882095003736 UvrB/uvrC motif; Region: UVR; pfam02151 882095003737 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 882095003738 aspartate kinase; Reviewed; Region: PRK06635 882095003739 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 882095003740 putative nucleotide binding site [chemical binding]; other site 882095003741 putative catalytic residues [active] 882095003742 putative Mg ion binding site [ion binding]; other site 882095003743 putative aspartate binding site [chemical binding]; other site 882095003744 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 882095003745 putative allosteric regulatory site; other site 882095003746 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 882095003747 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 882095003748 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 882095003749 ribonuclease PH; Reviewed; Region: rph; PRK00173 882095003750 Ribonuclease PH; Region: RNase_PH_bact; cd11362 882095003751 hexamer interface [polypeptide binding]; other site 882095003752 active site 882095003753 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 882095003754 active site 882095003755 dimerization interface [polypeptide binding]; other site 882095003756 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 882095003757 active site 882095003758 metal binding site [ion binding]; metal-binding site 882095003759 homotetramer interface [polypeptide binding]; other site 882095003760 Leucine rich repeat; Region: LRR_8; pfam13855 882095003761 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095003762 LRR adjacent; Region: LRR_adjacent; pfam08191 882095003763 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095003764 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095003765 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095003766 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095003767 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095003768 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882095003769 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882095003770 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 882095003771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 882095003772 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 882095003773 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882095003774 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882095003775 dimer interface [polypeptide binding]; other site 882095003776 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095003777 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095003778 catalytic core [active] 882095003779 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 882095003780 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882095003781 ATP binding site [chemical binding]; other site 882095003782 Mg++ binding site [ion binding]; other site 882095003783 motif III; other site 882095003784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095003785 nucleotide binding region [chemical binding]; other site 882095003786 ATP-binding site [chemical binding]; other site 882095003787 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 882095003788 RNA binding site [nucleotide binding]; other site 882095003789 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882095003790 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 882095003791 putative active site [active] 882095003792 nucleotide binding site [chemical binding]; other site 882095003793 nudix motif; other site 882095003794 putative metal binding site [ion binding]; other site 882095003795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095003796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095003797 putative substrate translocation pore; other site 882095003798 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095003799 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095003800 ligand binding site [chemical binding]; other site 882095003801 flexible hinge region; other site 882095003802 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095003803 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882095003804 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095003805 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095003806 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 882095003807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095003808 DNA-binding site [nucleotide binding]; DNA binding site 882095003809 UTRA domain; Region: UTRA; pfam07702 882095003810 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882095003811 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882095003812 Ca binding site [ion binding]; other site 882095003813 active site 882095003814 catalytic site [active] 882095003815 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882095003816 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 882095003817 active site turn [active] 882095003818 phosphorylation site [posttranslational modification] 882095003819 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882095003820 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 882095003821 nudix motif; other site 882095003822 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 882095003823 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095003824 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 882095003825 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 882095003826 putative catalytic cysteine [active] 882095003827 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 882095003828 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 882095003829 nucleotide binding site [chemical binding]; other site 882095003830 homotetrameric interface [polypeptide binding]; other site 882095003831 putative phosphate binding site [ion binding]; other site 882095003832 putative allosteric binding site; other site 882095003833 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 882095003834 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 882095003835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882095003836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095003837 non-specific DNA binding site [nucleotide binding]; other site 882095003838 salt bridge; other site 882095003839 sequence-specific DNA binding site [nucleotide binding]; other site 882095003840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095003841 non-specific DNA binding site [nucleotide binding]; other site 882095003842 salt bridge; other site 882095003843 sequence-specific DNA binding site [nucleotide binding]; other site 882095003844 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882095003845 active site 882095003846 trigger factor; Provisional; Region: tig; PRK01490 882095003847 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 882095003848 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 882095003849 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 882095003850 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 882095003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095003852 Walker A motif; other site 882095003853 ATP binding site [chemical binding]; other site 882095003854 Walker B motif; other site 882095003855 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882095003856 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882095003857 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882095003858 Catalytic site [active] 882095003859 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882095003860 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882095003861 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882095003862 Catalytic site [active] 882095003863 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 882095003864 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 882095003865 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882095003866 Catalytic site [active] 882095003867 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882095003868 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 882095003869 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 882095003870 GTP/Mg2+ binding site [chemical binding]; other site 882095003871 G4 box; other site 882095003872 G5 box; other site 882095003873 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 882095003874 G1 box; other site 882095003875 G1 box; other site 882095003876 GTP/Mg2+ binding site [chemical binding]; other site 882095003877 Switch I region; other site 882095003878 G2 box; other site 882095003879 G2 box; other site 882095003880 G3 box; other site 882095003881 G3 box; other site 882095003882 Switch II region; other site 882095003883 Switch II region; other site 882095003884 G5 box; other site 882095003885 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 882095003886 RNA/DNA hybrid binding site [nucleotide binding]; other site 882095003887 active site 882095003888 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 882095003889 DNA protecting protein DprA; Region: dprA; TIGR00732 882095003890 DNA topoisomerase I; Validated; Region: PRK05582 882095003891 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 882095003892 active site 882095003893 interdomain interaction site; other site 882095003894 putative metal-binding site [ion binding]; other site 882095003895 nucleotide binding site [chemical binding]; other site 882095003896 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882095003897 domain I; other site 882095003898 DNA binding groove [nucleotide binding] 882095003899 phosphate binding site [ion binding]; other site 882095003900 domain II; other site 882095003901 domain III; other site 882095003902 nucleotide binding site [chemical binding]; other site 882095003903 catalytic site [active] 882095003904 domain IV; other site 882095003905 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882095003906 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882095003907 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882095003908 Glucose inhibited division protein A; Region: GIDA; pfam01134 882095003909 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 882095003910 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 882095003911 active site 882095003912 DNA binding site [nucleotide binding] 882095003913 Int/Topo IB signature motif; other site 882095003914 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 882095003915 active site 882095003916 HslU subunit interaction site [polypeptide binding]; other site 882095003917 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 882095003918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095003919 Walker A motif; other site 882095003920 ATP binding site [chemical binding]; other site 882095003921 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 882095003922 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882095003923 transcriptional repressor CodY; Validated; Region: PRK04158 882095003924 CodY GAF-like domain; Region: CodY; pfam06018 882095003925 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 882095003926 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 882095003927 active site 882095003928 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 882095003929 active site 882095003930 catalytic residues [active] 882095003931 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 882095003932 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 882095003933 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 882095003934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095003935 Mg2+ binding site [ion binding]; other site 882095003936 G-X-G motif; other site 882095003937 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882095003938 anchoring element; other site 882095003939 dimer interface [polypeptide binding]; other site 882095003940 ATP binding site [chemical binding]; other site 882095003941 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882095003942 active site 882095003943 putative metal-binding site [ion binding]; other site 882095003944 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882095003945 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 882095003946 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882095003947 CAP-like domain; other site 882095003948 active site 882095003949 primary dimer interface [polypeptide binding]; other site 882095003950 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882095003951 S-ribosylhomocysteinase; Provisional; Region: PRK02260 882095003952 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882095003953 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095003954 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 882095003955 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 882095003956 catalytic triad [active] 882095003957 catalytic triad [active] 882095003958 oxyanion hole [active] 882095003959 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882095003960 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 882095003961 active site 882095003962 catalytic site [active] 882095003963 metal binding site [ion binding]; metal-binding site 882095003964 dimer interface [polypeptide binding]; other site 882095003965 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 882095003966 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 882095003967 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 882095003968 bacterial Hfq-like; Region: Hfq; cd01716 882095003969 hexamer interface [polypeptide binding]; other site 882095003970 Sm1 motif; other site 882095003971 RNA binding site [nucleotide binding]; other site 882095003972 Sm2 motif; other site 882095003973 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 882095003974 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882095003975 HflX GTPase family; Region: HflX; cd01878 882095003976 G1 box; other site 882095003977 GTP/Mg2+ binding site [chemical binding]; other site 882095003978 Switch I region; other site 882095003979 G2 box; other site 882095003980 G3 box; other site 882095003981 Switch II region; other site 882095003982 G4 box; other site 882095003983 G5 box; other site 882095003984 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 882095003985 Aluminium resistance protein; Region: Alum_res; pfam06838 882095003986 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 882095003987 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882095003988 DNA binding residues [nucleotide binding] 882095003989 putative dimer interface [polypeptide binding]; other site 882095003990 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 882095003991 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 882095003992 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 882095003993 arsenical pump membrane protein; Provisional; Region: PRK15445 882095003994 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 882095003995 transmembrane helices; other site 882095003996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882095003997 LexA repressor; Validated; Region: PRK00215 882095003998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095003999 putative DNA binding site [nucleotide binding]; other site 882095004000 putative Zn2+ binding site [ion binding]; other site 882095004001 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 882095004002 Catalytic site [active] 882095004003 cell division suppressor protein YneA; Provisional; Region: PRK14125 882095004004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 882095004005 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 882095004006 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882095004007 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882095004008 TPP-binding site [chemical binding]; other site 882095004009 dimer interface [polypeptide binding]; other site 882095004010 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882095004011 PYR/PP interface [polypeptide binding]; other site 882095004012 dimer interface [polypeptide binding]; other site 882095004013 TPP binding site [chemical binding]; other site 882095004014 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095004015 hypothetical protein; Provisional; Region: PRK01844 882095004016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882095004017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882095004018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095004019 S-adenosylmethionine binding site [chemical binding]; other site 882095004020 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 882095004021 ParB-like nuclease domain; Region: ParBc; pfam02195 882095004022 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 882095004023 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 882095004024 Active Sites [active] 882095004025 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 882095004026 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095004027 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 882095004028 putative nucleotide binding site [chemical binding]; other site 882095004029 uridine monophosphate binding site [chemical binding]; other site 882095004030 homohexameric interface [polypeptide binding]; other site 882095004031 ribosome recycling factor; Reviewed; Region: frr; PRK00083 882095004032 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 882095004033 hinge region; other site 882095004034 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 882095004035 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 882095004036 catalytic residue [active] 882095004037 putative FPP diphosphate binding site; other site 882095004038 putative FPP binding hydrophobic cleft; other site 882095004039 dimer interface [polypeptide binding]; other site 882095004040 putative IPP diphosphate binding site; other site 882095004041 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 882095004042 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 882095004043 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 882095004044 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 882095004045 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 882095004046 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 882095004047 RIP metalloprotease RseP; Region: TIGR00054 882095004048 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882095004049 active site 882095004050 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 882095004051 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 882095004052 protein binding site [polypeptide binding]; other site 882095004053 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882095004054 putative substrate binding region [chemical binding]; other site 882095004055 prolyl-tRNA synthetase; Provisional; Region: PRK09194 882095004056 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 882095004057 dimer interface [polypeptide binding]; other site 882095004058 motif 1; other site 882095004059 active site 882095004060 motif 2; other site 882095004061 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 882095004062 putative deacylase active site [active] 882095004063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 882095004064 active site 882095004065 motif 3; other site 882095004066 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 882095004067 anticodon binding site; other site 882095004068 DNA polymerase III PolC; Validated; Region: polC; PRK00448 882095004069 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 882095004070 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 882095004071 generic binding surface II; other site 882095004072 generic binding surface I; other site 882095004073 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882095004074 active site 882095004075 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882095004076 active site 882095004077 catalytic site [active] 882095004078 substrate binding site [chemical binding]; other site 882095004079 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 882095004080 ribosome maturation protein RimP; Reviewed; Region: PRK00092 882095004081 Sm and related proteins; Region: Sm_like; cl00259 882095004082 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 882095004083 putative oligomer interface [polypeptide binding]; other site 882095004084 putative RNA binding site [nucleotide binding]; other site 882095004085 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 882095004086 NusA N-terminal domain; Region: NusA_N; pfam08529 882095004087 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 882095004088 RNA binding site [nucleotide binding]; other site 882095004089 homodimer interface [polypeptide binding]; other site 882095004090 NusA-like KH domain; Region: KH_5; pfam13184 882095004091 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 882095004092 G-X-X-G motif; other site 882095004093 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 882095004094 putative RNA binding cleft [nucleotide binding]; other site 882095004095 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 882095004096 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882095004097 translation initiation factor IF-2; Region: IF-2; TIGR00487 882095004098 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882095004099 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 882095004100 G1 box; other site 882095004101 putative GEF interaction site [polypeptide binding]; other site 882095004102 GTP/Mg2+ binding site [chemical binding]; other site 882095004103 Switch I region; other site 882095004104 G2 box; other site 882095004105 G3 box; other site 882095004106 Switch II region; other site 882095004107 G4 box; other site 882095004108 G5 box; other site 882095004109 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 882095004110 Translation-initiation factor 2; Region: IF-2; pfam11987 882095004111 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 882095004112 Protein of unknown function (DUF503); Region: DUF503; cl00669 882095004113 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 882095004114 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 882095004115 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 882095004116 RNA binding site [nucleotide binding]; other site 882095004117 active site 882095004118 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 882095004119 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882095004120 active site 882095004121 Riboflavin kinase; Region: Flavokinase; smart00904 882095004122 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 882095004123 16S/18S rRNA binding site [nucleotide binding]; other site 882095004124 S13e-L30e interaction site [polypeptide binding]; other site 882095004125 25S rRNA binding site [nucleotide binding]; other site 882095004126 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 882095004127 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 882095004128 RNase E interface [polypeptide binding]; other site 882095004129 trimer interface [polypeptide binding]; other site 882095004130 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 882095004131 RNase E interface [polypeptide binding]; other site 882095004132 trimer interface [polypeptide binding]; other site 882095004133 active site 882095004134 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 882095004135 putative nucleic acid binding region [nucleotide binding]; other site 882095004136 G-X-X-G motif; other site 882095004137 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 882095004138 RNA binding site [nucleotide binding]; other site 882095004139 domain interface; other site 882095004140 GTPase RsgA; Reviewed; Region: PRK01889 882095004141 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882095004142 RNA binding site [nucleotide binding]; other site 882095004143 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882095004144 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882095004145 GTP/Mg2+ binding site [chemical binding]; other site 882095004146 G4 box; other site 882095004147 G5 box; other site 882095004148 G1 box; other site 882095004149 Switch I region; other site 882095004150 G2 box; other site 882095004151 G3 box; other site 882095004152 Switch II region; other site 882095004153 YceG-like family; Region: YceG; pfam02618 882095004154 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 882095004155 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 882095004156 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 882095004157 Rhomboid family; Region: Rhomboid; pfam01694 882095004158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095004159 TPR motif; other site 882095004160 TPR repeat; Region: TPR_11; pfam13414 882095004161 binding surface 882095004162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 882095004163 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 882095004164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095004165 nucleotide binding site [chemical binding]; other site 882095004166 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 882095004167 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 882095004168 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 882095004169 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 882095004170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882095004171 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882095004172 Type II/IV secretion system protein; Region: T2SE; pfam00437 882095004173 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882095004174 Walker A motif; other site 882095004175 ATP binding site [chemical binding]; other site 882095004176 Walker B motif; other site 882095004177 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 882095004178 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 882095004179 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 882095004180 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 882095004181 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882095004182 tetramer interface [polypeptide binding]; other site 882095004183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095004184 catalytic residue [active] 882095004185 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882095004186 tetramer interface [polypeptide binding]; other site 882095004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095004188 catalytic residue [active] 882095004189 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882095004190 active site residue [active] 882095004191 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 882095004192 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882095004193 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882095004194 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882095004195 active site 882095004196 elongation factor P; Validated; Region: PRK00529 882095004197 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 882095004198 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 882095004199 RNA binding site [nucleotide binding]; other site 882095004200 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 882095004201 RNA binding site [nucleotide binding]; other site 882095004202 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 882095004203 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882095004204 carboxyltransferase (CT) interaction site; other site 882095004205 biotinylation site [posttranslational modification]; other site 882095004206 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 882095004207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882095004208 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882095004209 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882095004210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882095004211 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 882095004212 putative RNA binding site [nucleotide binding]; other site 882095004213 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 882095004214 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 882095004215 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 882095004216 homodimer interface [polypeptide binding]; other site 882095004217 NADP binding site [chemical binding]; other site 882095004218 substrate binding site [chemical binding]; other site 882095004219 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 882095004220 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 882095004221 generic binding surface II; other site 882095004222 generic binding surface I; other site 882095004223 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 882095004224 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882095004225 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882095004226 substrate binding pocket [chemical binding]; other site 882095004227 chain length determination region; other site 882095004228 substrate-Mg2+ binding site; other site 882095004229 catalytic residues [active] 882095004230 aspartate-rich region 1; other site 882095004231 active site lid residues [active] 882095004232 aspartate-rich region 2; other site 882095004233 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882095004234 DNA-binding site [nucleotide binding]; DNA binding site 882095004235 RNA-binding motif; other site 882095004236 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 882095004237 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 882095004238 TPP-binding site; other site 882095004239 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882095004240 PYR/PP interface [polypeptide binding]; other site 882095004241 dimer interface [polypeptide binding]; other site 882095004242 TPP binding site [chemical binding]; other site 882095004243 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095004244 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 882095004245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095004246 RNA binding surface [nucleotide binding]; other site 882095004247 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 882095004248 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 882095004249 arginine repressor; Provisional; Region: PRK04280 882095004250 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 882095004251 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 882095004252 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882095004253 Walker A/P-loop; other site 882095004254 ATP binding site [chemical binding]; other site 882095004255 Q-loop/lid; other site 882095004256 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882095004257 ABC transporter signature motif; other site 882095004258 Walker B; other site 882095004259 D-loop; other site 882095004260 H-loop/switch region; other site 882095004261 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 882095004262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095004263 nucleotide binding site [chemical binding]; other site 882095004264 Acetokinase family; Region: Acetate_kinase; cl17229 882095004265 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 882095004266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095004267 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882095004268 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 882095004269 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882095004270 tetramer interface [polypeptide binding]; other site 882095004271 TPP-binding site [chemical binding]; other site 882095004272 heterodimer interface [polypeptide binding]; other site 882095004273 phosphorylation loop region [posttranslational modification] 882095004274 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882095004275 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882095004276 alpha subunit interface [polypeptide binding]; other site 882095004277 TPP binding site [chemical binding]; other site 882095004278 heterodimer interface [polypeptide binding]; other site 882095004279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882095004280 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 882095004281 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882095004282 E3 interaction surface; other site 882095004283 lipoyl attachment site [posttranslational modification]; other site 882095004284 e3 binding domain; Region: E3_binding; pfam02817 882095004285 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882095004286 peptidase T-like protein; Region: PepT-like; TIGR01883 882095004287 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 882095004288 metal binding site [ion binding]; metal-binding site 882095004289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882095004290 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 882095004291 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 882095004292 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095004293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095004294 active site 882095004295 phosphorylation site [posttranslational modification] 882095004296 intermolecular recognition site; other site 882095004297 dimerization interface [polypeptide binding]; other site 882095004298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095004299 DNA binding site [nucleotide binding] 882095004300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882095004301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095004302 dimerization interface [polypeptide binding]; other site 882095004303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095004304 dimer interface [polypeptide binding]; other site 882095004305 phosphorylation site [posttranslational modification] 882095004306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095004307 ATP binding site [chemical binding]; other site 882095004308 Mg2+ binding site [ion binding]; other site 882095004309 G-X-G motif; other site 882095004310 OxaA-like protein precursor; Validated; Region: PRK01622 882095004311 acylphosphatase; Provisional; Region: PRK14443 882095004312 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 882095004313 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 882095004314 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 882095004315 homotetramer interface [polypeptide binding]; other site 882095004316 FMN binding site [chemical binding]; other site 882095004317 homodimer contacts [polypeptide binding]; other site 882095004318 putative active site [active] 882095004319 putative substrate binding site [chemical binding]; other site 882095004320 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 882095004321 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 882095004322 active site residue [active] 882095004323 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 882095004324 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882095004325 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095004326 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095004327 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 882095004328 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882095004329 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882095004330 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882095004331 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 882095004332 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 882095004333 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 882095004334 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 882095004335 ligand binding site [chemical binding]; other site 882095004336 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 882095004337 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 882095004338 Walker A/P-loop; other site 882095004339 ATP binding site [chemical binding]; other site 882095004340 Q-loop/lid; other site 882095004341 ABC transporter signature motif; other site 882095004342 Walker B; other site 882095004343 D-loop; other site 882095004344 H-loop/switch region; other site 882095004345 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 882095004346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882095004347 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882095004348 TM-ABC transporter signature motif; other site 882095004349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882095004350 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882095004351 TM-ABC transporter signature motif; other site 882095004352 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882095004353 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882095004354 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882095004355 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 882095004356 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882095004357 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882095004358 classical (c) SDRs; Region: SDR_c; cd05233 882095004359 NAD(P) binding site [chemical binding]; other site 882095004360 active site 882095004361 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 882095004362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095004363 non-specific DNA binding site [nucleotide binding]; other site 882095004364 salt bridge; other site 882095004365 sequence-specific DNA binding site [nucleotide binding]; other site 882095004366 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 882095004367 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 882095004368 competence damage-inducible protein A; Provisional; Region: PRK00549 882095004369 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 882095004370 putative MPT binding site; other site 882095004371 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 882095004372 recombinase A; Provisional; Region: recA; PRK09354 882095004373 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 882095004374 hexamer interface [polypeptide binding]; other site 882095004375 Walker A motif; other site 882095004376 ATP binding site [chemical binding]; other site 882095004377 Walker B motif; other site 882095004378 phosphodiesterase; Provisional; Region: PRK12704 882095004379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095004380 Zn2+ binding site [ion binding]; other site 882095004381 Mg2+ binding site [ion binding]; other site 882095004382 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 882095004383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095004384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882095004385 Coenzyme A binding pocket [chemical binding]; other site 882095004386 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 882095004387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882095004388 putative active site [active] 882095004389 metal binding site [ion binding]; metal-binding site 882095004390 homodimer binding site [polypeptide binding]; other site 882095004391 Predicted membrane protein [Function unknown]; Region: COG4550 882095004392 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 882095004393 MutS domain I; Region: MutS_I; pfam01624 882095004394 MutS domain II; Region: MutS_II; pfam05188 882095004395 MutS domain III; Region: MutS_III; pfam05192 882095004396 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 882095004397 Walker A/P-loop; other site 882095004398 ATP binding site [chemical binding]; other site 882095004399 Q-loop/lid; other site 882095004400 ABC transporter signature motif; other site 882095004401 Walker B; other site 882095004402 D-loop; other site 882095004403 H-loop/switch region; other site 882095004404 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 882095004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095004406 ATP binding site [chemical binding]; other site 882095004407 Mg2+ binding site [ion binding]; other site 882095004408 G-X-G motif; other site 882095004409 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 882095004410 ATP binding site [chemical binding]; other site 882095004411 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 882095004412 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 882095004413 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882095004414 Pyruvate formate lyase 1; Region: PFL1; cd01678 882095004415 coenzyme A binding site [chemical binding]; other site 882095004416 active site 882095004417 catalytic residues [active] 882095004418 glycine loop; other site 882095004419 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 882095004420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882095004421 FeS/SAM binding site; other site 882095004422 Predicted transcriptional regulators [Transcription]; Region: COG1695 882095004423 Transcriptional regulator PadR-like family; Region: PadR; cl17335 882095004424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095004425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095004426 putative substrate translocation pore; other site 882095004427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095004428 non-specific DNA binding site [nucleotide binding]; other site 882095004429 salt bridge; other site 882095004430 sequence-specific DNA binding site [nucleotide binding]; other site 882095004431 topology modulation protein; Reviewed; Region: PRK08118 882095004432 AAA domain; Region: AAA_17; pfam13207 882095004433 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095004434 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095004435 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095004436 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095004437 putative acyltransferase; Provisional; Region: PRK05790 882095004438 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 882095004439 dimer interface [polypeptide binding]; other site 882095004440 active site 882095004441 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 882095004442 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 882095004443 dimer interface [polypeptide binding]; other site 882095004444 active site 882095004445 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882095004446 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 882095004447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095004448 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 882095004449 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 882095004450 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882095004451 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882095004452 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 882095004453 FAD binding domain; Region: FAD_binding_4; pfam01565 882095004454 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 882095004455 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 882095004456 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882095004457 Walker A/P-loop; other site 882095004458 ATP binding site [chemical binding]; other site 882095004459 Q-loop/lid; other site 882095004460 ABC transporter signature motif; other site 882095004461 Walker B; other site 882095004462 D-loop; other site 882095004463 H-loop/switch region; other site 882095004464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095004465 dimer interface [polypeptide binding]; other site 882095004466 conserved gate region; other site 882095004467 ABC-ATPase subunit interface; other site 882095004468 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 882095004469 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 882095004470 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 882095004471 manganese transport protein MntH; Reviewed; Region: PRK00701 882095004472 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 882095004473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095004474 dimer interface [polypeptide binding]; other site 882095004475 conserved gate region; other site 882095004476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882095004477 ABC-ATPase subunit interface; other site 882095004478 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882095004479 LysR substrate binding domain; Region: LysR_substrate; pfam03466 882095004480 dimerization interface [polypeptide binding]; other site 882095004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095004482 dimer interface [polypeptide binding]; other site 882095004483 conserved gate region; other site 882095004484 putative PBP binding loops; other site 882095004485 ABC-ATPase subunit interface; other site 882095004486 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882095004487 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 882095004488 Walker A/P-loop; other site 882095004489 ATP binding site [chemical binding]; other site 882095004490 Q-loop/lid; other site 882095004491 ABC transporter signature motif; other site 882095004492 Walker B; other site 882095004493 D-loop; other site 882095004494 H-loop/switch region; other site 882095004495 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 882095004496 Predicted membrane protein [Function unknown]; Region: COG3859 882095004497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882095004498 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 882095004499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095004500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095004501 ABC transporter; Region: ABC_tran_2; pfam12848 882095004502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095004503 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 882095004504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095004505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095004506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882095004507 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882095004508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095004509 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882095004510 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 882095004511 dihydrodipicolinate synthase; Region: dapA; TIGR00674 882095004512 dimer interface [polypeptide binding]; other site 882095004513 active site 882095004514 catalytic residue [active] 882095004515 aspartate kinase I; Reviewed; Region: PRK08210 882095004516 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 882095004517 nucleotide binding site [chemical binding]; other site 882095004518 substrate binding site [chemical binding]; other site 882095004519 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 882095004520 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 882095004521 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 882095004522 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882095004523 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882095004524 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882095004525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882095004526 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 882095004527 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 882095004528 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 882095004529 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 882095004530 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 882095004531 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 882095004532 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 882095004533 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 882095004534 Predicted membrane protein [Function unknown]; Region: COG4392 882095004535 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882095004536 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882095004537 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882095004538 metal binding site 2 [ion binding]; metal-binding site 882095004539 putative DNA binding helix; other site 882095004540 metal binding site 1 [ion binding]; metal-binding site 882095004541 dimer interface [polypeptide binding]; other site 882095004542 structural Zn2+ binding site [ion binding]; other site 882095004543 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882095004544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095004545 ABC-ATPase subunit interface; other site 882095004546 dimer interface [polypeptide binding]; other site 882095004547 putative PBP binding regions; other site 882095004548 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882095004549 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882095004550 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 882095004551 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882095004552 DHHA2 domain; Region: DHHA2; pfam02833 882095004553 endonuclease IV; Provisional; Region: PRK01060 882095004554 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 882095004555 AP (apurinic/apyrimidinic) site pocket; other site 882095004556 DNA interaction; other site 882095004557 Metal-binding active site; metal-binding site 882095004558 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882095004559 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095004560 ATP binding site [chemical binding]; other site 882095004561 Mg++ binding site [ion binding]; other site 882095004562 motif III; other site 882095004563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095004564 nucleotide binding region [chemical binding]; other site 882095004565 ATP-binding site [chemical binding]; other site 882095004566 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 882095004567 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 882095004568 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882095004569 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882095004570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 882095004571 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882095004572 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882095004573 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 882095004574 Family of unknown function (DUF633); Region: DUF633; pfam04816 882095004575 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 882095004576 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 882095004577 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 882095004578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882095004579 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882095004580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882095004581 DNA binding residues [nucleotide binding] 882095004582 DNA primase; Validated; Region: dnaG; PRK05667 882095004583 CHC2 zinc finger; Region: zf-CHC2; pfam01807 882095004584 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 882095004585 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 882095004586 active site 882095004587 metal binding site [ion binding]; metal-binding site 882095004588 interdomain interaction site; other site 882095004589 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 882095004590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 882095004591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 882095004592 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 882095004593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 882095004594 DALR anticodon binding domain; Region: DALR_1; pfam05746 882095004595 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 882095004596 dimer interface [polypeptide binding]; other site 882095004597 motif 1; other site 882095004598 active site 882095004599 motif 2; other site 882095004600 motif 3; other site 882095004601 DNA repair protein RecO; Region: reco; TIGR00613 882095004602 Recombination protein O N terminal; Region: RecO_N; pfam11967 882095004603 Recombination protein O C terminal; Region: RecO_C; pfam02565 882095004604 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 882095004605 GTPase Era; Reviewed; Region: era; PRK00089 882095004606 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 882095004607 G1 box; other site 882095004608 GTP/Mg2+ binding site [chemical binding]; other site 882095004609 Switch I region; other site 882095004610 G2 box; other site 882095004611 Switch II region; other site 882095004612 G3 box; other site 882095004613 G4 box; other site 882095004614 G5 box; other site 882095004615 KH domain; Region: KH_2; pfam07650 882095004616 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 882095004617 active site 882095004618 catalytic motif [active] 882095004619 Zn binding site [ion binding]; other site 882095004620 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 882095004621 metal-binding heat shock protein; Provisional; Region: PRK00016 882095004622 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 882095004623 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 882095004624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095004625 Zn2+ binding site [ion binding]; other site 882095004626 Mg2+ binding site [ion binding]; other site 882095004627 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 882095004628 PhoH-like protein; Region: PhoH; pfam02562 882095004629 Yqey-like protein; Region: YqeY; pfam09424 882095004630 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 882095004631 RNA methyltransferase, RsmE family; Region: TIGR00046 882095004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 882095004633 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 882095004634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095004635 S-adenosylmethionine binding site [chemical binding]; other site 882095004636 chaperone protein DnaJ; Provisional; Region: PRK14280 882095004637 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 882095004638 HSP70 interaction site [polypeptide binding]; other site 882095004639 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 882095004640 substrate binding site [polypeptide binding]; other site 882095004641 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 882095004642 Zn binding sites [ion binding]; other site 882095004643 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 882095004644 dimer interface [polypeptide binding]; other site 882095004645 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 882095004646 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 882095004647 nucleotide binding site [chemical binding]; other site 882095004648 NEF interaction site [polypeptide binding]; other site 882095004649 SBD interface [polypeptide binding]; other site 882095004650 heat shock protein GrpE; Provisional; Region: PRK14140 882095004651 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 882095004652 dimer interface [polypeptide binding]; other site 882095004653 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 882095004654 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 882095004655 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 882095004656 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 882095004657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882095004658 FeS/SAM binding site; other site 882095004659 HemN C-terminal domain; Region: HemN_C; pfam06969 882095004660 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882095004661 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 882095004662 NADP binding site [chemical binding]; other site 882095004663 putative substrate binding site [chemical binding]; other site 882095004664 active site 882095004665 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095004666 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095004667 DNA binding residues [nucleotide binding] 882095004668 putative dimer interface [polypeptide binding]; other site 882095004669 GTP-binding protein LepA; Provisional; Region: PRK05433 882095004670 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 882095004671 G1 box; other site 882095004672 putative GEF interaction site [polypeptide binding]; other site 882095004673 GTP/Mg2+ binding site [chemical binding]; other site 882095004674 Switch I region; other site 882095004675 G2 box; other site 882095004676 G3 box; other site 882095004677 Switch II region; other site 882095004678 G4 box; other site 882095004679 G5 box; other site 882095004680 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 882095004681 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 882095004682 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 882095004683 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 882095004684 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 882095004685 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 882095004686 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 882095004687 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 882095004688 Competence protein; Region: Competence; pfam03772 882095004689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095004690 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 882095004691 catalytic motif [active] 882095004692 Zn binding site [ion binding]; other site 882095004693 SLBB domain; Region: SLBB; pfam10531 882095004694 comEA protein; Region: comE; TIGR01259 882095004695 Helix-hairpin-helix motif; Region: HHH; pfam00633 882095004696 Methyltransferase domain; Region: Methyltransf_23; pfam13489 882095004697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095004698 S-adenosylmethionine binding site [chemical binding]; other site 882095004699 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 882095004700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095004701 Zn2+ binding site [ion binding]; other site 882095004702 Mg2+ binding site [ion binding]; other site 882095004703 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 882095004704 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 882095004705 active site 882095004706 (T/H)XGH motif; other site 882095004707 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 882095004708 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 882095004709 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882095004710 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882095004711 shikimate binding site; other site 882095004712 NAD(P) binding site [chemical binding]; other site 882095004713 GTPase YqeH; Provisional; Region: PRK13796 882095004714 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 882095004715 GTP/Mg2+ binding site [chemical binding]; other site 882095004716 G4 box; other site 882095004717 G5 box; other site 882095004718 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 882095004719 G1 box; other site 882095004720 G1 box; other site 882095004721 GTP/Mg2+ binding site [chemical binding]; other site 882095004722 G2 box; other site 882095004723 Switch I region; other site 882095004724 G2 box; other site 882095004725 Switch I region; other site 882095004726 G3 box; other site 882095004727 G3 box; other site 882095004728 Switch II region; other site 882095004729 Switch II region; other site 882095004730 G4 box; other site 882095004731 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 882095004732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095004733 motif II; other site 882095004734 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 882095004735 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 882095004736 active site 882095004737 Zn binding site [ion binding]; other site 882095004738 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 882095004739 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 882095004740 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 882095004741 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 882095004742 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 882095004743 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 882095004744 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 882095004745 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 882095004746 Sugar specificity; other site 882095004747 Pyrimidine base specificity; other site 882095004748 ATP-binding site [chemical binding]; other site 882095004749 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 882095004750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095004751 S-adenosylmethionine binding site [chemical binding]; other site 882095004752 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 882095004753 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 882095004754 dimerization interface [polypeptide binding]; other site 882095004755 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882095004756 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882095004757 hypothetical protein; Provisional; Region: PRK13678 882095004758 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 882095004759 hypothetical protein; Provisional; Region: PRK05473 882095004760 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 882095004761 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 882095004762 motif 1; other site 882095004763 active site 882095004764 motif 2; other site 882095004765 motif 3; other site 882095004766 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882095004767 DHHA1 domain; Region: DHHA1; pfam02272 882095004768 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095004769 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095004770 Walker A/P-loop; other site 882095004771 ATP binding site [chemical binding]; other site 882095004772 Q-loop/lid; other site 882095004773 ABC transporter signature motif; other site 882095004774 Walker B; other site 882095004775 D-loop; other site 882095004776 H-loop/switch region; other site 882095004777 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095004778 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095004779 FtsX-like permease family; Region: FtsX; pfam02687 882095004780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095004781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095004782 active site 882095004783 phosphorylation site [posttranslational modification] 882095004784 intermolecular recognition site; other site 882095004785 dimerization interface [polypeptide binding]; other site 882095004786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095004787 DNA binding site [nucleotide binding] 882095004788 sensor kinase CusS; Provisional; Region: PRK09835 882095004789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095004790 dimerization interface [polypeptide binding]; other site 882095004791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095004792 dimer interface [polypeptide binding]; other site 882095004793 phosphorylation site [posttranslational modification] 882095004794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095004795 ATP binding site [chemical binding]; other site 882095004796 Mg2+ binding site [ion binding]; other site 882095004797 G-X-G motif; other site 882095004798 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 882095004799 AAA domain; Region: AAA_30; pfam13604 882095004800 Family description; Region: UvrD_C_2; pfam13538 882095004801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095004802 binding surface 882095004803 TPR motif; other site 882095004804 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 882095004805 TPR repeat; Region: TPR_11; pfam13414 882095004806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095004807 binding surface 882095004808 TPR motif; other site 882095004809 TPR repeat; Region: TPR_11; pfam13414 882095004810 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 882095004811 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 882095004812 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 882095004813 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882095004814 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882095004815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095004816 catalytic residue [active] 882095004817 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 882095004818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095004819 Walker A motif; other site 882095004820 ATP binding site [chemical binding]; other site 882095004821 Walker B motif; other site 882095004822 arginine finger; other site 882095004823 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 882095004824 Predicted transcriptional regulator [Transcription]; Region: COG1959 882095004825 Transcriptional regulator; Region: Rrf2; pfam02082 882095004826 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 882095004827 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 882095004828 Nitrogen regulatory protein P-II; Region: P-II; smart00938 882095004829 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 882095004830 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 882095004831 dimer interface [polypeptide binding]; other site 882095004832 anticodon binding site; other site 882095004833 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 882095004834 homodimer interface [polypeptide binding]; other site 882095004835 motif 1; other site 882095004836 active site 882095004837 motif 2; other site 882095004838 GAD domain; Region: GAD; pfam02938 882095004839 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 882095004840 motif 3; other site 882095004841 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 882095004842 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882095004843 dimer interface [polypeptide binding]; other site 882095004844 motif 1; other site 882095004845 active site 882095004846 motif 2; other site 882095004847 motif 3; other site 882095004848 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 882095004849 anticodon binding site; other site 882095004850 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882095004851 Bacterial SH3 domain; Region: SH3_3; pfam08239 882095004852 Bacterial SH3 domain; Region: SH3_3; pfam08239 882095004853 Bacterial SH3 domain homologues; Region: SH3b; smart00287 882095004854 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882095004855 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882095004856 active site 882095004857 metal binding site [ion binding]; metal-binding site 882095004858 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 882095004859 putative active site [active] 882095004860 dimerization interface [polypeptide binding]; other site 882095004861 putative tRNAtyr binding site [nucleotide binding]; other site 882095004862 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882095004863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095004864 Zn2+ binding site [ion binding]; other site 882095004865 Mg2+ binding site [ion binding]; other site 882095004866 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882095004867 synthetase active site [active] 882095004868 NTP binding site [chemical binding]; other site 882095004869 metal binding site [ion binding]; metal-binding site 882095004870 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 882095004871 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 882095004872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095004873 active site 882095004874 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 882095004875 DHH family; Region: DHH; pfam01368 882095004876 DHHA1 domain; Region: DHHA1; pfam02272 882095004877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 882095004878 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 882095004879 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 882095004880 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 882095004881 Protein export membrane protein; Region: SecD_SecF; cl14618 882095004882 Protein export membrane protein; Region: SecD_SecF; pfam02355 882095004883 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 882095004884 Preprotein translocase subunit; Region: YajC; pfam02699 882095004885 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 882095004886 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 882095004887 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 882095004888 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 882095004889 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 882095004890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095004891 Walker A motif; other site 882095004892 ATP binding site [chemical binding]; other site 882095004893 Walker B motif; other site 882095004894 arginine finger; other site 882095004895 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 882095004896 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 882095004897 RuvA N terminal domain; Region: RuvA_N; pfam01330 882095004898 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 882095004899 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882095004900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095004901 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882095004902 NAD binding site [chemical binding]; other site 882095004903 dimer interface [polypeptide binding]; other site 882095004904 substrate binding site [chemical binding]; other site 882095004905 hypothetical protein; Validated; Region: PRK00110 882095004906 prephenate dehydratase; Provisional; Region: PRK11898 882095004907 Prephenate dehydratase; Region: PDT; pfam00800 882095004908 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 882095004909 putative L-Phe binding site [chemical binding]; other site 882095004910 GTPase CgtA; Reviewed; Region: obgE; PRK12297 882095004911 GTP1/OBG; Region: GTP1_OBG; pfam01018 882095004912 Obg GTPase; Region: Obg; cd01898 882095004913 G1 box; other site 882095004914 GTP/Mg2+ binding site [chemical binding]; other site 882095004915 Switch I region; other site 882095004916 G2 box; other site 882095004917 G3 box; other site 882095004918 Switch II region; other site 882095004919 G4 box; other site 882095004920 G5 box; other site 882095004921 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 882095004922 glycerol kinase; Provisional; Region: glpK; PRK00047 882095004923 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 882095004924 N- and C-terminal domain interface [polypeptide binding]; other site 882095004925 active site 882095004926 MgATP binding site [chemical binding]; other site 882095004927 catalytic site [active] 882095004928 metal binding site [ion binding]; metal-binding site 882095004929 glycerol binding site [chemical binding]; other site 882095004930 homotetramer interface [polypeptide binding]; other site 882095004931 homodimer interface [polypeptide binding]; other site 882095004932 FBP binding site [chemical binding]; other site 882095004933 protein IIAGlc interface [polypeptide binding]; other site 882095004934 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882095004935 amphipathic channel; other site 882095004936 Asn-Pro-Ala signature motifs; other site 882095004937 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 882095004938 hypothetical protein; Provisional; Region: PRK14553 882095004939 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 882095004940 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 882095004941 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 882095004942 homodimer interface [polypeptide binding]; other site 882095004943 oligonucleotide binding site [chemical binding]; other site 882095004944 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 882095004945 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 882095004946 Switch I; other site 882095004947 Switch II; other site 882095004948 septum formation inhibitor; Reviewed; Region: minC; PRK00513 882095004949 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 882095004950 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 882095004951 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 882095004952 Protein of unknown function (DUF972); Region: DUF972; pfam06156 882095004953 rod shape-determining protein MreC; Region: MreC; pfam04085 882095004954 rod shape-determining protein MreB; Provisional; Region: PRK13927 882095004955 MreB and similar proteins; Region: MreB_like; cd10225 882095004956 nucleotide binding site [chemical binding]; other site 882095004957 Mg binding site [ion binding]; other site 882095004958 putative protofilament interaction site [polypeptide binding]; other site 882095004959 RodZ interaction site [polypeptide binding]; other site 882095004960 hypothetical protein; Reviewed; Region: PRK00024 882095004961 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 882095004962 MPN+ (JAMM) motif; other site 882095004963 Zinc-binding site [ion binding]; other site 882095004964 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 882095004965 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 882095004966 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 882095004967 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882095004968 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882095004969 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 882095004970 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 882095004971 active site 882095004972 HIGH motif; other site 882095004973 nucleotide binding site [chemical binding]; other site 882095004974 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882095004975 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 882095004976 active site 882095004977 KMSKS motif; other site 882095004978 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 882095004979 tRNA binding surface [nucleotide binding]; other site 882095004980 anticodon binding site; other site 882095004981 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 882095004982 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 882095004983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882095004984 inhibitor-cofactor binding pocket; inhibition site 882095004985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095004986 catalytic residue [active] 882095004987 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 882095004988 dimer interface [polypeptide binding]; other site 882095004989 active site 882095004990 Schiff base residues; other site 882095004991 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 882095004992 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882095004993 active site 882095004994 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 882095004995 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 882095004996 domain interfaces; other site 882095004997 active site 882095004998 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 882095004999 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 882095005000 tRNA; other site 882095005001 putative tRNA binding site [nucleotide binding]; other site 882095005002 putative NADP binding site [chemical binding]; other site 882095005003 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 882095005004 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 882095005005 G1 box; other site 882095005006 GTP/Mg2+ binding site [chemical binding]; other site 882095005007 Switch I region; other site 882095005008 G2 box; other site 882095005009 G3 box; other site 882095005010 Switch II region; other site 882095005011 G4 box; other site 882095005012 G5 box; other site 882095005013 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 882095005014 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 882095005015 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882095005016 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 882095005017 active site 882095005018 dimer interface [polypeptide binding]; other site 882095005019 motif 1; other site 882095005020 motif 2; other site 882095005021 motif 3; other site 882095005022 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 882095005023 anticodon binding site; other site 882095005024 primosomal protein DnaI; Reviewed; Region: PRK08939 882095005025 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 882095005026 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 882095005027 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882095005028 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 882095005029 ATP cone domain; Region: ATP-cone; pfam03477 882095005030 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 882095005031 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 882095005032 CoA-binding site [chemical binding]; other site 882095005033 ATP-binding [chemical binding]; other site 882095005034 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 882095005035 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 882095005036 DNA binding site [nucleotide binding] 882095005037 catalytic residue [active] 882095005038 H2TH interface [polypeptide binding]; other site 882095005039 putative catalytic residues [active] 882095005040 turnover-facilitating residue; other site 882095005041 intercalation triad [nucleotide binding]; other site 882095005042 8OG recognition residue [nucleotide binding]; other site 882095005043 putative reading head residues; other site 882095005044 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 882095005045 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882095005046 DNA polymerase I; Provisional; Region: PRK05755 882095005047 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882095005048 active site 882095005049 metal binding site 1 [ion binding]; metal-binding site 882095005050 putative 5' ssDNA interaction site; other site 882095005051 metal binding site 3; metal-binding site 882095005052 metal binding site 2 [ion binding]; metal-binding site 882095005053 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882095005054 putative DNA binding site [nucleotide binding]; other site 882095005055 putative metal binding site [ion binding]; other site 882095005056 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 882095005057 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 882095005058 active site 882095005059 DNA binding site [nucleotide binding] 882095005060 catalytic site [active] 882095005061 isocitrate dehydrogenase; Reviewed; Region: PRK07006 882095005062 isocitrate dehydrogenase; Validated; Region: PRK07362 882095005063 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 882095005064 dimer interface [polypeptide binding]; other site 882095005065 Citrate synthase; Region: Citrate_synt; pfam00285 882095005066 active site 882095005067 citrylCoA binding site [chemical binding]; other site 882095005068 oxalacetate/citrate binding site [chemical binding]; other site 882095005069 coenzyme A binding site [chemical binding]; other site 882095005070 catalytic triad [active] 882095005071 Protein of unknown function (DUF441); Region: DUF441; pfam04284 882095005072 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 882095005073 pyruvate kinase; Provisional; Region: PRK06354 882095005074 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 882095005075 domain interfaces; other site 882095005076 active site 882095005077 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 882095005078 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 882095005079 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 882095005080 active site 882095005081 ADP/pyrophosphate binding site [chemical binding]; other site 882095005082 dimerization interface [polypeptide binding]; other site 882095005083 allosteric effector site; other site 882095005084 fructose-1,6-bisphosphate binding site; other site 882095005085 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 882095005086 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 882095005087 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 882095005088 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 882095005089 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 882095005090 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 882095005091 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882095005092 active site 882095005093 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 882095005094 generic binding surface I; other site 882095005095 generic binding surface II; other site 882095005096 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 882095005097 DHH family; Region: DHH; pfam01368 882095005098 DHHA1 domain; Region: DHHA1; pfam02272 882095005099 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 882095005100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 882095005101 DNA-binding site [nucleotide binding]; DNA binding site 882095005102 DRTGG domain; Region: DRTGG; pfam07085 882095005103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 882095005104 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 882095005105 active site 2 [active] 882095005106 active site 1 [active] 882095005107 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882095005108 metal-dependent hydrolase; Provisional; Region: PRK00685 882095005109 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882095005110 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882095005111 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882095005112 active site 882095005113 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 882095005114 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 882095005115 hexamer interface [polypeptide binding]; other site 882095005116 ligand binding site [chemical binding]; other site 882095005117 putative active site [active] 882095005118 NAD(P) binding site [chemical binding]; other site 882095005119 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882095005120 Ligand Binding Site [chemical binding]; other site 882095005121 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882095005122 propionate/acetate kinase; Provisional; Region: PRK12379 882095005123 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 882095005124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005125 S-adenosylmethionine binding site [chemical binding]; other site 882095005126 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 882095005127 dimer interface [polypeptide binding]; other site 882095005128 catalytic triad [active] 882095005129 peroxidatic and resolving cysteines [active] 882095005130 RDD family; Region: RDD; pfam06271 882095005131 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 882095005132 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 882095005133 tandem repeat interface [polypeptide binding]; other site 882095005134 oligomer interface [polypeptide binding]; other site 882095005135 active site residues [active] 882095005136 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 882095005137 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882095005138 ornithine carbamoyltransferase; Provisional; Region: PRK00779 882095005139 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882095005140 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882095005141 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 882095005142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882095005143 inhibitor-cofactor binding pocket; inhibition site 882095005144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095005145 catalytic residue [active] 882095005146 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 882095005147 nucleotide binding site [chemical binding]; other site 882095005148 N-acetyl-L-glutamate binding site [chemical binding]; other site 882095005149 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 882095005150 heterotetramer interface [polypeptide binding]; other site 882095005151 active site pocket [active] 882095005152 cleavage site 882095005153 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 882095005154 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882095005155 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 882095005156 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 882095005157 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 882095005158 Ligand Binding Site [chemical binding]; other site 882095005159 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882095005160 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882095005161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095005162 catalytic residue [active] 882095005163 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 882095005164 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 882095005165 GAF domain; Region: GAF_2; pfam13185 882095005166 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 882095005167 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 882095005168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095005169 RNA binding surface [nucleotide binding]; other site 882095005170 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 882095005171 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 882095005172 active site 882095005173 HIGH motif; other site 882095005174 dimer interface [polypeptide binding]; other site 882095005175 KMSKS motif; other site 882095005176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095005177 RNA binding surface [nucleotide binding]; other site 882095005178 catabolite control protein A; Region: ccpA; TIGR01481 882095005179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095005180 DNA binding site [nucleotide binding] 882095005181 domain linker motif; other site 882095005182 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 882095005183 dimerization interface [polypeptide binding]; other site 882095005184 effector binding site; other site 882095005185 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 882095005186 Chorismate mutase type II; Region: CM_2; cl00693 882095005187 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 882095005188 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882095005189 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 882095005190 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882095005191 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882095005192 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 882095005193 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 882095005194 dimer interface [polypeptide binding]; other site 882095005195 decamer (pentamer of dimers) interface [polypeptide binding]; other site 882095005196 catalytic triad [active] 882095005197 peroxidatic and resolving cysteines [active] 882095005198 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 882095005199 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882095005200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882095005201 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882095005202 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882095005203 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882095005204 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882095005205 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882095005206 putative tRNA-binding site [nucleotide binding]; other site 882095005207 hypothetical protein; Provisional; Region: PRK13668 882095005208 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095005209 catalytic residues [active] 882095005210 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882095005211 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882095005212 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882095005213 oligomer interface [polypeptide binding]; other site 882095005214 active site 882095005215 metal binding site [ion binding]; metal-binding site 882095005216 Predicted small secreted protein [Function unknown]; Region: COG5584 882095005217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 882095005218 putative homodimer interface [polypeptide binding]; other site 882095005219 putative homotetramer interface [polypeptide binding]; other site 882095005220 putative allosteric switch controlling residues; other site 882095005221 putative metal binding site [ion binding]; other site 882095005222 putative homodimer-homodimer interface [polypeptide binding]; other site 882095005223 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095005224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005225 S-adenosylmethionine binding site [chemical binding]; other site 882095005226 Phosphotransferase enzyme family; Region: APH; pfam01636 882095005227 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882095005228 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882095005229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095005230 putative substrate translocation pore; other site 882095005231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095005232 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095005233 MarR family; Region: MarR; pfam01047 882095005234 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882095005235 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 882095005236 homodimer interface [polypeptide binding]; other site 882095005237 substrate-cofactor binding pocket; other site 882095005238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095005239 catalytic residue [active] 882095005240 dipeptidase PepV; Reviewed; Region: PRK07318 882095005241 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 882095005242 active site 882095005243 metal binding site [ion binding]; metal-binding site 882095005244 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 882095005245 nudix motif; other site 882095005246 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 882095005247 putative substrate binding site [chemical binding]; other site 882095005248 putative ATP binding site [chemical binding]; other site 882095005249 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882095005250 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882095005251 active site 882095005252 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882095005253 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882095005254 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882095005255 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882095005256 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 882095005257 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 882095005258 substrate binding site [chemical binding]; other site 882095005259 active site 882095005260 catalytic residues [active] 882095005261 heterodimer interface [polypeptide binding]; other site 882095005262 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 882095005263 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 882095005264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095005265 catalytic residue [active] 882095005266 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 882095005267 active site 882095005268 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 882095005269 active site 882095005270 ribulose/triose binding site [chemical binding]; other site 882095005271 phosphate binding site [ion binding]; other site 882095005272 substrate (anthranilate) binding pocket [chemical binding]; other site 882095005273 product (indole) binding pocket [chemical binding]; other site 882095005274 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 882095005275 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882095005276 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882095005277 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882095005278 Glutamine amidotransferase class-I; Region: GATase; pfam00117 882095005279 glutamine binding [chemical binding]; other site 882095005280 catalytic triad [active] 882095005281 anthranilate synthase component I; Provisional; Region: PRK13570 882095005282 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 882095005283 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 882095005284 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 882095005285 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882095005286 putative catalytic cysteine [active] 882095005287 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 882095005288 putative active site [active] 882095005289 metal binding site [ion binding]; metal-binding site 882095005290 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882095005291 dimer interface [polypeptide binding]; other site 882095005292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095005293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095005294 Walker A/P-loop; other site 882095005295 ATP binding site [chemical binding]; other site 882095005296 Q-loop/lid; other site 882095005297 ABC transporter signature motif; other site 882095005298 Walker B; other site 882095005299 D-loop; other site 882095005300 H-loop/switch region; other site 882095005301 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882095005302 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882095005303 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882095005304 putative dimer interface [polypeptide binding]; other site 882095005305 catalytic triad [active] 882095005306 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 882095005307 aconitate hydratase; Validated; Region: PRK09277 882095005308 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 882095005309 substrate binding site [chemical binding]; other site 882095005310 ligand binding site [chemical binding]; other site 882095005311 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 882095005312 substrate binding site [chemical binding]; other site 882095005313 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882095005314 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 882095005315 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 882095005316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095005317 ATP binding site [chemical binding]; other site 882095005318 putative Mg++ binding site [ion binding]; other site 882095005319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095005320 nucleotide binding region [chemical binding]; other site 882095005321 ATP-binding site [chemical binding]; other site 882095005322 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 882095005323 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882095005324 Walker A/P-loop; other site 882095005325 ATP binding site [chemical binding]; other site 882095005326 Q-loop/lid; other site 882095005327 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882095005328 ABC transporter signature motif; other site 882095005329 Walker B; other site 882095005330 D-loop; other site 882095005331 H-loop/switch region; other site 882095005332 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882095005333 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882095005334 active site 882095005335 metal binding site [ion binding]; metal-binding site 882095005336 DNA binding site [nucleotide binding] 882095005337 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 882095005338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 882095005339 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 882095005340 putative acyl-acceptor binding pocket; other site 882095005341 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 882095005342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095005343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095005344 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882095005345 Walker A/P-loop; other site 882095005346 ATP binding site [chemical binding]; other site 882095005347 Q-loop/lid; other site 882095005348 ABC transporter signature motif; other site 882095005349 Walker B; other site 882095005350 D-loop; other site 882095005351 H-loop/switch region; other site 882095005352 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095005353 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 882095005354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095005355 Walker A/P-loop; other site 882095005356 ATP binding site [chemical binding]; other site 882095005357 Q-loop/lid; other site 882095005358 ABC transporter signature motif; other site 882095005359 Walker B; other site 882095005360 D-loop; other site 882095005361 H-loop/switch region; other site 882095005362 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882095005363 active site 882095005364 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882095005365 elongation factor Ts; Provisional; Region: tsf; PRK09377 882095005366 UBA/TS-N domain; Region: UBA; pfam00627 882095005367 Elongation factor TS; Region: EF_TS; pfam00889 882095005368 Elongation factor TS; Region: EF_TS; pfam00889 882095005369 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 882095005370 rRNA interaction site [nucleotide binding]; other site 882095005371 S8 interaction site; other site 882095005372 putative laminin-1 binding site; other site 882095005373 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882095005374 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 882095005375 active site turn [active] 882095005376 phosphorylation site [posttranslational modification] 882095005377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882095005378 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 882095005379 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 882095005380 putative active site [active] 882095005381 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095005382 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095005383 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095005384 putative active site [active] 882095005385 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 882095005386 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882095005387 HIGH motif; other site 882095005388 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882095005389 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882095005390 active site 882095005391 KMSKS motif; other site 882095005392 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 882095005393 tRNA binding surface [nucleotide binding]; other site 882095005394 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 882095005395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882095005396 FeS/SAM binding site; other site 882095005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005398 S-adenosylmethionine binding site [chemical binding]; other site 882095005399 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 882095005400 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 882095005401 active site 882095005402 dimer interface [polypeptide binding]; other site 882095005403 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 882095005404 Ligand Binding Site [chemical binding]; other site 882095005405 Molecular Tunnel; other site 882095005406 S-adenosylmethionine synthetase; Validated; Region: PRK05250 882095005407 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 882095005408 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 882095005409 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 882095005410 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 882095005411 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 882095005412 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882095005413 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095005414 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882095005415 NAD binding site [chemical binding]; other site 882095005416 dimer interface [polypeptide binding]; other site 882095005417 substrate binding site [chemical binding]; other site 882095005418 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 882095005419 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 882095005420 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 882095005421 nudix motif; other site 882095005422 Uncharacterized conserved protein [Function unknown]; Region: COG0759 882095005423 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882095005424 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882095005425 metal binding site [ion binding]; metal-binding site 882095005426 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 882095005427 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 882095005428 acyl-activating enzyme (AAE) consensus motif; other site 882095005429 putative AMP binding site [chemical binding]; other site 882095005430 putative active site [active] 882095005431 putative CoA binding site [chemical binding]; other site 882095005432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 882095005433 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 882095005434 substrate binding site [chemical binding]; other site 882095005435 oxyanion hole (OAH) forming residues; other site 882095005436 trimer interface [polypeptide binding]; other site 882095005437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095005438 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 882095005439 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 882095005440 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 882095005441 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 882095005442 dimer interface [polypeptide binding]; other site 882095005443 tetramer interface [polypeptide binding]; other site 882095005444 PYR/PP interface [polypeptide binding]; other site 882095005445 TPP binding site [chemical binding]; other site 882095005446 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 882095005447 TPP-binding site; other site 882095005448 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 882095005449 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882095005450 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 882095005451 UbiA prenyltransferase family; Region: UbiA; pfam01040 882095005452 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 882095005453 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 882095005454 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 882095005455 FAD binding site [chemical binding]; other site 882095005456 cystathionine beta-lyase; Provisional; Region: PRK08064 882095005457 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882095005458 homodimer interface [polypeptide binding]; other site 882095005459 substrate-cofactor binding pocket; other site 882095005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095005461 catalytic residue [active] 882095005462 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882095005463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095005464 catalytic residue [active] 882095005465 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 882095005466 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 882095005467 THF binding site; other site 882095005468 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882095005469 substrate binding site [chemical binding]; other site 882095005470 THF binding site; other site 882095005471 zinc-binding site [ion binding]; other site 882095005472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095005473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095005474 putative substrate translocation pore; other site 882095005475 ferric uptake regulator; Provisional; Region: fur; PRK09462 882095005476 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882095005477 metal binding site 2 [ion binding]; metal-binding site 882095005478 putative DNA binding helix; other site 882095005479 metal binding site 1 [ion binding]; metal-binding site 882095005480 dimer interface [polypeptide binding]; other site 882095005481 structural Zn2+ binding site [ion binding]; other site 882095005482 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882095005483 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882095005484 NAD binding site [chemical binding]; other site 882095005485 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 882095005486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882095005487 inhibitor-cofactor binding pocket; inhibition site 882095005488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095005489 catalytic residue [active] 882095005490 Predicted membrane protein [Function unknown]; Region: COG4129 882095005491 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882095005492 hypothetical protein; Provisional; Region: PRK13662 882095005493 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 882095005494 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 882095005495 putative NAD(P) binding site [chemical binding]; other site 882095005496 active site 882095005497 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 882095005498 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882095005499 minor groove reading motif; other site 882095005500 helix-hairpin-helix signature motif; other site 882095005501 substrate binding pocket [chemical binding]; other site 882095005502 active site 882095005503 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 882095005504 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 882095005505 DNA binding and oxoG recognition site [nucleotide binding] 882095005506 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 882095005507 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 882095005508 trimer interface [polypeptide binding]; other site 882095005509 active site 882095005510 WVELL protein; Region: WVELL; pfam14043 882095005511 recombination regulator RecX; Provisional; Region: recX; PRK14135 882095005512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882095005513 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 882095005514 NAD(P) binding site [chemical binding]; other site 882095005515 active site 882095005516 Predicted integral membrane protein [Function unknown]; Region: COG0392 882095005517 Uncharacterized conserved protein [Function unknown]; Region: COG2898 882095005518 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 882095005519 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882095005520 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882095005521 Cation efflux family; Region: Cation_efflux; pfam01545 882095005522 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882095005523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882095005524 PAS fold; Region: PAS_4; pfam08448 882095005525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882095005526 putative active site [active] 882095005527 heme pocket [chemical binding]; other site 882095005528 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882095005529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882095005530 dimer interface [polypeptide binding]; other site 882095005531 putative CheW interface [polypeptide binding]; other site 882095005532 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 882095005533 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 882095005534 dimer interface [polypeptide binding]; other site 882095005535 active site 882095005536 Mn binding site [ion binding]; other site 882095005537 TRAM domain; Region: TRAM; cl01282 882095005538 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882095005539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005540 S-adenosylmethionine binding site [chemical binding]; other site 882095005541 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882095005542 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 882095005543 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 882095005544 Substrate-binding site [chemical binding]; other site 882095005545 Substrate specificity [chemical binding]; other site 882095005546 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 882095005547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 882095005548 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 882095005549 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 882095005550 active site 882095005551 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 882095005552 flavodoxin, short chain; Region: flav_short; TIGR01753 882095005553 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882095005554 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882095005555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095005556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095005557 putative substrate translocation pore; other site 882095005558 rod-share determining protein MreBH; Provisional; Region: PRK13929 882095005559 MreB and similar proteins; Region: MreB_like; cd10225 882095005560 nucleotide binding site [chemical binding]; other site 882095005561 Mg binding site [ion binding]; other site 882095005562 putative protofilament interaction site [polypeptide binding]; other site 882095005563 RodZ interaction site [polypeptide binding]; other site 882095005564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005565 S-adenosylmethionine binding site [chemical binding]; other site 882095005566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095005567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095005568 Uncharacterized conserved protein [Function unknown]; Region: COG3589 882095005569 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 882095005570 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095005571 methionine cluster; other site 882095005572 active site 882095005573 phosphorylation site [posttranslational modification] 882095005574 metal binding site [ion binding]; metal-binding site 882095005575 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095005576 active site 882095005577 P-loop; other site 882095005578 phosphorylation site [posttranslational modification] 882095005579 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882095005580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095005581 Walker A motif; other site 882095005582 ATP binding site [chemical binding]; other site 882095005583 Walker B motif; other site 882095005584 arginine finger; other site 882095005585 Transcriptional antiterminator [Transcription]; Region: COG3933 882095005586 PRD domain; Region: PRD; pfam00874 882095005587 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095005588 active pocket/dimerization site; other site 882095005589 active site 882095005590 phosphorylation site [posttranslational modification] 882095005591 PRD domain; Region: PRD; pfam00874 882095005592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882095005593 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095005594 ATP binding site [chemical binding]; other site 882095005595 putative Mg++ binding site [ion binding]; other site 882095005596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095005597 nucleotide binding region [chemical binding]; other site 882095005598 ATP-binding site [chemical binding]; other site 882095005599 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882095005600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095005601 Walker A/P-loop; other site 882095005602 ATP binding site [chemical binding]; other site 882095005603 Q-loop/lid; other site 882095005604 ABC transporter signature motif; other site 882095005605 Walker B; other site 882095005606 D-loop; other site 882095005607 H-loop/switch region; other site 882095005608 Predicted transcriptional regulators [Transcription]; Region: COG1725 882095005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095005610 DNA-binding site [nucleotide binding]; DNA binding site 882095005611 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095005612 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095005613 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095005614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095005615 DNA binding site [nucleotide binding] 882095005616 domain linker motif; other site 882095005617 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882095005618 dimerization interface [polypeptide binding]; other site 882095005619 ligand binding site [chemical binding]; other site 882095005620 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 882095005621 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882095005622 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882095005623 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882095005624 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882095005625 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095005626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095005627 dimer interface [polypeptide binding]; other site 882095005628 conserved gate region; other site 882095005629 putative PBP binding loops; other site 882095005630 ABC-ATPase subunit interface; other site 882095005631 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095005632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095005633 dimer interface [polypeptide binding]; other site 882095005634 conserved gate region; other site 882095005635 putative PBP binding loops; other site 882095005636 ABC-ATPase subunit interface; other site 882095005637 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 882095005638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882095005639 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 882095005640 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 882095005641 active site 882095005642 dimer interface [polypeptide binding]; other site 882095005643 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 882095005644 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 882095005645 active site 882095005646 FMN binding site [chemical binding]; other site 882095005647 substrate binding site [chemical binding]; other site 882095005648 3Fe-4S cluster binding site [ion binding]; other site 882095005649 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 882095005650 domain interface; other site 882095005651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095005652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095005653 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882095005654 putative dimerization interface [polypeptide binding]; other site 882095005655 Predicted acetyltransferase [General function prediction only]; Region: COG3153 882095005656 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 882095005657 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 882095005658 putative active site [active] 882095005659 metal binding site [ion binding]; metal-binding site 882095005660 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882095005661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882095005662 substrate binding pocket [chemical binding]; other site 882095005663 membrane-bound complex binding site; other site 882095005664 hinge residues; other site 882095005665 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095005666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095005667 Walker A/P-loop; other site 882095005668 ATP binding site [chemical binding]; other site 882095005669 Q-loop/lid; other site 882095005670 ABC transporter signature motif; other site 882095005671 Walker B; other site 882095005672 D-loop; other site 882095005673 H-loop/switch region; other site 882095005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095005675 dimer interface [polypeptide binding]; other site 882095005676 conserved gate region; other site 882095005677 putative PBP binding loops; other site 882095005678 ABC-ATPase subunit interface; other site 882095005679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882095005680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 882095005681 dimer interface [polypeptide binding]; other site 882095005682 phosphorylation site [posttranslational modification] 882095005683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095005684 ATP binding site [chemical binding]; other site 882095005685 Mg2+ binding site [ion binding]; other site 882095005686 G-X-G motif; other site 882095005687 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 882095005688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882095005689 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 882095005690 active site 882095005691 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882095005692 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 882095005693 putative NAD(P) binding site [chemical binding]; other site 882095005694 active site 882095005695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095005697 active site 882095005698 phosphorylation site [posttranslational modification] 882095005699 intermolecular recognition site; other site 882095005700 dimerization interface [polypeptide binding]; other site 882095005701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095005702 DNA binding site [nucleotide binding] 882095005703 FtsX-like permease family; Region: FtsX; pfam02687 882095005704 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095005705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095005706 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095005707 Walker A/P-loop; other site 882095005708 ATP binding site [chemical binding]; other site 882095005709 Q-loop/lid; other site 882095005710 ABC transporter signature motif; other site 882095005711 Walker B; other site 882095005712 D-loop; other site 882095005713 H-loop/switch region; other site 882095005714 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 882095005715 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 882095005716 ADP binding site [chemical binding]; other site 882095005717 magnesium binding site [ion binding]; other site 882095005718 putative shikimate binding site; other site 882095005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 882095005720 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882095005721 TRAM domain; Region: TRAM; pfam01938 882095005722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005723 S-adenosylmethionine binding site [chemical binding]; other site 882095005724 putative lipid kinase; Reviewed; Region: PRK13337 882095005725 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882095005726 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 882095005727 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 882095005728 GatB domain; Region: GatB_Yqey; smart00845 882095005729 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 882095005730 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 882095005731 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 882095005732 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 882095005733 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 882095005734 putative dimer interface [polypeptide binding]; other site 882095005735 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 882095005736 putative dimer interface [polypeptide binding]; other site 882095005737 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 882095005738 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 882095005739 nucleotide binding pocket [chemical binding]; other site 882095005740 K-X-D-G motif; other site 882095005741 catalytic site [active] 882095005742 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 882095005743 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 882095005744 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 882095005745 Dimer interface [polypeptide binding]; other site 882095005746 BRCT sequence motif; other site 882095005747 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 882095005748 Part of AAA domain; Region: AAA_19; pfam13245 882095005749 Family description; Region: UvrD_C_2; pfam13538 882095005750 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 882095005751 PcrB family; Region: PcrB; pfam01884 882095005752 substrate binding site [chemical binding]; other site 882095005753 putative active site [active] 882095005754 dimer interface [polypeptide binding]; other site 882095005755 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 882095005756 Na2 binding site [ion binding]; other site 882095005757 putative substrate binding site 1 [chemical binding]; other site 882095005758 Na binding site 1 [ion binding]; other site 882095005759 putative substrate binding site 2 [chemical binding]; other site 882095005760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 882095005761 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 882095005762 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 882095005763 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 882095005764 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 882095005765 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 882095005766 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 882095005767 purine monophosphate binding site [chemical binding]; other site 882095005768 dimer interface [polypeptide binding]; other site 882095005769 putative catalytic residues [active] 882095005770 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 882095005771 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 882095005772 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 882095005773 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 882095005774 active site 882095005775 substrate binding site [chemical binding]; other site 882095005776 cosubstrate binding site; other site 882095005777 catalytic site [active] 882095005778 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 882095005779 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 882095005780 dimerization interface [polypeptide binding]; other site 882095005781 putative ATP binding site [chemical binding]; other site 882095005782 amidophosphoribosyltransferase; Provisional; Region: PRK06781 882095005783 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 882095005784 active site 882095005785 tetramer interface [polypeptide binding]; other site 882095005786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095005787 active site 882095005788 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 882095005789 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 882095005790 dimerization interface [polypeptide binding]; other site 882095005791 ATP binding site [chemical binding]; other site 882095005792 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 882095005793 dimerization interface [polypeptide binding]; other site 882095005794 ATP binding site [chemical binding]; other site 882095005795 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 882095005796 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 882095005797 putative active site [active] 882095005798 catalytic triad [active] 882095005799 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 882095005800 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 882095005801 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 882095005802 ATP binding site [chemical binding]; other site 882095005803 active site 882095005804 substrate binding site [chemical binding]; other site 882095005805 adenylosuccinate lyase; Provisional; Region: PRK07492 882095005806 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 882095005807 tetramer interface [polypeptide binding]; other site 882095005808 active site 882095005809 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882095005810 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 882095005811 NAD binding site [chemical binding]; other site 882095005812 ATP-grasp domain; Region: ATP-grasp; pfam02222 882095005813 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 882095005814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 882095005815 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095005816 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 882095005817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095005818 Zn2+ binding site [ion binding]; other site 882095005819 Mg2+ binding site [ion binding]; other site 882095005820 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882095005821 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882095005822 Walker A/P-loop; other site 882095005823 ATP binding site [chemical binding]; other site 882095005824 Q-loop/lid; other site 882095005825 ABC transporter signature motif; other site 882095005826 Walker B; other site 882095005827 D-loop; other site 882095005828 H-loop/switch region; other site 882095005829 peptidase T; Region: peptidase-T; TIGR01882 882095005830 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 882095005831 metal binding site [ion binding]; metal-binding site 882095005832 dimer interface [polypeptide binding]; other site 882095005833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 882095005834 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 882095005835 active site 882095005836 putative catalytic site [active] 882095005837 DNA binding site [nucleotide binding] 882095005838 putative phosphate binding site [ion binding]; other site 882095005839 metal binding site A [ion binding]; metal-binding site 882095005840 AP binding site [nucleotide binding]; other site 882095005841 metal binding site B [ion binding]; metal-binding site 882095005842 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 882095005843 23S rRNA binding site [nucleotide binding]; other site 882095005844 L21 binding site [polypeptide binding]; other site 882095005845 L13 binding site [polypeptide binding]; other site 882095005846 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 882095005847 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 882095005848 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 882095005849 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 882095005850 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095005851 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095005852 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095005853 Substrate binding site [chemical binding]; other site 882095005854 Leucine rich repeat; Region: LRR_8; pfam13855 882095005855 LRR adjacent; Region: LRR_adjacent; pfam08191 882095005856 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 882095005857 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 882095005858 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882095005859 DNA binding residues [nucleotide binding] 882095005860 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882095005861 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882095005862 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095005863 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 882095005864 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 882095005865 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 882095005866 RimM N-terminal domain; Region: RimM; pfam01782 882095005867 PRC-barrel domain; Region: PRC; pfam05239 882095005868 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 882095005869 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 882095005870 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 882095005871 catalytic triad [active] 882095005872 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 882095005873 KH domain; Region: KH_4; pfam13083 882095005874 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 882095005875 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 882095005876 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882095005877 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882095005878 signal recognition particle protein; Provisional; Region: PRK10867 882095005879 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 882095005880 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882095005881 P loop; other site 882095005882 GTP binding site [chemical binding]; other site 882095005883 Signal peptide binding domain; Region: SRP_SPB; pfam02978 882095005884 putative DNA-binding protein; Validated; Region: PRK00118 882095005885 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 882095005886 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 882095005887 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 882095005888 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882095005889 P loop; other site 882095005890 GTP binding site [chemical binding]; other site 882095005891 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 882095005892 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882095005893 Walker A/P-loop; other site 882095005894 ATP binding site [chemical binding]; other site 882095005895 Q-loop/lid; other site 882095005896 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 882095005897 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 882095005898 linker region; other site 882095005899 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882095005900 ABC transporter signature motif; other site 882095005901 Walker B; other site 882095005902 D-loop; other site 882095005903 H-loop/switch region; other site 882095005904 ribonuclease III; Reviewed; Region: rnc; PRK00102 882095005905 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882095005906 dimerization interface [polypeptide binding]; other site 882095005907 active site 882095005908 metal binding site [ion binding]; metal-binding site 882095005909 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 882095005910 dsRNA binding site [nucleotide binding]; other site 882095005911 acyl carrier protein; Provisional; Region: acpP; PRK00982 882095005912 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882095005913 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 882095005914 NAD(P) binding site [chemical binding]; other site 882095005915 homotetramer interface [polypeptide binding]; other site 882095005916 homodimer interface [polypeptide binding]; other site 882095005917 active site 882095005918 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 882095005919 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 882095005920 putative phosphate acyltransferase; Provisional; Region: PRK05331 882095005921 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 882095005922 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 882095005923 active site 2 [active] 882095005924 active site 1 [active] 882095005925 Y-family of DNA polymerases; Region: PolY; cl12025 882095005926 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 882095005927 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 882095005928 generic binding surface II; other site 882095005929 ssDNA binding site; other site 882095005930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095005931 ATP binding site [chemical binding]; other site 882095005932 putative Mg++ binding site [ion binding]; other site 882095005933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095005934 nucleotide binding region [chemical binding]; other site 882095005935 ATP-binding site [chemical binding]; other site 882095005936 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 882095005937 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 882095005938 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 882095005939 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 882095005940 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 882095005941 putative L-serine binding site [chemical binding]; other site 882095005942 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 882095005943 DAK2 domain; Region: Dak2; pfam02734 882095005944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882095005945 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 882095005946 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 882095005947 Thiamine pyrophosphokinase; Region: TPK; cd07995 882095005948 active site 882095005949 dimerization interface [polypeptide binding]; other site 882095005950 thiamine binding site [chemical binding]; other site 882095005951 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882095005952 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882095005953 substrate binding site [chemical binding]; other site 882095005954 hexamer interface [polypeptide binding]; other site 882095005955 metal binding site [ion binding]; metal-binding site 882095005956 GTPase RsgA; Reviewed; Region: PRK00098 882095005957 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 882095005958 RNA binding site [nucleotide binding]; other site 882095005959 homodimer interface [polypeptide binding]; other site 882095005960 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882095005961 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882095005962 GTP/Mg2+ binding site [chemical binding]; other site 882095005963 G4 box; other site 882095005964 G1 box; other site 882095005965 Switch I region; other site 882095005966 G2 box; other site 882095005967 G3 box; other site 882095005968 Switch II region; other site 882095005969 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 882095005970 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882095005971 active site 882095005972 ATP binding site [chemical binding]; other site 882095005973 substrate binding site [chemical binding]; other site 882095005974 activation loop (A-loop); other site 882095005975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 882095005976 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882095005977 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882095005978 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882095005979 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 882095005980 Protein phosphatase 2C; Region: PP2C; pfam00481 882095005981 active site 882095005982 16S rRNA methyltransferase B; Provisional; Region: PRK14902 882095005983 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 882095005984 putative RNA binding site [nucleotide binding]; other site 882095005985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095005986 S-adenosylmethionine binding site [chemical binding]; other site 882095005987 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 882095005988 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 882095005989 putative active site [active] 882095005990 substrate binding site [chemical binding]; other site 882095005991 putative cosubstrate binding site; other site 882095005992 catalytic site [active] 882095005993 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 882095005994 substrate binding site [chemical binding]; other site 882095005995 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 882095005996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095005997 ATP binding site [chemical binding]; other site 882095005998 putative Mg++ binding site [ion binding]; other site 882095005999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095006000 ATP-binding site [chemical binding]; other site 882095006001 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 882095006002 Flavoprotein; Region: Flavoprotein; pfam02441 882095006003 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 882095006004 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 882095006005 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 882095006006 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 882095006007 catalytic site [active] 882095006008 G-X2-G-X-G-K; other site 882095006009 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 882095006010 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 882095006011 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 882095006012 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 882095006013 Domain of unknown function (DUF814); Region: DUF814; pfam05670 882095006014 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 882095006015 putative NAD(P) binding site [chemical binding]; other site 882095006016 homodimer interface [polypeptide binding]; other site 882095006017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095006018 active site 882095006019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 882095006020 active site 882095006021 dimer interface [polypeptide binding]; other site 882095006022 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 882095006023 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 882095006024 heterodimer interface [polypeptide binding]; other site 882095006025 active site 882095006026 FMN binding site [chemical binding]; other site 882095006027 homodimer interface [polypeptide binding]; other site 882095006028 substrate binding site [chemical binding]; other site 882095006029 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 882095006030 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 882095006031 FAD binding pocket [chemical binding]; other site 882095006032 FAD binding motif [chemical binding]; other site 882095006033 phosphate binding motif [ion binding]; other site 882095006034 beta-alpha-beta structure motif; other site 882095006035 NAD binding pocket [chemical binding]; other site 882095006036 Iron coordination center [ion binding]; other site 882095006037 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 882095006038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882095006039 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882095006040 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 882095006041 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882095006042 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882095006043 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 882095006044 IMP binding site; other site 882095006045 dimer interface [polypeptide binding]; other site 882095006046 interdomain contacts; other site 882095006047 partial ornithine binding site; other site 882095006048 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 882095006049 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 882095006050 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 882095006051 catalytic site [active] 882095006052 subunit interface [polypeptide binding]; other site 882095006053 dihydroorotase; Validated; Region: pyrC; PRK09357 882095006054 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882095006055 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 882095006056 active site 882095006057 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 882095006058 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882095006059 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882095006060 uracil transporter; Provisional; Region: PRK10720 882095006061 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882095006062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095006063 active site 882095006064 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 882095006065 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 882095006066 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882095006067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095006068 RNA binding surface [nucleotide binding]; other site 882095006069 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882095006070 active site 882095006071 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 882095006072 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882095006073 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882095006074 multidrug efflux protein; Reviewed; Region: PRK01766 882095006075 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 882095006076 cation binding site [ion binding]; other site 882095006077 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882095006078 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 882095006079 metal binding site [ion binding]; metal-binding site 882095006080 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882095006081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095006082 ABC-ATPase subunit interface; other site 882095006083 dimer interface [polypeptide binding]; other site 882095006084 putative PBP binding regions; other site 882095006085 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 882095006086 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882095006087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095006088 MarR family; Region: MarR; pfam01047 882095006089 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 882095006090 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 882095006091 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 882095006092 protein binding site [polypeptide binding]; other site 882095006093 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 882095006094 Catalytic dyad [active] 882095006095 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 882095006096 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882095006097 metal-binding site [ion binding] 882095006098 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 882095006099 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882095006100 metal-binding site [ion binding] 882095006101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095006102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095006103 motif II; other site 882095006104 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 882095006105 putative homodimer interface [polypeptide binding]; other site 882095006106 putative homotetramer interface [polypeptide binding]; other site 882095006107 putative allosteric switch controlling residues; other site 882095006108 putative metal binding site [ion binding]; other site 882095006109 putative homodimer-homodimer interface [polypeptide binding]; other site 882095006110 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 882095006111 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 882095006112 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 882095006113 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 882095006114 hypothetical protein; Provisional; Region: PRK13672 882095006115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095006116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095006117 methionine sulfoxide reductase B; Provisional; Region: PRK00222 882095006118 SelR domain; Region: SelR; pfam01641 882095006119 methionine sulfoxide reductase A; Provisional; Region: PRK14054 882095006120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 882095006121 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882095006122 active site 882095006123 catalytic triad [active] 882095006124 oxyanion hole [active] 882095006125 EDD domain protein, DegV family; Region: DegV; TIGR00762 882095006126 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882095006127 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 882095006128 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 882095006129 HTH domain; Region: HTH_11; pfam08279 882095006130 FOG: CBS domain [General function prediction only]; Region: COG0517 882095006131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 882095006132 PEP synthetase regulatory protein; Provisional; Region: PRK05339 882095006133 pyruvate phosphate dikinase; Provisional; Region: PRK09279 882095006134 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882095006135 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882095006136 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882095006137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095006138 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 882095006139 Predicted membrane protein [Function unknown]; Region: COG4129 882095006140 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882095006141 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 882095006142 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882095006143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882095006144 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 882095006145 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 882095006146 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 882095006147 Clostridial hydrophobic W; Region: ChW; pfam07538 882095006148 Clostridial hydrophobic W; Region: ChW; pfam07538 882095006149 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 882095006150 active site 882095006151 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882095006152 substrate binding site [chemical binding]; other site 882095006153 metal binding site [ion binding]; metal-binding site 882095006154 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 882095006155 Methyltransferase domain; Region: Methyltransf_18; pfam12847 882095006156 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882095006157 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 882095006158 folate binding site [chemical binding]; other site 882095006159 NADP+ binding site [chemical binding]; other site 882095006160 thymidylate synthase; Region: thym_sym; TIGR03284 882095006161 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 882095006162 dimerization interface [polypeptide binding]; other site 882095006163 active site 882095006164 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882095006165 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882095006166 Walker A/P-loop; other site 882095006167 ATP binding site [chemical binding]; other site 882095006168 Q-loop/lid; other site 882095006169 ABC transporter signature motif; other site 882095006170 Walker B; other site 882095006171 D-loop; other site 882095006172 H-loop/switch region; other site 882095006173 ABC transporter; Region: ABC_tran_2; pfam12848 882095006174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095006175 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 882095006176 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 882095006177 Potassium binding sites [ion binding]; other site 882095006178 Cesium cation binding sites [ion binding]; other site 882095006179 manganese transport transcriptional regulator; Provisional; Region: PRK03902 882095006180 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 882095006181 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 882095006182 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882095006183 DNA-binding site [nucleotide binding]; DNA binding site 882095006184 RNA-binding motif; other site 882095006185 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 882095006186 RNA/DNA hybrid binding site [nucleotide binding]; other site 882095006187 active site 882095006188 5'-3' exonuclease; Region: 53EXOc; smart00475 882095006189 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882095006190 active site 882095006191 metal binding site 1 [ion binding]; metal-binding site 882095006192 putative 5' ssDNA interaction site; other site 882095006193 metal binding site 3; metal-binding site 882095006194 metal binding site 2 [ion binding]; metal-binding site 882095006195 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882095006196 putative DNA binding site [nucleotide binding]; other site 882095006197 putative metal binding site [ion binding]; other site 882095006198 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 882095006199 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 882095006200 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 882095006201 putative active site [active] 882095006202 xanthine permease; Region: pbuX; TIGR03173 882095006203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095006204 active site 882095006205 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 882095006206 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 882095006207 active site 882095006208 Zn binding site [ion binding]; other site 882095006209 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 882095006210 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 882095006211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882095006212 cell division protein GpsB; Provisional; Region: PRK14127 882095006213 DivIVA domain; Region: DivI1A_domain; TIGR03544 882095006214 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 882095006215 hypothetical protein; Provisional; Region: PRK13660 882095006216 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 882095006217 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 882095006218 Transglycosylase; Region: Transgly; pfam00912 882095006219 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882095006220 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882095006221 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 882095006222 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882095006223 minor groove reading motif; other site 882095006224 helix-hairpin-helix signature motif; other site 882095006225 substrate binding pocket [chemical binding]; other site 882095006226 active site 882095006227 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 882095006228 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 882095006229 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882095006230 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 882095006231 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 882095006232 putative dimer interface [polypeptide binding]; other site 882095006233 putative anticodon binding site; other site 882095006234 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 882095006235 homodimer interface [polypeptide binding]; other site 882095006236 motif 1; other site 882095006237 motif 2; other site 882095006238 active site 882095006239 motif 3; other site 882095006240 aspartate aminotransferase; Provisional; Region: PRK05764 882095006241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095006242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095006243 homodimer interface [polypeptide binding]; other site 882095006244 catalytic residue [active] 882095006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 882095006246 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882095006247 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 882095006248 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882095006249 active site 882095006250 catalytic site [active] 882095006251 substrate binding site [chemical binding]; other site 882095006252 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 882095006253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882095006254 putative Mg++ binding site [ion binding]; other site 882095006255 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882095006256 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 882095006257 tetramerization interface [polypeptide binding]; other site 882095006258 active site 882095006259 pantoate--beta-alanine ligase; Region: panC; TIGR00018 882095006260 Pantoate-beta-alanine ligase; Region: PanC; cd00560 882095006261 active site 882095006262 ATP-binding site [chemical binding]; other site 882095006263 pantoate-binding site; other site 882095006264 HXXH motif; other site 882095006265 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 882095006266 active site 882095006267 oligomerization interface [polypeptide binding]; other site 882095006268 metal binding site [ion binding]; metal-binding site 882095006269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095006270 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882095006271 catalytic residues [active] 882095006272 Biotin operon repressor [Transcription]; Region: BirA; COG1654 882095006273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 882095006274 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 882095006275 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 882095006276 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 882095006277 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 882095006278 active site 882095006279 NTP binding site [chemical binding]; other site 882095006280 metal binding triad [ion binding]; metal-binding site 882095006281 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 882095006282 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 882095006283 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 882095006284 active site 882095006285 dimer interfaces [polypeptide binding]; other site 882095006286 catalytic residues [active] 882095006287 dihydrodipicolinate reductase; Provisional; Region: PRK00048 882095006288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 882095006289 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 882095006290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 882095006291 homodimer interface [polypeptide binding]; other site 882095006292 metal binding site [ion binding]; metal-binding site 882095006293 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882095006294 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095006295 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095006296 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095006297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 882095006298 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882095006299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882095006300 metal binding site [ion binding]; metal-binding site 882095006301 active site 882095006302 I-site; other site 882095006303 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882095006304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882095006305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882095006306 metal binding site [ion binding]; metal-binding site 882095006307 active site 882095006308 I-site; other site 882095006309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882095006310 malate dehydrogenase; Provisional; Region: PRK13529 882095006311 Malic enzyme, N-terminal domain; Region: malic; pfam00390 882095006312 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 882095006313 NAD(P) binding pocket [chemical binding]; other site 882095006314 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882095006315 Beta-lactamase; Region: Beta-lactamase; pfam00144 882095006316 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882095006317 Pyruvate formate lyase 1; Region: PFL1; cd01678 882095006318 coenzyme A binding site [chemical binding]; other site 882095006319 active site 882095006320 catalytic residues [active] 882095006321 glycine loop; other site 882095006322 HI0933-like protein; Region: HI0933_like; pfam03486 882095006323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095006324 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 882095006325 Predicted membrane protein [Function unknown]; Region: COG4347 882095006326 hypothetical protein; Provisional; Region: PRK03636 882095006327 UPF0302 domain; Region: UPF0302; pfam08864 882095006328 IDEAL domain; Region: IDEAL; pfam08858 882095006329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882095006330 binding surface 882095006331 TPR motif; other site 882095006332 TPR repeat; Region: TPR_11; pfam13414 882095006333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095006334 binding surface 882095006335 TPR motif; other site 882095006336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882095006337 binding surface 882095006338 TPR motif; other site 882095006339 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 882095006340 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 882095006341 hinge; other site 882095006342 active site 882095006343 prephenate dehydrogenase; Validated; Region: PRK06545 882095006344 prephenate dehydrogenase; Validated; Region: PRK08507 882095006345 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 882095006346 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 882095006347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095006348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095006349 homodimer interface [polypeptide binding]; other site 882095006350 catalytic residue [active] 882095006351 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 882095006352 homotrimer interaction site [polypeptide binding]; other site 882095006353 active site 882095006354 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 882095006355 active site 882095006356 dimer interface [polypeptide binding]; other site 882095006357 metal binding site [ion binding]; metal-binding site 882095006358 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 882095006359 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 882095006360 Tetramer interface [polypeptide binding]; other site 882095006361 active site 882095006362 FMN-binding site [chemical binding]; other site 882095006363 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 882095006364 active site 882095006365 multimer interface [polypeptide binding]; other site 882095006366 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882095006367 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882095006368 substrate binding pocket [chemical binding]; other site 882095006369 chain length determination region; other site 882095006370 substrate-Mg2+ binding site; other site 882095006371 catalytic residues [active] 882095006372 aspartate-rich region 1; other site 882095006373 active site lid residues [active] 882095006374 aspartate-rich region 2; other site 882095006375 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 882095006376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095006377 S-adenosylmethionine binding site [chemical binding]; other site 882095006378 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 882095006379 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 882095006380 homodecamer interface [polypeptide binding]; other site 882095006381 GTP cyclohydrolase I; Provisional; Region: PLN03044 882095006382 active site 882095006383 putative catalytic site residues [active] 882095006384 zinc binding site [ion binding]; other site 882095006385 GTP-CH-I/GFRP interaction surface; other site 882095006386 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 882095006387 IHF dimer interface [polypeptide binding]; other site 882095006388 IHF - DNA interface [nucleotide binding]; other site 882095006389 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882095006390 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882095006391 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 882095006392 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 882095006393 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 882095006394 GTP-binding protein Der; Reviewed; Region: PRK00093 882095006395 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 882095006396 G1 box; other site 882095006397 GTP/Mg2+ binding site [chemical binding]; other site 882095006398 Switch I region; other site 882095006399 G2 box; other site 882095006400 Switch II region; other site 882095006401 G3 box; other site 882095006402 G4 box; other site 882095006403 G5 box; other site 882095006404 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 882095006405 G1 box; other site 882095006406 GTP/Mg2+ binding site [chemical binding]; other site 882095006407 Switch I region; other site 882095006408 G2 box; other site 882095006409 G3 box; other site 882095006410 Switch II region; other site 882095006411 G4 box; other site 882095006412 G5 box; other site 882095006413 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 882095006414 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 882095006415 RNA binding site [nucleotide binding]; other site 882095006416 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 882095006417 RNA binding site [nucleotide binding]; other site 882095006418 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 882095006419 RNA binding site [nucleotide binding]; other site 882095006420 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882095006421 RNA binding site [nucleotide binding]; other site 882095006422 cytidylate kinase; Provisional; Region: cmk; PRK00023 882095006423 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 882095006424 CMP-binding site; other site 882095006425 The sites determining sugar specificity; other site 882095006426 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 882095006427 active site 882095006428 homotetramer interface [polypeptide binding]; other site 882095006429 homodimer interface [polypeptide binding]; other site 882095006430 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095006431 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 882095006432 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882095006433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095006434 ATP binding site [chemical binding]; other site 882095006435 putative Mg++ binding site [ion binding]; other site 882095006436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095006437 nucleotide binding region [chemical binding]; other site 882095006438 ATP-binding site [chemical binding]; other site 882095006439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 882095006440 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006441 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006442 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006443 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006444 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006445 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006446 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882095006447 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095006448 Predicted membrane protein [Function unknown]; Region: COG3601 882095006449 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882095006450 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 882095006451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095006452 dimerization interface [polypeptide binding]; other site 882095006453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 882095006454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095006455 dimer interface [polypeptide binding]; other site 882095006456 phosphorylation site [posttranslational modification] 882095006457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095006458 ATP binding site [chemical binding]; other site 882095006459 Mg2+ binding site [ion binding]; other site 882095006460 G-X-G motif; other site 882095006461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095006462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095006463 active site 882095006464 phosphorylation site [posttranslational modification] 882095006465 intermolecular recognition site; other site 882095006466 dimerization interface [polypeptide binding]; other site 882095006467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095006468 DNA binding site [nucleotide binding] 882095006469 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882095006470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095006471 RNA binding surface [nucleotide binding]; other site 882095006472 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 882095006473 active site 882095006474 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 882095006475 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 882095006476 diaminopimelate decarboxylase; Region: lysA; TIGR01048 882095006477 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 882095006478 active site 882095006479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882095006480 substrate binding site [chemical binding]; other site 882095006481 catalytic residues [active] 882095006482 dimer interface [polypeptide binding]; other site 882095006483 purine nucleoside phosphorylase; Provisional; Region: PRK08202 882095006484 phosphopentomutase; Provisional; Region: PRK05362 882095006485 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 882095006486 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 882095006487 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 882095006488 active site 882095006489 Int/Topo IB signature motif; other site 882095006490 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882095006491 metal binding site 2 [ion binding]; metal-binding site 882095006492 putative DNA binding helix; other site 882095006493 metal binding site 1 [ion binding]; metal-binding site 882095006494 dimer interface [polypeptide binding]; other site 882095006495 structural Zn2+ binding site [ion binding]; other site 882095006496 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882095006497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095006498 ABC-ATPase subunit interface; other site 882095006499 dimer interface [polypeptide binding]; other site 882095006500 putative PBP binding regions; other site 882095006501 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882095006502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095006503 ABC-ATPase subunit interface; other site 882095006504 dimer interface [polypeptide binding]; other site 882095006505 putative PBP binding regions; other site 882095006506 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 882095006507 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 882095006508 putative ligand binding residues [chemical binding]; other site 882095006509 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882095006510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882095006511 Walker A/P-loop; other site 882095006512 ATP binding site [chemical binding]; other site 882095006513 Q-loop/lid; other site 882095006514 ABC transporter signature motif; other site 882095006515 Walker B; other site 882095006516 D-loop; other site 882095006517 H-loop/switch region; other site 882095006518 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882095006519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095006520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095006521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095006522 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882095006523 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882095006524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095006525 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095006526 Walker B; other site 882095006527 D-loop; other site 882095006528 H-loop/switch region; other site 882095006529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095006530 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095006531 Walker A/P-loop; other site 882095006532 ATP binding site [chemical binding]; other site 882095006533 Q-loop/lid; other site 882095006534 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 882095006535 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 882095006536 dimer interface [polypeptide binding]; other site 882095006537 ADP-ribose binding site [chemical binding]; other site 882095006538 active site 882095006539 nudix motif; other site 882095006540 metal binding site [ion binding]; metal-binding site 882095006541 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 882095006542 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 882095006543 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 882095006544 active site 882095006545 DNA polymerase IV; Validated; Region: PRK02406 882095006546 DNA binding site [nucleotide binding] 882095006547 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 882095006548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882095006549 NAD(P) binding site [chemical binding]; other site 882095006550 active site 882095006551 ribonuclease Z; Region: RNase_Z; TIGR02651 882095006552 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 882095006553 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 882095006554 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 882095006555 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 882095006556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882095006557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095006558 Coenzyme A binding pocket [chemical binding]; other site 882095006559 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 882095006560 6-phosphogluconate dehydratase; Region: edd; TIGR01196 882095006561 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 882095006562 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882095006563 PYR/PP interface [polypeptide binding]; other site 882095006564 dimer interface [polypeptide binding]; other site 882095006565 TPP binding site [chemical binding]; other site 882095006566 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882095006567 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 882095006568 TPP-binding site [chemical binding]; other site 882095006569 dimer interface [polypeptide binding]; other site 882095006570 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 882095006571 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 882095006572 putative valine binding site [chemical binding]; other site 882095006573 dimer interface [polypeptide binding]; other site 882095006574 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 882095006575 ketol-acid reductoisomerase; Provisional; Region: PRK05479 882095006576 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 882095006577 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 882095006578 2-isopropylmalate synthase; Validated; Region: PRK00915 882095006579 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 882095006580 active site 882095006581 catalytic residues [active] 882095006582 metal binding site [ion binding]; metal-binding site 882095006583 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 882095006584 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 882095006585 tartrate dehydrogenase; Region: TTC; TIGR02089 882095006586 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 882095006587 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 882095006588 substrate binding site [chemical binding]; other site 882095006589 ligand binding site [chemical binding]; other site 882095006590 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 882095006591 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 882095006592 substrate binding site [chemical binding]; other site 882095006593 threonine dehydratase; Validated; Region: PRK08639 882095006594 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 882095006595 tetramer interface [polypeptide binding]; other site 882095006596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095006597 catalytic residue [active] 882095006598 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 882095006599 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 882095006600 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 882095006601 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882095006602 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882095006603 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 882095006604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095006605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095006606 DNA binding site [nucleotide binding] 882095006607 domain linker motif; other site 882095006608 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882095006609 dimerization interface [polypeptide binding]; other site 882095006610 ligand binding site [chemical binding]; other site 882095006611 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 882095006612 intersubunit interface [polypeptide binding]; other site 882095006613 active site 882095006614 catalytic residue [active] 882095006615 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882095006616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 882095006617 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882095006618 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882095006619 active pocket/dimerization site; other site 882095006620 active site 882095006621 phosphorylation site [posttranslational modification] 882095006622 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882095006623 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 882095006624 putative active site [active] 882095006625 SIS domain; Region: SIS; pfam01380 882095006626 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882095006627 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882095006628 dimer interface [polypeptide binding]; other site 882095006629 active site 882095006630 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882095006631 dimer interface [polypeptide binding]; other site 882095006632 active site 882095006633 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882095006634 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 882095006635 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882095006636 active site 882095006637 phosphorylation site [posttranslational modification] 882095006638 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095006639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095006640 DNA-binding site [nucleotide binding]; DNA binding site 882095006641 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882095006642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095006643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095006644 DNA-binding site [nucleotide binding]; DNA binding site 882095006645 UTRA domain; Region: UTRA; pfam07702 882095006646 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095006647 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095006648 active site 882095006649 catalytic tetrad [active] 882095006650 acetolactate synthase; Reviewed; Region: PRK08617 882095006651 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882095006652 PYR/PP interface [polypeptide binding]; other site 882095006653 dimer interface [polypeptide binding]; other site 882095006654 TPP binding site [chemical binding]; other site 882095006655 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882095006656 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 882095006657 TPP-binding site [chemical binding]; other site 882095006658 dimer interface [polypeptide binding]; other site 882095006659 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095006660 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 882095006661 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 882095006662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095006663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095006664 dimer interface [polypeptide binding]; other site 882095006665 conserved gate region; other site 882095006666 ABC-ATPase subunit interface; other site 882095006667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882095006668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095006669 dimer interface [polypeptide binding]; other site 882095006670 conserved gate region; other site 882095006671 ABC-ATPase subunit interface; other site 882095006672 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 882095006673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095006674 active site 882095006675 phosphorylation site [posttranslational modification] 882095006676 intermolecular recognition site; other site 882095006677 dimerization interface [polypeptide binding]; other site 882095006678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095006679 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882095006680 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 882095006681 dimerization interface [polypeptide binding]; other site 882095006682 Histidine kinase; Region: His_kinase; pfam06580 882095006683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095006684 ATP binding site [chemical binding]; other site 882095006685 Mg2+ binding site [ion binding]; other site 882095006686 G-X-G motif; other site 882095006687 Predicted integral membrane protein [Function unknown]; Region: COG5578 882095006688 Uncharacterized conserved protein [Function unknown]; Region: COG3538 882095006689 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 882095006690 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882095006691 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 882095006692 active site 882095006693 metal binding site [ion binding]; metal-binding site 882095006694 homodimer interface [polypeptide binding]; other site 882095006695 catalytic site [active] 882095006696 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882095006697 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882095006698 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 882095006699 active site 882095006700 catalytic site [active] 882095006701 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882095006702 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882095006703 DNA-binding site [nucleotide binding]; DNA binding site 882095006704 RNA-binding motif; other site 882095006705 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882095006706 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882095006707 active site 882095006708 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 882095006709 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882095006710 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882095006711 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 882095006712 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 882095006713 active site 882095006714 HIGH motif; other site 882095006715 nucleotide binding site [chemical binding]; other site 882095006716 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 882095006717 active site 882095006718 KMSKS motif; other site 882095006719 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 882095006720 tRNA binding surface [nucleotide binding]; other site 882095006721 anticodon binding site; other site 882095006722 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882095006723 DivIVA protein; Region: DivIVA; pfam05103 882095006724 DivIVA domain; Region: DivI1A_domain; TIGR03544 882095006725 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 882095006726 HTH domain; Region: HTH_11; pfam08279 882095006727 3H domain; Region: 3H; pfam02829 882095006728 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882095006729 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882095006730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095006731 catalytic residue [active] 882095006732 L-aspartate oxidase; Provisional; Region: PRK08071 882095006733 L-aspartate oxidase; Provisional; Region: PRK06175 882095006734 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 882095006735 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 882095006736 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 882095006737 dimerization interface [polypeptide binding]; other site 882095006738 active site 882095006739 quinolinate synthetase; Provisional; Region: PRK09375 882095006740 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006741 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095006742 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006743 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006744 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006745 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095006746 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006747 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006748 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095006749 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006750 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095006751 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006752 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006753 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006754 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006755 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882095006756 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006757 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006758 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006759 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882095006760 Leucine rich repeat; Region: LRR_8; pfam13855 882095006761 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882095006762 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095006763 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882095006764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095006765 S-adenosylmethionine binding site [chemical binding]; other site 882095006766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095006767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095006768 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 882095006769 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095006770 RNA binding surface [nucleotide binding]; other site 882095006771 YGGT family; Region: YGGT; pfam02325 882095006772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 882095006773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 882095006774 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882095006775 catalytic residue [active] 882095006776 cell division protein FtsZ; Validated; Region: PRK09330 882095006777 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 882095006778 nucleotide binding site [chemical binding]; other site 882095006779 SulA interaction site; other site 882095006780 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 882095006781 Cell division protein FtsA; Region: FtsA; smart00842 882095006782 Cell division protein FtsA; Region: FtsA; pfam14450 882095006783 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 882095006784 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 882095006785 Cell division protein FtsQ; Region: FtsQ; pfam03799 882095006786 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 882095006787 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 882095006788 active site 882095006789 homodimer interface [polypeptide binding]; other site 882095006790 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 882095006791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882095006792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882095006793 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 882095006794 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 882095006795 Mg++ binding site [ion binding]; other site 882095006796 putative catalytic motif [active] 882095006797 putative substrate binding site [chemical binding]; other site 882095006798 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 882095006799 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882095006800 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882095006801 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882095006802 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882095006803 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882095006804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882095006805 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 882095006806 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 882095006807 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 882095006808 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 882095006809 MraW methylase family; Region: Methyltransf_5; pfam01795 882095006810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 882095006811 MraZ protein; Region: MraZ; pfam02381 882095006812 MraZ protein; Region: MraZ; pfam02381 882095006813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095006814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095006815 putative substrate translocation pore; other site 882095006816 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 882095006817 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 882095006818 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 882095006819 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 882095006820 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 882095006821 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 882095006822 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 882095006823 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 882095006824 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 882095006825 hypothetical protein; Provisional; Region: PRK13670 882095006826 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882095006827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882095006828 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 882095006829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095006830 Walker A/P-loop; other site 882095006831 ATP binding site [chemical binding]; other site 882095006832 Q-loop/lid; other site 882095006833 ABC transporter signature motif; other site 882095006834 Walker B; other site 882095006835 D-loop; other site 882095006836 H-loop/switch region; other site 882095006837 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 882095006838 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 882095006839 protein binding site [polypeptide binding]; other site 882095006840 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 882095006841 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 882095006842 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 882095006843 active site 882095006844 (T/H)XGH motif; other site 882095006845 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 882095006846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095006847 S-adenosylmethionine binding site [chemical binding]; other site 882095006848 hypothetical protein; Provisional; Region: PRK02886 882095006849 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 882095006850 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 882095006851 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 882095006852 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 882095006853 UbiA prenyltransferase family; Region: UbiA; pfam01040 882095006854 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 882095006855 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 882095006856 Ion transport protein; Region: Ion_trans; pfam00520 882095006857 Ion channel; Region: Ion_trans_2; pfam07885 882095006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 882095006859 MOSC domain; Region: MOSC; pfam03473 882095006860 3-alpha domain; Region: 3-alpha; pfam03475 882095006861 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 882095006862 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 882095006863 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 882095006864 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 882095006865 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 882095006866 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 882095006867 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 882095006868 active site 882095006869 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 882095006870 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 882095006871 ring oligomerisation interface [polypeptide binding]; other site 882095006872 ATP/Mg binding site [chemical binding]; other site 882095006873 stacking interactions; other site 882095006874 hinge regions; other site 882095006875 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 882095006876 oligomerisation interface [polypeptide binding]; other site 882095006877 mobile loop; other site 882095006878 roof hairpin; other site 882095006879 CAAX protease self-immunity; Region: Abi; pfam02517 882095006880 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 882095006881 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 882095006882 CoA binding domain; Region: CoA_binding; pfam02629 882095006883 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882095006884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095006885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095006886 ABC transporter; Region: ABC_tran_2; pfam12848 882095006887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095006888 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095006889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882095006890 UGMP family protein; Validated; Region: PRK09604 882095006891 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882095006892 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882095006893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095006894 Coenzyme A binding pocket [chemical binding]; other site 882095006895 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882095006896 Glycoprotease family; Region: Peptidase_M22; pfam00814 882095006897 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 882095006898 camphor resistance protein CrcB; Provisional; Region: PRK14214 882095006899 camphor resistance protein CrcB; Provisional; Region: PRK14231 882095006900 Uncharacterized conserved protein [Function unknown]; Region: COG4832 882095006901 Phosphotransferase enzyme family; Region: APH; pfam01636 882095006902 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882095006903 active site 882095006904 substrate binding site [chemical binding]; other site 882095006905 ATP binding site [chemical binding]; other site 882095006906 Cna protein B-type domain; Region: Cna_B; pfam05738 882095006907 Cna protein B-type domain; Region: Cna_B; pfam05738 882095006908 Cna protein B-type domain; Region: Cna_B; pfam05738 882095006909 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095006910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095006911 non-specific DNA binding site [nucleotide binding]; other site 882095006912 salt bridge; other site 882095006913 sequence-specific DNA binding site [nucleotide binding]; other site 882095006914 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 882095006915 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882095006916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095006917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095006918 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882095006919 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882095006920 substrate binding pocket [chemical binding]; other site 882095006921 argininosuccinate synthase; Provisional; Region: PRK13820 882095006922 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 882095006923 ANP binding site [chemical binding]; other site 882095006924 Substrate Binding Site II [chemical binding]; other site 882095006925 Substrate Binding Site I [chemical binding]; other site 882095006926 argininosuccinate lyase; Provisional; Region: PRK00855 882095006927 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 882095006928 active sites [active] 882095006929 tetramer interface [polypeptide binding]; other site 882095006930 BCCT family transporter; Region: BCCT; pfam02028 882095006931 hypothetical protein; Provisional; Region: PRK06357 882095006932 active site 882095006933 intersubunit interface [polypeptide binding]; other site 882095006934 Zn2+ binding site [ion binding]; other site 882095006935 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882095006936 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882095006937 putative substrate binding site [chemical binding]; other site 882095006938 putative ATP binding site [chemical binding]; other site 882095006939 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882095006940 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882095006941 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882095006942 active site 882095006943 P-loop; other site 882095006944 phosphorylation site [posttranslational modification] 882095006945 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095006946 active site 882095006947 phosphorylation site [posttranslational modification] 882095006948 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095006949 PRD domain; Region: PRD; pfam00874 882095006950 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095006951 active site 882095006952 P-loop; other site 882095006953 phosphorylation site [posttranslational modification] 882095006954 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 882095006955 active site 882095006956 phosphorylation site [posttranslational modification] 882095006957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 882095006958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095006959 DNA-binding site [nucleotide binding]; DNA binding site 882095006960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095006961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095006962 homodimer interface [polypeptide binding]; other site 882095006963 catalytic residue [active] 882095006964 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 882095006965 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 882095006966 active site 882095006967 multimer interface [polypeptide binding]; other site 882095006968 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 882095006969 conserved cys residue [active] 882095006970 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 882095006971 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 882095006972 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 882095006973 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 882095006974 G1 box; other site 882095006975 GTP/Mg2+ binding site [chemical binding]; other site 882095006976 Switch I region; other site 882095006977 G2 box; other site 882095006978 G3 box; other site 882095006979 Switch II region; other site 882095006980 G4 box; other site 882095006981 G5 box; other site 882095006982 Nucleoside recognition; Region: Gate; pfam07670 882095006983 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 882095006984 Nucleoside recognition; Region: Gate; pfam07670 882095006985 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882095006986 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882095006987 putative active site [active] 882095006988 putative metal binding site [ion binding]; other site 882095006989 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095006990 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882095006991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095006992 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882095006993 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882095006994 active site 882095006995 dimer interface [polypeptide binding]; other site 882095006996 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882095006997 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882095006998 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 882095006999 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882095007000 dimer interface [polypeptide binding]; other site 882095007001 FMN binding site [chemical binding]; other site 882095007002 NADPH bind site [chemical binding]; other site 882095007003 Helix-turn-helix domain; Region: HTH_17; pfam12728 882095007004 putative heme peroxidase; Provisional; Region: PRK12276 882095007005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095007006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095007007 Walker A/P-loop; other site 882095007008 ATP binding site [chemical binding]; other site 882095007009 Q-loop/lid; other site 882095007010 ABC transporter signature motif; other site 882095007011 Walker B; other site 882095007012 D-loop; other site 882095007013 H-loop/switch region; other site 882095007014 FtsX-like permease family; Region: FtsX; pfam02687 882095007015 FtsX-like permease family; Region: FtsX; pfam02687 882095007016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095007017 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095007018 Coenzyme A binding pocket [chemical binding]; other site 882095007019 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 882095007020 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 882095007021 active site 882095007022 substrate binding site [chemical binding]; other site 882095007023 metal binding site [ion binding]; metal-binding site 882095007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 882095007025 YbbR-like protein; Region: YbbR; pfam07949 882095007026 YbbR-like protein; Region: YbbR; pfam07949 882095007027 YbbR-like protein; Region: YbbR; pfam07949 882095007028 Uncharacterized conserved protein [Function unknown]; Region: COG1624 882095007029 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 882095007030 maltose phosphorylase; Provisional; Region: PRK13807 882095007031 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882095007032 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882095007033 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 882095007034 Predicted integral membrane protein [Function unknown]; Region: COG5521 882095007035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095007036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007037 dimer interface [polypeptide binding]; other site 882095007038 conserved gate region; other site 882095007039 putative PBP binding loops; other site 882095007040 ABC-ATPase subunit interface; other site 882095007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007042 dimer interface [polypeptide binding]; other site 882095007043 conserved gate region; other site 882095007044 putative PBP binding loops; other site 882095007045 ABC-ATPase subunit interface; other site 882095007046 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 882095007047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095007048 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 882095007049 homodimer interface [polypeptide binding]; other site 882095007050 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 882095007051 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 882095007052 active site 882095007053 homodimer interface [polypeptide binding]; other site 882095007054 catalytic site [active] 882095007055 CAAX protease self-immunity; Region: Abi; cl00558 882095007056 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095007057 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095007058 DNA binding site [nucleotide binding] 882095007059 domain linker motif; other site 882095007060 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882095007061 ligand binding site [chemical binding]; other site 882095007062 dimerization interface [polypeptide binding]; other site 882095007063 Amino acid permease; Region: AA_permease_2; pfam13520 882095007064 K+ potassium transporter; Region: K_trans; cl15781 882095007065 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095007066 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095007067 ligand binding site [chemical binding]; other site 882095007068 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095007069 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095007070 ligand binding site [chemical binding]; other site 882095007071 flexible hinge region; other site 882095007072 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095007073 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882095007074 intersubunit interface [polypeptide binding]; other site 882095007075 active site 882095007076 zinc binding site [ion binding]; other site 882095007077 Na+ binding site [ion binding]; other site 882095007078 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882095007079 intersubunit interface [polypeptide binding]; other site 882095007080 active site 882095007081 zinc binding site [ion binding]; other site 882095007082 Na+ binding site [ion binding]; other site 882095007083 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095007084 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095007085 active site 882095007086 P-loop; other site 882095007087 phosphorylation site [posttranslational modification] 882095007088 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095007089 active site 882095007090 phosphorylation site [posttranslational modification] 882095007091 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095007092 HTH domain; Region: HTH_11; pfam08279 882095007093 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095007094 PRD domain; Region: PRD; pfam00874 882095007095 PRD domain; Region: PRD; pfam00874 882095007096 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095007097 active site 882095007098 P-loop; other site 882095007099 phosphorylation site [posttranslational modification] 882095007100 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 882095007101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095007102 Walker A/P-loop; other site 882095007103 ATP binding site [chemical binding]; other site 882095007104 Q-loop/lid; other site 882095007105 ABC transporter signature motif; other site 882095007106 Walker B; other site 882095007107 D-loop; other site 882095007108 H-loop/switch region; other site 882095007109 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 882095007110 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 882095007111 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882095007112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095007113 Coenzyme A binding pocket [chemical binding]; other site 882095007114 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882095007115 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882095007116 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 882095007117 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882095007118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095007119 DNA-binding site [nucleotide binding]; DNA binding site 882095007120 UTRA domain; Region: UTRA; pfam07702 882095007121 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 882095007122 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 882095007123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095007124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095007125 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 882095007126 putative dimerization interface [polypeptide binding]; other site 882095007127 Predicted membrane protein [Function unknown]; Region: COG2855 882095007128 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 882095007129 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 882095007130 putative metal binding site [ion binding]; other site 882095007131 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 882095007132 homodimer interface [polypeptide binding]; other site 882095007133 chemical substrate binding site [chemical binding]; other site 882095007134 oligomer interface [polypeptide binding]; other site 882095007135 metal binding site [ion binding]; metal-binding site 882095007136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095007137 catalytic residues [active] 882095007138 flavodoxin; Provisional; Region: PRK09271 882095007139 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 882095007140 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 882095007141 dimer interface [polypeptide binding]; other site 882095007142 putative radical transfer pathway; other site 882095007143 diiron center [ion binding]; other site 882095007144 tyrosyl radical; other site 882095007145 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 882095007146 Class I ribonucleotide reductase; Region: RNR_I; cd01679 882095007147 active site 882095007148 dimer interface [polypeptide binding]; other site 882095007149 catalytic residues [active] 882095007150 effector binding site; other site 882095007151 R2 peptide binding site; other site 882095007152 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 882095007153 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 882095007154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882095007155 SCP-2 sterol transfer family; Region: SCP2; cl01225 882095007156 CsbD-like; Region: CsbD; cl17424 882095007157 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095007158 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095007159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882095007160 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882095007161 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 882095007162 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 882095007163 conserved cys residue [active] 882095007164 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882095007165 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095007166 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095007167 Cupin; Region: Cupin_1; pfam00190 882095007168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095007169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095007170 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095007171 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095007172 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095007173 ligand binding site [chemical binding]; other site 882095007174 flexible hinge region; other site 882095007175 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 882095007176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882095007177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095007178 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 882095007179 dimer interface [polypeptide binding]; other site 882095007180 active site 882095007181 metal binding site [ion binding]; metal-binding site 882095007182 glutathione binding site [chemical binding]; other site 882095007183 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882095007184 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882095007185 FMN binding site [chemical binding]; other site 882095007186 substrate binding site [chemical binding]; other site 882095007187 putative catalytic residue [active] 882095007188 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 882095007189 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 882095007190 Coenzyme A transferase; Region: CoA_trans; smart00882 882095007191 Coenzyme A transferase; Region: CoA_trans; cl17247 882095007192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095007193 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 882095007194 Walker A motif; other site 882095007195 ATP binding site [chemical binding]; other site 882095007196 Walker B motif; other site 882095007197 arginine finger; other site 882095007198 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 882095007199 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882095007200 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882095007201 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882095007202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882095007203 metal binding site [ion binding]; metal-binding site 882095007204 active site 882095007205 I-site; other site 882095007206 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882095007207 classical (c) SDRs; Region: SDR_c; cd05233 882095007208 NAD(P) binding site [chemical binding]; other site 882095007209 active site 882095007210 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 882095007211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095007212 Tic20-like protein; Region: Tic20; pfam09685 882095007213 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882095007214 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007215 Collagen binding domain; Region: Collagen_bind; pfam05737 882095007216 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007217 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007218 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007219 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007220 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007221 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882095007222 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007223 Collagen binding domain; Region: Collagen_bind; pfam05737 882095007224 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007225 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007226 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007227 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007228 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007229 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007230 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007231 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095007232 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007233 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007234 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095007235 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 882095007236 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 882095007237 active site 882095007238 catalytic site [active] 882095007239 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882095007240 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882095007241 Walker A/P-loop; other site 882095007242 ATP binding site [chemical binding]; other site 882095007243 Q-loop/lid; other site 882095007244 ABC transporter signature motif; other site 882095007245 Walker B; other site 882095007246 D-loop; other site 882095007247 H-loop/switch region; other site 882095007248 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 882095007249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095007250 ABC-ATPase subunit interface; other site 882095007251 dimer interface [polypeptide binding]; other site 882095007252 putative PBP binding regions; other site 882095007253 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 882095007254 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882095007255 intersubunit interface [polypeptide binding]; other site 882095007256 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882095007257 heme-binding site [chemical binding]; other site 882095007258 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 882095007259 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882095007260 heme-binding site [chemical binding]; other site 882095007261 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882095007262 heme-binding site [chemical binding]; other site 882095007263 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882095007264 heme uptake protein IsdC; Region: IsdC; TIGR03656 882095007265 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882095007266 heme-binding site [chemical binding]; other site 882095007267 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882095007268 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882095007269 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 882095007270 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 882095007271 active site 882095007272 Zn binding site [ion binding]; other site 882095007273 Competence protein CoiA-like family; Region: CoiA; cl11541 882095007274 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 882095007275 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 882095007276 ArsC family; Region: ArsC; pfam03960 882095007277 putative catalytic residues [active] 882095007278 thiol/disulfide switch; other site 882095007279 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 882095007280 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882095007281 Walker A/P-loop; other site 882095007282 ATP binding site [chemical binding]; other site 882095007283 Q-loop/lid; other site 882095007284 ABC transporter signature motif; other site 882095007285 Walker B; other site 882095007286 D-loop; other site 882095007287 H-loop/switch region; other site 882095007288 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882095007289 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 882095007290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882095007291 Walker A/P-loop; other site 882095007292 ATP binding site [chemical binding]; other site 882095007293 Q-loop/lid; other site 882095007294 ABC transporter signature motif; other site 882095007295 Walker B; other site 882095007296 D-loop; other site 882095007297 H-loop/switch region; other site 882095007298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882095007299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882095007300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007301 dimer interface [polypeptide binding]; other site 882095007302 conserved gate region; other site 882095007303 putative PBP binding loops; other site 882095007304 ABC-ATPase subunit interface; other site 882095007305 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882095007306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007307 dimer interface [polypeptide binding]; other site 882095007308 conserved gate region; other site 882095007309 putative PBP binding loops; other site 882095007310 ABC-ATPase subunit interface; other site 882095007311 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882095007312 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882095007313 peptide binding site [polypeptide binding]; other site 882095007314 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 882095007315 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 882095007316 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 882095007317 active site 882095007318 HIGH motif; other site 882095007319 dimer interface [polypeptide binding]; other site 882095007320 KMSKS motif; other site 882095007321 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 882095007322 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095007323 MarR family; Region: MarR; pfam01047 882095007324 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 882095007325 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 882095007326 dimer interface [polypeptide binding]; other site 882095007327 active site 882095007328 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 882095007329 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 882095007330 dimer interface [polypeptide binding]; other site 882095007331 active site 882095007332 CoA binding pocket [chemical binding]; other site 882095007333 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095007334 SH3-like domain; Region: SH3_8; pfam13457 882095007335 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 882095007336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095007337 catalytic core [active] 882095007338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882095007339 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 882095007340 Clp amino terminal domain; Region: Clp_N; pfam02861 882095007341 Clp amino terminal domain; Region: Clp_N; pfam02861 882095007342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095007343 Walker A motif; other site 882095007344 ATP binding site [chemical binding]; other site 882095007345 Walker B motif; other site 882095007346 arginine finger; other site 882095007347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095007348 Walker A motif; other site 882095007349 ATP binding site [chemical binding]; other site 882095007350 Walker B motif; other site 882095007351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882095007352 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 882095007353 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 882095007354 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095007355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095007356 active site 882095007357 motif I; other site 882095007358 motif II; other site 882095007359 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882095007360 Predicted acetyltransferase [General function prediction only]; Region: COG3393 882095007361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 882095007362 ferrochelatase; Provisional; Region: PRK12435 882095007363 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 882095007364 C-terminal domain interface [polypeptide binding]; other site 882095007365 active site 882095007366 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 882095007367 active site 882095007368 N-terminal domain interface [polypeptide binding]; other site 882095007369 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 882095007370 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 882095007371 substrate binding site [chemical binding]; other site 882095007372 active site 882095007373 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 882095007374 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 882095007375 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882095007376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095007377 Walker A/P-loop; other site 882095007378 ATP binding site [chemical binding]; other site 882095007379 Q-loop/lid; other site 882095007380 ABC transporter signature motif; other site 882095007381 Walker B; other site 882095007382 D-loop; other site 882095007383 H-loop/switch region; other site 882095007384 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 882095007385 HIT family signature motif; other site 882095007386 catalytic residue [active] 882095007387 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882095007388 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882095007389 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882095007390 SurA N-terminal domain; Region: SurA_N_3; cl07813 882095007391 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882095007392 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 882095007393 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 882095007394 generic binding surface II; other site 882095007395 generic binding surface I; other site 882095007396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095007397 Zn2+ binding site [ion binding]; other site 882095007398 Mg2+ binding site [ion binding]; other site 882095007399 Uncharacterized conserved protein [Function unknown]; Region: COG4717 882095007400 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882095007401 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882095007402 active site 882095007403 metal binding site [ion binding]; metal-binding site 882095007404 DNA binding site [nucleotide binding] 882095007405 hypothetical protein; Provisional; Region: PRK13676 882095007406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 882095007407 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 882095007408 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 882095007409 Int/Topo IB signature motif; other site 882095007410 Helix-turn-helix domain; Region: HTH_16; pfam12645 882095007411 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 882095007412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882095007413 DNA binding residues [nucleotide binding] 882095007414 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 882095007415 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 882095007416 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 882095007417 P loop; other site 882095007418 Nucleotide binding site [chemical binding]; other site 882095007419 DTAP/Switch II; other site 882095007420 Switch I; other site 882095007421 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 882095007422 P loop; other site 882095007423 Nucleotide binding site [chemical binding]; other site 882095007424 DTAP/Switch II; other site 882095007425 Switch I; other site 882095007426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095007427 dimerization interface [polypeptide binding]; other site 882095007428 putative DNA binding site [nucleotide binding]; other site 882095007429 putative Zn2+ binding site [ion binding]; other site 882095007430 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 882095007431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095007432 dimerization interface [polypeptide binding]; other site 882095007433 putative DNA binding site [nucleotide binding]; other site 882095007434 putative Zn2+ binding site [ion binding]; other site 882095007435 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 882095007436 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 882095007437 P loop; other site 882095007438 Nucleotide binding site [chemical binding]; other site 882095007439 DTAP/Switch II; other site 882095007440 Switch I; other site 882095007441 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 882095007442 DTAP/Switch II; other site 882095007443 Switch I; other site 882095007444 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 882095007445 arsenical-resistance protein; Region: acr3; TIGR00832 882095007446 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 882095007447 arsenical-resistance protein; Region: acr3; TIGR00832 882095007448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095007449 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 882095007450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095007451 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882095007452 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 882095007453 active site residue [active] 882095007454 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095007455 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095007456 Walker A/P-loop; other site 882095007457 ATP binding site [chemical binding]; other site 882095007458 Q-loop/lid; other site 882095007459 ABC transporter signature motif; other site 882095007460 Walker B; other site 882095007461 D-loop; other site 882095007462 H-loop/switch region; other site 882095007463 inner membrane transport permease; Provisional; Region: PRK15066 882095007464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882095007465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095007466 putative DNA binding site [nucleotide binding]; other site 882095007467 dimerization interface [polypeptide binding]; other site 882095007468 putative Zn2+ binding site [ion binding]; other site 882095007469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 882095007470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882095007471 metal-binding site [ion binding] 882095007472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095007473 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882095007474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 882095007475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 882095007476 catalytic residue [active] 882095007477 TIGR02594 family protein; Region: TIGR02594 882095007478 AAA-like domain; Region: AAA_10; pfam12846 882095007479 TcpE family; Region: TcpE; pfam12648 882095007480 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 882095007481 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 882095007482 Antirestriction protein (ArdA); Region: ArdA; cl01953 882095007483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095007484 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882095007485 non-specific DNA binding site [nucleotide binding]; other site 882095007486 salt bridge; other site 882095007487 sequence-specific DNA binding site [nucleotide binding]; other site 882095007488 Replication initiation factor; Region: Rep_trans; pfam02486 882095007489 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882095007490 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882095007491 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 882095007492 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007493 Cna protein B-type domain; Region: Cna_B; pfam05738 882095007494 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 882095007495 TIGR03545 family protein; Region: TIGR03545 882095007496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 882095007497 fumarate hydratase; Reviewed; Region: fumC; PRK00485 882095007498 Class II fumarases; Region: Fumarase_classII; cd01362 882095007499 active site 882095007500 tetramer interface [polypeptide binding]; other site 882095007501 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 882095007502 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095007503 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095007504 Walker A/P-loop; other site 882095007505 ATP binding site [chemical binding]; other site 882095007506 Q-loop/lid; other site 882095007507 ABC transporter signature motif; other site 882095007508 Walker B; other site 882095007509 D-loop; other site 882095007510 H-loop/switch region; other site 882095007511 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882095007512 Transglycosylase; Region: Transgly; pfam00912 882095007513 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882095007514 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882095007515 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882095007516 Low molecular weight phosphatase family; Region: LMWPc; cl00105 882095007517 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882095007518 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882095007519 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882095007520 Domain of unknown function DUF21; Region: DUF21; pfam01595 882095007521 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882095007522 Transporter associated domain; Region: CorC_HlyC; smart01091 882095007523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095007524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095007525 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882095007526 putative dimerization interface [polypeptide binding]; other site 882095007527 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882095007528 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 882095007529 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882095007530 active site 882095007531 FMN binding site [chemical binding]; other site 882095007532 substrate binding site [chemical binding]; other site 882095007533 putative catalytic residue [active] 882095007534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095007535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095007536 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882095007537 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882095007538 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882095007539 shikimate binding site; other site 882095007540 NAD(P) binding site [chemical binding]; other site 882095007541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095007542 putative substrate translocation pore; other site 882095007543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095007545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095007546 putative substrate translocation pore; other site 882095007547 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882095007548 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095007549 Walker A/P-loop; other site 882095007550 ATP binding site [chemical binding]; other site 882095007551 Q-loop/lid; other site 882095007552 ABC transporter signature motif; other site 882095007553 Walker B; other site 882095007554 D-loop; other site 882095007555 H-loop/switch region; other site 882095007556 Predicted transcriptional regulators [Transcription]; Region: COG1725 882095007557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882095007558 DNA-binding site [nucleotide binding]; DNA binding site 882095007559 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882095007560 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882095007561 DNA binding site [nucleotide binding] 882095007562 active site 882095007563 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882095007564 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882095007565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095007566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095007567 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882095007568 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882095007569 active site 882095007570 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 882095007571 putative dimer interface [polypeptide binding]; other site 882095007572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095007573 ligand binding site [chemical binding]; other site 882095007574 Zn binding site [ion binding]; other site 882095007575 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882095007576 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 882095007577 active site 882095007578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095007579 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095007580 active site 882095007581 catalytic tetrad [active] 882095007582 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 882095007583 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882095007584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882095007585 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882095007586 substrate binding pocket [chemical binding]; other site 882095007587 membrane-bound complex binding site; other site 882095007588 hinge residues; other site 882095007589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882095007590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007591 dimer interface [polypeptide binding]; other site 882095007592 conserved gate region; other site 882095007593 putative PBP binding loops; other site 882095007594 ABC-ATPase subunit interface; other site 882095007595 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882095007596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882095007597 Walker A/P-loop; other site 882095007598 ATP binding site [chemical binding]; other site 882095007599 Q-loop/lid; other site 882095007600 ABC transporter signature motif; other site 882095007601 Walker B; other site 882095007602 D-loop; other site 882095007603 H-loop/switch region; other site 882095007604 aspartate aminotransferase; Provisional; Region: PRK06348 882095007605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095007606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095007607 homodimer interface [polypeptide binding]; other site 882095007608 catalytic residue [active] 882095007609 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882095007610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095007611 motif II; other site 882095007612 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882095007613 intracellular protease, PfpI family; Region: PfpI; TIGR01382 882095007614 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 882095007615 proposed catalytic triad [active] 882095007616 conserved cys residue [active] 882095007617 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095007618 methionine cluster; other site 882095007619 active site 882095007620 phosphorylation site [posttranslational modification] 882095007621 metal binding site [ion binding]; metal-binding site 882095007622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095007623 Coenzyme A binding pocket [chemical binding]; other site 882095007624 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095007625 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 882095007626 esterase; Provisional; Region: PRK10566 882095007627 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882095007628 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095007629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882095007630 motif II; other site 882095007631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095007632 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882095007633 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095007634 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095007635 hypothetical protein; Provisional; Region: PRK13673 882095007636 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 882095007637 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 882095007638 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 882095007639 Family description; Region: UvrD_C_2; pfam13538 882095007640 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882095007641 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 882095007642 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882095007643 IDEAL domain; Region: IDEAL; pfam08858 882095007644 ComK protein; Region: ComK; cl11560 882095007645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882095007646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095007647 non-specific DNA binding site [nucleotide binding]; other site 882095007648 salt bridge; other site 882095007649 sequence-specific DNA binding site [nucleotide binding]; other site 882095007650 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882095007651 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095007652 active site 882095007653 phosphorylation site [posttranslational modification] 882095007654 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095007655 active site 882095007656 P-loop; other site 882095007657 phosphorylation site [posttranslational modification] 882095007658 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095007659 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882095007660 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882095007661 putative substrate binding site [chemical binding]; other site 882095007662 putative ATP binding site [chemical binding]; other site 882095007663 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095007664 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882095007665 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095007666 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 882095007667 trimer interface [polypeptide binding]; other site 882095007668 active site 882095007669 G bulge; other site 882095007670 Uncharacterized conserved protein [Function unknown]; Region: COG1683 882095007671 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 882095007672 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882095007673 non-specific DNA interactions [nucleotide binding]; other site 882095007674 DNA binding site [nucleotide binding] 882095007675 sequence specific DNA binding site [nucleotide binding]; other site 882095007676 putative cAMP binding site [chemical binding]; other site 882095007677 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 882095007678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882095007679 substrate binding site [chemical binding]; other site 882095007680 ATP binding site [chemical binding]; other site 882095007681 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882095007682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882095007683 RNA binding surface [nucleotide binding]; other site 882095007684 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 882095007685 active site 882095007686 uracil binding [chemical binding]; other site 882095007687 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 882095007688 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 882095007689 active site 882095007690 non-prolyl cis peptide bond; other site 882095007691 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 882095007692 catalytic residues [active] 882095007693 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 882095007694 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 882095007695 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882095007696 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882095007697 Walker A/P-loop; other site 882095007698 ATP binding site [chemical binding]; other site 882095007699 Q-loop/lid; other site 882095007700 ABC transporter signature motif; other site 882095007701 Walker B; other site 882095007702 D-loop; other site 882095007703 H-loop/switch region; other site 882095007704 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882095007705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007706 dimer interface [polypeptide binding]; other site 882095007707 conserved gate region; other site 882095007708 putative PBP binding loops; other site 882095007709 ABC-ATPase subunit interface; other site 882095007710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882095007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007712 dimer interface [polypeptide binding]; other site 882095007713 conserved gate region; other site 882095007714 putative PBP binding loops; other site 882095007715 ABC-ATPase subunit interface; other site 882095007716 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882095007717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882095007718 substrate binding pocket [chemical binding]; other site 882095007719 membrane-bound complex binding site; other site 882095007720 hinge residues; other site 882095007721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095007722 Coenzyme A binding pocket [chemical binding]; other site 882095007723 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882095007724 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882095007725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882095007726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882095007727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882095007728 dimerization interface [polypeptide binding]; other site 882095007729 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882095007730 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 882095007731 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 882095007732 active site 882095007733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095007734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095007735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095007736 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882095007737 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882095007738 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882095007739 active site 882095007740 trimer interface [polypeptide binding]; other site 882095007741 allosteric site; other site 882095007742 active site lid [active] 882095007743 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882095007744 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095007745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882095007746 Predicted membrane protein [Function unknown]; Region: COG1511 882095007747 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882095007748 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 882095007749 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 882095007750 Predicted transcriptional regulator [Transcription]; Region: COG1959 882095007751 Transcriptional regulator; Region: Rrf2; pfam02082 882095007752 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 882095007753 L-tyrosine decarboxylase; Provisional; Region: PRK13520 882095007754 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882095007755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095007756 catalytic residue [active] 882095007757 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 882095007758 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095007759 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 882095007760 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882095007761 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882095007762 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882095007763 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 882095007764 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 882095007765 active site 882095007766 dimer interface [polypeptide binding]; other site 882095007767 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 882095007768 dimer interface [polypeptide binding]; other site 882095007769 active site 882095007770 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 882095007771 nudix motif; other site 882095007772 general stress protein 13; Validated; Region: PRK08059 882095007773 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882095007774 RNA binding site [nucleotide binding]; other site 882095007775 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 882095007776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882095007777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095007778 homodimer interface [polypeptide binding]; other site 882095007779 catalytic residue [active] 882095007780 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882095007781 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095007782 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095007783 Walker A/P-loop; other site 882095007784 ATP binding site [chemical binding]; other site 882095007785 Q-loop/lid; other site 882095007786 ABC transporter signature motif; other site 882095007787 Walker B; other site 882095007788 D-loop; other site 882095007789 H-loop/switch region; other site 882095007790 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095007791 active site 882095007792 P-loop; other site 882095007793 phosphorylation site [posttranslational modification] 882095007794 aspartate kinase; Reviewed; Region: PRK09034 882095007795 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 882095007796 putative catalytic residues [active] 882095007797 putative nucleotide binding site [chemical binding]; other site 882095007798 putative aspartate binding site [chemical binding]; other site 882095007799 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 882095007800 allosteric regulatory residue; other site 882095007801 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 882095007802 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 882095007803 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 882095007804 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882095007805 glutamine binding [chemical binding]; other site 882095007806 catalytic triad [active] 882095007807 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 882095007808 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 882095007809 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 882095007810 hypothetical protein; Provisional; Region: PRK07206 882095007811 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 882095007812 Chorismate mutase type II; Region: CM_2; smart00830 882095007813 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882095007814 Peptidase family U32; Region: Peptidase_U32; cl03113 882095007815 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 882095007816 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 882095007817 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 882095007818 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 882095007819 active site 882095007820 drug efflux system protein MdtG; Provisional; Region: PRK09874 882095007821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095007822 putative substrate translocation pore; other site 882095007823 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882095007824 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882095007825 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 882095007826 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 882095007827 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 882095007828 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 882095007829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882095007830 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 882095007831 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 882095007832 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 882095007833 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 882095007834 CoenzymeA binding site [chemical binding]; other site 882095007835 subunit interaction site [polypeptide binding]; other site 882095007836 PHB binding site; other site 882095007837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 882095007838 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 882095007839 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 882095007840 Cl- selectivity filter; other site 882095007841 Cl- binding residues [ion binding]; other site 882095007842 pore gating glutamate residue; other site 882095007843 dimer interface [polypeptide binding]; other site 882095007844 Transposase domain (DUF772); Region: DUF772; pfam05598 882095007845 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 882095007846 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 882095007847 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 882095007848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095007849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 882095007850 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882095007851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095007852 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882095007853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095007854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095007855 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 882095007856 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882095007857 NAD(P) binding site [chemical binding]; other site 882095007858 putative active site [active] 882095007859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 882095007860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 882095007861 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095007862 Leucine-rich repeats; other site 882095007863 Substrate binding site [chemical binding]; other site 882095007864 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095007865 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095007866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095007867 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007868 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007869 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007870 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007871 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007872 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095007873 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095007874 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 882095007875 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 882095007876 tetramer interfaces [polypeptide binding]; other site 882095007877 binuclear metal-binding site [ion binding]; other site 882095007878 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882095007879 Domain of unknown function DUF21; Region: DUF21; pfam01595 882095007880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882095007881 Transporter associated domain; Region: CorC_HlyC; smart01091 882095007882 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882095007883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095007884 Coenzyme A binding pocket [chemical binding]; other site 882095007885 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 882095007886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095007887 active site 882095007888 motif I; other site 882095007889 motif II; other site 882095007890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095007891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 882095007892 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882095007893 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 882095007894 active site 882095007895 metal binding site [ion binding]; metal-binding site 882095007896 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882095007897 Predicted permeases [General function prediction only]; Region: COG0730 882095007898 Predicted membrane protein [Function unknown]; Region: COG4272 882095007899 Uncharacterized conserved protein [Function unknown]; Region: COG1801 882095007900 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 882095007901 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 882095007902 FeS assembly protein SufB; Region: sufB; TIGR01980 882095007903 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 882095007904 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 882095007905 trimerization site [polypeptide binding]; other site 882095007906 active site 882095007907 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 882095007908 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 882095007909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095007910 catalytic residue [active] 882095007911 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 882095007912 FeS assembly protein SufD; Region: sufD; TIGR01981 882095007913 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 882095007914 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 882095007915 Walker A/P-loop; other site 882095007916 ATP binding site [chemical binding]; other site 882095007917 Q-loop/lid; other site 882095007918 ABC transporter signature motif; other site 882095007919 Walker B; other site 882095007920 D-loop; other site 882095007921 H-loop/switch region; other site 882095007922 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882095007923 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882095007924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095007925 ABC-ATPase subunit interface; other site 882095007926 putative PBP binding loops; other site 882095007927 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 882095007928 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882095007929 Walker A/P-loop; other site 882095007930 ATP binding site [chemical binding]; other site 882095007931 Q-loop/lid; other site 882095007932 ABC transporter signature motif; other site 882095007933 Walker B; other site 882095007934 D-loop; other site 882095007935 H-loop/switch region; other site 882095007936 NIL domain; Region: NIL; pfam09383 882095007937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095007938 dimer interface [polypeptide binding]; other site 882095007939 phosphorylation site [posttranslational modification] 882095007940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095007941 ATP binding site [chemical binding]; other site 882095007942 Mg2+ binding site [ion binding]; other site 882095007943 G-X-G motif; other site 882095007944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095007946 active site 882095007947 phosphorylation site [posttranslational modification] 882095007948 intermolecular recognition site; other site 882095007949 dimerization interface [polypeptide binding]; other site 882095007950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095007951 DNA binding site [nucleotide binding] 882095007952 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882095007953 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882095007954 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095007955 catalytic residues [active] 882095007956 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 882095007957 lipoyl attachment site [posttranslational modification]; other site 882095007958 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 882095007959 ArsC family; Region: ArsC; pfam03960 882095007960 putative ArsC-like catalytic residues; other site 882095007961 putative TRX-like catalytic residues [active] 882095007962 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882095007963 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882095007964 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882095007965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882095007966 Walker A/P-loop; other site 882095007967 ATP binding site [chemical binding]; other site 882095007968 Q-loop/lid; other site 882095007969 ABC transporter signature motif; other site 882095007970 Walker B; other site 882095007971 D-loop; other site 882095007972 H-loop/switch region; other site 882095007973 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882095007974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882095007975 ABC-ATPase subunit interface; other site 882095007976 dimer interface [polypeptide binding]; other site 882095007977 putative PBP binding regions; other site 882095007978 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882095007979 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882095007980 intersubunit interface [polypeptide binding]; other site 882095007981 Predicted esterase [General function prediction only]; Region: COG0627 882095007982 S-formylglutathione hydrolase; Region: PLN02442 882095007983 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882095007984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095007985 catalytic residue [active] 882095007986 SdpI/YhfL protein family; Region: SdpI; pfam13630 882095007987 CAT RNA binding domain; Region: CAT_RBD; smart01061 882095007988 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882095007989 PRD domain; Region: PRD; pfam00874 882095007990 PRD domain; Region: PRD; pfam00874 882095007991 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 882095007992 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 882095007993 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 882095007994 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882095007995 Predicted transcriptional regulator [Transcription]; Region: COG2378 882095007996 HTH domain; Region: HTH_11; pfam08279 882095007997 WYL domain; Region: WYL; pfam13280 882095007998 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882095007999 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882095008000 putative active site [active] 882095008001 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095008002 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882095008003 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 882095008004 active site 882095008005 catalytic site [active] 882095008006 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882095008007 putative metal binding site [ion binding]; other site 882095008008 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882095008009 putative metal binding site [ion binding]; other site 882095008010 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095008011 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882095008012 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882095008013 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882095008014 active site 882095008015 catalytic site [active] 882095008016 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882095008017 putative metal binding site [ion binding]; other site 882095008018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095008019 non-specific DNA binding site [nucleotide binding]; other site 882095008020 salt bridge; other site 882095008021 sequence-specific DNA binding site [nucleotide binding]; other site 882095008022 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882095008023 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 882095008024 SmpB-tmRNA interface; other site 882095008025 ribonuclease R; Region: RNase_R; TIGR02063 882095008026 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 882095008027 RNB domain; Region: RNB; pfam00773 882095008028 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 882095008029 RNA binding site [nucleotide binding]; other site 882095008030 Esterase/lipase [General function prediction only]; Region: COG1647 882095008031 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095008032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882095008033 Preprotein translocase SecG subunit; Region: SecG; cl09123 882095008034 Esterase/lipase [General function prediction only]; Region: COG1647 882095008035 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882095008036 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 882095008037 PGAP1-like protein; Region: PGAP1; pfam07819 882095008038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882095008039 enolase; Provisional; Region: eno; PRK00077 882095008040 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 882095008041 dimer interface [polypeptide binding]; other site 882095008042 metal binding site [ion binding]; metal-binding site 882095008043 substrate binding pocket [chemical binding]; other site 882095008044 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 882095008045 phosphoglyceromutase; Provisional; Region: PRK05434 882095008046 triosephosphate isomerase; Provisional; Region: PRK14567 882095008047 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882095008048 substrate binding site [chemical binding]; other site 882095008049 dimer interface [polypeptide binding]; other site 882095008050 catalytic triad [active] 882095008051 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 882095008052 Phosphoglycerate kinase; Region: PGK; pfam00162 882095008053 substrate binding site [chemical binding]; other site 882095008054 hinge regions; other site 882095008055 ADP binding site [chemical binding]; other site 882095008056 catalytic site [active] 882095008057 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 882095008058 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 882095008059 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 882095008060 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882095008061 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882095008062 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 882095008063 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 882095008064 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 882095008065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095008066 DNA binding site [nucleotide binding] 882095008067 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 882095008068 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 882095008069 active site 882095008070 dimer interface [polypeptide binding]; other site 882095008071 MMPL family; Region: MMPL; pfam03176 882095008072 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 882095008073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095008074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095008075 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 882095008076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 882095008077 Chitin binding domain; Region: Chitin_bind_3; pfam03067 882095008078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882095008079 Interdomain contacts; other site 882095008080 Cytokine receptor motif; other site 882095008081 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882095008082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882095008083 Interdomain contacts; other site 882095008084 Cytokine receptor motif; other site 882095008085 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882095008086 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882095008087 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882095008088 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882095008089 Clp protease; Region: CLP_protease; pfam00574 882095008090 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882095008091 oligomer interface [polypeptide binding]; other site 882095008092 active site residues [active] 882095008093 amino acid transporter; Region: 2A0306; TIGR00909 882095008094 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882095008095 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882095008096 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095008097 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095008098 Substrate binding site [chemical binding]; other site 882095008099 Leucine rich repeat; Region: LRR_8; pfam13855 882095008100 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095008101 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882095008102 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 882095008103 active site 882095008104 FMN binding site [chemical binding]; other site 882095008105 substrate binding site [chemical binding]; other site 882095008106 homotetramer interface [polypeptide binding]; other site 882095008107 catalytic residue [active] 882095008108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 882095008109 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 882095008110 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 882095008111 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 882095008112 phosphate binding site [ion binding]; other site 882095008113 putative substrate binding pocket [chemical binding]; other site 882095008114 dimer interface [polypeptide binding]; other site 882095008115 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 882095008116 AAA domain; Region: AAA_18; pfam13238 882095008117 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 882095008118 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882095008119 active site 882095008120 substrate binding site [chemical binding]; other site 882095008121 metal binding site [ion binding]; metal-binding site 882095008122 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 882095008123 active site 882095008124 catalytic residues [active] 882095008125 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 882095008126 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 882095008127 NAD binding site [chemical binding]; other site 882095008128 homodimer interface [polypeptide binding]; other site 882095008129 active site 882095008130 substrate binding site [chemical binding]; other site 882095008131 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 882095008132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882095008133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095008134 TPR repeat; Region: TPR_11; pfam13414 882095008135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095008136 binding surface 882095008137 TPR motif; other site 882095008138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 882095008139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882095008140 binding surface 882095008141 TPR motif; other site 882095008142 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882095008143 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882095008144 putative trimer interface [polypeptide binding]; other site 882095008145 putative CoA binding site [chemical binding]; other site 882095008146 pyrophosphatase PpaX; Provisional; Region: PRK13288 882095008147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095008148 motif II; other site 882095008149 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 882095008150 HPr kinase/phosphorylase; Provisional; Region: PRK05428 882095008151 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 882095008152 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 882095008153 Hpr binding site; other site 882095008154 active site 882095008155 homohexamer subunit interaction site [polypeptide binding]; other site 882095008156 Predicted membrane protein [Function unknown]; Region: COG1950 882095008157 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 882095008158 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 882095008159 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882095008160 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882095008161 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882095008162 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882095008163 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 882095008164 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882095008165 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882095008166 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 882095008167 excinuclease ABC subunit B; Provisional; Region: PRK05298 882095008168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095008169 ATP binding site [chemical binding]; other site 882095008170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095008171 nucleotide binding region [chemical binding]; other site 882095008172 ATP-binding site [chemical binding]; other site 882095008173 Ultra-violet resistance protein B; Region: UvrB; pfam12344 882095008174 UvrB/uvrC motif; Region: UVR; pfam02151 882095008175 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 882095008176 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 882095008177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882095008178 dimerization interface [polypeptide binding]; other site 882095008179 putative DNA binding site [nucleotide binding]; other site 882095008180 putative Zn2+ binding site [ion binding]; other site 882095008181 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 882095008182 PhoU domain; Region: PhoU; pfam01895 882095008183 PhoU domain; Region: PhoU; pfam01895 882095008184 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882095008185 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882095008186 Walker A/P-loop; other site 882095008187 ATP binding site [chemical binding]; other site 882095008188 Q-loop/lid; other site 882095008189 ABC transporter signature motif; other site 882095008190 Walker B; other site 882095008191 D-loop; other site 882095008192 H-loop/switch region; other site 882095008193 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882095008194 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882095008195 Walker A/P-loop; other site 882095008196 ATP binding site [chemical binding]; other site 882095008197 Q-loop/lid; other site 882095008198 ABC transporter signature motif; other site 882095008199 Walker B; other site 882095008200 D-loop; other site 882095008201 H-loop/switch region; other site 882095008202 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 882095008203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095008204 dimer interface [polypeptide binding]; other site 882095008205 conserved gate region; other site 882095008206 putative PBP binding loops; other site 882095008207 ABC-ATPase subunit interface; other site 882095008208 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 882095008209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095008210 dimer interface [polypeptide binding]; other site 882095008211 conserved gate region; other site 882095008212 putative PBP binding loops; other site 882095008213 ABC-ATPase subunit interface; other site 882095008214 PBP superfamily domain; Region: PBP_like_2; cl17296 882095008215 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 882095008216 HAMP domain; Region: HAMP; pfam00672 882095008217 dimerization interface [polypeptide binding]; other site 882095008218 PAS domain; Region: PAS; smart00091 882095008219 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 882095008220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095008221 dimer interface [polypeptide binding]; other site 882095008222 phosphorylation site [posttranslational modification] 882095008223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095008224 ATP binding site [chemical binding]; other site 882095008225 Mg2+ binding site [ion binding]; other site 882095008226 G-X-G motif; other site 882095008227 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095008228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095008229 active site 882095008230 phosphorylation site [posttranslational modification] 882095008231 intermolecular recognition site; other site 882095008232 dimerization interface [polypeptide binding]; other site 882095008233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095008234 DNA binding site [nucleotide binding] 882095008235 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882095008236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882095008237 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882095008238 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 882095008239 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882095008240 putative active site [active] 882095008241 catalytic site [active] 882095008242 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882095008243 putative active site [active] 882095008244 catalytic site [active] 882095008245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882095008246 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 882095008247 Peptidase family M23; Region: Peptidase_M23; pfam01551 882095008248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882095008249 NlpC/P60 family; Region: NLPC_P60; pfam00877 882095008250 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 882095008251 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 882095008252 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 882095008253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095008254 Walker A/P-loop; other site 882095008255 ATP binding site [chemical binding]; other site 882095008256 Q-loop/lid; other site 882095008257 ABC transporter signature motif; other site 882095008258 Walker B; other site 882095008259 D-loop; other site 882095008260 H-loop/switch region; other site 882095008261 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882095008262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095008263 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882095008264 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882095008265 peptide chain release factor 2; Validated; Region: prfB; PRK00578 882095008266 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882095008267 RF-1 domain; Region: RF-1; pfam00472 882095008268 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 882095008269 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882095008270 nucleotide binding region [chemical binding]; other site 882095008271 helicase superfamily c-terminal domain; Region: HELICc; smart00490 882095008272 ATP-binding site [chemical binding]; other site 882095008273 SEC-C motif; Region: SEC-C; pfam02810 882095008274 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 882095008275 30S subunit binding site; other site 882095008276 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 882095008277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095008278 active site 882095008279 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 882095008280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095008281 ATP binding site [chemical binding]; other site 882095008282 putative Mg++ binding site [ion binding]; other site 882095008283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095008284 nucleotide binding region [chemical binding]; other site 882095008285 ATP-binding site [chemical binding]; other site 882095008286 EDD domain protein, DegV family; Region: DegV; TIGR00762 882095008287 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882095008288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882095008289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095008290 active site 882095008291 phosphorylation site [posttranslational modification] 882095008292 intermolecular recognition site; other site 882095008293 dimerization interface [polypeptide binding]; other site 882095008294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882095008295 DNA binding residues [nucleotide binding] 882095008296 dimerization interface [polypeptide binding]; other site 882095008297 Uncharacterized conserved protein [Function unknown]; Region: COG1739 882095008298 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 882095008299 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 882095008300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882095008301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882095008302 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882095008303 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882095008304 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882095008305 Mg++ binding site [ion binding]; other site 882095008306 putative catalytic motif [active] 882095008307 substrate binding site [chemical binding]; other site 882095008308 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 882095008309 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 882095008310 active site 882095008311 octamer interface [polypeptide binding]; other site 882095008312 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 882095008313 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 882095008314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008315 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882095008317 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882095008318 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882095008319 dimer interface [polypeptide binding]; other site 882095008320 ssDNA binding site [nucleotide binding]; other site 882095008321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882095008322 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 882095008323 rod shape-determining protein Mbl; Provisional; Region: PRK13928 882095008324 MreB and similar proteins; Region: MreB_like; cd10225 882095008325 nucleotide binding site [chemical binding]; other site 882095008326 Mg binding site [ion binding]; other site 882095008327 putative protofilament interaction site [polypeptide binding]; other site 882095008328 RodZ interaction site [polypeptide binding]; other site 882095008329 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882095008330 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882095008331 hinge; other site 882095008332 active site 882095008333 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 882095008334 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 882095008335 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 882095008336 gamma subunit interface [polypeptide binding]; other site 882095008337 epsilon subunit interface [polypeptide binding]; other site 882095008338 LBP interface [polypeptide binding]; other site 882095008339 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 882095008340 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882095008341 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882095008342 alpha subunit interaction interface [polypeptide binding]; other site 882095008343 Walker A motif; other site 882095008344 ATP binding site [chemical binding]; other site 882095008345 Walker B motif; other site 882095008346 inhibitor binding site; inhibition site 882095008347 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882095008348 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882095008349 core domain interface [polypeptide binding]; other site 882095008350 delta subunit interface [polypeptide binding]; other site 882095008351 epsilon subunit interface [polypeptide binding]; other site 882095008352 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 882095008353 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882095008354 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 882095008355 beta subunit interaction interface [polypeptide binding]; other site 882095008356 Walker A motif; other site 882095008357 ATP binding site [chemical binding]; other site 882095008358 Walker B motif; other site 882095008359 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882095008360 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 882095008361 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882095008362 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 882095008363 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 882095008364 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 882095008365 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 882095008366 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 882095008367 ATP synthase I chain; Region: ATP_synt_I; pfam03899 882095008368 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 882095008369 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 882095008370 active site 882095008371 homodimer interface [polypeptide binding]; other site 882095008372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882095008373 active site 882095008374 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 882095008375 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 882095008376 dimer interface [polypeptide binding]; other site 882095008377 active site 882095008378 glycine-pyridoxal phosphate binding site [chemical binding]; other site 882095008379 folate binding site [chemical binding]; other site 882095008380 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882095008381 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882095008382 active site 882095008383 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 882095008384 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 882095008385 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 882095008386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095008387 S-adenosylmethionine binding site [chemical binding]; other site 882095008388 peptide chain release factor 1; Validated; Region: prfA; PRK00591 882095008389 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882095008390 RF-1 domain; Region: RF-1; pfam00472 882095008391 thymidine kinase; Provisional; Region: PRK04296 882095008392 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882095008393 ATP binding site [chemical binding]; other site 882095008394 Walker A motif; other site 882095008395 Walker B motif; other site 882095008396 homoserine kinase; Provisional; Region: PRK01212 882095008397 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882095008398 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882095008399 threonine synthase; Reviewed; Region: PRK06721 882095008400 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 882095008401 homodimer interface [polypeptide binding]; other site 882095008402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095008403 catalytic residue [active] 882095008404 homoserine dehydrogenase; Provisional; Region: PRK06349 882095008405 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 882095008406 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 882095008407 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 882095008408 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 882095008409 Predicted membrane protein [Function unknown]; Region: COG2246 882095008410 GtrA-like protein; Region: GtrA; pfam04138 882095008411 transcription termination factor Rho; Provisional; Region: rho; PRK09376 882095008412 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 882095008413 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882095008414 RNA binding site [nucleotide binding]; other site 882095008415 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 882095008416 multimer interface [polypeptide binding]; other site 882095008417 Walker A motif; other site 882095008418 ATP binding site [chemical binding]; other site 882095008419 Walker B motif; other site 882095008420 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882095008421 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882095008422 hinge; other site 882095008423 active site 882095008424 Predicted integral membrane protein [Function unknown]; Region: COG0392 882095008425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882095008426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 882095008427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882095008428 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 882095008429 putative ADP-binding pocket [chemical binding]; other site 882095008430 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 882095008431 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882095008432 intersubunit interface [polypeptide binding]; other site 882095008433 active site 882095008434 zinc binding site [ion binding]; other site 882095008435 Na+ binding site [ion binding]; other site 882095008436 putative lipid kinase; Reviewed; Region: PRK13055 882095008437 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882095008438 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 882095008439 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 882095008440 substrate binding site [chemical binding]; other site 882095008441 SH3-like domain; Region: SH3_8; pfam13457 882095008442 SH3-like domain; Region: SH3_8; pfam13457 882095008443 SH3-like domain; Region: SH3_8; pfam13457 882095008444 CTP synthetase; Validated; Region: pyrG; PRK05380 882095008445 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 882095008446 Catalytic site [active] 882095008447 active site 882095008448 UTP binding site [chemical binding]; other site 882095008449 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 882095008450 active site 882095008451 putative oxyanion hole; other site 882095008452 catalytic triad [active] 882095008453 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 882095008454 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 882095008455 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 882095008456 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 882095008457 active site 882095008458 HIGH motif; other site 882095008459 KMSK motif region; other site 882095008460 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 882095008461 tRNA binding surface [nucleotide binding]; other site 882095008462 anticodon binding site; other site 882095008463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 882095008464 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 882095008465 Peptidase family M50; Region: Peptidase_M50; pfam02163 882095008466 active site 882095008467 putative substrate binding region [chemical binding]; other site 882095008468 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 882095008469 active site 1 [active] 882095008470 dimer interface [polypeptide binding]; other site 882095008471 hexamer interface [polypeptide binding]; other site 882095008472 active site 2 [active] 882095008473 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 882095008474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095008475 Zn2+ binding site [ion binding]; other site 882095008476 Mg2+ binding site [ion binding]; other site 882095008477 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882095008478 conserved hypothetical protein TIGR01655; Region: yxeA_fam 882095008479 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882095008480 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882095008481 peptide binding site [polypeptide binding]; other site 882095008482 Predicted integral membrane protein [Function unknown]; Region: COG5658 882095008483 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882095008484 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 882095008485 catalytic triad [active] 882095008486 metal binding site [ion binding]; metal-binding site 882095008487 conserved cis-peptide bond; other site 882095008488 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 882095008489 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882095008490 folate binding site [chemical binding]; other site 882095008491 NADP+ binding site [chemical binding]; other site 882095008492 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 882095008493 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 882095008494 putative NAD(P) binding site [chemical binding]; other site 882095008495 dimer interface [polypeptide binding]; other site 882095008496 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 882095008497 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882095008498 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095008499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095008500 active site 882095008501 motif I; other site 882095008502 motif II; other site 882095008503 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 882095008504 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882095008505 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882095008506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095008507 Walker A/P-loop; other site 882095008508 ATP binding site [chemical binding]; other site 882095008509 Q-loop/lid; other site 882095008510 ABC transporter signature motif; other site 882095008511 Walker B; other site 882095008512 D-loop; other site 882095008513 H-loop/switch region; other site 882095008514 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882095008515 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882095008516 FtsX-like permease family; Region: FtsX; pfam02687 882095008517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882095008518 dimerization interface [polypeptide binding]; other site 882095008519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095008520 dimer interface [polypeptide binding]; other site 882095008521 phosphorylation site [posttranslational modification] 882095008522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095008523 ATP binding site [chemical binding]; other site 882095008524 Mg2+ binding site [ion binding]; other site 882095008525 G-X-G motif; other site 882095008526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095008527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095008528 active site 882095008529 phosphorylation site [posttranslational modification] 882095008530 intermolecular recognition site; other site 882095008531 dimerization interface [polypeptide binding]; other site 882095008532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095008533 DNA binding site [nucleotide binding] 882095008534 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 882095008535 Uncharacterized conserved protein [Function unknown]; Region: COG2427 882095008536 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 882095008537 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 882095008538 catalytic loop [active] 882095008539 iron binding site [ion binding]; other site 882095008540 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 882095008541 4Fe-4S binding domain; Region: Fer4; pfam00037 882095008542 4Fe-4S binding domain; Region: Fer4; pfam00037 882095008543 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 882095008544 [4Fe-4S] binding site [ion binding]; other site 882095008545 molybdopterin cofactor binding site; other site 882095008546 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 882095008547 molybdopterin cofactor binding site; other site 882095008548 Uncharacterized conserved protein [Function unknown]; Region: COG1912 882095008549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095008550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095008551 putative substrate translocation pore; other site 882095008552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095008553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095008554 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 882095008555 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 882095008556 Walker A motif; other site 882095008557 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095008558 SH3-like domain; Region: SH3_8; pfam13457 882095008559 SH3-like domain; Region: SH3_8; pfam13457 882095008560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095008561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095008562 active site 882095008563 catalytic tetrad [active] 882095008564 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095008565 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095008566 DNA binding residues [nucleotide binding] 882095008567 putative dimer interface [polypeptide binding]; other site 882095008568 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 882095008569 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 882095008570 23S rRNA interface [nucleotide binding]; other site 882095008571 L3 interface [polypeptide binding]; other site 882095008572 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 882095008573 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 882095008574 dimerization interface 3.5A [polypeptide binding]; other site 882095008575 active site 882095008576 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882095008577 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 882095008578 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882095008579 Walker A/P-loop; other site 882095008580 ATP binding site [chemical binding]; other site 882095008581 Q-loop/lid; other site 882095008582 ABC transporter signature motif; other site 882095008583 Walker B; other site 882095008584 D-loop; other site 882095008585 H-loop/switch region; other site 882095008586 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 882095008587 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882095008588 Walker A/P-loop; other site 882095008589 ATP binding site [chemical binding]; other site 882095008590 Q-loop/lid; other site 882095008591 ABC transporter signature motif; other site 882095008592 Walker B; other site 882095008593 D-loop; other site 882095008594 H-loop/switch region; other site 882095008595 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 882095008596 MgtC family; Region: MgtC; pfam02308 882095008597 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 882095008598 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882095008599 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 882095008600 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 882095008601 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 882095008602 alphaNTD - beta interaction site [polypeptide binding]; other site 882095008603 alphaNTD homodimer interface [polypeptide binding]; other site 882095008604 alphaNTD - beta' interaction site [polypeptide binding]; other site 882095008605 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 882095008606 30S ribosomal protein S11; Validated; Region: PRK05309 882095008607 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 882095008608 30S ribosomal protein S13; Region: bact_S13; TIGR03631 882095008609 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 882095008610 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 882095008611 rRNA binding site [nucleotide binding]; other site 882095008612 predicted 30S ribosome binding site; other site 882095008613 adenylate kinase; Reviewed; Region: adk; PRK00279 882095008614 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 882095008615 AMP-binding site [chemical binding]; other site 882095008616 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 882095008617 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 882095008618 SecY translocase; Region: SecY; pfam00344 882095008619 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 882095008620 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 882095008621 23S rRNA binding site [nucleotide binding]; other site 882095008622 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 882095008623 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 882095008624 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 882095008625 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 882095008626 5S rRNA interface [nucleotide binding]; other site 882095008627 L27 interface [polypeptide binding]; other site 882095008628 23S rRNA interface [nucleotide binding]; other site 882095008629 L5 interface [polypeptide binding]; other site 882095008630 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 882095008631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882095008632 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882095008633 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 882095008634 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 882095008635 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 882095008636 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 882095008637 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 882095008638 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 882095008639 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 882095008640 RNA binding site [nucleotide binding]; other site 882095008641 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 882095008642 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 882095008643 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 882095008644 23S rRNA interface [nucleotide binding]; other site 882095008645 putative translocon interaction site; other site 882095008646 signal recognition particle (SRP54) interaction site; other site 882095008647 L23 interface [polypeptide binding]; other site 882095008648 trigger factor interaction site; other site 882095008649 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 882095008650 23S rRNA interface [nucleotide binding]; other site 882095008651 5S rRNA interface [nucleotide binding]; other site 882095008652 putative antibiotic binding site [chemical binding]; other site 882095008653 L25 interface [polypeptide binding]; other site 882095008654 L27 interface [polypeptide binding]; other site 882095008655 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 882095008656 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 882095008657 G-X-X-G motif; other site 882095008658 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 882095008659 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 882095008660 putative translocon binding site; other site 882095008661 protein-rRNA interface [nucleotide binding]; other site 882095008662 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 882095008663 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 882095008664 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 882095008665 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 882095008666 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 882095008667 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 882095008668 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 882095008669 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 882095008670 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882095008671 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 882095008672 UbiA prenyltransferase family; Region: UbiA; pfam01040 882095008673 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 882095008674 ApbE family; Region: ApbE; pfam02424 882095008675 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 882095008676 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882095008677 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882095008678 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882095008679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882095008680 Predicted membrane protein [Function unknown]; Region: COG2259 882095008681 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882095008682 trimer interface [polypeptide binding]; other site 882095008683 Predicted membrane protein [Function unknown]; Region: COG4769 882095008684 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882095008685 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882095008686 substrate binding pocket [chemical binding]; other site 882095008687 chain length determination region; other site 882095008688 substrate-Mg2+ binding site; other site 882095008689 catalytic residues [active] 882095008690 aspartate-rich region 1; other site 882095008691 active site lid residues [active] 882095008692 aspartate-rich region 2; other site 882095008693 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 882095008694 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 882095008695 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 882095008696 active site 882095008697 metal binding site [ion binding]; metal-binding site 882095008698 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 882095008699 hypothetical protein; Provisional; Region: PRK02947 882095008700 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095008701 putative active site [active] 882095008702 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 882095008703 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 882095008704 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 882095008705 active site 882095008706 substrate binding pocket [chemical binding]; other site 882095008707 homodimer interaction site [polypeptide binding]; other site 882095008708 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 882095008709 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 882095008710 active site 882095008711 P-loop; other site 882095008712 phosphorylation site [posttranslational modification] 882095008713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095008714 active site 882095008715 phosphorylation site [posttranslational modification] 882095008716 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095008717 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095008718 PRD domain; Region: PRD; pfam00874 882095008719 PRD domain; Region: PRD; pfam00874 882095008720 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095008721 active site 882095008722 P-loop; other site 882095008723 phosphorylation site [posttranslational modification] 882095008724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095008725 active site 882095008726 phosphorylation site [posttranslational modification] 882095008727 elongation factor Tu; Reviewed; Region: PRK00049 882095008728 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 882095008729 G1 box; other site 882095008730 GEF interaction site [polypeptide binding]; other site 882095008731 GTP/Mg2+ binding site [chemical binding]; other site 882095008732 Switch I region; other site 882095008733 G2 box; other site 882095008734 G3 box; other site 882095008735 Switch II region; other site 882095008736 G4 box; other site 882095008737 G5 box; other site 882095008738 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 882095008739 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 882095008740 Antibiotic Binding Site [chemical binding]; other site 882095008741 elongation factor G; Reviewed; Region: PRK00007 882095008742 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 882095008743 G1 box; other site 882095008744 putative GEF interaction site [polypeptide binding]; other site 882095008745 GTP/Mg2+ binding site [chemical binding]; other site 882095008746 Switch I region; other site 882095008747 G2 box; other site 882095008748 G3 box; other site 882095008749 Switch II region; other site 882095008750 G4 box; other site 882095008751 G5 box; other site 882095008752 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 882095008753 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 882095008754 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 882095008755 30S ribosomal protein S7; Validated; Region: PRK05302 882095008756 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 882095008757 S17 interaction site [polypeptide binding]; other site 882095008758 S8 interaction site; other site 882095008759 16S rRNA interaction site [nucleotide binding]; other site 882095008760 streptomycin interaction site [chemical binding]; other site 882095008761 23S rRNA interaction site [nucleotide binding]; other site 882095008762 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 882095008763 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 882095008764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882095008765 Zn2+ binding site [ion binding]; other site 882095008766 Mg2+ binding site [ion binding]; other site 882095008767 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 882095008768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095008769 Coenzyme A binding pocket [chemical binding]; other site 882095008770 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 882095008771 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095008772 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095008773 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882095008774 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882095008775 substrate binding site [chemical binding]; other site 882095008776 hexamer interface [polypeptide binding]; other site 882095008777 metal binding site [ion binding]; metal-binding site 882095008778 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882095008779 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882095008780 TPP-binding site [chemical binding]; other site 882095008781 dimer interface [polypeptide binding]; other site 882095008782 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882095008783 PYR/PP interface [polypeptide binding]; other site 882095008784 dimer interface [polypeptide binding]; other site 882095008785 TPP binding site [chemical binding]; other site 882095008786 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882095008787 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882095008788 substrate binding site [chemical binding]; other site 882095008789 hexamer interface [polypeptide binding]; other site 882095008790 metal binding site [ion binding]; metal-binding site 882095008791 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882095008792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882095008793 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 882095008794 putative NAD(P) binding site [chemical binding]; other site 882095008795 catalytic Zn binding site [ion binding]; other site 882095008796 structural Zn binding site [ion binding]; other site 882095008797 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882095008798 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882095008799 putative NAD(P) binding site [chemical binding]; other site 882095008800 catalytic Zn binding site [ion binding]; other site 882095008801 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882095008802 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882095008803 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882095008804 active site 882095008805 P-loop; other site 882095008806 phosphorylation site [posttranslational modification] 882095008807 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095008808 active site 882095008809 phosphorylation site [posttranslational modification] 882095008810 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095008811 PRD domain; Region: PRD; pfam00874 882095008812 PRD domain; Region: PRD; pfam00874 882095008813 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095008814 active site 882095008815 P-loop; other site 882095008816 phosphorylation site [posttranslational modification] 882095008817 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 882095008818 active site 882095008819 phosphorylation site [posttranslational modification] 882095008820 Predicted membrane protein [Function unknown]; Region: COG4905 882095008821 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 882095008822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882095008823 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882095008824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882095008825 active site 882095008826 Helix-turn-helix domain; Region: HTH_18; pfam12833 882095008827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882095008828 Ligand Binding Site [chemical binding]; other site 882095008829 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 882095008830 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 882095008831 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 882095008832 active site 882095008833 DNA binding site [nucleotide binding] 882095008834 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882095008835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882095008836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882095008837 active site 882095008838 phosphorylation site [posttranslational modification] 882095008839 intermolecular recognition site; other site 882095008840 dimerization interface [polypeptide binding]; other site 882095008841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882095008842 DNA binding site [nucleotide binding] 882095008843 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 882095008844 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 882095008845 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 882095008846 Ligand Binding Site [chemical binding]; other site 882095008847 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 882095008848 GAF domain; Region: GAF_3; pfam13492 882095008849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882095008850 dimer interface [polypeptide binding]; other site 882095008851 phosphorylation site [posttranslational modification] 882095008852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882095008853 ATP binding site [chemical binding]; other site 882095008854 Mg2+ binding site [ion binding]; other site 882095008855 G-X-G motif; other site 882095008856 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 882095008857 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 882095008858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095008859 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 882095008860 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095008861 active site 882095008862 P-loop; other site 882095008863 phosphorylation site [posttranslational modification] 882095008864 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095008865 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882095008866 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095008867 methionine cluster; other site 882095008868 active site 882095008869 phosphorylation site [posttranslational modification] 882095008870 metal binding site [ion binding]; metal-binding site 882095008871 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882095008872 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882095008873 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 882095008874 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882095008875 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882095008876 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882095008877 Soluble P-type ATPase [General function prediction only]; Region: COG4087 882095008878 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882095008879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095008880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095008881 autolysin; Reviewed; Region: PRK06347 882095008882 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882095008883 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008884 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008885 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008886 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882095008887 Protein of unknown function (DUF970); Region: DUF970; pfam06153 882095008888 thymidylate kinase; Validated; Region: tmk; PRK00698 882095008889 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 882095008890 TMP-binding site; other site 882095008891 ATP-binding site [chemical binding]; other site 882095008892 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 882095008893 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882095008894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095008895 catalytic residue [active] 882095008896 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 882095008897 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 882095008898 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882095008899 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882095008900 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 882095008901 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 882095008902 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095008903 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095008904 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095008905 putative active site [active] 882095008906 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882095008907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095008908 active site 882095008909 motif I; other site 882095008910 motif II; other site 882095008911 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882095008912 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 882095008913 nudix motif; other site 882095008914 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882095008915 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882095008916 active site 882095008917 catalytic tetrad [active] 882095008918 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 882095008919 recombination protein RecR; Reviewed; Region: recR; PRK00076 882095008920 RecR protein; Region: RecR; pfam02132 882095008921 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 882095008922 putative active site [active] 882095008923 putative metal-binding site [ion binding]; other site 882095008924 tetramer interface [polypeptide binding]; other site 882095008925 hypothetical protein; Validated; Region: PRK00153 882095008926 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 882095008927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882095008928 Walker A motif; other site 882095008929 ATP binding site [chemical binding]; other site 882095008930 Walker B motif; other site 882095008931 arginine finger; other site 882095008932 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 882095008933 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 882095008934 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 882095008935 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095008936 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095008937 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 882095008938 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 882095008939 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 882095008940 N- and C-terminal domain interface [polypeptide binding]; other site 882095008941 active site 882095008942 catalytic site [active] 882095008943 metal binding site [ion binding]; metal-binding site 882095008944 carbohydrate binding site [chemical binding]; other site 882095008945 ATP binding site [chemical binding]; other site 882095008946 SH3-like domain; Region: SH3_8; pfam13457 882095008947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 882095008948 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 882095008949 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095008950 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 882095008951 Walker A/P-loop; other site 882095008952 ATP binding site [chemical binding]; other site 882095008953 Q-loop/lid; other site 882095008954 ABC transporter signature motif; other site 882095008955 Walker B; other site 882095008956 D-loop; other site 882095008957 H-loop/switch region; other site 882095008958 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882095008959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095008960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095008961 Walker A/P-loop; other site 882095008962 ATP binding site [chemical binding]; other site 882095008963 Q-loop/lid; other site 882095008964 ABC transporter signature motif; other site 882095008965 Walker B; other site 882095008966 D-loop; other site 882095008967 H-loop/switch region; other site 882095008968 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 882095008969 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 882095008970 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 882095008971 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 882095008972 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 882095008973 nucleoside/Zn binding site; other site 882095008974 dimer interface [polypeptide binding]; other site 882095008975 catalytic motif [active] 882095008976 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882095008977 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 882095008978 active site 882095008979 acyl-activating enzyme (AAE) consensus motif; other site 882095008980 putative CoA binding site [chemical binding]; other site 882095008981 AMP binding site [chemical binding]; other site 882095008982 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882095008983 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882095008984 active site 882095008985 trimer interface [polypeptide binding]; other site 882095008986 allosteric site; other site 882095008987 active site lid [active] 882095008988 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882095008989 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 882095008990 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882095008991 DNA binding residues [nucleotide binding] 882095008992 drug binding residues [chemical binding]; other site 882095008993 dimer interface [polypeptide binding]; other site 882095008994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882095008995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 882095008996 Coenzyme A binding pocket [chemical binding]; other site 882095008997 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882095008998 dimer interface [polypeptide binding]; other site 882095008999 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882095009000 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882095009001 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882095009002 MarR family; Region: MarR; pfam01047 882095009003 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882095009004 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882095009005 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882095009006 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882095009007 DNA binding residues [nucleotide binding] 882095009008 putative dimer interface [polypeptide binding]; other site 882095009009 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 882095009010 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 882095009011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095009012 active site 882095009013 motif I; other site 882095009014 motif II; other site 882095009015 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095009016 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095009017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095009018 putative active site [active] 882095009019 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882095009020 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095009021 active site 882095009022 phosphorylation site [posttranslational modification] 882095009023 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882095009024 active site 882095009025 P-loop; other site 882095009026 phosphorylation site [posttranslational modification] 882095009027 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882095009028 alpha-mannosidase; Provisional; Region: PRK09819 882095009029 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882095009030 active site 882095009031 metal binding site [ion binding]; metal-binding site 882095009032 catalytic site [active] 882095009033 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882095009034 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882095009035 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882095009036 active site 882095009037 homodimer interface [polypeptide binding]; other site 882095009038 catalytic site [active] 882095009039 glycerate kinase; Region: TIGR00045 882095009040 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095009041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095009042 DNA binding site [nucleotide binding] 882095009043 domain linker motif; other site 882095009044 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882095009045 putative dimerization interface [polypeptide binding]; other site 882095009046 putative ligand binding site [chemical binding]; other site 882095009047 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882095009048 Domain of unknown function DUF21; Region: DUF21; pfam01595 882095009049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882095009050 Transporter associated domain; Region: CorC_HlyC; pfam03471 882095009051 NAD-dependent deacetylase; Provisional; Region: PRK00481 882095009052 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 882095009053 NAD+ binding site [chemical binding]; other site 882095009054 substrate binding site [chemical binding]; other site 882095009055 putative Zn binding site [ion binding]; other site 882095009056 Pathogenicity locus; Region: Cdd1; pfam11731 882095009057 drug efflux system protein MdtG; Provisional; Region: PRK09874 882095009058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009059 putative substrate translocation pore; other site 882095009060 Src Homology 3 domain superfamily; Region: SH3; cl17036 882095009061 Variant SH3 domain; Region: SH3_2; pfam07653 882095009062 peptide ligand binding site [polypeptide binding]; other site 882095009063 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882095009064 active site 882095009065 intersubunit interactions; other site 882095009066 catalytic residue [active] 882095009067 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882095009068 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882095009069 ligand binding site [chemical binding]; other site 882095009070 flexible hinge region; other site 882095009071 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882095009072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095009073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095009074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095009075 Walker A/P-loop; other site 882095009076 ATP binding site [chemical binding]; other site 882095009077 Q-loop/lid; other site 882095009078 ABC transporter signature motif; other site 882095009079 Walker B; other site 882095009080 D-loop; other site 882095009081 H-loop/switch region; other site 882095009082 TfoX C-terminal domain; Region: TfoX_C; pfam04994 882095009083 seryl-tRNA synthetase; Provisional; Region: PRK05431 882095009084 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 882095009085 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 882095009086 dimer interface [polypeptide binding]; other site 882095009087 active site 882095009088 motif 1; other site 882095009089 motif 2; other site 882095009090 motif 3; other site 882095009091 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 882095009092 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 882095009093 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 882095009094 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882095009095 glutamine binding [chemical binding]; other site 882095009096 catalytic triad [active] 882095009097 aminodeoxychorismate synthase; Provisional; Region: PRK07508 882095009098 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882095009099 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 882095009100 substrate-cofactor binding pocket; other site 882095009101 homodimer interface [polypeptide binding]; other site 882095009102 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882095009103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882095009104 catalytic residue [active] 882095009105 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095009106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095009107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095009108 Walker A/P-loop; other site 882095009109 ATP binding site [chemical binding]; other site 882095009110 Q-loop/lid; other site 882095009111 ABC transporter signature motif; other site 882095009112 Walker B; other site 882095009113 D-loop; other site 882095009114 H-loop/switch region; other site 882095009115 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882095009116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882095009117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882095009118 Walker A/P-loop; other site 882095009119 ATP binding site [chemical binding]; other site 882095009120 Q-loop/lid; other site 882095009121 ABC transporter signature motif; other site 882095009122 Walker B; other site 882095009123 D-loop; other site 882095009124 H-loop/switch region; other site 882095009125 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 882095009126 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 882095009127 Ligand binding site; other site 882095009128 Putative Catalytic site; other site 882095009129 DXD motif; other site 882095009130 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 882095009131 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882095009132 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 882095009133 Predicted acyl esterases [General function prediction only]; Region: COG2936 882095009134 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 882095009135 DNA topoisomerase III; Provisional; Region: PRK07726 882095009136 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 882095009137 active site 882095009138 putative interdomain interaction site [polypeptide binding]; other site 882095009139 putative metal-binding site [ion binding]; other site 882095009140 putative nucleotide binding site [chemical binding]; other site 882095009141 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882095009142 domain I; other site 882095009143 DNA binding groove [nucleotide binding] 882095009144 phosphate binding site [ion binding]; other site 882095009145 domain II; other site 882095009146 domain III; other site 882095009147 nucleotide binding site [chemical binding]; other site 882095009148 catalytic site [active] 882095009149 domain IV; other site 882095009150 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 882095009151 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 882095009152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882095009153 ATP binding site [chemical binding]; other site 882095009154 putative Mg++ binding site [ion binding]; other site 882095009155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882095009156 nucleotide binding region [chemical binding]; other site 882095009157 ATP-binding site [chemical binding]; other site 882095009158 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 882095009159 HRDC domain; Region: HRDC; pfam00570 882095009160 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 882095009161 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 882095009162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 882095009163 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882095009164 active site 882095009165 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 882095009166 putative ADP-ribose binding site [chemical binding]; other site 882095009167 putative active site [active] 882095009168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882095009169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095009170 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095009171 ABC transporter; Region: ABC_tran_2; pfam12848 882095009172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882095009173 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882095009174 beta-galactosidase; Region: BGL; TIGR03356 882095009175 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095009176 active site 882095009177 P-loop; other site 882095009178 phosphorylation site [posttranslational modification] 882095009179 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882095009180 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095009181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095009182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095009183 nucleotide binding site [chemical binding]; other site 882095009184 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095009185 methionine cluster; other site 882095009186 active site 882095009187 phosphorylation site [posttranslational modification] 882095009188 metal binding site [ion binding]; metal-binding site 882095009189 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095009190 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095009191 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095009192 putative active site [active] 882095009193 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 882095009194 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882095009195 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 882095009196 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882095009197 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882095009198 Walker A/P-loop; other site 882095009199 ATP binding site [chemical binding]; other site 882095009200 Q-loop/lid; other site 882095009201 ABC transporter signature motif; other site 882095009202 Walker B; other site 882095009203 D-loop; other site 882095009204 H-loop/switch region; other site 882095009205 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 882095009206 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 882095009207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882095009208 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882095009209 beta-galactosidase; Region: BGL; TIGR03356 882095009210 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882095009211 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882095009212 active site turn [active] 882095009213 phosphorylation site [posttranslational modification] 882095009214 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882095009215 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882095009216 HPr interaction site; other site 882095009217 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882095009218 active site 882095009219 phosphorylation site [posttranslational modification] 882095009220 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882095009221 CAT RNA binding domain; Region: CAT_RBD; smart01061 882095009222 PRD domain; Region: PRD; pfam00874 882095009223 PRD domain; Region: PRD; pfam00874 882095009224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882095009225 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882095009226 Walker A/P-loop; other site 882095009227 ATP binding site [chemical binding]; other site 882095009228 Q-loop/lid; other site 882095009229 ABC transporter signature motif; other site 882095009230 Walker B; other site 882095009231 D-loop; other site 882095009232 H-loop/switch region; other site 882095009233 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 882095009234 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 882095009235 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 882095009236 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 882095009237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009238 putative substrate translocation pore; other site 882095009239 GTP-binding protein YchF; Reviewed; Region: PRK09601 882095009240 YchF GTPase; Region: YchF; cd01900 882095009241 G1 box; other site 882095009242 GTP/Mg2+ binding site [chemical binding]; other site 882095009243 Switch I region; other site 882095009244 G2 box; other site 882095009245 Switch II region; other site 882095009246 G3 box; other site 882095009247 G4 box; other site 882095009248 G5 box; other site 882095009249 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 882095009250 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882095009251 methionine cluster; other site 882095009252 active site 882095009253 phosphorylation site [posttranslational modification] 882095009254 metal binding site [ion binding]; metal-binding site 882095009255 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882095009256 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882095009257 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882095009258 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882095009259 active site 882095009260 P-loop; other site 882095009261 phosphorylation site [posttranslational modification] 882095009262 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882095009263 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882095009264 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882095009265 HTH domain; Region: HTH_11; pfam08279 882095009266 Mga helix-turn-helix domain; Region: Mga; pfam05043 882095009267 PRD domain; Region: PRD; pfam00874 882095009268 PRD domain; Region: PRD; pfam00874 882095009269 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882095009270 active site 882095009271 P-loop; other site 882095009272 phosphorylation site [posttranslational modification] 882095009273 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095009274 active site 882095009275 phosphorylation site [posttranslational modification] 882095009276 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 882095009277 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 882095009278 tetramer interface [polypeptide binding]; other site 882095009279 heme binding pocket [chemical binding]; other site 882095009280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 882095009281 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 882095009282 ParB-like nuclease domain; Region: ParB; smart00470 882095009283 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 882095009284 salt bridge; other site 882095009285 non-specific DNA binding site [nucleotide binding]; other site 882095009286 sequence-specific DNA binding site [nucleotide binding]; other site 882095009287 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 882095009288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882095009289 P-loop; other site 882095009290 Magnesium ion binding site [ion binding]; other site 882095009291 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882095009292 Magnesium ion binding site [ion binding]; other site 882095009293 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882095009294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882095009295 non-specific DNA binding site [nucleotide binding]; other site 882095009296 salt bridge; other site 882095009297 sequence-specific DNA binding site [nucleotide binding]; other site 882095009298 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 882095009299 ParB-like nuclease domain; Region: ParBc; pfam02195 882095009300 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882095009301 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882095009302 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882095009303 putative active site [active] 882095009304 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882095009305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882095009306 nucleotide binding site [chemical binding]; other site 882095009307 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882095009308 active site 882095009309 phosphorylation site [posttranslational modification] 882095009310 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882095009311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095009312 motif II; other site 882095009313 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 882095009314 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 882095009315 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 882095009316 active site 882095009317 P-loop; other site 882095009318 phosphorylation site [posttranslational modification] 882095009319 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095009320 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095009321 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882095009322 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 882095009323 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 882095009324 putative active site cavity [active] 882095009325 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 882095009326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882095009327 S-adenosylmethionine binding site [chemical binding]; other site 882095009328 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882095009329 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882095009330 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882095009331 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882095009332 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 882095009333 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882095009334 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 882095009335 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 882095009336 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 882095009337 trmE is a tRNA modification GTPase; Region: trmE; cd04164 882095009338 G1 box; other site 882095009339 GTP/Mg2+ binding site [chemical binding]; other site 882095009340 Switch I region; other site 882095009341 G2 box; other site 882095009342 Switch II region; other site 882095009343 G3 box; other site 882095009344 G4 box; other site 882095009345 G5 box; other site 882095009346 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 882095009347 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882095009348 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 882095009349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882095009350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882095009351 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882095009352 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 882095009353 NADP binding site [chemical binding]; other site 882095009354 homodimer interface [polypeptide binding]; other site 882095009355 active site 882095009356 substrate binding site [chemical binding]; other site 882095009357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009358 D-galactonate transporter; Region: 2A0114; TIGR00893 882095009359 putative substrate translocation pore; other site 882095009360 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882095009361 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882095009362 metal binding site [ion binding]; metal-binding site 882095009363 dimer interface [polypeptide binding]; other site 882095009364 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882095009365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 882095009366 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882095009367 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882095009368 metal binding site [ion binding]; metal-binding site 882095009369 dimer interface [polypeptide binding]; other site 882095009370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095009371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882095009372 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 882095009373 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882095009374 Leucine-rich repeats; other site 882095009375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095009376 Substrate binding site [chemical binding]; other site 882095009377 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882095009378 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095009379 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095009380 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095009381 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095009382 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882095009383 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882095009384 Uncharacterized conserved protein [Function unknown]; Region: COG4198 882095009385 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 882095009386 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 882095009387 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882095009388 putative ligand binding site [chemical binding]; other site 882095009389 putative NAD binding site [chemical binding]; other site 882095009390 putative catalytic site [active] 882095009391 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 882095009392 L-serine binding site [chemical binding]; other site 882095009393 ACT domain interface; other site 882095009394 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 882095009395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882095009396 catalytic residue [active] 882095009397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095009399 putative substrate translocation pore; other site 882095009400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882095009401 MarR family; Region: MarR_2; pfam12802 882095009402 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 882095009403 dimer interface [polypeptide binding]; other site 882095009404 FMN binding site [chemical binding]; other site 882095009405 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882095009406 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882095009407 catalytic residues [active] 882095009408 beta-phosphoglucomutase; Region: bPGM; TIGR01990 882095009409 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882095009410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882095009411 motif II; other site 882095009412 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 882095009413 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 882095009414 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882095009415 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882095009416 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 882095009417 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882095009418 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882095009419 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882095009420 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882095009421 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882095009422 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 882095009423 putative NAD(P) binding site [chemical binding]; other site 882095009424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882095009425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095009426 dimer interface [polypeptide binding]; other site 882095009427 conserved gate region; other site 882095009428 putative PBP binding loops; other site 882095009429 ABC-ATPase subunit interface; other site 882095009430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882095009431 dimer interface [polypeptide binding]; other site 882095009432 conserved gate region; other site 882095009433 putative PBP binding loops; other site 882095009434 ABC-ATPase subunit interface; other site 882095009435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882095009436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882095009437 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882095009438 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882095009439 active site 882095009440 homodimer interface [polypeptide binding]; other site 882095009441 catalytic site [active] 882095009442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882095009443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882095009444 DNA binding site [nucleotide binding] 882095009445 domain linker motif; other site 882095009446 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 882095009447 putative dimerization interface [polypeptide binding]; other site 882095009448 putative ligand binding site [chemical binding]; other site 882095009449 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 882095009450 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882095009451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882095009452 Coenzyme A binding pocket [chemical binding]; other site 882095009453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095009455 putative substrate translocation pore; other site 882095009456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009457 Domain of unknown function (DUF718); Region: DUF718; cl01281 882095009458 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 882095009459 intersubunit interface [polypeptide binding]; other site 882095009460 active site 882095009461 Zn2+ binding site [ion binding]; other site 882095009462 L-rhamnose isomerase; Provisional; Region: PRK01076 882095009463 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 882095009464 N- and C-terminal domain interface [polypeptide binding]; other site 882095009465 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 882095009466 active site 882095009467 putative catalytic site [active] 882095009468 metal binding site [ion binding]; metal-binding site 882095009469 ATP binding site [chemical binding]; other site 882095009470 carbohydrate binding site [chemical binding]; other site 882095009471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882095009472 putative substrate translocation pore; other site 882095009473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882095009474 Cupin domain; Region: Cupin_2; pfam07883 882095009475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882095009476 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 882095009477 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 882095009478 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 882095009479 G-X-X-G motif; other site 882095009480 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 882095009481 RxxxH motif; other site 882095009482 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 882095009483 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 882095009484 ribonuclease P; Reviewed; Region: rnpA; PRK00499 882095009485 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399